PI3K/AKT信号通路与miR-203在食管癌中的研究进展

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Abstract

Esophageal cancer is a malignant tumor originating from the esophageal epithelium with complex pathogenesis. In esophageal cancer, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) is one of the signaling pathways involved and often activated, its abnormal activation can promote the development of esophageal cancer. The miR-203 is a small non-coding RNA molecule generally 19-22 nucleotides in length, with abnormal expression in multiple malignant tissues. The miR-203 regulates gene expression at the post-transcriptional level by binding to the 3′UTR of the target gene, which is closely related to the tumor development process. In recent years, many literatures report that miR-203 can influence the expression of related genes through PI3K/AKT pathway, thus affecting the proliferation,apoptosis, invasion and migration of esophageal cancer cells, which is related to the progression of esophageal cancer,clinical treatment and prognosis of patients.

Key words： Esophageal cancer PI3K/AKT Signaling pathway miR-203

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	Articles by authors
	HUANG Hui
	YIN Cai-qiao
	CHEN Ting

Cite this article:

HUANG Hui,YIN Cai-qiao,CHEN Ting. Research progress of PI3K/AKT signaling pathway and miR-203 in esophageal cancer[J]. 中国当代医药, 2021, 28(3): 29-33.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I3/29

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