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2021 Vol. 28, No. 3
Published: 2021-01-28
 
 
4 Content determination of Atractylone, Atractylenolide Ⅰ, AtractylenolideⅡand Atractylenolide Ⅲin Atractylodis Macrocephalae Rhizoma stirfried with wheat bran from different habitats by high performance liquid chromatogram method
GAO Hong-ning； PAN Yu-rou；YIN Yi；YAN Guo-jun
 Objective To determine the content of Atractylone, Atractylenolide Ⅰ, Atractylenolide Ⅱand Atractylenolide Ⅲin Atractylodis Macrocephalae Rhizoma stir-fried with wheat bran from different habitats by high performance liquid chromatogram method, and to evaluate the quality of Atractylodis Macrocephalae Rhizoma stir-fried with wheat bran from different habitats. Methods The separation was performed on Dikma Diamonsil C8 (150 mm×4.6 mm, 5 μm)column with mobile phase consisted of water-acetonitrile (gradient elution) at the flow rate of 1.0 mL/min. The detection wavelength was set at 220 and 275 nm, the column temperature was 30℃and injection volume was 20 μL. Results Under the above chromatographic conditions, Atractylone, Atractylenolide Ⅰ, Atractylenolide Ⅱand Atractylenolide Ⅲ showed good linear relationship in the ranges of 47.600-142.800, 1.304-3.912, 1.126-3.378, 1.740-5.220 mg/L.The average recovery was 99.98%, 99.63%, 99.15%, 99.79%, respectively, and the relative standard deviation (RSD)was 0.03%, 1.70%, 1.57%, 1.10%, respectively. Conclusion This method is well-separated, specific, reproducible,simple and feasible. It can be used for the quality control method of Atractylodis Macrocephalae Rhizoma stir-fried with wheat bran. The result of determination shows that the content of the four components in Atractylodis Macrocephalae Rhizoma stir-fried with wheat bran from Zhejiang Pan′an is relatively higher.
2021 Vol. 28 (3): 4-7转12 [Abstract] ( 50 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
8 Study on safety dose and long-term toxicity of Gushuning Oral Liquid
WU Yong-mei；LIANG Zhi-min； WEI Yu-yan；QIN Liang
 Objective To observe the toxicity and safe dose of Gushuning Oral Liquid in rats after long-term repeated administration. Methods A total of 80 SD rats were selected and randomly divided into the low, middle, high dose group and the control group, 20 rats in each group. The low, middle and high dose groups were given Gushuning Oral Liquid 5.38, 10.76, 21.50 g medicine/(kg·d), respectively, and the control group were given equal volume distilled water, which were were gavaged for 12 weeks. During the period of administration, the general performance and toxic reaction of animals were observed daily, and recovered for 2 weeks after discontinuation. Routine toxicological observation and hematological and biochemical indexes were detected and compared. Results The weight gain of the low,medium and high dose groups were normal, and there was no significant difference compared with the control group (P＞0.05). There was no significant difference in hematological examination and blood biochemical examination between the low, medium and high dose groups and the control group (P＞0.05). In the histopathological examination of main organs,there was no obvious pathological change caused by drug toxicity. Conclusion The safe dose of Gushuning Oral Liquid to rats by gavage is 21.50 g medicine/(kg·d), which is 120 times of the daily dose of clinical adults. There is no toxic reaction after long-term repeated administration
2021 Vol. 28 (3): 8-12 [Abstract] ( 40 ) HTML (38 KB)  PDF  (0 KB)  ( 8 )
13 Clinical study of Runchang Decoction combined with Zhiyu Lotion in treating postoperative complications of mixed hemorrhoidal ligator
LIANG Wei-bing ；ZHOU Mei-fang ；HUANG Jin-hui ；YANG Ji-shui
Objective To explore the clinical effect of Runchang Decoction combined with Zhiyu Lotion in the treatment of postoperative complications of hemorrhoid ligation device modified internal injection. Methods A total of 200 patients with mixed hemorrhoids in the anorectal department of Kaiping Hospital of Traditional Chinese Medicine who were treated with a ligature modified internal ligation and internal injection from April 2018 to December 2019 were selected as the research objects, and they were divided into treatment group and control group by simple randomization method, with 100 cases in each group. The control group was treated with conventional treatment, and the treatment group was treated with Runchang Decoction combined with Zhiyu Lotion. The patients of two groups were compared with indicators of difficulty in defecation, pain at the surgical mouth, bleeding at the surgical mouth, edema at the surgical mouth, and excellent healing of the surgical mouth. Results In the treatment group, the cases of defecation difficulty, surgical mouth pain, surgical mouth bleeding, and surgical mouth edema were fewer than those in the control group, the differences were statistically significant (P＜0.05); the number of cases of excellent surgical healing in the treatment group was more than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Runchang Decoction combined with Hemorrhoid Lotion for the treatment of hemorrhoid ligation device after internal ligation and injection, it can better solve the problem of defecation in patients with hemorrhoid surgery, promote healing of the operation port, and thus promote the rehabilitation of patients and is worthy of cliniclal popularization and application.
2021 Vol. 28 (3): 13-16 [Abstract] ( 46 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
17 Effect analysis of clinical pharmacists participating in the pharmaceutical care of patients with long-term use of Glucocorticoids
ZENG Yan-cong ；HUANG Shuang-ying ；WU Di
objective To explore the role of clinical pharmacists in long-term treatment with Glucocorticoids patients through pharmaceutical care. Methods A total of 80 patients with nephrotic syndrome or systemic lupus erythematosus with long-term use of Glucocorticoids in Heyuan People′s Hospital from June 2018 to December 2019 were randomly selected. The patients with nephrotic syndrome and systemic lupus erythematosus in a 1∶1 way were divided into observation group (40 cases)and control group (40 cases) by random number table method. The control group received conventional treatment without clinical pharmaceutical care, and the observation group received conventional treatment with clinical pharmaceutical care, then the compliance, efficacy and adverse drug reactions between two groups were analyzed. Results Compared with the control group, the observation group had more understanding of the diseases,medicines and the drug compliance, the differences were statistically significant (P＜0.05). The renal function was improved, and the urinary protein decreased or negative urine patients were more than those in control group, the difference was statistically significant(P＜0.05). The main adverse drug reactions were Cushingoid features, with an incidence of more than 60%, but there was no significant difference between two groups (P＞0.05). However, the incidence of insomnia adverse reactions in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion The clinical pharmacists participated in the pharmaceutical care of patients with long-term use of Glucocorticoids could promote their understanding of the diseases and medicines, drug compliance,improve renal function and reduce the occurrence of adverse reactions such as insomnia.
2021 Vol. 28 (3): 17-20 [Abstract] ( 43 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
21 Significance of interleukin-6 distinguishing neonatal bloodstream infection caused by different bacteria and identification of blood culture contamination in the early stage
LIANG Jie-chang； XU Zhi-ming； LI Wan-mei ；YOU Fang-fang ；YE Mu-feng
 Objective To study the significance of serum interleukin-6 (IL-6) concentration in distinguishing neonatal bloodstream infection caused by different bacteria and identification of neonatal blood culture contamination in the early stage. Methods A total of 100 neonates with bloodstream infections admitted to Foshan Sanshui District People′s Hospital from January 2016 to June 2020 were selected as the observation group, and IL-6, procalcitonin (PCT) and Creactive protein were measured before the first day of treatment, and the blood culture was performed at the same time.According to the results of blood culture, 100 neonates with bloodstream infections were divided into Gram-negative(G-) bacterial group (27 cases) and Gram-positive (G+) bacterial group (73 cases), and according to the bacterial culture identification results, the G+ bacterial group was divided into Streptococcus group (26 cases) and coagulase-negative staphylococcus (CNS) group (47 cases). The concentrations of IL-6, PCT and CRP in serum of different bacterial groups were compared. And the value of IL-6 in identification of neonatal bloodstream infection caused by G- bacteria and G+bacteria was analyzed by the receiver operating characteristic (ROC) curve in the early stage. The blood culture contamination cases (63 cases) were selected as the control group at the corresponding period, and the value of IL-6 in identifying neonatal blood culture contamination was analyzed by the ROC curve. Results The serum concentrations of IL-6, PCT and CRP in G- bacteria group were 2033.0 (75.0-15 600.0) ng/L, 4.0 (0.58-18.99) ng/mL and 2.89 (0.51-21.40) μg/mL, respectively, and the concentrations of serum IL-6, PCT and CRP in G+bacteria group were 61.9 (26.1-1066.7) ng/L, 0.75 (0.26-2.70) ng/mL and 5.45 (0.82-11.86) μg/mL, respectively. There were statistically significant differences in IL-6 and PCT between the G- bacteria group and G+ bacteria group (P<0.05), but no statistically significant difference in CRP (P>0.05). The areas under the ROC curve of IL-6, PCT and CRP in distinguishing neonatal bloodstream infection caused by G- bacteria and G+ bacteria were 70.2%, 64.9% and 52.6%, respectively. The concentration of IL-6 in the Streptococcus group was higher than that in the CNS group, with statistically significant difference (P<0.05). The concentration of IL-6 in the observation group was higher than that in the control group, with statistically significant difference (P<0.05). The areas under ROC curve of IL-6, PCT and CRP in identifying neonatal blood culture contamination were 94.2%, 91.0% and 72.9%, respectively. Conclusion The concentration of IL-6 is valuable in the early identification of neonatal bloodstream infection caused by G- bacteria and G+ bacteria and in distinguishing neonatal blood culture contamination. Its effect is similar to PCT, but obviously superior to CRP. It can preliminarily distinguish early bloodstream infection caused by Streptococcus and CNS in G+ bacteria group. It is helpful for providing the basis for early treatment, which can save critical life.
2021 Vol. 28 (3): 21-24 [Abstract] ( 56 ) HTML (47 KB)  PDF  (0 KB)  ( 7 )
25 Research progress of non-small cell lung cancer with epidermal growth factor receptor mutation subtype and immune checkpoint blocking treatment
WU Liu-；LI Xiao-qiang
Lung cancer is a tumor-related disease with the highest incidence and mortality in the world. Non-small cell lung cancer (NSCLC) accounts for more than 80% of all lung cancer incidence rates and it has become the most concerned pathology type in the medical community. The International Association for the Study of Lung Cancer,American Thoracic Society and the European Respiratory Society (IASLC/ATS/ERS) first proposed the inextricable relationship between the pathological type of NSCLC and the mutant subtype of epidermal growth factor receptor (EGFR).NSCLC patients with different subtypes of EGFR mutations are sensitive to tyrosine kinase inhibitors (TKIs) that exist when receiving the same EGFR-TKI treatment, and the ideal therapeutic effect can be achieved in the early stage, but subsequent resistance often occurs, which makes treatment difficult. Due to the difference in efficacy, these patients also have occurred drug resistance after receiving the first-generation or second-generation EGFR-TKI. Even the use of Osimertinib (the third-generation EGFR-TKI) still cannot greatly meet the clinical treatment needs. Therefore,immune checkpoint inhibitors (ICIs) have become a treatment options that researchers are competing to explore. This article aims to provide a comprehensive overview for the research progress of EGFR mutation subtypes and immune checkpoint blocking treatment in advanced NSCLC.
2021 Vol. 28 (3): 25-28转33 [Abstract] ( 55 ) HTML (39 KB)  PDF  (0 KB)  ( 7 )
29 Research progress of PI3K/AKT signaling pathway and miR-203 in esophageal cancer
HUANG Hui；YIN Cai-qiao； CHEN Ting
Esophageal cancer is a malignant tumor originating from the esophageal epithelium with complex pathogenesis. In esophageal cancer, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) is one of the signaling pathways involved and often activated, its abnormal activation can promote the development of esophageal cancer. The miR-203 is a small non-coding RNA molecule generally 19-22 nucleotides in length, with abnormal expression in multiple malignant tissues. The miR-203 regulates gene expression at the post-transcriptional level by binding to the 3′UTR of the target gene, which is closely related to the tumor development process. In recent years, many literatures report that miR-203 can influence the expression of related genes through PI3K/AKT pathway, thus affecting the proliferation,apoptosis, invasion and migration of esophageal cancer cells, which is related to the progression of esophageal cancer,clinical treatment and prognosis of patients.
 
2021 Vol. 28 (3): 29-33 [Abstract] ( 52 ) HTML (44 KB)  PDF  (0 KB)  ( 5 )
34 Current status and research progress on medical image data augmentation technology
WANG Tian-ren； LI Yi-ning； WANG Hong-yi；KANG Jian；ZHAO Shuang； LIU An
Artificial intelligence-assisted medical image recognition diagnosis and treatment system has been used extensively. However, it is difficult to collect enough data to train the model under the current medical environment and social background. By data augmentation technology on processing existed samples, shrotage of data can be greatly eased. This article briefly summarized the common image augmentation techniques used in recent years. According to the number of samples processed, the existing data augmentation techniques are divided into two categories: singlesample data augmentation and multi-sample data augmentation. The former is further divided into pixel-level processing and overall horizontal geometric processing according to the different processing levels; while the latter mainly introduces the object of operation in the entire sample set represented by synthetic minority oversampling technique(SMOTE) algorithm and generative adversarial networks (GAN), and solves the imbalance by adjusting the sampling ratio. Additionally, this article also analyzed the advantages and disadvantages of each method, and summarized the performance and improvement of the above algorithms in recent years to provide new ideas for related practitioners.
2021 Vol. 28 (3): 34-37转44 [Abstract] ( 44 ) HTML (43 KB)  PDF  (0 KB)  ( 5 )
38 Effect of 308 nm excimer laser+Tacrolimus in the treatment of adult facial vitiligo
CHEN Jing ；LI Yu-liang ；PENG Sheng-zhi ；YI Sheng-gang； PENG Yan-ping； LIANG Qing
Objective To explore the effect of 308 nm excimer laser+Tacrolimus in the treatment of adult facial vitiligo.Methods Seventy patients with facial vitiligo admitted to Pingxiang People′s Hospital, Jiangxi Province from January 2018 to December 2019 were selected and divided into reference group (n=35) and research group (n=35) according to the random throwing method. The reference group was treated with 308 nm excimer laser irradiation, and the research group was treated with 308 nm excimer laser+Tacrolimus, the total effective rate, intercellular adhesion molecule-1 (ICAM-1), melanocyte stimulating hormone (α-MSH), interleukin-17 (IL-17) indexes levels before and after treatment and incidence of adverse reactions were compared between the two groups. Results The total effective rate of the research group was 94.29%, which was higher than 77.14% of the reference group, and the difference was statistically significant (P<0.05). There were no statistical differences in the levels of ICAM-1, α-MSH and IL-17 before treatment between the groups (P＞0.05). After treatment, ICAM-1 and IL-17 levels of the two groups were lower than those before treatment, and α-MSH level was higher than that before treatment; after treatment, the levels of ICAM-1 and IL-17 in the research group were lower than those in the reference group, and the level of α-MSH was higher than that in the reference group, the differences were statistically significant (P<0.05). The total adverse reaction rate in the research group was 11.43%, which was lower than that in the reference group (31.43%), the difference was statistically significant (P<0.05). Conclusion 308 nm excimer laser+Tacrolimus is effective in the treatment of adult facial vitiligo, and it has few adverse reactions, which has clinical promotion value.
2021 Vol. 28 (3): 38-40 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
41 Application of bone marrow infusion in rescuing patients with hemorrhagic shock after severe trauma
HE Si-xia ；LIANG Yong-sheng
 Objective To explore the application of bone marrow infusion in rescuing patients with hemorrhagic shock after severe trauma. Methods Retrospective analysis was performed on the clinical data of 80 patients with hemorrhagic shock from severe trauma treated in Huazhong University of Science and Technology Union Shenzhen Hospital from February 2018 to March 2020. Grouping according to admission time: 40 patients receiving routine peripheral venous infusion from February 2018 to February 2019 were included in the control group, and 40 patients receiving marrow cavity infusion from March 2019 to March 2020 were included in the study group. The treatment effect of the two groups was compared. Results The established passage time, first administration time, infusion time, blood pressure recovery time, and heart rate recovery time of the study group were shorter than those of the control group, and the infusion speed was faster than that of the control group, the differences were statistically significant (P<0.05); the success rate of one puncture in the study group was 97.50%, higher than 77.50% in the control group, the rescue success rate in the study group was 95.00%, higher than 77.50% in the control group, the differences were statistically significant(P<0.05). Conclusion In the rescue of patients with hemorrhagic shock after severe trauma, the application of bone marrow infusion can shorten the time of channel establishment, the time of the first administration, the time of infusion,the time of blood pressure recovery, improve the speed of infusion, and improve the success rate of the first puncture and the success rate of rescue.
2021 Vol. 28 (3): 41-44 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
45 Clinical study of Cinacalcet combined with high-throughput dialysis in the treatment of moderate to severe secondary hyperparathyroidism
YU Jian-gen；YANG Ai-hua；ZHANG Xiao-yun；SHEN Li-jun； ZHU Hua
Objective To study the clinical effect of Cinacalcet combined with high-throughput dialysis (HFD) in the treatment of moderate to severe secondary hyperparathyroidism （SHPT）. Methods Eighty patients with moderate to severe SHPT admitted to Hangzhou Xiaoshan District First People′s Hospital, Zhejiang Province from February 2018 to February 2020 were selected as the research objects. According to the random number table method, they were divided into the experimental group (40 cases) and the control group (40 cases). The control group used HFD, and the experimental group used Cinacalcet+ HFD. The thyroid length, width, thickness, volume and biochemical index levels of the two groups were compared. Results Before treatment, there were no significant differences in thyroid length, width,thickness and volume between the two groups (P＞0.05). After treatment, the thyroid length, width, thickness, and volume of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). The thyroid length, width, thickness, and volume of the experimental group after treatment were lower than those of the control group, and the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in the levels of biochemical indexes between the two groups (P＞0.05). The serum calcium content of the control group after treatment was higher than that before treatment, the serum calcium of the experimental group after treatment was lower than that before treatment, and the contents of phosphorus, immunoreactive parathyroid hormone (iPTH) and serum alkaline phosphatase (ALP) in two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). The serum calcium, phosphorus, iPTH and ALP contents of the experimental group after treatment were lower than those of the control group, and the differences were statistically significant (P<0.05). Conclusion Cinacalcet combined with HFD can more effectively control blood calcium, blood phosphorus, blood alkaline phosphatase, blood PTH levels and thyroid in patients with moderate to severe mineral and abnormal bone metabolism hyperplasia of parathyroid glands.
2021 Vol. 28 (3): 45-47 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
48 Cinical observation of oxygen therapy combined with bronchoscope alveolar lavage by nasal high flow humidifier in elderly patients with aspiration pneumonia and hypoxemia
YI Xiao-li； LI Yang-yang； YANG Jun-wei
Objective To investigate the clinical observation of transnasal high-flow humidifier oxygen therapy combined with bronchoscopy alveolar lavage (BAL) in elderly patients with aspiration pneumonia and hypoxemia. Methods The clinical data of 56 elderly patients with aspiration pneumonia and hypoxemia who were admitted to Taishan Hospital of Traditional Chinese Medicine from March 2019 to April 2020 were retrospectively analyzed. The patients who were treated with transnasal high-flow humidifier oxygen therapy combined with BAL treatment were returned for the treatment group (28 cases), patients who were routinely given basic treatments such as anti-infection, spasmolysis and asthma, cough and phlegm, oxygen inhalation, nutritional support, correction of acid-base imbalance, and maintenance of water and electrolyte disorders were classified as the control group (28 cases). The clinical efficacy and blood gas indexes, tracheal intubation rate, ICU occupancy rate, and acute physiology and chronic health score Ⅱ (APACHEⅡ)before and after 14 days of treatment were compared between the two groups. Results Compared with the control group,the total clinical effective rate of the treatment group was higher, and the difference was statistically significant (P<0.05). There were no significant differences in blood oxygen saturation (SaO2), partial pressure of oxygen (PaO2) and partial pressure of carbon dioxide (PaCO2) between the two groups before treatment (P＞0.05); after 14 days of treatment, the two groups′ SaO2 and PaO2 indicators increased, PaCO2 index decreased, and the treatment group changed greatly, the differences were statistically significant (P<0.05). The tracheal intubation rate and ICU occupancy rate in the treatment group were lower than those in the control group, and the differences were statistically significant(P<0.05). Compared with the APACHE Ⅱscores before treatment between the two groups, the difference was not statistically significant (P＞0.05). After 14 days of treatment, the APACHE Ⅱscores of the two groups decreased, and the scores of the treatment group were lower, the differences were statistically significant (P<0.05). Conclusion Elderly patients with aspiration pneumonia combined with hypoxemia have a significant effect of transnasal high-flow humidifier oxygen therapy combined with BAL treatment, which can improve clinical efficacy, improve blood gas indicators, reduce tracheal intubation rate and ICU occupancy rate, and reduce APACHE Ⅱscore. It is worthy of clinical promotion.
2021 Vol. 28 (3): 48-51 [Abstract] ( 37 ) HTML (40 KB)  PDF  (0 KB)  ( 5 )
52 Clinical effect of Hydroxychloroquine in the treatment of chronic actinic dermatitis
LIU Quan-wei
Objective To investigate the clinical effect of Hydroxychloroquine in the treatment of chronic actinic dermatitis. Methods A total of 100 patients with chronic actinic dermatitis admitted to Shenyang Seventh People′s Hospital, Liaoning Province from August 2018 to December 2019 were selected as the study objects. According to the random envelope method,they were divided into control group(50 cases)and experimental group(50 cases).The control group was treated with Tacrolimus Ointment and the experimental group was treated with Hydroxychloroquine. The symptoms and signs score,dermatology life quality index(DLQI)scale score,clinical treatment effect and adverse reactions were compared between the two groups. Results There was no significant difference the symptoms and signs score between the two groups before treatment (P＞0.05).The scores of symptoms and signs of the two groups after treatment were lower than those before treatment, the score of symptoms and signs in the experimental group was (3.45±0.55) points, lower than that in the control group of (5.65±0.80) points, the differences were statistically significant (P<0.05). There was no significant difference in DLQI score between the two groups before treatment (P＞0.05). The DLQI scores of the two groups after treatment were lower than those before treatment, the DLQI score of the experimental group was (6.50±0.80)points, lower than that of the control group of (9.55±0.90) points, the differences were statistically significant (P<0.05).The total effective rate of clinical treatment in the experimental group was 96.00%, higher than that of the control group 80.00%, the total incidence of adverse reactions in the experimental group was 2.00%, lower than that of the control group of 14.00%, the differences were statistically significant (P<0.05). Conclusion The clinical effect of Hydroxychloroquine in the treatment of chronic actinic dermatitis is accurate, it can improve the relevant clinical symptoms and signs, improve the quality of life of skin diseases, and the incidence of adverse reactions is low, it is worth clinical promotion.
2021 Vol. 28 (3): 52-54 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
55 Efficacy of transnasal high flow oxygen therapy on acute attack of bronchial asthma
NI Ying
Objective To investigate the efficacy of nasal high-flow oxygen therapy on acute exacerbation of bronchial asthma and its effect on prognosis. Methods A total of 64 patients with acute bronchial asthma and respiratory failure who were admitted to Jingzhou Chest Hospital, Hubei Province from Janurary 2018 to August 2019 were selected as the research subjects. According to random number table method, they were divided into observation group (n=32) and control group (n=32). The observation group received nasal high-flow oxygen therapy and the control group received conventional oxygen therapy, the differences in lung function, efficacy, and prognostic indexes between the two groups after treatment were compared. Results The observation group patients′ forced expiratory volume in one second, forced vital capacity and peak expiratory flow after treatment were higher than those in the control group, the differences were statistically significant (P<0.05). The total effective rate of the observation group (93.75%) was higher than that of the control group (81.25%), the difference was statistically significant (P<0.05). The number of acute attacks and the number of hospitalizations in the observation group were fewer than those in the control group, and the length of hospital stay was shorter than that of the control group, the differences were statistically significant (P<0.05). Conclusion Assisted transnasal high-flow oxygen therapy can improve lung function indexes of patients with acute bronchial asthma complicated by respiratory failure, shorten hospital stay and improve treatment effect, which is worthy of clinical promotion and application.
2021 Vol. 28 (3): 55-61 [Abstract] ( 47 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
58 Diagnostic value of pulmonary arterial systolic blood pressure for prognosis in patients with different types of shock
CAI Xue-min ；ZHENG Wei-hao ；ZHANG Shuang ；LI Chao-liang
Objective To observe pulmonary artery systolic pressure (PASP) of patients with different types of shock and evaluate the predictive value of PASP for death in shock patients. Methods The clinical data of 155 patients with shock who were admitted to Jiangmen Central Hospital from January 2017 to December 2018 were retrospectively analyzed. According to the type of shock, they were divided into septic shock group (93 cases), cardiogenic shock group(21 cases) and hypovolemic shock group (41 cases). The levels of blood lactate (LAC), N-terminal pro-B-type natriuretic peptide (NT-proBNP), white blood cell count (WBC) as well as the values of PASP in the patients were detected.Results PASP, NT-proBNP and mortality of the septic shock group were higher than those in hypovolemic shock group,the differences were statistically significant (P<0.05). NT-proBNP was lower than that in cardiogenic shock group, the difference was statistically significant (P<0.05). NT-proBNP and mortality in cardiogenic shock group were higher than those in hypovolemic shock group, the differences were statistically significant (P<0.05). PASP was positively correlated with NT-proBNP (r=0.289, P<0.05), while PASP was not correlated with LAC (P>0.05). Receiver operating characteristic (ROC) curve analysis results showed that PASP had better predictive value than NT-proBNP and LAC (P<0.05).Conclusion PASP is an effective death prediction index for patients with shock, which can better identify the occurrence and development of shock and improve the success rate of rescue of patients in critical medicine department. It is worthy of promotion and application in clinical practice.
2021 Vol. 28 (3): 58-61 [Abstract] ( 41 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
62 Clinical effect of ultrasound-guided stellate ganglion catheterization and continuous block for the treatment of head and neck postherpetic neuralgi
YU Yu ；LUO Jin-kun
Objective To investigate the clinical effect of ultrasound-guided continuous stellate ganglion catheter block in the treatment of post-herpetic neuralgia （PHN）. Methods A total of 80 patients with head and neck PHN admitted to Jiujiang Hospital of Traditional Chinese Medicine, Jiangxi Province from January 2018 to December 2019 were selected and were divided into observation group and control group according to the random number table method, 40 cases in each group. The control group was treated with conventional drugs, and the observation group was treated with conventional drugs combined with continuous stellate ganglion catheterization. The visual analogue scale (VAS) and emotional score (ES) of the two groups of patients before and at 1, 7, 14, and 28 days after treatment were compared.The improvement of patients was evaluated. Results The VAS and ES scores of the observation group were lower than those of the control group at 7, 14 and 28 days after treatment, the differences were statistically significant (P<0.05).The excellent and good rate of the observation group was 92.5%, which was higher than that of the control group of 77.5%, the difference was statistically significant (P<0.05). Conclusion The combined effect of drugs combined with ultrasound-guided continuous stellate ganglion catheter for the treatment of PHN is better than Western medicine alone, and it is worthy of clinical promotion.
2021 Vol. 28 (3): 62-64 [Abstract] ( 47 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
65 Effect of percutaneous compression hollow screw internal fixation combined with ankle passive motion instrument in the treatment of noncrushing ankle fracture
SHANG Lin
Objective To investigate the effect of percutaneous compression hollow screw fixation combined with ankle passive motion instrument in the treatment of non-crushing ankle fractures. Methods From June 2018 to January 2020,87 patients with non-crushing ankle fractures treated in Liaoyang Central Hospital, Liaoning Province were selected and divided into control group (43 cases) and observation group (44 cases) according to random number table method.Both groups were treated with percutaneous compression hollow screw internal fixation, and the postoperative control group received routine rehabilitation training, and the observation group was added with ankle passive therapy instrument. The healing time, ankle function, motor function and life ability of the two groups were compared. Results The fracture healing time in observation group was (71.28±15.67) d， shorter than that in the control group of (90.41±20.14) d,the difference was statistically significant (P<0.05). Total excellent and good rate of knee joint function in observation group was 95.45% (42/44), higher than that in the control group of 79.07% (34/43), the difference was statistically significant (P<0.05). Before treatment, comparison of motor function evaluation (FMA) and Barthel index (BI) between the two groups, the differences were not statistically significant (P＞0.05). After treatment, FMA score and BI index of two groups were higher than those before treatment, FMA score and BI index of the observation group were higher than those of the control group, the differences were statistically significant (P<0.05). Conclusion The ankle fracture percutaneous compression hollow screw internal fixation combined with ankle passive motion instrument can effectively promote fracture healing and ankle function recovery and improve motor function and life ability.
2021 Vol. 28 (3): 65-67 [Abstract] ( 49 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
68 Effect of fiberoptic bronchoscope alveolar lavage combined with Meropenem in the treatment of severe pulmonary infection
LIU Wen-yan
 Objective To investigate the effect of fiberoptic bronchoscopic alveolar lavage combined with Meropenem in the treatment of severe pulmonary infection. Methods A total of 80 patients with severe pulmonary infection admitted to People′s Hospital of Kaizhou District in Chongqing City from February 2017 to May 2019 were selected as the research objects. They were divided into the control group (40 cases) and the experimental group (40 cases) according to the random number method. The control group was treated with Meropenem, the experimental group took fibrobronchoscope alveolar lavage combined with Meropenem treatment, and the clinical efficacy, lung function indexes,clinical symptom recovery time and inflammatory indexes of patients of the two groups were compared. Results The total effective rate of the experimental group was higher than that of the control group, the difference was statistically significant (P<0.05). The maximal ventilatory volume (MMV), maximal middle expiratory flow (MMEF), and 1st second forced breathing volume/forced vital capacity (FEV1/FVC) in the experimental group were higher than those of the control group, the differences were statistically significant (P<0.05). The recovery time of body temperature and cough recovery time in experimental group were shorter than those in control group, the differences were statistically significant (P<0.05). There were no significant differences in white blood cell count (WBC) and procalcitonin (PCT)between the two groups before treatment (P>0.05). The WBC and PCT of the two groups after treament were lower than those before teatment, the differences were statistically significan (P<0.05). WBC and PCT levels in the experimental group after treatment were lower than those in the control group, the differences were statistically significant (P<0.05).Conclusion Fiberoptic bronchoscopic alveolar lavage combined with Meropenem has a definite curative effect on severe pulmonary infection, effectively improves the patient′s lung function and inflammatory index, and shortens the treatment time, so it is worth popularizing and applying.
2021 Vol. 28 (3): 68-70 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
71 Expression and clinical significance of serum ferritin, procalcitonin, C-reactive protein and interleukin-6 in patients with rheumatic disease coinfection
LIANG Cai-ping ；ZHONG Yan-ling ；JIANG Yan-zhang ；GAN Guo-neng ；LIU Qiao-min
Objective To investigate the significance of serum ferritin (SF), procalcitonin (PCT), C-reactive protein(CRP) and interleukin-6 (IL-6) in the diagnosis of rheumatic disease coinfection. Methods A total of 60 patients with rheumatic disease coinfection who were admitted to Yunfu People′s Hospital from January 2017 to December 2019 were retrospectively enrolled as the infected group, another 60 patients with rheumatic disease who were treated in the same period were selected as the non-infection group. The SF, PCT, CRP and IL-6 levels in two groups were comparatively analyzed. Results The levels of CRP, IL-6, SF and PCT in the infected group were higher than those in the noninfected group, the differences were statistically significant (P<0.05). The positive rates of SF, PCT, CRP and IL-6 in the infected group were higher than those in the non-infected group, the differences were statistically significant (P<0.05). Conclusion The levels of SF, PCT, CRP and IL-6 are significantly increased in patients with rheumatic diseases coinfection, and they can be used to assist in the diagnosis of secondary infections combined with the clinical symptoms. It is of great significance for the differential diagnosis of rheumatic diseases combined with infection.
2021 Vol. 28 (3): 71-73 [Abstract] ( 46 ) HTML (31 KB)  PDF  (0 KB)  ( 5 )
74 Effect of Lobaplatin combined with Paclitaxel induction chemotherapy on larynx preservation rate and the incidence of adverse reactions in patients with hypopharyngeal cancer
WANG Mei-yi
Objective To investigate the effect of Lobaplatin combined with Paclitaxel induction chemotherapy on the larynx preservation rate and the incidence of adverse reactions in patients with hypopharyngeal cancer. Methods A total of 72 patients with hypopharyngeal cancer admitted to Affiliated Zhongshan Hospital of Dalian University from November 2017 to January 2020 were selected as the research subjects. According to different treatment method, they were divided into the control group (37 cases) and the observation group (35 cases). In the control group, surgery+radiotherapy was used, and in the observation group, surgery+radiotherapy+Lobaplatin combined with Paclitaxel induction chemotherapy were adopted. The total effective rate, laryngeal preservation rate and the incidence of adverse reactions between the two groups were compared. Results The total effective rate of observation group was higher than that of control group, the larynx preservation rate in that observation group was high than that in the control group, the differences were statistically significant (P<0.05). Comparison of adverse reactions such as mucositis, neutropenia, nausea and vomiting and rash between the two groups, and the differences were not statistically significant (P>0.05). Conclusion Lobaplatin combined with Paclitaxel induction chemotherapy is effective in the treatment of hypopharyngeal cancer, which can increase the rate of laryngeal preservation in certain safety.
2021 Vol. 28 (3): 74-76 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
77 Effect of Levofloxacin and Pyrazinamide in treating elderly patients with pulmonary tuberculosis and hypertension and influence on renal function and adverse reactions
HUANGFU Bei-bei； CHEN Xiu-ying； LU Fu-rong
Objective To investigate the effect of Levofloxacin and Pyrazinamide in treating elderly patients with pulmonary tuberculosis and hypertension and influence on renal function and adverse reactions. Methods A total of 150 elderly patients with pulmonary tuberculosis and hypertension were selected from October 2017 to October 2019 in designated hospital in our city. They were divided into control group (75 cases) and study group (75 cases) according to random number table method. The control group was treated with Levofloxacin, Rifampicin, Ethambutol and Isoniazid.The study group was treated with Pyrazinamide, Rifampicin, Ethambutol and Isoniazid. The curative effect, the level of renal function and the influence of adverse reaction were compared between the two groups. Results After half a year of medication, the renal function indexes such as creatinine, serum cystatin, urea nitrogen, uric acid and urinary microalbumin of the study group were higher than those of the control group, the differences were statistically significant (P<0.05). The total incidence of adverse reactions in the study group was higher than that in the control group, the difference was statistically significant (P<0.05). The negative conversion rates of sputum bacteria of 1, 2 and 3 months after medication in the study group were higher than those in the control group, the differences were statistically significant (P<0.05). Conclusion In the treatment of senile pulmonary tuberculosis with hypertension,Pyrazinamide is more effective than Levofloxacin, and has a greater impact on renal function and adverse reactions,which should be paid attention in the course of treatment, strengthening the detection of all kinds of blood uric acid,and timely symptomatic treatment, as far as possible to reduce kidney injury.
2021 Vol. 28 (3): 77-79转86 [Abstract] ( 35 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
80 Effect of Tigecycline combined with Cefoperazone Sulbactam in the treatment of severe pneumonia caused by multi-drug resistant bacteria
ZUO Tong-kun ；TANG Qing ；HUI Liang-liang； ZHANG Xiang-cheng ；SHANG Fu-tai
Objective To explore the effect of Tigecycline combined with Cefoperazone Sulbactam in the treatment of severe pneumonia caused by multi-drug resistant bacteria. Methods A total of patients with severe pneumonia caused by multi-drug resistant bacteria treated in the Affiliated Huai′an NO.1 People′s Hospital of Nanjing Medical University from January 2017 to February 2020 were selected as research objects. According to the random number table method,they were divided into experimental group and control group, with 40 cases in each group. The experimental group took Tigecycline combined with Cefoperazone Sulbactam treatment, the control group was treated with Cefoperazone Sulbactam. The treatment efficiency, oxygen metabolism indexes, and adverse reactions of the two groups were compared. Results The total effective rate of experimental group after treatment was higher than that of control group, and the difference was statistically significant (P<0.05). After treatment, the indexes of oxygen saturation (SaO2), oxygen supply (DO2),and partial pressure of oxygen (PaO2) in the two groups were higher than those before treatment, and oxygen consumption(VO2) was lower than that before treatment, the differences were statistically significant (P<0.05). The indexes of SaO2,DO2, PaO2 in the experimental group were higher than those in the control group, and VO2 was lower than in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Patients with severe pneumonia caused by multi-drug resistant bacteria are treated with Tigecycline combined with Cefoperazone Sulbactam, which has a positive effect on improving the state of oxygen metabolism. The treatment effect is significant, and the safety of medication is high.
2021 Vol. 28 (3): 80-82转94 [Abstract] ( 39 ) HTML (37 KB)  PDF  (0 KB)  ( 8 )
83 Clinical effect of Pitavastatin Calcium Tablets combined with Aspirin in the treatment of coronary heart disease with hyperlipidemia
TONG Zao-ying
Objective To investigate the clinical effect of Pitavastatin Calcium Tablets combined with Aspirin in the treatment of coronary heart disease with hyperlipidemia. Methods Altogether 93 patients who had coronary heart disease with hyperlipidemia treated in Dexing People′s Hospital from March 2018 to February 2020 were selected as subjects and divided into control group (n=46) and observation group (n=47) according to the blind drawing method. The two groups were given conventional treatment, the control group was treated with Pitavastatin Calcium Tablets, while the observation group was treated with Aspirin on the basis of the control group. The clinical efficacy, blood lipid indexes and total incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group, and the total effective rate of the observation group(97.87%) was higher than that of the control group (82.61%), with statistically significant differences (P<0.05). After treatment, the levels of total cholesterol (TC) ([1.56±0.37] mmol/L), triacylglycerol (TG) ([3.13±0.54] mmol/L), low density lipoprotein cholesterol (LDL-C) ([2.19±0.36] mmol/L) in the observation group were lower than those before treatment ([4.38±1.01], [6.49±1.52], [5.24±1.01] mmol/L), the differences were statistically significant (P<0.05). The levels of TC ([2.31±0.47] mmol/L), TG ([4.61±0.98] mmol/L), LDL-C ([3.28±0.49] mmol/L) in the control group after treatment were lower than those before treatment ([4.36±1.03], [6.51±1.48], [5.33±1.05] mmol/L), the differences were statistically significant (P<0.05). The high density lipoprotein cholesterol (HDL-C) of the observation group after treatment was(2.03±0.34) mmol/L, which was higher than that before treatment ([0.86±0.13] mmol/L), the HDL-C of the control group after treatment was (1.56±0.28) mmol/L, which was higher than that before treatment ([0.85±0.12] mmol/L), the differences were statistically significant (P<0.05). And the levels of TC, TG and LDL-C of the observation group after treatment were lower than those of the control group, the HDL-C level of the observation group was higher than that of the control group, the differences were statistically significant (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the observation group (6.38%) and control group (13.04%) (P>0.05). Conclusion Pitavastatin Calcium Tablets combined with Aspirin has a significant effect in the treatment of coronary heart disease patients with hyperlipidemia, which can effectively improve patients′ blood lipid index, promote their physical recovery, and have high safety.
2021 Vol. 28 (3): 83-86 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
87 Study on the relationship between serum Hcy, Cys C and hs-CRP levels and IMT thickness in patients with hypertension
WEI Guan-chu ；HUANG Ying-jun
Objective To investigate the relationship between serum cystatin C (Cys C), homocysteine (Hcy), high sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (IMT) in patients with hypertension. Methods A total of 124 patients with hypertension admitted to Yangchun Hospital of Traditional Chinese Medicine from January 2019 to April 2020 were selected as the research objects, and they were divided into IMT normal group (37 cases), IMT thickening group (42 cases) and carotid plaque formation group (45 cases) according to IMT. Serum Hcy, Cys C and hs-CRP levels of three groups were compared, the correlation between IMT and serum Hcy, Cys C and hs-CRP levels was analyzed. Results The Hcy, Cys C and hs-CRP levels of carotid plaque formation group were (26.49±2.14) μmol/L,(2.55±0.19) mg/L and (6.04±1.23) mg/L, which were higher than those of IMT thickening group ([18.51±1.48] μmol/L,[1.97±0.14] mg/L, [2.86±0.75] mg/L) and IMT normal group ([11.68±1.23] μmol/L, [0.98±0.09] mg/L, [0.82±0.12] mg/L)respectively, the differences were statistically significant (P<0.05). IMT was positively correlated with serum Hcy, Cys C and hs-CRP levels (r=0.784, 0.793, 0.811, P＜0.05); multivariate Logistic regression analysis showed that Hcy, Cys C and hs-CRP were independent risk factors of carotid intimal thickening (P＜0.05). Conclusion Serum Hcy, Cys C and hs-CRP levels are positively correlated with IMT in patients with hypertension, and all of them are independent risk factors for carotid intimal thickening. Monitoring the serum Hcy, Cys C and hs-CRP levels can evaluate the condition and prognosis of patients with hypertension.
2021 Vol. 28 (3): 87-89 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
90 Effect and safety comparison of anticoagulant therapy of different doses of Rivaroxaban and Warfarin in elderly patients with non-valvular atrial fibrillation
WU Xuan； XU Xue-qing； WANG Jia-shu； WANG Kun
Objective To explore the effect and safety of anticoagulant therapy of different doses of Rivaroxaban and Warfarin in the treatment of elderly patients with non-valvular atrial fibrillation. Methods A total of 120 elderly patients with non-valvular atrial fibrillation treated in Wuhan No.7 Hospital from April 2015 to April 2019 were selected as the research objects. They were divided into the low-dose Rivaroxaban group (30 cases), the regular-dose Rivaroxaban group (30 cases), the high-dose Rivaroxaban group (30 cases), and the Warfarin group (30 cases) by random number table method. Patients in the low-dose Rivaroxaban group were treated with 5 mg Rivaroxaban, those in the regulardose Rivaroxaban group were treated with 10 mg Rivaroxaban, those in the high-dose Rivaroxaban group were treated with 20 mg Rivaroxaban, and those in the Warfarin group were treated with Warfarin. The coagulation function, thromboembolic events, bleeding events and adverse reactions of the four groups were compared. Results Comparison of coagulation function indexes before treatment among the four groups showed no statistically significant differences (P>0.05). Comparison of coagulation function indexes after treatment among the four groups showed no statistically significant differences (P>0.05). The prothrombin time (PT) of the four groups after treatment was longer than that before treatment, and the antithrombin Ⅲwas higher than that before treatment, with statistically significant differences (P<0.05). D-dimer levels after treatment in the four groups were lower than those before treatment, and the differences were statistically significant (P<0.05). Comparison of the total incidence of thromboembolic events among the four groups showed no statistically significant differences (P>0.05). Comparison of the total incidence of bleeding events among the four groups showed no statistically significant differences (P>0.05). The total incidence rates of adverse reactions in the four groups were compared, and the differences were not statistically significant (P>0.05). Conclusion Rivaroxaban at different doses and Warfarin are equally effective and safe in anticoagulation therapy for elderly patients with non-valvular atrial fibrillation. In view of the limitations of Warfarin therapy, low-dose Rivaroxaban should be the first choice for anticoagulation therapy in elderly patients with non-valvular atrial fibrillation.
2021 Vol. 28 (3): 90-94 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 8 )
95 Clinical effect of percutaneous coronary intervention in the treatment of angina pectoris in elderly patients with coronary heart disease
SHI Sheng-feng
Objective To explore the clinical effect of percutaneous coronary intervention (PCI) in the elderly patients with coronary heart disease and angina pectoris. Methods A total of 80 elderly patients with coronary heart disease and angina pectoris admitted to Haimen People′s Hospital from January 2016 to December 2018 were selected as the research objects, they were divided into the conservative treatment group (40 cases) and the PCI group (40 cases) according to the random number table method and voluntary principles. The conservative treatment group received conventional drug therapy, and the PCI group received PCI treatment, followed up for 12 months. The total effectiveness of treatment, Seattle angina questionnaire (SAQ) score, cardiac adverse events (recurrent angina pectoris, myocardial infarction, cardiogenic death) were compared between the two groups. Results The total effective rate of PCI group was 97.50%, higher than that of conservative group (85.00%), the difference was statistically significant (P<0.05). The SAQ scores of PCI group (angina attack, angina stable state, limited physical activity, subjective feeling and treatment plan satisfaction) were all higher than those of the conservative group, the differences were statistically significant (P<0.05).There was no significant difference in the incidence of cardiac adverse events between the two groups (P＞0.05). Conclusion PCI has a significant clinical effect on angina pectoris in elderly patients with coronary heart disease, which can improve the quality of life of elderly patients with coronary heart disease and angina pectoris, and is worthy of clinical application.
2021 Vol. 28 (3): 95-97 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
98 Analysis of influencing factors of residual stenosis after carotid artery stent implantation
LI Run-xiong
Objective To analyze the influencing factors of residual stenosis after carotid artery stent implantation.Methods Data of 152 patients with carotid artery stenosis (173 stents in total) who received carotid artery stent implantation in Dongguan People′s Hospital from February 2016 to February 2019 were retrospectively analyzed. Carotid angiography and color Doppler flow imaging (CDFI) were performed within 2 weeks before surgery, and CDFI was performed within 7 days after surgery. Patients were divided into residual stenosis group (n=36) and non-residual stenosis group (n=116) according to whether residual stenosis occurred after carotid artery stent implantation. The incidence of residual stenosis after carotid stenting was calculated. The clinical data and therapeutic effect of patients in residual stenosis group and non-residual stenosis group were compared. The influence of different structure characteristics of carotid artery stenosis on the incidence of residual stenosis after carotid stent implantation were analyzed. Multivariate Logistic analysis was used to investigate the risk factors for residual stenosis after carotid artery stenting. Results In 152 patients, the incidence of residual stenosis after carotid stenting was 23.68% (36/152), and 50 stents were inserted. The prevalence of hypertension in the residual stenosis group was 75.00%, higher than that in the non-residual stenosis group (64.66%), with a statistically significant difference (P<0.05). The total effective rate of the residual stenosis group was 97.22%, higher than that of the nonresidual stenosis group (81.90%), and the difference was statistically significant (P<0.05). There were no statistically significant differences in the incidence rates of residual stenosis after carotid artery stent implantation among patients with different stent locations, echo levels, and plaque calcification (P>0.05). Patients with preoperative vascular diameter <1.0 mm, heterogeneous echogenic plaque, surface calcification plaque, irregular plaque, and high grade of preoperative carotid artery contrast-enhanced ultrasound had higher incidence of residual stenosis after carotid stent implantation, and the differences were statistically significant (P<0.05). Multivariate Logistic regression analysis showed that hypertension (β=0.38, OR=1.48, 95%CI=0.90-2.38), preoperative vascular diameter < 1.0 mm (β=0.46, OR=1.60, 95%CI=1.05-2.43), surface calcified plaque (β=0.92, OR=2.54, 95%CI=1.46-4.48), irregular plaque (β=2.17, OR=9.01, 95%CI=5.20-15.58), and high grade of preoperative carotid artery contrast-enhanced ultrasound (β=0.65, OR=1.24, 95%CI=1.15-2.77) were risk factors for residual stenosis after carotid stent implantation (P<0.05). Conclusion Carotid stenosis in patients with vascular structure characteristics (such as preoperative blood vessel diameter, surface calcified plaque, irregular plaques, preoperative carotid ultrasound imaging classification, etc.) are the carotid stent implantation factors that influence the incidence of residual stenosis after carotid artery stent implantation. Therefore, it is recommended to select an appropriate way to treat patients with carotid artery stenosis in combination with imaging features.
2021 Vol. 28 (3): 98-101转105 [Abstract] ( 33 ) HTML (39 KB)  PDF  (0 KB)  ( 8 )
102 Effect comparison of Oxcarbazepine and Carbamazepine in the treatment of adult partial epilepsy
SHENG Lin-lin
 Objective To analyze the effect of Oxcarbazepine and Carbamazepine in the treatment of adult partial epilepsy and its effect on patients′ electroencephalogram. Methods A total of 180 adult patients with partial epilepsy who admitted to the Second Department of Neurology in Liaoning Health Industry Group Iron Coal General Hospital from August 2018 to August 2019 were selected as the research objects and divide into group A and B by random number table method, with 90 cases in each group. The group A was treated with Oxcarbazepine, and the group B was treated with Carbamazepine. Both groups were treated for 6 months. The therapeutic effect, cognitive function, electroencephalogram and side effects were compared between the two groups before and after treatment. Results The total effective rate in group A was 71.11%, which was higher than 54.44% in group B, and the difference was statistically significant(P<0.05). There were no statistically significant differences in full scale IQ (FIQ) scores between the two groups before treatment (P>0.05). After treatment, the FIQ score of group A was higher than that of group B, and the difference was statistically significant (P<0.05). After treatment, the θ power value of group A was higher than that before treatment, and the difference was statistically significance (P<0.05). There were no statistically significant differences in α,β and δ power values of group A before and after treatment (P>0.05). After treatment, the α power value of group B was lower than that before treatment, the θ power value was higher than that before treatment, and the differences were statistically significant (P<0.05). There were no statistically significant differences in β and δ power values of group B before and after treatment (P>0.05). The incidence of side effects in group A was 21.11% (19/90), which was lower than 48.89% (44/90) in group B, and the difference was statistically significantly (P<0.05). Conclusion Compared with Carbamazepine, Oxcarbazepine can effectively improve the cognitive function of patients with partial epilepsy in adults,can significantly inhibit epilepsy-like discharge, and has little effect on electroencephalogram background activity and few side effects. It is suitable for clinical application.
2021 Vol. 28 (3): 102-105 [Abstract] ( 44 ) HTML (35 KB)  PDF  (0 KB)  ( 5 )
106 Clinical effect comparison of minimally invasive neuroendoscopic surgery and microsurgery in the treatment of hypertensive cerebellar hemorrhage
LI Wen-sheng； HUANG Rui-hong
Objective To compare the clinical effect of minimally invasive neuroendoscopic surgery and microsurgery in the treatment of hypertensive cerebellar hemorrhage. Methods A total of 82 patients with hypertensive cerebellar hemorrhage who were admitted to the Second Hospital of Sanming City in Fujian Province from January 2015 to December 2019 were divided into the observation group and the control group according to random number table method,with 41 cases in each group. The observation group was treated with minimally invasive neuroendoscopic surgery, and the control group was treated with traditional craniotomy under microscope. The incision length, operation time, intraoperative bleeding, bone window area, hospital stay, hematoma clearance rate, postoperative complications and outcome were compared between the two groups. Results The intraoperative bleeding in the observation group was less than that of the control group, the bone window area was smaller than that of the control group, the length of incision, the operation time and hospitalization time were shorter than those of the control group, the clearance rate of hematoma was higher than that of the control group, and the differences were statistically significant (P<0.05). The total complication rate in the observation group was lower than that in the control group, and the difference was statistically significant(P<0.05). The good rate of prognosis in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Minimally invasive neuroendoscopic surgery for hypertensive cerebellar hemorrhage has the advantages of short operation time, high clearance rate of hematoma, less trauma and less bleeding, which is helpful to promote the recovery of nerve function, reduce postoperative complications and improve prognosis.
2021 Vol. 28 (3): 106-108 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 5 )
109 Analysis of influence factors of postoperative recurrence in patients with urinary calculi after lithotomy
CHEN Zhi-wei； LI Wei；HUANG Zhi-jin； HUANG Yue-jian； LI Fa-jiang； WANG Yan
Objective To analyze the influence factors of postoperative recurrence in patients with urinary calculi after lithotomy, and to provide the reference for choosing reasonable preventive measures. Methods Clinical data of 150 patients with recurrent urinary calculi who were treated in Banfu Hospital of Zhongshan City, Guangdong Province from January to December 2019 were retrospectively analyzed. The recurrence related factors and independent risk factors were analyzed. Results A total of 22 cases recurred in 150 patients, the recurrence rate was 14.67%. The results of single factor analysis showed that different body mass index, with or without family history of stones, urinary tract infection,metabolic abnormality, different dietary habits, number of stones were significantly correlated with stone recurrence rate, and the differences were statistically significant (P<0.05). Multivariate Logistic analysis showed that body mass index≥25 kg/m2, urinary tract infection, metabolic abnormality and sweet and greasy eating habits were independent risk factors for stone recurrence (P<0.05). Conclusion The patients with urinary calculi need to pay attention to weight control, develop good eating habits, with less sweet and greasy, and receive standardized rehabilitation treatment to avoid metabolic disorders, urinary tract infection and other adverse conditions, so as to reduce the recurrence rate.
2021 Vol. 28 (3): 109-111转118 [Abstract] ( 44 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
112 Effect of percutaneous nephrolithotripsy in the treatment of complex renal calculi
LI Hua-qiang ；CHEN Shao-na ；KANG Yong-sheng ；TANG Yun-feng； SONG Dong-xia
Objective To explore the effect of percutaneous nephrolithotripsy (PCNL) in the treatment of complex renal calculi. Methods The clinical data of 64 patients with complex renal calculi who were admitted to Lianjiang People′s Hospital in Guangdong Province from October 2017 to October 2019 were retrospectively analyzed and divided into the control group and the observation group according to different treatment methods, with 32 cases in each group. The control group was treated with open surgery and the observation group was treated with PCNL. The clinical indicators(operative time, intraoperative blood loss, renal fistula catheter retention time), stone clearance rate, stone recurrence rate and serum creatinine (SCr) levels in the two groups were compared. Results The operative time and renal fistula catheter retention time of the observation group were shorter than those of the control group, the intraoperative blood loss was less than that of the control group, and the differences were statistically significant (P<0.05). The stone clearance rate of the observation group was higher than that of the control group, the stone recurrence rate was lower than that of the control group, and the differences were statistically significant (P<0.05). After treatment, the SCr levels in both groups were lower than those before treatment, the SCr level in the observation group was lower than that in the control group, and the differences were statistically significant (P<0.05). Conclusion The application of PCNL in the treatment of patients with complex renal calculi can not only shorten the operation time and reduce intraoperative blood loss, but also improve the stone clearance rate, effectively improve renal function and reduce the recurrence of stones.
2021 Vol. 28 (3): 112-114 [Abstract] ( 39 ) HTML (31 KB)  PDF  (0 KB)  ( 4 )
115 Effect of high-flux dialysis combined with hemoperfusion on inflammatory factors and quality of life in elderly chronic renal failure maintenance hemodialysis patients
GUAN Xing-ye
Objective To explore the effect of high-flux dialysis combined with hemoperfusion on inflammatory factors and quality of life in elderly chronic renal failure maintenance hemodialysis patients. Methods A total of 152 patients with chronic renal failure who were admitted to Liaoyang Infectious Diseases Hospital of Liaoning Province from May 2017 to November 2019 were selected as the research objects and divided into the control group and the observation group according to the random number table method, with 76 cases in each group. The control group was treated with high-flux dialysis, and the observation group was treated with high-flux dialysis combined with hemoperfusion. Both groups were treated continuously for 2 months. The levels of blood calcium, blood phosphorus, intact parathyroid hormone (iPTH), inflammatory factors and quality of life were compared between the two groups. Results There were no statistically significant differences in levels of blood calcium, blood phosphorus and iPTH of the two groups before treatment (P>0.05). After 2 months of treatment, the blood calcium and iPTH levels of the two groups were lower than those before treatment, the blood phosphorus levels were higher than those before treatment, and differences were statistically significant (P<0.05). After 2 months of treatment, the blood calcium and iPTH levels of the observation group was lower than that of the control group, the blood phosphorus levels were higher than those of the control group, and differences were statistically significant (P<0.05). There were no statistically significant differences in interleukin-6(IL-6) and tumor necrosis factor-α (TNF-α) between the two groups before treatment (P>0.05). After 2 months of treatment, the levels of IL-6 and TNF-α in the two groups were lower than those before treatment, and differences were statistically significant (P<0.05). After 2 months of treatment, the levels of IL-6 and TNF-α in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in general quality of life inventory (GQOLI-74) score between the two groups before treatment (P>0.05). After 2 months of treatment, the GQOLI-74 scores of the two groups were higher than those before treatment, and the differences were statistically significant (P<0.05). After 2 months of treatment, the GQOLI-74 score of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion High-flux dialysis combined with hemoperfusion for senile chronic renal failure patients with maintenance hemodialysis can improve calcium-phosphorus metabolism disorder and iPTH secretion disorder, decrease inflammatory state and increase quality of life, which has better clinical efficacy.
2021 Vol. 28 (3): 115-118 [Abstract] ( 42 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
119 Application of mini nutrition assessment short form in the elderly patients with chronic kidney disease
LI Bi-hui
Objective To explore the clinical application value of mini nutrition assessment short form (MNA-SF) in evaluating the nutritional status of elderly patients with chronic kidney disease (CKD). Methods A total of 300 elderly patients with CKD who were admitted to Zhuzhou Central Hospital of Hu′nan Province from January 1 to December 31,2018 were selected as the research objects and the nutritional status of the patients was evaluated by the new MNA-SF within 48 hours after admission. The patients were divided into the normal nutrition group (n=87), malnutrition risk group (n=170) and malnutrition group (n=43) according to the MNA-SF score. The reliability of MNA-SF was evaluated by Cronbach′s α coefficient, and the degree of correlation of each index of MNA-SF was evaluated by Kaiser Meyer Olkin (KMO) and Bartlett spherical test. Nutrition-related indicators such as serum albumin (ALB), prealbumin (PA),transferrin (TF), hemoglobin (Hb), glucose (Glu), and C-reactive protein (CRP) were compared among the three groups.The value of MNA-SF in assessing nutritional status was analyzed using the receiver operating characteristic (ROC)curve. The internal consistency analysis of MNA-SF showed that the Cronbach′s α coefficient of MNA-SF was 0.723>0.7, which indicated that MNA-SF had a stable reliability. The KMO and Bartlett spherical test showed that KMO=0.819>0.5, indicated that the factor analysis could be carried out. Bartlett spherical test χ2=26.439 (P<0.05), indicated that the spherical hypothesis was rejected, and each index was not independent, and had a certain correlation, which was suitable for factor analysis. The characteristic values of 7 factors in MNA-SF (diet change, activity ability, neuropsychiatric disease, body mass reduction, body mass index [BMI], calf circumference [CC], stress or acute disease)were >1, and the contribution rate of cumulative variance was 84.07%, showed that the structure of MNA-SF was reasonable. The incidence of malnutrition in elderly patients with CKD was 14.33% (43/300). The age of patients in the malnutrition risk group and the malnutrition group was higher than that in the normal nutrition group, and the proportion of males was higher than that in the normal nutrition group, and the differences were statistically significant(P<0.05). BMI, CC, ALB, PA, TF and Hb in the risk group and the malnutrition group were lower than those in the normal group, and the differences were statistically significant (P<0.05). There were no statistically significant differences in Glu and CRP among the three groups (P>0.05). Conclusion MNA-SF has stable reliability and validity. It can be used as a tool to evaluate the nutritional status of elderly CKD patients, and has positive clinical significance for improving the prognosis of early nutritional metabolism intervention.
2021 Vol. 28 (3): 119-122 [Abstract] ( 44 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
123 Clinical study of epididymal inflammatory mass in 1021 patients with varicocele
WANG Rui1；LYU Kun-long； ZHENG Tao；ZHANG Tian-biao； NAN Yong-hao； HAO Ya-wei； ZHANG Jie
 Objective To observe the occurrence of epididymal inflammatory mass in 1021 patients with varicocele and explore the relationship between varicocele and epididymal inflammatory mass. Methods A total of 1128 male infertility patients who were admitted to the Department of Andrology in the First Affiliated Hospital of Zhengzhou University from December 2011 to May 2015 were selected as the research objects. The patients with varicocele were diagnosed,the side and degree of varicocele were distinguished, the location and number of epididymal inflammatory masses were recorded according to the results of physical examination and scrotal ultrasound. The location and incidence of epididymal inflammatory mass in patients with varicocele and non-varicocele, the incidence of epididymal inflammatory mass in patients with different varicocele side and different varicocele degrees were compared. The effects of epididymal inflammatory mass on scrotal temperature, sex hormones and semen quality in patients with varicocele were analyzed.Results There were 1021 cases in the varicocele group and 107 cases in the non-varicocele group. The incidence of epididymal inflammatory mass in the patients with varicocele was higher than that without varicocele, and the difference was statistically significant (P<0.05). The incidence of epididymal inflammatory mass in unilateral varicocele patients was higher than that in bilateral varicocele patients, and the difference was statistically significant (P<0.05). The incidence of epididymal caudal inflammatory masses in the severe varicocele patients was higher than that in the mild to moderate varicocele patients, and the difference was statistically significant (P<0.05). There were no significant differences in sperm concentration, total sperm count and sex hormone levels between the varicocele with epididymal inflammatory mass and the varicocele without epididymal inflammatory mass (P>0.05). The scrotal temperature of the varicocele with epididymal inflammatory mass was higher than that of the varicocele without epididymal inflammatory mass, the proportions of sperm forward movement and seminal plasma neutral glucosidase varicocele in patients with epididymal inflammatory mass were lower than those of the patients without epididymal inflammatory mass, and the differences were statistically significant (P<0.05). Conclusion The incidence of epididymal inflammatory masses in patients with varicocele significantly increase. The incidence of epididymal caudal inflammatory masses in the severe varicocele patients significantly increase. Compared with the varicocele patients without epididymal inflammatory mass,the varicocele patients with epididymal inflammatory mass has lower neutral glucosidase level, increase scrotal temperature and decrease sperm motility.
2021 Vol. 28 (3): 123-126 [Abstract] ( 50 ) HTML (41 KB)  PDF  (0 KB)  ( 10 )
127 Correlation between serum vitamin D, calcium ion level and anemia in patients with diabetic chronic kidney disease
XU Qian
 Objective To explore the correlation between serum vitamin D, calcium ion level and anemia in patients with diabetic chronic kidney disease. Methods A total of 80 patients with diabetic chronic kidney disease who were admitted to Zhuanghe Hospital of Traditional Chinese Medicine in Liaoning Province from May 2018 to April 2020 were selected as the research objects and divided into the control group and anemia group according to weather or not anemia, with 40 cases in each group. The clinical data of the patients were collected, the levels of calcium ion,phosphorus ion and 25-hydroxyvitamin D3 were compared between the two groups, and univariate and multivariate Logistic regression were used to analyze the risk factors of anemia in diabetic chronic kidney disease. Results Serum 25-hydroxyvitamin D3 level in patients with stage 3 diabetic chronic kidney disease was higher than that in patients with stage 4 and stage 5, and the difference was statistically significant (P<0.05). The level of calcium ions in anemia group was lower than that in control group,and the difference was statistically significant(P<0.05).The level of phosphorus ions was higher than that in control group, and the difference was statistically significant (P<0.05). The level of 25-hydroxyvitamin D3 was lower than that in control group,and the difference was statistically significant (P<0.05).Univariate analysis showed that hypocalcemia, hyperphosphatemia and the ratio of 25-hydroxyvitamin D3 reductions in anemia group were higher than those in control group, and the differences were statistically significant (P<0.05). Multivariate analysis showed that hypocalcemia (β=1.509, OR=1.819, 95%CI=1.219-2.008), hyperphosphatemia (β=1.711, OR=1.586, 95%CI=1.035-2.957) and 25-hydroxyvitamin D3 reductions (β=1.978, OR=2.079, 95%CI=1.596-2.245) were independent risk factors for anemia in patients with diabetic chronic kidney disease (P<0.05). Conclusion The decreased levels of vitamin D and calcium are the risk factors for anemia in patients with diabetic chronic kidney disease.
2021 Vol. 28 (3): 127-129 [Abstract] ( 49 ) HTML (37 KB)  PDF  (0 KB)  ( 8 )
130 Antibiotics prevention for operative hysteroscopy: A randomized controlled clinical trial
YANG Bei ；WANG Wei ；ZHUANG Qiu-chan； WANG Xiang-zhen
 Objective To explore the effect of prophylactic use of antimicrobial agents during hysteroscopy to prevent postoperative infection and to evaluate the clinical necessity. Methods A total of 90 patients (diagnosed as endometrial polyp, submucous myoma or endometrial hyperplasia) admitted to Nanshan Maternity & Child Healthcare Hospital of Shenzhen from January to December 2019 were selected as the research objects and divided into the non-antibacterial group (49 cases) and the antimicrobial group (41 cases) according to the random allocation method. Non-antibacterial group did not use antimicrobial agents before hysteroscopy, and the antimicrobial group used antibiotics at 30 min before hysteroscopy. The primary postoperative indicators (post-operative fever, infection and pain) and secondary postoperative indicators (antimicrobial-induced allergic reactions, abdominal distension, dizziness, headache, diarrhea,vomiting, and adverse reactions such as nausea) were compared between the two groups. Results There were no significant differences in the incidence rates of fever and pain in major postoperative indicators between the two groups(P>0.05). There were no infection, uterine bleeding, pelvic inflammatory disease, pelvic abscess, cervicitis/vaginitis and endometritis occurring in both groups. Anaphylaxis occurred in 2 patients of the antimicrobial group. There were no significant differences in the incidence rates of abdominal distension, dizziness, headache, diarrhea, vomiting, nausea and other adverse reactions between the two groups (P>0.05). Conclusion Preventive use of antimicrobial agents can not reduce the incidence of infection after hysteroscopy. Under the condition of perioperative management and following the management system of nosocomial infection, antimicrobial agents can be considered for low-risk patients.
2021 Vol. 28 (3): 130-133 [Abstract] ( 41 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
134 Study of relationship between children′s lobar pneumonia and trace elements
XU Jie ；ZHANG Lei
Objective To explore the relationship between children′s lobar pneumonia and five common trace elements.Methods A total of 65 children who had lobar pneumonia and treated in Shanghai Pudong New Area People′s Hospital from July 2018 to June 2019 were selected as the experimental group. During the same period, 65 healthy children from 1 to 12 years old came to the hospital for healthy checkup as the control group. Trace elements of the two groups were detected. Results The levels of zinc, calcium, magnesium and iron in the experimental group were lower than those in the control group, the differences were statistically significant (P<0.05). The children with trace elements deficiency in the experimental group were more than those in the control group, the difference was statistically significant(P<0.05). There was no significant correlation between the content of trace elements and sex between the two groups(P＞0.05). Conclusion Children with deficiency of trace elements will have a bigger chance to get respiratory system infection and lead to lobar pneumonia, and need to pay attention to the check and supplement of trace element and have children fed with balanced nutrition in order to avoid lobar pneumonia.
2021 Vol. 28 (3): 134-136 [Abstract] ( 39 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
137 Influence of recommended energy in Chinese Dietary Reference Intakes(2013 Edition) on the weight, blood glucose and pregnancy outcome of pregnant women with gestational diabetes mellitus
ZHAN Fang ；WANG Ting ；YUAN Jian； YUE Xiao-ling
 Objective To explore the effect of recommended energy in Chinese Dietary Reference Intakes (2013 Edition) (2013 DRIS) on the weight, blood glucose and pregnancy outcome of pregnant women with gestational diabetes mellitus (GDM). Methods A total of 482 pregnant women who were diagnosed with GDM in the Obstetric Nutrition Clinic of Dalian Maternal and Child Health Hospital from January 2018 to May 2019 were selected and were given medical nutrition therapy (MNT) both. They were divided into experimental group (n=248) and control group (n=234)according to the order of visits. In the experimental group, the recommended energy of 2013 DRIS was used, and in the control group, the recommended energy of Guidelines for Diagnosis and Treatment of Diabetes in Pregnancy 2014 was used. Follow up until delivery. Weight gain, blood glucose level, blood glucose control during pregnancy, pregnancy outcome, neonatal condition, and total incidence of delivery complications were compared between the two groups. Results The weight increase of pregnant women in the experimental group was greater than that of the control group, and the total protein and albumin levels after intervention were higher than those of the control group, with statistically significant differences (P<0.05). Fasting blood glucose and blood glucose 2 h after meal in both groups after intervention were lower than those before intervention, and the differences were statistically significant (P<0.05). There were no statistically significant differences between the two groups in fasting blood glucose, blood glucose 2 h after meal and glycosylated hemoglobin after intervention (P>0.05). The incidence of premature birth in the experimental group was lower than that in the control group, and the difference was statistically significant (P<0.05). The incidence of low birth weight infants in the experimental group was lower than that in the control group, and the difference was statistically significant (P<0.05). There were no statistically significant differences between the two groups in blood glucose control pass rate, urine ketone positive rate, newborn birth weight, total incidence of delivery complications, cesarean section rate, and incidence of macrosomia (P>0.05). Conclusion The use of energy recommended by 2013 DRIS for pregnant women with GDM is more conducive to reasonable weight gain during pregnancy, improving the nutritional status of pregnant women, reducing the incidence of preterm and low birth weight infants, without affecting the effect of blood sugar control.
2021 Vol. 28 (3): 137-141 [Abstract] ( 31 ) HTML (46 KB)  PDF  (0 KB)  ( 8 )
142 Clinical effect of retroperitoneal laparoscopic surgery in the treatment of children with severe congenital hydronephrosis
ZHOU Peng
Objective To explore the clinical effect of retroperitoneal laparoscopic surgery in the treatment of severe congenital hydronephrosis in children. Methods A total of 80 children with severe congenital hydronephrosis admitted to Zibo Maternal and Child Health Hospital from April 2017 to December 2019 were selected as the research objects.They were divided into two groups by a random number table method, with 40 cases in each group. The control group underwent conventional laparotomy, and the observation group underwent retroperitoneal laparoscopic surgery. The changes in glomerular filtration rate before and after the operation were compared. The thickness and area of renal parenchyma were compared between the two groups after 3 months. Renal function and postoperative complications were compared between the two groups after treatment. Results After 24 hours and 7 days after operation, the glomerular filtration rate of the two groups was higher than that before operation, and that of the observation group was higher than that of the control group, the differences were statistically significant(P＜0.05); at the follow-up 3 months later, the renal parenchymal thickness and area of the observation group were greater than those of the control group, and the differences were statistically significant (P＜0.05); the levels of urea nitrogen and blood creatinine in the renal function indexes of the observation group were lower than those of the control group group, the differences were statistically significant (P＜0.05); the total incidence of postoperative complications in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Compared with conventional open surgery, retroperitoneal laparoscopic surgery in children with congenital severe hydronephrosis can more effectively protect the renal function of the patients, promote the regeneration of renal parenchymal tissue and the recovery of renal function after surgery, and has fewer complications and high safety.
2021 Vol. 28 (3): 142-144 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
145 Effect of hormone replacement therapy on hypothyroidism or subclinical hypothyroidism during pregnancy
WU Yan-hua ；ZHOU Jing ；ZENG Li-na
Objective To explore and analyze the application value of hormone replacement therapy in pregnancy with hypothyroidism or subclinical hypothyroidism. Methods A total of 117 pregnant women with hypothyroidism and subclinical hypothyroidism in Nanshan Shekou People′s Hospital of Shenzhen from January 2018 to November 2019 were selected and divided into control group (53 cases) and observation group (64 cases) according to the order of hospitalization. The control group was treated with conventional treatment, and the observation group was treated with hormone replacement therapy. Thyroid function, incidence of complications, postpartum hemorrhage and pregnancy outcome were compared between the two groups before and after treatment. Results After 6 weeks of treatment, the thyroid stimulating hormone, serum free thyroxine and serum free triiodothyronine in the observation group were lower than those in the control group, the differences were statistically significant (P<0.05). The total incidence of complications in the observation group was not statistically significant compared with that in the control group (P>0.05). The bleeding of 2 h postpartum and 24 h postpartum in the observation group was less than that in the control group, the differences were statistically significant (P<0.05). The gestational week of delivery in the observation group was longer than that in the control group, and the milk opening rate, neonatal weight, Apgar score and pH value of umbilical artery blood gas in the observation group were higher than those in the control group, the differences were statistically significant (P<0.05).Conclusion The drug treatment for pregnant women with hypothyroidism or subclinical hypothyroidism should be based on conventional treatment, and then combined with hormone replacement therapy; it has significant advantages in improving blood lipid level, improving thyroid function and improving pregnancy outcome.
 
2021 Vol. 28 (3): 145-147 [Abstract] ( 29 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
148 Effect of adenoidectomy treating children with sinusitis
YAO Hai-bo； PANG Tao；WANG Xiao-hui
Objective To explore the curative effect of adenoidectomy on sinusitis in children. Methods A total of 112 children with sinusitis admitted to Capital Healthcare Hospital for Children and Women from February 2017 to February 2019 were selected as observation objects and divided into observation group (56 cases) and control group (56 cases) according to random number table method. The children in the control group took conservative treatment measures. The children in the observation group were treated with adenoidectomy on the basis of conservative treatment.The children were followed up for 6 months, and the total effective rate of the two groups for 1 month (when drug was stopped) and 6 months after treatment was observed. Results After one month of treatment, the total clinical effective rate of the observation group was higher than that of the control group, with statistically significant difference (P<0.05).After 6 months of treatment, the total clinical effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P<0.05). Conclusion Adenoidectomy on the basis of conservative treatment can significantly improve the short-term and long-term therapeutic effects of sinusitis in children.
2021 Vol. 28 (3): 148-150 [Abstract] ( 41 ) HTML (29 KB)  PDF  (0 KB)  ( 8 )
151 Analysis of clinical characteristics of benign infantile convulsions associated with mild gastroenteritis
WANG Yang
Objective To summarize and investigate the clinical characteristics of benign infantile convulsions associated with mild gastroenteritis. Methods A total of 56 patients with BICE admitted to Children′s Hospital of Shenyang from October 2018 to October 2019 as the research objects, the clinical data of age of onset, clinical features of convulsions, results of laboratory examination, prognosis and follow-up were collected and retrospectively analyzed. Results A total of 56 cases of BICE, all cases were acute onset, 75.00% were children aged 1-2years, the first attack of convulsion in 62.50% of cases occurred on the 1st to the 3rd day of the disease, the duration of convulsion in 66.07% of cases was less than 3 minutes and the times of convulsion occurred in 76.78% of cases was 1 to 2 times. Comparison among groups of different age, time of first onset convulsion, duration of convulsion and number of convulsations in 1 episode,the differences were statistically significant (P<0.05). The ratio of positive rotavirus antigen in their faeces was 54.35%.Only 5 cases of electroencephalogram (EEG) were mildly abnormal, other cases of EEG were normal. Creatine phosphokinase-MB (CK-MB) of 67.86% cases in BICE increased. The ratio of level of blood calcium decreasing in 31 cases was 54.84%. They all had good prognosis. During the follow-up, no BICE recurred and abnormal EEG returned normal. Conclusion BICE is a common benign infantile convulsion. Convulsion occurs more common for 1 to 2 times, the duration of convulsion is short and prognosis is good. The pathogenesis of BICE may be associated with rotavirus infection. Myocardial damage in most of cases and hypocalcemia in some cases are found. Active targeted treatment is needed to prevent convulsion.
2021 Vol. 28 (3): 151-153 [Abstract] ( 68 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
154 Clinical effect of key-key way precision attachment denture in the treatment of posterior dental dissociation loss
JIANG Tao
Objective To investigate the clinical effect of key-key way precision attachment denture in the treatment of posterior dental dissociation loss. Methods A total of 96 patients with posterior dental dissociation loss admitted to the Third People′s Hospital of Dalian City from January 2017 to September 2018 were selected as study subjects, and were divided into control group (48 cases) and study group (48 cases) by random number table method. Patients in the control group were treated with conventional method, while patients in the study group were treated with key-key way precision attachment denture. Both groups were treated for 2 weeks consecutively. The periodontal exploration depth, gingival index, retention force, masticatory function, satisfaction rate of denture, and repair failure were compared between the two groups. Results There were no significant differences in the periodontal exploration depth, gingival index, retention force, masticatory function between the two groups on the first wear (P>0.05). After wearing for 1 year, there was no statistically significant difference in the periodontal exploration depth between the two groups (P>0.05). After wearing for 1 year, gingival index of the study group was lower than that of the control group, retention force and masticatory function were higher than those of the control group, with statistically significant differences (P<0.05). There was no statistically significant difference between the two groups in the periodontal exploration depth after wearing for 1 year and on the first wear (P>0.05). The gingival index and masticatory function of the two groups after wearing for 1 year were higher than those on the first wear, with statistically significant differences (P<0.05). The retention force of patients in the two groups after wearing for 1 year was lower than that on the first wear, and the difference was statistically significant (P<0.05). The total satisfaction rate of the study group was higher than that of the control group, and the difference was statistically significant (P<0.05). There were no patients with repair failure in study group and control group. Conclusion In the treatment of posterior dental dissociation loss, the therapeutic effect of key-key way precision attachment denture is obvious, which is worth applying.
2021 Vol. 28 (3): 154-157 [Abstract] ( 46 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
158 Clinical effect of special repair measures in oral repair of mandibular single jaw total denture
MA Liang
 Objective To explore the clinical effect of special repair measures in oral repair of mandibular single jaw total denture.Methods From February 2018 to February 2020,100 patients with oral repair of mandibular single jaw total denture admitted to Liaoning Health Industry Group Iron Coal General Hospital were selected as the research objects.They were divided into observation group(50 cases)and control group(50 cases)according to the random grouping method of single or double number. Patients in the control group were treated with traditional repair measures, while those in the observation group were treated with special repair measures. Dental function scores, success rate of repair, incidence of complications, satisfaction with chewing ability, satisfaction with stability, satisfaction with aesthetics and satisfaction with comfort were compared between the two groups. Results The scores of speech function, chewing function,swallowing function, chewing ability satisfaction, stability satisfaction, aesthetic satisfaction, comfort satisfaction and repair success rate of patients in the observation group after treatment were all higher than those in the control group,with statistically significant differences (P<0.05). The complication rate of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion The application of special repair measures in the oral repair of mandibular single jaw total denture can improve the appearance satisfaction and comfort satisfaction of patients, as well as the masticatory function of patients, which is worthy of clinical application.
2021 Vol. 28 (3): 158-160 [Abstract] ( 37 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
161 Clinical effect of anti-vascular endothelial growth factor drug combined with laser photocoagulation in the treatment of retinal vein occlusion with macular edema
MENG Xiao-ying

Objective To observe the clinical effect of anti-vascular endothelial growth factor (VEGF) drug combined with laser photocoagulation in the treatment of retinal vein occlusion with macular edema (RVO-ME). Methods Retrospective analysis was conducted on the clinical data of 84 patients with RVO-ME diagnosed and treated in Liaoyang Central Hospital from June 2018 to December 2019. Patients were divided into control group (n=32, 32 eyes) and observation group (n=52, 52 eyes) according to different treatment methods. Patients in the control group were given anti-VEGF drug therapy, while patients in the observation group were treated with laser photocoagulation on the basis of anti-VEGF drug therapy. Postoperative follow-up was conducted for 5 months, the best corrected visual acuity (BCVA)and macular central visual acuity fovea thickness (CMT) of the two groups before and after treatment were compared.Results After treatment, BCVA in the observation group (0.64±0.27) was higher than that in the control group (0.49±0.32), with statistically significant difference (P<0.05). After treatment, the CMT of the observation group ([258.39±102.44] μm) was smaller than that of the control group ([310.42±96.56] μm), and the difference was statistically significant (P<0.05). Conclusion The treatment of RVO-ME with anti-VEGF drug combined with laser photocoagulation can effectively improve the patients′ vision and reduce CMT. Compared with the treatment of anti-VEGF drug alone, the treatment of anti-VEGF drug combined with laser photocoagulation has a better effect, which is worthy of clinical promotion and application.
2021 Vol. 28 (3): 161-163 [Abstract] ( 44 ) HTML (33 KB)  PDF  (0 KB)  ( 5 )
164 Application of awake tracheal intubation under video laryngoscope in emergency operation of full stomach patients
LIU Chang-wei； LIU Fei-rong； XUE Song； HE Chun-cong； LIU Jun
Objective To explore the application of awake tracheal intubation under video laryngoscope in emergency operation of full stomach patients. Methods A total of 56 patients in Dongguan Guangji Hospital who needed emergency surgery under general anesthesia with awake endotracheal intubation (intubation) due to full stomach were selected as study subjects. According to the random number table method, the patients were divided into the video laryngoscope(VL) group (28 cases) and the fiberbronchoscope (FOB) group (28 cases). The VL group underwent plastic intubation with tracheal tube core under video laryngoscopy, and the FOB group underwent fiberoptic bronchoscope to guide the intubation. The intubation time, the first-pass success rate of tracheal intubation, the score of patient cooperation, the score of satisfaction with intubation during follow-up within 24 hours after anesthesia, and the incidence of adverse reactions during intubation were compared between the two groups. Results VL group′s intubation time was shorter than FOB group, the difference was statistically significant (P<0.05). There were no statistically significant differences in the first-pass success rate of intubation, patient cooperation score, follow-up satisfaction score, and total incidence of adverse reactions between the two groups (P>0.05). Conclusion For full-stomach patients undergoing awake endotracheal intubation during general anesthesia, compared with bronchoscope-guided intubation, video laryngoscope intubation could shorten the intubation time, and the success rate of one intubation, the degree of patient cooperation and intubation satisfaction are comparable, without increasing the incidence of adverse reactions to intubation.
2021 Vol. 28 (3): 164-167 [Abstract] ( 46 ) HTML (39 KB)  PDF  (0 KB)  ( 7 )
168 Application of ultrasound-guided thoracic wall nerve block in modified radical mastectomy for breast cancer
CHANG ；Yi TIAN Yu
Objective To explore the application value of ultrasound-guided thoracic wall nerve block in modified radical mastectomy for breast cancer. Methods A total of 80 patients underwent modified radical mastectomy for breast cancer under general anesthesia and endotracheal intubation in Dalian Central Hospital from June 2019 to April 2020 were selected as the research subjects. They were divided into an observation group (40 cases) and a control group(40 cases) according to the random number table method. The observation group received ultrasound-guided thoracic wall nerve block, and the control group received ultrasound-guided thoracic paravertebral nerve block. The relative indexes of anesthesia resuscitation, subjective and objective indexes of anesthesia resuscitation and analgesic effect within 48 hours after anesthesia were compared between the two groups. Results The recovery time of breathing,consciousness and tracheal catheter removal time were shorter in the observation group than those in the control group,the differences were statistically significant (P<0.05). When they woke up from anesthesia, the numerical rating score(NRS) of the observation group was lower than that of the control group, and the serum levels of substance P (SP) and serum neuropeptide (NPY) were lower than those of the control group, the differences were statistically significant (P<0.05). In the observation group, the frequency of additional pressure on postoperative analgesia pump was less than that in the control group, and the interval of additional pressure was longer than that in the control group, the differences were statistically significant (P<0.05). Conclusion For breast cancer patients undergoing modified radical mastectomy,the application of ultrasound -guided thoracic wall nerve block can provide definite analgesic effects, reduce postoperative opioid dosage, and improve the quality of resuscitation after anesthesia.
2021 Vol. 28 (3): 168-170转174 [Abstract] ( 33 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
171 Application value of multi-slice spiral CT multi-phase scanning in the diagnosis of pancreatic cancer
LI Li-xin RUAN Jin-rong FENG Bang-qiang
Objective To investigate application value of multi-slice spiral CT multi-phase scanning in the diagnosis of pancreatic cancer. Methods A total of 60 patients with detected pancreatic masses who were admitted to Yangjiang Hospital of Traditional Chinese Medicine from June 2015 to June 2019 were selected as study subjects. All of them received multi-slice spiral CT and ultrasonography, with that result of surgical pathology examination as the gold standard. The diagnostic value of the two methods, as well as the CT value of three-phase spiral CT scan in patients with pancreatitis and pancreatic cancer were compared. Results The staging accuracy of multi-slice spiral CT examination method was higher than that of ultrasonography, the difference was statistically significant (P<0.05). The low staging rate and the high staging rate of multi-slice spiral CT were lower than those of ultrasonography, the differences were statistically significant (P<0.05). The accuracy and the specificity of the multi-slice spiral CT examination method were higher than those of the ultrasonography, the differences were statistically significant (P<0.05). The CT values of arterial phase scan, portal phase scan and delayed phase scan in the pancreatic cancer group were higher than those of the pancreatitis group, the differences were statistically significant (P<0.05). Conclusion The value of multi-slice spiral CT in the diagnosis of pancreatic cancer is accurate, which can provide effective reference for clinical diagnosis and treatment plans.
2021 Vol. 28 (3): 171-174 [Abstract] ( 50 ) HTML (34 KB)  PDF  (0 KB)  ( 5 )
175 Effect evaluation of CT scan and air enema for diagnosis and reduction of intussusception in children
ZHOU Wen-bin； WANG Li-li
Objective To investigate the effect evaluation of CT plain scan and air enema on diagnosis and reduction of intussusception in children. Methods A total of 80 cases of children intussusception who were admitted to Quanzhou Women′s and Children′s Hospital from April 2018 to April 2020 were selected as the research subjects. They were divided into the observation group and the control group according to the random number table, with 40 cases in each group. The observation group underwent plain CT scan with GE 64-slice spiral CT scanner, and acquired image data for thin-layer reconstruction, which was transmitted to ADW4.3 workstation for multiplanar reconstruction. The control group underwent air enema with Toshiba′s 500 mA gastrointestinal imaging camera. Foley tube balloon was inflated and then placed into anus, and then connected to the reducer, and the gas was injected slowly from the lowest pressure. All the above results were diagnosed by two imaging physicians with deputy senior professional titles. The preparation time before examination and the examination process time were compared between the two groups. The success rate of reduction and the incidence of intestinal perforation were compared between the two groups. The treatment reduction time and hospitalization time after treatment were compared. Results The preparation time and examination process time in the observation group were shorter than those of the control group, the differences were statistically significant (P<0.05).the reduction success rate of the observation group was higher than that of the control group, and the incidence rate of intestinal perforation was lower than that in the control group, the differences were statistically significant (P<0.05). The treatment reduction time and hospitalization time of the observation group were shorter than those of the control group the differences were statistically significant (P<0.05). Conclusion For children intussusception, CT plain scan reduction has high diagnostic efficiency, simple operation, high reduction success, few complications and high safety.
2021 Vol. 28 (3): 175-177 [Abstract] ( 43 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
178 Clinical effect of anal sinus resection release combined with fumigation and washing with Baishao Qiwu Granules in the treatment of anal sinusitis
CHEN Zheng-shi； HE Yong-heng
Objective To observe the clinical effect of anal sinus resection release combined with fumigation and washing with Baishao Qiwu Granules in the treatment of anal sinusitis. Methods From October 2018 to October 2019,80 patients with anal sinusitis admitted to the Department of Anorectal of the Second Affiliated Hospital of Hu′nan University of Chinese Medicine were selected as the research objects. According to the random number table method,they were divided into the treatment group and the control group, 40 cases in each group. Patients in the treatment group were treated with anal sinus resection release, followed by fumigation and washing with Baishao Qiwu Granules.Patients in the control group were treated with anal sinus incision, and Puji Hemorrhoids Suppository after the operation was used in anus. The clinical efficacy, anal pain degree and wound healing time of the two groups were compared.Results The anal pain degree of the treatment group was lighter than that of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the wound healing time between the two groups(P>0.05). The total effective rate of treatment in the treatment group was 100.00%, which was higher than 85.00% in the control group, and the difference was statistically significant (P<0.05). Conclusion Anal sinus resection release combined with fumigation and washing with Baishao Qiwu Granules has a good clinical effect in the treatment of anal sinusitis.
2021 Vol. 28 (3): 178-181 [Abstract] ( 43 ) HTML (37 KB)  PDF  (0 KB)  ( 8 )
182 Effect of Zishen Yutai Pills combined with Clomifene Citrate on endometrial receptivity and pregnancy outcome in patients with kidney deficiency type of unexplained infertility
MA Yao； LI Hui； YANG Li ；SUN Han-bing
Objective To investigate the effect of Zishen Yutai Pills combined with Clomifene Citrate on endometrial receptivity and pregnancy outcome in patients with kidney deficiency type of unexplained infertility. Methods The clinical data of 98 patients with kidney deficiency type of unexplained infertility who were treated in Dalian Maternal and Child Health Care Hospital from January 2017 to January 2019 were retrospectively analyzed. The patients were divided into groups according to different treatment methods, 49 patients with Clomifene Citrate were included in the control group, and 49 patients with Clomifene Citrate combined with Zishen Yutai Pills were included in the observation group. The endometrial receptivity (endometrial thickness and type-A endometrial morphology rate), ovarian reserve function (estradiol [E2], follicle-stimulating hormone [FSH], luteinizing hormone [LH]) and pregnancy outcome(preganncy, live birth, abortion) were compared between two groups before and after treatment. Results The endometrial thickness and type-A endometrial morphology rate in two groups after treatment were higher than those before treatment, and the differences were statistically sighificant (P＜0.05); after treatment, the endometrial thickness and type-A endometrial morphology rate in the observation group were higher than those in the control group, and the differences were statistically sighificant (P＜0.05). The levels of serum E2, FSH and LH in two groups after treatment were higher than those before treatment, and the differences were statistically sighificant (P＜0.05); after treatment, the levels of serum E2, FSH and LH in the observation group were higher than those in the control group, and the differences were statistically sighificant (P＜0.05). The pregnancy rate and live birth rate in the observation group were higher than those in the control group, and the abortion rate in the observation group was lower than that in the control group, and the differences were statistically significant (P＜0.05). Conclusion Zishen Yutai Pills combined with Clomifene Citrate for patients with kidney deficiency type of unexplained infertility can regulate endometrial receptivity and improve ovarian reserve function.
2021 Vol. 28 (3): 182-184转188 [Abstract] ( 41 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
185 Effect analysis of combined traditional Chinese and western medicine in treatment of phlegm-damp accumulation in the lung syndrome of community-acquired pneumonia
WU Xia ；PENG Xue-ming
Objective To explore the effect of combined traditional Chinese and western medicine in treatment of phlegm-damp accumulation in the lung syndrome of community-acquired pneumonia (CAP). Methods A total of 60 patients with phlegm-damp accumulation in the lung syndrome of CAP who were admitted to Yichun Traditional Chinese Medicine Hospital from November 2018 to December 2019 were divided into two groups according to random number table method, with 30 cases in each group. Control group was given routine western medicine, and treatment group was treated with modified Erchen Decoction and point application based on control group, both groups were treated continuously for 10 days. The clinical efficacy, scores of major and secondary syndromes of TCM syndromes,and C-reactive protein (CRP) levels between the two groups were compared. Results The total clinical effective rate of treatment group was higher than that of control group, the difference was statistically significant (P＜0.05); after treatment, the scores of main symptoms and secondary symptoms of TCM syndromes in both groups were lower than those before treatment, and the treatment group was lower than the control group, the differences were statistically significant(P＜0.05); the levels of CRP in two groups after treatment were lower than those before treatment, and treatment group was lower than control group, the differences were statistically significant (P＜0.05). Conclusion The combined treatment of CAP with traditional Chinese and western medicine is better than conventional western medicine, improves clinical symptoms and pulmonary inflammation, and is conducive to patient recovery. It is worthy of clinical application.
2021 Vol. 28 (3): 185-188 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 5 )
189 Effect of integrated traditional Chinese and Western medicine in the treatment of diabetic foot infection and its influence on serum inflammatory factors
LI Wei ；YANG Cai-yun
Objective To explore the effect of integrated traditional Chinese and Western medicine in the treatment of diabetic foot infection and its influence on serum inflammatory factors. Methods A total of 178 patients with diabetic foot infection admitted to Nanchang Hongdu Hospital of Traditional Chinese Medicine from February 2018 to March 2020 were selected as the research subjects,and they were divided into the control group(n=89)and the observation group(n=89) by the random number table method. The control group was treated with Western medicine, and the observation group was treated with integrated traditional Chinese and Western medicine. After 1 month of treatment, the treatment effect of patients was evaluated. The postoperative recovery time, traditional Chinese medicine syndrome scale score,dorsal foot artery diameter, blood flow velocity, vascular cell adhesion molecule 1 (VCAM-1), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) levels before and after treatment were compared between the two groups. Results After treatment, the time of granulation tissue growth, foot ulcer debridement and epithelial tissue formation in the observation group were faster than those in the control group, the differences were statistically significant (P<0.05). There were no significant differences in the score of traditional Chinese medicine syndrome scale,dorsal foot artery diameter and blood flow velocity between the two groups before treatment (P>0.05). After treatment,the scores of traditional Chinese medicine syndrome scale and blood flow velocity of the two groups were lower than those before treatment, and the dorsal foot artery diameter was increased compared with that before treatment, the differences were statistically significant (P<0.05). After treatment, the score of traditional Chinese medicine syndrome scale and the blood flow velocity of the observation group were lower than those of the control group, and the diameter of the dorsal foot artery was higher than that of the control group, the differences were statistically significant (P<0.05).Before treatment, there were no significant differences in serum inflammatory factor levels between the two groups (P>0.05). The levels of serum inflammatory factors in the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P<0.01). The levels of serum inflammatory factors in the observation group after treatment were lower than those in the control group, and the differences were statistically significant (P<0.01). Conclusion The combination of traditional Chinese and Western medicine is effective in treating diabetic foot infection. It can promote the rehabilitation of the patients′ limbs, relieve the symptoms, improve the diameter of the dorsal artery of the foot, speed up blood flow, and significantly reduce the level of inflammatory factors in the patients,thereby promoting the recovery of inflammation. It is of great significance to the treatment of diabetic foot infection, and it is worthy of promotion and applicatio
2021 Vol. 28 (3): 189-192 [Abstract] ( 45 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
193 Effect of integrated traditional Chinese and Western medicine therapy on functional recovery of patients with stroke sequela
TANG Lin
Objective To analyze the effect of integrated traditional Chinese and Western medicine therapy on functional recovery of patients with stroke sequelae. Methods From February 2019 to February 2020, 80 patients with stroke sequelae treated in Liaoning Disabled Service Center were selected as the research objects, and they were divided into the treatment group (40 cases) and the control group (40 cases) according to the random number table method. The control group was given conventional medical treatment and physical therapy, while the treatment group was given oral Chinese medicine, acupuncture, herbal fumigation and other treatment on the basis of the control group. After 3 months,the therapeutic effect was evaluated and the scores of Fugl-Meyer and function independent measure (FIM) before and after treatment were compared between the two groups. Results The therapeutic effect of the treatment group was better than that of the control group (P<0.05). The total effective rate of the treatment in the treatment group was 95.0%, and that of the control group was 77.5%. The total effective rate of the treatment in the treatment group was higher than that in the control group, the difference was statistically significant (P<0.05). The scores of Fugl-Meyer and FIM of the two groups after treatment were higher than those before treatment, the differences were statistically significant (P<0.05).After treatment, the scores of Fugl-Meyer and FIM in the treatment group were higher than those in the control group,the differences were statistically significant (P<0.05). Conclusion The effect of integrated traditional Chinese and Western medicine therapy on stroke sequelae is more accurate, which can promote the recovery of function and improve the ability of self-care.
2021 Vol. 28 (3): 193-195转199 [Abstract] ( 36 ) HTML (36 KB)  PDF  (0 KB)  ( 8 )
196 Analysis of traditional Chinese medicine constitution of asthmatic children in remission stage
LENG Ling； HUANG Yan
Objective To analyze the distribution law of traditional Chinese medicine (TCM) constitution in asthmatic children in remission stage, for providing a theoretical basis for children with asthma remission seeking individualized intervention methods of TCM. Methods A total of 212 children with asthma in remission stage who visited Dalian Children′s Hospital from January 2018 to January 2020 were selected for TCM constitution evaluation as the remission stage group, and 100 healthy children in the same period were selected for comparison as the healthy group. The distribution difference of TCM constitutions was compared between the two groups. Results The TCM constitutions of children in remission stage of asthma had certain commonness, and most of them were biased constitutions, 3-6 years old children with asthma in remission stage of bias mainly lung insufficiency, special essential quality, stomach strong spleen deficiency, and the differences were statistically significant compared with healthy children (P<0.05). The common biased constitutions of 7-14 years old children with asthma in remission stage were special intrinsic quality, qi deficiency quality and qi stagnation quality, among which the differences were statistically significant compared with the healthy group (P<0.05). Conclusion The types of TCM constitutions in asthmatic children in remission stage are mainly biased, and the types of biased constitutions are different in different age stages. In the clinical treatment, the TCM constitution of children with asthma should be considered comprehensively.
2021 Vol. 28 (3): 196-199 [Abstract] ( 44 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
200 Study on association between serum liver enzymes and metabolic syndrome
WU Di-yun； CHEN Yan-hong； TANG Jian-hui
Objective To explore the association between serum liver enzymes and metabolic syndrome (MS). Methods A total of 2232 people who had physical examination in the Physical Examination Center of Qingyuan People′s Hospital were selected as study subjects from January to December 2019. They were divided into MS group and non-MS group according to whether they had MS or not. The levels of liver enzymes were compared between the two groups, the correlation of three liver enzymes with MS and its components, and their screening effect on MS were analyzed. Results There were 586 cases in the MS group and 1646 cases in the non-MS group, and the prevalence of MS in the study population was 26.25%. The liver enzyme level of MS group was higher than that of non-MS group, the difference was statistically significant (P＜0.05). In female, alanine aminotransferase (ALT) was associated with waist circumference and serum triglyceride (TG), while γ-glutamyl transferase (GGT) was associated with fasting blood glucose and TG. In male,ALT was associated with waist circumference, diastolic blood pressure and high-density lipoprotein cholesterol, while GGT was associated with waist circumference, TG and diastolic blood pressure (|r|＞0.2, P＜0.05). There was significant correlation between the MS risk and the levels of ALT and GGT in male, and GGT in female (P＜0.05). GGT could be used to screen the MS, and the possibility best critical values were respectively 15.5 U/L in female and 28.5 U/L in male. Conclusion Among the three liver enzymes, GGT has the closest relationship with MS, and GGT can better screen the possibility of MS disease.
2021 Vol. 28 (3): 200-203 [Abstract] ( 46 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
204 Analysis of adverse factors affecting male pre-pregnancy eugenics health status
ZHUANG Xiao-bin
Objective To explore the adverse influencing factors of male pre-pregnancy eugenic health status. Methods A total of 6156 men who underwent pregnancy test admitted to Maternal and Child Health Hospital of Xiamen Tong′an District from March 13, 2016 to March 15, 2020 were selected as the research subjects, all the clinical data were investigated to analyze the adverse influencing factors of male pre-pregnancy eugenic health status. Results There were 2845 male patients with abnormal results, which was the abnormal result group, and 3311 healthy patients, which was the healthy condition group. There were statistically significant differences between the two groups in terms of reproductive diseases, poor working environment, history of alcohol consumption, smoking, education and age (P<0.05).The main adverse factors affecting male pre-pregnancy health status were age≥36 years old, reproductive system disease, poor working environment, history of drinking, smoking, junior middle school education or below. Conclusion Educational background, living habits, environment, reproductive system diseases, and age are the main factors leading to male eugenic health status before pregnancy. Therefore, it is necessary to regulate their living habits and emphasize the importance of eugenic examination before pregnancy, so as to promote eugenics and childbearing and prevent Birth defects.
2021 Vol. 28 (3): 204-206 [Abstract] ( 34 ) HTML (29 KB)  PDF  (0 KB)  ( 8 )
207 Correlation analysis of drug resistance rate of Klebsiella pneumoniae and use of antibiotics in Taizhou Third People′s Hospital from 2017 to 2019
CAI Xia
Objective To analyze the correlation between the drug resistance rate of Klebsiella pneumoniae (KPN) and the use intensity of antibiotics (AUD) in Taizhou Third People′s Hospital (hereinafter referred to as "our hospital") in recent years. Methods A total of 611 KPN strains were isolated from 115 102 specimens in our hospital from January 2017 to December 2019 were collected as the research objects. The drug resistance rate of KPN and common AUD were calculated to analyze the correlation between them. Results The detection rate of production of extended spectrum β-lactamase (ESBLs) KPN increased year by year. Cefuroxime and Levofloxacin were top two antibiotics with the highest AUD in three years. There was no significant correlation between the drug resistance rate of KPN and AUD of Cefuroxime, Piperacillin Tazobactam, Meropenem and Imipenem (P＞0.05). The drug resistance rate of KPN was negatively correlated with AUD of Amikacin and Tobramycin (r=-0.610, -0.767; P<0.05). The drug resistance rate of KPN was positively correlated with AUD of Ceftazidime (r=0.629; P＜0.05). Conclusion There is a certain correlation between the drug resistance of KPN and the AUD. Antimicrobial agents should be selected scientifically to reduce drug resistance rate of KPN.
2021 Vol. 28 (3): 207-209 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
210 Enlightenment of the Holland RAP model on promoting the sexual and reproductive health level in adolescents in China
XU Xiao-yan；ZHANG Zhuo-yu
The Holland RAP reproductive health model aims to make adolescents to form correct sexual and reproductive health concept, improve their ability and level of sexual and reproductive health, and facilitate safe and healthy growth by facing up to adolescents′ sexual behaviors, taking rights and knowledge as the basis, and taking service protection and participation as the guarantee. It is of great significance to build a good policy environment for open-minded treatment of sexual and reproductive health education, promote the right awareness of sexual and reproductive health of adolescents, implement the general education of sexual and reproductive health of adolescents, and promote adolescents to become the masters of health actions.
2021 Vol. 28 (3): 210-214 [Abstract] ( 33 ) HTML (44 KB)  PDF  (0 KB)  ( 6 )
215 Application effect of risk management concept in nursing safety management of the department of psychiatry
HUANG Yun-fang ；ZHOU Zhi-xiang ；ZOU Song-ting
Objective To explore the application effect of risk management concept in nursing safety management of the department of psychiatry. Methods A total of 80 patients with psychiatric diseases admitted to Mental Hospital of Guangzhou Civil Affairs Bureau from February 2018 to February 2019 were selected as the research objects, and they were divided into the control group (40 cases) and the test group (40 cases) according to the random number table method. The control group adopted the conventional nursing model, and the test group adopted the risk management concept mode. The incidence of accidents and the total satisfaction of family members to nursing were compared between the two groups. Results The total incidence of accidents in the test group was 10.00%, which was lower than that in the control group (32.50%), the total nursing satisfaction of family members in the test group was 92.50%, which was higher than that in the control group (70.00%), the differences were statistically significant (P＜0.05). Conclusion The application of risk management concept in the nursing safety management of the department of psychiaty can not only reduce the occurrence of accidents, but also improve the satisfaction of family members to nursing work.
2021 Vol. 28 (3): 215-217转224 [Abstract] ( 40 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
218 Reflections on strengthening the party′s construction work and the management of the party members in the hospital under the new situation
GU Jun
Party building by thought and culture building are the main lifeblood of party′s construction work. The hospital regards cultural construction as the core driving force of sustainable development, always puts it in an important position, insists on long-term unremitting efforts, and under the guidance of the party′s construction work, the hospital′s work can be promoted effectively, and can provide people with high-quality medical services. Under the new situation,hospital party′s construction work and management of party members face new challenges. If the party′s construction is solid, it is productivity, if it is strong, it is competitive, and if it is detailed, it is cohesion. Therefore, strengthening the party′s construction work and the management of the party members in the hospital has important practical significance for improving the comprehensive service capacity of the hospital.
2021 Vol. 28 (3): 218-220转231 [Abstract] ( 41 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
221 One case of large rectal foreign body incarcerated
ZHOU Wan-jing； TANG Zhi-jun
Anorectal foreign body is an injury disease of the intestinal wall and surrounding tissues caused by many factors, which is rare in clinic. The main clinical manifestations are defecation disorders, obstruction, pain, bleeding,etc., or even a series of complications such as perforation, peritonitis or abscess formation. The incarcerated anorectal foreign body should be operated as soon as possible once diagnosed, and the complications should be actively managed to improve the cure rate. Most anorectal foreign bodies are related to sexual masturbation. Through retrospective analysis of a case of incarceration of huge rectal foreign bodies caused by masturbation behavior, this paper discusses the individual treatment of incarceration of anorectal foreign bodies caused by masturbation, summarizes the main points of diagnosis and treatment, and shares relevant clinical experience.
2021 Vol. 28 (3): 221-224 [Abstract] ( 32 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
225 Analysis of 2 cases of acute immune thrombocytopenia after vaccination
GAO Dong-mei ；ZHU Li-jun ；DONG Gui-hua
Two cases of acute immune thrombocytopenia after vaccination were collected and analyzed. The condition of case 1 was consistent with the clinical symptoms of acute immune thrombocytopenia caused by cytomegalovirus infection, and laboratory tests suggested cytomegalovirus infection, which was not associated with the time of vaccination,and is defined as a coincidental event of vaccination. In case 2, the acute immune thrombocytopenia was associated with the time of vaccination, and there was no other cause, which was an abnormal response to vaccination. It is suggested that the acute immune thrombocytopenia occurring after vaccination should be judged according to the specific situation of the patient, one kind may be the abnormal reaction of vaccination, and the other may be the coincidence of vaccination. In the future, the contraindication should be paid attention to reduce the incidence of coincidental event.
2021 Vol. 28 (3): 225-227 [Abstract] ( 43 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
228 Risk assessment and nursing strategy of postoperative lung infection physiology and surgical severity scoring system
HU Ting ；XIA Hui-hua ；ZHU Xian-hua
Objective To explore risk assessment and nursing strategies of the postoperative lung infection physiology and surgical severity scoring system (POSSUM). Methods The data of 80 middle-aged and elderly patients who underwent surgical treatment in the Third People′s Hospital of Jiujiang City, Jiangxi Province from January 2019 to March 2020 were retrospectively analyzed. 40 patients who underwent general surgery routine care from January to August 2019 were included in the control. In the observation group, 40 patients who used the POSSUM score-based lung infection grading preventive care strategy from September 2019 to March 2020 on the basis of routine care were included in the observation group. The nursing time of both groups was 1 month, acute physiology and chronic health score Ⅱ (APACHEⅡ), incidence of lung infection after nursing, and total nursing satisfaction were compared between the two groups. Results After 1 month of nursing, the APACHE Ⅱscore of the observation group was lower than that of the control group, the total incidence of lung infection was 2.50% (1/40), was lower than that of the control group of 20.00% (8/40), and total satisfaction was 97.50%, higher than that of the control group of 77.50%, the differences were statistically significant (P<0.05). Conclusion The use of POSSUM for surgical patients to assess postoperative risks and formulate targeted grading nursing plans based on the assessment results can significantly reduce the risk of postoperative lung infections, and significantly improve the prognosis and patient satisfaction, which has promotion value.
2021 Vol. 28 (3): 228-231 [Abstract] ( 55 ) HTML (35 KB)  PDF  (0 KB)  ( 7 )
232 Effect of cluster nursing intervention on ICU artificial airway patients
LIANG Yan-zhen； LIANG Qian； HUANG Cai-yun
Objective To explore the effect of cluster nursing intervention on patients with artificial airway in ICU.Methods A total of 120 patients with artificial airway treated in Yangdong District People′s Hospital of Yangjiang City,Guangdong Province from December 2017 to December 2018 were selected as the research objects, and they were divided into two groups using the digital parity method, 60 cases in each group. The control group used conventional nursing method, the observation group used cluster nursing intervention method. The hospitalization time, mechanical ventilation time, complications, and satisfaction with nursing care of the two groups were compared. Results Hospitalization time and mechanical ventilation time of the observation group were shorter than those of the control group, and the differences were statistically significant (P<0.05). The total complication rate of the observation group was 1.67%,which was lower than that in the control group of 11.67%, the difference was statistically significant (P<0.05). The total satisfaction nursing of the observation group was 95.00%, which was higher than that of the control group of 73.33%,and the difference was statistically significant (P<0.05). Conclusion The application of cluster nursing intervention for patients with artificial airway in ICU can reduce the length of hospitalization and mechanical ventilation, reduce the risk of complications, and make patients more satisfied, which has clinical application value.
2021 Vol. 28 (3): 232-234 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
235 Application value of comprehensive nursing in clinical nursing of patients with autoimmune encephalitis
SHI Xue ；FENG Yan
 Objective To explore the application value of comprehensive nursing in clinical nursing of patients with autoimmune encephalitis （AE）. Methods A total of 90 patients with AE admitted to Shenyang First People′s Hospital,Liaoning Province from June 2016 to October 2019 were selected as the research objects, and were divided into control group (45 cases) and observation group (45 cases) according to the order of patients′ admission treatment. Both groups received intravenous immunoglobulin. The control group adopted routine nursing and comprehensive nursing was used in the observation group. The nursing satisfaction, nursing quality and cognitive dysfunction before and after nursing were compared between the two groups. Results The nursing total satisfaction and nursing quality (basic care, professional care, nursing safety and nursing quality) scores of the observation group were higher than those of the control group, and the differences were statistically significant (P<0.05). The cognitive dysfunction score before nursing between the two groups was not statistically significant (P＞0.05). The intelligence quotient (IQ) and memory quotient (MQ)scores in observation group after nursing were higher than those of the control group, and the degree of brain lesion(DQ) score was lower than that of the control group, the differences were statistically significant (P<0.05). Conclusion Comprehensive nursing can improve the satisfaction and quality of care of patients with AE, improve cognitive function obviously, and have high value in popularization and application.
2021 Vol. 28 (3): 235-237 [Abstract] ( 38 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
238 Discussing the construction of traditional Chinese medicine nursing conceptual framework of ″strength spleen and stomach″ based on ontology technology
WENG Mei-hua； CHEN Jin-xiu； HU Jing-wen ；FAN Li-min； ZHANG Hong-xin； ZHOU Hong-juan
 As a conceptual model modeling method and idea, ontology is a conceptual model modeling tool that can describe the system from two aspects of knowledge level and semantics, and can derive conceptual organization with theoretical evidence. Its commonly used development tool is Protégé. The thought of ″strength spleen and stomach″ has important guiding significance for the clinical diagnosis, treatment and regulation of traditional Chinese medicine(TCM). The establishment of a conceptual framework of TCM nursing with ″strength spleen and stomach″ as the core will help enrich the ideological connotation of ″strength and stomach″. The article analyze the research status of ″strength spleen and stomach″ TCM nursing thinking and finds that there is no report on the construction of ″strength spleen and stomach″ TCM nursing conceptual framework. Therefore, combining the current research status and conceptual framework construction methods, the framework construction ideas are proposed. It is planned to use holistic nursing concepts and dialectical nursing as guidance, from disease observation, daily life nursing, medication nursing, diet nursing,emotional nursing, preventive nursing, and digging out the content of traditional Chinese medicine nursing care of the "strength spleen and stomach", clarifying the relationship between concepts and constructing. The conceptual framework of TCM, nursing care with clear concepts, standardized expressions and clear levels is intended to be used to guide clinical nursing work.
2021 Vol. 28 (3): 238-240 [Abstract] ( 41 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
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