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2021 Vol. 28, No. 33 Published: 2021-11-28

	4	Acute proarrhythmic effect of low dose of bisphenol A on female adult rat and the electrophysiologic mechanisms
		YAN Su-juan；CHENG Xiao-shu；HONG Kui；LI Ju-xiang； CHEN Ya-mei；SONG Wei-zhong；DONG Min； WANG Hong-sheng
		Objective To investigate the female specific acute proarrhythmic effect of low dose of bisphenol A(BPA)on adult rat and the electrophysiologic mechanisms.Methods The isolated ventricular myocytes were divided into normal control group,BPA group(10-9mol/L,2×10-9mol/L),estradiol(E2)group(10-9mol/L,2×10-9mol/L)and BPA+E2group.The isolated heart experiment was divided into normal control group,BPA+E2group,norepinephrine (ISO)group and BPA+E2+ISO group.The electrocardiogram of the isolated heart was recorded by PowerLab 4/30 immediately after confocal fluorescence microscopy.Results The cell shrinkage rates of female rat cardiomyocytes in BPA and E2groups were higher than that in normal control group,and that in BPA+E2group was higher than that in normal control group,BPA group and E2group,and the differences were statistically significant(P＜0.01).There was no statistically significant difference in cell shrinkage rate between BPA and E2groups and normal control group (P＞0.05).The transient percentage of ventricular myocytes in BPA group and 2×10-9mol/L BPA group were higher than that in normal control group,and the differences were statistically significant(P＜0.01).The transient percentage of ventricular myocytes in E2 group was higher than that in normal control group,and the difference was statistically significant(P＜0.05).The transient percentage of ventricular myocytes in 2×10-9mol/L E2group was higher than that in normal control group,and the difference was statistically significant(P＜0.01).The transient percentage of ventricular myocytes in BPA+E2 group was higher than that in normal control group,BPA group and E2group,and the differences were statistically significant(P＜0.05).The in vitro ventricular premature frequency of ISO+BPA+E2group was higher than that of normal control group,BPA+E2group and ISO group,and the differences were statistically significant(P＜0.05).Conclusion Low doses of BPA in acute phase can induce cardiac arrhythmias by inducing delayed after depolarization(DAD)generation in rat ventricular myocytes.This effect is sex-specific in females,and there is a synergistic effect between low doses of BPA and physiological concentration of E2.
		2021 Vol. 28 (33): 4-7转16 [Abstract] ( 46 ) HTML (45 KB) PDF (0 KB) ( 8 )

	8	Study on the mechanism of Liqi Buxue Decoction in delaying denervated skeletal muscle atrophy by regulating TGF-β1/Smad pathway
		ZHAO Chang-yun-lei；LIU Jun-ning；ZHAO Yu；GUO Shuang；LI Nan；NIU Su-sheng；ZHANG Yan
		Objective To explore the effect and mechanism of Liqi Buxue Decoction on denervated skeletal muscle atrophy.Methods A total of 54 SD rats were randomly divided into the sham operation group (n=18),the model group(n=18)and the Liqi Buxue Decoction group (n=18).The gastrocnemius muscle atrophy model was made by cutting off the right tibial nerve.The wet weight ratio of gastrocnemius muscle was measured after 7,28 56 days,the cross-sectional area and diameter of muscle fibers and the volume of collagen fibers were measured by HE staining and Masson staining,the expression of TGF-β1,Smad2,Smad3,MyoD1 and MuRF1 mRNA in gastrocnemius muscle was detected by quantitative real-time PCR,and the expression of myosin was detected by immunofluorescence.Results After 7,28,56 days of the intervention,frum muscle wet weight ratio of the model group and the Liqi Buxue Decoction group was lower than that of the sham operation group in the same period,the difference was statistically significant(P＜0.05).After 7,28,56 days of the intervention,frum muscle wet weight ratio of the the Liqi Buxue Decoction group was higher than that of the model group in the same period,the difference was statistically significant(P＜0.05).After 7,28,56 days of the intervention,muscle fiber cross-sectional area and diameter of the model group and the Liqi Buxue Decoction group were lower than those of the sham operation group in the same period,the differences were statistically significant(P＜0.05).After 7,28,56 days of the intervention,muscle fiber cross-sectional area and diameter of the Liqi Buxue Decoction group were higher than those of the model group in the same period,the differences were statistically significant(P＜0.05).After 7,28,56 days of the intervention,collagen volume fraction of the gastrocnemius muscle of the model group and the Liqi Buxue Decoction group was lower than that of the sham operation group in the same period,the difference was statistically significant(P＜0.05).After 7,28,56 days of the intervention,collagen volume fraction of the gastrocnemius muscle of the Liqi Buxue Decoction group was lower than that of the model group in the same period,the difference was statistically significant(P＜0.05).After 7 days of the intervention,there was no statistically significant difference of Smad2 expression between the Liqi Buxue Decoction group and the sham operation group (P＞0.05).After 7,28,56 days of the intervention,the expression of TGF-β1,Smad2,Smad3,MyoD1 mRNA of the model group and the Liqi Buxue Decoction group were higher than those of the sham operation group in the same period,the differences were statistically significant(P＜0.05).After 7,28,56 days of the intervention,the expression of TGF-β1,Smad2,Smad3 mRNA were lower than those of the model group in the same period,the differences were statistically significant(P＜0.05).After 7,28,56 days of the intervention,the expression of MyoD1 mRNA of the Liqi Buxue Decoction group was higher than that of the model group in the same period,the difference was statistically significant(P＜0.05).After 7,28,56 days of the intervention,the expression of MURF1 mRNA of the model group and the Liqi Buxue Decoction group was higher than that of the sham operation group in the same period,the difference was statistically significant(P＜0.05).After 7,28,56 days of the intervention,the expression of MURF1 mRNA of the Liqi Buxue Decoction group was lower than that of the model group in the same period,the difference was statistically significant(P＜0.05).After 7,28,56 days of the intervention,the expression of phocnemius myosin of the model group and the Liqi Buxue Decoction group was lower than that of the sham operation group in the same period,the difference was statistically significant(P＜0.05).After 7,28,56 days of the intervention,the expression of phocnemius myosin of the Liqi Buxue Decoction group was lower than that of the model group in the same period,the difference was statistically significant(P＜0.05).Conclusion Liqi Buxue Decoction can delay denervated skeletal muscle atrophy in rats,which is related to regulating TGF-β1/Smad signal pathway,reducing skeletal muscle protein degradation and inhibiting skeletal muscle fibrosis.
		2021 Vol. 28 (33): 8-16 [Abstract] ( 42 ) HTML (66 KB) PDF (0 KB) ( 6 )

	17	Application effect of Etomidate combined with Sufentanil in painless gastroscopy in elderly patients with coronary heart disease
		WU Xiong-feng；HUANG Hui；ZHANG Jin-ju
		Objective To explore the application effect of Etomidate combined with Sufentanil in painless gastroscopy in elderly patients with coronary heart disease.Methods From January 2019 to June 2020,a total of 80 elderly patients with coronary heart disease undergoing painless gastroscopy who were admitted to the Fifth Hospital of Nanchang were selected as the research objects,and were divided into control groups(40 cases)and observation group (40 cases)according to the random number table method.The control group was given Sufentanil combined with Propofol,and the observation group was given Sufentanil combined with Etomidate.The myocardial enzyme indexes when leaving the gastroscope room,eye opening time,active response time,time to leave the gastroscope room,hemodynamic indexes during the peri-anaesthesia and the occurrence of related complications during the examination were compared between the two groups.Results The levels of lactate dehydrogenase (LDH)when leaving the gastroscope room,creatine phosphate kinase(CK)and creatine kinase-MB(CK-MB)in the myocardial enzyme indexes of the observation group were lower than those of the control group,and the differences were statistically significant(P＜0.05).The observation group′s eyeopening time,active response time,and time to leave the gastroscope room were shorter than those of the control group,and the differences were statistically significant(P＜0.05).The proportion of bradycardia and hypotension in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The use of painless gastroscopy and Etomidate for elderly patients with coronary heart disease can effectively reduce the impact on cardiac function,reduce the impact on circulatory function,and promote the patient′s recovery from anesthesia,with fewer complications and high safety.
		2021 Vol. 28 (33): 17-20 [Abstract] ( 44 ) HTML (1 KB) PDF (0 KB) ( 7 )

	21	Effect of photodynamic irradiation combined with electric resection for treating non-muscle invasive bladder cancer and its influence on immune function
		WU Min-hong；FAN Hui-zhen； YU Zhi-ling；GU Hong-yong；LIN Peng-xiu；CHEN Qing-sheng；LIU Cailing；WU Yu-wen
		Objective To investigate the clinical effect of photodynamic irradiation combined with electric resection in the treatment of non-muscle invasive bladder cancer(NMIBC),and its influence on immune function.Methods A total of 60 patients with NMIBC admitted to Yichun People′s Hospital from November 2018 to November 2019 were selected as the research subjects.They were divided into control group and photodynamic group by coin toss method,with 30 patients in each group.The control group was treated with electric resection of tumors and bladder perfusion chemotherapy,while the photodynamic group was treated with photodynamic irradiation combined with electric resection of tumors and bladder perfusion chemotherapy.The levels of T lymphocytes,natural killer(NK)cells,vascular endothelial growth factor and matrix metalloproteinase-9,the total incidence of postoperative complications,recurrence rate and quality of life were compared between the two groups.Results Before treatment,there were no significant differences in the levels of CD3+,CD4+,CD8+,NK cells,vascular endothelial growth factor and matrix metalloproteinase-9 between the two groups(P＞0.05).After treatment,the levels of CD3+,CD4+,CD8+and NK cells in the photodynamic group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The levels of vascular endothelial growth factor and matrix metalloproteinase-9 were lower than those in the control group,and the differences were statistically significant(P＜0.05).The incidence of complications and recurrence rate in the photodynamic group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The quality of life scores of patients in photodynamic group were higher than those in control group,and the differences were statistically significant (P＜0.05).Conclusion Photodynamic irradiation combined with electric resection is markedly effective in the treatment of NMIBC,which can significantly improve the patients′immune function,reduce the incidence of postoperative complications and recurrence rate,and improve quality of life.Therefore,it is worthy of clinical promotion.
		2021 Vol. 28 (33): 21-24转29 [Abstract] ( 38 ) HTML (41 KB) PDF (0 KB) ( 6 )

	25	A meta-analysis of perioperative efficacy of rapid rehabilitation surgical nursing model in in the perioperative period of patients with ovarian cancer
		ZHOU Xiao-ying；HUANG Li-juan；LI Hai-hong； REN Jun-li；LI Yan1YANG Liu
		Objective To evaluate the application effect of rapid rehabilitation surgery (ERAS)nursing model in the perioperative period of patients with ovarian cancer.Methods Eight databases including China national knowledge infrastructure(CNKI),VIP,WanFang Data,Chinese biomedical literature database(CBM),PubMed,Web of Science,Embase and Cochrane Librarywere searched by computer.The clinical trials comparing the perioperative efficacy of ERAS versus conventional care models in ovarian cancer patients were retrieved from the database construction and published in December 2020.Two investigators independently screened the literature,extracted the data,and assessed the risk of bias in the included studies.The outcome indicators included readmission rate at 30 days,time of first postoperative feeding,time of first postoperative exhaust,time of first postoperative defecation,length of hospital stay,etc.Metaanalysis was performed on the included literature data.Results A total of 12 studies involving 1126 patients were included.There were 553 cases in the experimental group and 573 cases in the control group.The results of meta-analysis showed that compared with routine nursing,ERAS group could reduce the 30 day readmission rate (OR=0.32,95%CI[0.15,0.66],P=0.002),shorten the time of first eating after operation(MD=-17.21,95%CI[-18.05,-16.37],P＜0.000 01),shorten the time of first exhaust after operation (MD=-25.27,95%CI[-40.50,-10.04],P=0.001),shorten the first defecation time (MD=-19.35,95%CI[-26.84,-11.86],P＜0.000 01),shorten the hospital stay(MD=-2.07,95%CI[-3.50,-0.64),P=0.005].Conclusion Compared with the conventional nursing mode,the perioperative application of ERAS nursing model for patients with ovarian cancer is a safe and feasible nursing measure,which can reduce the 30-day readmission rate,shorten the postoperative eating time and hospitalization time.
		2021 Vol. 28 (33): 25-29 [Abstract] ( 47 ) HTML (41 KB) PDF (0 KB) ( 11 )

	30	Relationship between serum CA125 level and prognsis in patients with epithelial ovarian carcinoma
		XU Lin ；DIAO Hai-dan
		Objective By investigating the prognostic value of serum carbohydrate antigen 125（CA125）level change in patients with epithelial ovarian carcinoma,find the simple and reliable prognostic indicators.Methods Collected and retrospectively analyzed the clinical dates of 66 patients with epithelial ovarian carcinoma who were treated in the the Third People′s Hospital of Dalian from January 2017 to December 2019.Researched the relationships between preoperative serum CA125 level and recurrence,the rate of descent after one cycle of postoperative chemotherapy and recurrence,whether the serum CA125 level was normal after two cycles of postoperative chemotherapy and recurrence,the half-life (t1/2)of CA125 and recurrence.Results According to the level of preoperative serum CA125,patients were divided into CA125≤500 U/ml group,CA125＞500-1000 U/ml group and CA125＞1000 U/ml group.There was no significant difference in recurrence rate among the three groups(P＞0.05).According to the rate of descent after one cycle of postoperative chemotherapy,patients were divided into CA125 reduction rate≤70% group,CA125 reduction rate 70%-90% group and CA125 reduction rate＞90% group.The recurrence rate of the group with CA125 reduction rate≤70% group was higher than the group with CA125 reduction rate 70%-90% group and CA125 reduction rate＞90% group,and the difference was statistically significant(P＜0.05).According to whether serum CA125 decreased to 35 U/ml after the second course of chemotherapy,the patients were divided into CA125≤35 U/ml group and CA125＞35 U/ml group.The results showed that the recurrence rate of CA125＞35 U/ml group was higher than that of CA125≤35 U/ml group,the difference was statistically significant(P＜0.05).According to the t1/2of CA125,patients were divided into t1/2≤20 d group and t1/2＞20 d group.The results showed that the recurrence rate of t1/2＞20 d group was higher than that of t1/2≤20 d group,and the median time of recurrence was shorter than that of t1/2≤20 d group,the differences were statistically significant(P＜0.05).Conclusion The rate of descent after one cycle of postoperative chemotherapy,whether the serum CA125 level was normal after two cycles of postoperative chemotherapy (35 U/ml as CA125 diagnostic threshold)and the t1/2of CA125 had relationship with prognosis.And they might become the reliable prognostic and recurrent indicators.
		2021 Vol. 28 (33): 30-34 [Abstract] ( 43 ) HTML (44 KB) PDF (0 KB) ( 7 )

	35	Advances in genetic research of familial spontaneous pneumothorax
		KUTULEKE Kuerban； QI Hai
		Studies have found that the incidence of some primary spontaneous pneumothorax is associated with familial inheritance.This assertion was also confirmed in both domestic and international reports.However,genetic studies of familial spontaneous pneumothorax are still in the early stages.This study attempts to analyze the pathogenesis of familial spontaneous pneumothorax from a genetic perspective.In addition,it is expected to grasp and predict the development trend of the disease,so as to provide a reference for more effective and accurate treatment.
		2021 Vol. 28 (33): 35-39 [Abstract] ( 36 ) HTML (43 KB) PDF (0 KB) ( 7 )

	40	Research progress of systematic diagnosis and treatment of femoral neck fracture in young adults
		GAO Feng； WU Xiao-feng ；XU Feng
		Femoral neck fracture is not common in young adults,accounting for 2%～3% of this type of fracture,which is usually caused by high-energy trauma.Usually,the blood supply of fracture end is destroyed greatly,the mechanical stability is poor,and the treatment failure rate is high.However,young and middle-aged patients have high requirements for hip joint function.Therefore,priority should be given to preserving their own joint anatomy and restoring normal joint function.Femoral head ischemia and fracture reduction and fixation failure often lead to nonunion and necrosis of the femoral head.Anatomical reduction and stable internal fixation are the necessary conditions for treatment,However,the timing of operation,reduction method,selection of implants and fixation methods are still controversial.This article will review the diagnosis and classification of femoral neck fracture in young adults,blood supply of femoral head,treatment methods,complication treatment and so on,so as to provide reference for the systematic diagnosis and treatment of this type of fracture.
		2021 Vol. 28 (33): 40-43 [Abstract] ( 49 ) HTML (36 KB) PDF (0 KB) ( 7 )

	44	Clinical comparative study of non-surgical treatment and surgical treatment of uremic hip fracture
		YU Xue-wen； LI Chang-jie； ZHOU Zhong-gang； ZHU Ju-qi；LYU Sui-ben
		Objective To compare the clinical effect of non-surgical treatment and surgical treatment of uremic hip femoral neck fracture.Methods The clinical data of 60 hospitalized patients with uremic hip femoral neck fracture in the Department of Orthopedics and Traumatology of Jiujiang Hospital of Traditional Chinese Medicine from June 2018 to December 2020 were analyzed retrospectively,according to different treatment methods,they were divided into the non-surgical treatment group(30 cases)and the surgical treatment group(30 cases).The non-surgical treatment group was treated with skin traction and bone traction,and the surgical treatment group was treated with cannulated screw internal fixation.The degree of pain and swelling of the two groups before treatment and 1,2 and 4 weeks of treatment were recorded.At the same time,the hip function scores of the two groups at 8 and 12 weeks after treatment were recorded,and the complications of the two groups were observed.Results There were no significant difference in swelling and pain scores between the two groups before treatment and 1 week after treatment(P＞0.05).The swelling and pain scores of the surgical treatment group at 2 and 4 weeks after treatment were lower than those of the non-surgical treatment group,the differences were sta-tistically significant(P＜0.05).There were no significant difference in pain scores of the non-surgical treatment group between 1,2 week after treatment and that before treatment(P＞0.05).There were no significant difference in pain and swelling scores of the non-surgical treatment group between 2 week after treatment and 1 week after treatment(P＞0.05).The pain score of the non-surgical treatment group after 4 weeks of treatment was lower than that before treatment,the difference was statistically significant(P＜0.05).The pain and swelling scores of the non-surgical treatment group at 4 weeks after treatment were lower than those at 1 and 2 weeks after treatment,the differences were statistically significant(P＜0.05).The swelling scores of the non-surgical treatment group at 1,2 and 4 weeks after treatment were lower than those before treatment,the differences were statistically significant(P＜0.05).There was no significant difference in pain score of the surgical treatment group between 1 week after treatment and that before treatment(P＞0.05).The swelling score of the surgical treatment group at 1 week after treatment was lower than that before treatment,the difference was statistically significant(P＜0.05).The swelling and pain scores in the surgical treatment group at 2 and 4 weeks after treatment were lower than those before treatment,the differences were statistically significant(P＜0.05).The scores of pain and swelling in the surgical treatment group after 2 weeks of treatment were lower than those after 1 week of treatment,the differences were statistically significant(P＜0.05).The swelling and pain scores of the surgical treatment group at 4 weeks after treatment were lower than those at 1 and 2 weeks after treatment,the differences were statistically significant(P＜0.05).The hip function score of the two groups at 12 weeks of treatment were higher than those at 8 weeks of treatment,the differences were statistically significant(P＜0.05).The hip function score of the surgical treatment group was higher than that of the non-surgical treatment group at 8 and 12 weeks,the differences were statistically significant(P＜0.05).The hip function score of the surgical treatment group at 8 and 12 weeks of treatment were higher than those of the non-surgical treatment group,the differences were statistically significant(P＜0.05).12 weeks after treatment,the total incidence of complications in the surgical treatment group was 10.00%,which was lower than 33.33% in the non-surgical treatment group,the difference was statistically significant(P＜0.05).Conclusion For patients with uremic hip femoral neck fracture,surgical treatment can quickly reduce the pain and swelling of patients,promote the recovery of hip function,and the total incidence of complications is low.It can be used as the first choice of treatment.
		2021 Vol. 28 (33): 44-48 [Abstract] ( 37 ) HTML (39 KB) PDF (0 KB) ( 7 )

	49	Application of Maslow theory in the intervention of colonoscopy bowel preparation in elderly patients
		LI Jun-yu； XU Zhong-jun ；LU Wei；WANG Yan-qing； HUANG Yan-bing ；XIE Jun； XIE Yun； JIANG Da-liang
		Objective To explore the application and effect of Maslow′s theory based intervention on colonoscopy bowel preparation in elderly patients.Methods A total of 140 patients who were admitted to the Department of Gastroenterology,the First Affiliated Hospital of Gannan Medical College for colonoscopy from December 2019 to February 2021 were randomly divided into the observation group (n=70)and the control group (n=70)according to random number table method.The control group received routine bowel preparation scheme,and the observation group received personalized bowel preparation scheme for elderly patients based on Maslow theory.The qualified rate of intestinal preparation,the detection rate of intestinal polyps,the total incidence of adverse reactions and the total satisfaction of the medical experience were compared between the two groups.Results The qualified rate of intestinal preparation in the observation group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).The number of intestinal polyps detected in the observation group was significantly higher than that in the control group,the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was significantly lower than that in the control group,the difference was statistically significant(P＜0.05).The satisfaction of the observation group was significantly higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion The individualized bowel preparation scheme for elderly patients based on Maslow theory can improve the qualified rate of bowel preparation,the number of intestinal polyps detected,improve life satisfaction and reduce the incidence of adverse reactions,which has good clinical application value.
		2021 Vol. 28 (33): 49-52 [Abstract] ( 42 ) HTML (35 KB) PDF (0 KB) ( 7 )

	53	Application of S.T.O.N.E kidney stone scoring system in MPCNL treatment of kidney stones after upper urinary tract open operatien
		ZHAO Hua
		Objective To investigate the stone removal rate and complications correlation of S.T.O.N.E scoring system in minimally invasive percutaneous nephroscope technique(MPCNL)treatment of renal calculi after upper urinary tract opening.Methods Retrospective analysis of the data of 82 patients with renal calculi who received MPCNL from the same group of doctors in the Department of Urology,Pingxiang People′s Hospital from January 2014 to January 2020.According to the status of postoperative stone removal,they were divided into the stone removal group (57 cases)and the stone residue group (25 cases).According to the occurrence of postoperative complications,the selected patients were divided into the complication group(38 cases)and the non-complication group(44 cases).At the same time,the postoperative complications were graded according to Clavien classification system,the patients were divided into the mild complication group(23 cases)and the severe complication group(15 cases).The S.T.O.N.E.renal stone scores of the stone removal group and the stone residue group,and the differences of S.T.O.N.E.renal stone scores between the non-complication group,the mild complication group and the severe complication group were compared,and the relationship between S.T.O.N.E.score and stone removal rate and postoperative complications was analyzed.Results The scores of S,N,E and total score of the stone removal group were lower than those of stone residue group,the differences were statistically significant(P＜0.05).The stone clearance rate were related to S.T.O.N.E.score,S score,N score and E score(P＜0.05).The stone clearance rate had no relationship with T score and O score(P＞0.05).Logistic regression analysis showed that S.T.O.N.E.score,S score,N score and E score were the risk factors of stone clearance(P＜0.05).Pearson correlation analysis showed that S.T.O.N.E.score was negatively correlated with stone clearance (r=-0.712,P=0.018),S score was negatively correlated with stone clearance(r=-0.685,P=0.021),N score was negatively correlated with stone clearance(r=-0.637,P=0.025),and E score was negatively correlated with stone clearance(r=-0.526,P=0.034).There was no significant difference in the scores of S.T.O.N.E.scoring system between the uncomplicated group,the mild complication group and the severe complication group (P＞0.05),And there was no statistically significant difference in S.T.O.N.E.scoring system scores between the three groups pairwise comparison(P>0.05).S.T.O.N.E.score,S score,T score,O score,N score and E score were not risk factors for complications(P＞0.05).Conclusion S.T.O.N.E.scoring system has a negative correlation with the stone removal rate of renal calculi after upper urinary tract opening in MPCNL treatment,but the correlation with complications needs to be further verified.
		2021 Vol. 28 (33): 53-56 [Abstract] ( 48 ) HTML (35 KB) PDF (0 KB) ( 7 )

	57	Observation on the effect of directional diathermy combined with hot pack in promoting ureteral calculi expulsion
		WAN Li-na； ZHANG Jian-hua； LI Qing
		Objective To investigate the effect of directional diathermy combined with hot pack in promoting ureteral stone expulsion.Methods A total of 200 patients with ureteral calculi admitted to Nanchang Stone Disease Hospital from January 2019 to January 2020 were selected as the study subjects and divided into the observation group (n=100)and the control group (n=100)according to the random number table.The control group was treated with routine treatment,and directional diathermy combined with hot pack treatment was used on this basis.The clinical efficacy,analgesic drug use rate,stone expulsion rate,stone expulsion time,clinical symptom relief time,and quality of life were compared between the two groups.Results The total effective rate of treatment observation group was higher than that in control group,the difference was statistically significant(P＜0.05).The use rate of analgesic drugs in observation group was lower than that in control group,the stone expulsion rate was higher than that in control group,the differences were statistically significant(P＜0.05).The time to discharge stones and the time to relieve low back pain,hematuria,frequent urination and urgency in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).After 3 months of treatment,the scores of social function,physical function,role function,and emotional function of the two groups were higher than those of this group before treatment,and the observation group was higher than the control group,the differences were statistically significant(P＜0.05).Conclusion Directional diathermy combined with hot pack is effective in the treatment of ureteral calculi,which can improve the stone clearance rate,reduce the use of analgesic drugs,shorten the stone expulsion time,clinical symptom relief time and improve the quality of life.
		2021 Vol. 28 (33): 57-60 [Abstract] ( 47 ) HTML (35 KB) PDF (0 KB) ( 8 )

	61	Effect of Fluvoxamine Maleate Tablets combined with low-dose Mirtazapine Tablets on depressive symptoms,physical pain and quality of life in patients with depression with physical pain
		FANG Feng-feng； LAN Li-ping ；LAI Yun-juan ；YAO Su-hua； HUANG Li；ZHANG Yang-zheng-hao； CHEN Ji-xiang； LI Yang
		Objective To investigate the effects of Fluvoxamine Maleate Tablets combined with low-dose Mirtazapine Tablets on depressive symptoms,physical pain and quality of life in patients with depression with physical pain.Methods From July 2019 to August 2020,a total of 80 patients with depression and physical pain who were admitted to the Department of Psychiatry,the Third People′s Hospital of Ganzhou were selected as the research objects.According to the random number table,they were divided into control group and observation group,with 40 cases in each group.The control group used Fluvoxamine Maleate Tablets,and the observation group used low-dose Mirtazapine Tablets in addition to the control group.The Hamilton depression scale(HAMD),visual analogue scale(VAS)and the 36-Item short form health survey(SF-36)score changes between the two groups during treatment were compared,and adverse reactions occurred during the treatment of the two groups were counted.Results At 2,4,6 and 8 weeks after treatment,the HAMD and VAS scores of the observation group were lower than those of the control group,and the SF-36 scores were higher than that of the control group,the differences were statistically significant(P＜0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups during treatment(P＞0.05).Conclusion For depression patients with physical pain symptoms,the use of Fluvoxamine Maleate Tablets combined with low-dose Mirtazapine Tablets can effectively improve the patient′s depression,relieve body pain,improve quality of life without increasing complications Rate and safety are high.
		2021 Vol. 28 (33): 61-63转75 [Abstract] ( 89 ) HTML (30 KB) PDF (0 KB) ( 9 )

	64	Influencing factors of prognosis of patients with AIDS combined with perianal abscess
		ZHENG Lu；CHEN Jiang-qing；OUYANG Shui-ming；ZHANG Quan-hui；HUANG Yi-hua；WU Xiao-ping
		Objective To explore the Influencing factors of prognosis of patients with acquired immune deficiency syndrome combined with perianal abscess.Methods A total of 60 patients with acquired immune deficiency syndrome complicated with perianal abscess admitted to the Ninth Hospital of Nanchang from May 2019 to December 2020 were selected as the observation group,and 60 patients with a simple perianal abscess without acquired immune deficiency syndrome admitted to Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine at the same period were selected as the control group.The prognosis of the two groups was compared,and the influencing factors of the prognosis of acquired immune deficiency syndrome patients with perianal abscess were analyzed.Results The incidence of poor prognosis in the observation group was higher than that in the control group,the difference was statistically significant(P＜0.05).Logistic regression analysis showed that older age,the number of CD4+cells ＜150 cells/μL,no acceptance antiviral treatment,high level of white blood cell count(WBC),high level of interleukin-6(IL-6)and high level of interleukin-10 (IL-10)were the influencing factors of poor prognosis in acquired immune deficiency syndrome patients with perianal abscess(OR＞1,P＜0.05).Conclusion Acquired immune deficiency syndrome patients with perianal abscess have a higher incidence of poor prognosis,older age,and number of CD4+cells ＜150 cells/μL no perianal abscess,high WBC level,high IL-6 level and high IL-10 level are acquired immune deficiency syndrome Influencing factors for the poor prognosis of patients with perianal abscess.The clinical should pay attention to the above factors and actively give corresponding intervention measures to improve the prognosis.
		2021 Vol. 28 (33): 64-67转79 [Abstract] ( 50 ) HTML (38 KB) PDF (0 KB) ( 5 )

	68	Clinical effect of Xiaoying Ruanjian Powder combined with Methimazole on hyperthyroidism
		YANG Yue；YAO Xiao-wen； YANG Jun-yao；ZHANG Yao-ting；ZHANG Jue；ZHONG Ming-mei
		Objective To explore the clinical effect of Xiaoying Ruanjian Powder combined with Methimazole in the treatment of hyperthyroidism.Methods A total of 60 hyperthyroidism patients were admitted to Pingxiang Hospital of Traditional Chinese Medicine from January 2016 to December 2019 were selected as the research objects.They were divided into the control group (30 cases)and the treatment group (30 cases)according to coin flipping method.The control group was given oral Methimazole tablets for 1.5 years.The treatment group was given the same treatment as the control group,plus Xiaoying Ruanjian Powder for 8 weeks.The treatment effect,thyroid function,thyroid related antibody,thyroid volume changes and disease recurrence within 6 months after treatment were compared between the two groups after 8 weeks.Results Total effective rate of the treatment group was higher than that of the control group,with statistically significant difference (P＜0.05).Before treatment,there were no statistically significant differences of the serum free triiodothyronine(FT3),free thyroid hormone(FT4),thyroid-stimulating hormone(TSH),thyrotropin receptor antibody (TRAb)between the two groups(P＞0.05).After treatment,the levels of the FT3,FT4,TSH,TRAb of the two groups were lower than those before treatment,with statistically significant differences (P＜0.05).After treatment,the levels of the FT3,FT4,TSH,TRAb of the treatment group were lower than those of the control group in the same period,with statistically significant differences(P＜0.05).Before treatment,there was no statistically significant difference of the thyroid volume between the two groups (P＞0.05).After treatment,the thyroid volume of the two groups were smaller than those before treatment,and the thyroid volume of the treatment group was smaller than that of the control group in the same period,with statistically significant differences(P＜0.05).The recurernce rate of the treatment group was lower than that of the control group,with statistically significant difference (P＜0.05).Conclusion Compared with Xiaoying Ruanjian Powder combined with oral Methimazole,oral Methimazole combined with external application in the treatment of hyperthyroidism can improve the clinical symptoms and thyroid function of patients with hyperthyroidism more effectively and reduce the recurrence rate of the disease.
		2021 Vol. 28 (33): 68-71 [Abstract] ( 43 ) HTML (37 KB) PDF (0 KB) ( 7 )

	72	Value of C-reactive protein,D-dimer combined with procalcitonin in judging the severity of early acute pancreatitis
		MA Lin
		Objective To explore the value of C-reactive protein,D-dimer combined with procalcitonin in judging the severity of early acute pancreatitis.Methods The clinical data of 69 patients with acute pancreatitis admitted to Hai′an Hospital Affiliated to Nantong University from March 2017 to March 2020 were retrospectively analyzed.The patients were divided into mild acute pancreatitis(MAP)group(n=28),moderate severe acute pancreatitis(MSAP)group(n=25)and severe acute pancreatitis(SAP)group (n=16)according to 2019 Chinese guidelines for diagnosis and treatment of acute pancreatitis.The levels of C-reactive protein,D-dimer and procalcitonin in the three groups were analyzed,and the diagnostic value of the combined detection of the three groups of indicators was analyzed.Results C-reactive protein,D-dimer and procalcitonin in SAP group and MSAP group were higher than those in MAP group,while C-reactive protein,D-dimer and procalcitonin in SAP group were higher than those in MSAP group,the differences were statistically significant (P＜0.05).The sensitivity,specificity and accuracy of the combined detection of three indexes for severe acute pancreatitis were 93.75%,100% and 98.55%.Multivariate logistic analysis showed that D-dimer （β=2.330，OR=4.575，95%CI=1.354-7.957）,C-reactive protein （β=1.125，OR=4.182，95%CI=1.538-6.175）and procalcitonin （β=2.232，OR=3.869，95%CI=1.287-7.203）were independent influencing factors of SAP (P＜0.05).Conclusion Compared with the single index or the combination of two indexes,the combined detection of C-reactive protein+D-dimer+procalcitonin is more accurate in judging the severity of acute pancreatitis,which is worthy of clinical promotion.
		2021 Vol. 28 (33): 72-75 [Abstract] ( 46 ) HTML (34 KB) PDF (0 KB) ( 9 )

	76	Effect of monoclonal antibody and polyclonal antibody on procalcitonin in renal transplantation patients
		WANG Si-qi；CHEN Wen-li；TAI Qiang
		Objective To investigate the effect of monoclonal antibody and polyclonal antibody on procalcitonin in renal transplantation patients.Methods A total of 101 renal transplant patients admitted to the First Affiliated Hospital of Sun Yat-sen University from June 2017 to June 2020 were retrospectively selected as the subjects.According to the immunosuppressive treatment regimen,the patients were divided into monoclonal antibody group(n=50)and polyclonal antibody group (n=51).The monoclonal antibody group was treated with Basiliximab,and the polyclonal group was treated with Anti-human Thymocyte Immunoglobulin.The levels of procalcitonin,creatinine,urea nitrogen were compared between the two groups after renal transplantation.Results There was no significant difference in procalcitonin level between the two groups 1-4 days after operation (P＞0.05).The level of procalcitonin in the polyclonal group was significantly higher than that in the monoclonal group at 5-6 days after operation,with statistical significance(P＜0.05).At 5-7 days after surgery,the level of procalcitonin in both groups was lower than that at 1 day after surgery,with statistical significance (P＜0.05).There were no significant differences in creatinine and urea nitrogen between the two groups at 1-7 days after operation (P＞0.05).At 6-7 days after surgery,creatinine level in both groups was lower than that at 1 day after surgery,with statistical significance (P＜0.05).On day 7 after surgery,the level of urea nitrogen in the two groups was lower than that on day 1 after surgery,the difference was statistically significant(P＜0.05).Conclusion Immunosuppressant can increase procalcitonin.Polyclonal antibodies have a greater effect on the fluctuation of procalcitonin levels than monoclonal antibodies.
		2021 Vol. 28 (33): 76-79 [Abstract] ( 38 ) HTML (35 KB) PDF (0 KB) ( 7 )

	80	Application effect of rehabilitation therapy combined with home training guidance on WeChat platform in patients with frozen shoulder
		BAI Jin-chen； LI Ying
		Objective To explore the application effect of rehabilitation therapy combined with home training guidance on WeChat platform in patients with frozen shoulder.Methods A total of 60 patients with frozen shoulder treated in the rehabilitation department of Tianjin Hospital from March 2019 to March 2021 were selected as the research objects.The patients were randomly divided into experimental group(30 cases)and control group(30 cases)by random number table method.Patients in the control group received rehabilitation therapy,and patients in the experimental group received rehabilitation therapy combined with WeChat platform home training guidance.The shoulder range of motion and visual analogue scale (VAS)were compared between two groups.Results After the intervention,the VAS score of the experimental group was significantly lower than that of the control group,the difference was statistically significant(P＜0.05).The flexion,abduction,extension,internal rotation and external rotation angles of shoulder in experimental group were greater than those of the control group,the differences were statistically significant(P＜0.05).Conclusion Rehabilitation combined with training guidance on WeChat platform can effectively relieve the pain of frozen shoulder and improve the range of motion of shoulder joint.
		2021 Vol. 28 (33): 80-83 [Abstract] ( 45 ) HTML (34 KB) PDF (0 KB) ( 6 )

	84	Application of modified continuous suture method in endoscopic submucosal dissection
		LIU Xue； WEN Jian-jun； YE Xiao-hui；SHI Liu； ZHANG Jing-zhi
		Objective To explore the clinical application value of modified continuous suture method in endoscopic submucosal dissection.Methods From March to August 2020,60 patients with gastric submucosal tumors who were hospitalized in the Department of Gastroenterology,People′s Hospital of Ganzhou City were selected as the research objects.According to the random number table,they were divided into the observation group and the control group,with 30 cases in each group.All patients underwent endoscopic submucosal dissection.The wounds of the control group were treated with nylon string purse string suture,and the wounds of the observation group were treated with modified continuous suture.The wound diameter,wound suture time,hospitalization cost,wound healing and postoperative complications were compared between the two groups.Results There was no statistically significant difference in wound diameter between the two groups (P＞0.05).The wound suture time in the observation group was shorter than that in the control group,and the hospitalization cost was lower than that in the control group,and the differences were statistically significant(P＜0.05).The total incidence of complications in observation group was higher than that in control group,and the difference was statistically significant(P＜0.05).There were no residual lesions or recurrence occurred in both groups after reexamination.Conclusion The improved continuous suture method used in endoscopic submucosal dissection can effectively close the wound,is economical and safe,and has clinical promotion value.
		2021 Vol. 28 (33): 84-86 [Abstract] ( 48 ) HTML (32 KB) PDF (0 KB) ( 7 )

	87	Effect comparison between percutaneous and choledocholithotomy for recurrent choledocholithiasis
		WU Hao-rong； LI Xiao-hui；ZHANG Jian
		Objective To investigate the effect of percutaneous choledocholithiasis and choledocholithotomy in the treatment of recurrent choledocholithiasis.Methods A retrospective analysis was performed on 80 patients with recurrent common bile duct stones admitted to People′s Hospital of Puning City from January 2018 to January 2020,who were divided into intervention group(45 cases)and control group(35 cases)according to different surgical methods.Patients in the control group received choledocholithotomy,and patients in the intervention group received percutaneous and hepatobiliary lithotomy.Operation,liver function,stone removal rate and postoperative complications were compared between the two groups.Results The operation time,hospital stay and postoperative exhaust time of patients in the intervention group were shorter than those in the control group,the amount of intraoperative blood loss was less than that in the control group,and the postoperative pain score was lower than that in the control group,the differences were statistically significant(P＜0.05).The total bilirubin(TBil),alanine aminotransferase(ALT)and aspartate aminotransferase (AST)levels in the two groups at 1 and 7 days after surgery were lower than those before surgery,and the differences were statistically significant(P＜0.05).There were no statistically significant differences in TBil,ALT and AST between the two groups before surgery,1 and 7 d after surgery(P＞0.05).There were no statistically significant differences in stone removal rate and total incidence of postoperative complications between the two groups (P＞0.05).Conclusion Both percutaneous and choledocholithotomy for the treatment of recurrent choledocholithiasis have significant effects,with little impact on liver function and high safety.However,patients treated by percutaneous and choledocholithotomy have faster postoperative recovery and significantly shorter hospital stay.
		2021 Vol. 28 (33): 87-89转93 [Abstract] ( 40 ) HTML (32 KB) PDF (0 KB) ( 6 )

	90	Clinical application of prone position and low-concentration Ropivacaine under epidural anesthesia for the treatment of lumbar intervertebral disc herniation
		LIU Hui；LI Hong ；XIONG Zhi-peng
		Objective To explore the clinical application of prone position and low-concentration ropivacaine under epidural anesthesia for the treatment of lumbar intervertebral disc herniation with intervertebral foraminoscope.Methods A total of 97 patients with lumbar intervertebral disc herniation in Second People′s Hospital of Pingxiang City from August to December 2020 were selected and divided into the project group(48 cases)and the control group(49 cases)according to random number table method.Both groups underwent foraminal discectomy at the same time.The control group was in the lateral position and received local anesthesia with Lidocaine,and the project group was in the prone position and epidural anesthesia with Ropivacaine.The visual analogue scales(VAS)scores at 6,12 and 24 hours after surgery,the indicators of vital signs at the time of pre-anesthesia (T0),surgery begins skin ision (T1),intraoperative clamping of the nucleus pulposus to pull the nerve root(T2),suture at the end of the operation (T3),and postoperative adverse reactions occurred at 24 hours after surgery.Results The VAS scores at 12 and 24 hours after surgery of both groups were lower than 6 hours after surgery in this group,the VAS scores at 24 hours after surgery of both groups were lower than 12 hours after surgery in the group,and the VAS score of 6,12 and 24 hours after surgery in the project group was lower than those in the control group in the control group at the same period,the differences were statistically significant(P＜0.05).At T0,the two groups were compared with mean arterial pressure (MAP)and heart rate(HR),with no statistically significant difference(P＞0.05).At T1,T2,T3,the MAP and HR in the project group were lower than those in the control group at the same period,and differences were statistically significant(P＜0.05).The MAP and HR of the project group at T1were lower than those at T0in this group,the MAP and HR of the project group at T2were higher than those at T0in this group,the MAP of the project group at T3was higher than that at T0in this group,the HR of the project group at T3were lower than that at T0in this group,the MAP and HR of the project group at T3were higher than those at T2in this group,and differences were statistically significant(P＜0.05).The MAP and HR of the control group at T1,T2,T3were higher than those at T0in this group,the MAP and HR of the control group at T2,T3were higher than those at T1in this group,the MAP and HR of the control group at T3were lower than those at T2in this group,and differences were statistically significant(P＜0.05).The total incidence of adverse reactions of the project group was lower than that of the control group,with statistically significant difference (P＜0.05).Conclusion The prone position and low-concentration ropivacaine epidural anesthesia can significantly reduce the pain of patients with lumbar disc herniation during foraminal endoscopy,while maintaining the patient′s normal level of vital signs,which is safer.
		2021 Vol. 28 (33): 90-93 [Abstract] ( 38 ) HTML (41 KB) PDF (0 KB) ( 5 )

	94	Effect of micro class health education and core stability training on the vertebral function and pain degree of lumbar disc herniation patients
		ZHOU Wen-ying；LUO Ting；ZHOU Qi-zhen
		Objective To investigate the effect of micro class health education and core stability training on the vertebral function and pain degree of lumbar disc herniation patients.Methods A total 94 patients with lumbar disc herniation treated in Jiujiang Hospital of Traditional Chinese Medicine from June 2018 to October 2020 were selected as the research objects,and they were divided into the control group(47 cases)and the observation group(47 cases)according to the random number table method.The control group was given routine health education and massage therapy,the observation group was given micro class health education combined with core stable training on the basis of the control group,and the intervention time was 8 weeks.The vertebral function (the lumbar function score table of the Japanese Orthopaedic Association [JOA]scores),pain degree (oswestry dysfunction index [ODI])and rehabilitation knowledge mastery were compared before and after intervention.Results Before intervention,there were no significant differences in JOA score and ODI between the two groups(P＞0.05).After the intervention,the JOA score of the observation group was higher than that of the control group,and the ODI was lower than that of the control group,the differences were statistically significant(P＜0.05).The scores of disease knowledge,rehabilitation skills and emotional knowledge in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).Conclusion The combination of micro class health education and core stability training can effectively improve the rehabilitation knowledge of patients with lumbar disc herniation,improve the vertebral function and reduce the pain.
		2021 Vol. 28 (33): 94-96 [Abstract] ( 49 ) HTML (31 KB) PDF (0 KB) ( 7 )

	97	Clinical effect of anti-rotation intramedullary nail and anatomical locking plate on the treatment of femoral intertrochanteric fractures
		CHEN Feng-hua； LU Chen-xing
		Objective To investigate the clinical effect of proximal femoral anti-rotation intramedullary nail and anatomical locking plate in the treatment of femoral intertrochanteric fractures.Methods A total of 65 patients with intertrochanteric fractures of the femur admitted to Taizhou Hospital of Traditional Chinese Medicine from January 2015 to June 2020 were selected as the research objects.They were divided into the observation group(n=33)and the control group (n=32)according to the random number table method.The observation group used the proximal femoral nail antirotation (PFNA)technical plan,and the control group used the anatomical locking plate technical plan.The surgical indicators(operation time,intraoperative bleeding,time of load departure,days of hospitalization),bone metabolism indicators before and after surgery (β-carboxyterminal telopeptide oftype I collagen (CTX),procollagen I N-terminal propeptide(PINP]),levels of inflammatory factors before and after surgery(Interleukin-6[IL-6],tumor necrosis factorα [TNF-α]),the excellent and good rate of surgery,and the total incidence of complications were compared between the two groups.Results The operation time,time of load departure,days of hospitalization of the observation group were shorter than those of the control group,and the intraoperative bleeding of the observation group was less than that of the control group,with statistically significant differences(P＜0.05).Before surgery,there were no statistically significant differences of CTX,PINP between the two groups (P＞0.05).After surgery,the CTX of the two groups was lower than that before surgery,the PINP of the two groups was higher than that before surgery,and the CTX of the observation groups was lower than that of the control group in the same period,the PINP of the observation groups was higher than that of the control group in the same period,with statistically significant differences (P＜0.05).Before surgery,there were no statistically significant differences of IL-6,TNF-α between the two groups(P＞0.05).After surgery,the IL-6 and TNF-α of the two groups were higher than those before surgery in the group,but the IL-6 and TNF-α of the observation groups was lower than that of the control group in the same period,with statistically significant differences(P＜0.05).There was no statistically significant difference in the excellent and good rate between the two groups (P＞0.05).The total survival rate of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion The application of PFNA technology for intertrochanteric fractures of the femur can improve the quality of surgery and bone metabolism,reduce inflammation,enhance the effect of surgery,and prevent surgical complications compared with the anatomical locking plate technology.
		2021 Vol. 28 (33): 97-100 [Abstract] ( 37 ) HTML (36 KB) PDF (0 KB) ( 5 )

	101	Efficacy and safety analysis of different approaches of laparoscopic radical prostatectomy in the treatment of prostate cancer
		ZHOU Chang-dong； TIAN Yu-xin； YANG Xin-ping； ZHANG Qi-fu
		Objective To analyze and explore the effect and safety of laparoscopic radical prostatectomy in the treatment of prostate cancer.Methods A total of 66 patients with prostate cancer in the Department of Urology of Jilin Cancer Hospital from September 2017 to September 2019 were selected as the research objects.They were divided into the control group and the observation group by random number table method,with 33 cases in each group.The patients in the control group were treated with laparoscopic radical prostatectomy via abdominal approach,and the patients in the observation group were treated with laparoscopic radical prostatectomy via extraperitoneal approach.Surgical indicators,complications,positive rate of surgical margin and total effective rate were compared between the two groups.Results The operation time,postoperative catheter indwelling time,postoperative fluid feeding time,postoperative drainage tube removal time and hospital stay in the observation group were shorter than those in the control group,and the differences were statistically significant(P＜0.05).There was no statistically significant difference in intraoperative blood loss between the two groups(P＞0.05).The total incidence of complications in observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the positive rate of surgical margin between the two groups(P＞0.05).The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P＜0.05).Conclusion The effect of extraperitoneal laparoscopic radical prostatectomy in the treatment of prostate cancer is remarkable and worthy of clinical implementation and development.
		2021 Vol. 28 (33): 101-103转107 [Abstract] ( 45 ) HTML (31 KB) PDF (0 KB) ( 7 )

	104	Expression of DEPDC1B in bladder cancer and its clinical correlation
		WU Yi-gao；ZHAO Yong-bin； HU Wei-lie
		Objective To explore the expression of DEPDC1B in bladder cancer and its clinical relevance.Methods A total of 153 cases of bladder cancer from January 2015 to December 2020 in the oncology department of our hospital were randomly selected as the research objects.The mRNA levels of DEPDC1B,NF-κB and ERK1/2 were detected by qRT-PCR,and the protein levels of depdc1b were detected by Western Blot.Results The level of mRNR of DEPDC1B in the cystic cancer tissue was higher than that in the paracellular tissue of carcinoma,with statistical significant difference (P＜0.05).The protein expression level of DEPDC1B in the cystic cancer tissue was higher than that in the paracellular tissue of carcinoma,with statistical significant difference (P＜0.05).The degree of differentiation and TNM grade of bladder cancer of the DEPDC1B high-expression group were higher than those of the DEPDC1B low-expression group,with statistical significant differences(P＜0.05).There were no correlation between DEPDC1B expression with age,sex,tumor size,and number of patients with bladder cancer(P＞0.05).The mRNA levels of Rac1 and ERK1/2 in the bladder cancer tissues were higher than those in the paracellular tissue of carcinoma,with statistical significant differences(P＜0.05).Conclusion DEPDC1B is highly expressed in bladder cancer and is closely related to the progression of bladder cancer.DEPDC1B may play a role in promoting cancer by activating Rac1 and ERK1/2.
		2021 Vol. 28 (33): 104-107 [Abstract] ( 36 ) HTML (30 KB) PDF (0 KB) ( 7 )

	108	Effect of immune-enhancing enteral nutrition support combined with chemotherapy on nutritional status and immune function of elderly patients with advanced colorectal cancer
		ZUO Hao；YAN Dong-sheng；LI Xiang-wei；MA Tian-heng
		Objective To explore the effect of immune-enhancing enteral nutrition support combined with chemotherapy on the nutritional status and immune function of elderly patients with advanced colorectal cancer.Methods Sixty elderly patients with advanced colorectal cancer who were treated at Huai′an First Hospital Affiliated to Nanjing Medical University from May 2017 to May 2020 were selected as the research objects.All patients were divided into observation group and control group according to the random number table method,with 30 cases in each group.The control group received chemotherapy,the observation group was combined with immune-enhanced enteral nutrition support on the basis of the control group.Nutritional status indicators(body mass index[BMI],albumin[Alb]content,transferrin[TF]content),immune function indicators(T lymphocyte[CD3+,CD4+,CD8+])levels and complications were compared between the two groups before and after treatment.Quality of life score (Karnofsky [KPS],Zubrod performance status[ZPS],quality of life score [QOL])was used to evaluate the prognosis.Results After treatment,BMI,Alb,TF,CD3+,CD4+,CD8+,KPS and QOL scores of observation group were higher than those of control group,and the ZPS scores were lower than those of the control group,the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was 10.00%(3/30),lower than 26.67% (8/30)in the control group,and the difference was statistically significant(P＜0.05).Conclusion Immune-enhancing enteral nutrition support com-bined with chemotherapy can effectively improve the nutritional status and immune function of patients,and can promote the smooth implementation of treatments.After the combined treatment of the two,the risk of complications is lower and the quality of life has also been significantly improved.This therapy has high clinical value and it is recommended to be further promoted and applied.
		2021 Vol. 28 (33): 108-111 [Abstract] ( 35 ) HTML (39 KB) PDF (0 KB) ( 7 )

	112	Analysis of related factors of stillbirth in pregnant women with HELLP syndrome
		LIU Wei；ZHU Yi-rong ；CHEN Jin▲
		Objective To investigate the related factors of stillbirth in pregnant women with HELLP syndrome.Methods A total of 84 cases of HELLP syndrome admitted into Jiangxi Maternal and Child Health Hospital from January 2015 to March 2021 were selected as the research objects,and 19 cases of neonatal death were defined as the observation group,while 65 cases of neonatal survival were defined as the control group.The logistic regression model was used to analyze the correlation between 21 clinical data indexes and stillbirth.Results The singe-factor analysis showed that the differences were not statistically significant in the age,menarche age,gravidity,serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),lactate dehydrogenase(LDH),alkaline phosphatase(ALP),γ-glutamyl transpeptidase(GGT)and prealbumin(PA),plasma prothrombin time(PT)and activated partial thromboplastin time(APTT),the incidence rates of premature delivery,fetal distress and oligohydramnios between the 2 groups(P＞0.05).The parity,systolic blood pressure(SBP),diastolic blood pressure(DBP),serum total bilirubin(TBil)of the observation group were higher than those of the control group,while the whole blood hemoglobin(Hb),platelet(PLT)and plasma fibrinogen(Fbg)were lower than those of the control group,the differences were statistically significant(P＜0.05).The multivariate logistic analysis showed that the SBP,DBP and serum TBil were independent risk factors of stillbirth in pregnant women with HELLP syndrome(P＜0.05),while the whole blood Hb,PLT and plasma Fbg were independent protective factors(P＜0.05).Conclusion There are many related factors of stillbirth in women with HELLP syndrome,and some clinical intervention measures can be targeted to improve the prognosis of pregnancy.
		2021 Vol. 28 (33): 112-114转118 [Abstract] ( 47 ) HTML (30 KB) PDF (0 KB) ( 8 )

	115	Application effect of multidisciplinary collaborative diagnosis and treatment model in the diagnosis and treatment of patients with placenta previa combined with placental implantation
		ZHOU Pei-shan； CHEN Hai-ju； ZHENG Yan-le
		Objective To explore the application value of multidisciplinary collaborative diagnosis and treatment model in the diagnosis and treatment of placenta previa combined with placental implantation.Methods A total of 60 patients with placenta previa combined with placental implantation who were selected from the Guangdong Jieyang People′s Hospital from January 2015 to February 2021.They were divided into the control group (30 cases)and the observation group(30 cases)by the random number table method.The control group was given regular diagnosis and treatment,and the observation group was given the multidisciplinary collaborative diagnosis and treatment model.Both groups were intervened for two weeks.The postpartum bleeding rate,bleeding volume,blood transfusion rate,hysterectomy and neonatal prognosis were compared between the two groups.Results The postpartum bleeding rate,bleeding excess rate,blood transfusion rate,and hysterectomy rate in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The 5 min Apgar score of the newborns in the observation group was higher than that in the control group,and the neonatal asphyxia rate was lower than that in the control group,the differences were statistically significant(P＜0.05).Conclusion In the diagnosis and treatment of placenta previa combined with placental implantation,the use of multidisciplinary collaborative diagnosis and treatment model can effectively improve the adverse pregnancy outcome and reduce neonatal asphyxia.
		2021 Vol. 28 (33): 115-118 [Abstract] ( 44 ) HTML (32 KB) PDF (0 KB) ( 5 )

	119	Effect of shoulder delivery during uterine contraction and traditional shoulder delivery methods on natural delivery newborn
		WANG Ying； CAO Yan-hua； SONG Wei；LIN Shu； LI Hai-ying
		Objective To study the effect of shoulder delivery and traditional shoulder delivery on natural delivery of newborns.Methods The clinical data of 150 parturients who gave birth naturally from January to June 2019 in Chunliu District of Dalian Women and Children Medical Center(Group)were retrospectively analyzed.According to the way of shoulder delivery,they were divided into study group (n=75)and control group (n=75).The control group adopted the traditional shoulder delivery method,and the study group adopted the uterine contraction stage delivery method.The neonatal asphyxia of the two groups were compared,and the incidence of neonatal labor injury and complications of two groups were counted.Results The incidence of neonatal birth injury in the study group was lower than that in the control group,the difference was statistically significant(P＜0.05).The total incidence of neonatal asphyxia in the study group was lower than that in the control group,the difference was statistically significant(P＜0.05).The total incidence of neonatal complications in the study group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Compared with the traditional methods of shoulder delivery,shoulder delivery during uterine contraction is helpful to reduce neonatal asphyxia and the incidences of labor injury and related complications,it has strong research value and clinical value.
		2021 Vol. 28 (33): 119-121转125 [Abstract] ( 40 ) HTML (32 KB) PDF (0 KB) ( 7 )

	122	Efficacy and safety of Cefotaxime Sodium in the adjuvant treatment of severe community-acquired pneumonia in children
		LI Jin-wu
		Objective To study the efficacy and safety of Cefotaxime Sodium in the adjuvant treatment of severe community acquired pneumonia(CAP)in children.Methods Altogether 78 children with severe CAP treated in Huanggang Maternity and Children Health Care Hospital from June 2019 to December 2020 were selected as the research object,and they were divided into the control group(39 cases)and the observation group(39 cases)according to random number table method.The control group was treated with routine treatment,and the observation group was treated with Cefotaxime Sodium on the basis of the control group.The improvement time of clinical symptoms,serum inflammatory factors,immune function indexes,clinical efficacy and adverse reactions were compared between the two groups.Results The improvement time of fever,cough and pulmonary rale in the observation group were shorter than those in the control group,with statistically significant differences (P＜0.05).After treatment,the levels of serum C-reactive protein(CRP),serum procalcitonin(PCT),interleukin(IL)-6 and leukocyte clusters of differentiation 8+(CD8+)in the observation group were lower than those in the control group,the levels of CD3+,CD4+and the total clinical effective rate after treatment in the observation group were higher than those in the control group,with statistically significant differences(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Application of Cefotaxime Sodium in the adjuvant treatment of children with severe CAP can promote the improvement of clinical efficacy,help to improve clinical symptoms and reduce inflammatory reaction,with high drug safety.
		2021 Vol. 28 (33): 122-125 [Abstract] ( 48 ) HTML (35 KB) PDF (0 KB) ( 7 )

	126	Effect of oblique-slung fixing device used in the portable Doula instrument on labor analgesia effect,comfort and negative emotions of puerperae
		SHEN Duan-ping； TANG Qiu-xia
		Objective To investigate the effect of oblique-slung fixing device used in the portable Doula instrument on labor analgesia effect,comfort and negative emotions of puerperae.Methods A total of 100 pregnant women applying portable Doula instrument with rope fixing method in Ganzhou Municipal Hospital from June to Octomber 2020 were selected as control group,and 100 pregnant women who used the portable Doula instrument with oblique-slung fixing device between November 2020 and March 2021 were included as observation group.The two groups were compared in different stages of labor(first stage,second stage,third stage)pain numerical rating scale(NRS)score,peripartum comfort and postpartum 1 week negative emotion (Hamilton anxiety scale [HAMA],Hamilton depression scale[HAMD]).Results The NRS scores of the first,second and third stages of labor in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).The perinatal comfort of observation group was better than that of control group,the difference was statistically significant(P＜0.05).The scores of HAMA and HAMD in observation group at 1 week after labor were lower than those in control group,the differences were statistically significant(P＜0.05).Conclusion Portable Doula instrument with oblique-slung fixing device has an ideal labor analgesia effect,and can enhance the comfort and improve the negative emotions of puerperae.
		2021 Vol. 28 (33): 126-128 [Abstract] ( 33 ) HTML (32 KB) PDF (0 KB) ( 8 )

	129	Influence of Leuprorelin on serum insulin-like growth factor 1,vascular endothelial growth factor and sex hormone levels in patients with uterine fibroids
		PENG Can； FU Chun-hua； OU Shui-ying
		Objective To investigate the influence of Leuprorelin on serum insulin-like growth factor 1(IGF-1),vascular endothelial growth factor(VEGF)and sex hormone levels in patients with uterine fibroids.Methods A total of 70 patients with uterine fibroids treated in Huiyang Sanhe Hospital from January 2019 to January 2020 were selected as the research subjects.According to random number table method,they were divided into the observation group(35 cases)and the control group (35 cases).The observation group was treated with Leuprorelin,and the control group was treated with Mifepristone.The levels of hypersensitive C-reactive protein(hs-CRP),IGF-1 and VEGF,the levels of sex hormones(estradiol[E2],progesterone[P],human chorionic gonadotropin[HCG],luteinizing hormone[LH],folliclestimulating hormone [FSH],luteinizing hormone/follicle-stimulating hormone [LH/FSH])and the incidence of adverse reactions between the two groups were compared.Results Before treatment,there were no significant differences in the levels of hs-CRP,IGF-1,VEGF between the two groups (P＞0.05).After treatment,the levels of hs-CRP,IGF-1,VEGF in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).Before treatment,there were no statistical significance in the levels of E2,P,HCG,LH,FSH,LH/FSH between the two groups (P＞0.05).After treatment,the levels of E2,FSH and P in the observation group were higher than those in the control group,and the levels of HCG,LH and LH/FSH in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).After treatment,the total incidence of adverse drug reactions in the observation group(5.71%)was lower than that in the control group(28.57%),with statistical significance(P＜0.05).Conclusion Leuprorelin is effective in the treatment of uterine fibroids,which can effectively improve the serum level,stabilize the level of sex hormone,and the drug is safe.It is worthy of clinical promotion and application.
		2021 Vol. 28 (33): 129-131转135 [Abstract] ( 39 ) HTML (30 KB) PDF (0 KB) ( 7 )

	132	Effect of biofeedback electrical stimulation+pelvic floor muscle rehabilitation training in the treatment of postpartum pelvic floor dysfunction
		LIAO Li
		Objective To explore the effect of biofeedback electrical stimulation+pelvic floor muscle rehabilitation training in the treatment of postpartum pelvic floor dysfunction(PFD).Methods A total of 100 patients with postpartum PFD who were admitted to the Department of Gynecology and Pediatrics,Putian Branch of No.900 Hospital from May 2019 to May 2020 were selected as the study subjects.They were divided into a control group (50 cases)and an intervention group (50 cases)by random lot drawing method.The control group was given biofeedback+electrical stimulation for treatment,and the intervention group was further given pelvic floor muscle rehabilitation training based on the treatment of biofeedback+electrical stimulation.The strength of pelvic floor muscles,muscle voltage and treatment satisfaction after treatment were compared between the two groups.Results After treatment,the slow muscle strength and fast muscle strength of the pelvic floor muscle in the intervention group were higher than those in the control group,and the resting muscle strength was lower than that in the control group,and the differences were statistically significant(P＜0.05).The maximum muscle voltage and the muscle voltage of continuous contraction for 60 s of pelvic floor muscle in the intervention group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The total satisfaction rate of the intervention group was 98.00%,higher than 80.00% of the control group,and the difference was statistically significant(P＜0.05).Conclusion Biofeedback electrical stimulation+pelvic floor muscle rehabilitation training for the PFD patients has a significant therapeutic effect,which can effectively enhance the strength of the patient′s pelvic floor muscles,improve the pelvic floor muscle voltage,promote its recovery,and obtain a higher treatment satisfaction.Therefore,it is worthy of popularization and application.
		2021 Vol. 28 (33): 132-135 [Abstract] ( 33 ) HTML (34 KB) PDF (0 KB) ( 7 )

	136	Clinical effect of auditory hypersensitivity training combined with Mouse Nerve Growth Factor on autistic children
		WU Hong-xing；ZHANG Chun-tao； XIE Xiao-zhen；WANG Xue-ying；LI Pei-shan；LUO Bi-qing
		Objective To investigate the clinical effect of auditory hypersensitivity training combined with Mouse Nerve Growth Factor(mNGF)on autistic children.Methods A total of 201 children with autism admitted to Zhongshan People′s Hospital in Guangdong Province from June 2018 to December 2020 were selected as the research subjects.They were divided into a control group(98 cases)and an observation group(98 cases)by the random number table method.Patients in the control group were treated with mNGF injection,and patients in the observation group were treated with mNGF combined with auditory hypersensitivity training.Before intervention and 8 weeks after intervention,the two groups were compared of the scores of the autism behavior checklist(ABC),childhood autism rating scale(CARS)and autism rating scale.Single factor analysis was used to analyze the effect of intervention on children with autism in the observation group.The difference of total autism score before and after intervention was taken as the dependent variable,and gender,only child or not,and place of residence were taken as the independent variables for multi-factor regression analysis.Results The ABC scores and the CARS scores in the two groups were lower than those before intervention,with statistical significances(P＜0.05).The ABC score and the CARS score of the observation group were lower than those of the control group after intervention,with statistical significances(P＜0.05).The autism scores of each item in both groups after intervention were higher than those before intervention,with statistical significances(P＜0.05).The autism scores of each item of the observation group were higher than those of the control group after intervention,with statistical significances(P＜0.05).Univariate analysis showed that there were statistically significant differences in total autism score difference before and after intervention among children of different genders,only children or not,and children of different places of residence in the observation group (P＜0.05).The results of multivariate analysis showed that place of residence and only child affected the intervention effect of autistic children in the observation group (P＜0.05).Conclusion mNGF combined with auditory hypersensitivity training can significantly improve the therapeutic effect and various abilities of children with autism,and effect of mNGF combined with auditory hypersensitivity training of children with autism was also influenced by the place of residence and the only child or not affect the intervention effect.
		2021 Vol. 28 (33): 136-140 [Abstract] ( 43 ) HTML (39 KB) PDF (0 KB) ( 8 )

	141	Application effect of surgery of conjoint fascia sheath suspension and frontalis muscle flap suspension in surgery of severe ptosis
		AN Yan； JIANG Yan-hua▲
		Objective To explore the effect of conjoint fascia sheath(CFS)suspension and frontalis muscle flap suspension in the surgery of severe ptosis.Methods A total of 78 patients with severe ptosis who were admitted to the Ophthalmic Plastic Surgery Center,Shenyang Fourth People′s Hospital from June 2018 to December 2019 were selected as the research subjects,and were divided into the observation group (39 cases)and the control group (39 cases)by the random number table method.The observation group was treated with CFS suspension combined with levator palpebrae superioris muscle shortening,while the control group was treated with frontalis muscle flap suspension.The patients were followed up for 6 months after surgery,and the cure rate and the incidence of complications were compared between the two groups.Results The surgical cure rate of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).The incidence of surgical complications in the observation group was lower than that in the control group,and the difference was statistically significant(P＜0.05).Conclusion Compared with frontalis muscle flap suspension,CFS suspension combined with levator palpebrae superioris muscle shortening to correct severe ptosis is a safe and effective operation,with high patient satisfaction and few complications in clinical practice,which is worthy of clinical promotion.
		2021 Vol. 28 (33): 141-144 [Abstract] ( 29 ) HTML (35 KB) PDF (0 KB) ( 5 )

	145	Clinical effect of Pranoprofen Eye Drops combined with Olopatadine Hydrochloride Eye Drops in the treatment of patients with allergic conjunctivitis
		ZHANG Jing； XIE Hong
		Objective To explore the clinical effect of Pranoprofen Eye Drops combined with Olopatadine Hydrochloride Eye Drops in the treatment of patients with allergic conjunctivitis(AC).Methods A total of 126 AC patients(126 affected eyes)admitted to the Department of Ophthalmology,Hubei Hospital of Integrated Traditional Chinese and Western Medicine from January to December 2020 were selected and divided into the control groups(63 affected eyes)and the observation groups (63 affected eyes)according to the random number table method.The control group was given Olopatadine Hydrochloride Eye Drops,and on this basis,the observation group was given Pranoprofen Eye Drops.The treatment effect,immune function,tear break-up time(BUT),fluorscein staining(FL)score,histamine(HA),eosinophil cationic protein(ECP)levels and safety were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).Before treatment,there was no significant difference in immune function between the two groups(P＞0.05).After treatment,the levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin E(IgE)in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).Before treatment,there were no significant differences in BUT,FL scores,HA and ECP levels between the two groups(P＞0.05).After treatment,FL score,HA and ECP levels in the observation group were lower than those in the control group,BUT in the observation group was higher than that in the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion Pranoprofen Eye Drops combined with Olopatadine Hydrochloride Eye Drops are effective in treating patients with AC.They can improve the immune function of patients,adjust the level of inflammatory factors,repair corneal epithelium,maintain tear film stability,and have certain safety.
		2021 Vol. 28 (33): 145-148 [Abstract] ( 42 ) HTML (32 KB) PDF (0 KB) ( 12 )

	149	Application effect of traditional Chinese medicine Anshen pillow combined with self-management in improving negative emotions of patients with coronary heart disease
		LI Yi；ZHONG Wen； ZHANG Yan；WANG Ren-hong；TAN Gu-yu；ZHOU Liang；CHEN Lei
		Objective To explore the application effect of traditional Chinese medicine Anshen pillow combined with self-management in improving negative emotions of patients with coronary heart disease.Methods A total of 100 patients with coronary heart disease admitted to the Second Affiliated Hospital of Nanchang University from January to December 2019 were selected and divided into the control group(50 cases)and the study group(50 cases)according to the operation sequence.The patients in the control group were given conventional nursing methods,while the patients in the study group were given conventional nursing+traditional Chinese medicine Anshen pillow combined with selfmanagement methods.The negative emotions (Hamilton depression scale [HADA],Hamilton anxiety scale[HAMA]),Seattle angina questionnaire(SAQ)scale,self-management score and sleep quality score(Pittsburgh sleep quality index[PQSI])were compared between the two groups.Results There were no significant differences in HADA,HAMA,SAQ,self-management ability and PQSI scores between the two groups before intervention (P＞0.05).After intervention,the scores of HADA,HAMA and PQSI in the study group were lower than those in the control group,while the scores of SAQ and self-management ability in the study group were higher than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Traditional Chinese medicine Anshen pillow combined with self-management is effective in improving the negative emotions of patients with coronary heart disease,which can obviously improve their symptoms and their sleep quality,enhance their self-management ability,which is worthy of clinical application and recommendation.
		2021 Vol. 28 (33): 149-151转155 [Abstract] ( 46 ) HTML (33 KB) PDF (0 KB) ( 7 )

	152	Application effect of Diyu Huaijiao Pills in patients after colorectal polyp operation under endoscopy
		YE Ting-ting；SHAO Yan-feng；WANG Jian-ping；WANG Qing-lian；CHEN Wen-hui；YU Li
		Objective To investigate the application effect of Diyu Huaijiao Pills in patients after colorectal polyp surgery under endoscopy. Methods A total of 100 patients who underwent endoscopic polypectomy in the Third People's Hospital of Fujian University of Traditional Chinese Medicine from July 2020 to June 2021 were selected and divided into control group(50 cases) and observation group(50 cases) by random number table method, the control group received routine care and treatment after operation, and the observation group took Diyu Huaijiao Pills orally on this basis. The postoperative complications, abdominal symptoms, bowel movements and satisfaction were compared between the two groups. Results The incidence of postoperative complications in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05); the postoperative abdominal symptoms in the observation group were lower than the control group, and the difference was statistically significant (P＜0.05); the observation group had defecation The situation was higher than that of the control group, and the difference was statistically significant (P<0.05); the satisfaction degree of the observation group was higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Diyu Huaijiao Pills can effectively reduce the incidence of postoperative complications and improve abdominal symptoms in patients with colorectal polyps, and it is worthy of clinical application.
		2021 Vol. 28 (33): 152-155 [Abstract] ( 52 ) HTML (1 KB) PDF (0 KB) ( 7 )

	156	Influence of medicine separated moxibustion combined with auricular application pressure on gastrointestinal function in hemodialysis patients
		QIN Yu-xia ；FU Chuan-cui；LIU Zhi-qiang
		Objective To explore the influence of medicine separated moxibustion combined with auricular application pressure on gastrointestinal function in hemodialysis patients.Methods A total of 80 hemodialysis patients with gastrointestinal dysfunction treated in Yidu Central Hospital from April to December 2020 were selected as the research object.They were divided into the traditional Chinese medicine group and the routine group according to random number table method,with 40 cases in each group.The routine group was treated with Mosapride,and the traditional Chinese medicine group was treated with medicine separated moxibustion combined with auricular application pressure.The clinical efficacy,the levels of serum albumin,hemoglobin,calcium,phosphorus,parathyroid hormone and the changes of human body composition before and after treatment were compared between the two groups.Results The total effective rate of the traditional Chinese medicine group was 92.5%,which was higher than 75.0% of the routine group,the difference was statistically significant(P＜0.05).After treatment,the levels of serum albumin,hemoglobin,body protein and body fat ratio in the traditional Chinese medicine group were higher than those in the routine group,the differences were statistically significant(P＜0.05).Conclusion Medicine separated moxibustion combined with auricular application pressure can enhance the gastrointestinal function in patients receiving hemodialysis and patients′nutrition.
		2021 Vol. 28 (33): 156-159 [Abstract] ( 40 ) HTML (34 KB) PDF (0 KB) ( 6 )

	160	Study on Jiawei Wendan Decoction in the treatment of senile hypertension and its influence on chemotactic factor CX3CL1
		YE Sui-lin ；CHENG Sha； YE Xi
		Objective To explore the treatment of senile hypertension with Jiawei Wendan Decoction and its influence on serum chemokine CX3CL1.Methods A total of 60 senile hypertensive patients admitted to Department of Cardiovascular Medicine,Affiliated Hospital of Traditional Chinese Medicine,Guangzhou Medical University from January 2019 to December 2020 were selected as the research objects,and were divided into treatment group (30 cases)and control group(30 cases)using the random number table method.All patients took Amlodipine Besylate Tablets after admission,the treatment group took Jiawei Wendan Decoction on this basis,and the control group took traditional Chinese medicine(TCM)placebo.The clinical efficacy,TCM syndrome scores before and after treatment,ambulatory blood pressure indicators,interventricular septal thickness (IVS)and carotid artery intima-media thickness (IMT),serum chemokine CX3CL1 levels and incidence of adverse cardiovascular events were compared between the two groups.Results The total effective rate of treatment in the treatment group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The TCM syndrome scores of the treatment group after treatment were lower than those in the control group,and the difference was statistically significant(P＜0.05).There were no significant differences in the 24 h average SBP and the 24 h average DBP,IVS,IMT and CX3CL1 between the two groups before treatment(P＞0.05）;after treatment,24 h average SBP,24 h average DBP,IVS,IMT and CX3CL1 levels of the two groups were lower than before treatment,and 24 h average SBP,24 h average DBP,IVS,IMT and CX3CL1 after treatment in the treatment group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Jiawei Wendan Decoction has obvious effects in the treatment of senile hypertensive patients.It can effectively improve various clinical symptoms,reduce blood pressure,and has a protective effect on promoting vascular endothelial function.It has high safety and is worthy of promotion.
		2021 Vol. 28 (33): 160-163 [Abstract] ( 37 ) HTML (34 KB) PDF (0 KB) ( 7 )

	164	Clinical value of tumor markers in lung cancer detection
		YAN Liang；LIU Yan
		Objective To explore the clinical value of tumor markers in the diagnosis of lung cancer.Methods A total of 120 suspected lung cancer patients admitted to Jiangxi Chest Hospital from December 2018 to December 2020 were selected as the research objects.All patients were tested for tumor markers,and pathological examination was used as the gold standard to compare the patient results.Results The levels of carcinoembryonic antigen (CEA),carbohydrate antigen 125(CA125),neuron specific enolase(NSE)and cytokeratin-19-fragment(CyFRA21-1)in lung cancer group were higher than those in non-lung cancer group,and the differences were statistically significant(P＜0.05).The specificity and accuracy of combined tumor marker detection were higher than those of CEA,NSE,Gyfra 21-1 single tumor marker detection,and the differences were statistically significant(P＜0.05).Conclusion It is of significant value to test tumor markers in lung cancer patients.
		2021 Vol. 28 (33): 164-166 [Abstract] ( 41 ) HTML (31 KB) PDF (0 KB) ( 7 )

	167	Value of serum tumor markers in diagnosis and histological classification of lung cancer
		WANG Chen-liang ；PENG Li-zi；ZHOU Bing
		Objective To study the diagnostic effect of serum tumor markers in the diagnosis of lung cancer and histopathological classification.Methods A total of 50 lung cancer patients admitted to the First People′s Hospital of Jiujiang City from September 2018 to September 2020 were selected as the observation group,and another 50 healthy individuals during the same period were selected as the control group.Serum tumor markers(carcino-embryonic antigen[CEA],carbohydrate antigen 125[CA125],carbohydrate antigen 199[CA199],neurospecific enolase[NSE]and cytokeratin 19 fragment[Cyfra21-1])were diagnosed in the two groups,and the diagnostic results were compared and analyzed.Results CEA,CA125,CA199,NSE and Cyfra21-1 in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).The sensitivity of CEA,CA125,CA199,NSE and Cyfra21-1 in adenocarcinoma was lower than that in squamous cell carcinoma and small cell lung cancer,and the difference was statistically significant(P＜0.05).There were significant differences in squamous cell carcinoma,adenocarcinoma and small cell carcinoma (P＜0.05).In the diagnosis of lung cancer,the sensitivity from high to low was CEA,CA125,CA199,NSE and Cyfra21-1,and the specificity from high to low was CEA,CA199,CA125,Cyfra21-1 and NSE.Conclusion The histopathological classification of lung cancer is related to the levels of CEA,CA125,CA199,NSE and Cyfra21-1.Its sensitivity and specificity for early diagnosis of lung cancer are relatively high.It can diagnose the disease early and improve the prognosis of patients.It is worthy of promotion.
		2021 Vol. 28 (33): 167-169转179 [Abstract] ( 46 ) HTML (32 KB) PDF (0 KB) ( 7 )

	170	Diagnostic and prognostic value of antinuclear antibody and alpha-fetoprotein in primary liver cancer
		ZHOU Xiao-juan； LIU Lian-bin； LIU Zhen-hua
		Objective To explore the value of anti-nuclear antibody(ANA)and alpha-fetoprotein(AFP)in the diagnosis and prognosis evaluation of primary liver cancer.Methods A total of 142 patients with liver disease admitted to Ganzhou Cancer Hospital from October 2016 to June 2018 were selected as the research subjects,and divided into primary liver cancer group(65 cases)and non-neoplastic liver disease group(77 cases)according to the pathological examination results.The levels of AFP and ANA were detected by electrochemiluminescence and ELISA,respectively.The levels of AFP and ANA were compared between the two groups,and the diagnostic value of each index alone and combined was calculated.The prognostic value of AFP and ANA expression levels in patients with primary liver cancer was analyzed.Results The levels of serum ANA and AFP in primary liver cancer group were higher than those in nontumor liver disease group,the differences were statistically significant(P＜0.05).The sensitivity,specificity and accuracy of ANA combined with AFP in the diagnosis of primary liver cancer were 84.62%,83.11% and 83.80%,respectively.Its sensitivity and accuracy were higher than those of single index,the differences were statistically significant(P＜0.05).At the end of follow-up,there were 41 cases with disease progression in the 65 patients with primary liver cancer.The levels of ANA and AFP in patients with disease progression were higher than those without disease progression,the differences were statistically significant(P＜0.05).ROC curve analysis showed that the AUC values of ANA,AFP and their combination for evaluating prognosis of patients with primary liver cancer were 0.759,0.789 and 0.892,respectively.AUC of combined detection was significantly higher than that of single index,the difference was statistically significant(P＜0.05).Conclusion ANA and AFP are abnormally expressed in primary liver cancer.The combined detection of the two indexes is of high value in the diagnosis and prognosis evaluation of primary liver cancer.
		2021 Vol. 28 (33): 170-172转187 [Abstract] ( 48 ) HTML (32 KB) PDF (0 KB) ( 7 )

	173	Clinical significance of abnormal prothrombin combined with alpha fetoprotein heterogeneity in hepatitis B related hepatocellular carcinoma
		QIU Yan； LAI Juan； ZHAN Kui
		Objective To study the clinical significance of abnormal prothrombin combined with alpha-fetoprotein(AFP)heterogeneity in hepatitis B related liver cancer.Methods From January 2019 to December 2020,20 outpatients and inpatients with liver cirrhosis in the Second People′s Hospital of Pingxiang City were selected as the liver cirrhosis group,and another 40 patients with hepatitis B related liver cancer admitted to hospital during the same period were selected as hepatitis B related liver cancer group.The levels of serum AFP,AFP heterogeneity and abnormal prothrombin were detected in all patients.The positive rates of serum AFP,AFP heterogeneity and other items,and the diagnostic value of single and combined detection were compared between hepatitis B related liver cancer group and liver cirrhosis group.Results The levels and positive rates of serum AFP,AFP heterogeneity and abnormal prothrombin in hepatitis B related liver cancer group were higher than those in liver cirrhosis group,the positive rate of abnormal prothrombin in hepatitis B related liver cancer group was higher than that of AFP,and the differences were statistically significant(P＜0.05).The specificity of the combined detection of the three was higher than that of abnormal prothrombin,and the sensitivity and accuracy were higher than that of AFP and AFP heterosomes alone,the differences were statistically significant(P＜0.05).Conclusion The levels and positive rate of serum AFP,AFP heterogeneity and abnormal prothrombin in patients with liver cancer are higher than those in patients with liver cirrhosis.The positive rate of abnormal prothrombin in hepatitis B related liver cancer group was higher than that of AFP.Combined detection of AFP heterogeneity and abnormal prothrombin can improve the positive rate of liver cancer screening,which is helpful for the early diagnosis of liver cancer.
		2021 Vol. 28 (33): 173-175 [Abstract] ( 39 ) HTML (30 KB) PDF (0 KB) ( 6 )

	176	Investigation and analysis of epidemiology and rehabilitation status of children with cerebral palsy
		LI Xi-ye；LI Meng-xiao；HUANG Bin-yang；YAO Yong-ping
		Objective To understand the quality of life of children with cerebral palsy and their families in Ngawa,and to provide a basis for the improvement and improvement of rehabilitation programs and family support services for children with cerebral palsy in later stage.Methods Children aged 2 to 12 from the rehabilitation Center of Tibetan Qiang Autonomous Prefecture of Ngawa in Sichuan province were selected from July to August 2020 to investigate the status of rehabilitation by questionnaire.The investigation content includes the pathogenesis,dysfunction and rehabilitation treatment of children with cerebral palsy.Results A total of 27 children with cerebral palsy were included.In terms of illness,severely restricted mobility accounted for 51.9%;assistive devices used in children with cerebral palsy accounted for 55.6%,and the ability to stand independently accounted for 55.6%.Patients with swallowing dysfunction accounted for 37.0%,children who had undergone surgery accounted for 5.4%.In terms of the rehabilitation status of children,20 cases received centralized rehabilitation treatment,accounting for 74.1%,1 case was community rehabilitation treatment,accounting for 3.7%.There are 20 cases of special financial assistance granted by the government,accounting for 74.1%,15 cases of receiving medical insurance or new rural cooperative medical insurance or part of reimbursement,accounting for 55.6%.Conclusion Affected by regional medical conditions,the rehabilitation awareness of children with cerebral palsy in this region and the utilization rate of rehabilitation AIDS need to be improved.
		2021 Vol. 28 (33): 176-179 [Abstract] ( 41 ) HTML (33 KB) PDF (0 KB) ( 7 )

	180	Investigation on the control rate and awareness rate of blood glucose,blood lipid and blood pressure of diabetic patients in Nanchang city
		DENG Bo；QI Yun-ting；WEN Fang；DENG Lu；XUAN Shan-shan；LI Jing；HU Yi；HU Ling
		Objective To investigate the status and gender difference of blood glucose,blood lipid and blood pressure control in diabetic patients in Nanchang city.Methods Patients with type 2 diabetes mellitus (T2DM)before entering the Nanchang single center of Metabolic Management Center(MMC)from June 2018 to December 2019 were selected as subjects.According to the comprehensive control objectives of Chinese T2DM Prevention and Treatment Guidelines(2020 edition),the control standards of blood glucose,blood pressure and blood lipids,knowledge of diabetes and gender differences were evaluated.Results A total of 1501 patients were enrolled,including 855 males(57%)and 646 females(43%).337 cases reached the standard of blood glucose,the rate of reaching the standard was 22.45%.The triglyceride,total cholesterol and low density lipoprotein cholesterol in the blood glucose conforming group were lower than those in the blood glucose conforming group,and the high density lipoprotein cholesterol in the blood glucose conforming group was higher than that in the blood glucose conforming group,the differences were statistically significant(P＜0.05).There was no significant difference between male and female blood glucose compliance rate (P＞0.05).The overall awareness rate of diabetes-related knowledge was 29.0%.The awareness rate of diabetes-related knowledge in females was higher than that in males,and the difference was statistically significant(P＜0.05).The prevalence of hypertension in diabetic patients was 53.1%,and the blood pressure control rate was 16.8%.The prevalence of dyslipidemia was 74.7%,and the rate of lipid control was 33.1%.There were no significant differences in the prevalence and control rate of hypertension and hyperlipidemia between males and females (P＞0.05).Conclusion T2DM patients have a low awareness rate of diabetes-related knowledge,and a low compliance rate of blood glucose,lipid and blood pressure control.It is hoped that MMC management can improve the compliance rate of common chronic diseases.
		2021 Vol. 28 (33): 180-183 [Abstract] ( 34 ) HTML (36 KB) PDF (0 KB) ( 7 )

	184	Spiritual health status and its influencing factors of patients with ovarian cancer after laparoscopic radical resection
		YANG Qin-fang； TENG Ting ；QI Li-hua
		Objective To analyze the spiritual health status of patients with ovarian cancer after laparoscopic radical resection and its influencing factors,so as to provide reference for the intervention and improvement of the spiritual health of patients after surgery.Methods A total of 60 patients with ovarian cancer who underwent laparoscopic radical resection in Shangrao Dongxin Fifth Hospital from January 2020 to December 2020 were selected as the research subjects.The patient′s general information and the Chinese version of the Functional Assessment of Chronic Illness Therapy Spiritual(FACIT-Sp-12)score,as well as the high-risk factors affecting the spiritual health of patients with ovarian cancer after laparoscopic radical resection were analyzed.Results The average FACIT-Sp-12 score of 60 patients with ovarian cancer after laparoscopic radical resection was(25.90±2.57)points.The spiritual health of 60 patients was divided into the poor spiritual health group (n=38)and the good spiritual health group (n=22)according to whether the FACIT-Sp-12 score was less than 24 points.The proportions of patients in the poor spiritual health group with age≥60 years,junior high school education and below,no religious beliefs,chemotherapy times≥2,and medical expenses payment methods were higher than those in the spiritual health group,and the differences were statistically significant(P＜0.05).Multivariate analysis showed that age≥60 years old,junior high school education level and below,and chemotherapy times≥2 times were influencing factors for poor spiritual health of patients with ovarian cancer after laparoscopic radical resection.Conclusion The spiritual health status of patients with ovarian cancer after laparoscopic radical resection is at a lower-middle level.Among them,age≥60 years old,junior high school education and below,and frequency of chemotherapy≥2 are influencing factors the poor spiritual health of patients with ovarian cancer after laparoscopic radical resection.
		2021 Vol. 28 (33): 184-187 [Abstract] ( 42 ) HTML (31 KB) PDF (0 KB) ( 6 )

	188	Effect of traditional Chinese medicine constitution type on sleep quality of night nurses
		WANG Hai-yan；ZHANG Guang-qing；HUANG Qiu-ping
		Objective To investigate and analysis the influence of night shift nurses′traditional Chinese medicine physique type on sleep quality.Methods A total of 481 nurses in Guangdong Hospital of Traditional Chinese Medicine from June to December 2019 were selected by convenience sampling method,investigated by using the Chinese medicine physique scale and Pittsburgh sleep quality index(PSQI).Patients were divided into sleep disorder group(n=156)and normal sleep group (n=325)according to sleep quality scores,and the influence of traditional Chinese medicine constitution type on sleep quality was analyzed.Results The most common TCM physiques of 481 night shift nurses were Qi-stagnation(27.4%),damp-heat(17.9%),phlegm-damp(12.3%),and peaceful(10.6%),the sleep quality score was (7.11±4.80)points.Regression analysis results show that calmness is an independent protective factor for sleep quality,while blood stasis,qi stagnation,phlegm-dampness,and dampness are independent risk factors for sleep quality(P＜0.05).Conclusion The sleep quality of night shift nurses is relatively poor.Constitution type is closely related to sleep quality in night shift nurses.Clinical nursing managers can design nursing management strategies according to constitution types to promote their sleep quality and physical and mental health.
		2021 Vol. 28 (33): 188-191 [Abstract] ( 37 ) HTML (33 KB) PDF (0 KB) ( 8 )

	192	Construction practice of emergency system in tertiary general hospital
		LI Ji-feng ；LIU Sheng-cai；CHEN Yu-yang ；CHEN Shao-wan ；HUANG Wen-li
		With the development of social economy and changes in the global environment,various emergencies emerge in an endless stream,and new major infectious diseases keep emerging,causing huge losses and threats to the social economy and people′s health,and posing a severe challenge to the country′s emergency management system,medical rescue and disease prevention and control.In the face of every emergency,tertiary general hospitals play an important role,so it is imperative to build an efficient and rapid emergency response and treatment system to cope with the medical rescue needs of disasters,accidents and public health emergencies.This paper shares the experience of the Second People′s Hospital of Shantou City as an emergency hospital in exploring emergency medical rescue and constructing emergency response system,hoping to provide reference for other hospitals′emergency rescue construction.
		2021 Vol. 28 (33): 192-195 [Abstract] ( 33 ) HTML (38 KB) PDF (0 KB) ( 9 )

	196	Effect of practice standard of infusion therapy in neonatal intensive care unit
	Effect of practice standard of infusion therapy in neonatal intensive care unit [J]. 中国当代医药, 2021,28(33): 196-199转203')" href="#">	ZHANG Jin-xia；YANG Yu-min；YANG Ying；CHEN Chao；HUA Jing
		Objective To explore the effect of the Infusion Therapy Standards of Practice formulated by the Infusion Nursing Society(INS)in 2016 in neonatal intensive care unit(NICU).Methods A total of 568 children treated with infusion therapy from December 2019 to February 2020 in NICU ward of Hengyang Maternal and Child Health Hospital were selected as the control group,and 407 children treated with infusion therapy from September 2020 to November 2020 were selected as the observation group.The control group received conventional infusion treatment,and the observation group received infusion treatment according to the Infusion Therapy Standards of Practice.The infusion site,application,fixation and maintenance,catheter maintenance,infusion connection,puncture tools and complications were compared between the two groups.Results Comparison of infusion sites between the two groups showed statistical significance(P＜0.05).The selection rate of the back of hand,armpit and forearm was higher in the observation group,and the selection rate of the back of hand,joint and armpit was higher in the control group.The qualified rates of application fixation and maintenance,catheter maintenance and infusion connection in the observation group were higher than those in the control group,the differences were statistically significant(P＜0.05).The total incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P＜0.05).There was no significant difference in the types of intravenous infusion tools between the two groups(P＞0.05).Conclusion Through the Infusion Therapy Standards of Practice,to carry out the quality control of intravenous treatment process,can promote the NICU nurses to reasonably select the puncture site,standardize the fixation and maintenance of the puncture site,so as to reduce the occurrence of neonatal intravenous infusion related complications,improve the quality of neonatal intravenous treatment nursing,and ensure the safety of neonatal intravenous treatment nursing.
		2021 Vol. 28 (33): 196-199转203 [Abstract] ( 26 ) HTML (40 KB) PDF (0 KB) ( 9 )

	200	Discussion on the function of professional management assistant under the traditional Chinese medicine multi-disciplinary treatment management mode
		WU Li-rong； FEI Yang-hua
		With the implementation of the new medical reform,traditional Chinese medicine （TCM）has a huge space for rapid development with its own advantages.Through the analysis of the development history and current situation of TCM,this paper found that the research on the characteristic service of TCM in prefecture-level city general hospitals is mostly from the view of diseases rather than the diagnosis and treatment model of TCM.Therefore,this paper puts forward the construction of TCM multi-disciplinary treatment(MDT)management mode,and discusses the necessity and feasibility of the construction,investigate the functions of professional management assistant under this model.And it can provide references for prefecture-level city general hospitals to develop TCM,adapt to the requirements of medical reform,and carry out integrated traditional Chinese and Western medicine.
		2021 Vol. 28 (33): 200-203 [Abstract] ( 40 ) HTML (31 KB) PDF (0 KB) ( 6 )

	204	Application of cooperative learning combined with problem-based teaching model in clinical internship in department of gastrointestinal surgery
		WANG Zhen； CHEN Jun-qiang
		Objective To evaluate the effect of cooperative learning combined with problem-based learning(PBL)teaching model in the internship teaching in the department of gastrointestinal surgery.Methods Altogether 97 clinical undergraduates who were interned in the First Affiliated Hospital of Guangxi Medical University from September 2020 to January 2021 were selected as subjects.According to the simple randomization method,they were divided into experimental group (using cooperative learning combined with PBL teaching,49 students)and control group (using conventional teaching mode,48 students).The test scores and teaching effect of the two groups were compared.Results The test results of theoretical knowledge and clinical case analysis ability of the experimental group were higher than those of the control group,the differences were statistically significant(P＜0.05).Students in the experimental group had better feedback on teachers′teaching ability,curriculum content and arrangement,theoretical knowledge mastery,clinical thinking cultivation,stimulating learning interest,cultivation of independent learning ability,teamwork awareness and improvement of communication ability with patients than those in the control group,with statistical significances(P＜0.05).Conclusion Cooperative learning combined with PBL teaching mode can improve the internship effect of gastrointestinal surgery for medical students,and is recognized by the students.
		2021 Vol. 28 (33): 204-207 [Abstract] ( 38 ) HTML (33 KB) PDF (0 KB) ( 8 )

	208	Study on the effect of peer education program on blood glucose fluctuation in patients with initial insulin therapy
		ZHANG Yong-hong；CHENG Wei； XU Ying
		Objective To explore the effect of peer education program in patients with initial insulin therapy.Methods Eighty-five diabetic patients who received initial insulin treatment at the Fourth Affiliated Hospital of Nanchang University from April 2019 to December 2020 were selected as the research subjects,and they were divided into a control group(routine care,42 cases)using the random number table method.Compared with the observation group(peer education,43 cases),both groups were continuously intervened for 3 months to observe the treatment compliance of the two groups,and the blood glucose levels and self-management levels of the two groups before and after the intervention for 3 months were compared.Results After 3 months of intervention,the total treatment compliance of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).After 3 months of intervention,the treatment compliance of observation group was higher than control group,the difference was statistically significant(P＜0.05).Before intervention,there were no significant differences in fasting blood glucose and 2 h postprandial blood glucose between the two groups (P＞0.05).After 3 months of intervention,the fasting blood glucose and 2 h postprandial blood glucose in the observation group were lower than those in the control group,the differences were statistically significant(P＜0.05).Before intervention,there was no significant difference in self-management level between the two groups (P＞0.05).After 3 months of intervention,the self-management level of the observation group was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion The peer education program can improve treatment compliance and self-management level of patients with initial insulin therapy,and reduce blood glucose levels.
		2021 Vol. 28 (33): 208-210转215 [Abstract] ( 37 ) HTML (32 KB) PDF (0 KB) ( 6 )

	211	Effect of application of comprehensive training mode in the training of geriatric specialty nurses
		WU Yuan-rong；CHEN Miao-hong；SHEN Man-xuan；LIN Zhe-xin；FANG Hai-yun
		Objective To explore the effect of application of comprehensive training mode in the training of geriatric specialty nurses.Methods A total of 159 clinical nurses from 148 hospitals in Guangdong Province,Jiangxi Province,Xinjiang Uygur Autonomous Region,Guizhou Province,Guangxi Zhuang Autonomous Region,Sichuan Province and Hainan Province from June 2018 to June 2020 were selected as the subjects of the study,and the comprehensive training model was adopted for training.The differences of knowledge and skills,clinical teaching ability,organizational ability and scientific research ability of students before and after training were compared,and the training satisfaction and scientific research and teaching results were investigated.Results After training,the self-ability evaluation scores of specialized knowledge and skills,clinical teaching ability,case management ability and scientific research ability were higher than before training,the differences were statistically significant(P＜0.05).The degree of satisfaction of theory courses and practice were 91.8% and 93.1%,respectively;during the internship,the students won 15 geriatric nursing scientific research projects and 13 geriatric nursing patents,and published 98 papers related to geriatric nursing.Conclusion The training mode,training content and effect of geriatric specialty nurses in Guangdong Province are recognized by the trainees.The students have made good achievements in the field of geriatric nursing after graduation.Therefore,the training mode is feasible and effective,which is worthy of popularization and application.
		2021 Vol. 28 (33): 211-215 [Abstract] ( 33 ) HTML (39 KB) PDF (0 KB) ( 6 )

	216	Exploration on the teaching reform of integrating humanistic spirit of Traditional Chinese Medicine into clinical medical education
		JING Su-hua；WANG Ming-jun
		Traditional Chinese medicine not only guides disease prevention and health care,but also enriches and nourishes the medical science of our country.As the only required professional course of Traditional Chinese Medicine in clinical medicine,Traditional Chinese Medicine can be used as an important starting point of humanistic education.This paper analyzes the current situation of clinical medical education,discusses the value and reform ways of integrating humanistic spirit of Traditional Chinese Medicine into clinical medical education by taking Traditional Chinese Medicine as the carrier,and explores the whole process education mode of "early cultivation-early experience-continuous practice" to shape humanistic spirit,so as to cultivate clinical medical professional education with humanistic spirit of traditional Chinese medicine,Actively promote the process of integration of professional education and humanistic spirit training.
		2021 Vol. 28 (33): 216-218转223 [Abstract] ( 49 ) HTML (32 KB) PDF (0 KB) ( 8 )

	219	Study on the application of PRECEDE-PROCEED model in family education of children with bronchial asthma
		SUN He；ZENG Li-zhong；WU Xing-feng
		Objective To explore the application effect of PRECEDE-PROCEED model in family education of children with bronchial asthma.Methods A total of 105 children with bronchial asthma and their parents in Zhuhai Center for Maternal and Child Health Care from January 2019 to December 2019 were selected as the research objects.According to the random number table method,they were divided into the control group(52 cases)and the observation group(53 cases).The control group adopted the routine nursing mode to implement health education,and the observation group adopted the PRECEDE-PROCEED mode to implement health education.The family members′disease management ability,children′s medication compliance,asthma control level and pulmonary function recovery were compared between the two groups.Results There were no significant differences in the scores of family members′disease management ability,children′s morisky medication adherence scale 8-item (MMAS-8),childhood asthma control test (C-ACT),the percentage of forced expiratory volume in the first second (FEV1%)and the percentage of peak expiratory flow rate in the expected value(PEF%)between the two groups before intervention(P＞0.05).After 3 and 6 months of intervention,the family members′disease management ability score,MMAS-8 score,C-ACT score,FEV1% and PEF% in the observation group were higher than those in the control group,and the scores of observation group after 6 months of intervention were higher than those after 3 months of intervention,and the differences were statistically significant (P＜0.05).Conclusion The PRECEDE-PROCEED model is beneficial to improve the disease management ability of the family members of children with bronchial asthma,improve the control level of children′s bronchial asthma and the compliance of taking medicine,and promote the recovery of the disease.
		2021 Vol. 28 (33): 219-223 [Abstract] ( 50 ) HTML (42 KB) PDF (0 KB) ( 64 )

	224	Application of game training method in the training of specialist nurses in department of emergency
		XIAO Liang-hua； ZHU Xiao-rong； CHEN Guo-hua； WANG Fang-fang； LUO Xia
		Objective To explore the application effect of game training method in the training of emergency nurses.Methods Eighty emergency nurses from July to December 2020 in the Fifth People′s Hospital of Ganzhou City were selected as the research objects and randomly divided into observation group (40 cases)and control group (40 cases).The control group was given routine training,and the observation group was given game training.The theoretical assessment,operation assessment and satisfaction of nurses in the two groups were compared.Results The total scores of theoretical examination,operation examination and satisfaction in the observation group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Conclusion The application of game training method in the training of specialist nurses in emergency department can significantly improve the mastery of theoretical knowledge,standardize the daily operation behavior and improve the satisfaction of nurses in this department.
		2021 Vol. 28 (33): 224-226转230 [Abstract] ( 36 ) HTML (33 KB) PDF (0 KB) ( 8 )

	227	Exploration and application of PBL online combined with simulated teaching method in critical care medical standardized resident training program during the COVID-19 epidemic
		ZHOU Xiao； DONG Lei；ZHAO Meng-ya； BAI Guo-qiang；DUAN Mei-li
		Objective To evaluate the application of PBL method online combined with simulation teaching during the COVID-19 epidemic in critical care medical standardized resident training program.Methods A total of 29 residents from Department of Critical Care Medicine of Beijing Friendship Hospital Affiliated to Capital Medical University from January to October 2020 were retrospectively selected as the experimental group,52 residents in the same hospital from January 2019 to October 2019 were selected as the control group.The experimental group received PBL online combined with simulation teaching while the control group received traditional teaching method.The results of theoretical examination,skill assessment and questionnaire survey of the two groups were compared,and the incidence of adverse events of the two groups was recorded for safety evaluation.Results The experimental group achieved higher score in theoretical examination,skill assessment,and the questionnaire results showed that the experimental group gave higher points in effectiveness of teaching methods,effectiveness of imparting knowledge,residents satisfaction,ability to analyze and explore problems,ability to accept knowledge,the initiative to participate in teaching,and the enthusiasm for learning,the differences were statistically significant(P＜0.05).There were 1 case of clinical adverse events in the experimental group and 3 cases in the control group.There was no significant difference in the incidence of adverse events between the two groups(P＞0.05).Conclusion During the COVID-19 epidemic,PBL online combined with simulated teaching can effectively improve the teaching quality in critical care medical standardized resident training program.
		2021 Vol. 28 (33): 227-230 [Abstract] ( 43 ) HTML (35 KB) PDF (0 KB) ( 7 )

	231	Effect of FeNO step-wise nursing intervention in reducing chronic obstructive pulmonary disease airway inflammation
		CHEN Shan-shan； YANG Lin-xia ；ZHOU Jing； LIU Zhi-qiang； LI Fang； CAI Hui
		Objective To explore the application effect of fractional exhaled nitric oxide (FeNO)step-by-step nursing intervention in reducing chronic obstructive pulmonary disease (COPD)airway inflammation.Methods A total of 60 COPD patients admitted to the First People′s Hospital of Jiujiang City from February 2019 to February 2021 were selected and divided into two groups according to the random number table method,30 cases in each group.The control group adopted conventional FeNO nursing measures,and the observation group adopted individualized stepwise nursing intervention according to the FeNO detection status and result data.Intervention for 3 months.The comfort level,FeNO value,lung function,self-care ability and nursing satisfaction were compared between the two groups.Results The self-care ability scale (ESCA)score and comfort level of the observation group were higher than those of the control group,FeNO after intervention was lower than that of the control group,the level of forced expiratory volume in 1 second (FEV1)was higher than that of the control group,the nursing total satisfaction was 93.33.%,higher than 73.33% in the control group,the differences were statistically significant(P＜0.05）.Conclusion FeNO stepped nursing intervention can improve the comfort and self-care ability of COPD patients,improve the lung function of patients,and increase nursing satisfaction.
		2021 Vol. 28 (33): 231-233 [Abstract] ( 42 ) HTML (31 KB) PDF (0 KB) ( 7 )

	234	Research on diversified nursing intervention in physical restraint of ICU patients
		LI Xin；FANG Liang；LI Dong-ying；HU Xiao-ying
		Objective To explore the effect of multiple nursing intervention on physical restraint ofintensive care unit(ICU)patients.Methods A total of 88 critically ill patients admitted to the Second Affiliated Hospital of Nanchang University from July to December 2019 were selected as the research subjects.According to the random number table method,they were divided into the control group (44 cases)and the experimental group (44 cases).The control group received conventional physical restraint nursing,and the experimental group received diversified nursing.The rate of physical restraint and the incidence of delirium were compared between the two groups,and the time of restraint was recorded to investigate patients′satisfaction with nursing.Results The rates of physical restraint and delirium in the experimental group were 45.45% and 4.55%,both lower than those in the control group of(72.73% and 20.45%),and the differences were statistically significant(P＜0.05).The constraint time of the experimental group was(80.87±7.23)h,shorter than that of the control group of(158.94±10.26)h,and the nursing satisfaction score was(88.76±5.28)points,which was higher than that of the control group of(80.97±5.26)points,with statistical differences(P＜0.05).Conclusion Multiple nursing intervention can reduce the physical constraints of ICU patients,shorten the time of constraints,and promote the improvement of nursing satisfaction.
		2021 Vol. 28 (33): 234-236转240 [Abstract] ( 38 ) HTML (34 KB) PDF (0 KB) ( 8 )

	237	Application effect of special head scraping therapy in patients with insomnia of liver stagnation and fire
		XIAO Zi-wei；HE Ya-na
		Objective To explore the application effect of special head scraping therapy in insomnia patients with liver stagnation and fire.Methods From November 2020 to May 2021 in the First Affiliated Hospital of Hu′nan University of Chinese Medicine,60 Patients with insomnia of liver stagnation and fire type were selected and divided into the control group(30 cases)and the observation group(30 cases)by random number table method.On the basis of conventional nursing,the control group was treated with traditional head scraping therapy,and the observation group was treated with special head scraping therapy.Pittsburgh sleep quality index (PSQI)score,traditional Chinese medicine(TCM)symptom score and self-rating anxiety scale (SAS)score were compared between the two groups.Results PSQI score，TCM symptom and SAS score of two groups after treatment were lower than before,and PSQI score,TCM symptom and SAS score of the observation group were lower than those of the control group,the differences were statistically significant(P＜0.05).Conclusion Special head scraping therapy can effectively improve the sleep quality of patients with liver stagnation and fire type insomnia,reduce the symptoms of TCM,reduce anxiety and the effect is more significant than the traditional head scraping.
		2021 Vol. 28 (33): 237-240 [Abstract] ( 37 ) HTML (35 KB) PDF (0 KB) ( 6 )

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