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| Analysis of related factors of stillbirth in pregnant women with HELLP syndrome |
| LIU Wei ZHU Yi-rong CHEN Jin▲ |
| The 2ndward of gynecology,Jiangxi Maternal and Child Health Hospital,Jiangxi Province,Nanchang 330000,China |
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Abstract Objective To investigate the related factors of stillbirth in pregnant women with HELLP syndrome.Methods A total of 84 cases of HELLP syndrome admitted into Jiangxi Maternal and Child Health Hospital from January 2015 to March 2021 were selected as the research objects,and 19 cases of neonatal death were defined as the observation group,while 65 cases of neonatal survival were defined as the control group.The logistic regression model was used to analyze the correlation between 21 clinical data indexes and stillbirth.Results The singe-factor analysis showed that the differences were not statistically significant in the age,menarche age,gravidity,serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),lactate dehydrogenase(LDH),alkaline phosphatase(ALP),γ-glutamyl transpeptidase(GGT)and prealbumin(PA),plasma prothrombin time(PT)and activated partial thromboplastin time(APTT),the incidence rates of premature delivery,fetal distress and oligohydramnios between the 2 groups(P＞0.05).The parity,systolic blood pressure(SBP),diastolic blood pressure(DBP),serum total bilirubin(TBil)of the observation group were higher than those of the control group,while the whole blood hemoglobin(Hb),platelet(PLT)and plasma fibrinogen(Fbg)were lower than those of the control group,the differences were statistically significant(P＜0.05).The multivariate logistic analysis showed that the SBP,DBP and serum TBil were independent risk factors of stillbirth in pregnant women with HELLP syndrome(P＜0.05),while the whole blood Hb,PLT and plasma Fbg were independent protective factors(P＜0.05).Conclusion There are many related factors of stillbirth in women with HELLP syndrome,and some clinical intervention measures can be targeted to improve the prognosis of pregnancy.
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