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| Value of serum tumor markers in diagnosis and histological classification of lung cancer |
| WANG Chen-liang PENG Li-zi ZHOU Bing▲ |
| Department of Pathology,the First People′s Hospital of Jiujiang City,Jiangxi Province,Jiujiang 332000,China |
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Abstract Objective To study the diagnostic effect of serum tumor markers in the diagnosis of lung cancer and histopathological classification.Methods A total of 50 lung cancer patients admitted to the First People′s Hospital of Jiujiang City from September 2018 to September 2020 were selected as the observation group,and another 50 healthy individuals during the same period were selected as the control group.Serum tumor markers(carcino-embryonic antigen[CEA],carbohydrate antigen 125[CA125],carbohydrate antigen 199[CA199],neurospecific enolase[NSE]and cytokeratin 19 fragment[Cyfra21-1])were diagnosed in the two groups,and the diagnostic results were compared and analyzed.Results CEA,CA125,CA199,NSE and Cyfra21-1 in observation group were higher than those in control group,and the differences were statistically significant(P＜0.05).The sensitivity of CEA,CA125,CA199,NSE and Cyfra21-1 in adenocarcinoma was lower than that in squamous cell carcinoma and small cell lung cancer,and the difference was statistically significant(P＜0.05).There were significant differences in squamous cell carcinoma,adenocarcinoma and small cell carcinoma (P＜0.05).In the diagnosis of lung cancer,the sensitivity from high to low was CEA,CA125,CA199,NSE and Cyfra21-1,and the specificity from high to low was CEA,CA199,CA125,Cyfra21-1 and NSE.Conclusion The histopathological classification of lung cancer is related to the levels of CEA,CA125,CA199,NSE and Cyfra21-1.Its sensitivity and specificity for early diagnosis of lung cancer are relatively high.It can diagnose the disease early and improve the prognosis of patients.It is worthy of promotion.
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