中国当代医药
      Home                              中文
中国当代医药
 
Forthcoming Articles
Current Issue
Archive
Advanced Search
Read Articles
Download Articles
Email Alert
 
Quick Search  
  Adv Search
2021 Vol. 28, No. 22
Published: 2021-08-08
 
 
4 Effect of Shugan Jieyu Capsules combined with Aripiprazole in the treatment of schizophrenia patients with depressive symptoms and its influence on serum total superoxide dismutase
GAO Yun; LYU Shuang; CUI Wen-yan; LUO Chun-xia; LU Wei-yu ;ZHONG Yu-long
Objective To explore the effect of Shugan Jieyu Capsules combined with Aripiprazole in the treatment of schizophrenia with depressive symptoms and its influence on serum total superoxide dismutase(T-SOD).Methods A total of 80 schizophrenic patients with depressive symptoms admitted to the Guangzhou Civil Affairs Bureau Mental Hospital from February to December 2020 were selected as the research subjects.According to random number table method,they were divided into study group(40 cases)and control group(40 cases).The control group was treated with Aripiprazole,and the research group was treated with Shugan Jieyu Capsules combined with Aripiprazole.Clinical efficacy,Hamilton depression scale(HAMD)score and T-SOD level were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in HAMD scores between the two groups before treatment(P>0.05).After treatment,the HAMD score of the two groups were lower than those before treatment,and the HAMD score of the study group was lower than that of the control group,the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in serum T-SOD level between the two groups(P>0.05).The level of T-SOD in the study group was higher than that in the control group after treatment,and the difference was statistically significant(P<0.05).The level of T-SOD in the study group after treatment was higher than that before treatment,the difference was statistically significant(P<0.05),while there was no statistically significant difference in the level of T-SOD in the control group before and after treatment(P>0.05).Conclusion Shugan Jieyu Capsules are effective in the treatment of schizophrenia accompanied by depressive symptoms,which can improve the depressive symptoms of patients,and help to improve the level of T-SOD.
2021 Vol. 28 (22): 4-7 [Abstract] ( 41 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
8 Screening and identification of biomarkers for breast cancer brain metastasis based on bioinformatics
SHAO Ming-tao； WANG Xing ；LI Wei-wen
Objective To find the key biomarkers related to the prognosis of breast cancer brain metastasis.Methods The microarray data set GSE125989 was retrieved from the GEO database,and the GEO2R tool was used to screen the relevant differentially expressed genes.The STRING database was used to analyze the protein-protein interactions of the differential genes,and the Cytoscape software was used for visualization and screening of key biomarkers.The Kaplan-Meier survival analysis database was used to determine the prognostic potential of the key biomarkers screened.Results In this study,311 differentially up-regulated genes and 104 differentially down-regulated genes were screened,and 10 key genes were screened,including fibronectin 1(FN1),vascular endothelial growth factor A(VEGFA),type Ⅰcollagen α1 chain(COL1A1),matrix metalloproteinase 2(MMP2),type Ⅲcollagen α1 chain(COL3A1),type Ⅰcollagen α2 chain(COL1A2),periosteal protein(POSTN),decorin(DCN),biglycan(BGN)and lysyl oxidase(LOX).Kaplan-Meier survival analysis showed that high expressions of FN1 and VEGFA were associated with poor overall survival(OS)(FN1: HR=1.28,95%CI=1.03-1.59, P=0.023 00; VEGFA: HR=1.35,95%CI =1.09-1.68, P=0.005 50),and low expression of DCN was associated with poor OS(HR=0.69,95%CI=0.56-0.86, P=0.000 71).High expressions of FN1,VEGFA,COL1A1,POSTN,BGN,and LOX were associated with poor distant metastasis-free survival(DMFS)(FN1: HR=1.22,95%CI=1.01-1.48, P=0.041 00; VEGFA: HR=1.39,95%CI=1.14-1.68, P=0.000 95; COL1A1: HR=1.53,95%CI=1.09-2.14, P=0.012 00; POSTN: HR=1.61,95%CI=1.16-2.24, P=0.004 20; BGN: HR=1.29,95%CI=1.07-1.57, P=0.009 20; LOX: HR=1.28,95%CI=1.06-1.55, P=0.012 00),and low expression of DCN was associated with poor DMFS(HR=0.82,95%CI=0.67-0.99, P=0.042 00).Conclusion FN1,VEGFA and DCN can be used as key biomarkers related to the prognosis of breast cancer brain metastasis.
2021 Vol. 28 (22): 8-11转15 [Abstract] ( 41 ) HTML (40 KB)  PDF  (0 KB)  ( 6 )
11 Effect of Netrin-1 on migration and apoptosis of hepatocellular carcinoma cells under hypoxia
LIN Hai-hua； YU Yu-hong； LYU Jia-min； ZHANG Shao-min； ZHANG Yuan-zhi
Objective To study the expression changes of axon guidance factor Netrin-1 and its effect on the migration and apoptosis of hepatocellular carcinoma cells HepG2 under hypoxia.Methods HepG2 cells were cultured in 1% O2 anoxic environment.The expression of Netrin-1 in HepG2 cells under hypoxia was detected by Western-blot.Interfering plasmid shRNA-Netrin-1 mRNA was constructed and stably transfected into HepG2 cells.Transwell method and flow cytometry were used to observe the changes of cell migration and invasion and apoptosis rate of HepG2 cells under normal and hypoxia conditions.Results The expression level of Netrin-1 protein in HepG2 cells was increased after 24 h hypoxia culture,cell migration experiments indicated hypoxia promoted the migration of HepG2 cells,flow cytometry results showed that the apoptosis of HepG2 cells was inhibited by hypoxia,the differences were statistically significant(P<0.05).The Netrin-1 knockdown significantly inhibited the hypoxia induced HepG2 cell migration,the number of permeable cells in shRNA-Netrin-1-HepG2 cells decreased,and the Netrin-1 knockdown could also increase HepG2 cell apoptosis ratio,the differences were statistically significant(P<0.05).Conclusion Hypoxia can promote hepatocellular carcinoma cell Netrin-1 expression,and hypoxia promotes the migration of hepatocellular carcinoma cells HepG2 and inhibits their apoptosis,which may be related to the increased expression of Netrin-1.
2021 Vol. 28 (22): 11-15 [Abstract] ( 52 ) HTML (39 KB)  PDF  (0 KB)  ( 8 )
16 Effect comparison of different courses of glucocorticoid in the treatment of moderate and severe subacute thyroiditis
ZHONG Li-li
Objective To investigate the effect of different courses of glucocorticoid in the treatment of moderate and severe subacute thyroiditis.Methods Sixty patients with moderate and severe subacute thyroiditis admitted to Xinyu People′s Hospital from October 2018 to October 2019 were selected as the research subjects.They were divided into control group(30 cases)and observation group(30 cases)by random number table method.The control group received glucocorticoid treatment for 8 weeks.The observation group received glucocorticoid therapy for 6 weeks.Clinical efficacy,adverse reactions(weight gain,facial acne and digestive tract discomfort),treatment compliance and recurrence were compared between the two groups.Results There was no significant difference in the total effective rate between the two groups(P>0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total treatment compliance of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in recurrence rate between the two groups(P>0.05).Conclusion Patients with moderate and severe subacute thyroiditis treated with glucocorticoid for 8 weeks and 6 weeks can achieve ideal results,but the treatment for 6 weeks can improve the compliance of patients,and help to reduce the incidence of adverse reactions,which has a certain feasibility.
2021 Vol. 28 (22): 16-19 [Abstract] ( 43 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
20 Study on evaluation of diagnostic efficacy of Elecsys HIV Duo assay
HUANG Ji-de； TAN Ming-kai ；HUANG Ying； XIAO Yun-ju； SHI Ya-ling
Objective To evaluate the detection performance of human immunodeficiency virus(HIV)detection reagent Elecsys HIV Duo,and to explore the clinical application value of HIV Duo.Methods The performance of the test method was evaluated according to the performance verification guidelines of clinical chemistry quantitative test procedure.A total of 105 serum samples of HIV positive patients were collected from the Eighth Affiliated Hospital of Guangzhou Medical University in December 2020 to verify the detection ability of Elecsys HIV Duo in different stages of HIV infection.Results The intra assay precision of three concentration samples were 4.03%,0.95% and 0.81%,respectively,which were lower than 6.25%(1/4 TEa).The interbatch precision were 4.7%,1.23%,1.66%,respectively,less than 8.33%(1/3 TEa).A total of 57 samples containing potential interfering substances were detected by Elecsys HIV Duo assay,and the results showed that the specificity of the assay was 100%.The coincidence rate of p24 antigen and HIV antibody negative and positive results were both 100%.The detection limit of p24 antigen was 0.62 U/mL,while HIV-1 antibody was still detectable at the level of 1 NCU/mL.Anti-interference ability: the samples containing 20 mg/L bilirubin,800 mg/L hemoglobin,and 2000 mg/L intralipid were detected by Elecsys HIV Duo assay.The coincidence rate between measured values before and after adding interference substances was ≥80%.The detection results of 105 positive samples in different infection periods showed that the system can detect effectively.Conclusion HIV-1 p24 antigen and antibodies were detected by the Elecsys HIV Duo assay separately,and the assay has a good diagnostic value in HIV antigen and antibody detection,which has a great help in the diagnosis of early HIV-infected cases.
2021 Vol. 28 (22): 20-23 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
24 Effect and safety of titrated Recombinant Human Brain Natriuretic Peptide in the treatment of refractory acute decompensated heart failure
JING Feng
Objective To explore the efficacy and safety of Recombinant Human Brain Natriuretic Peptide(rhBNP)titration in the treatment of refractory acute decompensated heart failure(ADHF).Methods A total of 300 patients with refractory ADHF admitted to the Ansteel Group General Hospital from June 2018 to June 2020 were selected as the research objects.They were divided into the group A(150 cases)and the group B(150 cases)according to the random odd and even number method.The group A was given rhBNP fixed dose administration scheme,and the group B was given rhBNP titration dose administration scheme.The 24 hours urine volume,systolic blood pressure(SBP),mean arterial pressure(MAP),N-terminal pro brain natriuretic peptide(NT-proBNP),aldosterone(ALD),creatinine clearance rate(CC),left ventricular ejection fraction(LVEF),pulmonary artery pressure(PAP),hospitalization time,thirty days readmission rate and adverse reactions were compared between the two groups.Results Before the treatment,there were no significant differences in 24 hours urine volume,SBP,MAP,NT-proBNP,ALD,CC,LVEF and PAP between the two groups(P>0.05).After the treatment,24 hours urine volume of the group B was higher than that of the group A,SBP,MAP,NT-proBNP,ALD,PAP values of the group B were lower than those of the group A,the differences were statistically significant(P<0.05).There were no significant differences in CC and LVEF between the two groups(P>0.05).The hospitalization time of the group B was shorter than that of the group A,thirty days readmission rate of the group B was lower than that of the group A,and the differences were statistically significant(P<0.05).There was no significant difference in total incidence of adverse reactions between the two groups(P>0.05).Conclusion Giving rhBNP titration to treat the patients with refractory ADHF,the effect of symptom relief is better,and the safety of clinical treatment is also considered.
2021 Vol. 28 (22): 24-27 [Abstract] ( 41 ) HTML (38 KB)  PDF  (0 KB)  ( 5 )
28 Performance verification and evaluation of fluorescent quantitative detection method for HBV DNA
CHEN Mei-lian； XIE Li-zhu； MO Qi-wen； LI Liu-yan； XIE Ling-ping； FANG Xiu-zhu
Objective To verify performance and evaluation of fluorescent quantitative detection method for hepatitis B virus deoxyribonucleic acid(HBV DNA).Methods According to the requirements of Application of accreditation criteria for quality and competence of medical laboratories in molecular diagnosis(CNAS-CL36)and EP series documents by the Clinical and Laboratory Standards Institute(CLSI),the precision,measurement accuracy,anti-interference ability,linear range and limit of detection of HBV DNA fluorescence quantitative PCR detection system were verified and evaluated.Results The intra assay CV of low(1×103 U/mL)and high(1×106 U/mL)value specimens were 0.07% and 0.06%,respectively,while the inter assay CV were 0.11% and 0.08%,respectively.Its accuracy was within acceptable range.The samples containing triglyceride,bilirubin,hemoglobin were detected,and the deviation between the measured value and the expected value was ≤±lg0.4.It exhibited a benign linear relation from 1.45×102-1.45×109 U/mL(Y=1.042X-0.337，R2=0.997),and the limit of detection was 100 U/mL.Conclusion The performance indexes of the fluorescent quantitative detection method of HBV DNA are consistent with the manufacturer′s statement,which can be used for routine clinical detection.
2021 Vol. 28 (22): 28-31 [Abstract] ( 35 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
32 Research progress on pharmacological effect of salvianolate
LIU Hui-hui；YIN Jia；QIANG Ming-min；LIU Mei-lin；GAO Yu-qin
Salvianolate is an extract of Salvia miltiorrhiza.Its main component is salvianolic acid B magnesium.On the cardiovascular system,respiratory system,digestive system,urinary system,endocrine system has the adjustment function.It has the functions of regulating menstruation and promoting blood circulation,dispersing knot and relieving pain,anti-oxidative stress,anti-inflammatory,anti-platelet aggregation,anti-thrombosis,dilating blood vessels and improving heart function.Clinically,it can be used to treat diseases such as coronary heart disease,chronic obstructive pulmonary disease,pulmonary hypertension,colitis and renal failure.Therefore,this paper reviews the pharmacological effect and adverse reactions of salvianolate in recent years,which provides a basis for the clinical medication and the further development of salvianolate.
2021 Vol. 28 (22): 32-36转41 [Abstract] ( 52 ) HTML (54 KB)  PDF  (0 KB)  ( 8 )
37 Research progress of cholesterol and its metabolites in breast cancer
ZHAO Yi-ting; DONG Wen-wen; CUI Meng-sheng
Studies have found that cholesterol has an important relationship with breast cancer,but the molecular mechanism is not yet clear.27-hydroxycholesterol(27-HC)is a key regulator of cholesterol and breast cancer pathogenesis.27-HC can not only promote the growth of estrogen receptor-positive breast cancer cells,but also stimulate cell proliferation and metastasis in several breast cancer models.These will provide a theoretical basis for studying the effect of drugs that inhibit cholesterol or 27-HC synthesis on the prognosis of breast cancer.Further study on the relationship between specific molecular subtypes of breast cancer and a certain blood lipid index can provide new targets for precise treatment and prognosis of breast cancer patients.This article summarizes the relationship between the occurrence and development of breast cancer and cholesterol and its metabolites.
2021 Vol. 28 (22): 37-41 [Abstract] ( 47 ) HTML (44 KB)  PDF  (0 KB)  ( 6 )
42 Determination and analysis of insoluble particles and pH after compatibility of Aminomethylbenzoic Acid and Etamsylate
YANG Jin-yuan
Objective To investigate the changes of insoluble particles and pH value of the mixed Aminomethylbenzoic Acid Injection in different proportions and Etamsylate Injection in different infusions,and explore the rationality of the prescriptions often used in Jiangmen People′s Hospital and provide reference basis for clinical rational use.Methods The intravenous infusion prescriptions for the combined use of Aminomethylbenzoic Acid Injection and Etamsylate Injection prescribed in Jiangmen People′s Hospital from 2017 to 2019 were extracted from the hospital information system.These commonly used prescriptions in mixed ratios were counted,and the changes in particles,pH,color,and clarity within 6 hours were observed,and their safety and rationality were analyzed.Results 0.3 g of Aminomethylbenzoic Acid Injection,0.5 g of Etamsylate Injection,250 mL of 0.9% sodium chloride injection or 250 mL of 5% glucose injection,as well as 0.4 g of Aminomethylbenzoic Acid Injection and 2 g of Etamsylate Injection and 250 mL 0.9%sodium chloride injection were three commonly used ratios in combations.Within 0-6 hours,their particles,pH values and appearance were basically stable.Conclusion The mixed infusion of the three commonly used ratios of Aminomethylbenzoic Acid and Etamsylateis is stable within 6 hours and can be used safely in clinical practice.
2021 Vol. 28 (22): 42-44转51 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
45 Analysis of the reasons for failure in screening healthy subjects for bioequivalence test in Phase ⅠLaboratory of Yueyang Second People′s Hospital
LI Yan
Objective To analyze the reasons of failure in screening healthy subjects for bioequivalence test in PhaseⅠLaboratory of Yueyang Second People′s Hospital.Methods The screening data of healthy subjects in bioequivalence test conducted in Yueyang Second People′s Hospital from June 2020 to October 2020 were retrospectively analyzed.The reasons for the failure of screening were discussed from the aspects of subject recruitment,vital signs,compliance and laboratory examination items.Results A total of 4 studies were collected in this study,111 healthy subjects were screened,72 successful subjects(64.86%)were screened.There were no significant differences in the proportion of male and female,age between successful and failure subjects(P>0.05).The main causes of failure were laboratory examination results,compliance and vital signs.Conclusion Laboratory examination,compliance and vital signs are the important reasons for the failure of screening healthy subjects.It is suggested that the success rate of screening healthy subjects should be improved by establishing appropriate range of laboratory indicators and strengthening informed consent.
2021 Vol. 28 (22): 45-47 [Abstract] ( 38 ) HTML (29 KB)  PDF  (0 KB)  ( 6 )
48 Application value of atrial electrocardiogram in the location of implantable venous access port in the patients with mammary cancer
FU Qin; DING Zhi-juan; YIN Fei-fei; ZHANG Rui-ying; SHAO Juan
Objective To explore the application value of atrial electrocardiogram in the location of implantable venous access port in the patients with mammary cancer.Methods From May 2019 to May 2020,a total of 88 patients with mammary cancer who were to treated with totally implantable venous access ports(TIVAP)chemotherapy admitted to Jiangxi Cancer Hospital were selected as the research objects,and divided into the experimental group and the control group according to the random number table method,with 44 cases in each group.In the control group,TIVAP was located and catheterized with conventional methods,while in the experimental group,TIVAP was located and catheterized with the assistance of atrial electrocardiogram.The success rate of one-time catheterization was compared between the two groups,the position of catheter tip was determined by chest X-ray film as control,the accuracy of catheter tip positioning was compared between the two groups,and the complications related to catheterization and satisfaction of patients with catheterization were counted.Results The success rate of one-time catheterization and the accuracy of catheter tip positioning in the experimental group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of complications in the experimental group was lower than that in the control group,with statistically difference(P<0.05).The total satisfaction of the experimental group was higher than that of the control group,with statistically difference(P<0.05).Conclusion Catheter placement in the infusion port of mammary cancer patients under the guidance of atrial electrocardiogram can improve the accuracy of catheter tip location,reduce related complications,and improve the success rate of catheter placement and patient satisfaction.
2021 Vol. 28 (22): 48-51 [Abstract] ( 38 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
52 Related factors of chronic renal failure combined with upper gastrointestinal hemorrhage and its relationship with gastrin-17,pepsinogen I and pepsinogen Ⅱ
LI Yong-qiang； ZOU Yang；WANG Ling；WANG Jia-fang
Objective To explore the related factors of chronic renal failure(CRF)combined with upper gastrointestinal hemorrhage(UGH)and its relationship with gastrin-17(G-17),pepsinogen Ⅰ(PG-Ⅰ)and pepsinogen Ⅱ(PG-Ⅱ).Methods The clinical data of 80 CRF patients admitted to Kangning Hospital of Jiangxi from June 2019 to December 2020 were retrospectively analyzed.According to presence or absence of UGH symptoms,they were divided into UGH group(33 cases)and non-UGH group(47 cases).The clinical data(including the gender,age,G-17,PG-Ⅰ/PG-Ⅱ,usage of unfractionated heparin or not,and stress ulcer or not)were compared between the two groups,and the related factors of UGH were analyzed.Results The results of univariate analysis showed that the differences in the age,G-17,PG-Ⅰ,PG-Ⅱ,PG-Ⅰ/PG-Ⅱ,usage of unfractionated heparin,and stress ulcer between the two groups were statistically significant(P<0.05).The results of multivariate analysis showed that G-17,PG-Ⅰ/PG-Ⅱand stress ulcer were correlative factors of CRF combined with UGH(P<0.05). Spearman correlation analysis showed that G-17,PG-Ⅰand PG-Ⅱwere positively correlated with CRF combined with UGH(r=0.614,0.582,0.591, P<0.05).Conclusion G-17,PG-Ⅰ/PG-Ⅱand stress ulcer are risk factors of CRF combined with UGH,and G-17,PG-Ⅰand PG-Ⅱare significantly related to CRF combined with UGH.
2021 Vol. 28 (22): 52-54转58 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
55 Clinical effect of Bortezomib combined with Dexamethasone in the treatment of elderly multiple myeloma and the influence on the levels of thrombopoietin and immune cells
RUI Ming-zhong；WANG Zi-yan；LU Xi
Objective To explore the clinical effect of Bortezomib combined with Dexamethasone in the treatment of elderly multiple myeloma and the influence on the levels of thrombopoietin and immune cells.Methods A total of 40 elderly patients with multiple myeloma admitted to Shangrao Municipal Hospital of Jiangxi Province from January 2015 to October 2020 were selected as the research objects and divided into the control group(20 cases)and the observation group(20 cases)according to the random drawing lots method.The control group was treated with Vincristine,Dexamethasone combined with Epirubicin,and the observation group was treated with Bortezomib combined with Dexamethasone.The therapeutic effects the levels of immunosuppressive factors(interleukin-6[IL-6]and interleukin-17[IL-17]),immune cells(CD3+CD4+,CD3+CD8+,CD3+CD4+/CD3+CD8+),thrombopoietin(TPO)and transforming growth factor-β(TGF-β)before and after treatment were compared between the two groups.Results After treatment,the total effective rate of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The IL-6 and IL-17 of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The CD3+CD4+,CD3+CD4+/CD3+CD8+ of the observation group were higher than those of the control group,the CD3+CD8+ of the observation group was lower than that of the control group,the differences were statistically significant(P<0.05).The TPO and TGF-β in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion The clinical effect of Bortezomib combined with Dexamethasone in the treatment of elderly multiple myeloma is significant,which can not only improve the level of immunosuppressive factors,but also improve the level of immune cells,which is suitable for clinical implementation and development.
2021 Vol. 28 (22): 55-58 [Abstract] ( 42 ) HTML (41 KB)  PDF  (0 KB)  ( 6 )
59 Effect of Lactobacillus combined with Doxycycline in the treatment of female genital tract chlamydia infection
LIU Su-mei； KANG Lian-feng； JIANG Mei-jiao
Objective To explore the effect of Lactobacillus combined with Doxycycline in the treatment of female genital chlamydia infection.Methods A total of 60 female genital chlamydia infections admitted to Ganzhou Maternal and Child Health Hospital from May 2020 to January 2021 were retrospectively selected.According to the different treatment methods,the patients were divided into two groups,30 cases in each group.Patients in the control group were treated with Doxycycline,and in the observation group,they were treated with Lactobacillus combined with Doxycycline.The clinical treatment effect,total incidence of adverse reactions,and clinical symptoms improvement time were compared between the two groups.Results The total treatment effectiveness rate of the observation group was higher than that of the control group,with statistical significance(P<0.05).The total incidence of adverse reactions in the observation group was lower than that of the control group,with statistical significance(P<0.05).The clinical symptoms improvement time of the observation group was shorter than that of the control group,with statistical significance(P<0.05).Conclusion Combined use of Lactobacillus and Doxycycline in the treatment of female genital tract chlamydia infection can effectively improve the treatment effect,reduce the incidence of adverse reactions,and shorten the time for clinical symptom improvement with a remarkable effect.
2021 Vol. 28 (22): 59-61转65 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
62 Effect and safety analysis of antituberculosis combined with electronic bronchoscopy in the treatment of patients with bronchial tuberculosis
CHEN Ting-xian； HUANG Zu-jun； FENG Xiao-hong
Objective To investigate the effect and safety of antituberculosis combined with electronic bronchoscopy in the treatment of patients with bronchial tuberculosis.Methods A total of 82 patients with bronchial tuberculosis admitted to Yangjiang Public Health Hospital from March 2018 to December 2019 were selected as the research objects and divided into the reference group(41 cases)and the experimental group(41 cases)according to the random assignment method.The reference group was treated with conventional antituberculosis treatment,and the experimental group was treated with antituberculosis combined with electronic bronchoscopy.The total effective rate,airway cavity diameter after 1 and 6 months of treatment,sputum negative conversion rate,recurrence rate and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that of the reference group,and the difference was statistically significant(P<0.05); the airway cavity diameter of the experimental group was larger than that of the reference group after 1,6 months of treatment,and the difference was statistically significant(P<0.05).After 2 months of treatment,the sputum negative conversion rate in the experimental group was higher than that of the reference group,the recurrence rate of the experimental group was lower than that of the reference group,the differences were statistically significant(P<0.05).After the treatment,there was no statistically difference in total incidence of adverse reactions between the two groups(P>0.05).Conclusion Antituberculosis combined with electronic bronchoscopy could obtain higher curative effect,low recurrence rate,good long-term curative effect in the treatment of patients with bronchial tuberculosis,and would not cause excessive adverse reactions,with high safety,which is worthy of recommendation.
2021 Vol. 28 (22): 62-65 [Abstract] ( 41 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
66 Discussion and analysis of the treatment of acute ST-segment elevation myocardial infarction in the construction of chest pain center in a seccond class hospital
ZHANG Ding-hua
Objective To investigate the application effect of chest pain center construction in the treatment of acute ST-segment elevation myocardial infarction(STEMI).Methods The clinical data of 90 STEMI patients who underwent emergency percutaneous coronary intervention(PPCI)in Xinyu Fourth Hospital from January to August 2019(before the certification of chest pain center)were retrospectively analyzed and included in group A.Clinical data of 80 STEMI patients admitted from September 2019 to May 2020(in the certification of chest pain center)were included in group B.Clinical data of 132 STEMI patients from June to December 2020(after chest pain center certification)were included in group C.The door to balloon(D2B)time,the symptom onset to balloon(S2B)time,the incidence of in-hospital heart failure,the mortality rate,the length of hospital stay and the cost of the three groups were compared.Results D2B time in group B and C were shorter than that in group A,and D2B time in group C was shorter than that in group B,the differences were statistically significant(P<0.05).There was no significant difference in S2B time among the three groups(P>0.05).Group C and B had shorter hospitalization time and less hospitalization cost than group A,the differences were statistically significant(P<0.05).There was no significant difference in the length and cost of hospitalization between group C and group B(P>0.05).There was no significant difference in the incidence and mortality of nosocomial heart failure among the three groups(P＞0.05).Conclusion The establishment of chest pain center can significantly shorten D2B of STEMI patients and reduce hospitalization costs,which is worthy of promotion
2021 Vol. 28 (22): 66-68 [Abstract] ( 39 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
69 Analysis of related risk factors of non-reflow after emergency coronary intervention for ST-segment elevation myocardial infarction
LIU Jun-qiang
Objective To investigate the risk factors of non-reflow after ST-segment elevation myocardial infarction(STEMI)by percutaneous coronary intervention(PCI).Methods A total of 100 STEMI patients who underwent PCI treatment in Foshan Nanhai District People′s Hospital from January 2018 to April 2020 were selected as the research subjects.According to the blood flow of thrombolysis in myocardial infarction(TIMI)in patients with acute myocardial infarction,they were divided into non-reflow group(27 cases)and reflow group(73 cases).Relevant data were collected and the related risk factors of non-reflow after STEMI by PCI.Results The proportion of smoking history,calciumdependent C-type lectin-like receptor 2(CLEC-2)and low-density lipoprotein cholesterol(LDL-C)levels in the nonreflow group were 33.33%,(239.15±56.45)pg/mL,(3.53±1.21)mmol/L,respectively,higher than those in the reflow group of 12.33%,(185.07±33.96)pg/mL,and(2.32±0.87)mmol/L,and the differences were statistically significance(P<0.05).Diastolic blood pressure,systolic blood pressure,and high-density lipoprotein cholesterol(HDL-C)levels in the flow group were(65.78±16.21)mmHg,(101.67±24.96)mmHg,and(1.44±0.59)mol/L,respectively,lower than those in the reflow group of(72.82±13.48)mmHg,(115.21±23.67)mmHg,(2.01±0.48)mol/L,and the differences were statistically significance(P<0.05).Multivariate Logistic regression analysis showed that smoking history(β=1.269,OR=3.556,95%CI=1.230-10.280),CLEC-2 ≥214.58 pg/mL(β=1.749, OR=5.750,95%CI=1.254-26.358),LDL-C≥3.37 mmol/L(β=2.015, OR=7.500,95%CI=1.645-34.197),systolic blood pressure <120 mmHg(β=1.255, OR=3.509,95%CI=0.750-16.422)were independent risk factors of non-reflow after STEMI by PCI(P<0.05).Conclusion Non-reflow after STEMI by PCI is closely related to smoking history,CLEC-2,LDL-C,and systolic blood pressure,and clinical prevention and control needs to be strengthened.
2021 Vol. 28 (22): 69-71转75 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 5 )
72 Clinical effect of compound technology in the treatment of aortic dissection
CAI Long-ren； WU Cheng； LI Yan； PENG Xing-hua； ZHONG Feng-wen
Objective To investigate the clinical effect of compound technology in the treatment of aortic dissection.Methods Thirty patients with aortic dissection admitted to Ganzhou People′s Hospital from January 2015 to March 2020 were selected as the research objects.They were divided into a control group and a study group according to the lottery method,with 15 cases in each group.The control group was given chimney technique + aortic stent graft treatment,and the study group was given compound technique treatment.The surgical indicators,liver and kidney function indicators before and after surgery,postoperative complications,deaths during follow-up and occurrence of complications were compared between the two groups.Results The operation time of the study group was longer than that of the reference group,the hospital stay was shorter than that of the reference group,and the medical expense was lower than that of the reference group,the differences were statistically significant(P<0.05); the comparison of intraoperative blood loss between the two groups was not statistically significant(P＞0.05).Before and after operation,there were no significant differences in liver and renal function indexes between two groups(P>0.05).The levels of glutamic oxalacetic transaminase,glutamic pyruvic transaminase,serum creatinine and serum urea in the study group were higher than those before operation,the levels of glutamic oxalacetic transaminase,glutamic pyruvic transaminase and serum urea in control group were higher than before operation,the differences were statistically significant(P＜0.05).There was no significant difference in the total incidence of postoperative complications between the two groups(P>0.05).During the follow-up period,there was no death in the two groups,and there was no statistically significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion Compound technique in the treatment of aortic dissection can shorten the length of hospital stay,reduce medical costs,and do not cause obvious damage to liver and kidney function,the prognosis is good,worthy of extensive use.
2021 Vol. 28 (22): 72-75 [Abstract] ( 46 ) HTML (37 KB)  PDF  (0 KB)  ( 8 )
76 Clinical effect of Benazepril combined with L-carnitine in the treatment of patients with heart failure
TAN Tian-xing
Objective To investigate the clinical effect of Benazepril combined with L-carnitine in the treatment of patients with heart failure.Methods A total of 68 patients with heart failure who were addmited in the Second People′s Hospital of Baiyun District from August 2019 to August 2020 were selected as subjects.They were divided into the control group and the study group by random number table,with 34 cases in each group.The control group was treated with Benazepril,and the study group was treated with L-carnitine+Benazepril.Cardiac function indexes(left ventricular end-diastolic volume[LVEDV],left ventricular ejection fraction[LVEF]and cardiac output[CO]),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),plasma N-terminal brain natriuretic peptide precursor(NT-proBNP)levels and walking distance within 6 minutes before and after treatment were compared between the two groups.Results After treatment,the LVEDV level of the study group was lower than that of the control group,and the levels of LVEF and CO were higher than those of the control group,and the differences were statistically significant(P<0.05).In the study group,the walking distance within 6 min after 8 and 16 days of treatment was longer than that in the control group,and the difference was statistically significant(P<0.05).The levels of NT-proBNP,IL-6,and TNF-α in the study group were lower than those in the control group after treatment,and the differences were statistically significant(P<0.05).Conclusion The application of L-carnitine+Benazepril for heart failure has a better effect,which can improve the patient′s heart function,increase exercise endurance,reduce the inflammatory response in the body,and improve the treatment effect.
2021 Vol. 28 (22): 76-78转82 [Abstract] ( 42 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
79 Application effect of Ticagrelor on antiplatelet therapy after percutaneous coronary intervention in acute myocardial infarction
WANG Yan-ling
Objective To investigate the application effect of Ticagrelor in antiplatelet therapy after percutaneous coronary intervention(PCI)for acute myocardial infarction.Methods A total of 100 patients with acute myocardial infarction admitted to Xiangzhou District People′s Hospital of Xiangyang city from January 2019 to June 2020 were selected as the research objects,and were divided into observation group and control group according to random number table method,with 50 patients in each group.The observation group received Aspirin+Ticagrelor before and after PCI,and the control group received Aspirin+Clopidogrel before and after PCI.The platelet aggregation rate,liver function,the incidence of adverse reactions and the total incidence of adverse cardiovascular events in two groups were compared.Results There was no significant difference in platelet aggregation rate between the two groups before operation(P>0.05).The platelet aggregation rate of observation group at 2,24 h and 7 d after surgery were lower than those of control group,the differences were statistically significant(P<0.05).There was no significant difference in liver function between the two groups before surgery(P>0.05).The levels of glutamic-oxalacetic transaminase and serum creatinine in the observation group at 7 d after operation were higher than those before operation and those in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse cardiovascular events in observation group was lower than that in control group,the difference was statistically significant(P<0.05).Conclusion Ticagrelor has a significant effect on antiplatelet therapy after PCI in acute myocardial infarction with high safety and is worthy of clinical promotion.In summary,ticagrelor is effective in antiplatelet therapy after PCI for acute myocardial infarction,and it is worthy of clinical application.
2021 Vol. 28 (22): 79-82 [Abstract] ( 36 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
83 Effect comparison of the stereotactic cone puncture and soft channel drainage of intracranial hematoma surgery and bone flap decompression and removal of intracranial hematoma suegery in the treatment of cerebral hemorrhage
LUO Yun-hui
Objective To compare the effect of stereotactic cone puncture and soft channel drainage of intracranial hematoma surgery and bone flap decompression and removal of intracranial hematoma surgery in the treatment of cerebral hemorrhage(ICH).Methods A total of 82 patients with ICH in Nanchang 334 Hospital from September 2017 to August 2020 were selected as subjects and divided into the study group and the control group according to random number table method,with 41 cases in each group.The control group was given bone flap decompression and removal of intracranial hematoma surgery,and the study group was given stereotactic cone puncture and soft channel drainage of intracranial hematoma surgery.The rebleeding situation and Glasgow outcome scale score(GOS)grading of the two groups of patients 72 hours after surgery,National Institutes of Health stroke scale(NIHSS)score and residual hematoma volume before and 72 h after surgery were compared.Results The total excellent and good rate of 72 h GOS grading in the study group was higher than that of the control group,and the rebleeding rate at 72 h after the surgery was lower than that of the control group,and the differences were statistically significant(P<0.05).The volume of residual hematoma in the study group was smaller than that in the control group at 72 hours after surgery,and the difference was statistically significant(P<0.05).The NIHSS score of the study group was lower than that of the control group at 72 h after surgery,and the difference was statistically significant(P<0.05).Conclusion Stereotactic cone puncture and soft channel drainage of intracranial hematoma surgery can significantly improve the nerve function and rebleeding of ICH patients,eliminate residual hematoma,and help patients recover.
2021 Vol. 28 (22): 83-85 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
86 Application effect of hospital discharge preparation plan in patients with hypertensive basal ganglia cerebral hemorrhage
YAO Nan-nan； ZHANG Jin-ling； LIU Qun； CHEN Guang-yuan
Objective To explore the application effect of hospital discharge preparation plan in patients with hypertensive basal ganglia intracerebral hemorrhage.Methods The clinical data of 60 patients with hypertensive basal ganglia cerebral hemorrhage admitted to Luoyang Central Hospital from January 2020 to August 2020 were retrospectively analyzed.According to different intervention methods,they were divided into the control group(30 cases)and the observation group(30 cases).The control group used routine intervention,and the observation group used the hospital discharge preparation plan.Before discharge,the readiness for hospital disccharge scale(RHDS)and compliance behavior of the two groups were recorded,and the activities of daily living(BI index)and limb motor function score(FMA)of the two groups before and 3 months after the intervention were compared.Results The own condition,available social support,coping ability after discharge,disease knowledge and the total score of RHDS of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).There were no significant differences in BI index and FMA score between the two groups before intervention(P>0.05).The BI index and FMA score of the two groups after 3 months of intervention were higher than those before the intervention,the differences were statistically significant(P<0.05).The BI index and FMA score of the two groups after 3 months of intervention in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Before discharge,the total compliance rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The hospital discharge preparation plan for patients with hypertensive basal ganglia cerebral hemorrhage can effectively improve discharge preparation and compliance behavior,enhance motor function,and improve the ability of daily living.
2021 Vol. 28 (22): 86-88转92 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
89 Clinical effect of Aripiprazole combined with Sertraline in the treatment of non-suicidal self-injury with anxiety and depression in adolescents
SONG Jing-yao；WANG Gao-mao； LI Zhen-yang；GAO He；HE Xian-ping；ZENG Qiao-ling
Objective To investigate the clinical effect and safety of Aripiprazole combined with Sertraline in the treatment of non-suicidal self-injury(NSSI)combined with disease of anxiety and depression in adolescent patients.Methods A total of 80 adolescent NSSI patients combined with anxiety and depression admitted to University-Town Hospital of Chongqing Medical University from September 2018 to September 2019 were selected as the research objects.They were divided into control group(40 cases)and observation group(40 cases)according to the random number table method.The control group was treated with Sertraline alone,and the observation group was treated with Aripiprazole combined with Sertraline.The efficacy and safety of the two groups were evaluated by Hamilton depression scale 17(HAMD-17),Hamilton anxiety scale(HAMA)before treatment and at the end of 1,2 and 4 weeks of treatment,respectively and treatment emergent symptom scale(TESS).The occurrence of NSSI behavior was evaluated with Ottawa selfinjury inventory(OSI).Results The total effective rate of the observation group(97.5%)was higher than that of the control group(85.0%),with the statistically significant difference(P<0.05).The scores of HAMD-17,HAMA and the incidence of NSSI behavior in the observation group were lower than those in the control group at the end of 1,2 and 4 weeks of treatment,with statistically significant differences(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Aripiprazole combined with Sertraline is safe and effective in the treatment of NSSI combined with anxiety and depression in adolescent patients.
2021 Vol. 28 (22): 89-92 [Abstract] ( 41 ) HTML (39 KB)  PDF  (0 KB)  ( 6 )
93 Clinical effect of computer cognitive correction combined with medication on patients with mild cognitive impairment
YUAN Shui-lian； ZHONG Jing； GUO Long-run； ZHANG Guang-biao
Objective To explore the clinical effect of computer cognitive correction therapy in patients with mild cognitive impairment.Methods A total of 43 elderly patients with mild cognitive impairment who were treated in the Third People′s Hospital of Ganzhou City from July 2017 to July 2019 were selected as the research subjects,and they were divided into study group(21 cases)and control group(22 cases)according to the lottery method.The control group was given drug therapy,and the study group was given computer cognitive therapy combined with drug therapy.The changes of cognitive function and social function were compared between the two groups before and after intervention.Results Before intervention,there were no significant differences in the total scores and various scores of Montreal cognitive assessment scale(MOCA)and functional activities questionnaire(FAQ)between the two groups(P>0.05).After intervention,the total score of MOCA and the scores of visuospatial executive function,delayed recall and attention in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).After the intervention,the total score of FAQ and the scores of payment and bills,self shopping,attention and understanding,skill activities in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Computer cognitive correction therapy can effectively improve the cognitive function and social function of patients with mild cognitive impairment,and improve the therapeutic effect.
2021 Vol. 28 (22): 93-95转99 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
96 Influence of cognitive behavioral social skills training on quality of life and social function in elderly patients with schizophrenia
ZHANG Ying； CAO Shu-hua； KE Wen-ying；WEN Yan-wen
Objective To explore the cognitive behavioral social skills training on quality of life and social function in elderly patients with schizophrenia.Methods A total of 86 elderly patients with schizophrenia in Wu Zhongpei Memorial Hospital of Shunde District in Foshan City from December 2018 to December 2019 were selected and divided into experimental group and control group using the random number table method,43 cases in each group.The control group was given antipsychotic drug treatment and routine nursing intervention,while the experimental group was given cognitive behavioral social skills training on that basis.The scale of social function in psychosis inpatients(SSPI)and ability of daily living(ADL)were used to evaluate the changes of social function and quality of life of the patients before and after the intervention,and questionnaire was used to investigate the nursing satisfaction of the two groups.Results Before the intervention,there were no significant differences in the social function scores and SSPI total score between the two groups(P>0.05).After the intervention,the social function scores and SSPI total score of the two groups were higher than those before the intervention,and the social function scores and SSPI total score of the experimental group were higher than those of the control group,the differences were statistically significant(P<0.05).Before the intervention,there were no significant differences in all aspects of quality of life scores and ADL total score between the two groups(P>0.05).After the intervention,all aspects of quality of life scores and ADL total score of the two groups were lower than those before the intervention,and all aspects of quality of life scores and ADL total score of the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).The total nursing satisfaction rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The application of cognitive behavioral social skills training is helpful to improve the quality of life and social function of elderly patients with schizophrenia,and can improve nursing satisfaction,with good clinical effect.
2021 Vol. 28 (22): 96-99 [Abstract] ( 43 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
100 Application effect of Magnesium Valproate combined with situational communication training in patients with bipolar disorder
WAN Shao-lan； WEN Liang； ZHOU Wen-qiong
Objective To explore the application effect of Magnesium Valproate combined with situational communication training in patients with bipolar disorder.Methods A total of 58 patients with bipolar disorder in the Third People′s Hospital of Yichun,Jiangxi Province from March 2018 to February 2019 were selected as the research objects and divided into the control group and the observation group according to the random number table method,with 29 cases in each group.The control group received Lithium Carbonate Tablets for treatment,and the observation group received Magnesium Valproate Tablets for treatment.Both groups received continuous treatment for 3 months.Patients of both groups received situational communication training during treatment.The clinical efficacy after treatment between the two groups was compared,and the scores of Hamilton depression scale(HAMD),Bech-Rafaelsen mania rating scale(BRMS),and short form of 36(SF-36),the levels of uric acid(UA),tumor necrosis factor-α(TNF-α)and albumin of the two groups before and after treatment were compared.Results The total clinical effective rate in the observation group was 93.10%,which was higher than 68.97% in the control group,and the difference was statistically significant(P<0.05).After treatment,the BRMS score,HAMD score and serum TNF-α and UA levels of the two groups were lower than those before treatment,those in the observation group were lower than those in the control group,while the SF-36 score and serum albumin level were higher than those before treatment,those in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Magnesium Valproate combined with situational communication training can effectively reduce the degree of depression and mania in patients with bipolar disorder,and inhibit the inflammation in the body,improve the quality of life of the patients with better clinical efficacy.
2021 Vol. 28 (22): 100-102转106 [Abstract] ( 40 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )
103 Effect observation of Paroxetine combined with Olanzapine in the treatment of depression complicated with sleep disorder
YU Fang-zhou； HE Ru
Objective To explore the clinical effect of Paroxetine combined with Olanzapine in the treatment of depression complicated with sleep disorder.Methods A total of 180 patients with depression complicated with sleep disorder admitted to People′s Hospital of Liaoning Province from June 2018 to October 2020 were selected as the study subjects.After being uniformly numbered,they were divided into the conventional group(n=90)and the experimental group(n=90)according to the method of single and double numbers.The conventional group was treated with Paroxetine Tablets alone,while the experimental group was treated with Paroxetine combined with Olanzapine.The clinical efficacy,sleep quality,depression and sleep were compared between the two groups.Results The total effective rate of the experimental group after treatment was 94.44%,which was lower than 83.33% of the conventional group,and the difference was statistically significant(P＜0.05).There was no significant difference in the sleep quality and depression between the two groups before treatment(P＞0.05).After treatment,the scores of Hamilton depression scale(HAMD)and Pittsburgh sleep quality index(PSQI)in the experimental group were lower than those in the conventional group,the total sleep time in the experimental group was longer than that in the conventional group,the sleep latency,awakening time in the experimental group were shorter than those in the conventional group,awakening times in the experimental group was less than that in the conventional group,and the differences were statistically significant(P＜0.05).Conclusion The application of Paroxetine combined with Olanzapine in the treatment of depression complicated with sleep disorder can significantly improve the depression,sleep quality and sleep condition of patients,and also can improve the clinical total effective rate of patients,which is worthy of promotion and application.
2021 Vol. 28 (22): 103-106 [Abstract] ( 52 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )
107 Effect of intravenous thrombolysis with Alteplase on neurological function,coagulation parameters and prognosis in patients with acute cerebral infarction
WU Shou-xian； KE Yong-yuan
Objective To investigate the effect of intravenous thrombolysis with Alteplase on neurological function,coagulation parameters and prognosis in patients with acute cerebral infarction.Methods A total of 116 patients with acute cerebral infarction admitted to the Department of Emergency of the Second People′s Hospital of Foshan from January 2019 to June 2020 were selected as the research objects.According to the final treatment plan selected by the patient or his family,the patients were divided into the observation group(62 cases)and the control group(54 cases).The observation group was given intravenous thrombolytic therapy with Alteplase,and the control group was given conventional treatment for acute cerebral infarction.The National Institutes of Health stroke scale(NIHSS)scores before treatment,24 h and 14 d after treatment were compared between the two groups.The levels of prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)were compared between the two groups before and 24 h after treatment.The prognosis and incidence of adverse reactions were compared between the two groups.Results the NIHSS scores at 24 h and 14 d after treatment in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of PT,TT,APTT,FIB between the two groups before and 24 h after treatment(P>0.05).The prognosis of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Emergency intravenous thrombolysis with Alteplase can significantly improve the neurological function and prognosis of patients with acute cerebral infarction,and has little effect on coagulation function.
2021 Vol. 28 (22): 107-109转113 [Abstract] ( 41 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
110 Clinical effect of neuroendoscopic surgery combined with Naoxueshu Oral Solution in the treatment of spontaneous cerebral hemorrhage
LIAO Jin
Objective To investigate the clinical effect of neuroendoscopic surgery combined with Naoxueshu Oral Solution in the treatment of spontaneous cerebral hemorrhage.Methods A total of 72 patients with spontaneous intracerebral hemorrhage admitted to Wuhan Asia General Hospital Affiliated to Wuhan University of Science and Technology from November 2018 to November 2020 were selected as the research subjects and divided into control group(37 cases)and experimental group(35 cases)according to coin toss method.Both groups received neuroendoscopic cerebral hematoma removal,the control group received conventional treatment after surgery,the experimental group on the basis of the control group added Naoxueshu Oral Solution.The length of stay in the two groups was compared,and the Glasgow coma score(GCS),modified Rankin score(mRS)and Barthel index score were compared one month after surgery.Results The hospitalization time of the experimental group was shorter than that of the control group,the difference was statistically significant(P<0.05).There were no statistically significant differences in GCS,mRS and Barthel index scores between the two groups before surgery(P>0.05).One month after operation,the GCS score and Barthel index score of the experimental group were higher than those of the control group,while the mRS score was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion Neuroendoscopic cerebral hematoma removal combined with Naoxueshu Oral Solution treatment of spontaneous intracerebral hemorrhage can improve the prognosis of patients and shorten the length of hospital stay.
2021 Vol. 28 (22): 110-113 [Abstract] ( 35 ) HTML (37 KB)  PDF  (0 KB)  ( 8 )
114 Comparision effect between Aspirin and low-dose Argatroban in the treatment of acute cerebral infarction
YE Feng
Objective To compare the effect between Aspirin and low-dose Argatroban in the treatment of acute cerebral infarction.Methods From January 2017 to December 2019,90 patients with acute cerebral infarction admitted to the Iron Coal General Hospital of China Resources Liaojian Group were selected as the research objects.They were divided into group A and group B according to random number table method,with 45 cases in each group.On the basis of basic treatment,group A was treated with low-dose Argatroban,and group B was treated with Aspirin.The treatment course of both groups was 7 days.The clinical efficacy,the National Institutes of Health stroke scale(NIHSS)score and Barthel index score before and after treatment,the incidence of adverse reactions were compared between the two groups.Results The NIHSS scores of the two groups after treatment were lower than those before treatment,and the Bathel index of the two groups after treatment were higher than those before treatment,the differences were statistically significant(P<0.05).The NIHSS score of group A after treatment was lower than that of group B,and the Bathel index of group A after treatment was higher than that of group B,the differences were statistically significant(P<0.05).The total effective rate of group A was higher than that of group B,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Compared with Aspirin,low-dose Argatroban has better curative effect in the treatment of acute cerebral infarction,which has significant effect on improving the neurological function of patients and enhancing the ability of life autonomy,and is suitable for promotion.
2021 Vol. 28 (22): 114-116 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
117 Application of combined vibration and elliptical machine walking training in improving motor function of stroke patients with hemiplegia
YANG Zhong-fen

Objective To explore the application of vibration and elliptical machine walking training in improving motor function of stroke patients with hemiplegia.Methods A total of 120 patients with stroke and hemiplegia admitted to the Fifth People′s Hospital of Jingzhou City from January 2017 to January 2019 were selected as the research objects.They were divided into the conventional group and the improved group according to the random number table method,with 60 cases in each group.The conventional group was given regular rehabilitation training.The improved group was given vibration and elliptical walking training on the basis of conventional rehabilitation training.After 3 months of training,the motor function,balance ability,daily living ability and exercise endurance of the two groups were compared before and after training.Results There were no statistically significant differences between the two groups before training in Fugl-Meyer motor function scale,Berg scale,Barthel index(BI)and 6-minute walking test(6MWT)distance(P>0.05).After training,the Fugl-Meyer score,Berg score,BI and 6MWT in the two group were higher than those before training,and the differences were statistically significant(P<0.05).After training,the Fugl-Meyer score,Berg score,BI and 6MWT in the improved group were higher than those in the conventional group,and the differences were statistically significant(P<0.05).Conclusion Comprehensive rehabilitation training can better improve the motor function and balance performance of stroke patients,and improve the patients′ ability of daily living,and it has the advantages of being easy to carry out outside the hospital and long-term persistence
2021 Vol. 28 (22): 117-119转123 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
120 Effect of high frequency repetitive transcranial magnetic stimulation on cognitive function in alcohol-dependent patients
ZHANG Yun
Objective To investigate the effect of high frequency repetitive transcranial magnetic stimulation(rTMS)on cognitive function of alcohol dependent patients.Methods Forty-four male patients with alcohol dependence who were hospitalized in Shenyang Mental Health Center from January 2019 to June 2019 were selected as the research subjects,and randomly divided into study group(22 cases)and control group(22 cases)according to the hospitalization number,odd-even number.The study group received rTMS treatment and the control group received pseudo stimulation.Both groups were treated for 8 weeks.The mini-mental assessment scale(MMSE)and the Montreal cognitive assessment scale(MoCA)were used to assess patients′ cognitive status at baseline,4 and 8 weeks of treatment.Results Before treatment,there was no significant difference in MMSE and MoCA scores between the two groups(P>0.05).After 4 and 8 weeks of treatment,the MMSE and MoCA scores of the study group were higher than those of the control group,the differences were statistically significant(P<0.05).The MMSE and MoCA scores of the study group after 4 and 8 weeks of treatment were higher than those before treatment,while those of the control group after 8 weeks of treatment were higher than those before treatment,the differences were statistically significant(P<0.05).There were no obvious adverse reactions in the two groups.Conclusion rTMS can promote the cognitive function recovery of alcohol-dependent patients with high safety,which is worthy of clinical promotion and application.
2021 Vol. 28 (22): 120-123 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
124 Correlation analysis of the family resilience and the quality of life in patients on maintenance hemodialysis
FU Lian-ying； CHEN Shu-ling ；LIAO Ai-min
Objective To explore the correlation of the family resilience and the quality of life in patients on maintenance hemodialysis.Methods A total of 104 maintenance hemodialysis patients in Hospital of Integrated Traditional Chinese and Western Medicine of Jiangxi Province from January 2019 to September 2019 were selected as the research subjects.Questionnaire survey was adopted to investigate general information,family resilience and quality of life,and the correlation between family resilience and quality of life was observed and analyzed.Results The score of the quality of life was （358.55±159.98）points,and the score of family resilience was （94.75±12.33）points.Family flexibility of MHD patients was positively correlated with quality of life(r=0.313, P＜0.05).In the family flexibility,the family communication and problem-solving dimensions,and the positive view dimension were positively correlated with the quality of life(r=0.306,0.250, P＜0.05).Conclusion the family resilience is correlated with the quality of life in patients on maintenance hemodialysis.
2021 Vol. 28 (22): 124-126 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 8 )
127 Application of oblique lithotomy position in percutaneous nephrolithotomy
FU Xing； HUANG Kao-ping； JIANG Chun-qiang； WEN Shi-he
Objective To investigate the application effect of oblique lithotomy position in percutaneous nephrolithotomy(PCNL).Methods The clinical data of 95 patients with complex renal calculi in Department of Urology,People′s Hospital of Heyuan from January 2016 to August 2020 were retrospectively analyzed.According to the different positions of PCNL,the clinical data of 50 patients with PCNL in oblique supine lithotomy position guided by ultrasound were included in group A,and the clinical data of 45 patients with PCNL in traditional prone position guided by ultrasound were included in group B.The related operation indexes,postoperative fever rate and one-stage stone removal rate were compared between the two groups; the patients were followed up for 3 months after operation,and the incidence of postoperative complications was compared between the two groups during the follow-up period.Results The intraoperative blood loss of group A was less than that of group B,the time of body position,operation time and hospital stay of group A were shorter than those of group B,the differences were statistically significant(P<0.05); the stone clearance rate of group A was higher than that of group B,the fever rate of group A was lower than that of group B,the differences were statistically significant(P<0.05).The total complication rate of group A was lower than that of group B,the difference was statistically significant(P<0.05).Conclusion The effect of PCNL treatment in patients with renal calculi under the guidance of supine lithotomy position B ultrasound is better,which can reduce the amount of blood loss,shorten the time of placement position,operation time and hospitalization time,and can effectively improve the rate of primary stone clearance,reduce the incidence of postoperative complications and fever rate,with better surgical effect.
2021 Vol. 28 (22): 127-129 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
130 Clinical application of oblique supine lithotomy position and combined double endoscopy in the treatment of complex renal calculi in obese patients
HUANG Hai-wen； ZHU Chen-hui；HUANG Chang-qing； GAO Shao-qing； CHEN Song-ning； CHEN Wei-guang CAI Zhi-ren
Objective To explore the clinical application value of oblique supine lithotomy position and combined double endoscopy in the treatment of complex renal calculi in obese patients.Methods A total of 100 obese patients with complex renal calculi were treated and selected as the study subjects in Zhanjiang Central People′s Hospital from July 2018 to September 2020.They were divided into the control group and the observation group by the random number table method,with 50 cases in each group.Multi-channel percutaneous nephroscopy in prone position was performed in the control group,and flexible ureteroscope combined with single micro-channel percutaneous nephroscopy in oblique lithotomy position was performed in the observation group.The operation time,intraoperative blood loss,postoperative hospital stay,visual analogue scale(VAS)score,primary calculi clearance rate,intraoperative complications postoperative complications and the difference in the rate of renal artery embolization after surgery were compared between the two groups.Results The VAS score in the observation group was lower than that in the control group,the operation time and postoperative hospital stay were shorter than those in the control group,the intraoperative blood loss in the observation group was less than that in the control group,the differences were statistically significant(P<0.05).There was no statistical difference in the embolization rate of renal artery intervention between the two groups of patients(P>0.05).The primary calculi clearance rate in the observation group was higher than that in the control group,the incidence of intraoperative complications and the incidence of postoperative complications in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusions For the treatment of complex renal calculi in obese patients,the model of oblique supine lithotomy position and combined double endoscopy is a safe,effective,comfortable,and minimally invasive treatment method,which is better than the single endoscopic model,has the comfortable posture,less trauma,light postoperative pain,high rate of primary stone clearance,few intraoperative and postoperative complications,and the operation is convenient.The combined double endoscopy can be combined with antegrade or retrograde to treat calculus in the renal calyx,especially suitable for obesity patients according to the patient′s condition.It is worthy of clinical promotion and application.
2021 Vol. 28 (22): 130-134 [Abstract] ( 32 ) HTML (46 KB)  PDF  (0 KB)  ( 6 )
135 Change of prostate-specific antigen after anterior lobe preserved transurethral plasmakinetic enucleation of prostate
LIN Yang-yan； QIU Chun-ming ；YANG Yong； SUN Can-biao； ZHANG Guo-fei
Objective To investigate the changes of serum prostate-specific antigen(PSA)in patients with benign prostatic hyperplasia(BPH)after anterior lobe preserved transurethral plasmakinetic enucleation of prostate.Methods The clinical data of 85 patients with BPH who received anterior lobe preserved transurethral plasmakinetic enucleation in Nanhai Hospital of Southern Medical University from July 2017 to October 2020 were retrospectively analyzed.According to the size of prostate,they were divided into three groups:small group(<40 mL)20 cases,medium group(40-80 mL)49 cases and large group(>80 mL)16 cases.The serum PSA levels of patients in the three groups were compared before surgery,1,7 days after surgery,1,2 and 3 months after surgery.Results The PSA level of 85 patients on the first day after operation was higher than that before operation,with statistical significance(P<0.05).The PSA levels of the 1,7 day and 1 month after operation were compared with those of the previous time point,and the differences were statistically significant(P<0.05).There were no significant differences in PSA levels between 1,2 and 3 months after operation(P>0.05).The PSA levels before and 1 day after surgery were compared between three groups,and the differences were statistically significant(P<0.05).There were no significant differences in PSA levels between 7 days after surgery and 1,2 and 3 months after surgery(P>0.05).One month after surgery,the 95% value of PSA was 1.46 ng/mL.Conclusion There was no difference in the PSA levels of different volumes of prostate at one month after anterior lobe preserved transurethral plasmakinetic enucleation of prostate,and the PSA levels reached a stable level.The "baseline value" of PSA at one month after surgery was 1.46 ng/mL,which is helpful for the evaluation of the complete degree of BPH resection and the early detection of postoperative new prostate cancer.However,the "baseline value" may vary among patients with different BPH,and further study is needed.
2021 Vol. 28 (22): 135-138 [Abstract] ( 31 ) HTML (36 KB)  PDF  (0 KB)  ( 8 )
139 Effect of high permeable dialysis on calcium and phosphorus metabolism in elderly uremic patients
LIU Wei; XIAO Ping
Objective To investigate the effect of high permeable dialysis in elderly patients with uremia with abnormal calcium and phosphorus metabolism.Methods A total of 78 elderly patients with uremia admitted to Dalian Central Hospital from April 2019 to April 2020 were selected as the research subjects,and they were divided into the experimental group and the control group according to the random number table method,with 39 cases in each group.The experimental group was treated with high permeable dialysis,and the control group was treated with conventional hemodialysis.The treatment effect,calcium and phosphorus metabolism indexes,inflammatory factors and complications were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).After 6 months of treatment,the levels of parathyroid hormone,blood phosphorus,and blood creatinine of the test group were lower than those of the control group,and the blood calcium level was higher than that of the control group,the differences were statistically significant(P<0.05).The levels of interleukin-6 and C-reactive protein in the experimental group after 6 months were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of complications in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The effect of high permeable dialysis treatment in elderly patients with uremia with abnormal calcium and phosphorus metabolism can not only significantly improve the symptoms,but also reduce complications.It is worthy of further promotion and application in clinical practice.
2021 Vol. 28 (22): 139-142 [Abstract] ( 28 ) HTML (37 KB)  PDF  (0 KB)  ( 9 )
143 Research on the relationship between serum 25(OH)D3 level and metabolic syndrome in middle-aged and elderly people in Hulunbuir area
DING Li-ping； SONG Li-gang； LI Yi-xin； LIU Zi-qi； ZHOU Ming-shuang； ZHOU Fei；ZHANG Xue
Objective To explore the relationship between serum 25-hydroxyvitamin D3[25(OH)D3]levels and metabolic syndrome(MS)in the elderly in Hulunbuir area.Methods A total of 2145 MS patients who were admitted to the Hulunbuir People′s Hospital of Inner Mongolia from January 2017 to August 2019 were selected as the observation group,and 684 non-MS patients treated in Hulunbuir People′s Hospital of Inner Mongolia during the same period were selected as the control group.The body mass index(BMI),systolic blood pressure,diastolic blood pressure,blood biochemical indexes[25(OH)D3,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),uric acid(UA),and glycated hemoglobin(HbA1c)]were compared between the two groups,the correlation between 25(OH)D3 in the observation group and BMI,systolic blood pressure,diastolic blood pressure and blood biochemical indexes was analyzed,and the 25(OH)D3 levels in the two groups were compared.Results The BMI,LDL-C,TC,TG,HbA1c,FBG,systolic blood pressure and diastolic blood pressure of in observation group were higher than those in control group,and 25(OH)D3 was lower than that in the control group,the differences were statistically significant(P<0.05); There were no significant differences in HDL-C and UA between the two groups(P>0.05).The 25(OH)D3 level in the observation group was negatively correlated with BMI,HbA1c,FBG,diastolic blood pressure,LDL-C and systolic blood pressure(P＜0.05).The proportions of 25(OH)D3≤20 ng/mL and >20～30 ng/mL in observation group were higher than those in control group,and the proportions of 25(OH)D3> 30 ng/mL were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion The serum 25(OH)D3 level is relatively insufficient in the middle-aged and elderly MS patients in Hulunbuir area,and its level is closely related to BMI,HbAlc,FBG,diastolic blood pressure,LDL-C,and systolic blood pressure.The decrease of 25(OH)D3 level may be related to MS Happened related.
2021 Vol. 28 (22): 143-146 [Abstract] ( 45 ) HTML (38 KB)  PDF  (0 KB)  ( 8 )
147 Application of family doctor model in follow-up management of patients with type 2 diabetes
YU Ming; XIAO Qiu-yan; NIE Lei
Objective To explore the application effect of family doctor model in follow-up management of patients with type 2 diabetes(T2DM).Methods From January 2018 to January 2019,210 patients with T2DM who had established residents′ health records in the social health records of Huazhong University of Science and Technology Union Shenzhen Hospital from January 2018 to January 2019 were selected as the study subjects.According to random number table method,they were divided into control group and observation group,with 105 patients in each group.The control group received routine follow-up management,and the observation group received follow-up management under the family doctor mode.The blood glucose,treatment compliance,and quality of life were compared between the two groups.Results After 1 year of intervention,the levels of fasting blood glucose,2 h postprandial blood glucose,and glycosylated hemoglobin(HbA1c)of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).After 1 year of intervention,the diabetes treatment compliance score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The quality of life scores of the observation group were higher than those of the control group after 3,6,and 9 months of intervention and 1 year after intervention,and the differences were statistically significant(P<0.05).Conclusion The family doctor model used in the follow-up management of T2DM patients can improve their compliance,control blood sugar levels more effectively,and improve their quality of life.
2021 Vol. 28 (22): 147-150 [Abstract] ( 43 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
151 Analysis of the effect of Zoledronic Acid combined with Simvastatin in the treatment of patients with type 2 diabetes and osteoporosis
WU Bo; XIE Ming
Objective To analyse the effect of Zoledronic Acid combined with Simvastatin in the treatment of patients with type 2 diabetes(T2DM)and osteoporosis.Methods A total of 64 patients with T2DM and osteoporosis admitted to the Second People′s Hospital of Zhaoqing from October 2018 to July 2019 were selected as the research subjects.They were divided into the combination group(32 cases)and the single-drug group(32 cases)according to the odd and even number grouping method.The single-drug group was treated with Zoledronic Acid,and the combination group was treated with Simvastatin on the basis of the single-drug group.The clinical bone pain symptoms,bone biochemical indicators,density of different parts of the bone,and adverse reactions between the two groups were compared.Results The clinical bone pain symptoms of the combination group were milder than those of the single-drug group,and the differences were statistically significant(P<0.05).There were no significant differences in serum osteocalcin(BGP),bonespecific alkaline phosphatase(BALP),osteoprotegerin(OPG)and blood phosphorus(P)between the two groups before treatment(P>0.05).After 8 months of treatment,the levels of BGP and BALP of the two groups were lower than those before treatment,and those indicators in the combination group were lower than those of the single-drug group; the levels of OPG and phosphorus were both higher than those before treatment,and the two indicators in the combination group were higher compared with those in the single-drug group,and the differences were statistically significant(P<0.05).There were no significant differences in the bone mineral density of the lumbar spine,femoral neck and Ward triangle between the two groups before treatment(P>0.05); after 8 months of treatment,the bone mineral density of the lumbar spine,femoral neck and Ward triangle of the two groups were all higher than those before treatment,and the combination group was higher than that in the group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions after treatment in the combined group was lower than that in the single-drug group,and the difference was statistically significant(P<0.05).Conclusion The combination of Simvastatin and Zoledronic Acid in the treatment of patients with T2DM and osteoporosis can improve their bone biochemical indicators,increase bone density,and reduce bone pain symptoms and adverse drug reactions.
2021 Vol. 28 (22): 151-154 [Abstract] ( 45 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
155 Clinical application effect of ultrasound-guided precision caudal block in children with inguinal strangulated hernia
LIN Min; WU Yue; LIU Yu-qing
Objective To explore the clinical application effect of ultrasound-guided precision sacral canal block in children with inguinal strangulated hernia.Methods A total of 60 children with inguinal strangulated hernia admitted to Jiujiang Maternal and Child Health Hospital from February 2019 to August 2020 were selected as the research objects and divided into the control group(30 cases)and the study group(30 cases)according to the random table method.All of the children were treated with inguinal strangulated hernia,and interposed with the anesthesia of Sevoflurane under laryngeal mask ventilation combined with caudal block.The control group was given the traditional caudal block,and the study group was given ultrasound-guided precision caudal block.The puncture status,vital signs,adverse events and complications of the two groups were compared.Results The puncture time of the study group was shorter than that of the control group,the number of punctures was fewer than that of the control group,the first puncture success rate was higher than that of the control group,and the differences were statistically significant(P<0.05).After induction of anesthesia and at the end of the operation,there were no significant differences in heart rate and blood pressure between the two groups or within the groups(P>0.05).There were no statistically significant differences in the incidence of adverse events and complications between the two groups(P>0.05).Conclusion The use of ultrasound-guided precision sacral canal block for pediatric incarcerated hernia has a good anesthesia effect,which can shorten the puncture time,increase the success rate of puncture,reduce the number of punctures,and does not increase the incidence of adverse events and complications,and has high safety.
2021 Vol. 28 (22): 155-157 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
158 Application of combined spinal-epidural anesthesia in hysteroscopic surgery
ZHOU Yu-feng； LIANG Jin-ying
Objective To explore the application of combined spinal-epidural anesthesia in hysteroscopy surgery.Methods Eighty patients who received hysteroscopic surgery in Dongguan Qishi Hospital from September 2018 to September 2019 were retrospectively analyzed.They were divided into control group(40 cases)and observation group(40 cases)according to different anesthesia regimen.The control group received intravenous general anesthesia,and the observation group received combined spinal-epidural anesthesia.Anesthesia indicators,recovery assessment,changes in signs,pain,postoperative indicators and the total incidence of complications were compared between the two anesthesia methods.Results The onset time of anesthesia and the completion time of anesthesia block in observation group were shorter than those in control group,with statistically significant differences(P<0.05).The eye opening time of call,directional force recovery time and postoperative consciousness recovery time in observation group were shorter than those in control group,with statistically significant differences(P<0.05).Before anesthesia,there were no significant differences in the physical signs(heart rate[HR],mean arterial pressure[MAP])levels between the two groups(P>0.05).After anesthesia,HR and MAP in the two groups were lower than those before anesthesia,the differences were statistically significant(P<0.05).When the surgery started,HR levels in both groups were higher than those before anesthesia,MAP levels were lower than those before anesthesia,the differences were statistically significant(P<0.05).At the same time,visual analogue scale(VAS)of pain at 10 min after waking in observation group was lower than that in the control group,the difference was statistically significant(P<0.05).In addition,the anal exhaust time,bowel sound recovery time and postoperative bed rest time in observation group were shorter than those in control group,the differences were statistically significant(P<0.05).The total incidence of complications in observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Combined spinal-epidural anesthesia is feasible and safe in the course of hysteroscopy.
2021 Vol. 28 (22): 158-161转165 [Abstract] ( 44 ) HTML (43 KB)  PDF  (0 KB)  ( 8 )
162 Application effect of epidural block with dural perforation in parturient analgesia
CHEN Qiu-yue; CHEN Wen-yu; GUAN Ze-xiong
Objective To investigate the effect of epidural puncture(DPE)block in parturient labor analgesia.Methods A total of 325 cases of full-term diparas who were admitted to Yangjiang Maternal and Child Health Hospital from January 2019 to October 2020 were selected as the research subjects,and divided into DPE group(170 cases)and EP group(155 cases)according to the method of coin toss.DPE group received epidural puncture anesthesia,and EP group received epidural anesthesia.The incidence of analgesic complications,visual analogue scale(VAS)score,the number of analgesic pump compressions(PCA)and the degree of lower limb motor nerve block(Bromage)score were compared between the two groups.Results The incidences of complications as fetal heart abnormality,prenatal fever,skin itching,dysuria and postpartum headache in DPE group were lower than those in EP group,and the differences were statistically significant(P<0.05).VAS score of DPE group were lower than those of EP group at different stages of delivery,the differences were statistically significant(P<0.05).PCA pressing frequency of DPE group was lower than that of EP group,and Bromage score was lower than that of EP group,the differences were statistically significant(P<0.05).Conclusion DPE block technique has obvious effect and high safety in childbirth analgesia,which is worthy of clinical application and promotion.
2021 Vol. 28 (22): 162-165 [Abstract] ( 42 ) HTML (35 KB)  PDF  (0 KB)  ( 5 )
166 Effect of Remifentanil combined with Sevoflurane on hemodynamics in elderly patients undergoing bone and joint replacement
XIAO Ti-song; CHEN Guo-dong; DENG Hai-yan
Objective To investigate the effect of Remifentanil combined with Sevoflurane on hemodynamics in elderly patients undergoing bone and joint replacement.Methods A total of 60 elderly patients undergoing bone and joint replacement in the Department of Anesthesiology,Jiangmen Xinhui District Hospital of Traditional Chinese Medicine from January 2019 to September 2020 were selected as the research objects.They were divided into control group(30 cases)and study group(30 cases)by random number table method.The control group was anesthetised with Sufentanil combined with Sevoflurane,and the study group was anesthetised with Remifentanil combined with Sevoflurane.Hemodynamic changes at different time points,time of loss of consciousness,awakening and extubation,Ramsay sedation score,OAA/S score 10 min after surgery and the incidence of adverse reactions between two groups were compared.Results Before operation(T0),there were no significant differences in heart rate(HR)and mean arterial pressure(MAP)between the two groups(P>0.05).The levels of HR and MAP in the study group were lower than those in the control group at the completion of induced anesthesia(T1),the beginning of surgery(T2),5 min before the end of surgery(T3),and 10 min after the end of surgery(T4),the differences were statistically significant(P<0.05).The time of loss of consciousness,awakening and extubation in the study group was shorter than that in the control group,the differences were statistically significant(P<0.05).Ramsay score in the study group was higher than that in the control group,and OAA/S score 10 min after surgery was lower than that in the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Remifentanil combined with Sevoflurane to maintain anesthesia in elderly patients with bone and joint replacement surgery is beneficial to stabilize hemodynamics,and the anesthesia effect is good and relatively safe.
2021 Vol. 28 (22): 166-169 [Abstract] ( 43 ) HTML (39 KB)  PDF  (0 KB)  ( 7 )
170 Influence on Dezocine combined with Sufentanil on postpartum analgesia effect and postpartum depression after cesarean section
YU Hong-tian; LI Yi-ling; PENG Li-yun
Objective To investigate the influence on Dezocine combined with Sufentanil on postpartum analgesia effect and postpartum depression after cesarean section.Methods A total of 120 parturients who underwent cesarean section in the Maternal and Child Health Care Hospital of Longgang District in Shenzhen City from July 2019 to June 2020 were selected.According to the double-blind randomized trial design,they were divided into observation group and control group,with 60 parturients in each group.After the operation,both groups of patients used analgesic pumps.The observation group used Dezocine combined with Sufentanil for analgesia,and the control group only used Sufentanil for analgesia.The visual analogue scale(VAS)and Ramsay sedation score were used to evaluate postoperative analgesia and sedation in the two groups.The incidence of adverse reactions in the two groups was statistically analyzed.Edinburgh postnatal depression scale(EPDS)was used to evaluate the scores of maternal depression in the two groups.Results The VAS pain score at 24 h after surgery in the observation group was higher than that at 12 h after surgery,and the difference was statistically significant(P<0.05).There was no significant difference between the VAS pain scores at 36 h after surgery and 12 h after surgery in the observation group(P>0.05).The VAS pain score at 36 h after surgery was lower than that at 12 h after surgery in the control group,and the difference was statistically significant(P<0.05).There was no significant difference between the VAS pain scores at 24 h after surgery and 12 h after surgery in the control group(P>0.05).The VAS pain scores of the observation group at 12,24 and 36 h after surgery were lower than those of the control group,with statistically significant differences(P<0.05).At 24 and 36 h after surgery,Ramsay sedation scores of the two groups were lower than those of 12 h after surgery,the differences were statistically significant(P<0.05).Ramsay sedation scores of observation group at 12,24 and 36 h after surgery were higher than those of control group,with statistically significant differences(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The EPDS scores of observation group at 4 and 6 weeks postpartum were higher than those at 2 weeks postpartum,and the differences were statistically significant(P<0.05).There were no significant differences in EPDS scores between the control group at 4,6 weeks postpartum and 2 weeks postpartum(P>0.05).EPDS scores of the observation group were lower than those of the control group at 2 and 4 weeks postpartum,the differences were statistically significant(P<0.05).At 6 weeks postpartum,there was no significant difference in EPDS scores between the two groups(P>0.05).Conclusion Dezocine combined with Sufentanil has a strong analgesic and sedative effect.There is no need to increase the dose for analgesia after surgery,and it will not be excessively sedated.At the same time,the combination of Dezocine and Sufentanil may reduce the incidence of postpartum depression in the short term.
2021 Vol. 28 (22): 170-173 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
174 Application value of echocardiography in the diagnosis of chronic heart failure with multiple causes
WU Zhao-lan
Objective To explore the application value of echocardiography in the diagnosis of chronic heart failure with multiple causes.Methods From January 2019 to November 2020,113 cases of patients suspected with multiple causes of chronic heart failure in Ji′an Hospital of Shanghai Oriental Hospital were examined by conventional electrocardiogram,Holter and echocardiography.According to the clinical comprehensive diagnosis results,the diagnostic results of conventional electrocardiogram,Holter and echocardiography were compared,and the echocardiography indexes of patients with chronic heart failure and non chronic heart failure were compared.Results In the diagnosis of chronic heart failure,the sensitivity,specificity,accuracy,positive predictive value and negative predictive value of Holter and echocardiography were higher than those of conventional electrocardiogram,the differences were statistically significant(P＜0.05).There were no significant differences in the sensitivity,specificity,accuracy,positive predictive value and negative predictive value between Holter and echocardiography(P＞0.05).The left ventricular ejection fraction(LVEF)and ratio of peak early to late diastolic filling velocity of the left ventricular(E/A)values of patients with chronic heart failure were lower than those of patients without chronic heart failure,and the left ventricular end diastolic volume(LVEDV),left ventricular end systolic volume(LVESV)and Tei index of patients with chronic heart failure were higher than those of patients without chronic heart failure,and the differences were statistically significant(P＜0.05).Conclusion Echocardiography has good diagnostic value in the diagnosis of chronic heart failure with multiple causes,and which can be used to judge chronic heart failure by detecting LVEF,E/A value,Tei value and other indicators.
2021 Vol. 28 (22): 174-176 [Abstract] ( 45 ) HTML (29 KB)  PDF  (0 KB)  ( 5 )
177 Application of contrast-enhanced ultrasound combined with renal dynamic imaging in early chronic renal failure
TAO Xu-chang； WANG Hao
Objective To study the application effect of contrast-enhanced ultrasound(CEUS)combined with renal dynamic imaging in early chronic renal failure(CRF).Methods A total of 68 patients with early CRF who were treated in the First Hospital of Nanchang City from September 2019 to September 2020 were selected as the case group,and 40 healthy volunteers who had physical examination in the same period were selected as the control group.The clinical data of all subjects were studied,and the ascending branch slope parameter(A),descending branch slope parameter(α),derived peak intensity(DPI),area under the curve(AUCTIC)of time-intensity curve(TIC),time to peak(TTP),renal blood perfusion index(PI)and glomerular filtration rate(GFR)of both kidneys were compared between the two groups.Receiver operating characteristic(ROC)curve was used to evaluate the diagnostic efficacy of the above indicators in the quantitative diagnosis of early CRF.Results The DPI of the case group was lower than that of the control group(P＜0.05),and the A,AUCTIC and PI of both kidneys of the case group were greater than those of the control group(P＜0.05),and the TTP of the case group was longer than that of control group(P＜0.05).There were no significant differences in α and GFR between the two groups(P＞0.05).The AUC of ROC curve,sensitivity and specificity of CEUS combined with renal dynamic imaging were 0.968(95%CI=0.943-0.994),91.20% and 90.00%.Conclusion CEUS combined with quantitative parameters of renal dynamic imaging has high accuracy in the early diagnosis of CRF,which can provide a more objective and accurate clinical basis for diagnosis and treatment decisions.
2021 Vol. 28 (22): 177-179转183 [Abstract] ( 32 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
180 Clinical value of ultrasound combined with vaginal injection of physiological saline in the diagnosis of vaginal foreign bodies in young girls and unmarried women
XIAO Xiao-fang;MIAO Qi; LIN Qiong
Objective To explore the clinical value of ultrasound combined with vaginal injection of physiological saline in the diagnosis of vaginal foreign bodies in young girls and unmarried women.Methods A total of 64 patients with vaginal foreign bodies treated in Ganzhou Maternal and Child Health Hospital were selected as the observation subjects from October 2017 to November 2020.All patients underwent ultrasound examination and vaginal injection of physiological saline.The diagnosis results of ultrasound examination(single detection)and ultrasound combined with vaginal injection of physiological saline(combined detection)were comparatively analyzed.The confirmation rate of foreign bodies was compared between the two detection methods.Results Among the 64 patients with vaginal foreign bodies,vaginal bleeding and abnormal secretions were the most common reasons for visits,with the incidence rate of 79.69%.Abdominal ultrasound examination showed that there were abnormal echoes such as strong echoes in both single detection and combined detection,and the causes of which could not be confirmed by single detection,while all causes could be confirmed by combined detection.The confirmation rate of vaginal foreign bodies of the combined detection was 100.00%,which was higher than 87.50% of single detection,the difference was statistically significant(χ2=8.533,P<0.05).Conclusion Ultrasound combined with vaginal injection of physiological saline is more accurate in the diagnosis of vaginal foreign bodies in young girls and unmarried women,and there are no adverse events,which is of higher clinical value.
2021 Vol. 28 (22): 180-183 [Abstract] ( 38 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
184 Application study of ultrasound in extubation of PICC
XIONG Mei-e; LIU Rong; CHEN Qing
Objective To analyze the application value of ultrasound in peripherally inserted central catheter(PICC)extubation.Methods A total of 60 PICC extubation patients who were admitted to the Department of Oncology of the Second People′s Hospital of Pingxiang City in Jiangxi Province from September 2018 to September 2020 were selected and divided into the control group and the observation group according to different research methods,30 cases in each group.The control group patients received conventional extubation in the process,the observation group underwent ultrasound exploration during extubation.The occurrence of extubation complications,patient satisfaction,and one-time extubation success rate between the two groups were compared.Results The one-time extubation success rate of the observation group was 96.67%,which was higher than 73.33% of the control group,the difference was statistically significant(P<0.05).The total extubation complication rate of the observation group was 13.33%,which was lower than 60.00% of the control group,the difference was statistically significant(P<0.05).The total nursing satisfaction rate of the observation group was 90.00%,which was higher than 66.67% of the control group,the difference was statistically significant(P<0.05).Conclusion Ultrasound examination during PICC extubation can help nurses assess vascular conditions and extubation conditions,thereby reduce the risk of extubation complications,and help to build a harmonious nurse-patient relationship.
2021 Vol. 28 (22): 184-186 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 5 )
187 Effect of transvaginal color Doppler ultrasonography of uterine scar healing on redelivery guidance and pregnancy outcome
CHEN Wei； CHEN Bao-ming； HU Jing ；ZENG Wen-jie
Objective To explore the effect of transvaginal color Doppler ultrasonography of uterine scar healing on redelivery guidance and pregnancy outcome.Methods A total of 70 cases of pregnant women who were admitted to Ji′an Central People′s Hospital of Jiangxi Province from May 2019 to August 2020 were selected as the research objects,and were divided into the control group(35 cases)and the observation group(35 cases)according to the examination methods.The control group was treated with abdominal color Doppler ultrasonography,and the observation group was treated with vaginal color Doppler ultrasonography on the basis of the former.The displaying rates of uterine scar,thickness of lower uterine segment,delivery modes and pregnancy outcomes of the two groups were detected and compared.Results The scar displaying rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The thickness of lower uterine segment of different grades in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The rate of natural delivery in the observation group was higher than that in the control group,while the rates of neonatal asphyxia,incomplete uterine rupture and massive postpartum hemorrhage in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).Conclusion The application of abdominal combined with vaginal ultrasonography for uterine scar healing has a more prominent effect,which effectively provides scientific guidance for clinical childbirth and improves the outcome of childbirth.
2021 Vol. 28 (22): 187-189转193 [Abstract] ( 41 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
190 Clinical effect of Pantoprazole combined with Amoxicillin in treatment of dyspepsia caused by Helicobacter pylori infection
XUE Yuan; LIU Hai-yan ;ZHANG Wei-jin
Objective To investigate the clinical effect of Pantoprazole combined with Amoxicillin in treatment of dyspepsia caused by Helicobacter pylori infection.Methods A total of 136 patients with dyspepsis caused by Helicobacter pylori infection who were sent to the Third Stationed Outpatient Department of the 988th in Hospital of the People′s Liberation Army Joint Logistics Support Force from August 2019 to August 2020 were selected as the research subjects.They were divided into control group and observation group by random number table method,with 68 cases in each group.Control group was treated with single drug Pantoprazole,and observation group was treated with Pantoprazole combined with Amoxicillin.The total effective rate,scores of symptoms(epigastric pain,abdominal distention,belching,acid regurgitating)after treatment and the total incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).The scores of various symptoms(upper abdominal pain,abdominal distension,belching,and acid return)in the observation group after treatment were lower than those in the control group,with statistically significant differences(P<0.05).The total incidence of adverse events in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).Conclusion Amoxicillin has a strong bactericidal effect,Amoxicillin combined with Pantoprazole has a better therapeutic effect and improves the quality of life of patients in the treatment of dyspepsia caused by Helicobacter pylori infection.The incidence of adverse events is also low.It is worthy of clinical promotion and application.
2021 Vol. 28 (22): 190-193 [Abstract] ( 30 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
194 Clinical effect of Linezolid combined with Cycloserine in the treatment of patients with multi-drug resistant pulmonary tuberculosis
ZENG An-jin； FAN Tian-qiong； YANG Cheng-ming； CHENG Shi-si； WANG Jie
Objective To observe the clinical effect of Linezolid combined with Cycloserine in the treatment of patients with multi-drug resistant pulmonary tuberculosis(MDR-PTB).Methods Eighty-four MDR-PTB patients who were hospitalized or outpatient in Jingzhou Chest Hospital from March 2017 to December 2019 were selected as the research subjects.According to random number table method,the patients were divided into two groups,with 42 cases in each group.Patients in both groups received basic treatment.Patients in the control group were additionally treated with Cycloserine,and patients in the observation group were additionally treated with Linezolid.The total effective rate,improvement time of clinical symptoms and the occurrence of adverse drug reactions were compared between the two groups.Results The total effective rate of observation group(88.10%)was higher than that of control group(66.67%),and the difference was statistically significant(P<0.05).The reduction time of focus volume,the time of sputum culture turning negative,the time of acid-fast staining smear turning negative and the time of cavity closing in the observation group were all shorter than those in the control group,with statistically significant differences(P<0.05).There was no statistical significance in the total incidence of adverse drug reactions between the two groups during treatment(P>0.05).Conclusion The treatment of Linezolid combined with Cycloserine for MDR-PTB patients has a significant effect.It can improve clinical symptoms,and it will not increase the incidence of adverse drug reactions.
2021 Vol. 28 (22): 194-196转200 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
197 Effect of Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction and its influence on high sensitivity Creactive protein
DONG Dan； HAN Lin-shan
Objective To investigate the effect of Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction and its influence on the level of hypersensitive C-reactive protein(hs-CRP).Methods Ninety-two patients with acute myocardial infarction admitted to the Central Hospital Affiliated to Shenyang Medical College from March 2017 to July 2018 were selected as the research subjects,and they were divided into observation group and control group according to random number table method,with 46 patients in each group.The two groups were treated with intravenous pumping Urokinase 30 minutes after admission,the control group was treated with Aspirin,and the observation group was combined with Clopidogrel on the basis of the control group.After treatment,the patients were followed up for 3 months.The blood coagulation function,hs-CRP levels and the incidence of cardiovascular events in the two groups were compared.Results The prothrombin time(PT)and activated partial thromboplastin time(APTT)of the observation group at 1 month after treatment were longer than those of the control group,and the fibrinogen(FIB)level was lower than that of the control group(P<0.05); the hs-CRP levels of the observation group at 1,2 and 3 months after treatment were lower than those of the control group(P<0.05); the incidence rates of myocardial infarction,angina pectoris,heart failure,arrhythmia and mortality in the observation group were lower than those in the control group(P<0.05).Conclusion Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction can significantly improve the coagulation function,significantly reduce the level of hs-CRP,and reduce the risk of cardiovascular events,which is worthy of popularization and application.
2021 Vol. 28 (22): 197-200 [Abstract] ( 40 ) HTML (36 KB)  PDF  (0 KB)  ( 6 )
201 Effect of Sijunzi Decoction combined with Western medicine on inflammatory reaction and rehabilitation of burn patients
GAO Ming-long； ZHENG Kai； LIU Yu-yu
Objective To explore the effect of Sijunzi Decoction combined with Western medicine on inflammatory reaction and rehabilitation of burn patients.Methods A total of 64 burn patients admitted to the Second Department of Surgery,Guixi Hospital of Traditional Chinese Medicine from January 2018 to December 2019 were selected as the research subjects.They were divided into the control group and the study group by random number table method,with 32 patients in each group.The control group was treated with Western medicine,and the study group was treated with Sijunzi Decoction on the basis of the control group.The clinical efficacy,traditional Chinese medicine syndrome score before and after treatment,serum inflammatory factor(interleukin-2[IL-2],interleukin-6[IL-6],interleukin-10[IL-10],tumor necrosis factor-α[TNF-α])levels and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 93.75%,higher than 50.00% of the control group,and the difference was statistically significant(P<0.05).After treatment,the traditional Chinese medicine syndrome score of the study group was(3.77±0.84)points,lower than(7.92±0.86)points of the control group,and the difference was statistically significant(P<0.05).After treatment,the level of IL-6 in the study group was(202.16±17.54)mg/L,and the level of TNF-α was(38.90±13.06)mg/L,which were lower than those in the control group([232.64±16.31],[57.24±12.13]mg/L),IL-2 level was(5.19±0.93)mg/L,IL-10 level was(90.42±6.73)mg/L in the study group,which were higher than those in the control group([4.31±0.85),[85.43±6.17]mg/L),and the differences were statistically significant(P<0.05).There were no serious adverse reactions in the two groups.Conclusion Sijunzi Decoction combined with Western medicine in the treatment of burn can effectively relieve the clinical symptoms and regulate the levels of inflammatory factors without serious adverse reactions.
2021 Vol. 28 (22): 201-204 [Abstract] ( 40 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )
205 Clinical effect of Daqinjiao Decoction combined with Butyphthalide in the treatment of acute cerebral infarction of wind phlegm blocking collaterals
CHEN Jie-fu；YU Le-duan； LOU Qing
Objective To observe the clinical effect of Daqinjiao Decoction combined with Butyphthalide in the treatment of acute cerebral infarction with wind phlegm blocking collaterals.Methods A total of 80 patients of acute cerebral infarction with wind phlegm blocking collaterals were selected as the research objects,and they were divided into the control group and the observation group according to random number table method,with 40 cases in each group.The control group was given conventional treatment.On the basis of the control group,the observation group was given Daqinjiao Decoction,Butylphthalide Sodium Chloride Injection was given intravenously in the first and second weeks,and Butylphthalide Soft Capsules was given orally in the third and fourth weeks.Both groups were treated for 1 month.The treatment effect,National Institutes of Health stroke scale(NIHSS)scores,ability to live daily(Barthel index)and the incidence of adverse reactions before and after treatment were compared between the two groups.Results There were no statistically significant differences in the NIHSS score and Barthel index between the two groups before treatment(P>0.05).The NIHSS score of the observation group after treatment was lower than that of the control group,Barthel index of the observation group after treatment was higher than that of the control group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Daqinjiao Decoction combined with Butylphthalide in the treatment of acute cerebral infarction of wind phlegm blocking collaterals type can reduce the symptoms of neurological deficit,improve the quality of life,and has definite curative effect,which is worthy of promotion.
2021 Vol. 28 (22): 205-207转211 [Abstract] ( 44 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
208 Application of modified Qinggan Huashi Huoxue Decoction combined with Polyene Phosphatidyl Choline in patients with alcoholic fatty liver
ZHANG Dong
Objective To explore the application of modified Qinggan Huashi Huoxue Decoction combined with Polyene Phosphatidyl Choline in patients with alcoholic fatty liver.Methods A total of 200 patients with alcoholic fatty liver who were diagnosed and treated in Chest Hospital of Jingzhou City,Hubei Province from November 2017 to November 2019 were selected as the study objects.The patients were divided into the study group and the control group by random number table method,with 100 cases in each group.The control group was treated with Polyene Phosphatidyl Choline,and the study group was treated with modified Qinggan Huashi Huoxue Decoction on the basis of the control group.Therapeutic effect,liver function indexes(alanine aminotransferase[ALT],aspartate aminotransferase[AST]and γ-glutamine transpeptidase[GGT]),blood lipid level(total cholesterol[TC],triglyceride[TG]),serum fibrinogen protein 1(FLP1),type Ⅲprocollagen peptide(PⅢP)level were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of ALT,AST,GGT,TC and TG in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the FLP1 in the study group was higher than that in the control group,and the PⅢP was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion Modified Qinggan Huashi Huoxue Decoction combined with Polyene Phosphatidyl Choline is effective in the treatment of alcoholic fatty liver.It can obviously improve the metabolism of blood lipid and liver function,and reduce the degree of liver fibrosis.
2021 Vol. 28 (22): 208-211 [Abstract] ( 48 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
212 Correlation of psychosocial adjustment,self-efficacy and coping style in patients with colorectal cancer
LIU Ke-hua； HE Qiong； NING Hui-wen；GAI Yao；CAO Hai-yan
Objective To explore the level of psychosocial adjustment in patients with colorectal cancer,and to analyze its correlation with self-efficacy and coping styles.Methods A total of 174 patients with colorectal cancer who were hospitalized in Shenzhen Second People′s Hospital from August 2019 to July 2020 were selected as the research objects and surveyed using the general information questionnaire,self-reported psychosocial adjustment to illness scale,general self-efficacy scale and medical coping modes questionnaire.Results The patient′s psychosocial adjustment score was(52.59±19.64)points,the average score of each dimension item from the highest to the bottom were entertainment,psychological status,work ability,health care,sexual relations,communication,and family relations.General self-efficacy score was(24.51±7.50)points,which was close to the median score of 26 points on the scale; facing dimension score was(18.25±4.20)points,avoidance dimension score was(15.51±4.18)points,yield dimension score was(10.17±3.62)points; facing dimension score was lower than that in the norm,avoidance and yield dimension scores were higher than those in the norm,the differences were statistically significant(P＜0.05); The psychosocial adjustment score was negatively correlated with the self-efficacy score and facing dimension score(r=-0.417,-0.435, P<0.05),and positively correlated with the avoidance and yield dimension scores(r=0.484,0.505, P<0.05).Conclusion The psychosocial adjustment of patients with colorectal cancer is at a moderate level.Medical staff should pay attention to improving the self-efficacy of patients,promoting patients to actively face the disease,so as to improve the psychosocial adjustment level of patients.
2021 Vol. 28 (22): 212-215 [Abstract] ( 39 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
216 Investigation on the Service Capacity of Community Vaccination Clinic in Chongming District,Shanghai
LU Jian； ZHAO Jie； CHEN Ming-hao
Objective To understand the current situation of community vaccination clinics in Chongming District,Shanghai,and to provide scientific basis for further rational establishment of vaccination clinics.Methods The descriptive epidemiological method was used to analyze the basic setup of community vaccination clinic,staff configuration,service situation,cold chain equipment and parents′ satisfaction with vaccination in Chongming District,Shanghai from January to December 2019.Results A total of 94.44% of the outpatient clinics have reached the standard of the city′s standardized outpatient clinics,and 94.44% of the vaccination outpatient clinics frequency was 2 days or more per week.Among the vaccination staff,full-time staff account for 14.48%,and the most studied professional nursing accounts for 55.86%.The number of years engaged in immunization planning was mainly ≤5 years,accounting for 78.62%,and the professional title was mainly primary,accounting for 60.69%.The average daily dose of outpatient vaccination is 67 doses; medical refrigerators mainly used in outpatient refrigerators account for 75%; parents of children very satisfied with the overall evaluation of vaccination account for 98.74%.Conclusion The community vaccination outpatient clinics in Chongming District of Shanghai can meet the needs of vaccination service in the district,but the service capacity is not strong.In the future,we should further speed up the warm and digitalizd construction of outpatient clinics and strengthen the training of talents.
2021 Vol. 28 (22): 216-219 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
220 Study on tobacco prevalence and its influencing factors among permanent residents in Zhaoqing City
TAN Jin-quan； CHEN Si；ZENG Huo-lan
Objective To understand the prevalence of tobacco among permanent residents in Zhaoqing City and its influencing factors,and to discuss the direction and strategies of tobacco control work in the future.Methods A total of 3861 permanent residents aged 15-69 years old in Zhaoqing City were selected from July to November 2019,and 3845 questionnaires were effectively answered.The smoking rate and daily smoking rate of residents were investigated,and the influencing factors of smoking behavior were studied with relevant statistical methods.Results The smoking rate of permanent residents in Zhaoqing City was 30.33%,among which males were 54.66% and females were 1.59%.The daily smoking rate was 26.45%,48.27% for males and 0.68% for females.The second-hand smoking exposure rate of smokers was 87.31%,and that of non-smokers was 42.07%.The awareness rate of lung cancer,the most common disease caused by tobacco,in smokers and non-smokers was 67.15% and 92.09% respectively.The awareness rate of apoplexy in smokers and non-smokers was 47.51% and 71.37% respectively.The awareness rate of heart disease in smokers and non-smokers was 43.48% and 65.32% respectively.Non-smokers had better knowledge of tobacco hazards,and non-smokers also had higher knowledge of second-hand smoking hazards(P<0.05).Smoking behavior varied by gender,age,education,occupation,annual household income and health literacy level(P<0.05).The multi-factor results showed that smoking was closely related to three factors: gender,age,and health literacy level(P<0.05).Conclusion The smoking rate of permanent residents aged 15-69 years old in Zhaoqing City is relatively high.The publicity and education of tobacco control should be continued to strengthen,and the construction of smoking cessation outpatient service and the service efficiency should be actively improved,so as to continuously improve the health literacy level of residents and reduce the harm of tobacco to human body.
2021 Vol. 28 (22): 220-224 [Abstract] ( 43 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
225 Study on obesity status and cognition of obesity-related glomerulopathy in community residents in northeast Sichuan
LIU Jia-li；LIN Ling； XIE Rong
Objective To investigate the obesity status of community residents in northeast Sichuan and their cognition of obesity-related glomerulopathy(ORG),and to analyze the related influencing factors.Methods According to the random sampling method,1905 residents were randomly selected from 5 regions in northeastern Sichuan from July 2018 to September 2018 as the survey subjects.Questionnaires were used to conduct the survey,which included basic information,health knowledge and examination,and ORG related knowledge.Results The obesity rate of residents in northeastern Sichuan was 11.8%,the overweight rate was 35.9%,and the residents′ awareness of ORG was 13.4%.The results of univariate analysis showed that the education level,age and whether to go for a physical examination were the influencing factors of residents′ awareness of ORG,and the differences were statistically significant(P<0.05).The results of multivariate analysis showed that educational level,age and whether to go for a physical examination were factors influencing the recognition of inhabitant ORG,and the differences were statistically significant(P<0.05).Conclusion The residents in northeast Sichuan have relatively high rates of overweight and obesity,and their awareness of ORG is low.Health education and publicity should be strengthened to improve residents′ self-health management awareness and increase the public′s awareness rate of ORG.
2021 Vol. 28 (22): 225-228 [Abstract] ( 41 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
229 Application of neuronavigation technology in anatomy teaching of neurosurgery
HAN Zhi-tong；ZHANG Rui-jian
Objective To explore the application effect of neuronavigation technology in anatomy teaching of neurosurgery.Methods A total of 50 neurosurgeons in the Department of Neurosurgery of the People′s Hospital of Inner Mongolia Autonomous Region from January 2016 to January 2020 were selected as the observation objects.According to the random number table method,they were divided into the observation group(25 cases)and the control group(25 cases).In the control group,the routine teaching method was used,the observation group adopted neuronavigation technique combined teaching method,the results of the two groups were compared.Results The score of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05）.Conclusion Neuronavigation technology in clinical practice can not be ignored,clinicians should learn to correctly apply the technology,accurately understand,skilled operation,with the help of neuronavigation technology teaching to improve the quality of personnel training,popularize neuronavigation technology,play the important advantages of neuronavigation technology in neurosurgery clinical.
2021 Vol. 28 (22): 229-231 [Abstract] ( 49 ) HTML (30 KB)  PDF  (0 KB)  ( 7 )
232 Application of case method in the teaching of Internal Medicine of Traditional Chinese Medicine
CHEN Yu-yu； GUO Yan-fen； ZHAO Zhong-wen；WU Fang-zhen
As the main subject of traditional Chinese medicine(TCM)clinic,the reform and development of Internal Medicine of Traditional Chinese Medicine plays an important role in promoting the development of TCM teaching.Case-based learning(CBL）can increase students′ learning interest and enthusiasm,and help to develop students′clinical thinking ability and comprehensive ability.This article makes a preliminary exploration on the application of CBL in the teaching of internal medicine of traditional Chinese medicine,and provides reference for the later teaching.This article discusses the necessity,advantages,implementation,evaluation,significance and points for attention of the CBL.CBL is a teaching method suitable for TCM internal medicine,which is conducive to the training of qualified TCM doctors and can be popularized in future teaching.
2021 Vol. 28 (22): 232-234 [Abstract] ( 31 ) HTML (32 KB)  PDF  (0 KB)  ( 5 )
235 Application of PBL combined with MDT teaching mode in pediatric residents standardized training
WU Ze-lin； WEI Feng-gui； LIANG Ming； GUAN Jing-ming； ZHONG Guo-yu； ZOU Ya-wei ；CHEN De-hui
Objective To develop the application of problem-based learning(PBL)combined with multidisciplinary team(MDT)model in pediatric clinical teaching,and to evaluate its influence on the comprehensive clinical abilities including clinical thinking of junior resident pediatrician.Methods From July 2017 to July 2020,a total of 40 residents(including the standardized training of general practitioners and professional masters)who received the standardized training of residents in department of Pediatrics,the First Affiliated Hospital of Guangzhou Medical University were selected as the research objects,they were divided into the experimental group and the control group according to the random number table method,with 20 residents in each group.The experimental group was given PBL combined with MDT teaching,and the control group was given traditional teaching.The stage test score and the questionnaire results were compared between the two groups.Results The scores of the theory test,test passing rate and excellent rate of the experimental group were higher than those of the control group,the differences were statistically significant(P<0.05).The satisfaction of the teaching method in the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).Over 85% of the standardized training residents in the experimental group considered that the teaching mode of the PBL combined with MDT had certain advantages to improve the learning initiative and enthusiasm,improving clinical thinking and problem-solving ability.Conclusion The teaching mode of the PBL combined with MDT is beneficial to cultivate the clinical thinking of pediatricians and improve their clinical comprehensive ability.It is worth popularizing in clinical teaching．
2021 Vol. 28 (22): 235-238 [Abstract] ( 39 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )
239 Understanding and application of the connection view of the materialist dialectics respiratory physiology in respiratory physiology and the infection of respiratory virus
PAN Yuan； YAN Zhi
The composition of respiratory system and the cooperation between respiratory system and surrounding muscle tissues both embody the principle of connection view of materialist dialectics.The infection symptoms link closely to the type of respiratory virus.Furthermore,the corresponding therapies conducted for people contracted with specific respiratory viruses may vary accordingly.This also highlights the diversity of connections.
2021 Vol. 28 (22): 239-241 [Abstract] ( 26 ) HTML (27 KB)  PDF  (0 KB)  ( 7 )
242 Application of continuous nursing intervention of medical care integration in management of stable chronic obstructive pulmonary disease
LIAO Cui-hong；LIU Ling；TANG Xiao-yuan；LIU Hua-zhi
Objective To explore the application effect of continuous nursing intervention based on the integration of medical and nursing in the management of patients with stable chronic obstructive pulmonary disease(COPD）.Methods A total of 66 patients with stable COPD in the First Affiliated Hospital of Gannan Medical University from October to December 2018 were selected as subjects of study and divided into the experimental group and the control group according to random number table method,33 cases in each group.The control group was given routine discharge education mode,and the experimental group was given continuous nursing intervention mode of medical and nursing integration on this basis.The patients were followed up for 6 months.Self-management ability,COPD disease assessment test(CAT）score and 6-minute walk test(6MWD)were compared between two groups.Results The scores of self-management ability,CAT and 6MWT in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion The continuous nursing intervention of medical and nursing integration in the management of patients with stable COPD can effectively improve the self-care ability of patients,improve the lung function of patients,reduce symptoms,and improve the quality of life,which is worthy of further promotion and application of clinical nursing.
2021 Vol. 28 (22): 242-245 [Abstract] ( 39 ) HTML (39 KB)  PDF  (0 KB)  ( 7 )
246 Effects of sports rehabilitation nursing combined with home self-care on self-care ability and quality of life of elderly patients with chronic heart failure
YU Yue-hui ；WANG Xiao-xin ；ZHAO Jing-shu； LI Lu； ZHAO Hong-li
Objective To explore the effect of sports rehabilitation nursing combined with home self-care on self-care ability and quality of life in elderly patients with chronic heart failure.Methods A total of 200 elderly patients with chronic heart failure admitted to the Second Affiliated Hospital of Shenyang Medical College from September 2018 to May 2020 were selected and divided into the control group(100 cases)and the observation group(100 cases)according to random number table method,the control group was given routine nursing,and the observation group was given exercise rehabilitation nursing combined with home self-nursing.The self-care ability,quality of life and cardiac function were compared between the two groups.Results Before nursing,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)between two groups were compared，the differences had no statistical significance(P＞0.05); after nursing,LVEDD,LVESD in two groups were lower than before nursing,the LVEF in two groups were higher than before nursing,LVEF,LVEDD of the observation group were higher than those in the control group,LVESD of the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).Before nursing,the scores of nursing competency scale(ESCA)and quality of life scale(SF-36)in the two groups were compared,the differences had no statistical significance(P＞0.05);after nursing,the scores of ESCA and SF-36 in the two groups were higher than before nursing,the scores of ESCA and SF-36 in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Exercise rehabilitation nursing combined with home self-care has a good effect on improving the self-care ability and quality of life of patients with the disease.
2021 Vol. 28 (22): 246-248转252 [Abstract] ( 37 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
249 Application effect of online STAMP scale in the application of screening of risk of malnutrition in children
ZENG Li； TANG Wei ；GUO Jie
Objective To explore application effect of online screening tool for the assessment of malnutrition in paediatrics(STAMP)scale in the screening of risk of malnutrition in children.Methods The clinical data of 200 children who accepted online screening toolforthe assessment of malnutritionin pediatrics （STAMP） scale to assess the risk of malnutrition and hospitalized in Pingxiang People′s Hospital in Jiangxi Province from October 2018 to October 2019 were retrospectively analyzed and included in the observation group,in addition,the clinical data of 200 hospitalized children with routine nursing intervention in Pingxiang People′s Hospital in Jiangxi Province during the same period were collected and included in the control group.The nursing compliance,parents′ mastery of health knowledge and parents′ nursing satisfaction were compared in the two groups.Results The total excellent and good rate of compliance of children in the observation group(83.00%)was higher than that in the control group(50.50%),with statistical difference(P＜0.05）.After the end of intervention,the mastery of health knowledge of parents of children in the observation group(93.50%)was better than that in the control group(32.00%),with statistical difference(P＜0.05).The parents′nursing satisfaction of children in the observation group(91.50%)was higher than that in the control group(53.50%),with statistical difference(P＜0.05）.Conclusion Online STAMP scale was used to screen the risk of malnutrition in hospitalized children,and corresponding nutritional intervention was given,which is helpful to improve the mastery of health knowledge of parents,and the nursing satisfaction is relatively high,can provide an important reference for quickly investigating the malnutrition risk of hospitalized children and improving the nursing effect of children′s nutrition and health care.
2021 Vol. 28 (22): 249-252 [Abstract] ( 33 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
253 Application effect of evidence-based nursing in patients with nasopharyngeal carcinoma PICC simultaneous radiotherapy and chemotherapy
CHEN Yu-lan； ZHANG Jie-ling； HUANG Fen
Objective Discuss the application effect of evidence-based nursing in patients with nasopharyngeal carcinoma（PICC）radiotherapy and chemotherapy.Methods From October 2019 to October 2020,100 patients with synchronous radiotherapy and chemotherapy of nasopharyngeal carcinoma PICC catheterization admitted to the Second Affiliated Hospital of Nanchang University were selected as the research subjects.It was divided into the control group(50 cases)and the observation group(50 cases)follow the double-blind method.The control group was treated with routine nursing assistance,the observation group used evidence-based nursing intervention at the same time as routine nursing,self-rating depression scale(SDS)and self-rating anxiety scale(SAS)scores,quality of life scores,and incidence of complications were compared between the two groups.Results There were no significant of SDS,SAS and quality of life scores before nursing in the two groups(P＞0.05).Two groups of the SDS and SAS scores after nursing were lower than before nursing,and the quality of life score was higher than before nursing,the differences were statistically significant(P<0.05),the SDS and SAS scores in observation group after nursing were lower than those in control group,and the quality of life score was higher than that in control group,the differences were statistically significant(P<0.05).Total incidence of complication in the observation group was 12.00%,lower than that in the control group(32.00%),the difference was statistically significant(P<0.05).Conclusion During the treatment of nasopharyngeal carcinoma patients with synchronous radiotherapy PICC chemotherapy and catheterization,the value of anxiety and depression decreased,the quality of life improved obviously,and the probability of complications decreased,which is worthy of clinical application.
2021 Vol. 28 (22): 253-255 [Abstract] ( 33 ) HTML (30 KB)  PDF  (0 KB)  ( 8 )
256 Application of cluster nursing combined with respiratory training in patients with dysphagia after stroke
ZOU Jing； YU Qing； XU Ling-feng
Objective To explore the effect of cluster nursing combined with breathing training on patients with dysphagia after stroke.Methods A total of 60 patients with dysphagia after stroke admitted to Jiujiang First People′s Hospital from January 2019 to October 2020 were selected as the research objects and divided into the control group(n=30)and the experimental group(n=30)according to random number table method.On the basis of acupuncture treatment,the control group was given routine nursing,while the experimental group was given cluster nursing and respiratory training.The swallowing function,quality of life and nursing satisfaction of two groups were compared.Results Before the intervention,there was no significant difference in Kubota water swallow test and Fujishima Ichiro rating sccale score between the two groups(P＞0.05); after intervention,Kubota water swallow test and Fujishima Ichiro rating sccale score of the experimental group was lower than that of the control group,the difference was statistically significant(P<0.05).After intervention,the score of quality of life in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).After intervention,the nursing total satisfaction of the experimental group was 93.33%,which was higher than 73.33% of the control group,the difference was statistically significant(P<0.05).Conclusion Cluster nursing combined with breathing training methods to intervene patients with swallowing dysfunction after stroke can achieve better nursing results,effectively improve the swallowing function of patients,improve the quality of life,and increase nursing satisfaction.
2021 Vol. 28 (22): 256-259 [Abstract] ( 38 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
260 Application of comprehensive nursing mode in the treatment of diabetic macular edema by intravitreal injection of Ranibizumab combined with argon laser
QIU Yuan-yuan； LI Sheng； DU Ying
Objective To explore the application of comprehensive nursing model in intravitreal injection of Ranibizumab(IVR)combined with argon laser in the treatment of diabetic macular edema(DME).Methods Sixty-four patients with DME who underwent IVR combined with argon laser treatment,who were admitted to Dalian Third People′s Hospital from January to December 2019 were selected as the research objects.They were divided into the reference group(32 cases)and the study group(32 cases)according to the random envelope method.Example,the reference group adopts conventional nursing,and the study group adopts comprehensive nursing.The eye examination indicators,complication rate,and nursing satisfaction scores of the two groups were compared.Results FOVEA thickness of macula(CRT)after nursing in the study group was lower than that of the reference group,best corrected vision(BCVA)was higher than that of the reference group,and the nursing satisfaction score was higher than that of the reference group,the differences were statistically significant(P＜0.05）; the total complication rate of the study group(2.33%)was lower than that in the reference group(16.29%),the difference was statistically significant(P＜0.05）.Conclusion During the treatment of DME with IVR combined with argon laser,comprehensive care of patients can improve eye indicators,increase satisfaction,and reduce complications.It is recommended to promote the use.
2021 Vol. 28 (22): 260-262转266 [Abstract] ( 30 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
263 Effect of preventive nursing in operating room on postoperative incision infection in patients with open fracture of limbs
LONG Yan-hong
Objective To investigate the effect of preventive care in the operating room on postoperative wound infection in patients with open limb fractures.Methods Sixty patients with open limb fractures admitted to Fuzhou First People′s Hospital from May 2018 to October 2020 were selected as the research objects,and were divided into the control group(30 cases)and the observation group(30 cases)according to the random touch method .The control group received routine care,and the observation group used preventive care in the operating room.The two groups′ wound healing goodness,incidence of postoperative wound infection,nursing acceptance,self-care ability and quality of life were compared between the two groups.Results Comparing the two groups,the goodness of wound healing in the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05）; the incidence of postoperative wound infection in the observation group was lower than that of the control group,and the difference was statistically significant(P＜0.05）.The nursing recognition of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05）; the self-care ability and quality of life of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05）.Comparing the same group before and after treatment,the scores of self-care ability and quality of life of the two groups after treatment were higher than those before treatment,the differences were statistically significant(P<0.05）.Conclusion Providing preventive care in the operating room for patients with open limb fractures can effectively prevent postoperative wound infection,accelerate wound healing,improve the quality of life of patients,and gain high recognition from patients.
2021 Vol. 28 (22): 263-266 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
267 Influence of continuous nursing intervention on the functional recovery and prognosis of the hip joint in patients undergoing total hip arthroplasty
XIAO Li-ping
Objective To explore the effect of continuous nursing intervention on hip function recovery and prognosis of patients undergoing total hip arthroplasty(THR).Methods A total of 76 patients who underwent THR from January 2018 to March 2020 in Jinggangshan Traditional Chinese Medicine Hospital in Jiangxi Province were selected.They were divided into the observation group(38 cases)and the control group(38 cases)according to the random number table method.The control group was given routine nursing,and the observation group was applied with continuous nursing intervention.The hip joint function,quality of life,and complications were compared between the two groups before and after the intervention.Results Before the intervention,there were no statistically significant differences in hip function scores or quality of life scores between the two groups(P＞0.05).After the intervention,the hip function and quality of life scores between the two groups were higher than those before the intervention the hip joint function score was(76.57±8.32)points and the quality of life score was(79.75±7.29)points in the observation group after the intervention,higher than those in the control group of(60.53±7.48)and(66.25±7.98)points,respectively,the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was 5.26%,lower than that in the control group accounting for 23.68%,the difference was statistically significant(P<0.05).Conclusion Continuous nursing intervention can promote the recovery of hip joint function,improve the quality of life,and reduce the occurrence of complications in patients undergoing THR.
2021 Vol. 28 (22): 267-269 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
270 Effect of cognitive behavioral intervention on psychological status and treatment compliance of patients with bladder tumor after chemotherapy
LI Jie-qiong； FENG Kun-xian； LIN Wan-xun
Objective To explore the effect of cognitive behavioral intervention on the psychological status and treatment compliance of patients with bladder tumor after chemotherapy.Methods From June 2019 to June 2020,120 patients with bladder tumor who met the inclusion criteria treated in Jiangmen People′s Hospital in Guangdong Province were selected as research subjects and divided into the study group(n=60)and the reference group(n=60)by drawing lots.The reference group was given routine nursing intervention,while the study group was given cognitive behavior intervention on the basis of the reference group.The psychological state changes of the two groups before and after the intervention was evaluated by self rating anxiety scale(SAS)and self rating depression scale(SDS)and the treatment compliance and nursing satisfaction of the two groups were compared.Results There were no significant differences in SAS and SDS scores between the two groups before the intervention(P＞0.05).The SAS and SDS scores of the two groups after the intervention were lower than those before the intervention,and the SAS and SDS scores of the study group were lower than those of the reference group,the differences were statistically significant(P<0.05).The total compliance of the study group was 91.67%,which was higher than 78.33% of the reference group,the nursing total satisfaction of the study group was 93.33%,which was higher than 75.00% of the reference group,the differences were statistically significant(P<0.05).Conclusion The implementation of cognitive behavior intervention can improve the psychological state of patients with bladder cancer after bladder perfusion chemotherapy,help to improve the treatment compliance of patients,and also improve the nursing satisfaction of patients.
2021 Vol. 28 (22): 270-272转276 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
273 Impact of continuing nursing combined with multimedia health education on elderly patients with chronic diseases
WU Xue-ying； ZHANG Hong
Objective To explore the impact of continuing nursing combined with multimedia health education on elderly patients with chronic diseases.Methods A total of 80 elderly patients with chronic diseases admitted to the Affiliated Hospital of Fujian Health Vocational and Technical College from January to October 2020 were selected as the research subjects.According to the random number table,they were divided into the control group and the observation group,40 cases in each group.The control group provided with conventional nursing measures and health education model,the observation group adopted continuing nursing combined with multimedia health education.The self-care ability,health behavior cognition,and nursing satisfaction between the two groups were compared.Results The self-care ability score of the observation group was higher than that of the control group,the health behavior cognitive score of the observation group was higher than that of the control group,and the differences were statistically significant(P＜0.05）.The nursing satisfaction rate was 92.50%,higher than that of the control group accounting for 72.50%,and the difference was statistically significant(P＜0.05）.Conclusion The combined application of continuing nursing and multimedia health education during the nursing of elderly patients with chronic diseases can improve patients′cognitive function,enhance their self-care ability and medication compliance,and play a positive role in ameliorating the quality of life.
2021 Vol. 28 (22): 273-276 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
Copyright © Editorial Board of 中国当代医药
Supported by:Beijing Magtech