冠心病的影响因素分析

Abstract
Figure/Table
References (19)
Related Citation (15)

Download: PDF (0 KB) HTML (36 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the influence factors of coronary artery disease (CAD).Methods A total of 1068 consecutive patients were enrolled in the Shihezi Municipal People Hospital from August 2017 and December 2019.According to the angiography results, they were divided into CAD group (651 cases) and non-CAD group (417 cases).The biochemical characteristics and ABO blood types were analyzed, multipal factors were analyzed by Logistic regression analysis.Results Univariate analysis showed that compared with the non-CAD group, the male, age, smoking, hypertension, diabetes, and body mass index levels of the CAD group were higher than those of the non-CAD group, the HDL cholesterol level was lower than that of the non-CAD group, the differences were statistically significant (P＜0.05);the differences in the prevalence of coronary heart disease between different blood types were statistically significant(P＜0.05), of which the prevalence of coronary heart disease in blood type A was higher than other blood types, the difference was statistically significant(P＜0.05);the total cholesterol, triacylglycerol and low-density lipoprotein cholesterol between the two groups were not statistically significant (P ＞0.05).Multivariate binary Logistic regression analysis showed that, blood type A (β=0.20, OR=1.22, 95%CI=1.08-1.36), male (β=0.70, OR=2.02, 95%CI=1.31-2.73), age(β=0.39, OR=1.48, 95%CI=1.14-1.82), smoking (β=0.75, OR=2.11, 95%CI=1.68-2.54), diabetes (β=1.30,OR=3.66,95%CI= 2.38-4.94), body mass index (β=0.03, OR=1.03, 95%CI=1.01-1.05) were the risk factors for coronary heart disease(P＜0.05), high-density lipoprotein cholesterol (β=-0.31, OR=0.73, 95%CI=0.54-0.92) was a protective factor for coronary heart disease(P＜0.05).Conclusions The present study indicates that the blood type A,male, age, smoking, diabetes,body mass index may be risk factors for CAD, HDL-C may be a protective factor for CAD.

Key words： Coronary artery disease Risk factor Protective factor ABO blood types

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WANG Hui
	XU Xin-yu▲

Cite this article:

WANG Hui,XU Xin-yu▲. Analysis of influencing factors on coronary artery disease[J]. 中国当代医药, 2020, 27(23): 68-71.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I23/68

[1]	国家卫生计生委合理用药专家委员会，中国药师协会.冠心病合理用药指南（第2版）[J].中国医学前沿杂志，2018，10（6）：4.
[2]	Garrison RJ，Havlik RJ，Harris RB，et al.ABO blood group and cardiovascular disease：the Framingham study[J].Atherosclerosis，1976，25（2-3）：311-318.
[3]	Whincup PH，Cook DG，Phillips AN，et al.ABO blood group and ischaemic heart disease in British men[J].BMJ，1990，300（6741）：1679-1682.
[4]	Deloukas P，Kanoni S，Willenborg C，et al.Large-scale association analysis identifies new risk loci for coronary artery disease[J].Nat Genet，2013，45（1）：25-33.
[5]	Silbernagel G，Chapman MJ，Genser B，et al.High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO：evidence from the LURIC and YFS cohorts and from a meta-analysis[J].J Am Coll Cardiol，2013，62（4）：291-299.
[6]	Wu O，Bayoumi N，Vickers MA，et al.ABO（H）blood groups and vascular disease：a systematic review and meta-analysis[J].J Thromb Haemost，2008，6（1）：62-69.
[7]	Kaya A，Tanboga IH，Kurt M，et al.Relation of ABO blood groups to coronary lesion complexity in patients with stable coronary artery disease[J].Anadolu Kardiyol Derg，2014，14（1）：55-60.
[8]	Karabuva S，Carevic V，Radic M，et al.The association of ABO blood groups with extent of coronary atherosclerosis in Croatian patients suffering from chronic coronary artery disease[J].Biochem Med （Zagreb），2013，23（3）：351-359.
[9]	第一届全国内科学术会议心血管病组，陶寿淇.关于冠状动脉性心脏病命名及诊断标准的建议[J].中华心血管病杂志，1981，9（1）：75-76.
[10]	Gong P，Luo SH，Li XL，et al.Relation of ABO blood groups to the severity of coronary atherosclerosis：an Gensini score assessment[J].Atherosclerosis，2014，237（2）：748-753.
[11]	彭敏飞，余素飞，王静，等.ABO型血与8种恶性肿瘤发生的危险度关系研究[J].中国卫生检验杂志，2014，24（6）：811-813.
[12]	Eastlund T.The histo-blood group ABO system and tissue transplantation[J].Transfusion，1998，38（10）：975-988.
[13]	Carpeggiani C，Coceani M，Landi P，et al.ABO blood group alleles：a risk factor for coronary artery disease.An angiographic study[J].Atherosclerosis，2010，211（2）：461-466.
[14]	Erikssen J，Thaulow E，Stormorken H，et al.ABO blood groups and coronary heart disease（CHD）.A study in subjects with severe and latentCHD[J].Thromb Haemost，1980，43（2）：137-140.
[15]	Anvari MS，Boroumand MA，Shoar S，et al.Ascending aorta aneurysm and blood group A among Iranian patients[J].Thromb Res，2013，131（2）：e51-53.
[16]	Ohira T，Cushman M，Tsai MY，et al.ABO blood group，other risk factors and incidence of venous thromboembolism：the Longitudinal Investigation of Thromboembolism Etiology （LITE）[J].J Thromb Haemost，2007，5（7）：1455-1461.
[17]	Hajizadeh R，Kavandi H，Nadiri M，et al.Association of ABO blood group with incidence and outcome of acute pulmonary embolism[J].Turk Kardiyol Dern Ars，2016，44（5）：397-403.
[18]	Zhou B，Wu N，Zhu C，et al.ABO blood group is a risk factor for coronary artery disease in patients with poor blood pressure control[J].Clin Exp Hypertens，2017，39（4）：366-370.
[19]	Lee HF，Lin YC，Lin CP，et al.Association of blood group A with coronary artery disease in young adults in Taiwan[J].Intern Med，2012，51（14）：1815-1820.