地佐辛联合舒芬太尼对剖宫产后镇痛效果及产后抑郁的影响

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Abstract Objective To investigate the influence on Dezocine combined with Sufentanil on postpartum analgesia effect and postpartum depression after cesarean section.Methods A total of 120 parturients who underwent cesarean section in the Maternal and Child Health Care Hospital of Longgang District in Shenzhen City from July 2019 to June 2020 were selected.According to the double-blind randomized trial design,they were divided into observation group and control group,with 60 parturients in each group.After the operation,both groups of patients used analgesic pumps.The observation group used Dezocine combined with Sufentanil for analgesia,and the control group only used Sufentanil for analgesia.The visual analogue scale(VAS)and Ramsay sedation score were used to evaluate postoperative analgesia and sedation in the two groups.The incidence of adverse reactions in the two groups was statistically analyzed.Edinburgh postnatal depression scale(EPDS)was used to evaluate the scores of maternal depression in the two groups.Results The VAS pain score at 24 h after surgery in the observation group was higher than that at 12 h after surgery,and the difference was statistically significant(P<0.05).There was no significant difference between the VAS pain scores at 36 h after surgery and 12 h after surgery in the observation group(P>0.05).The VAS pain score at 36 h after surgery was lower than that at 12 h after surgery in the control group,and the difference was statistically significant(P<0.05).There was no significant difference between the VAS pain scores at 24 h after surgery and 12 h after surgery in the control group(P>0.05).The VAS pain scores of the observation group at 12,24 and 36 h after surgery were lower than those of the control group,with statistically significant differences(P<0.05).At 24 and 36 h after surgery,Ramsay sedation scores of the two groups were lower than those of 12 h after surgery,the differences were statistically significant(P<0.05).Ramsay sedation scores of observation group at 12,24 and 36 h after surgery were higher than those of control group,with statistically significant differences(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The EPDS scores of observation group at 4 and 6 weeks postpartum were higher than those at 2 weeks postpartum,and the differences were statistically significant(P<0.05).There were no significant differences in EPDS scores between the control group at 4,6 weeks postpartum and 2 weeks postpartum(P>0.05).EPDS scores of the observation group were lower than those of the control group at 2 and 4 weeks postpartum,the differences were statistically significant(P<0.05).At 6 weeks postpartum,there was no significant difference in EPDS scores between the two groups(P>0.05).Conclusion Dezocine combined with Sufentanil has a strong analgesic and sedative effect.There is no need to increase the dose for analgesia after surgery,and it will not be excessively sedated.At the same time,the combination of Dezocine and Sufentanil may reduce the incidence of postpartum depression in the short term.

Key words： Dezocine Sufentanil Cesarean section Postpartum depression Postoperative analgesia

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	YU Hong-tian
	LI Yi-ling
	PENG Li-yun

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YU Hong-tian,LI Yi-ling,PENG Li-yun. Influence on Dezocine combined with Sufentanil on postpartum analgesia effect and postpartum depression after cesarean section[J]. 中国当代医药, 2021, 28(22): 170-173.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I22/170

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