|
|
|
| Effect of Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction and its influence on high sensitivity Creactive protein |
| DONG Dan HAN Lin-shan |
| Department of Pharmacy,Central Hospital Affiliated to Shenyang Medical College,Liaoning Province,Shenyang 110024,China. |
|
|
|
|
Abstract Objective To investigate the effect of Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction and its influence on the level of hypersensitive C-reactive protein(hs-CRP).Methods Ninety-two patients with acute myocardial infarction admitted to the Central Hospital Affiliated to Shenyang Medical College from March 2017 to July 2018 were selected as the research subjects,and they were divided into observation group and control group according to random number table method,with 46 patients in each group.The two groups were treated with intravenous pumping Urokinase 30 minutes after admission,the control group was treated with Aspirin,and the observation group was combined with Clopidogrel on the basis of the control group.After treatment,the patients were followed up for 3 months.The blood coagulation function,hs-CRP levels and the incidence of cardiovascular events in the two groups were compared.Results The prothrombin time(PT)and activated partial thromboplastin time(APTT)of the observation group at 1 month after treatment were longer than those of the control group,and the fibrinogen(FIB)level was lower than that of the control group(P<0.05); the hs-CRP levels of the observation group at 1,2 and 3 months after treatment were lower than those of the control group(P<0.05); the incidence rates of myocardial infarction,angina pectoris,heart failure,arrhythmia and mortality in the observation group were lower than those in the control group(P<0.05).Conclusion Aspirin combined with Clopidogrel in the treatment of patients with acute myocardial infarction can significantly improve the coagulation function,significantly reduce the level of hs-CRP,and reduce the risk of cardiovascular events,which is worthy of popularization and application.
|
|
|
|
|
|
| [1] |
张红.阿司匹林与氯吡格雷联合治疗急性心肌梗死患者的凝血功能变化[J].血栓与止血学，2016，22（6）：641-643.
|
| [2] |
陈洪云，刘玲，吴猛，等.参附注射液联合阿司匹林与氯吡格雷和低分子肝素治疗急性心肌梗死的急救体会[J].中国中西医结合急救杂志，2016，23（4）：431-432.
|
| [3] |
Wang Y，Minematsu K，Wong KS，et al.Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients：From the SOCRATES Trial Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes）[J].Stroke，2017，48（1）：167-173.
|
| [4] |
郭仕俊，苏令，章福彬，等.氯吡格雷联合肠溶性阿司匹林在急性心肌梗死治疗中的应用[J].蚌埠医学院学报，2017，42（4）：458-461.
|
| [5] |
赵向辉.氯吡格雷、阿司匹林合并应用于急性心肌梗死临床治疗的血管再通率分析[J].中国医药导刊，2017，19（1）：71-72.
|
| [6] |
金洪珍，张盼.氯吡格雷联合阿司匹林治疗急性心肌梗死的临床疗效观察[J].山西医药杂志，2017，46（21）：2629-2631.
|
| [7] |
Edfors R，Sahlén A，Szummer K，et al.Outcomes in patients treated with ticagrelor versus clopidogrel after acute myocardial infarction stratified by renal function[J].Heart，2018，104（19）：1575-1582.
|
| [8] |
唐静宜，刘剑敏，张耕.CYP2C19 和阿司匹林药物基因分型指导PCI 术后急性心肌梗死1 例[J].中国医药导报，2016，13（29）：175-177.
|
| [9] |
李坤，罗芳，黄素素，等.双联抗血小板联合质子泵抑制剂治疗急性心肌梗死对患者预后的影响[J].海南医学，2017，28（22）：3637-3639.
|
| [10] |
王小东，庄少伟，张旭敏，等.替格瑞洛对老年急性心肌梗死患者血小板功能及临床预后的影响[J].国际心血管病杂志，2016，43（3）：183-186.
|
| [11] |
申文宇.替格瑞洛改善氯吡格雷抵抗急性心肌梗死患者治疗的疗效分析[J].中国现代医学杂志，2017，27（14）：115-118.
|
| [12] |
Sahlén A，Varenhorst C，Lagerqvist B，et al.Outcomes in patients treated with ticagrelor or clopidogrel after acute myocardial infarction：experiences from SWEDEHEART registry[J].Eur Heart J，2016，37（44）：3335-3342.
|
| [13] |
孙晋亮，孙建辉，柯海燕，等.比伐卢定联合替罗非班和替格瑞洛用于急性心肌梗死急诊PCI 的疗效和安全性研究[J].中西医结合心脑血管病杂志，2016，14（8）：904-906.
|
| [14] |
张卉，付长丛.氯吡格雷对急性心肌梗死合并心力衰竭患者血清炎性因子及超声心动图指标的影响[J].河北医药，2016，38（16）：2447-2449.
|
| [15] |
吴德旭，朱君，蔡文渊，等.丹参多酚酸盐对急性心梗PCI术患者氧化应激与血管内皮功能的影响[J].实用临床医药杂志，2016，20（19）：16-19.
|
|
|
|
