西那卡塞联合高通量透析治疗中重度继发性甲状旁腺功能亢进的临床研究

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Abstract Objective To study the clinical effect of Cinacalcet combined with high-throughput dialysis (HFD) in the treatment of moderate to severe secondary hyperparathyroidism （SHPT）. Methods Eighty patients with moderate to severe SHPT admitted to Hangzhou Xiaoshan District First People′s Hospital, Zhejiang Province from February 2018 to February 2020 were selected as the research objects. According to the random number table method, they were divided into the experimental group (40 cases) and the control group (40 cases). The control group used HFD, and the experimental group used Cinacalcet+ HFD. The thyroid length, width, thickness, volume and biochemical index levels of the two groups were compared. Results Before treatment, there were no significant differences in thyroid length, width,thickness and volume between the two groups (P＞0.05). After treatment, the thyroid length, width, thickness, and volume of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). The thyroid length, width, thickness, and volume of the experimental group after treatment were lower than those of the control group, and the differences were statistically significant (P<0.05). Before treatment, there were no significant differences in the levels of biochemical indexes between the two groups (P＞0.05). The serum calcium content of the control group after treatment was higher than that before treatment, the serum calcium of the experimental group after treatment was lower than that before treatment, and the contents of phosphorus, immunoreactive parathyroid hormone (iPTH) and serum alkaline phosphatase (ALP) in two groups after treatment were lower than those before treatment, and the differences were statistically significant (P<0.05). The serum calcium, phosphorus, iPTH and ALP contents of the experimental group after treatment were lower than those of the control group, and the differences were statistically significant (P<0.05). Conclusion Cinacalcet combined with HFD can more effectively control blood calcium, blood phosphorus, blood alkaline phosphatase, blood PTH levels and thyroid in patients with moderate to severe mineral and abnormal bone metabolism hyperplasia of parathyroid glands.

Key words： Cinacalcet High-throughput dialysis Secondary hyperparathyroidism

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	Articles by authors
	YU Jian-gen
	YANG Ai-hua
	ZHANG Xiao-yun
	SHEN Li-jun
	ZHU Hua

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YU Jian-gen,YANG Ai-hua,ZHANG Xiao-yun, et al. Clinical study of Cinacalcet combined with high-throughput dialysis in the treatment of moderate to severe secondary hyperparathyroidism[J]. 中国当代医药, 2021, 28(3): 45-47.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I3/45

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