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| Study on Jiawei Wendan Decoction in the treatment of senile hypertension and its influence on chemotactic factor CX3CL1 |
| YE Sui-lin CHENG Sha YE Xi |
| Department of Cardiology,Affiliated Hospital of Traditional Chinese Medicine,Guangzhou Medical University,Guangdong Province,Guangzhou 510000,China |
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Abstract Objective To explore the treatment of senile hypertension with Jiawei Wendan Decoction and its influence on serum chemokine CX3CL1.Methods A total of 60 senile hypertensive patients admitted to Department of Cardiovascular Medicine,Affiliated Hospital of Traditional Chinese Medicine,Guangzhou Medical University from January 2019 to December 2020 were selected as the research objects,and were divided into treatment group (30 cases)and control group(30 cases)using the random number table method.All patients took Amlodipine Besylate Tablets after admission,the treatment group took Jiawei Wendan Decoction on this basis,and the control group took traditional Chinese medicine(TCM)placebo.The clinical efficacy,TCM syndrome scores before and after treatment,ambulatory blood pressure indicators,interventricular septal thickness (IVS)and carotid artery intima-media thickness (IMT),serum chemokine CX3CL1 levels and incidence of adverse cardiovascular events were compared between the two groups.Results The total effective rate of treatment in the treatment group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The TCM syndrome scores of the treatment group after treatment were lower than those in the control group,and the difference was statistically significant(P＜0.05).There were no significant differences in the 24 h average SBP and the 24 h average DBP,IVS,IMT and CX3CL1 between the two groups before treatment(P＞0.05）;after treatment,24 h average SBP,24 h average DBP,IVS,IMT and CX3CL1 levels of the two groups were lower than before treatment,and 24 h average SBP,24 h average DBP,IVS,IMT and CX3CL1 after treatment in the treatment group were lower than those in the control group,the differences were statistically significant(P＜0.05).Conclusion Jiawei Wendan Decoction has obvious effects in the treatment of senile hypertensive patients.It can effectively improve various clinical symptoms,reduce blood pressure,and has a protective effect on promoting vascular endothelial function.It has high safety and is worthy of promotion.
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