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| Effect of Yiqi Jiedu Recipe combined with chemotherapy in the treatment of patients with advanced triple-negative breast cancer |
| QIU Zhi-min1 WANG Ling2 ZHENG Zhi3 WANG Mei-jian1 SU Yong-feng1 |
1.Department of Breast Medicine, Comprehensive Oncology
2.Department of Nursing, Jiangxi Health Vocational College
3.Department of Integrated Traditional Chinese and Western Medicine |
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Abstract Objective To investigate the effect of Yiqi Jiedu Recipe combined with chemotherapy in the treatment of patients with advanced triple-negative breast cancer.Methods Fifty-six patients with advanced triple-negative breast cancer admitted to Jiangxi Provincial Cancer Hospital from June 2018 to June 2019 were selected as the study subjects.They were divided into control group(28 cases)and research group (28 cases) according to random number table method.The control group was treated with routine chemotherapy, while the research group was treated with Yiqi Jiedu Recipe on the basis of control group.The short-term efficacy, T lymphocyte subsets (including CD4+, CD8+, CD4+/CD8+), serum tumor markers (cancer antigen 125 [CA125], carcinoembryonic antigen [CEA], cancer antigen 153 [CA153]), quality of life scores and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the research group was 85.71%, which was higher than that in the control group accounting for 53.57%,the difference was statistically significant (P＜0.05).After treatment, the levels of CD4+, CD4+/CD8+ in the research group were higher than those in the control group, with statistical significances (P＜0.05).The level of CD8+ in the research group was lower than that in the control group,with statistical significance (P ＜0.05).After treatment,the levels of CEA, CA125 and CA153 in the research group were lower than those in the control group, with statistical significances (P＜0.05).After treatment, KPS score of the research group was higher than that of the control group, with statistical significance (P ＜0.05).The incidence of thrombocytopenia, leukopenia, nausea, vomiting and alopecia in the research group was lower than that in the control group, with statistical significance (P＜0.05).Conclusion Yiqi Jiedu Recipe combined with chemotherapy is effective in the treatment of patients with advanced triple-negative breast cancer, which can effectively improve immune function, inhibit tumor markers, strengthen quality of life,and is worthy of clinical promotion.
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