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2020 Vol. 27, No. 23
Published: 2020-08-18
 
 
4 Determination of four kinds of phenolic acid components in Cassia obtusifolia by ultra performance liquid chromatography-tandem mass spectrometry
BAI Yu-bing；LI Hong-quan；BAO Min
Objective To establish an ultra performance liquid chromatography-tandem mass spectrometry method for the determination of four phenolic acid components (chlorogenic acid, ferulic acid, protocatechuic acid and protocatechualdehyde) in Cassia obtusifolia.Methods Cassia obtusifolia was extracted by ultrasound with 50%methanol.Chromatographic separation was performed on Acclaim 120 C18 (150 mm×4.6 mm, 5 μm) column by gradient elution with the mobile phase consisted of 0.1% formic acid (A) and acetonitrile (B).The flow rate was 0.5 ml/min, the column temperature was 30℃, and the injection volume was 2 μl.The mass spectra was obtained by electron spray ionization (ESI) under negative ion mode.Results The linear ranges of chlorogenic acid, ferulic acid, protocatechuic acid and protocatechualdehyde fell into 0.0200-3.2000,0.0230-3.6800,0.0230-3.6800,0.0280-4.4800 μg/ml,respectively.The average recovery of chlorogenic acid,ferulic acid,protocatechuic acid and protocatechualdehyde was 96.8%, 99.2%,96.3%and 96.9%,respectively.The contents of chlorogenic acid,ferulic acid,protocatechuic acid and protocatechualdehyde were 85.691-304.280, 5048.3-139 69.0, 1458.2-9919.4 and 15.108-22.956 μg/g, respectively.Conclusion This method can be used for the determination of four phenolic acids in Cassia obtusifolia, which lays a foundation for the study on the dose-effect relationship of antioxidant activity of Cassia obtusifolia.
2020 Vol. 27 (23): 4-9 [Abstract] ( 35 ) HTML (55 KB)  PDF  (0 KB)  ( 7 )
10 Clinical significance of oxygen metabolic index in the evaluation of early acute renal injury in sepsis
YUAN Man-juan；HUO Bao-shan
Objective To explore the clinical significance of the ratio of the central venous-arterial carbon dioxide partial pressure difference and the arterial-central venous oxygen content difference (Pv-aCO2/Ca-vO2) to early acute renal injury (AKI) in sepsis.Methods This study was a prospective and observative cohort study.A total of 48 patients with sepsis and mechanical ventilation in the intensive care unit of Foshan Second People Hospital were enrolled into this study and their general clinical data grading scores were collected from August, 2019 to January, 2020.According to whether AKI occurred 24 h after resuscitation, they were divided into AKI group (n=31) and non-AKI group (n=17).The capillary refill time (CRT), lactate (Lac), Pv-aCO2 and Ca-vO2 were collected at 0, 12 and 24 h after resuscitation.The potential influencing factors of AKI were analyzed by binary Logistic regression model, and then the risk factors were decided.Receiver operating characteristic curve (ROC) was used to analyze the predictive value of each indexs for AKI diagnostic value at the early stage of sepsis.Results The initial score of acute physiology and chronic health and the initial score of sequential organ failure in AKI group were higher than those in the non-AKI group, the differences were statistic significant(P＜0.05).At 24 h after resuscitation, the Lac level in the AKI group was higher than that of the non-AKI group, and the difference was statistically significance(P＜0.05);At 12 and 24 h after resuscitation, the CRT of AKI group were longer than those of the non-AKI group, the differences were statistically significant(P＜0.05);At 0, 12 and 24 h after resuscitation, the Pv-aCO2/Ca-vO2 of the AKI group were higher than those of non-AKI group, the differences were also statistically significant (P＜0.05).The results of binary Logistic regression analysis showed that the value of Pv-aCO2/Ca-vO2 (β=2.579, OR=13.181, 95%CI=1.048-165.708, P=0.046) was an independent risk factor of AKI in early sepsis.ROC curve showed that 24 h after resuscitation, the cutoff value of Pv-aCO2/Ca-vO2 was 1.625,the sensitivity was 83.9% while the specificity was 76.5%.Conclusion Oxygen metabolism assessment has important clinical significance for early AKI assessment during resuscitation.Among them, Pv-aCO2/Ca-vO2 has a good predictive value for the progression of AKI.
2020 Vol. 27 (23): 10-13转20 [Abstract] ( 34 ) HTML (48 KB)  PDF  (0 KB)  ( 6 )
14 Expression and analysis of interleukin-21 and CC chemokine ligand 20 in atopic dermatitis mouse model
WANG Juan；ZHENG Ai-yi；BAO Hai-ping；ZHAO Yi-jin
Objective To detect the expression of interleukin-21 (IL-21) and CC chemokine ligand 20 (CCL20) in 2,4-dinitrochlorobenzene (DNCB) induced mice models with atopic dermatitis and explore their roles in the pathogenesis of atopic dermatitis.Methods Twelve female BALB/c mice were randomly divided into the model group and control group(6 in each).Mice models with atopic dermatitis were established by DNCB.After successful modeling, the serum levels of IL-21 and CCL20 were detected by enzyme-linked immunosorbent assay(ELISA).Results The serum levels of IL-21 and CCL20 in the model group with atopic dermatitis were significantly higher than those in the control group (P＜0.05).There was a positive correlation between the serum levels of IL-21 and CCL20 in the model group (r=0.59, P＜0.05).Conclusions The expression of IL-21 and CCL20 in the mouse model of atopic dermatitis is increased and positively correlated, which may be synergistically involved in the occurrence and development of atopic dermatitis.
2020 Vol. 27 (23): 14-16 [Abstract] ( 46 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
17 Association of biood uric with cardiovascular disease in patients with maintenance hemodialysis
LI Na
Objective To analyze the association of blood uric acid (UA) with cardiovascular disease inuremia patients receiving maintenance hemodialysis.Methods A total of 123 patients with chronic hepatic insufficiency maintenance hemodialysis who chose to visit our hospital from June 2018 to August 2019 were divided UA elevated group (n=78)and UA normal group (n=45) according to the UA normal reference value of 420 μmol/L as the cut-off point.Total cholesterol (TC), triglyeride (TG), low density cholesterol (LDL-C) and high-density cholesterol (HDL-C), serum creatinine (Scr) and blood urea nitrogen (BUN) were evaluated by automatic biochemistry analyser.Results Age, proportion of males, prevalence of hypertension, proportion of smokers, incidence of coronary heart disease after dialysis, Scr, UA,LDL-C, and TG in the elevated UA group were higher than those in the normal UA group, and the differences were statistically significant (P＜0.05);while HDL-C was lower than that in the UA normal group, the difference was statistically significant (P＜0.05).There were no significant differences in BMI, age, diabetes mellitus and TC between the two groups(P＞0.05).Logistic analysis showed that TG (β=1.582, OR=4.867, 95%CI=3.284-6.355), LDL-C (β=2.547, OR=12.766, 95%CI=10.576-15.423) and coronary heart disease after dialysis (β=2.207, OR=9.085, 95%CI=6.702-11.247)were the independent risk factors for the increase of serum uric acid (P＜0.05), among which LDL-C was more closely related.UA＞420 μmol/L (β=0.138, OR=1.148, 95%CI=1.002-1.303) and BUN (β=1.412, OR=4.105, 95%CI=2.695-5.587) were the risk factors of coronary heart disease after dialysis (P＜0.05), but UA＞420 μmol/L was more closely related to them.Conclusion Serum uric acid level in maintenance hemodialysis patients is a risk factor for cardiovascular disease in hemodialysis patients and is related to disorders of lipid metabolism
2020 Vol. 27 (23): 17-20 [Abstract] ( 42 ) HTML (37 KB)  PDF  (0 KB)  ( 6 )
21 Research status of chronic non-atrophic gastritis
XIAO Qiu-ping；LI Ying-meng；LIU Wen-jun
Chronic non-atrophic gastritis (CNG) is a common and frequently-occurring diseases, which seriously affects the quality of life of patients.What′s more, long-term recurrent relapse may develop into chronic atrophic gastritis, even transform into gastric cancer.Therefore, the prevention and therapy of CNG is particularly important.At present, the pathogenesis of CNG is not clear, and the symptoms are not specific.The main treatment is relieving the symptoms and improving the quality of life.Proton pump inhibitors and gastric mucosal protective agents are used most frequently in Western medicine, but the problems of some patients have not been solved due to the adverse reactions of long-term use and the compliance with long-term treatment.Traditional Chinese medicine mainly takes decoction,supplemented with external application such as acupoint application, which has good safety and efficacy.The combination of traditional Chinese and Western medicine has better efficacy used to treat CNG in clinic than Western medicine.This review describes the possible pathogenesis and clinical treatment of CNG, aimed at providing reference value for patients, doctors, nurses and researchers.
2020 Vol. 27 (23): 21-23转28 [Abstract] ( 44 ) HTML (38 KB)  PDF  (0 KB)  ( 6 )
24 Research progress of prognostic factors in locally advanced cervical cancer
HU Meng-ling；ZHAO Jing-sheng
Cervical cancer is one of the most common malignant tumors in women all over the world.It can be asymptomatic at the early stage, therefore, most patients are in the middle and advanced stages (in phase IB2-IV by FIGO stages) at the time of consultation.The first choice of synchronous radiotherapy and chemotherapy is recommended by guidelines for patients with locally advanced cervical cancer (LACC).Although the short-term efficacy is fair, numerous long-term follow-up data indicate that the long-term prognosis is poor and it is prone to recurrence and metastasis.Analytical investigation on the prognostic factors of LACC patients contributes to making the best individualized treatment plan according to the specific conditions of patients.It is of great significance to improve the survival rate and quality of life of patients with LACC.This paper offers an overview of age, history of human papillomavirus (HPV) infection, hemoglobin index, tumor stages and differentiation, and treatment modes, etc.
2020 Vol. 27 (23): 24-28 [Abstract] ( 38 ) HTML (48 KB)  PDF  (0 KB)  ( 6 )
29 Effect of Niaoduqing Granules combined with Febuxostat in the treatment of hyperuricemia
ZENG Bi-shan
Objective To explore the clinical effect of Niaoduqing Granules combined with Febuxostat in the treatment of hyperuricemia (HUA).Methods Forty HUA patients who treated in our hospital from June 2018 to September 2019 were selected as the research objects, and were divided into control group and observation group according to the random number table method, 20 cases in each group.The control group was treated with Febuxostat, and the observation group was treated with Niaoduqing Granules combined with Febuxostat.The clinical efficacy, laboratoryrelated indicators, quality of life, and adverse reactions of the two groups were observed.Results The total effective rate of the observation group (95.00%) was higher than that of the control group (75.00%), the difference was statistically significant (P＜0.05).After treatment, serum creatinine, serumuricacid, random urinary albumin, cystatin C concentration in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The scores of the quality of life (SF-12) scale after treatment in the observation group were higher than those in the control group, the differences were statistically significant (P ＜0.05).The total incidence of adverse reactions between the two groups was not statistically significant (P＞0.05).Conclusions Niaoduqing Granules combined with Febuxostat has significant clinical efficacy and good safety.It can effectively control various indicators that change due to the disease and Improve quality of life.
2020 Vol. 27 (23): 29-31转35 [Abstract] ( 57 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
32 Application effect of medical association telemedicine in the rapid treatment of regional cerebrovascular disease
XU Yong-zhong；HU Zhao-hui；CAI Min； WANG Xue-jun；YAO Wei-ping；LIANG Song
Objective To explore the affect of medical association telemedicine in the rapid treatment of regional cerebrovascular diseases, to study and improve the hierarchical diagnosis system and mechanism of cerebrovascular diseases.Methods A total of 100 patients with acute stroke admitted to our hospital from January 2018 to December 2019 were selected as the research objects.According to random number table method, they were divided into the telemedicine group (50 cases) and the traditional treatment group (50 cases).Telemedicine technology was applied for the telemedicine group to diagnose and transport cerebrovascular diseases, and previous traditional treatment methods in the medical association was used for the traditional treatment group.The time of diagnosis, time of transfer, door-toneedle time (DNT), door-to-puncture time (DPT), average time for hospital stay, modify rankin scale (mRS) at the time of discharge and 3 months after discharge were compared between the two groups.Results The time of diagnosis, time of transfer, DNT, DPT and average hospitalization time in the telemedicine group were less than those in the traditional treatment group, the differences were statistically significant (P＜0.05).The mRS score of the telemedicine group at discharge and 3 months after discharge were lower than those of the traditional treatment group, the differences were statistically significant (P＜0.05).Conclusion The setup of medical association telemedicine can promote the establishment of a continuous, rapid and standardized mode of diagnosis and treatment of stroke disease, improve the overall level of diagnosis and treatment of cerebrovascular diseases, ensure the homogeneity of diagnosis and treatment of cerebrovascular diseases, and reduce the disability rate of acute stroke disease.
2020 Vol. 27 (23): 32-35 [Abstract] ( 40 ) HTML (37 KB)  PDF  (0 KB)  ( 8 )
36 Clinical effect of vascularized iliac bone flap transplantation in the treatment of early necrosis of femoral head
LIU Dong-ping；YAO Lei；WANG Cheng；LIU Shu-zhang；KANG Zhao-he
Objective To explore the clinical effect of vascularized iliac bone flap transplantation in the treatment of early femoral head necrosis, analyze the causes of lateral femoral cutaneous nerve injury, and propose effective prevention and treatment methods.Methods From January 2016 to January 2019, 60 patients of early necrosis of femoral head in our hospital were retrospectively selected.According to the treatment methods, they were divided into a study group undergoing vascularized iliac bone graft transplantation and a control group receiving simple iliac bone graft transplantation.The visual analogue scale (VAS) score, Harris score, the excellent rate of hip joint function in one year after surgery, and the lateral femoral cutaneous nerve injury of the two groups before and after surgery were statistically analyzed.Results There were no significant differences in VAS score and Harris score between the two groups before surgery (P＞0.05);the VAS score of patients in the two groups at the 6th and 12th month after surgery was gradually reduced (P＜0.05), and the Harris score was gradually increased (P＜0.05).The VAS score of the study group at the 6th and 12th month after surgery was lower than that of the control group, and the Harris score was higher than that of the control group, the differences were statistically significant (P＜0.05).There was no significant difference in hip joint function between the two groups before surgery (P＞0.05);the hip joint function of the two groups of patients at the 6th and 12th month after surgery was better than that before surgery (P＜0.05);the hip joint function of the patients in the 6th and 12th month after surgery in the study group was better than that in the control group (P＜0.05).The function of the lateral femoral cutaneous nerve in the first year in the study group was better than that in the first, third, and the sixth month, the differences were statistically significant (P＜0.05).Conclusion Vascularized iliac bone flap transplantation has good clinical effect in the treatment of early femoral head necrosis, but it is necessary to be alert to iatrogenic lateral femoral cutaneous nerve injury, and it should be diagnosed and treated in time.
2020 Vol. 27 (23): 36-39 [Abstract] ( 44 ) HTML (40 KB)  PDF  (0 KB)  ( 6 )
40 Application effects of questionnaire assessment-based health education in early rehabilitation of young and middle-aged patients with stroke
XU Xiao-shuang；HUANG Ying-hua；WU Yuan-rong；LI Meng
Objective To explore the application effects of questionnaire assessment-based health education in early rehabilitation of young and middle-aged patients with stroke.Methods A total of 60 young and middle-aged patients with stroke admitted to our hospital from September 2017 to March 2019 were selected as research subjects, and they were divided into the study group (30 cases) and the control group (30 cases) according to the random number table method.The control group was given routine health education, and the study group was given questionnaire assessment-based health education.Before intervention and after 4 weeks of intervention, the compliance, limb function and quality of life were compared between the two groups.Results There was no statistically significant difference in the exercise adherence questionnaire (EAQ) score between the two groups before intervention (P＞0.05).The score of EAQ in study group after intervention was higher than that in control group, the difference was statistically significant (P＜0.05).There was no statistically significant difference in the SCL-90 score between the two groups before intervention(P＞0.05).The SCL-90 scores in the two groups after intervention were lower than those before intervention, the differences were statistically significant (P＜0.05).The SCL-90 score in the study group after intervention was lower than that in control group, the difference was statistically significant (P＜0.05).There were no statistically significant differences in the scores of Modified Barthel Index (MBI) and Fugl-Meyer Assessment (FMA) and the scores of items of stroke specific quality of life (SS-QOL) between the two groups before intervention (P＞0.05).The scores of MBI and FMA and scores of items of SS-QOL in the two groups after intervention were higher than those before intervention, the differences were statistically significant (P＜0.05).The scores of MBI and FMA and scores of items of SS-QOL in the study group after intervention were higher than those in the control group, the differences were statistically significant(P＜0.05).Conclusion Questionnaire assessment-based health education can effectively improve the compliance of early rehabilitation exercise and enhance the limb function, psychological status and quality of life of young and middle-aged patients with stroke.
2020 Vol. 27 (23): 40-43 [Abstract] ( 44 ) HTML (36 KB)  PDF  (0 KB)  ( 6 )
44 Effect of Amiodarone Hydrochloride combined with Wenxin Granules in the treatment of acute exacerbation of chronic obstructive pulmonary disease with arrhythmia
DING Yue-mei；LIU Juan-feng
Objective To investigate the effect of Amiodarone Hydrochloride combined with Wenxin Granules in the treatment of acute exacerbation of chronic obstructive pulmonary disease with arrhythmia.Methods From September 2016 to September 2019, 100 patients with acute exacerbation of chronic obstructive pulmonary disease with arrhythmia were selected for study.According to the random number table method, they were divided into the control group and the observation group, 50 cases in each group.The patients in the two groups received routine symptomatic treatment, the control group was given Amiodarone Hydrochloride treatment, and the observation group was added with Wenxin Granules on this basis.All patients were treated for 2 weeks.The treatment effect after the end of treatment,the results of dynamic electrocardiogram before and after treatment and the incidence of adverse reactions during the treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).After treatment, the frequency of premature ventricular contractions in the observation group was lower than that in the control group, and the ST segment depression and duration of ST segment depression in the observation group were shorter than those of the control group,the differences were statistically significant (P＜0.05).There was no significant difference in the total incidence of adverse reactions during the treatment between the two groups (P＞0.05).Conclusion Wenxin Granules can improve the therapeutic effect of arrhythmia in acute exacerbation stage of chronic obstructive pulmonary disease, improve the frequency of ventricular premature beat, the duration of ST segment depression and ST segment depression, and do not increase the adverse reactions of patients, which is worthy of clinical recommendation.
2020 Vol. 27 (23): 44-46 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 5 )
47 Effect of different doses of Tigecycline combined with aminoglycoside antibacterials in the treatment of patients with severe pneumonia caused by ICU-resistant Acinetobacter baumannii
SU Hang；GANG Li
Objective To investigate the effect of different doses of Tigecycline combined with aminoglycosides in the treatment of patients with severe pneumonia caused by ICU-resistant Acinetobacter baumannii.Methods A total of 90 patients with severe pneumonia caused by ICU-resistant Acinetobacter baumannii treated in our hospital from July 2016 to July 2019 were selected as the research object, according to random number table method, they were divided into the control group and the study group, 45 cases in each group.The control group was treated with conventional doses of Tigecycline combined with aminoglycoside antibacterials, and the study group was treated with high doses of Tigecycline combined with aminoglycoside antibacterials.The bacterial clearance rate, SOFA score, APACHE Ⅱscore,the incidence rate of adverse reaction and mortality between the two groups were compared.Results The bacterial clearance rate of patients in the study group was higher than that in the control group, and the differences was statistically significant (P＜0.05).The SOFA score, APACHE Ⅱscore and mortality rate of the study group were lower than those of the control group, and the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05).Conclusion High dose Tigecycline combined with aminoglycosides in the treatment of patients with severe pneumonia caused by ICU-resistant Acinetobacter baumannii has good effect, which can significantly improve the body′s bacterial clearance rate, and reduce the mortality of patients, it has high drug safety, which is worthy of clinical promotion.
2020 Vol. 27 (23): 47-49 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
50 Application of uric acid lowering drugs in interventional patients with coronary heart disease and hyperuricemia
HUANG Qian-e；CAI Qin-hong；HUANG Yu-qing；ZHU Hong-guo
Objective To investigate the preventive effect of uric acid lowering drugs on coronary artery disease complicated with contrast-induced nephropathy (CIN), and the effect on hypersensitive C reactive protein (hs-CRP) levels.Methods A total of 90 patients who were hospitalized in the Department of Cardiology of the Zengcheng District People′s Hospital of Guangzhou from January 2017 to January 2019 and were diagnosed with coronary heart disease and hyperuricemia were admitted to the hospital for coronary angiography or stent implantation patient.Random number table method was used to divide patients into control group, febuxostat group and benzbromarone group, 30 cases in each group.Patients were treated with secondary prevention of coronary heart disease before angiography or stent implantation.The patients in the febuxostat group was treated with Febuxostat 40 mg/d 24 hours before surgery, and the patients in the benzbromarone group was treated with Benzbromarone 50 mg/d 24 hours before surgery.The patients in the control group did not receive any uric acid lowering drugs.The levels of blood creatinine, blood uric acid, cystatin C (Cys-C), and hs-CRP were compared among the three groups at 48 hours before surgery and 72 hours after surgery,and the incidence of CIN was recorded.Results There were no significant differences in serum creatinine and Cys-C levels among the three groups after 72 hours (P＞0.05).The blood uric acid and hs-CRP of the febuxostat group and benzbromarone group at 72 hours after surgery were lower than those of the control group (P＜0.05).The blood uric acid level in the febuxostat group and the benzbromarone group at 72 hours after surgery was lower than that at 48 hours before surgery, the difference was statistically significant (P＜0.05).The levels of serum creatinine, Cys-C and hs-CRP at 72 hours after surgery in febuxostat group and benzbromarone group were compared with 48 hours before surgery, the differences were not statistically significant (P＞0.05).The incidence of CIN in the febuxostat group was 13.33% (4/30),the incidence of CIN in the benzbromarone group was 13.33% (4/30), and the incidence of CIN in the control group was 16.67% (5/30).There was no significant difference in the incidence of CIN among groups (P＞0.05).Conclusion Starting uric acid lowering therapy 24 hours before surgery cannot reduce the incidence of CIN in patients with coronary heart disease and hyperuricemia, but it can reduce the level of hs-CRP.The effect on long-term renal function after surgery needs further study.
2020 Vol. 27 (23): 50-53 [Abstract] ( 39 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
54 Clinical application effect of interventional therapy on patients with lower extremity arteriosclerosis obliterans
ZHANG Hua-wei；WANG Zhi-sheng；LUO Xue-fen
Objective To explore the clinical application effect of interventional therapy on patients with lower extremity arteriosclerosis obliterans.Methods A total of 126 patients with lower extremity arteriosclerosis obliterans treated in our hospital from December 2015 to December 2018 were selected as research subjects.They were divided into control group (n=63) and observation group (n=63) by random number table method.Patients in the control group were treated with conventional drug therapy, and patients in the observation group were treated with interventional therapy.The hemodynamic indicators (erythrocyte sedimentation rate, fibrinogen, plasma viscosity and whole blood viscosity), ultrasound findings (middle layer thickness of carotid intima, ankle brachial index and conduction velocity of pulse wave),improvement time of disease (relief time of limb cold, rest pain and intermittent claudication and hospitalization time),clinical effect, sequelae (epilepsy, cerebral palsy and neurodevelopmental retardation) of the two groups were compared.Results After treatment, the erythrocyte sedimentation rate, fibrinogen, plasma viscosity, whole blood viscosity, middle layer thickness of carotid intima and conduction velocity of pulse wave in the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05).The ankle brachial index of the two groups after treatment was higher than that before treatment, and the difference was statistically significant (P＜0.05).After treatment, the erythrocyte sedimentation rate, fibrinogen, plasma viscosity, whole blood viscosity, middle layer thickness of carotid intima and conduction velocity of pulse wave in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).The ankle brachial index of the observation group after treatment was higher than that of the control group, the difference was statistically significant (P＜0.05).The relief time of limb cold,rest pain and intermittent claudication and hospitalization time in the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05).The total effective rate of treatment in the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).The total incidence of sequelae in the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion Interventional treatment has a remarkable therapeutic effect on lower extremity arteriosclerosis obliterans.It can improve the hemodynamic status and shorten the time of treatment.
2020 Vol. 27 (23): 54-57 [Abstract] ( 32 ) HTML (40 KB)  PDF  (0 KB)  ( 6 )
58 Application of expectoration machine in expectoration of patients with acquired weakness in ICU
LU Jun-jiang；LIAO Jian-kun；LIANG Guo-xing；FAN Xiong-hui；LIU Jun-ling
Objective To explore the application of expectoration machine in expectoration of patients with acquired weakness in ICU.Methods From February to November 2018, 90 patients diagnosed with acquired debilitating disease in the ICU of our hospital were selected as the research objects.They were divided into a control group and an observation group by random number table method, with 45 cases in each group.Both groups were treated with conventional treatment and nursing, and the observation group added sputum machine treatment based on conventional treatment and nursing.The mechanical ventilation time, ICU hospital stay, and Medical Research Council (MR C) scores of the two groups were compared and analyzed.Results There was no significant difference in sputum excretion between th e two groups of patients 1 d before enrollment (P＞0.05).The sputum output of the observation group on the days 1 to 3 of treatment was higher than th at of the control group, the sputum output on days 4 to 5 of treatment was lower than that in the control group, and the differences were sta tistically significant (P＜0.05).The pressure support/pressure control and airway resistance of the observation group after 48 hours of treatment were lower than those of the control group,and the lung compliance and cough peak flow rate we re higher than those of the control group, the differences were statistically significant (P＜0.05).The mechanical ventilation time and I CU hospitalization time in the observation group were shorter than those of the control group, the differences were statistically significant (P＜0.05);but the MRC grade comparison between the two groups of patients, the difference was not statistically significant (P＞0.05).Conclusion The applicat ion of expectoration machine in ICU-acquired weakness patients with mechanical ventilation can improve the expectoration effect, improve the respira tory function, shorten the time of mechanical ventilation and ICU hospitalization, and improve the clinical treatment effect.
2020 Vol. 27 (23): 58-60转64 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 5 )
61 Clinical effect of cold snare resection of small colorectal polyps
CUI Yue；LI Sheng-xi
Objective To explore the clinical effect of cold snare resection of small colorectal polyps.Methods The clinical data of 240 patients with colorectal polypectomy (diameter 4-9 mm) in our hospital from June 2018 to June 2019 were analyzed retrospectively, divided into cold snare group (n=120) and hot snare group (n=120) according to different treatment methods.The operation time, specimen recovery rate, total complication rate, polyp location and pathological type of the two groups were compared.Results The operation time of cold snare group was (117.70±9.20)s, and that of hot snare group was (132.50 ±15.92) s, the operation time of cold snare group was shorter than that of hot snare group, the difference was statistically significant (P＜0.05).The specimen recovery rate of cold snare group was 93.5%, and that of hot snare group was 96.7%, there was no significant difference between the two groups (P＞0.05).The complication rate of cold snare group was 1.67%, and that of hot snare group was 3.33%, there was no significant difference between the two groups (P＞0.05).There was no significant difference in polyp location and pathological type between two groups (P＞0.05).Conclusion The operation time of cold snares to remove small colorectal polyps (diameter 4-9 mm) is shorter than that of hot snares to remove small colorectal polyps, which is worthy of clinical application.
2020 Vol. 27 (23): 61-64 [Abstract] ( 32 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
65 Analysis of related factors of early hypokalemia in acute myocardial infarction and clinical effect of targeted potassium supplementation
ZHAO Shi-cai
Objective To explore the related factors of early hypokalemia in acute myocardial infarction and the effect of targeted potassium supplementation therapy.Methods A retrospective analysis of 150 AMI patients admitted to our hospital was divided into hypokalemia group (n=36) and normal potassium group (n=114) according to blood potassium level.Univariate and multi-factor unconditional Logistic regression analysis were used to analysis the related risk factors affecting hypokalemia.The hypokalemia group was given normal or intensive potassium supplementation treatment,and hypokalemia patients were divided into groups A and B, 18 cases in each group.Among them, group A was given oral potassium supplement therapy, group B was combined with central intravenous potassium supplement therapy, and the changes of blood potassium concentration before treatment and after 2 to 12 h of treatment in both groups were observed.Results The single factor analysis showed that there were significant differences between the early onset of AMI and the occurrence of arrhythmia in the hypokalemia group and the normal potassium group (P＜0.05).Multi-factor unconditional Logistic regression model analysis results showed that the early onset time of AMI≤6 h (β=2.012, OR=7.480, 95%CI=1.001-9.040), atrioventricular block (β=2.032, OR=7.630, 95%CI=1.002-9.110), ventricular fibrillation and ventricular tachycardia (β=2.050, OR=7.770, 95%CI=1.006-10.153) were all independent risk factors for hypokalemia (P＜0.05).The blood potassium concentration in groups A and B after treatment at 4, 8, and 12 h were all higher than those before treatment, and the differences were statistically significant (P＜0.05);and after treatment at 4,8, and 12 h, the blood potassium concentrations in group B were higher than those in group A, the differences were statistically significant (P＜0.05).Conclusion Early onset time of AMI≤6 h, atrioventricular block, ventricular fibrillation,and ventricular tachycardia are all risk factors for hypokalemia, and targeted potassium supplementation treatment can significantly improve the early hypokalemia patients Blood potassium concentration.
2020 Vol. 27 (23): 65-67转71 [Abstract] ( 39 ) HTML (34 KB)  PDF  (0 KB)  ( 4 )
68 Analysis of influencing factors on coronary artery disease
WANG Hui；XU Xin-yu▲
Objective To investigate the influence factors of coronary artery disease (CAD).Methods A total of 1068 consecutive patients were enrolled in the Shihezi Municipal People Hospital from August 2017 and December 2019.According to the angiography results, they were divided into CAD group (651 cases) and non-CAD group (417 cases).The biochemical characteristics and ABO blood types were analyzed, multipal factors were analyzed by Logistic regression analysis.Results Univariate analysis showed that compared with the non-CAD group, the male, age, smoking, hypertension, diabetes, and body mass index levels of the CAD group were higher than those of the non-CAD group, the HDL cholesterol level was lower than that of the non-CAD group, the differences were statistically significant (P＜0.05);the differences in the prevalence of coronary heart disease between different blood types were statistically significant(P＜0.05), of which the prevalence of coronary heart disease in blood type A was higher than other blood types, the difference was statistically significant(P＜0.05);the total cholesterol, triacylglycerol and low-density lipoprotein cholesterol between the two groups were not statistically significant (P ＞0.05).Multivariate binary Logistic regression analysis showed that, blood type A (β=0.20, OR=1.22, 95%CI=1.08-1.36), male (β=0.70, OR=2.02, 95%CI=1.31-2.73), age(β=0.39, OR=1.48, 95%CI=1.14-1.82), smoking (β=0.75, OR=2.11, 95%CI=1.68-2.54), diabetes (β=1.30,OR=3.66,95%CI= 2.38-4.94), body mass index (β=0.03, OR=1.03, 95%CI=1.01-1.05) were the risk factors for coronary heart disease(P＜0.05), high-density lipoprotein cholesterol (β=-0.31, OR=0.73, 95%CI=0.54-0.92) was a protective factor for coronary heart disease(P＜0.05).Conclusions The present study indicates that the blood type A,male, age, smoking, diabetes,body mass index may be risk factors for CAD, HDL-C may be a protective factor for CAD.
2020 Vol. 27 (23): 68-71 [Abstract] ( 34 ) HTML (36 KB)  PDF  (0 KB)  ( 6 )
72 Clinical effect of subtotal thyroidectomy in the treatment of patients with bilateral nodular goiter
LI Zhuo-cheng；HUANG Chao-you；HAN Zheng
Objective To explore the clinical effect of subtotal thyroidectomy in patients with bilateral nodular goiter.Methods A total of 124 cases treated by bilateral nodular goiter patients were selected from breast and thyroid specialties department of He Xian Memorial Hospital of Panyu District in Guangzhou City from March 2016 to May 2018, they were divided into control group and research group, with 62 cases in each group according to the lottery method.The control group underwent total thyroidectomy, and the study group underwent subtotal thyroidectomy.The hospital stay and operation time, complications, recurrence rate, and total effective rate were compared between the two groups.Results The hospitalization time and operation time of the study group were shorter than those of the control group, and the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of recurrent laryngeal nerve injury, parathyroid injury, and hypothyroidism between the two groups (P＞0.05).The recurrence probability of the study group (0.00%) was lower than that of the control group (6.45%), and the difference was statistically significant (P＜0.05).The treatment efficiency of the study group (96.77%) was higher than that of the control group(87.09%), the difference was statistically significant (P＜0.05).Conclusion Subtotal thyroidectomy can reduce the recurrence rate of patients with bilateral nodular goiter, improve the curative effect, and the effect is more ideal.
2020 Vol. 27 (23): 72-74 [Abstract] ( 36 ) HTML (32 KB)  PDF  (0 KB)  ( 4 )
75 Application of dual-track interactive nursing intervention method in the patients with diabetes
WANG Li-shuang；ZOU Ting-ting
Objective To explore application of dual-track interactive nursing intervention method in the patients with diabetes.Methods From September 2018 to September 2019, 158 diabetic patients who were managed in the first department of endocrinology in our hospital were selected.They were divided into two groups according to the random number table method, with 79 cases in each group.The control group was given routine nursing measures, and the observation group was given dual-track interactive nursing intervention method on the basis of the control group.The blood glucose levels, total mastering rate of diabetes knowledge and total treatment compliance were compared between the two groups before and after nursing.Results After nursing, the fasting blood glucose, blood glucose at 2 hours after meal and glycated hemoglobin were lower than before nursing, the differences were statistically significant (P＜0.05);fasting blood glucose, blood glucose at 2 h after meal and glycated hemoglobin in observation group after nursing were lower than those in control group, the differences were statistically significant (P＜0.05).After nursing, the observation group′s total knowledge rate of diabetes and total treatment compliance were higher than those of the control group, the differences were statistically significant (P＜0.05).Conclusion The dual-track interactive nursing intervention model for diabetic patients has a significant effect, which can effectively reduce blood glucose, improve the overall mastering rate of diabetes knowledge and treatment compliance.
2020 Vol. 27 (23): 75-77 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 5 )
78 Clinical effect of intensive treatment of Metformin combined with Insulin Aspart 30 Injection in the treatment of newly developed type 2 diabetes
WEI Zhen-hong
Objective To investigate the clinical effect of Metformin combined with Insulin Aspart 30 Injection in the treatment of newly developed type 2 diabetes mellitus.Methods A total of 156 cases of patients with newly developed type 2 diabetes who admitted to our hospital from August 2016 to January 2019 were selected, they were divided into control group (78 cases) and observation group (78 cases) according to the random number table method.Metformin was given to both groups, on this basis, the control group was given Isophane Protamine Biosynthetic Human Insulin Injection treatment, and the observation group was given Insulin Aspart 30 Injection intensive treatment.The clinical efficacy and blood sugar level, time of blood sugar reaching the standard, dynamic blood sugar monitoring index and quality of life score were compared between the two groups.Results The total clinical effective rate (97.44%) of the observation group was higher than that of the contr ol group (87.18%), the difference was statistically significant (P＜0.05).The time of blood glucose reaching the standard in the obse rvation group was shorter than that in the control group, the difference was statistically significant (P＜0.05).After treatment, the leve ls of fasting blood glucose and 2 h postprandial blood glucose in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The time ratio of hyperglycemia, time ratio of hypoglycemia, fluctuation coefficient of blood glucose and in cidence of hypoglycemia in the observation group were lower than those in the control group, the differences were statistically signifi cant (P＜0.05).After treatment, the quality of life score in the observation group was higher than that in the control group, the diff erence was statistically significant (P＜0.05).Conclusion Metformin combined with Insulin Aspart 30 Injection intensive therapy can b etter control the blood sugar level of patients with newly developed type 2 diabetes mellitus, reduce the blood sugar level as soon as possible, reduce the f luctuation of blood sugar, reduce the incidence of hypoglycemia, and improve the quality of life.
2020 Vol. 27 (23): 78-81 [Abstract] ( 41 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
82 Application of one-stage suturing of common bile duct exploration under choledochoscope in extrahepatic bile duct stones
ZHAO Xin-hua
Objective To explore the application of one-stage suture of common bile duct exploration under choledochoscope in extrahepatic bile duct stones.Methods From June 2017 to June 2018, 114 patients with extrahepatic choledocholithiasis in our hospital were selected as the research objects, and they were divided into observation group and control group by random number table method, 57 cases in each group.The patients in the control group were treated with laparoscopic and choledochoscope for common bile duct exploration, stone removal, and treated with Ttube drainage.The patients in the observation group were treated with laparoscopic and choledochoscope for common bile duct exploration, stone removal, and underwent one-stage suture treatment.The general conditions of operation time, intraoperative blood loss, anal exhaust time, postoperative fluid replacement, abdominal drainage tube extubation time and hospitalization time in the two groups of patients were compared.And follow-up statistics of the incidence of complications such as bile leakage, common bile duct stenosis, infection, and recurrence of stones in the two groups of patients.Results The operation time, anal exsufflation time and hospitalization time of the patients in the observation group were shorter than those in the control group, and the amount postoperative fluid replacement was less than that in the control group, the differences were statistically significant (P＜0.05).There were no significant differences in intraoperative blood loss and abdominal drainage tube extubation time between the two groups (P＞0.05).There were no significant differences in the total incidence of complications and stone recurrence rate between the two groups (P＞0.05).Conclusion One-stage suturing of common bile duct exploration under choledochoscope to treat patients with extrahepatic bile duct stones has short surgery time and quick recovery after surgery.It is a safe and effective treatment.
2020 Vol. 27 (23): 82-84 [Abstract] ( 45 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
85 Application of the concept of rapid rehabilitation surgery in patients with laparoscopic cholecystectomy
WANG Li-xia
Objective To explore the application of the concept of rapid rehabilitation surgery in patients with laparoscopic cholecystectomy.Methods A total of 116 patients who laparoscopic cholecystectomy in our hospital from March 2018 to March 2019 were selected as the research objects.They were divided into a control group (58 cases) and an observation group (58 cases) according to the red and blue color ball method.The control group adopted routine nursing, and the observation group adopted rapid rehabilitation surgery.The postoperative recovery and complications of the two groups were compared.Results The total amount of infusion in the observation group was (9.09±3.17) L, which was less than that in the control group of (13.24±4.15) L, the difference was statistically significant (P＜0.05).The postoperative pain score of the observation group was (3.12±0.53) points, which was lower than that of the control group of(5.29±0.47) points, the difference was statistically significant (P＜0.05).The exhaust time of the observation group was(26.27±6.49) h, the time to get out of bed was (1.14±0.38) d, the hospitalization time was (5.79±0.93) d, which were shorter than those in the control group of (40.08±4.28) h, (2.82±0.64) d, (7.82±0.97) d, and the differences were statistically significant (P＜0.05).The total incidence of complications such as bile leakage, lung infection, incision infection,and peritoneal effusion in the observation group (8.62%) was lower than that in the control group (24.14%), the difference was statistically significant (P＜0.05).Conclusion Applying the concept of rapid rehabilitation surgery can help alleviate pain in patients with laparoscopic cholecystectomy, reduce occurrence of complications such as bile leakage,lung infections, incision infections, and peritoneal effusions, shorten the patients′ exhaust time, get out of bed time, and promote their early recovery and smooth discharge from hospital.
2020 Vol. 27 (23): 85-87转91 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 5 )
88 Effect comparison of the Thompson method and wire-pulling out method for reconstruction of the terminal of extensor tendon in the treatment of old mallet finger
LIU Bin；HU Xue-bin；TAO Hong-bo；LIU Yan-qin；HE Cheng-jie；JIN Dong
Objective To evaluate the clinical effect of Thompson method and wire-pulling out method for reconstruction of the terminal of extensor tendon in treating old wallet finger.Methods A total of 40 patients with old mallet finger admitted into the Department of Surgery of the Wuhan Wudong Hospital from June 2012 to June 2016 were collected as research objects, and they were divided into two groups according to different treatment methods.Thompson method was used to treat 20 cases of mallet finger (group A), other 20 cases (group B) were treated with wire-pulling out method to reconstruct the terminal of extensor tendon, and the therapeutic effect of the two surgical methods were compared.Results In group A, 16 cases were followed up for 6 months after surgery, according to the TAM functional assessment system, 8 cases were excellent, 6 good, 2 fair, and 0 poor, the excellent and good rate was 87.5%.In group B, 18 cases were followed up for 6 months after surgery, according to the TAM functional assessment system, 4 cases were excellent, 5 good, 4 fair, 5 poor, the excellent and good rate was 50.0%.In group A, 2 patients had foreign body formation under the skin after surgery, and the total incidence of complications was 12.5%.In group B, 4 patients had skin necrosis of incision or finger pulp after surgery, 4 patients had foreign body formation under the skin, and the total incidence of complications was 44.4%.No one had a relapse of mallet finger in group A, and the recurrence rate was 0.0%;4 patients had a relapse of mallet finger in group B, and the recurrence rate was 22.2%.The excellent and good function rate in group A was higher than that in group B, and the total incidence of complications and recurrence of mallet finger were lower than those in group B, the differences were statistically significant (P＜0.05).Conclusion Adopting Thompson method to treat mallet finger has a low recurrence rate and fewer complications, and can correct swan-neck deformity with satisfactory effect.
2020 Vol. 27 (23): 88-91 [Abstract] ( 34 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
92 Effect of Yiqi Jiedu Recipe combined with chemotherapy in the treatment of patients with advanced triple-negative breast cancer
QIU Zhi-min；WANG Ling；ZHENG Zhi；WANG Mei-jian；SU Yong-feng
Objective To investigate the effect of Yiqi Jiedu Recipe combined with chemotherapy in the treatment of patients with advanced triple-negative breast cancer.Methods Fifty-six patients with advanced triple-negative breast cancer admitted to Jiangxi Provincial Cancer Hospital from June 2018 to June 2019 were selected as the study subjects.They were divided into control group(28 cases)and research group (28 cases) according to random number table method.The control group was treated with routine chemotherapy, while the research group was treated with Yiqi Jiedu Recipe on the basis of control group.The short-term efficacy, T lymphocyte subsets (including CD4+, CD8+, CD4+/CD8+), serum tumor markers (cancer antigen 125 [CA125], carcinoembryonic antigen [CEA], cancer antigen 153 [CA153]), quality of life scores and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the research group was 85.71%, which was higher than that in the control group accounting for 53.57%,the difference was statistically significant (P＜0.05).After treatment, the levels of CD4+, CD4+/CD8+ in the research group were higher than those in the control group, with statistical significances (P＜0.05).The level of CD8+ in the research group was lower than that in the control group,with statistical significance (P ＜0.05).After treatment,the levels of CEA, CA125 and CA153 in the research group were lower than those in the control group, with statistical significances (P＜0.05).After treatment, KPS score of the research group was higher than that of the control group, with statistical significance (P ＜0.05).The incidence of thrombocytopenia, leukopenia, nausea, vomiting and alopecia in the research group was lower than that in the control group, with statistical significance (P＜0.05).Conclusion Yiqi Jiedu Recipe combined with chemotherapy is effective in the treatment of patients with advanced triple-negative breast cancer, which can effectively improve immune function, inhibit tumor markers, strengthen quality of life,and is worthy of clinical promotion.
2020 Vol. 27 (23): 92-95转99 [Abstract] ( 40 ) HTML (45 KB)  PDF  (0 KB)  ( 7 )
96 Clinical effect comparison of laparoscopic and open radical gastrectomy for gastric cancer
LI Qian；CHEN Ze-qun；SU Zhou-sheng；WANG Wei-wei
Objective To explore the clinical effect of laparoscopic and open radical gastrectomy for gastric cancer.Methods From February 2012 to July 2019, 84 patients with gastric cancer in our hospital were selected as the study objects, and divided into group A (42 cases) and group B (42 cases) according to the random number table method.Laparoscopic gastrectomy was performed in group A and open radical gastrectomy was performed in group B.The perioperative indexes, immune function before and after surgery and incidence of complications were compared between the two groups.Results In group A, the amount of blood loss and the times of using analgesic drugs were less than those in group B, the length of incision, the time of getting out of bed and the time of hospitalization were shorter than those in group B, and the time of operation was longer than that in group B, the differences were statistically significant (P＜0.05).There was no significant difference in the number of lymph node dissections between the two groups (P＞0.05).The levels of CD3+, CD4+, CD4+/CD8+ in group A at 3 days after surgery were (46.38±2.19)%, (29.39±3.24)% and(1.16±0.12)%, which were higher than those in group B for (39.40±2.25)%, (22.45±2.41)%, (0.76±0.10), CD8+level was(25.39±2.45)%, which was lower than (29.65±2.86)% in group B, the differences were statistically significant (P＜0.05).The total incidence rate of complications in group A was 4.76%, which was lower than 21.43% in group B, the difference was statistically significant (P＜0.05).Conclusion Laparoscopic gastrectomy has the same therapeutic effect as open surgery, but the former has the advantages of less trauma, less pain, fewer complications, rapid recovery and less impact on immune function, which is worthy of clinical promotion.
2020 Vol. 27 (23): 96-99 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
100 Clinical effect of surgery after neoadjuvant chemotherapy on middle and advanced cervical cancer
HAN Yu-ying；WANG Qing-yi；KANG Min；YUAN Yan-yan；KUANG Ai-hua
Objective To evaluate the clinical value after neoadjuvant chemotherapy (NACT) in patients with middle and advanced cervical cancer.Methods The clinical data of 76 patients with middle and advanced cervical cancer who underwent radical surgery of cervical cancer in our hospital from June 2016 to June 2019 were retrospectively analyzed,and divided them into research group (n=38) and control group (n=38) according to whether they received NACT before surgery.By analyzing the total effective rate after chemotherapy in the research group and the surgery time, intraoperative blood loss, lymph node metastasis rate and vascular invasion rate of the two groups of patients, the clinical value of surgery after NACT for patients with middle and advanced cervical cancer was evaluated.Results All patients in the research group successfully performed surgery after receiving NACT, with a total effective rate of 65.79% (25/38), of which CR was 0.00% (0/38), PR was 65.79% (25/38), and SD was 34.21% (13/38), PD was 0.00% (0/38).There were no significant differences in the surgery time and intraoperative blood loss between the two groups of patients (P＞0.05).The lymph node metastasis and vascular infiltration rate of the research group was lower than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion NACT before radical surgery of cervical cancer has good effect on middle and advanced cervical cancer, it can reduce the size of cancer, and does not increase the difficulty of surgery, which provides another option for the treatment of patients with middle and advanced cervical cancer.
2020 Vol. 27 (23): 100-103 [Abstract] ( 42 ) HTML (39 KB)  PDF  (0 KB)  ( 7 )
104 Study on Lobaplatin of intraperitoneal perfusion during operation combined with intravascular injection in the treatment of colon cancer
ZHANG Wei；YUAN Yu；LIAO Kai
Objective To explore the effect of Lobaplatin of intraperitoneal perfusion during operation combined with intravascular injection in the treatment of colon cancer.Methods A total of 75 patients with colon cancer admitted to our hospital from January 2018 to September 2019 were selected as the study objects, they were divided into the treatment group (38 cases) and the control group (37 cases) according to random table of case allocation.The treatment group was given Lobaplatin of 50 mg/m2 intraperitoneal hyperthermia plus intraoperative intravascular injection, while the control group was given Lobaplatin of 50 mg/m2 intraperitoneal hyperthermia plus postoperative chemotherapy.The recovery time of gastrointestinal function, the incidence of complications and adverse reactions were compared between the two groups, and the changes of blood cell count and blood biochemical indexes before and after treatment in the two groups were recorded, and the recurrence condition of tumors in the two groups after treatment for 5 months was counted.Results There was no significant difference in the recovery time of gastrointestinal function between the two groups (P＞0.05).The white blood cell count, hemoglobin and platelet count in the two groups after treatment were lower than those before treatment, the differences were statistically significant (P ＜0.05).The white blood cell count,hemoglobin and platelet count in the treatment groups after treatment were higher than those in the control group, the differences were statistically significant (P＜0.05).The levels of alanine aminotransferase, aspartate aminotransferase and creatinine in the two groups after treatment were higher than those before treatment, the differences were statistically significant (P＜0.05).The levels of alanine aminotransferase, aspartate aminotransferase and creatinine in the treatment groups after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05).The incidence rates of nausea and vomiting,peripheral neuropathy, diarrhea, leukopenia, thrombocytopenia, anemia, liver and kidney function damage in the treatment group were lower than those in the control group, the differences were statistically significant (P＜0.05).The recurrence rate in the treatment group was 5.26%, which was lower than 24.32% in the control group, the difference was statistically significant (P＜0.05).Conclusion The effect of Lobaplatin of intraperitoneal perfusion during operation combined with intravascular injection in the treatment of colon cancer is significant, which can significantly reduce the incidence of complications and adverse reactions, and the changes of blood cell count, blood biochemical indicators are smaller, the recurrence rate is lower, which is worthy of clinical promotion and application.
2020 Vol. 27 (23): 104-107 [Abstract] ( 42 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
108 Application effect of delivery plan based on authorization theory in primiparae
ZHENG Fang-mei；’KUANG Xiao-hong；LIU Yan-lan
Objective To explore the application effect of delivery plan based on authorization theory in primiparae.Methods A total of 60 primiparas admitted to Ganzhou Xunwu Maternal and Child Health and Family Planning Service Center from March 2019 to January 2020 were selected as the research objects.According to the random number table method, they were divided into the control group and the observation group, 30 cases in each group.The control group carried out routine nursing.The observation group adopted the individualized nursing mode based on the authorization theory, the delivery outcome, primiparae′s satisfaction and quality of life of the two groups were compared.Results The incidence of perineum laceration, episiotomy, cesarean section, neonatal asphyxia and fetal distress in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The total satisfaction of the observation group was higher than that of the control group,the difference was statistically significant(P＜0.05).The scores of cognitive function, emotional function, role function and body function in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).Conclusion According to the theory of authorization, it is helpful to make delivery plan for primipara, to reduce the occurrence of asphyxia and fetal distress, to improve the outcome of delivery, to improve satisfaction, and to have high clinical application value.
2020 Vol. 27 (23): 108-110 [Abstract] ( 37 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
111 Application effect of comprehensive nursing mode in patients with uterine fibroid surgery
GONG Fang
Objective To explore the effect of comprehensive nursing mode in patients with uterine fibroid surgery.Methods A total of 60 patients underwent uterine fibroid surgery who were treated in our hospital from June 2018 to June 2019 were selected as the research objects.They were divided into control group (30 cases) and observation group(30 cases) according to the random number table method.The control group carried out traditional nursing interventions, while the observation group implemented comprehensive nursing interventions.The anus exhaust time, time to get out of bed, length of hospital stay, and complications were compared between the two groups.The visual analogue score(VAS) was used to assess the surgical tolerance of the two groups.The quality of life measurement scale (EORTC QLQC30) was used to assess the quality of life.Results The anal exhaust time, time to get out of bed, and hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05).The total incidence of postoperative complications in the observation group (6.67%) was lower than that in the control group (16.67%), and the difference was statistically significant (P＜0.05).The social, physical emotional, role and cognitive scores of EORTC QLQ-C30 in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05).The VAS score of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion For patients with uterine fibroid surgery, comprehensive nursing intervention can not only shorten the recovery time and improve the quality of life, but also reduce pain, reduce complications, and have high clinical application value.
2020 Vol. 27 (23): 111-113 [Abstract] ( 37 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
114 Effect of aerobic exercise during pregnancy on delivery outcome
HU Yan-fei
Objective To explore the effect of aerobic exercise during pregnancy on the outcome of labor.Methods From November 2018 to November 2019, 98 pregnant women who underwent pregnancy examination and did delivery in our hospital were selected.They were divided into two groups according to the randomized controlled principle, with 49 cases in each group.The pregnant women in the control group received routine guidance during pregnancy, and the pregnant women in the observation group received guidance on aerobic exercise during pregnancy.The weight gain during pregnancy, emotional state before childbirth, delivery mode, labor pain grading, the time of delivery of pregnant women in natural delivery, and postpartum hemorrhage were compared between the two groups.Results In the observation group, the weight gain during pregnancy, self-rating anxiety scale score and self-rating depression scale score before delivery were lower than those in the control group, and the differences were statistically significant (P＜0.05).The delivery pain grading in the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05).The natural delivery rate of the observation group was higher than that of the control group.The incidence of postpartum hemorrhage was lower than the control group, and the difference was statistically significant (P＜0.05).The time of the first, second, and third stages of labor in pregnant women who gave birth naturally in the observation group were shorter than those of the control group, with statistical significance (P＜0.05).Conclusion Aerobic exercise during pregnancy can control maternal weight gain during pregnancy, improve the emotional state before delivery, and enhance the delivery effect, which is worthy of clinical promotion.
2020 Vol. 27 (23): 114-116 [Abstract] ( 30 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
117 Effect comparison of J-hook anchorage and implant anchorage in the treatment of angle class Ⅰbimaxillary protrusion deformity
ZHAO Xu-chun；LI Qin；WANG Ming-lang；PENG Yi；LI Yuan-yuan
Objective To Comparison of the effect of J-hook anchorage and implant anchorage in the treatment of angle class Ⅰbimaxillary protrusion deformity.Methods A total of 80 patients with class Ⅰbimaxillary protrusion deformity who admitted in our hospital from January to October 2017 were divided into group A (J hook anchor group) and group B (implant anchorage group) by random data table method, 40 cases in each group.The treatment cycle and tooth-related indexes were compared between two groups.Results The mean treatment cycle of group B was shorter than that of group A, with statistically significant difference (P＜0.05).After the rectification, the distance of center of resistance of maxillary molar to palatal plane (U6C-PP) and the level of nasal labial angle (Cm-Sn-UL) in group B were higher than those of group A, and the distance of upper lip to RL (UL-RL) in group B was lower than that in group A, with statistically significant differences (P＜0.05).Conclusion Compared with J-hook anchorage, implant anchorage in the treatment of angle class Ⅰbimaxillary protrusion deformity has shorter cycle and better correction effect.
2020 Vol. 27 (23): 117-119 [Abstract] ( 31 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
120 Effect comparison of continuous penetration suture method and nasal cavity packing in nasal septoplasty
XIE Yong-hong
Objective To compare the effect of continuous penetration suture method and nasal cavity packing in nasal septoplasty.Methods A total of 60 patients who underwent nasal septoplasty from January 2017 to December 2019 in our hospital were selected as the research objects, and they were divided into observation group (n=30) and control group (n=30) according to the random number table method.Patients in the control group were given high-expansion sponges for nasal tamponade postoperatively.Patients in the observation group were treated with continuous penetrating sutures after surgery.The Lund-Mackay scoring system was used to evaluate the nasal endoscopy and sinus CT.The visual analog scale (VAS) was used to evaluate the patients.The clinical symptom improvement degree was followed up two weeks later to compare postoperative complications between the two groups.Results The scores of endoscopic and sinus CT in the observation group were higher than those of the control group, and the scores of VAS were lower than those in the control group (P＜0.05).The postoperative complications in the observation group were lower than those of the control group (P＜0.05).Conclusion After nasal septal plasty, compared with nasal tamponade, the continuous penetration suture method can significantly improve the patients′ postoperative discomfort symptoms, protect the nasal mucosal clearance function, and reduce postoperative complications.
2020 Vol. 27 (23): 120-122 [Abstract] ( 31 ) HTML (32 KB)  PDF  (0 KB)  ( 7 )
123 Application effect of different degrees of root canal filling treatment in dental pulp disease
FU Wei-zhuo
Objective To explore the effect of different degrees of root canal filling treatment in dental pulp disease Methods The clinical data of 99 patients with endodontic disease who were admitted to our hospital from July 2018 to August 2019 were retrospectively analyzed.According to the difference of filling degree, the patients were divided into exact filling group (n=33), underfilling group (n=33) and overfilling group (n=33).After ten days of treatment, the therapeutic effect, score of pain degree, and quality of life score of the exact filling group, underfilling group, and overfilling group were compared.Results The total effective rate of treatment in the exact filling group was 96.97%, which was significantly higher than the total effective rate of 63.64% in the underfilling group and 66.67% in the overfilling group, and the differences among the three groups were statistically significant (P＜0.05).There was no statistically significant difference in the total effective rate between the underfilling group and the overfilling group (P＞0.05).After treatment, the visual analogue scale (VAS) score of pain degree in the exact filling group was (2.29±1.00) points, which was lower than that in the underfilling group of (4.60±1.50) points and the overfilling group of (4.51±1.49) points, the differences among the three groups were statistically significant (P＜0.05).There was no statistically significant difference in VAS score between the underfilling group and overfilling group (P＞0.05).After treatment, the quality of life score in the exact filling group was (89.59±6.82) points, which was higher than that in the underfilling group of (74.71±7.27) points and that in the overfilling group of (75.69±7.62) points, the differences among the three groups were statistically significant (P＜0.05).There was no statistically significant difference in the quality of life score between the underfilling group and overfilling group (P＞0.05).Conclusion Appropriate root canal filling treatment for patients with dental pulp disease can improve the treatment effect of patients, relieve pain and improve quality of life, and have clinical application value.
2020 Vol. 27 (23): 123-125 [Abstract] ( 33 ) HTML (33 KB)  PDF  (0 KB)  ( 7 )
126 Effect of micro-implants combined with metal self-ligating brackets in the treatment of severe crowding anterior teeth
ZHANG Qi-le
Objective To explore the effect of micro-implants combined with metal self-ligating brackets in the treatment of severe crowding of anterior teeth.Methods A total of 103 patients with severely crowded anterior teeth who were admitted to the Affiliated Shunde Hospital of Guangzhou Medical University from January 2014 to December 2017 were selected as the research object, and they were divided into observation group (n=52) and control group (n=51) according to the random number table method.The patients of observation group were treated with the micro-implants and metal self-ligating brackets.The patients of control group were treated with the micro-implants and straight-wire brackets.The speed of alignment movements, the closing time of tooth extraction space, the treatment course, the success rate of orthodontic treatment and the retention rate of micro-implants were compared between the two groups.Results The speed of alignment movements in the observation group was faster than that of control group, the difference was statistically significant (P＜0.05).The closing time of extraction space and the treatment course in the observation group were shorter than those in the control group,the differences were statistically significant(P＜0.05).The success rate of orthodontic treatment and the retention rate of micro-implants in the observation group were higher than those of control group,the differences were statistically significant (P＜0.05).Conclusion The combined application of micro-implants and metal self-ligating brackets is effective in correcting severe crowding of anterior teeth, which can effectively shorten the orthodontic treatment course, improve the success rate of orthodontic treatment, and is worth promoting and applying.
2020 Vol. 27 (23): 126-128转132 [Abstract] ( 35 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
129 Clinical effect of Batroxobin Injection in the treatment of total deafness type sudden deafness
FENG Wei
Objective To explore the clinical effect of Batroxobin Injection in the treatment of total deafness type sudden deafness.Methods A total of 80 patients with total deafness type sudden deafness who were hospitalized from January 2015 to October 2019 were selected as subjects and divided into the observation group and the control group according to the random number table method, with 40 cases in each group.Patients in the control group were treated by intravenous injection of Sodium Methylprednisolone Succinate and intravenous infusion of Extract of Ginkgo Biloba Injection.Patients in the observation group was treated by Batroxobin Injection on the basis of the control group.Pure tone audiometry was performed before and after treatment to compare the curative effect of the two groups and analyze the changes of hearing.Results The apparent efficiency of the observation group was 55.00%, the total effective rate was 72.50%.In the control group, the apparent efficiency was 30.00% and the total effective rate was 67.50%.The apparent efficiency in the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).Comparison of the total effective rate between the two groups showed no statistically significant difference (P＞0.05).After treatment, the average hearing threshold in the low-frequency and middle-frequency regions of the observation group were lower than those of the control group, with statistically significant differences (P＜0.05).There was no statistically significant difference in the average hearing threshold between the two groups in the high-frequency region (P＞0.05).Conclusion Batroxobin Injection was proved effective in the treatment of total deafness type sudden deafness, which could improve the hearing of patients in further.It has positive effect on the improvement of middle and low frequency hearing, but has no effect on the improvement of high frequency hearing.
2020 Vol. 27 (23): 129-132 [Abstract] ( 49 ) HTML (37 KB)  PDF  (0 KB)  ( 5 )
133 Effect comparison of different doses of Nalbuphine combined with Sufentanil on patient-controlled intravenous analgesia and sedation after cesarean section
LIU Jin
Objective To compare the effect of different doses of Nalbuphine combined with Sufentanil on patient-controlled intravenous analgesia and sedation after cesarean section.Methods A total of 500 full-term parturients who underwent cesarean section in our hospital from January to December 2018 were selected as the study objects.They were divided into groups A, B, C, D and E according to the method of random number table method, with 100 cases in each group.After the operation, the pregnant women were given PCIA pump drugs for analgesia.Group A was given 0.5 mg/kg of Nalbuphine + 0.5 μg/kg of Sufentanil.Group B was given 0.5 mg/kg of Nalbuphine+1 μg/kg of Sufentanil.Group C was given 1 mg/kg of Nalbuphine+1 μg/kg of Sufentanil.Group D was given 1 mg/kg of Nalbuphine+1.5 μg/kg of Sufentanil.Group E was given 1.5 mg/kg of Nalbuphine + 1.5 μg/kg of Sufentanil.Visual analogue pain scale (VAS)score, Ramsay sedation score (RSS) and adverse reactions related to analgesia were compared at different time points after cesarean section including two hours (T1), four hours (T2), eight hours (T3), 12 hours (T4), 24 hours (T5), 36 hours(T6), 48 hours (T7).Results The VAS scores of T2, T3, T4 and T5 in the five groups were higher than those of T1, and the differences were statistically significant (P＜0.05).The VAS scores of group B, C, D and E at different time points were lower than those of group A, the VAS scores of group C, D and E at different time points were lower than those of group B, and the VAS scores of group D and E at different time points were lower than those of group C, with statistically significant differences (P＜0.05).The RSS scores of T2, T3, T4 and T5 in the five groups were lower than those of T1, the differences were statistically significant (P＜0.05).The RSS scores of group B, C, D and E at different time points were higher than those of group A, the RSS scores of group C, D and E at different time points were higher than those of group B, the RSS scores of group D and E at different time points were higher than those of group C, and the differences were statistically significant (P＜0.05).The VAS scores and RSS scores in group E at different time points were compared with those of the group D, and the differences were not statistically significant (P＞0.05).The total incidence of postoperative analgesia-related adverse reactions in group C was lower than that in group A, and the difference was statistically significant (P＜0.05).The total incidence of postoperative analgesia related adverse reactions in group B, D and E was not statistically significant compared with that in group A (P＞0.05).Conclusion After cesarean section PCIA formula with 1 mg/kg of Nalbuphine and 1 μg/kg of Sufentanil can not only produce good analgesic and sedative effect, but also reduce the occurrence of adverse reactions.
2020 Vol. 27 (23): 133-136 [Abstract] ( 36 ) HTML (42 KB)  PDF  (0 KB)  ( 7 )
137 Application of parent-accompanied and situational simulation game in anesthesia resuscitation period of children with general anesthesia
FENG Jian-zhen
Objective To explore the application of parent-accompanied combined with scenario simulation games in children under general anesthesia during anesthesia resuscitation.Methods A total of 40 cases of surgical children admitted to our hospital from June 2018 to December 2019 were selected as the research objects.They were divided into control group (n=20) and research group (n=20) according to the random number table method.Both groups received general anesthesia during the operation.The children in the control group received preoperative routine nursing, and the children in the study group received routine nursing combined with parent-accompanied and situational simulation game nursing intervention.The operation related indexes and anesthesia process monitoring indexes were compared between the two groups.Results There was no significant difference in operation time between the two groups (P＞0.05).The postoperative pain score of the study group was lower than that of the control group, the hospitalization time and anaesthetic resuscitation time of the study group were shorter than those of the control group, and the anesthesia cost of the study group was less than that of the control group, with statistically significant differences (P＜0.05).In the study group, the incidence of adverse reactions of anesthesia resuscitation was lower than that of the control group, and the use rate of sedative drugs during anesthesia resuscitation was lower than that of the control group, with statistically significant differences (P＜0.05).Systolic blood pressure and heart rate in anesthesia induction and recovery period in the study group were lower than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion The application of parent-accompanied combined with scenario simulation games in children under general anesthesia during anesthesia resuscitation can effectively shorten the time needed for anesthesia recovery, reduce pain,reduce the risk of anesthesia and children′s physical and mental injury, shorten the hospital stay, reduce additional medical costs, and increase the comfort of children during anesthesia recovery.
2020 Vol. 27 (23): 137-139转143 [Abstract] ( 37 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
140 Application effect of Oxycodone combined with Dexmedetomidine in CTguided radiofrequency ablation of pulmonary nodules
WEI Guo-hua；WANG Juan
Objective To investigate the application effect of Oxycodone combined with Dexmedetomidine in CT-guided radiofrequency ablation of pulmonary nodules.Methods A total of 60 patients who underwent CT-guided radiofrequency ablation of pulmonary nodules in our hospital from March 2018 to September 2019 were selected as the research subjects, aged≤65 years old, American Society of Anesthesiologists (ASA) grade Ⅰand Ⅱ, size of the nodules was ≤3 cm, and they were divided into the control group (30 cases) and the experimental group (30 cases) according to the random number table method.Patients in the control group were anesthetized with Propofol combined with Remifentanil, Propofol at a dose of 1 mg/kg was slowly injected, and the Remifentanil was continuously infused at a dose of 2 mg/(kg·h) until the end of the operation.Patients in the experimental group were anesthetized with Oxycodone combined with Dexmedetomidine, intravenously injected with Oxycodone 0.2 mg/kg, and intravenous injection of Dexmedetomidine 1 μg/kg (pumped within 10 minutes), followed by the speed of 0.2 μg/(kg·h) maintained until the end of the operation.The heart rate (HR), pulse oxygen saturation (SpO2) and mean arterial pressure (MAP) when entering the room (T0), when the operation started (T1), when the operation started 10 minutes (T2), when the operation ended(T3), after the operation ended 10 minutes (T4) of the two groups of patients were recorded.The recovery time of the two groups of patients was compared and the visual analogue scale (VAS) scores of the two groups of patients at the time of waking up (t0), 10 min after waking up (t1) and 30 min after waking up (t2) were recorded.The incidence of adverse reactions, such as respiratory depression, intraoperative hypotension, body movement and nausea and vomiting, was recorded in both groups.Results The recovery time of the experimental group was shorter than that of the control group, and the difference was statistically significant (P＜0.05).There were no statistically significant differences in HR,MAP and SpO2 at T0, T1, T2, T3 and T4 between the two groups of patients (P＞0.05).The VAS score at t2 and the incidence rate of respiratory depression in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion Oxycodone combined with Dexmedetomidine can be safely and effectively used in CT-guided radiofrequency ablation of pulmonary nodules
2020 Vol. 27 (23): 140-143 [Abstract] ( 37 ) HTML (44 KB)  PDF  (0 KB)  ( 6 )
144 Application of acupuncture combined with traditional Chinese medicine fumigation and bathing in patients with mixed hemorrhoids after surgery
GONG Hua-cheng；GONG Jia-wei；FAN Jian-ping；PENG Ying-ying；HU Xiao-yang；LIU Qin-yuan
Objective To investigate the efficacy of acupuncture combined with traditional Chinese medicine fumigation bath in patients with mixed hemorrhoids after surgery.Methods A total of 84 patients with mixed hemorrhoids who underwent surgery in the Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2017 to June 2019 were selected and divided into group A and group B according to the random number table method,with 42 patients in each group.Group B was treated with Potassium Permanganate Solution for fumigation and bathing,and group A was treated with acupuncture combined with Chinese medicine for fumigation and bathing.The symptoms improvement time, duration of anal swelling, degree of anal swelling, anal pain, inflammation and adverse reactions were compared between the two groups.Results The time of edema, pain, exudate disappearance, wound healing time and anal distension duration in group A were shorter than those in group B, the degree of anal swelling and anal pain score in group A were lower than those in group B, with significant differences (P＜0.05).The levels of interleukin-17(IL-17) and tumor necrosis factor-α (TNF-α) in group A were lower than those in group B, and the differences were statistically significant (P＜0.05).During treatment, there were no adverse reactions in both groups.Conclusion Acupuncture combined with traditional Chinese medicine fumigation and bathing treatment for patients with mixed hemorrhoids can effectively shorten the time to improve clinical symptoms, reduce the degree of anal swelling and pain,reduce the level of inflammatory factors, and help patients recover, which has high security.
2020 Vol. 27 (23): 144-147 [Abstract] ( 42 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
148 Proved cases on professor Yang Lianfang in reducing phlegm and resolving masses method in treating mammary nodules
JIANG Ying；LI Xiu-yun
Mammary nodules as the one of common female diseases in modern society, brings lots of problems to life and work.The effects of western medicine and surgical operation are not satisfactory, thus it′s very important to find a treatment with good effect and little side effect.Professor Yang Lianfang, famous traditional Chinese medicine doctor,has rich experiences in clinical diagnosis and treatments.This paper analyzed two typical cases with the teacher to summarize the treatment experiences of mammary nodules.In view of the phlegm and dampness constitution of women in Sichuan and Chongqing, attaching importance to the basic treatment of reducing phlegm and resolving masses, as well as combining many and various treatments, such as soothing the liver and regulating qi, conditioning chongren disharmony, and warming the kidney-yang, only by treating both the symptoms and root causes and taking into account all aspects, concurrently giving appropriate psychological intervention can it be effective.
2020 Vol. 27 (23): 148-151 [Abstract] ( 43 ) HTML (40 KB)  PDF  (0 KB)  ( 6 )
152 Influence of "Fuzheng Butu" acupuncture combined with Xuefu Zhuyu Decoction on intracranial hemodynamics, lower limb muscle strength and balance in patients with hemiplegia due to cerebral infarction
OUYANG Yu-juan；LI Bo
Objective To investigate the influence of "Fuzheng Butu" acupuncture combined with Xuefu Zhuyu Decoction on intracranial hemodynamics, lower extremity muscle strength and balance in patients with hemiplegia due to cerebral infarction.Methods The clinical data of 89 patients with cerebral infarction hemiplegia admitted to Jiahe Hospital of Liaoning Traditional Chinese Medicine from October 2018 to December 2019 were retrospectively collected,and they were divided into the control group (n=43) and the experimental group (n=46) according to different treatment methods.Both groups were given routine rehabilitation training, and the control group was given "Fuzheng Butu"acupuncture method, the experimental group was treatment with Xuefu Zhuyu Decoction on the base of the control group.Both groups were treated for 14 days for 1 course.After 2 courses of treatment, the intracranial hemodynamics and lower limb muscle strength and balance were compared between the two groups.Results After treatment, the peak systolic blood flow velocity (Vs), end-diastolic blood flow velocity (Vd), and average blood flow velocity (Vm) in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05).After treatment, the lower limb muscle strength of the experimental group was better than that of the control group, and the Berg balance scale (BBS) score in the experimental group was higher than that in the control group, the differences were statistically significant (P＜0.05).Conclusion "Fuzheng Butu" cooperation with acupuncture in the treatment of patients with hemiplegia due to cerebral infarction can improve cerebral hemodynamics, improve lower extremity muscle strength and balance function.
2020 Vol. 27 (23): 152-154 [Abstract] ( 36 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
155 Effect of Peiyuan Tongnao Capsule in the treatment of recovery stage of stroke and its influence on nerve function, balance function and daily living ability
WU Qiang
Objective To explore the effect of Peiyuan Tongnao Capsules in the treatment of recovery of stroke and its influence on neurological function, balance function and daily living ability.Methods A total of 62 cases of stroke patients in recovery stage who were treated in our department from January 2018 to December 2019 were selected and randomly divided into the treatment group (31 cases) and the control group (31 cases) according to random number table methods, 31 cases in each group.The control group received Naoxintong Capsules treatment on the basis of Western medicine and rehabilitation treatment, while the treatment group received Peiyuan Tongnao Capsules treatment on the basis of Western medicine and rehabilitation treatment, every 30 days as a course of treatment.The clinical effective rate, the scores of national institute of health stroke scale (NIHSS score), Berg balance scale (Berg score) and Barthel index (Barthel score) of the two groups were comprehensively evaluated.Results The total effective rate in the treatment group was 87.1%, which was higher than that of the control group accounting for 64.5%, the difference was statistically significant (P＜0.05).Before treatment, there were no significant differences in NIHSS, Berg and Barthel scores between the two groups (P＞0.05).After treatment, the score of NIHSS in the treatment group was lower than that of the control group, and the scores of Berg and Barthel in the treatment group were higher than those of the control group, the differences were statistically significant (P＜0.01).Conclusion Peiyuan Tongnao Capsules can significantly improve the neurological function and balance function of patients in the recovery stage of stroke, and improve their ability of daily life as well.It has a remarkable therapeutic effect.
2020 Vol. 27 (23): 155-158 [Abstract] ( 99 ) HTML (35 KB)  PDF  (0 KB)  ( 6 )
159 Application effect of PDCA cycle in specimen quality control before examination and analysis
FAN Han-gong；ZHUO Jian-zhen；YUAN Chun-lei；XIANG Yan-qun；HUANG Xiang；WEI Qing-ling
Objective To explore the application effect of PDCA cycle in specimen quality control before examination and analysis.Methods A total of 937 423 specimens received by the laboratory of our hospital from July to December 2017 were selected as the control group, 984 940 specimens received by the laboratory from July to December 2018 were selected as the observation group.In the control group, PDCA cycle was not implemented in the specimen quality control before the examination and analysis, while in the observation group, PDCA cycle was implemented in the specimen quality control before the examination and analysis.The unqualified rate of specimens, the unqualified rate of different specimen types and the unqualified rate of specimens sent by different departments were compared between the two groups.The main types of unqualified specimens in the two groups, the top three clinical departments and the corresponding unqualified specimen rate were analyzed.Results The unqualified rate of specimens in the observation group was 0.079%, which was lower than that in the control group (0.087%), the difference was statistically significant(P＜0.05).The unqualified rates of cord blood and serum specimens in the observation group were lower than those in the control group, and the unqualified rate of whole blood specimens in the observation group was higher than that in the control group, the differences were statistically significant (P＜0.05).The unqualified rate of pediatric inpatient and obstetric inpatient specimens in the observation group were lower than those in the control group, and the unqualified rate of the first area of newborn inpatient specimens in the observation group was higher than that in the control group, the differences were statistically significant (P＜0.05).The incidence rates of anticoagulant specimens agglutination of obstetric inpatient and pediatric inpatient specimens in the observation group were lower than those in the control group, and the incidence rate of anticoagulant specimens agglutination in the first area of newborn in the observation group was higher than that in the control group, the difference were statistically significant (P ＜0.05).There were no significant differences between the two groups in the incidence rates of small number of specimens in the first area of newborn, pediatric inpatient and surgical inpatient specimens (P＞0.05).The incidence rate of the inconsistency between the test items and the specimens in the first area of newborn specimens in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05).There was no significant difference in the two groups in the incidence of inconsistency between test items and specimens of internal medicine inpatient and obstetric inpatient (P＞0.05).There were no significant differences between the two groups in the incidence rates of specimens sending container errors in the specimens of internal medicine inpatient, surgical inpatient and pediatric inpatient (P＞0.05).Conclusion Applying PDCA cycle management to clinical examination quality control can further reduce the unqualified rate of specimens, and the laboratory should normalize the PDCA cycle.
2020 Vol. 27 (23): 159-163. [Abstract] ( 44 ) HTML (45 KB)  PDF  (0 KB)  ( 7 )
164 Diagnostic value of combined detection of serum alpha-fetoprotein, α-Lfucosidase, carcinoembryonic antigen and glycoprotein antigen 19-9 for liver cancer
XU Hong-jun
Objective To analyze the diagnostic value of combined detection of serum alpha-fetoprotein (AFP), α-Lfucosidase (AFU), carcinoembryonic antigen (CEA) and glycoprotein antigen 19-9 (CA19-9) for liver cancer.Methods The clinical data of 136 patients with liver disease treated in our hospital from January 2015 to October 2019 were retrospectively analyzed.According to the results of pathological examination, the clinical data of 64 patients with primary liver cancer were selected as the observation group, the clinical data of 72 patients with non-neoplastic liver disease were selected as the control group.The levels of AFP,AFU,CEA and CA19-9 were detected by fully automated immunochemiluminescence analyzer and automatic biochemical analyzer.The levels of AFP, AFU, CEA and CA19-9 were compared in the two groups.The pathological examination results were used as the gold standard, and the combined diagnostic accuracy, specificity and sensitivity of each index were calculated.Results The levels of AFP, AFU, CEA and CA19-9 in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).The diagnostic sensitivity (90.63%) and accuracy (90.44%) of AFP+CEA+AFU were higher than those AFP+CA19-9+CEA (67.19%, 77.21%), AFP+CA19-9+AFU (67.19%, 75.74%), CA19-9+CEA+AFU (64.06%, 74.26%),the differences were statistically significant (P＜0.05).There were no significant differences in diagnostic sensitivity,specificity and accuracy between AFP+CEA+AFU and AFP+CA19-9+CEA+AFU (P＞0.05).Conclusion The combined detection of AFP, CEA and AFU can be used in the screening of liver cancer, which is helpful to improve the diagnostic efficiency of liver cancer, and thus provide guidance for the diagnosis and treatment of liver cancer, and reduce the risk of missed diagnosis and misdiagnosis.
2020 Vol. 27 (23): 164-166 [Abstract] ( 37 ) HTML (31 KB)  PDF  (0 KB)  ( 7 )
167 Study of the relationship between mental health levels and coping styles of patients with malignant bone tumor
DUAN Liu-hua
Objective To explore the relationship between mental health levels and coping styles of patients with malignant bone tumors.Methods Totally 90 patients with malignant bone tumor who were treated in our hospital from January 2017 to January 2020 were selected as the study group, and 90 healthy persons who underwent routine physical examination in our hospital during the same period were selected as the control group.The psychological status of the two groups was compared, and the correlation between the psychological status of patients with malignant bone tumor and their coping styles, as well as the influence of coping styles and mental health levels on their survival state were analyzed.Results The scores of paranoia, obsessive-compulsive symptoms, somatization, hostility, terror, sensitivity of interpersonal relationship, psychoticism, depression, and anxiety in the study group were all higher than those of the control group, and the differences were statistically significant (P＜0.05).The scores of patients coping with the disease in escaping, facing and yielding were (13.26±2.72) points, (13.25±3.41) points, (15.99±3.22) points, respectively.Obsessive-compulsive symptoms, somatization, hostility, terror, sensitivity of interpersonal relationship, depression, and anxiety of patients with malignant bone tumors were positively correlated with yielding (r=0.316, 0.319, 0.406, 0.389,0.430, 0.320, 0.398, P=0.046, 0.045, 0.049, 0.031, 0.020, 0.045, 0.023).Paranoia, hostility, terror, sensitivity of interpersonal relationship, psychoticism, and anxiety were positively correlated with escaping (r=0.331, 0.311, 0.309, 0.303,0.320, 0.306, P =0.029, 0.031, 0.032, 0.038, 0.029,0.033).Paranoia, obsessive-compulsive symptoms, sensitivity of interpersonal relati onship, psychoticism, depression,and anxiety were negatively correlated with facing,(r=-0.317,-0.346,-0.348,-0.337,-0.404,-0.352, P=0.039,0.042, 0.040, 0.034, 0.026, 0.032).PIHS score ≥45 points was designated as poor survival state, PIHS score ＜45 points was as good survival state.In those 90 cases with malignant bone tumor, 50 cases were in poor survival state and the rest were in good survival state.The scores of paranoia, obsessive-compulsive symptoms, hostility, terror, sensitivity of interpersonal relationship, psychoticism, depression, anxiety, yielding, and escaping in the good survival state group were lower than those in the poor survival state group, the score of facing in the good survival state group was higher than that in the poor survival state group, and the differences were statistically significant (P＜0.05).Conclusion Patients with malignant bone tumor have poor mental health, their mental health levels have obvious correlation with their coping styles.Coping negatively and negative emotions will directly affect the survival state of patients, which are not conducive to recovery.
2020 Vol. 27 (23): 167-170 [Abstract] ( 40 ) HTML (34 KB)  PDF  (0 KB)  ( 6 )
171 Investigation analysis of labeling on drug use for pregnant and lactating women in 161 kinds of traditional Chinese patent medicine
YU Li-Jun；MA Shi-yu
Objective To investigate and analyze the medication labeling of pregnant and lactating women in the manual of traditional Chinese patent medicine from Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine (referred to as the "Ruijin Hospital"), and to provide the reference for further strengthening the rational medication of pregnant and lactating women, and guiding the safe medication of pregnant and lactating women.Methods A total of 161 instructions for traditional Chinese patent medicine from the pharmacy of Ruijin Hospital in January 2019 were collected, the medication labeling of pregnant and lactating women was statistically analyzed.The comparisons were made according to different classification methods, and the "medical formulations" under the 2015 version of the Pharmacopoeia of the People′s Republic of China (referred to as the "Chinese Pharmacopoeia") (425-1748 pages) regarding the labeling of pregnant and lactating women.Results Of the 161 drug instructions, 44 of them were clearly marked as prohibited, 9 of them were taboo, 35 of them were used with caution, 15 of them were should be used under the guidance of doctors, and 58 of them were unclear.There were 17 species that were banned by the Chinese Pharmacopoeia, 8 species were forbidden, and 15 species were used with caution.A total of 17 of them were listed by the Chinese Pharmacopoeia as prohibited, 8 of them were taboo, 15 of them were cautious, and 50 of them were not mentioned in the Chinese Pharmacopoeia.There were still 71 kinds of traditional Chinese patent medicine not listed in the Chinese Pharmacopoeia.In addition, the 20 kinds of Chinese patent medicines included in the pregnancy drug identification information didn′t match the pregnancy medication information in the instructions.In the instructions of traditional Chinese patent medicine, 45.3% of them were unclear in safety of medication for pregnant women, 31.1% of them were not mentioned in the Chinese Pharmacopoeia about safety of medication for pregnant women, and only 12.4% of them included in the Chinese Pharmacopoeia about safety of medication for pregnant women didn′t match the pregnancy medication information in the instructions.Conclusion In the actual use of traditional Chinese patent medicine, the information about pregnancy medication labeling is unclear or not mentioned or does not match the information contained in the Chinese Pharmacopoeia.The three parties of the State Food and Drug Administration,drug manufacturing enterprises and medical and health institutions should pay enough attention to it and actively take corresponding measures to improve it, so as to guide the clinical safe use of drugs.
2020 Vol. 27 (23): 171-175转179 [Abstract] ( 40 ) HTML (42 KB)  PDF  (0 KB)  ( 6 )
176 Exploration on the early identification of medical risks in the application of medical safety management
LI Qing-hua；ZHU Chang-cong； CHEN Chen
Medical risks are affected by factors such as personnel behavior, hospital systems, procedures, drugs, equipment, and environmental facilities, and are present in the entire process of patient visits.This paper focused on the current status and explored the problems of medical risk identification, and applied information technology to monitor and identify medical risks, and internal control inspections and external observations to identify medical risks.Through the practice of early identification of medical risks, explore ways to perfect the content of specialized medical risk identification, improve the ability to recognize or identify risks, and strive to achieve early detection and intervention of medical risks, ensure medical safety, and promote the sustainable and healthy development of hospitals.
2020 Vol. 27 (23): 176-179 [Abstract] ( 26 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
180 Management practice of COVID-19 isolation ward in primary hospital
CHEN Yin-juan；LAN Jing； ZHENG Chun-cui
This article summarizes the experience of the construction and management of COVID-19 isolation ward in our hospital.The establishment of the COVID-19 isolation ward, the implementation of COVID-19 guidelines and workflow training for nursing staff, and the management of patients and medical waste were mainly described.Through strict training, the nursing staff have mastered various nursing skills, in order to do the protection work and to care patients well.The preliminary results are expected to provide reference for other wards to fight against the epidemic.
2020 Vol. 27 (23): 180-182 [Abstract] ( 33 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
183 Application effect of PDCA cycle management model on the party construction of the hospital
CAO Qian
Objective To summarize the application effect of Plan-Do-Check-Act (PDCA) cycle management mode on the party construction of the hospital, and provide theoretical guidance for further deepening party construction in hospital.Methods From January to December in 2017, our hospital adopted the routine method to carry out party construction, which was selected as a control group;from January to December in 2018, the PDCA cycle management mode was used in party construction, which was selected as an observation group.The attendance rate of meeting, the passing rate of theory assessment, the rate of satisfaction of hospital staff for hospital management, and the hospital party cadres′ practice evaluation score between the two groups were compared.Results The attendance rate of meeting and the passing rate of theory assessment in the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05);the total satisfaction of hospital management and the hospital party cadres′ practice evaluation score in the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05).Conclusion Applying the PDCA cycle management mode to the party construction in hospitals can improve the enthusiasm of party members and cadres to participate in party construction, it also can improve their theoretical knowledge and practice of party construction, and increase stuff′s rate of satisfaction on the hospital management.
2020 Vol. 27 (23): 183-185 [Abstract] ( 47 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
186 Effect of antimicrobial stewardship on the rationality of antimicrobial use in perioperative period of type Ⅰincision surgery
LIU Zhang-sheng；LIAO Yuan-yue；LI Jia-hong
Objective To explore the effect of antimicrobial stewardship on the rationality of antimicrobial use in perioperative period of type Ⅰincision surgery.Methods From April 2018 to November 2019, 300 inpatients who underwent type Ⅰincision surgery in our hospital were selected as the research objects.January 2019 was taken as the official practice point of antimicrobial stewardship.From April to December 2018, the 148 patients admitted to our hospital were considered as before management, and the 152 patients from January to November 2019 were treated as after management.The proportion of antimicrobial use before and after antimicrobial stewardship and the prophylactive use of antibacterial drugs in patients with type I incision surgery were compared.Results After the implementation of management, the use rate of antimicrobial drugs for type I incision surgery decreased from 79.73% (118/148) before management to 21.71% (33/152), the difference was statistically significant (P＜0.05).The type of preventive use of antibacterial drugs in the perioperative period before antibacterial stewardship was mainly the first and third generation cephalosporins, and there was a phenomenon of drug combination.After management of antibacterial stewardship, the first and second generation cephalosporins took the majority without joint use, and the use rate of the first, second and third generation cephalosporins after management, compared with before management, the differences were statistically significant (P＜0.05).For other antibacterial drugs, there was no significant difference in use rate before and after management (P＞0.05).After management of antibacterial stewardship, the clinical selection of drug varieties, the duration of drug administration, and the reasonable rate of drug administration were higher than those before the management, and the rate of medication without indication, improper usage and dosage, and inappropriate choice of solvent were lower than those before the management, the differences were statistically significant (P＜0.05).Conclusion The implementation of antimicrobial stewardship can significantly increase the rationality of the use of antimicrobial drugs in the perioperative period of type Ⅰincision surgery, and effectively improve the quality evaluation of the antimicrobial stewardship process, thereby ensuring the safety of patients′ medication.
2020 Vol. 27 (23): 186-189 [Abstract] ( 35 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
190 Application effect of out-of-hospital continuous diet intervention on patients undergoing gastrointestinal surgery
XIA Qiu-yan；JIN Ying
Objective To explore application effect of out-of-hospital continuous diet intervention on patients undergoing gastrointestinal surgery.Methods Seventy patients with gastrointestinal surgery received in our hospital from April 2017 to August 2018 were selected as research objects, and they were divided into control group (n=35) and nursing group (n=35) according to random number table method.Patients in the control group were received routine nursing measures, and the nursing group was given out-of-hospital continuous diet intervention on the basis of the control group.The nutritional indicators, functional rehabilitation effects and complications of the two groups of patients were compared.Results After 6 months of nursing, the hemoglobin, red blood cell count, and body mass index of the two groups were higher than those before the nursing, and the above indexes in nursing group were higher than those of the control group, the differences were statistically significant (P＜0.05);the total excellent rate of functional rehabilitation in the nursing group was 91.43%, higher than 68.57% of the control group, the difference was statistically significant(P ＜0.05);total complications of obstruction, gastrointestinal bleeding, nausea and vomiting, and palpitations in the nursing group were lower than those in the control group, the differences were statistically significant (P＜0.05).Conclusion Out-of-hospital continuous diet intervention for patients with gastrointestinal tract surgery has good clinical effect.It can improve the nutrition index during the rehabilitation of patients, promote the rehabilitation of gastrointestinal function after surgery, reduce the incidence of postoperative complications, and promote the early recovery of patients.It is worthy of clinical promotion.
2020 Vol. 27 (23): 190-192 [Abstract] ( 28 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
193 Application of empowerment theory in the nursing of patients with upper airway cough syndrome
SUN Jing；CHEN Guo-yan
Objective To explore the application effect of empowerment theory in the nursing of patients with upper airway cough syndrome (UACS).Methods A total of 68 UACS patients treated in Affiliated Hospital of Qingdao University from January 2017 to October 2018 were selected as research subjects.They were divided into control group and observation group by random number table method, 34 cases in each group.In the control group, conventional nursing was used, and in the observation group, empowerment theory nursing on the basis of conventional nursing was adopted.The scores of quality of life scale, self-rating anxiety scale, self-rating depression scale, and the unplanned rehospitalization rate were compared between the two groups after six months of nursing.Results After intervention, the score of quality of life scale in the observation group was (59.31±4.11) points, higher than that of the control group, which was(38.83±5.62) points;the score of self-rating anxiety scale was (27.22±2.31) points, lower than that of the control group,which was (47.11±2.01) points;the score of self-rating depression scale was (25.33±3.11) points, lower than that of the control group, which was (49.23±2.11) points, with statistical differences (P＜0.05).The unplanned rehospitalization rate of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion Applying empowerment theory nursing to patients with UACS can promote their psychological selfadjustment, improve their quality of life and the prognosis of disease.
2020 Vol. 27 (23): 193-195 [Abstract] ( 44 ) HTML (34 KB)  PDF  (0 KB)  ( 8 )
196 Application effect of predictive nursing in the prevention of falls of inpatients with psychosis
CHEN Ze-qun； HUANG Ju-juan；JIANG Jian-mao；CAO Yun-zhen；CHEN Ze-ying；WU Guang-bing
Objective To explore the application effect of predictive nursing in the prevention of falls of inpatients with psychosis.Methods A total of 90 psychiatric patients treated in Mental Hospital of Guangzhou Civil Affairs Bureau from May 2018 to May 2019 were selected, and they were divided into two groups according to the random number table method: predictive nursing group (n=45) and routine nursing group (n=45).The fall risk factors, the incidence of falls and quality of care in patients of the two groups were analysed.Results There were no significant differences between fall history in the last 3 months, number of disease diagnosis, walking needs, drug treatment, gait and movement,and mental state score between the two groups of patients (P＞0.05).The incidence of 1 fall, ≥2 falls, and the total falls in the predictive nursing group were 2.2% (1/45), 2.2% (1/45) and 4.4% (2/45), lower than those in the routine nursing group of 1.1% (5/45), 8.9% (4/45) and 20.0% (9/45), and the differences were statistically significant (P＜0.05).Patients in the predictive nursing group implemented fall prevention measures, formulated and implemented anti-fall measures,anti-fall care records, patient and nurse awareness, and ward management scores were higher than those in the routine nursing group, with statistical differences (P＜0.05).Conclusion The application effect of predictive nursing is better than that of routine nursing in the prevention of falls of inpatients with psychosis.
2020 Vol. 27 (23): 196-198 [Abstract] ( 38 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
199 Application of modified lower limb exercise in cardiovascular intervention and its effect on compliance
XIAO Yan；CHEN Ying；SHU Min
Objective To investigate the application of modified lower limb exercise in cardiovascular intervention and its effect on compliance.Methods A total of 200 patients who underwent cardiovascular intervention in our hospital from July 2018 to June 2019 were selected, and they were divided into two groups according to random number table method, 100 cases in each group.The patients in control group were received routine postoperative nursing and the patients in observation group were received modified lower limb exercise based on control group.The scores of verbal rating scale (VRS), Pittsburgh sleep quality index (PSQI) scores and compliance were compared between two groups.Results The VRS pain rating scale of observation group was better than that of control group, and the difference was statistically significant (P＜0.05).There was no statistical difference in the scores of PSQI scale between two groups before nursing (P＞0.05);the scores of PSQI scale in two groups after nursing were lower than those before nursing, and observation group was lower than that of control group after nursing, and the differences were statistically significant (P＜0.05）.The total compliance rate of observation group （94.00%） was higher than that of control group （82.00%）, and the difference was statistically significant （P＜0.05）.Conclusion Modified lower limb rehabilitation exercise is easy to learn, it has good effects on improving the sleep quality and compliance of patients after cardiovascular intervention,and is conducive to reducing the pain, which can be promoted and applied to all patients who meet the rehabilitation exercise indications after cardiovascular intervention.
2020 Vol. 27 (23): 199-201 [Abstract] ( 29 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
202 Effect of comprehensive nursing intervention on the expression of BDNF and Cor in patients with depression of different genders
QIU Xue-lan；LIN Cai-feng；WANG Zhen-yan；YIN Feng-lian
Objective To investigate the effects of comprehensive nursing intervention on the expression of brain-derived neurotrophic factor (BDNF) and cortisol (Cor) in patients with depression of differen genders.Methods A total of 60 patients with depression who were admitted to our hospital from August 2018 to August 2019 were selected as resear ch subjects.They were divided into control group and study group according to the random number table method,30 cases in each group.The control group u nderwent routine nursing intervention, and the study group implemented comprehensive nursing intervention for a period of 8 weeks.The expression levels of B DNF and Cor were compared between the two groups of patients with different genders before and after intervention.Results The expression of BDNF and Cor in the study group was not significantly different from those in the control group before intervention (P＞0.05).The expression level of BDNF i n male and female in the study group were (29.86±4.02) and (27.78±3.35) pg/ml, higher than those of the control group of (26.14±3.71) and (24.36±3.29) pg/ml, after interven tion, the expression levels of BDNF in male and female patients were higher than those before intervention, with significant differences (P＜0.05).The Cor expression levels of the study group in males and females were (84.03±13.81) and (86.64±14.07) pg/ml, which were lower than those of the control group of (97.56±14.52) and (100.12±15.92) pg/ml, the expression levels of Cor in male and female patients after intervention were lower than those before intervention, with significant differences (P＜0.05).Conclusion The effect of comprehensive nursing in tervention was significant in patients with depression of different genders, which could improve the expression level of BDNF and Cor.
2020 Vol. 27 (23): 202-204转208 [Abstract] ( 35 ) HTML (34 KB)  PDF  (0 KB)  ( 5 )
205 Application effect of comprehensive nursing intervention in laparoscopic repair of indirect inguinal hernia in children
XIAO Min；CAI Qi；LI Li-hui；LIU Hai-jin；LIU Hua-zhi
Objective To explore application effect of comprehensive nursing intervention on laparoscopic indirect inguinal hernia repair in children.Methods A total of 80 children with indirect inguinal hernia in our hospital from November 2016 to July 2018 were selected as the research objects, the patients were divided into two groups by random number table method, 40 cases in each group.The routine group was given routine nursing intervention, and the comprehensive group was given comprehensive nursing intervention.The changes of clinical indicators, parents′ satisfaction with nursing and the incidence of complications between the two groups were compared.Results The bleeding volume of children in the comprehensive group was less than that in the routine group, and the operation time, anal exhaust time and hospitalization time were shorter than those in the routine group, and the differences were statistically significant (P＜0.05).The total satisfaction of parents in the comprehensive group was higher than that in the routine group, the total incidence of complications in the comprehensive group was less than that in the routine group, and the differences were statistically significant (P＜0.05).Conclusion Laparoscopic indirect inguinal hernia repair in children with comprehensive nursing interventions can reduce the amount of intraoperative bleeding, shorten the operation time,anal exhaust time and hospitalization time, improve parents′ nursing satisfaction, reduce complications.
2020 Vol. 27 (23): 205-208 [Abstract] ( 40 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
209 Application effect of optimized perioperative nursing in the pulsed radiofrequency treatment for post-herpetic neuralgia
LIU Li-zhen；ZHONG Yu-hua；LIN Zhao-zhong
Objective To observe the application effect of optimized perioperative nursing in the pulsed radiofrequency treatment for post-herpetic neuralgia (PHN).Methods A total of 94 patients with PHN treated by pulsed radiofrequency in Yong′an General Hospital of Sanming City, Fujian Province from January 2014 to December 2016 were selected and divided into observation group and control group according to random number table method, 47 cases in each group.The control group was given routine perioperative nursing, and the observation group was provided with targeted optimized nursing on the basis of routine perioperative nursing.The scores of visual analogue scale (VAS), Pittsburgh sleep quality index (PSQI), anxiety and depression scales and the MOS 36-item short form health survey (SF-36) were observed at 1 week, 1, 3 and 6 months after intervention to evaluate the degree of pain, sleep quality, emotional status and the quality of life of patients.Results The score of PSQI in the observation group after intervention was lower than that of the control group (P＜0.05).The anxiety and depression scores in the observation group intervention were lower than those of the control group (P＜0.05).The score of SF-36 in the observation group after intervention was higher than that of the control group, with statistical differences (P＜0.05).Conclusion Applying optimized perioperative nursing to patients with PHN who received pulsed radiofrequency treatment can significantly alleviate their pain and improve their sleep quality, emotional state, and life quality.
2020 Vol. 27 (23): 209-212转216 [Abstract] ( 32 ) HTML (44 KB)  PDF  (0 KB)  ( 6 )
213 Application of holistic nursing combined clinical nursing pathway in the nursing of vitreous cavity injection
DING Ri-hua
Objective To analyze the application of holistic nursing combined clinical nursing pathway in the treatment of vitreous cavity injection surgery.Methods A total of 60 patients with vitreous cavity injection surgery who were admitted to our hospital from July 2017 to July 2018 were selected and divided into observation group (n=30) and control group (n=30) according to random number table method.The control group received routine nursing and the observation group used holistic nursing and clinical nursing pathway.The postoperative 7 day visual acuity, nursing quality score,disease cognitive score, nursing satisfaction score, and psychological status score were compared between the two groups.Results The total incidence of complications in the observation group was 10.00%, which was lower than that in the control group (30.00%), the difference was statistically significant (P＜0.05).The visual acuity of the observation group was better than that of the control group, the difference was statistically significant (P＜0.05).The nursing quality score of the obeservation was (92.03±7.17) points, the disease cognition score was (86.45±5.96) points, and the nursing satisfaction score was (93.13±5.22) points, higher than those of the control group of (85.14±10.35), (70.05±7.57) and(85.78±11.04) points, the differences were statistically significant (P＜0.05).The anxiety self-assessment scale (SAS)score and the depression self-assessment scale (SDS) scores of the two groups after nursing were lower than those before the nursing, and the differences were statistically significant (P＜0.05).The observation group SAS score, SDS score after nursing score were lower than those of the control group, the differences were statistically significant (P＜0.05).Conclusion Patients with vitreous cavity injection surgery give holistic nursing and clinical nursing pathways, which can effectively improve the quality of care and improve satisfaction, reduce complications, alleviate patients′ bad mood,and have high clinical value.
2020 Vol. 27 (23): 213-216 [Abstract] ( 43 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
217 Application effect of perioperative nursing intervention on patients with ectopic pregnancy during perioperative period
MA Li
Objective To explore the application effect of perioperative nursing intervention in patients with ectopic pregnancy.Methods Sixty patients with ectopic pregnancy who were treated in our hospital from July 2018 to June 2019 were selected as the research objects.They were divided into the observation group (n=30) and the control group(n=30) according to the odd and even grouping method.The control group was used the conventional nursing mode, the observation group was used whole-course nursing intervention, Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA) scores, comprehensive quality of life questionnaire-74 (GQOL-74) scores, and satisfaction with nursing work in the two groups were compared.Results The scores of HAMD and HAMA in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05).The score of the GQOL-74 scale in the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).The total satisfaction of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion The implementation of full-course nursing intervention for patients with ectopic pregnancy to achieve good nursing effect can help patients adjust their mental state, improve quality of life scores at the same time, and maintain a harmonious relationship between nurses and patients, worthy of clinical application
2020 Vol. 27 (23): 217-219 [Abstract] ( 34 ) HTML (29 KB)  PDF  (0 KB)  ( 6 )
220 Application of predictive nursing intervention in puerperants undergoing natural childbirth
LYU Wei
Objective To explore the application of nursing intervention in prevention of postpartum hemorrhage for puerperants undergoing natural childbirth.Methods Altogether 110 cases of puerperants undergoing natural childbirth who were diagnosed and treated at Dalian Municipal Women and Children′s Medical Center from September 2016 to June 2019 were retrospectively analyzed and divided into two groups according to different nursing methods: the control group (n=55) adopted conventional nursing mode;the study group (n=55) adopted predictive nursing intervention.The postpartum hemorrhage rate, hemorrhage volume at different postpartum periods, and differences in subjective nursing experience were compared between the two groups.Results The incidence of postpartum hemorrhage in the study group was lower than that in the control group, with statistical difference (P＜0.05).The hemorrhage volume in the study group at postpartum 2 and 24 h were less than those in the control group, with statistical differences (P＜0.05).The excellent rate of subjective nursing experience of puerperants in the study group was higher than that in the control group, with statistical difference (P＜0.05).Conclusion Implementation of predictive nursing interventions for puerperants undergoing natural childbirth can effectively prevent postpartum hemorrhage, reduce the postpartum hemorrhage volume, and improve the patients′ subjective nursing experience, which is recommended as the first choice of nursing for puerperants undergoing natural childbirth.
2020 Vol. 27 (23): 220-222 [Abstract] ( 38 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
223 Application effect of holistic nursing in patients with bronchial asthma
SUN Hong-yun
Objective To investigate application effect of the holistic nursing in patients with bronchial asthma.Methods A total of 68 patients with bronchial asthma treated in our hospital from August 2017 to August 2019 were selected as the research objects.According to the alternating grouping method, they were divided into reference group (n=34)and nursing group (n=34).The reference group was adopted conventional nursing method, and the nursing group was adopted holistic nursing method.The changes in anxiety and depression, lung function improvement, and quality of life before and after nursing in the two groups were compared.Results Before nursing, there were no significant differences in the anxiety self-rating scale (SAS) and depression self-rating scale (SDS) between the two groups of patients (P＞0.05).After nursing, the SAS and SDS scores of the patients in the nursing group were lower than those in the reference group, and the differences were statistically significant (P＜0.05).Before nursing, there was no significant difference in pulmonary function indicators (arterial oxygen saturation [SaO2], peak expiratory flow rate [PEF]) between the two groups of patients (P＞0.05).After nursing, the levels of SaO2 and PEF in the nursing group were higher than those in the reference group, and the differences were statistically significant (P＜0.05).Before nursing, there was no significant difference in the scores of the asthma quality of life questionnaire (AQLQ) between the two groups of patients (P＞0.05).After nursing, the AQLQ scores of asthma symptoms, limited mobility, physiological status, self-health concerns, and response to stimulus sources in the nursing group were higher than those in the reference group, and the differences were statistically significant (P＜0.05).Conclusion The advantages of holistic nursing in the nursing of bronchial asthma patients are more obvious, which can significantly improve patients′ anxiety and depression, improve their lung function and improve their quality of life, which is worthy of clinical promotion.
2020 Vol. 27 (23): 223-226 [Abstract] ( 39 ) HTML (35 KB)  PDF  (0 KB)  ( 5 )
227 Effect of comprehensive nursing on health status questionnaire score and activity of daily living scale score of diabetic nephropathy patients undergoing maintenance hemodialysi
ZHANG Ying
Objective To explore the effect of comprehensive nursing on the scores of health status questionnaire (SF-36) and activity of daily living scale (ADL) of patients with diabetic nephropathy (DN).Methods 60 cases of DN treated by maintenance hemodialysis (MHD) in our hospital from January 2018 to January 2019 were selected as the research objects.According to the random number table method, they were divided into control group (n=30) and observation group (n=30).The control group carried out traditional nursing, and the observation group carried out full-scale nursing.ADL and SF-36 score were compared between the two groups.Results After 1 month of nursing, ADL score grade in the observation group was better than that in the control group, the difference was statistically significant (P＜0.05).The SF-36 score of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion The comprehensive nursing intervention can improve the quality of life and the ability of daily life of the patients with DN treated by MHD.
2020 Vol. 27 (23): 227-230 [Abstract] ( 38 ) HTML (33 KB)  PDF  (0 KB)  ( 8 )
231 Application effect of whole course high quality nursing in elderly patients with acute myocardial infarction
CAO Rui
Objective To explore the application effect of whole course high quality nursing intervention in elderly patients with acute myocardial infarction (AMI).Methods A total of 61 elderly patients with AMI treated in our hospital from January to June 2018 were selected, and routine nursing was taken as the control group.In July 2018, the department of cardiology of our hospital carried out the whole course high quality nursing.A total of 64 elderly patients with AMI were admitted as the experimental group (from July to December 2018), and the two groups were followed up for one year.The incidence of complications, nursing quality score, length of stay, recurrence during follow-up and the rate of re-intervention were compared between the two groups.Results The total incidence of complications in the experimental group was lower than that in the control group (P＜0.05).The nursing quality score of the experimental group was higher than that of the control group (P＜0.05).During the follow-up period, the recurrence rate in the experimental group was lower than that in the control group, and the rate of re-intervention in the experimental group was lower than that in the control group, the differences were statistically significant (P＜0.05).Conclusion High quality nursing intervention in the whole process of elderly AMI can reduce the complications, improve the quality of nursing, reduce the recurrence, and provide a new nursing direction for clinical nursing.
2020 Vol. 27 (23): 231-233 [Abstract] ( 40 ) HTML (30 KB)  PDF  (0 KB)  ( 6 )
234 Application of perioperative nursing in elderly patients undergoing laparoscopic radical resection of colorectal cancer
CHENG Yuan
Objective To explore the application of perioperative nursing in elderly patients undergoing laparoscopic radical resection of colorectal cancer.Methods Altogether 64 elderly patients who underwent laparoscopic radical resection of colorectal cancer in our hospital from May 2017 to May 2018 were selected and divided into observation group and control group according to the random number table method, 32 cases in each group.The observation group received perioperative nursing, and the control group adopted routine nursing.The pre-and post-treatment comfort,psychological status and quality of life were compared between the two groups.Results Before nursing, no statistically significant difference was seen in the anxiety self-assessment scale (SAS) and depression self-assessment scale (SDS)scores between the two groups (P＞0.05).After nursing, the SAS and SDS scores in observation group were lower than those in the control group, with statistical differences (P＜0.05).Before nursing, there was no statistically significant differences in the social interest, social ability, personal hygiene, and depression scores between the two groups (P＞0.05);the social interest, social ability, personal hygiene, and depression scores in observation group were lower than those in the control group (P＜0.05).Before nursing, there was no statistically significant difference in comfort score between the two groups (P＞0.05);after nursing, the comfort score of the observation group was higher than that of the control group,with statistical difference (P＜0.05).Conclusion Perioperative nursing shows significant effectiveness in elderly patients who underwent laparoscopic radical resection of colorectal cancer, which can reduce psychological pressure, improve comfort and the quality of life, and deservd worthy of clinical promotion.
2020 Vol. 27 (23): 234-236 [Abstract] ( 35 ) HTML (32 KB)  PDF  (0 KB)  ( 6 )
237 Effect of early rehabilitation nursing intervention in limb function and movement ability of patients with cerebral infarction hemiplegia
CHE Dan
Objective To explore the effect of early rehabilitation nursing intervention on the improvement of limb function and activity ability in patients with cerebral infarction (CIS) hemiplegia.Methods A total of 60 patients with CIS and hemiplegia admitted to our hospital from January 2018 to June 2019 were selected as research objects, and the patients were divided into two groups by random number table method, 30 cases in each group.The control group was given routine nursing, the observation group was given early rehabilitation nursing.The upper and lower limb Fugl-Meyer motor function scores FMA score and daily living ability assessment index (Barthel) before and after nursing were compared between the two groups.Results Before nursing, there were no significant differences between the two groups upper and lower limb FMA score, Barthel index (P＞0.05).The limbs and lower limbs FMA score, Barthel in the two groups after nursing were higher than those before nursing, and the upper limbs and lower limbs FMA score,Barthel in the observation group were higher than those in the control group, with statistical differences (P＜0.05).Conclusion The effect of early rehabilitation nursing intervention in patients with CIS hemiplegia is obvious，which can significantly improve the limb function and activity ability of patients.
2020 Vol. 27 (23): 237-239转243 [Abstract] ( 45 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
240 Study of ″Internet +″ WeChat platform in home care for patients after hip replacement
JIN Shao-li；SONG Xue；LI Xiao；LI Jing-shan；ZHOU Gui-qing
Objective To explore the application value of ″Internet+″ WeChat platform in home care for patients undergoing hip replacement surgery.Methods From December 2018 to September 2019, 54 patients underwent artificial hip replacement in our hospital were selected as the research subjects.The patients were divided into observation group and control group by random number table method, 27 cases in each group.Patients in the control group were provided with routine health education and telephone follow-up, and in the observation group, participants were provided with″Internet+″ WeChat platform home care.The patient′s understanding of relevant knowledge after hip surgery, hip function score, Barthel index score, and compliance behavior score were compared between two groups.Results In the observation group, the relevant knowledge scores after hip surgery 1 week, 1 and 3 months after discharge were higher than those of the control group, the differences were statistically significant (P＜0.05).In the observation group, the hip joint function scores 1 week, 1 and 3 months after discharge were higher than those of the control group, the differences were statistically significant (P＜0.05).The Barthel index scores in the observation group 1 week, 1 and 3 months after discharge were higher than that of the control group, the differences were statistically significant (P＜0.05).The compliance behavior score of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).Conclusion ″Internet+″ WeChat platform has high application value in home care for patients performed with hip replacement surgery, which can improve their understanding about relevant knowledge after hip surgery, increase the hip function score and Barthel index score, and improve patient compliance behavior score, which is worthy of clinical promotion.
2020 Vol. 27 (23): 240-243 [Abstract] ( 40 ) HTML (38 KB)  PDF  (0 KB)  ( 7 )
244 Application effect of noninvasive midwifery in improving postpartum recovery of parturients
LI Zhi-rong；MAI Jie-fen；LIU Hui-yu； XIE Shui-xiu；LIANG Hui-lan
Objective To explore the application effect of noninvasive delivery on improving the pelvic floor function and postpartum recovery.Methods A total of 168 full-term primipara with single pregnancy delivered in our hospital from August 2017 to March 2018 were selected as research subjects.The parturients were divided into observation group and control group according to random number table method, 84 cases in each group.The control group was given traditional midwifery, while the observation group was given noninvasive midwifery.The 24-hour postpartum bleeding volume, wound pain score, hospitalization time, pelvic floor muscle damage (including type Ⅰand type Ⅱmuscle fibers), stress urinary incontinence and 3-month postpartum sexual dysfunction were compared between the two groups.Results The amount of postpartum hemorrhage in the observation group was less than that in the control group, the wound pain score was lower than that in the control group, the hospitalization time was shorter than that in the control group, the incidence of stress urinary incontinence and sexual dysfunction were lower than that in the control group,and the differences were statistically significant (P＜0.05).There were no significant differences in the rates of typeⅠand type Ⅱmuscle fibers damage between the two groups (P＞0.05).Conclusion Compared with traditional midwifery,non-invasive midwifery can reduce postpartum hemorrhage, reduce wound pain, shorten hospital stay, and promote postpartum recovery.It is worth popularizing in obstetric delivery.
2020 Vol. 27 (23): 244-246 [Abstract] ( 37 ) HTML (33 KB)  PDF  (0 KB)  ( 5 )
247 Application effect of systematic cognitive therapy in clinical psychological nursing of patients with schizophrenics
DONG Xian-miao；CHEN Shu-yan；XIE Bi-xia；PENG Shu-ying；XIE Ji-qun
Objective To explore the application effect of systematic cognitive therapy in the clinical psychological care of patients with schizophrenics.Methods A total of 52 patients with schizophrenia treated in our hospital from January 2018 to October 2019 were selected.They were divided into control group and study group according to random number table method, 26 cases in each group.The study group adopted the system cognitive therapy technology on the basis of the control group, and the control group was treated with routine psychological nursing.The nursing satisfaction,brief psychiatric response scale (BPRS), insight and treatment attitude questionnaire (ITAQ), inpatient psychiatric observation scale (NOSIE) after nursing, quality of life (QOL) and total treatment compliance were analyzed between the two groups.Results The nursing total satisfaction of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05), the BPRS score of the study group after nursing was lower than that of the control group, the difference was statistically significant (P＜0.05), the ITAQ and NOSIE scores of the study group after nursing were higher than those of the control group, the differences were statistically significant (P＜0.05)，the quality of life of the study group after nursing was higher than that of the control group, the difference was statistically significant(P＜0.05), the total treatment compliance of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05).Conclusion Using the system cognitive therapy technology in the clinical psychological care of schizophrenic patients can improve the patients′ self-knowledge, improve the patients′ mental symptoms,improve the treatment compliance, improve the quality of life, also improve the nursing satisfaction, improve the relationship between doctors and patients, so it can be used in clinical practice.
2020 Vol. 27 (23): 247-249 [Abstract] ( 37 ) HTML (33 KB)  PDF  (0 KB)  ( 6 )
250 Effect of targeted nursing on self-care ability and quality of life of patients with type 2 diabetes mellitus
XIE Wen-zheng
Objective To explore the effect of targeted nursing on self-care ability and quality of life of patients with type 2 diabetes (T2DM).Methods A total of 78 patients with T2DM who treated in our hospital from January 2017 to January 2019 were selected as the study objects.They were divided into the control group and the observation group by the random number table method, 39 cases in each group.The patients in the control group received routine nursing,while those in the observation group received targeted nursing.Blood glucose level, self-care ability score and quality of life score were compared between the two groups.Results The fasting blood glucose (FPG) and postprandial blood glucose (2 h FPG) in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).Self care responsibility score, health knowledge score, self care skill score, self concept score of the observation group after intervention were higher than that of the control group, the differences were statistically significant (P＜0.05).Conclusion Targeted nursing has a positive impact on the self-care ability and quality of life of T2DM patients.It can improve the self-care ability and quality of life of patients, and has a high application value.
2020 Vol. 27 (23): 250-252 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 6 )
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