|
|
|
| Effect of high-flux dialysis combined with hemoperfusion on inflammatory factors and quality of life in elderly chronic renal failure maintenance hemodialysis patients |
| GUAN Xing-ye |
| Department of Nephrology, Liaoyang Infectious Diseases Hospital |
|
|
|
|
Abstract Objective To explore the effect of high-flux dialysis combined with hemoperfusion on inflammatory factors and quality of life in elderly chronic renal failure maintenance hemodialysis patients. Methods A total of 152 patients with chronic renal failure who were admitted to Liaoyang Infectious Diseases Hospital of Liaoning Province from May 2017 to November 2019 were selected as the research objects and divided into the control group and the observation group according to the random number table method, with 76 cases in each group. The control group was treated with high-flux dialysis, and the observation group was treated with high-flux dialysis combined with hemoperfusion. Both groups were treated continuously for 2 months. The levels of blood calcium, blood phosphorus, intact parathyroid hormone (iPTH), inflammatory factors and quality of life were compared between the two groups. Results There were no statistically significant differences in levels of blood calcium, blood phosphorus and iPTH of the two groups before treatment (P>0.05). After 2 months of treatment, the blood calcium and iPTH levels of the two groups were lower than those before treatment, the blood phosphorus levels were higher than those before treatment, and differences were statistically significant (P<0.05). After 2 months of treatment, the blood calcium and iPTH levels of the observation group was lower than that of the control group, the blood phosphorus levels were higher than those of the control group, and differences were statistically significant (P<0.05). There were no statistically significant differences in interleukin-6(IL-6) and tumor necrosis factor-α (TNF-α) between the two groups before treatment (P>0.05). After 2 months of treatment, the levels of IL-6 and TNF-α in the two groups were lower than those before treatment, and differences were statistically significant (P<0.05). After 2 months of treatment, the levels of IL-6 and TNF-α in the observation group were lower than those in the control group, and the differences were statistically significant (P<0.05). There was no statistically significant difference in general quality of life inventory (GQOLI-74) score between the two groups before treatment (P>0.05). After 2 months of treatment, the GQOLI-74 scores of the two groups were higher than those before treatment, and the differences were statistically significant (P<0.05). After 2 months of treatment, the GQOLI-74 score of the observation group was higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion High-flux dialysis combined with hemoperfusion for senile chronic renal failure patients with maintenance hemodialysis can improve calcium-phosphorus metabolism disorder and iPTH secretion disorder, decrease inflammatory state and increase quality of life, which has better clinical efficacy.
|
|
|
|
|
|
| [1] |
缪蕙，刘芳，刘玺，等.高通量血液透析对老年维持性血液透析患者营养状况的影响研究[J].中国当代医药，2018，25（3）：42-44.
|
| [2] |
罗媛媛，李祯，闫焱.慢性肾衰竭患者维持性血液透析前后眼轴及眼前节生物学参数的变化[J].中华航海医学与高气压医学杂志，2019，26（4）：324-327.
|
| [3] |
邱君飞，吴广宇，姚风良，等.不同透析方式对慢性肾衰竭尿毒症患者微炎症状态的影响[J].中国医刊，2019，54（3）：338-340.
|
| [4] |
湖南省医院协会.临床疾病诊断与疗效判断标准[M].北京：科学技术文献出版社，2010：261.
|
| [5] |
房文杰.慢性心衰患者生活质量和心血管不良事件的影响因素分析[D].济南：山东大学，2018.
|
| [6] |
王慧敏.名老中医段光堂治疗慢性肾衰病临床经验总结[J].中国中西医结合肾病杂志，2019，20（2）：150-151.
|
| [7] |
吕彬，唐曦，李雪梅.血液透析和腹膜透析对慢性肾衰竭患者平均血小板体积和炎症相关因子的影响[J].中国中西医结合肾病杂志，2019，20（2）：139-141.
|
| [8] |
赖冬梅，王燕涛.长期血液透析对慢性肾衰竭患者肾性贫血、营养状态及炎症因子水平的影响[J].标记免疫分析与临床，2019，26（7）：1150-1154.
|
| [9] |
陈波.不同透析方式对慢性肾衰竭肾性骨病患者成纤维细胞生长因子23、钙磷及炎症因子的影响[J].中国老年学杂志，2019，39（2）：333-336.
|
| [10] |
王萌，蒋红利，何荃，等.血液透析联合血液灌流治疗对慢性肾衰竭患者肾功能、微炎症状态和血液净化效果的影响[J].现代生物医学进展，2018，18（8）：1511-1514，1413.
|
| [11] |
邵秋媛，张苗，张庆燕，等.血液透析和腹膜透析对慢性肾衰竭患者微炎症状态和生活质量影响的临床研究[J].现代生物医学进展，2018，18（13）：2478-2482.
|
| [12] |
刘继红，弓晓丽，张利霞，等.高通量透析对尿毒症患者炎性因子及血脂代谢的影响[J].中国药物与临床，2019，19（24）：4373-4374.
|
| [13] |
班遵浦，罗国鸿，陈彤.高通量透析的效果及对患者生存率的影响[J].中国现代医学杂志，2017，27（11）：125-128.
|
| [14] |
赵建明，朱小华，牟爱华，等.血液灌流联合血液透析与左卡尼汀对慢性肾衰竭患者贫血和钙磷代谢及炎性因子的影响[J].中国临床研究，2018，31（7）：914-917.
|
| [15] |
黄小蝶.血液透析联合血液灌流在慢性肾衰竭患者中的应用效果及安全性分析[J].检验医学与临床，2018，15（8）：1165-1167.
|
|
|
|
