特应性皮炎小鼠模型中白细胞介素-21、CC趋化因子配体20的表达分析

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Abstract Objective To detect the expression of interleukin-21 (IL-21) and CC chemokine ligand 20 (CCL20) in 2,4-dinitrochlorobenzene (DNCB) induced mice models with atopic dermatitis and explore their roles in the pathogenesis of atopic dermatitis.Methods Twelve female BALB/c mice were randomly divided into the model group and control group(6 in each).Mice models with atopic dermatitis were established by DNCB.After successful modeling, the serum levels of IL-21 and CCL20 were detected by enzyme-linked immunosorbent assay(ELISA).Results The serum levels of IL-21 and CCL20 in the model group with atopic dermatitis were significantly higher than those in the control group (P＜0.05).There was a positive correlation between the serum levels of IL-21 and CCL20 in the model group (r=0.59, P＜0.05).Conclusions The expression of IL-21 and CCL20 in the mouse model of atopic dermatitis is increased and positively correlated, which may be synergistically involved in the occurrence and development of atopic dermatitis.

Key words： Atopic dermatitis Interleukin-21 CC chemokine ligand 20 Mouse model

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	Articles by authors
	WANG Juan
	ZHENG Ai-yi
	BAO Hai-ping
	ZHAO Yi-jin

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WANG Juan,ZHENG Ai-yi,BAO Hai-ping, et al. Expression and analysis of interleukin-21 and CC chemokine ligand 20 in atopic dermatitis mouse model[J]. 中国当代医药, 2020, 27(23): 14-16.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I23/14

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