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| Analysis of related factors of early hypokalemia in acute myocardial infarction and clinical effect of targeted potassium supplementation |
| ZHAO Shi-cai |
| Department of Cardiology, Huiyang Sanhe Hospital |
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Abstract Objective To explore the related factors of early hypokalemia in acute myocardial infarction and the effect of targeted potassium supplementation therapy.Methods A retrospective analysis of 150 AMI patients admitted to our hospital was divided into hypokalemia group (n=36) and normal potassium group (n=114) according to blood potassium level.Univariate and multi-factor unconditional Logistic regression analysis were used to analysis the related risk factors affecting hypokalemia.The hypokalemia group was given normal or intensive potassium supplementation treatment,and hypokalemia patients were divided into groups A and B, 18 cases in each group.Among them, group A was given oral potassium supplement therapy, group B was combined with central intravenous potassium supplement therapy, and the changes of blood potassium concentration before treatment and after 2 to 12 h of treatment in both groups were observed.Results The single factor analysis showed that there were significant differences between the early onset of AMI and the occurrence of arrhythmia in the hypokalemia group and the normal potassium group (P＜0.05).Multi-factor unconditional Logistic regression model analysis results showed that the early onset time of AMI≤6 h (β=2.012, OR=7.480, 95%CI=1.001-9.040), atrioventricular block (β=2.032, OR=7.630, 95%CI=1.002-9.110), ventricular fibrillation and ventricular tachycardia (β=2.050, OR=7.770, 95%CI=1.006-10.153) were all independent risk factors for hypokalemia (P＜0.05).The blood potassium concentration in groups A and B after treatment at 4, 8, and 12 h were all higher than those before treatment, and the differences were statistically significant (P＜0.05);and after treatment at 4,8, and 12 h, the blood potassium concentrations in group B were higher than those in group A, the differences were statistically significant (P＜0.05).Conclusion Early onset time of AMI≤6 h, atrioventricular block, ventricular fibrillation,and ventricular tachycardia are all risk factors for hypokalemia, and targeted potassium supplementation treatment can significantly improve the early hypokalemia patients Blood potassium concentration.
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