血清甲胎蛋白、α-L-岩藻糖苷酶、癌胚抗原及糖链抗原19-9联合检测对肝癌的诊断价值

Abstract
Figure/Table
References (18)
Related Citation (15)

Download: PDF (0 KB) HTML (31 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To analyze the diagnostic value of combined detection of serum alpha-fetoprotein (AFP), α-Lfucosidase (AFU), carcinoembryonic antigen (CEA) and glycoprotein antigen 19-9 (CA19-9) for liver cancer.Methods The clinical data of 136 patients with liver disease treated in our hospital from January 2015 to October 2019 were retrospectively analyzed.According to the results of pathological examination, the clinical data of 64 patients with primary liver cancer were selected as the observation group, the clinical data of 72 patients with non-neoplastic liver disease were selected as the control group.The levels of AFP,AFU,CEA and CA19-9 were detected by fully automated immunochemiluminescence analyzer and automatic biochemical analyzer.The levels of AFP, AFU, CEA and CA19-9 were compared in the two groups.The pathological examination results were used as the gold standard, and the combined diagnostic accuracy, specificity and sensitivity of each index were calculated.Results The levels of AFP, AFU, CEA and CA19-9 in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05).The diagnostic sensitivity (90.63%) and accuracy (90.44%) of AFP+CEA+AFU were higher than those AFP+CA19-9+CEA (67.19%, 77.21%), AFP+CA19-9+AFU (67.19%, 75.74%), CA19-9+CEA+AFU (64.06%, 74.26%),the differences were statistically significant (P＜0.05).There were no significant differences in diagnostic sensitivity,specificity and accuracy between AFP+CEA+AFU and AFP+CA19-9+CEA+AFU (P＞0.05).Conclusion The combined detection of AFP, CEA and AFU can be used in the screening of liver cancer, which is helpful to improve the diagnostic efficiency of liver cancer, and thus provide guidance for the diagnosis and treatment of liver cancer, and reduce the risk of missed diagnosis and misdiagnosis.

Key words： Liver cancer Alpha-fetoprotein &alpha -L-fucosidase Carcinoembryonic antigen Sugar chain antigen 19-9

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	XU Hong-jun

Cite this article:

XU Hong-jun. Diagnostic value of combined detection of serum alpha-fetoprotein, α-Lfucosidase, carcinoembryonic antigen and glycoprotein antigen 19-9 for liver cancer[J]. 中国当代医药, 2020, 27(23): 164-166.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I23/164

[1]	张亚陆.lncRNA HOTTIP 调控消化系统恶性肿瘤的作用机制及其研究进展[J].中国肿瘤临床，2017，44（24）：1272-1276.
[2]	宋琦炜，张雷.微小肝癌早期诊断的临床常规影像学检查方法对照分析[J].实用放射学杂志，2017，33（12）：1943-1946.
[3]	韩笑，张喜平，魏子妤.甲胎蛋白、α-L-岩藻糖苷酶、糖类抗原199在原发性肝癌早期筛查中的作用[J].内蒙古医科大学学报，2017，39（2）：124-127.
[4]	李嘉妍，宋金云，王建芳，等.AFP、CA19-9、CEA联合检测对原发性肝癌的早期诊断价值[J].临床肝胆病杂志，2017，33（7）：1291-1295.
[5]	王军梅，莫扬.肝癌血清AFP、CEA、GGT和AFU 水平检测的临床意义[J].肝脏，2019，24（2）：208-210.
[6]	唐万峰，雪克来提·库尔班，阿合力·那斯肉拉.肝泡型包虫病肝转移与肝癌的鉴别诊断[J].中国地方病防治杂志，2016，31（8）：938-938.
[7]	吴迎澜，邓淑珍，洪欣，等.磁共振成像联合血清甲胎蛋白对原发性肝癌诊断的价值分析[J].中国当代医药，2019，26（21）：112-114.
[8]	姜林，张依娜，付君.多项肿瘤标志物联合应用对肝癌的诊断价值[J].癌症进展，2018，16（2）：199-201，238.
[9]	刘永炜，吴向民.血清AFP、CA199和CEA水平在肝癌诊断和预后中的作用[J].检验医学，2017，32（5）：406-409.
[10]	代伟伟，刘正新，徐宝宏.肝硬化和肝癌患者血清CA125、CA199、AFP和CEA水平变化[J].实用肝脏病杂志，2017，20（1）：81-84.
[11]	李晓峰，王其，童涌.甲胎蛋白异质体测定在原发性肝癌和良性肝病鉴别诊断中的应用分析[J].中国现代医生，2018，56（4）：5-7，11.
[12]	刘志野，李娜.三维适形放疗治疗原发性巨大肝癌患者的疗效及对血清AFP、AFU表达的影响[J].中国现代医生，2020，58（1）：11-14.
[13]	王虎明，巴彩霞，丽敏.血清肿瘤标志物检测对肝癌及转移患者的临床意义[J].标记免疫分析与临床，2016，23（8）：881-884.
[14]	郝磊，郝坤.血清AFP、AFU、CEA、GP73及糖链抗原系列联合检测对于早期原发性肝癌的诊断价值[J].实用癌症杂志，2017，32（10）：1609-1612.
[15]	王曦晖，蒋祖辉，周琼仙，等.血清AFP、CEA、CA125单独或联合检测对原发性肝癌早期诊断的临床价值研究[J].现代生物医学进展，2017，17（12）：156-158.
[16]	申燕军，陈京龙，李文东，等.原发性肝癌患者术前CEA和CA153与临床病理特征和预后的关系[J].医学综述，2018，24（23）：4758-4762.
[17]	鹿存芝，李向阳.甲胎蛋白联合CA199、AFU及CEA在原发性肝癌中的诊断价值[J].检验医学与临床，2017，14（10）：1412-1414.
[18]	柯昌征，王传敏，康健，等.AFP、CA19-9、SF、AFU 联合肝脏MRI 诊断原发性肝癌的效能分析[J].标记免疫分析与临床，2018，25（5）：684-688.