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| Clinical effect of Benazepril combined with L-carnitine in the treatment of patients with heart failure |
| TAN Tian-xing |
| Department of Cardiology,the Second People′s Hospital of Baiyun District,Guangdong Province,Guangzhou 510450,China |
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Abstract Objective To investigate the clinical effect of Benazepril combined with L-carnitine in the treatment of patients with heart failure.Methods A total of 68 patients with heart failure who were addmited in the Second People′s Hospital of Baiyun District from August 2019 to August 2020 were selected as subjects.They were divided into the control group and the study group by random number table,with 34 cases in each group.The control group was treated with Benazepril,and the study group was treated with L-carnitine+Benazepril.Cardiac function indexes(left ventricular end-diastolic volume[LVEDV],left ventricular ejection fraction[LVEF]and cardiac output[CO]),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),plasma N-terminal brain natriuretic peptide precursor(NT-proBNP)levels and walking distance within 6 minutes before and after treatment were compared between the two groups.Results After treatment,the LVEDV level of the study group was lower than that of the control group,and the levels of LVEF and CO were higher than those of the control group,and the differences were statistically significant(P<0.05).In the study group,the walking distance within 6 min after 8 and 16 days of treatment was longer than that in the control group,and the difference was statistically significant(P<0.05).The levels of NT-proBNP,IL-6,and TNF-α in the study group were lower than those in the control group after treatment,and the differences were statistically significant(P<0.05).Conclusion The application of L-carnitine+Benazepril for heart failure has a better effect,which can improve the patient′s heart function,increase exercise endurance,reduce the inflammatory response in the body,and improve the treatment effect.
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