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Quick Search     Adv Search 2021 Vol. 28, No. 27 Published: 2021-09-28   4 Study on the mechanism of Pulsatilliae Radix in the treatment of tuberculosis based on network pharmacology LIU Yan-xia；REN Ming-hui；DU Bao-zhong Objective To screen the active constituents of Pulsatilliae Radix based on the method of network pharmacology,to predict the potential therapeutic targets of pulmonary tuberculosis and to explore its potential mechanism.Methods Pulsatilliae Radix ingredients,corresponding targets and target genes related to the treatment of pulmonary tuberculosis were selected from the traditional Chinese medicine systems pharmacology database and analysis platform,PubChem,Pharm Mapper,Uniprot,Gene Cards,OMIM databases.Combined with the String database and Cytoscape 3.6.1 software,the active component-target network diagram and the protein-protein interaction network for Pulsatilliae Radix tuberculosis treatment were constructed.GO enrichment analysis and KEGG signal pathway enrichment analysis of Pulsatilliae Radix tuberculosis treatment targets were performed by DAVID database and Weishengxin online mapping software.Results Using oral bioavailability and drug-like parameters as criteria,the 9 herb ingredients such as Mairin,Aureusidin,β-sitosterol,isorhamnetin,Stigmasterol, etc,were screened out.It is mainly used to treat tuberculosis by regulating potential targets such as nitric oxide synthase 2,leukotriene A4 hydrolase,peroxisome proliferators activate receptors, etc,these targets may through pathways in cancer and tumor necrosis factor signaling pathway to play to the role of the treatment of pulmonary tuberculosis.Conclusion Therefore,through the network pharmacological research,it was preliminarily predicted that Stigmasterol might be the main active ingredient of Pulsatilliae Radix in the treatment of pulmonary tuberculosis by regulating the cancer signal pathway and tumor necrosis factor signaling pathway,activating the process of apoptosis,participating in the immune response, etc,so as to make Mycobacterium tuberculosis lose living environment,play the role of treating tuberculosis thereby. 2021 Vol. 28 (27): 4-9 [Abstract] ( 50 ) HTML (48 KB)  PDF  (0 KB)  ( 6 ) 10 Effect of hyperbaric oxygen combined with Ginkgo Biloba Extract on serum indexes and hearing level of patients with sudden deafness HUANG Zhen-he；WANG Xin-tao;YOU Long-gui;ZHANG Ke-hui;WANG Fu-hua Objective To investigate the clinical effect of hyperbaric oxygen combined with Ginkgo Biloba Extract in the treatment of sudden hearing loss(SHL)and its influence on hearing level.Methods A total of 88 SHL patients admitted to eople′s Hospital of Ganzhou City from October 2018 to October 2020 were selected as the research objects and divided into the control group and the observation group according to the random number table method,with 44 cases in each group.Both groups received conventional treatment,the control group was treated with Ginkgo Biloba Extract,and the observation group was treated with hyperbaric oxygen based on the basis of the control group.The serum indexes,hemorheology indexes,hearing level and adverse reactions were compared between the two groups.Results There were no statistically significant differences in serum indexes between the two groups before treatment(P>0.05).After treatment,the levels of nitric oxide(NO)and superoxide dismutase(SOD)in the two groups were higher than those before treatment,and the levels of C-reactive protein(CRP)and lipid peroxide(LPO)were lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,the levels of NO and SOD in the observation group were higher than those in the control group,the levels of CRP and LPO were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in hemorheology between the two groups(P>0.05).After treatment,plasma viscosity(PV),whole blood high shear viscosity(HSV)and low shear viscosity(LSV)of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,PV,HSV and LSV in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no statistica lly significant differences in hearing levels between the two groups before treatment(P>0.05).After treatment,the hearing threshold of high frequency region and low frequency region of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the hearing threshold in the high-frequency region and low-frequency region of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P<0.05).Conclusion The treatment of hyperbaric oxygen combined with Ginkgo Biloba Extract can improve the serum indexes,correct abnormal hemorheology,and promote the recovery of hearing level in SHL patients,which is safe and reliable. 2021 Vol. 28 (27): 10-13 [Abstract] ( 38 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 17 Preparation and pharmacokinetic study in vivo of allicin derivative S-allylcysteine sustained-release preparation LIU Xu Objective To prepare sustained-release granules of S-allylcysteine(SAC)of a kind of water-soluble allicin derivatives to improve its bioavailability in rats.Methods In this experiment,the formulation was selected from the types of excipients,the ratio of main drugs and excipients and the dosage of release regulator.The preparation method was screened from the preparation temperature,heating time and the particle size of solid dispersion.Eudragit ® RS 30D was selected as blocking agent and solvent evaporation method was used to prepare the solid dispersion.The formulation and process were optimized by orthogonal design and characterized by differential scanning calorimetry(DSC)and X-ray diffraction(XRD).Blood samples were collected at 0.1,0.5,1,2,3,4,5,6,8,10,12,24 and 48 h after oral administration(35 mg/kg).The plasma concentration of SAC was determined by high performance liquid chromatography(HPLC)and the pharmacokinetic parameters were calculated.Results Eudragit ® RS 30D was used as carrier,SAC to carrier mass ratio of 1∶8,using solvent evaporation at 60℃heating for 24 h,the prepared SAC solid dispersion has good sustained release effect and good stability(RSD was 3.1%).XRD showed that no new peak appeared and phase characterization showed that SAC was highly dispersed in the carrier in amorphous or molecular state.The Cmax and Tmax of SAC solid dispersion were(5.46±1.31)μg/ml and(5.23±1.18)h and the relative bioavailability was 140.42%.Conclusion The method screened out in this study can be used for the preparation of water-soluble drug sustained-release preparations.SAC solid dispersions can significantly improve the bioavailability of SAC and prolong the effective time of drugs. 2021 Vol. 28 (27): 17-18 [Abstract] ( 45 ) HTML (48 KB)  PDF  (0 KB)  ( 6 ) 19 The role of cell apoptosis induced by endoplasmic reticulum stress in mice with deep vein thrombosis TANG Mao-shun；HU Yuan-lang；YANG Peng；LI Jian-ping；LIN Chao-qun；ZHENG Yi Objective To explore the role of cell apoptosis induced by endoplasmic reticulum stress(ERS)in mice with deep vein thrombosis(DVT).Methods Thirty-two mice were randomly divided into the normal group(10 mice),the sham operated group(11 mice)and the model group(11 mice).The model group used the method of inferior vena cava stenosis to construct the DVT model of mice.The sham operated group only exposed the vein through laparotomy without ligation.Fluorescence intensity of glucose regulated protein 78(GRP78)was detected by immunofluorescence technique.The expression of GRP78,X-box binding protein 1(XBP1),CCAAT-enhancer-binding protein homologous protein(CHOP)mRNA was detected by Realtime PCR.The expression p53 up-regulated modulator of apoptosis(PUMA),cytochrome C(Cyt C)and cysteinyl aspartate specific proteinase-3(cleaved caspase-3)was detected by western blot.Results Fluorescence intensity of GRP78 and GRP78,XBP1,CHOP mRNA expression volume of the model group were higher than those of the normal group and the sham operated group,the differences were statistically significant(P<0.05).PUMA,Cyt C and cleaved-caspase 3 protein expression levels of the model group were higher than those of the normal group and the sham operated group,the differences were statistically significant(P<0.05).Conclusion These results suggested ERS might be an important cause of apoptosis in DVT mice. 2021 Vol. 28 (27): 19-22 [Abstract] ( 45 ) HTML (39 KB)  PDF  (0 KB)  ( 8 ) 23 Predictive value of serum Resistin and Irisin in postpartum blood glucose outcome of gestational diabetes mellitus BAI Xue；ZHONG Hai-hua；WANG Xiao-jie；CHEN Pan Objective To explore the expression of Resistin and Irisin in serum of patients with gestational diabetes mellitus(GDM)and the value of predicting the outcome of postpartum blood glucose in patients with GDM.Methods A total of 183 patients with GDM who were examined and hospitalized for delivery in the Affiliated Hospital of Southwest Medical University from January 2019 to June 2020 were selected.They were divided into good outcome group(103 cases)and bad outcome group(80 cases)according to their blood glucose outcomes at 8 weeks after delivery.Enzyme linked immunosorbent assay was used to detect serum Resistin and Irisin levels,and multi-factor logistic regression was used to analyze the influencing factors of poor postpartum blood glucose outcome in GDM patients.ROC curve was plotted to analyze the diagnostic value of serum Resistin and Irisin expression in poor postpartum blood glucose outcome in GDM patients.Results The pre-pregnancy body mass index,gestational age of diabetes diagnosis,triglyceride(TG),total cholesterol(TC),and insulin usage of GDM patients in the good outcome group were compared with those in the poor outcome group,the differences were statistically significant(P<0.05).Serum Resistin level in GDM patients with poor outcome was higher than that in good outcome group,and the expression level of Irisin was lower than that in good outcome group(P<0.05).Multivariate logistic regression analysis showed that gestational age,TC,Resistin and Irisin were independent influencing factors of poor postpartum blood glucose outcome in GDM patients(P<0.05).The sensitivity,specificity and area under the curve of serum Resistin and Irisin combined in predicting poor postpartum blood glucose outcome in GDM patients were 86.25%,88.35%,and 0.924.Conclusion The combined detection of Resistin and Irisin in serum of GDM patients has high diagnostic value for poor postpartum blood glucose outcome in GDM patients,and may be used as a potential marker for predicting poor postpartum blood glucose outcome in GDM patients. 2021 Vol. 28 (27): 23-26 [Abstract] ( 41 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 27 Clinical effect of ultrasound-guided vacuum minimally invasive atherectomy in the treatment of benign breast tumors YU Yong；ZHOU Ge Objective To explore the clinical effect of ultrasound-guided vacuum minimally invasive atherectomy in the treatment of benign breast tumors.Methods The clinical data of 100 patients with benign breast tumors admitted to Liaoyang Central Hospital from November 2019 to October 2020 were retrospectively analyzed,and they were divided into study group(50 cases)and control group(50 cases)according to the different surgical methods.The study group underwent ultrasound-guided minimally invasive breast resection,while the control group underwent conventional open mastectomy for benign breast neoplasm.The operation time,hospitalization time,intraoperative blood loss,length of incision,patient satisfaction and the overall incidence of postoperative complications between the two groups were compared.Results The duration of operation,length of hospital stay and length of incision of the study group were shorter than those of the control group,the intraoperative blood loss of study group was less than that in the control group,the differences were statistically significant(P<0.05).The satisfaction of treatment effect in the study group was higher than that in the control group,and the total incidence of complications in the study group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion For the resection of benign breast tumors,ultrasound-guided minimally invasive breast resection can shorten the length of surgery,the length of hospital stay,the length of incision,and reduce intraoperative blood loss,improve patient satisfaction and reduce the overall incidence of complications.It has significant clinical application value and is worth popularizing in clinical practice. 2021 Vol. 28 (27): 27-30 [Abstract] ( 42 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 31 Application progress of home nursing in chronic wound management and its implications HUO Xue-qin；WU Qiong；ZHANG Ai-ping；YI Yu-mei The contradiction between the aging population and the scarce public medical resources leads to the implementation of the concept and model of home nursing service.Home nursing can allow patients with care needs to receive professional nursing services in a familiar environment,so that patients to achieve the purpose of disease prevention and health promotion.At present,home nursing service has been gradually applied and popularized in patients with chronic wounds.In this paper,the qualification requirements,service modes and application effects of home nursing service in the daily management of chronic wound patients at home and abroad were reviewed,and relevant suggestions were put forward based on the current situation and problems of home nursing in China. 2021 Vol. 28 (27): 31-34 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 35 Research progress on brain protection of anesthetics LI Cui；MU Rui；YU Jian-bo The brain is the highest regulating organ of the body,and it controls all the activities of the body.Brain diseases often lead to varying degrees of sensory,motor,language,emotion,and cognitive dysfunction,and even longterm functional limitation in patients,and cerebrovascular disease is one of the three leading causes of human death.How to choose suitable anesthetics to protect brain function for surgical patients with brain diseases has received increasing clinical attention.In this paper,the recent studies on the cerebral protective effects of common anesthetics were reviewed,and the characteristics and mechanism of cerebral protective effect of anesthetics were explored to provide reference for the selection of anesthetics for patients with brain diseases.The cerebral protective effects of anesthetics require further basic and clinical studies. 2021 Vol. 28 (27): 35-38 [Abstract] ( 48 ) HTML (40 KB)  PDF  (0 KB)  ( 6 ) 39 Research progress in functional and clinical applications of human umbilical cord mesenchymal stem cells ZHANG Xue-juan;SUN Xu-yan;YANG Wei-juan;ZHANG Xiu-tao；GAO Zong-sheng；SUN Hong-tao Human umbilical cord mesenchymal stem cells(hUC-MSCs)as a kind of stem cells with great development potential,are easy to collect and do not involve ethics.hUC-MSCs can be collected from the perivascular tissues,arteries and veins of the umbilical cord and the part of Wharton jelly.Its proliferation and differentiation characteristics are remarkable,and it can promote tissue repair and immune regulation.The quantity and quality of hUC-MSCs from different individuals were different.hUC-MSCs have been applied more and more widely in the field of cell therapy,and have achieved remarkable clinical effects in the fields of organ injury disease,nervous system disease,endocrine system disease and so on.This paper reviews the research progress in the function,safety and clinical application of umbilical cord mesenchymal stem cells,summarizes their therapeutic value and the problems faced in the research process,in order to explore more application potential of hUC-MSCs. 2021 Vol. 28 (27): 39-43 [Abstract] ( 37 ) HTML (50 KB)  PDF  (0 KB)  ( 6 ) 44 Research progress of preoperative visit mode at home and abroad HUANG Chao-yi;HE Lu;ZENG Yang-fan;CHEN Shan In order to explore a new model of preoperative visit in China,understand the research status of preoperative visit at home and abroad，the visit needs of surgical patients,and provide a new and effective visit model for patients.PubMed was searched with "preoperative visit" as the subject term,and a total of 3118 literatures were retrieved.A total of 3311 literatures were retrieved from CNKI using "preoperative visit" as the subject search term.The two researchers selected 256 literatures related to the research topic by reading the title and abstract respectively,and then downloaded and read the full text and selected 30 literatures related to the mode of preoperative visit.The results showed that foreign preoperative visit paid more attention to the holistic nursing intervention combining preoperative education and postoperative rehabilitation.Nursing staff in China are exploring a variety of visit modes,among which the multi-media-assisted preoperative visit is still in the stage of exploration and development.How to rationally use new media information resources and provide efficient tools for preoperative visit staff still needs further study. 2021 Vol. 28 (27): 44-47 [Abstract] ( 42 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 48 Application of coordinate axis in improving the positioning accuracy of PICC chest radiographs for intravenous nurses OUYANG Hua；OUYANG Yuan； ZHU Hong-yan； LIAO Ting； JIA Ting； YAO Li； JIANG Fa-liang ；WANG Ping Objective To explore the application of chest radiograph coordinate axis positioning method in peripherally inserted central catheter(PICC).Methods A total of 60 patients who received PICC catheterization in the Pingxiang Second People′s Hospital from December 2019 to December 2020 were selected.They were divided into the control group(30 patients)and the observation group(30 patients)using random number table method.The control group were given chest radiograph thoracic spine positioning method,and the observation group were given the chest radiograph coordinate axis positioning method to place the catheter.The accuracy of catheter tip,incidence of complications,and catheterization satisfaction were compared between the two groups.Results The accuracy rate of catheter tip in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).The degree of catheterization satisfaction in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).Conclusion Chest radiograph coordinate axis positioning can increase the accuracy of catheter tip,reduce the incidence of complications,and improve satisfaction in patients with PICC catheterization.It is worthy of clinical promotion and application. 2021 Vol. 28 (27): 48-50 [Abstract] ( 51 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 51 Study on the relationship between intestinal mucosal permeability and the classification and prognosis of patients with liver cirrhosis ZHANG Yi；HUANG Mao-hui；CHEN Li-jun；LEI Qing；ZHUGE Qun Objective To study the relationship between the changes in intestinal mucosal permeability and the classification and prognosis of patients with liver cirrhosis.Methods A total of 60 patients with liver cirrhosis admitted to Shangrao City People′s Hospital from September 2019 to October 2020 were selected as the research objects and divided into cirrhosis group,and they were divided into group A(25 cases),group B(29 cases)and group C(6 cases)by Child-Pugh score.Another 60 cases of normal physical examination in Shangrao People′s Hospital during the same period were selected as health group.The intestinal mucosal permeability indexes of the subjects in the cirrhosis group and the healthy group were compared,and the prognosis of the patients in the cirrhosis group were compared.Results The levels of serum diamine oxidase(DAO),D-lactic acid,and endotoxin(EXT)in the cirrhosis group were higher than those in the healthy group,and the differences were statistically significant(P<0.05).The serum levels of DAO,D-lactic acid ,EXT and model for end-stage liver disease(MELD)score in group C were higher than those of group A and group B,and the differences were statistically significant(P<0.05).The levels of serum DAO,D-lactic acid ,EXT and MELD in group B were higher than those of group A,and the differences were statistically significant(P<0.05).D-lactic acid,EXT and MELD were all positively correlated with MELD(P<0.05).Conclusion Changes in intestinal mucosal permeability are positively correlated with the classification and prognosis of patients with liver cirrhosis.Clinically,detection of serum DAO,D-lactic acid and EXT levels in patients with liver cirrhosis can be considered to guide early risk assessment and prevention. 2021 Vol. 28 (27): 51-53 [Abstract] ( 49 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 54 Design and clinical application of inserting vaginal surgical instruments platform LONG Jie；ZHOU Zeng；HU Zhu；HUANG Lan；ZHANG Lian-ying；WU Xue-lian Objective To investigate the design and clinical application of the platform of inserting vaginal surgical instruments.Methods A total of 40 obstetrics and gynecology patients admitted to Ganzhou Maternal and Child Health Hospital from October 2019 to October 2020 were selected as the research subjects.According to the random number table method,they were divided into the control group(20 cases)and the observation group(20 cases).The control group was not performed on the inserting vaginal surgical instruments platform,while the observation group was performed on the inserting vaginal surgical instruments platform.The contamination rate,operating time,intraoperative blood loss and comfort level of patients using the instrument platform were compared between the two groups.Results The contamination rate of the observation group was lower than that of the control group,the operating time was shorter than that of the control group,the intraoperative blood loss was less than that of the control group,and the comfort level of patients using the instrument platform was higher than that of the control group,the differences were statistically significant(P<0.05).Conclusion The design of the inserting vaginal surgical instruments platform has the advantages of easy sampling and low cost.The application in clinical practice can reduce the contamination rate,shorten the operating time,reduce the amount of intraoperative blood loss,and improve the comfort level of patients using the instrument platform. 2021 Vol. 28 (27): 54-57 [Abstract] ( 47 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 58 Application effect of Compound Pancreatin Tablets in elderly patients with nasal feeding in Neurology Department LI Fen；ZHU Xue-peng；Xu Juan；Xiong Yan Objective To analyze the application effect of Compound Pancreatin Tablet in elderly patients with nasal feeding in Neurology Department.Methods A total of 94 elderly patients with nasal feeding received from the Department of Neurology of Yichun People′s Hospital from October 2019 to February 2021 were selected,and they were divided into the control group(47 cases)and the study group(47 cases)by a random number table methods.The control group was given routine nasal feeding,and the study group was added with Compound Pancreatin Tablets on the basis of the control group.The incidence status of complications such as gastric retention,abdominal distention,aspiration,diarrhea,gastric tube obstruction,treatment efficiency and nutritional status of the two groups were observed.Results The total incidence rate of complication in the study group was 10.64%,which was lower than 27.66% in the control group,with statistically significant difference(P<0.05).The total effectiveness rate in the study group was 97.87%,which was higher than 82.98% in the control group,with statistically significant difference(P<0.05).There were no significant differences in the levels of serum total protein(TP),hemoglobin(HGB)and prealbumin(PA)between the two groups before treatment(P>0.05).After treatment,the levels of TP,HGB,and PA in the study group were higher than those in the control group,with statistically significant difference(P<0.05).The levels of TP,HGB,and PA in the two groups after treatment were higher than those before treatment,with statistically significant difference(P<0.05).Conclusion The use of Compound Pancreatin Tablets in elderly patients with nasal feeding in the Department of Neurology can effectively reduce the risk of complications of indwelling gastric tube and improve their nutritional status. 2021 Vol. 28 (27): 58-60-64 [Abstract] ( 61 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 61 Correlation analysis of serum homocysteine,uric acid levels and severity degree of coronary artery disease in patients with coronary heart disease and diabetes mellitus GU Shang-wu；FENG Hong；CHEN Yao；ZENG Di；HE Xiao-li；ZHANG Xing-wei Objective To explore the changes of serum homocysteine(Hcy)and uric acid levels in patients with coronary heart disease and diabetes mellitus,and their correlation with the severity of coronary artery disease.Methods A total of 137 patients with coronary heart disease and diabetes mellitus who were enrolled in the Department of Cardiovascular Medicine of People′s Hospital of Bozhou District in Zunyi City from June 2018 to October 2020 were included in the observation group.The observation group was divided into the low risk group(n=42),the medium-sange group(n=59),the high-risk group(n=36).30 patients with diabetic mellitus in the same period were selected as the control group.The levels of serum Hcy and uric acid in the control group and the observation group were compared,and the levels of serum Hcy and uric acid in the low-risk group,the medium-risk group and the high-risk group were recorded.Pearson correlation analysis was used to analyze the correlation between serum Hcy,uric acid and Gensini score.Results The levels of serum Hcy and uric acid in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).There were significant difference in the levels of Hcy and uric acid among the three groups(P<0.05).There was no significant difference in the level of Hcy between the low-risk group and the middle-risk group(P>0.05).The Hcy level of the high-risk group was higher than that of the low-risk group and the middle-risk group,the uric acid level of the middle-risk group and high-risk group were higher than that of the low-risk group,the uric acid level of the high-risk group was higher than that of the middle-risk group,the differences were statistically significant(P<0.05).Serum Hcy and uric acid were positively correlated with Gensini score(r=0.786,0.429, P<0.001).Conclusion The levels of serum Hcy and uric acid in patients with coronary heart disease and diabetes mellitus increase,and the levels of serum Hcy and uric acid are positively correlated with the degree of coronary artery disease. 2021 Vol. 28 (27): 61-64 [Abstract] ( 44 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 65 Clinical application of bedside bronchoscopy sputum suction and alveolar lavage in the treatment of patients with acute massive cerebral infarction and stroke associated pneumonia DENG Zhi-qiang；GONG Shi-gao；LI Cheng-zhi；CHEN Rui-juan；WU Sheng-ge；LI Pu；MAI Hui-ting；XIANG Qun-li Objective To investigate the clinical application of bedside bronchoscopy sputum suction and alveolar lavage in the treatment of patients with acute massive cerebral infarction and stroke associated pneumonia.Methods A total of 100 patients with acute massive cerebral infarction hospitalized in neurology department of Guangdong Tongjiang hospital from January 2020 to December 2020 were selected as the research objects.They were divided into control group and treatment group according to the block grouping method,with 50 cases in each group.The control group was treated with routine treatment,nutritional support,professional nursing and routine antibiotics.On the basis of the treatment of the control group,bedside bronchoscopy was established as soon as possible after the diagnosis of stroke-associated pneumonia,and bronchoscopic sputum aspiration combined with alveolar lavage was adopted in the treatment group.The changes of white blood cell count(WBC),C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT),oxygenation index,length of hospital stay and rate of endotracheal intubation were compared between the two groups.Results After one week of treatment,the WBC,CRP,IL-6 and PCT of the treatment group were lower than those of the control group,and the oxygenation index was higher than that of the control group,the differences were statistically significant(P<0.05).The length of hospitalization in the treatment group was shorter than that of the control group,and the rate of endotracheal intubation was lower than that of the control group,the differences were statistically significant(P<0.05).Conclusion The clinical application of bedside bronchoscopy sputum suction and alveolar lavage in the treatment of patients with acute massive cerebral infarction and stroke associated pneumonia can control infection early,improve arterial blood gas index and inflammatory index,shorten hospitalization time and reduce the rate of tracheal intubation. 2021 Vol. 28 (27): 65-68 [Abstract] ( 45 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 69 Clinical effect of Losartan on maintenance hemodialysis and its effect on iron metabolism and inflammatory factors ZHANG Wen-bin；CHI Xiang-geng；CHEN Yan-zhuan；XUAN Xing-hua；CAI Qi Objective To explore the clinical efficacy of Losartan in the treatment of maintenance hemodialysis(MHD)patients with chronic kidney disease(CKD)and its effect on iron metabolism and inflammatory factors.Methods A total of 50 patients with CKD who received maintenance hemodialysis in Xiaolan people′s Hospital of Zhongshan City from June 2019 to June 2020 were selected as the research objects.They were randomly divided into the treatment group and the control group,with 25 cases in each group.The treatment group was treated with Losartan,while the control group was treated with conventional renal anemia The changes of C-reactive protein(CRP),interleukin-6(IL-6),ferritin(SF)and transferin saturation(TSAT)were observed.Results After 3 months of treatment,the total clinical effective rate of the treatment group was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no significant differences in CRP,IL-6,TSAT and SF between the two groups before treatment and one month after treatment(P>0.05).After 2 and 3 months of treatment,CRP,IL-6 and SF in the treatment group were lower than those in the control group,and TSAT was higher than that in the control group,with statistical significances(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Losartan in the treatment of maintenance hemodialysis patients with CKD can effectively improve the symptoms of anemia,relieve the micro inflammatory state,and has high safety. 2021 Vol. 28 (27): 69-72 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 73 Application effect of application of double-tube laryngeal mask in prehospital first aid for patients with deep coma HUANG Lei-ming；SHU Min；LI Zhuo；ZHU Jing Objective To explore the effectiveness of application of dual-tube laryngeal mask in pre-hospital first aid for patients with deep coma.Methods A total of 90 patients with deep coma who were treated in Huazhong University of Science and Technology Union Shenzhen Hospital from October 2019 to October 2020 were selected as the objects of this research and divided into the control group(30 cases),the contrast group(30 cases)and the study group(30 cases)according to the number grouping method.The control group was treated with air tube intubation method;the contrast group was treated with oropharyngeal ventilation tube method,and the study group was treated with double-tube laryngeal mask method.The effectiveness of pre-hospital first-aid,blood gas indexes(SaO2),arterial oxygen partial pressure(PaO2),partial pressure of carbon dioxide in artery(PaCO2)and lactic acid(LAC)before and 30 min after catheterization and complications during intubation were compared among the three groups.Results There was no significant difference in the first-aid effect between the study group and the control group(P>0.05),but the first-aid effect of the study group was better than that of the contrast group(P<0.05).SaO2 and PaO2 in the three groups 30 min after catheterization were higher than before catheterization,PaCO2 and LAC were lower than those before catheterization,the differences were statistically significant(P<0.05).The total incidence of complications during intubation in the study group was lower than that in the control group and the contrast group,the difference was statistically significant(P<0.05).Conclusion In the pre-hospital first aid of patients with deep coma,the improvement of hypoxemia by double-tube laryngeal mask is close to that by endotracheal intubation.However,in contrast,the double-tube laryngeal mask shows its superiority in the optimal timeliness,which can not only effectively improve the blood gas analysis index of patients,but also has high safety.Therefore,double-tube laryngeal mask has ideal application value in pre-hospital first aid for patients with deep coma. 2021 Vol. 28 (27): 73-75-79 [Abstract] ( 48 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 76 Clinical effect of bronchoscope combined with non-invasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure ZHANG Nan Objective To investigate the clinical effect of patients with chronic obstructive pulmonary disease(COPD)and respiratory failure receiving bronchoscopy combined with non-invasive positive pressure ventilation(NPPV).Methods A total of 74 patients with COPD and respiratory failure admitted to the Iron Coal General Hospital of Liaojian Group from July 2018 to November 2020 were selected as the research objects,and they were divided into the control group(37 cases)and the observation group(37 cases)according to a random number table methods.The control group was treated with NPPV,and the observation group was treated with bronchoscope on the basis of the control group.The arterial blood gas indexes(arterial partial pressure of carbon dioxide[PaCO2],arterial partial pressure of oxygen[PaO2],pH),lung function(total lung capacity[TLC],forced expiratory volume in one second[FEV1]/forced vital capacity[FVC],FVC)of the two groups were compared.Results There was no significant difference in the levels of PaCO2,PaO2,pH,TLC,FEV1/FVC,FVC between the two groups before treatment(P＞0.05).The level of PaCO2 of the observation group after 2 weeks of treatment was lower than that of the control group,and the levels of PaO2,pH,TLC,FEV1/FVC,FVC of the observation group after 2 weeks of treatment were all higher than those of the control group,the differences were statistically significant(P＜0.05).Conclusion Bronchoscope and NPPV in the treatment of patients with COPD and respiratory failure can enhance the efficacy,and improve the blood gas indicators and lung function of patients as soon as possible.It is worthy of promotion. 2021 Vol. 28 (27): 76-79 [Abstract] ( 46 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 80 Effect of ultrasound-guided selective nerve block in perineal area during resection of vestibular glandular resection CHEN Juan；HUANG Yuan；WU Qing；XU Yu；LIU Yong-xian Objective To observe the effect of selective nerve block guided by ultrasound in perineum during vestibular glandular resection.Methods A total of 84 patients with vestibular great gland cyst admitted to the Department of Obstetrics and Gynecology of Changsha Central Hospital from March 2019 to March 2021 were selected as the research subjects,and they were divided into observation group(42 cases)and control group(42 cases)by random number table method.The observation group received perineal ultrasound-guided selective nerve block,and the control group received spinal anesthesia.Hemodynamic indexes,perioperative visual analog scale(VAS)score,total incidence of postoperative complications and postoperative recovery time were compared between the two groups before and after anesthesia.Results Before anesthesia,there were no significant differences in systolic blood pressure,diastolic blood pressure,heart rate and VAS score between two groups(P>0.05).30 min after anesthesia,systolic blood pressure,diastolic blood pressure and heart rate of patients in both groups were lower than before anesthesia,the differences were statistically significant(P<0.05).60 min after anesthesia,systolic blood pressure,diastolic blood pressure and heart rate in two groups were higher than those before and 30 min after anesthesia,the differences were statistically significant(P<0.05).The systolic blood pressure,diastolic blood pressure and heart rate of the observation group were lower than those of the control group 30 and 60 min after anesthesia,the differences were statistically significant(P<0.05).At 12 h after anesthesia,VAS scores in both groups were lower than those before anesthesia,the differences were statistically significant(P<0.05).24 h after anesthesia,VAS scores of the two groups were higher than those before and 12 h after anesthesia,the differences were statistically significant(P<0.05).The VAS score of the observation group at 12 and 24 h after anesthesia was lower than that of the control group,the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was 16.67%,lower than 45.2% in the control group,and the difference was statistically significant(P<0.05).The postoperative recovery time of observation group was shorter than that of control group,and the difference was statistically significant(P<0.05).Conclusion Patients with perineal ultrasound-guided selective nerve block during vestibular gland resection have relatively stable hemodynamics,accurate effect and better analgesic effect.Meanwhile,it can reduce surgical complications and shorten postoperative recovery time,which is conducive to the recovery of patients,and is worthy of widespread clinical application. 2021 Vol. 28 (27): 80-83 [Abstract] ( 38 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 84 Application effect of double purse-string bridging pancreaticojejunostomy gastrointestinal reconstruction in pancreaticoduodenectomy ZHAO Xin-hua；’XIONG Ri-hui；RUAN Li-qin Objective To investigate the application effect of double purse-string bridging pancreaticojejunostomy gastrointestinal reconstruction in pancreaticoduodenectomy.Methods A total of 120 patients who underwent laparoscopic pancreaticoduodenectomy in the First People′s Hospital of Jiujiang City were selected as the research objects.They were divided into the study group and the control group by simple randomization,with 60 cases in each group.Both groups of patients underwent laparoscopic pancreaticoduodenectomy.The study group used double purse-string bridging pancreaticojejunostomy,and the control group used traditional pancreaticojejunostomy.The operation time,pancreaticojejunostomy time,interoperative bleeding volume and rate of postoperative complications were compared between the two groups of patients.Results The operation time and the pancreaticojejunostomy time of the study group([5.5±0.3]h,(25.3±7.1)min)were shorter than those of the control group([6.1±0.5]h,[35.8±8.0]min),and the differences were statistically significant(P<0.05).The interoperative bleeding volume of the study group([342.7±34.6]ml)was less than that of the control group([370.0±27.2]ml),and the difference was statistically significant(P<0.05).The total incidence of postoperative complications in the study group(5.0%)was lower than that in the control group(26.7%),and the difference was statistically significant(P<0.05).Conclusion Double purse-string bridging pancreaticojejunostomy gastrointestinal reconstruction obtains a good application effect in pancreaticoduodenectomy.It is a safe and effective for pancreaticojejunostomy and can be promoted in clinical practice. 2021 Vol. 28 (27): 84-86 [Abstract] ( 53 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 87 Clinical effect of modified localization of lower limb mechanical force lines in open wedge high tibial osteotomy YANG Yi-bin；CHEN Xia-guang；LIU Tao Objective To investigate the clinical effect of open wedge high tibial osteotomy(OWHTO)for positioning the lower limb mechanical force line.Methods A total of 104 patients with medial compartment osteoarthritis of knee joint admitted to Ganzhou People′s Hospital from March 2019 to December 2019 were selected and divided into control group and observation group by random number table method,52 cases in each group.Both groups were treated with OWHTO,lower extremity mechanical line localization was performed by traditional method in the control group,and improved method was used in the observation group.The surgical indicators,knee and ankle angle(HKA)and osteoarthritis index(WOMAC)were compared between the two groups.Results Comparison of intraoperative blood loss between the two groups,the difference was not statistically significant(P>0.05).The operation time of the observation group was shorter than that of the control group ,and the number of intraoperative fluoroscopy was less than that of the control group ,the differences were statistically significant(P<0.05).Comparison of HKA angle and WOMAC scores between the two groups before and one year after surgery,the difference was not statistically significant(P>0.05);the HKA angle of the two groups was greater than that of the preoperative one year after surgery,and the WOMAC score was higher than that of the preoperative group,the differences were statistically significant(P<0.05).Conclusion The improved method of positioning the mechanical force line of lower extremity is effective in OWHTO operation,which can shorten the operation time,avoid repeated fluoroscopy and reduce the radiation exposure of the operator and the patient. 2021 Vol. 28 (27): 87-89-93 [Abstract] ( 35 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 90 Analysis of the effect of Somatostatin on improving the prognosis of patients after laparoscopic gastrointestinal perforation repair YOU Bo；WU Chang-hua；ZOU Guo-qiao；YU Jian；JIANG Xiao-xue Objective To study the effect of Somatostatin on improving the prognosis of patients after laparoscopic gastrointestinal perforation repair.Methods A total of 77 cases of patients undergoing laparoscopic gastrointestinal perforation repair were selected from the Department of Emergency Surgery,Fuzhou First People′s Hospital from November 2019 to January 2021,according to random number table method to divide into control group(39 cases)and treatment group(38 cases).Both groups of patients underwent laparoscopic gastrointestinal perforation repair.Postoperative,patients in the control group were given routine postoperative treatment such as fluid rehydration and anti-inflammatory,the treatment group was given Somatostatin.The postoperative recovery,hospital stay,hospital costs and postoperative inflammatory cytokine levels and the incidence of complications were compared between the two groups.Results Postoperative bowel function recovery time,first normal eating time,gastrointestinal decompression and drainage time,first bowel movement time,first time out of bed,the drainage tube indwelling time and hospital stay in treatment group were shorter than those in the control group,the differences were statistically significant(P<0.05).Hospitalization expenses in the treatment group was lower than that in the control group,the difference was statistically significant(P<0.05).Three days after operation,the serum tumor necrosis factor(TNF)-α,interleukin(IL)-6,and high-sensitivity C-reactive protein(hs-CRP)levels of the treatment group were lower than those in the control group,the differences were statistically significant(P<0.05).The total incidence of postoperative complications in the treatment group is lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Application of somatostatin after laparoscopic repair of gastrointestinal perforation can effectively improve postoperative recovery,reduce the level of inflammatory factors in the body,shorten hospital stay,reduce hospital costs,the overall incidence of postoperative complications and significantly reduced,better prognosis than conventional postoperative anti-inflammatory treatment. 2021 Vol. 28 (27): 90-93 [Abstract] ( 41 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 94 Clinical effect of arthroscopically assisted allograft tendon anatomic reconstruction of coracoclavicular ligament in treatment of acromioclavicular joint dislocation(Rockwood type Ⅲ-Ⅴ) XIONG Guo-an；XIE Jing-bo；XIAO Yi-bing；XIONG Jun-wei；DING Chao Objective To explore the clinical effect of arthroscopically assisted allograft tendon anatomic reconstruction of coracoclavicular ligament in the treatment of acromioclavicular joint dislocation(Rockwood type Ⅲ-Ⅴ).Methods Eighty-four patients with acromioclavicular joint dislocation treated in Fengcheng People′s Hospital from June 2018 to January 2020 were retrospectively selected as research subjects,and were divided into the routine group(n=42)and the observation group(n=42)according to the treatment.The observation group was given arthroscopically assisted allograft tendon anatomic reconstruction of coracoclavicular ligament,and the routine group was given open reduction and hook plate fixation.The upper limb function,shoulder joint function and pain degree of the two groups were compared.Results The disability of arm shoulder and hand(DASH)at 3 days and 6 weeks after treatment in the observation group were lower than those in the routine group,and the shoulder joint function scores(Constant-Murley)in the observation group were higher than those in the routine group,the differences were statistically significant(P＜0.05).The visual analogue scale(VAS)scores at 3 days and 6 weeks after treatment in the observation group were lower than those in the routine group,the differences were statistically significant(P＜0.05).There were no statistically significant differences in the DASH score,Constant-Murley score,VAS score before treatment and at 6 and 12 months after treatment between the two groups(P＞0.05).During the follow-up period,there was no fixation failure,re-dislocation or allogeneic tendon rejection in the two groups.Conclusion For patients with acromioclavicular joint dislocation,the arthroscopically assisted allograft tendon anatomic reconstruction of coracoclavicular ligament can significantly relieve the pain of patients and improve the function of the shoulder joint,which is worthy of promotion. 2021 Vol. 28 (27): 94-97 [Abstract] ( 36 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 98 Application effect of small incision fat removal combined with continuous catgut embedding double eyelid plasty in asymmetric eyelid plastic surgery DU Ji-feng Objective To explore the application effect of small incision fat removal combined with continuous catgut embedding double eyelid plasty in asymmetric eyelid plastic surgery.Methods From January 2018 to February 2020,90 patients with asymmetric double eyelids in the Department of Plastic Surgery in Xinglin Plastic Surgery Hospital were selected as the research objects and divided into the experimental group and the control group,with 45 cases in each group.The experimental group was treated with small incision fat removal,continuous catgut embedding and double eyelid plasty,while the control group was treated with conventional incision double eyelid plasty.The operation indexes,patient satisfaction and adverse reactions of the two groups were compared.Results The amount of bleeding in the experimental group was less than that in the control group,the healing time and operation time were shorter than those in the control group,the total satisfaction was higher than that in the control group,and the total incidence of adverse reactions was lower than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Double eyelid plasty with small incision fat removal combined with continuous catgut embedding method for asymmetric double eyelid has the advantages of simple operation,short operation time,less blood loss,less adverse reactions,fast recovery and high patient satisfaction,which is worthy of clinical application. 2021 Vol. 28 (27): 98-100 [Abstract] ( 42 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 101 Clinical application study of total laparoscopic thyroid tumor resection through areola incision ZHU Kai；YU Kun-lin；JIN Zhong-kui；LIU Chang-shan；LUO Cai-lu Objective To study the clinical application value of total laparoscopic thyroid tumor resection through areola incision.Methods From January 2018 to December 2020,102 patients with thyroid tumors admitted to the three general wards of the People′s Hospital of Yichun City,Jiangxi Province were selected as the research objects,and they were divided into the control group and the observation group by random number table method,with 51 cases in each group.Patients in the control group underwent open thyroidectomy,and patients in the observation group underwent full laparoscopic thyroid tumor resection through the areola incision.The basic conditions of the operation,the total incidence of complications,and the cosmetic effect of 7 days after the operation were compared between the two groups.Results The incision length of the observation group was shorter than that of the control group,the operation time was longer than that of the control group,the blood loss during operation was less than that of the control group,the postoperative drainage volume was much than that of the control group,and the hospital stay was shorter than that of the control group,the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The cosmetic effect score of the observation group was higher than that of the control group on the 7 days after operation,and the difference was statistically significant(P<0.05).Conclusion Compared with open thyroidectomy,total laparoscopic resection of thyroid tumor through areola incision can reduce the occurrence of complications and improve the cosmetic effect. 2021 Vol. 28 (27): 101-103 [Abstract] ( 39 ) HTML (31 KB)  PDF  (0 KB)  ( 9 ) 104 Clinical comparative study of endoscopic retrograde cholangiopancreatography guided by ultrasound and X-ray in the treatment of choledocholithiasis LIU Yi-bing；DAI Jing-yu；WU Ya-jing；CHEN Xia Objective To compare and study the clinical effect of endoscopic retrograde cholangiopancreatography(ERCP)with ultrasound and X-ray guidance in the treatment of choledocholithiasis.Methods A total of 60 patients with choledocholithiasis undergoing ERCP in the Central Hospital of Longgang District of Shenzhen City from January to December 2019 were enrolled as the research objects.According to simple randomization method,they were divided into the B-ERCP group and the X-ERCP group,30 cases in each group.The B-ERCP group was treated with ERCP under ultrasound guidance,and the X- ERCP group was treated with ERCP under X-ray guidance.The surgical success rate and postoperative recovery were compared between the two groups.The surgical indexes(operation time,intraoperative blood loss),intraoperative and postoperative complications in both groups were recorded.The hospitalization time and cost were compared between the two groups.Results The postoperative recovery of the B-ERCP group was better than that of the X-ERCP group,the difference was statistically significant(P＜0.05).The incidence of intraoperative complications in the B-ERCP group was higher than that in the X-ERCP group(13.33% vs.0.00%),the difference was statistically significant(P＜0.05).The incidence of postoperative complications in the B-ERCP group was lower than that in the X-ERCP group(6.67% vs 30.00%),the difference was statistically significant(P＜0.05).The operation time in the B-ERCP group was longer than that in the X-ERCP group,intraoperative blood loss in the B-ERCP group was more than that in the X-ERCP group,postoperative hospitalization time in the B-ERCP group was shorter than that in the X-ERCP group,and hospitalization cost in the B-ERCP group was less than that in the XERCP group,the differences were statistically significant(P＜0.05).There was no significant difference in the operation success rate between the two groups(P＞0.05).Conclusion There is no significant difference in the surgical success rate between ultrasound and X-ray guided ERCP for choledocholithiasis patients.Compared with X-ray guidance,ultrasound-guided surgery has longer surgery time,more blood loss,but lower incidence of postoperative complications,shorter postoperative hospital stay and lower cost,and the postoperative recovery is better than X-ray guidance. 2021 Vol. 28 (27): 104-107 [Abstract] ( 47 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 108 Clinical study on the use of TiNi encircling bone connector to prevent and treating sternal opening after cardiac surgery ZHU Shen-yu；YU Xiao-qiang；LIU Zi-you；LI Shu-lin；XIONG Jian-xian Objective To explore the clinical value of using TiNi encircling bone connector to prevent and treating sternal opening after cardiac surgery.Methods From June 2018 to October 2020,90 patients who were to undergo cardiac surgery in the Department of Cardiothoracic Surgery of the First Affiliated Hospital of Gannan Medical College were selected.The patients were divided into the study group(45 cases)and the reference group(45 cases)according to the random number table method.The reference group used steel wires to fix the sternum during the operation,and the study group used TiNi encircling bone connectors to fix the sternum during the operation.The surgery-related indicators,the occurrence of postoperative complications were compared between the two groups.Results The visual analogue scoring(VAS)score of the study group was(5.17±1.14)points,which was lower than the(7.65±1.08)points of the reference group,the difference was statistically significant(P<0.05).The postoperative ventilator use time of the study group was(18.34±4.54)h,and the intensive care ward(ICU)stay time of the study group was(43.97±7.54)h,hospitalization time of the study group was(13.67±2.04)d,which were shorter than those of the reference group([26.65±9.21],[63.50±14.65]h,[19.86±3.24]d),the differences were statistical significance(P<0.05).There was no significant difference in the operation time between the two groups(P>0.05).The total incidence of postoperative complications in the study group was lower than that in the reference group,and the difference was statistically significant(P<0.05).Conclusion The application of TiNi embracing bone connector in cardiac surgery can reduce postoperative pain,reduce the occurrence of sternal opening and lung infection,shorten the time of postoperative ventilator use,ICU stay,and hospital stay,and help patients recover quickly. 2021 Vol. 28 (27): 108-110 [Abstract] ( 33 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 111 Clinical effect of modified C-shaped tissue-selecting therapy of hemorrhoids mucosa in the treatment of hemorrhoids LI Fu-quan；XIE Wen-feng；ZHOU Yu-neng Objective To study the clinical effect of modified C-shaped tissue-selecting therapy stapler(TST)of hemorrhoids mucosa in the treatment of hemorrhoids.Methods A total of 150 patients with hemorrhoids admitted to Qingcheng People Hospital of Qingyuan City from January 2016 to December 2020 were selected as the research subjects.According to the random number table methods,they were divided into the control group(75 cases)and the observation group(75 cases).The control group was treated with procedure for prolapse and hemorrhoids(PPH),and the observation group was treated with modified TST.The operative conditions(operation time,intraoperative blood loss,hospital stay)and complications(anal stenosis,pain,etc.)of the two groups of patients were compared.Results The operation time and hospital stay of the observation group were shorter than those of the control group,and the intraoperative blood loss of the observation group was less than that of the control group,the differences were statistically significant(P＜0.05).The postoperative complication rate of the observation group was lower than that of the control group,the difference was statistically significant(P＜0.05).Conclusion Compared with PPH,modified TST has shorter operation time and hospital stay,less intraoperative bleeding,and lower incidence of postoperative complications such as anal stenosis and pain,and has higher clinical application value. 2021 Vol. 28 (27): 111-113 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 114 Clinical effect of total thyroidectomy in the treatment of multiple thyroid nodules LIU Xuan；WANG Bin；GUO Chun-peng；CHANG Xin；LI Xiao-bin；QIN Wei-jing Objective To investigate the clinical effect of total thyroidectomy in the treatment of multiple thyroid nodules.Methods A total of 100 patients with multiple thyroid nodules treated in our hospital from January 2018 to December 2019 were selected as the research objects.They were divided into the control group and the experimental group by random number table method,50 cases in each group.The control group was treated with subtotal thyroidectomy,and the experimental group was treated with subtotal thyroidectomy.The clinical effect,operation condition,thyroid function(including thyroid stimulating hormone[TSH],serum free T4[FT4],free T3[FT3])and adverse reactions were compared between the two groups.Results The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant(P＜0.05).The operation time,extubation time and discharge time of the experimental group were shorter than those of the control group,the differences were statistically significant(P＜0.05).The amount of intraoperative bleeding in the experimental group was less than that in the control group,the difference was statistically significant(P＜0.05).The indexes of TSH,FT4 and FT3 in the experimental group were lower than those in the control group,the differences were statistically significant(P＜0.05).The total incidence of adverse reactions in the experimental group was lower than that in the control group,the difference was statistically significant(P＜0.05).Conclusion Total thyroidectomy for multiple thyroid nodules is effective and safe. 2021 Vol. 28 (27): 114-116 [Abstract] ( 36 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 117 Application of multifunctional pain scale in cancer pain assessment XIONG Ping；SHEN Li-ping Objective To explore the application of multifunctional pain scale in cancer pain assessment.Methods A total of 60 patients with moderate and severe pain tumors admitted to Nanchang First Hospital from June to December 2020 were selected as the study subjects,thirty patients from June to October 2020 were used as control groups at the case selection time,and thirty patients from November to December 2020 were included as the experimental group.Numerical rating scale(NRS)was used for the control group,and multifunctional pain scale was used for the experimental group.The pain assessment effect,use effect evaluation of nurses,patient use effect evaluation,and time-consuming evaluation.were compared between the two groups.Results The effect of pain control in experimental group was 96.67%higher than that in control group 73.33%,the difference was statistically significant(P<0.05).The effect evaluation of nurses in experimental group was 96.67% higher than that in control group 73.33%,the difference was statistically significant(P<0.05).The effect evaluation of the experimental group was 100.00% higher than that of the control group 76.67%,the difference was statistically significant(P<0.05).The pain assessment time in the experimental group was(2.71±0.51)min shorter than that in the control group(4.95±0.62)min,the difference was statistically significant(P<0.05).Conclusion Multifunctional pain scale is used in cancer pain assessment,could improve the effect of pain control,shorten the pain assessment time,and improve the evaluation of nurses and patients′use effect. 2021 Vol. 28 (27): 117-119 [Abstract] ( 34 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 120 Significance of positive expression of three genes in peripheral blood nucleated cells of non-small cell lung cancer NONG Xue-ping Objective To study the expression of lung tissue-specific protein,cytokeratin 19 and calcium binding protein A4 in peripheral blood nucleated cells of patients with non-small cell lung cancer.Methods Each of 60 patients with confirmed lung benign and non-small cell lung cancer treated at Jiangxi Chest Hospital from March 2018 to December 2019 were respectively selected as study group 1 and study group 2.Then 60 healthy people of the same age who received physical examination in Jiangxi Chest Hospital during the same period were selected as the control group.The positive expression of lung tissue-specific protein,cytokeratin 19 and calcium binding protein A4 in peripheral blood nucleated cells of the three groups were detected by fluorescence quantitative PCR,and the detection results were compared.Results The levels of lung tissue-specific protein and calcium binding protein in the study 1 group were higher than those in the control group,the differences were statistically significant(P<0.05).The level of lung tissue-specific protein in the study 2 group was higher than that in the study 1 group,the difference was statistically significant(P<0.05).Three genes of expression of lung tissue-specific protein,cytokeratin 19,and calcium-binding protein A4 in peripheral blood nucleocytes in the study 2 group were higher than that in the study 1 group,the differences were statistically significant(P<0.05).Three genes of expression of lung tissue-specific protein,cytokeratin 19,and calcium-binding protein A4 in peripheral blood nucleocytes in the study 1 group were higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion The positive rates of lung tissue-specific protein,cytokeratin 19 and calcium binding protein A4 in peripheral blood nucleated cells of patients with nonsmall-cell lung cancer are significantly higher than those of patients with benign lung diseases and healthy people,which could be used as an important reference for the diagnosis and treatment of NSCLC. 2021 Vol. 28 (27): 120-122-126 [Abstract] ( 43 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 123 Clinical value of thoracoscopic resection of single-station N2-Ⅲa nonsmall cell lung cancer WANG Gang；YE Yong-qiang；XIE Bao-long；YE Hua-bin； CHEN Kai-xuan；XIE Chuan-hua Objective To explore the clinical value of thoracoscopic resection of single-station N2-Ⅲa non-small cell lung cancer(NSCLC).Methods A total of 50 NSCLC patients admitted to Ganzhou Cancer Hospital from July 2017 to August 2020 were selected as the research subjects.According to a random number table,they were divided into a thoracoscopy group(n=25)and a thoracotomy group(n=25).Patients in the thoracoscopy group were treated with thoracoscopic lobectomy + systematic mediastinal lymph node dissection,and in the thoracotomy group,they were treated with thoracotomy lobectomy + systematic mediastinal lymph node dissection.The clinical indicators,pain degree and complications of the two groups were compared.Results The postoperative hospital stay of the thoracoscopy group was shorter than that of the thoracotomy group with statistical significance(P<0.05).The visual analogue scale score of the thoracoscopy group was lower than those of the thoracotomy group on the 1st day，3rd day,and 5th day after surgery.The total incidence of complications in the thoracoscopy group was lower than that in the thoracotomy group with statistical significance(P<0.05).There were no statistically significant differences in the intraoperative blood loss,operation time,time of indwelling drainage tube,and the amount of drainage and the number of lymph node dissections in the two groups(P>0.05).Conclusion Thoracic surgery for single-station N2-Ⅲa NSCLC has the advantages of less damage,milder pain and fewer complications.It is beneficial to speed up the postoperative recovery of patients,and is safe and reliable for the treatment of patients with single-station N2-Ⅲa NSCLC. 2021 Vol. 28 (27): 123-126 [Abstract] ( 49 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 127 Application effect of different doses of Levothyroxine Tablets combined with iodine-131 in patients with differentiated thyroid cancer after operation HUANG Xiao-hua；WANG Yun-sheng Objective To investigate the application effect of different doses of levothyroxine tablets combined with iodine-131 in patients with differentiated thyroid cancer after operation.Methods A total of 180 patients with differentiated thyroid cancer treated by total thyroidectomy admitted to Fujian Geological Hospital from June 2014 to June 2015 were selected as the research objects,and divided into the control group(90 cases)and the observation group(90 cases)according to the dynamic random grouping method.The control group was treated with iodine-131 combined with 2.0 μg/kg Levothyroxine Tablets,and the observation group was treated with iodine-131 combined with 2.5 μg/kg levothyroxine tablets Levothyroxine tablets.The total effective rate,the levels of serum thyroid stimulating hormone(TSH),cluster of differentiation 44 variant 6(CD44V6),soluble interleukin-2 receptor(sIL-2R)and vascular endothelial growth factor(VEGF),the occurrence of adverse reactions and five year survival rate were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the TSH of the observation group was higher than that of the control group,the difference was statistically significant(P<0.05).The levels of CD44V6,SIL-2R and VEGF of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).The five year survival rate in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion Levothyroxine Tablets 2.5 μg/kg combined with iodine-131 in the treatment of postoperative patients with differentiated thyroid cancer has significant effect,which is suitable for clinical implementation and development. 2021 Vol. 28 (27): 127-129-132 [Abstract] ( 39 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 130 Analysis of the expression and clinical significance of E2F7 expression in lung adenoarinoma utilizing TCGA datasets ZHAO Qiu-rong；GUO Jing；CHEN Liang-yuan Objective To investigate the expression and clinical significance of transcription factor E2F7 in lung adenocarcinoma and its adjacent tissues.Methods The RNAseq data of 337 cases of lung adenocarcinoma tissues(tumor group)and 59 cases of paracancer tissues(para-cancer control group)and the corresponding clinical data of lung adenocarcinoma patients were downloaded from the cancer genome atlas(TCGA)database,and the expression of E2F7 in the data set was analyzed and processed.The correlation between E2F7 expression and clinicopathological features of lung adenocarcinoma and its influence on the prognosis were analyzed and compared,and evaluate independent risk factors for the prognosis in patients with lung adenocarcinoma through the COX risk ratio model.Results The expression level of E2F7 in the tumor group was significantly higher than that in the para-carcinoma control group(P<0.05).T Stage,N Stage and Stage were relevant factors in E2F7 expression(P<0.05).Survival analysis showed that patients with high expression of E2F7 in lung adenocarcinoma had a poor prognosis(P<0.05).The results of the multivariate COX risk ratio model results showed that high E2F7 expression level and Stage were independent risk factors for poor prognosis in patients with lung adenocarcinoma(P<0.05).Conclusion E2F7 may promote the occurrence and development of lung adenocarcinoma through various ways,thus affecting the prognostic survival of patients with lung adenocarcinoma.Therefore,E2F7 can be used as a prognostic marker or potential therapeutic target for patients with lung adenocarcinoma. 2021 Vol. 28 (27): 130-132 [Abstract] ( 40 ) HTML (28 KB)  PDF  (0 KB)  ( 7 ) 133 Application of ultrasound-guided positioning of catheter tip in PICC catheterization in premature infants YAN Ping-xia；LUO Yan；CHEN Rong；LI Sha Objective To investigate the application effect of ultrasound-guided positioning of catheter tip in the peripherally inserted central catheter(PICC)catheterization in premature infants.Methods A total of 30 premature infants admitted to the Department of Neonatology of the Pingxiang People′s Hospital from January 2019 to December 2020 were selected and divided into the observation group(15 patients)and the control group(15 patients)according to the random number table method.The observation group were given bedside ultrasound-guided positioning of catheter tip,and the control group were given X-ray radiography positioning.The operation time and intraoperative blood loss of PICC catheterization,success rate of PICC puncture,and total incidence of complications were compared between the two groups.Results The operation time in the observation group was shorter than that in the control group,and the intraoperative blood loss in the observation group was less than that in the control group,with statistically significant differences(P<0.05).The success rate of PICC puncture in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).The total incidence of complications in the observation group was lower than that in the control group,with statistically significant difference(P<0.05).Conclusion Ultrasound-guided positioning of catheter tip can significantly improve the success rate of PICC catheterization,shorten the catheterization time,and reduce the incidence of complications in preterm infants.It can be used as the first choice for PICC tip positioning in premature infants. 2021 Vol. 28 (27): 133-135-139 [Abstract] ( 38 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 136 Effect of pressure controlled lung recruitment combined with mechanical ventilation for volume targets in the treatment of neonatal respiratory distress syndrome CHEN Qi Objective To explore the effect of pressure controlled lung recruitment combined with volume guided mechanical ventilation in the treatment of neonatal respiratory distress syndrome(NRDS).Methods A total of 62 children with NRDS admitted to Shangrao maternal and child health hospital from January 2018 to December 2020 were selected as the research objects and divided into the control group and the experimental group by random number table methd,with 31 cases in each group.The control group was given pulmonary surfactant combined with volume guided mechanical ventilation within 6 hours after birth,and the experimental group was given pressure controlled lung recruitment on the basis of the control group.The respiratory parameters(partial pressure of carbon dioxide[PaCO2],partial blood oxygen pressure[PaO2],inhaled oxygen concentration[FiO2]),hemodynamic indexes(systolic blood pressure[SBP],heart rate[HR])and adverse reactions were compared between the two groups.Results Before treatment,there were no statistically significant differences in PaCO2,PaO2 and FiO2 levels between the two groups(P>0.05).After 1 and 6 h of treatment,the PaCO2 and FiO2 levels in the experimental group were lower than those in the control group,while PaO2 levels were higher than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in SBP and HR between the two groups at different time points before and after treatment(P>0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Pressure controlled lung recruitment combined with volume guided mechanical ventilation is effective in the treatment of NRDS children,which is conducive to improving respiratory parameters and maintaining hemodynamic stability without obvious adverse reactions,and is worthy of popularization and application. 2021 Vol. 28 (27): 136-139 [Abstract] ( 42 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 140 Effect of Iron Dextran Dispersible Tablets in the treatment of iron deficiency anemia during pregnancy ZHANG Fan；WANG Zhi-ping Objective To investigate the effect of Iron Dextran Dispersible Tablets in the treatment of iron deficiency anemia during pregnancy.Methods A total of 140 patients with iron deficiency anemia during pregnancy who were admitted to Qingyang People′s Hospital from January 2018 to January 2019 were selected as the research objects.They were divided into control group(70 cases)and observation group(70 cases)by dice method.The control group was treated with Ferrous Sulfate Tablet,and the observation group was treated with Iron Dextran Dispersible Tablets.The red blood cell(RBC),mean red blood cell volume(MCV),mean red blood cell hemoglobin(MCH)and hemoglobin(Hb)before and after treatment,the clinical efficacy and the total incidence of adverse reactions were compared between the two groups.Results After treatment,RBC,MCV,MCH and Hb in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Iron Dextran Dispersible Tablets can significantly improve the level of blood routine indexes,reduce the probability of adverse reactions in patients,and promote the improvement of the disease.It has an effective clinical application value. 2021 Vol. 28 (27): 140-142-146 [Abstract] ( 59 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 143 Effect of Prednisone combined with Levofloxacin in the treatment of cervicitis CHEN Jing-wen；WAN Min Objective To investigate the effect of Prednisone combined with Levofloxacin in the treatment of cervicitis.Methods From January 2018 to December 2019,100 patients with cervicitis in People′s Hospital of Yujiang District in Yingtan City,Jiangxi Province were selected as the research objects and divided into the control group and the study group by random number table method,with 50 cases in each group.The control group was treated with Levofloxacin,and the study group was treated with Prednisone combined with Levofloxacin.The clinical symptom relief time,efficacy,adverse reactions and inflammatory factor levels before and after treatment were compared between the two groups.Results The urethral discomfort,abnormal secretion,pruritus vulvae and pain relief time of lower abdomen in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Before treatment,there were no statistically significant differences in the levels of hypersensitive C-reactive protein(hs-CRP),interleukin-10(IL-10)and interleukin-2(IL-2)between the two groups(P>0.05).After treatment,the levels of hs-CRP,IL-10 and IL-2 in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of hs-CRP,IL-10 and IL-2 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The effect of Prednisone combined with Levofloxacin in the treatment of cervicitis is more ideal,which should be further promoted in clinical application. 2021 Vol. 28 (27): 143-146 [Abstract] ( 76 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 147 Clinical effect of Modified Feikening Decoction combined with aerosol inhalation on asthmatic bronchitis in children ZENG Yu-zhen；YANG Liu-chan；ZHOU Cai-yun Objective To investigate the clinical effect of Modified Feikening Decoction combined with aerosol inhalation in the treatment of children asthmatic bronchitis.Methods A total of 70 children with asthmatic bronchitis admitted to Dexing Traditional Chinese Medicine Hospital from January 2020 to February 2021 were selected as the study subjects,and divided into control group and observation group according to random number table method,with 35 cases in each group.The control group was treated with nebulized of Budesonide+Salbutamol,and the observation group was added with Modified Feikening Decoction.The clinical efficacy,improvement time of symptoms and signs,pulmonary function and the occurrence of adverse reactions were compared between the two groups.Results The total effectiveness rate of treatment in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The relief time of dyspnea,wheezing,shortness of breath,profuse phlegm,cough and lung wheeze in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in lung function between the two groups before treatment(P>0.05).After treatment,peak expiratory flow rate(PEF)in the morning and PEF in the evening in both groups were higher than before treatment,and PEF in the observation group in the morning and evening after treatment were higher than those in the control group,the differences were statistically significant(P<0.05).There was no statistical significance in the total incidence of adverse reactions between two groups(P>0.05).Conclusion Modified Feikening Decoction combined with aerosol inhalation can improve the treatment effect of asthmatic bronchitis in children,speed up the disappearance of symptoms and signs such as wheezing,and promote the recovery of lung function.It is safe and reliable,and it is worthy of wide application. 2021 Vol. 28 (27): 147-150 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 151 Application of self-made swaddling in the examination of retinopathy of premature infants ZHONG Fang；OUYANG Min； LI Wen；ZOU Qian-jian；LIAO Huan；LUO Xiao-hua Objective To explore the effect of self-made swaddling in the examination of retinopathy of prematurity(ROP).Methods A total of 100 premature infants who underwent ROP screening at Ganzhou Maternity and Child Health Hospital from January 2019 to January 2021 were selected and divided into two groups according to the random number table method,with 50 cases in each group.The control group was given nursing care according to the routine ROP screening method,and the test group was given self-made swaddling package on the basis of the control group to cooperate with the inspection.The time-consuming operation of examinations,the degree of pain after the examination,the total incidence of adverse events and the satisfaction from the families of premature infants between the two groups were compared.Results The inspection operation in the test group was shorter than that of the control group,the pain degree after examination of the test group was milder than that of the control group,the total incidence of adverse events in the test group was lower than that in the control group,with statistical significances(P<0.05).In the test group,the family satisfaction on the scores of self-made swaddling application,health guidance,service attitude,operating techniques and the total score were higher than those of the control group,with statistical significances(P<0.05).Conclusion The self-made swaddling used in the ROP examination of premature infants can shorten the examination time,alleviate the pain of the child,reduce the occurrence of unexpected situations,and improve the satisfaction of the family. 2021 Vol. 28 (27): 151-153-157 [Abstract] ( 53 ) HTML (33 KB)  PDF  (0 KB)  ( 10 ) 154 Clinical effect of pulmonary surfactant and noninvasive high frequency oscillatory ventilation on neonatal respiratory distress syndrome GENG Pei-hong Objective To explore the clinical effect of pulmonary surfactant and noninvasive high frequency oscillatory ventilation in the treatment of neonatal respiratory distress syndrome.Methods A total of 214 cases of neonatal respiratory distress syndrome treated in Shenyang Jishuitan Hospital from January 2018 to December 2020 were selected as the research objects.According to the random number table method,they were divided into the control group and the observation group,with 107 cases in each group.The control group was treated with pulmonary surfactant+normal frequency ventilation,and the observation group was treated with pulmonary surfactant+noninvasive high frequency oscillatory ventilation.The total effective rate,complication rate,arterial blood gas index levels(arterial partial pressure of oxygen[PaO2],pH,partial pressure of carbon dioxide[PaCO2],percentage of inhaled oxygen concentration[FiO2],oxygenation index[OI])before treatment and on the first day of treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of complications between the two groups(P<0.05).There were no statistically significant differences in PaO2,pH,PaCO2,FiO2,OI between the two groups before treatment(P>0.05).The PaO2 and pH value of the observation group on the first day of treatment were higher than those of the control group,the PaCO2,FiO2 and OI values of the observation group on the first day of treatment were lower than those of the control group,and the differences were statistically significant(P<0.05).Conclusion The clinical effect of pulmonary surfactant+non-invasive high frequency oscillatory ventilation in the treatment of neonatal respiratory distress syndrome is significant,which can effectively improve the arterial blood gas index level of children,promote the recovery of children,with fewer complications and high safety,which is worthy of promotion. 2021 Vol. 28 (27): 154-157 [Abstract] ( 48 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 158 Effect of laser combined with Conbercept in the treatment of diabetic macular edema ZHENG Lin-lu；GONG Li-miao；ZHAN Xin；LI Xun-yi；SU Wen-hua；YIN Qiao；MAO Yu-jia Objective To study the effect of laser combined with Conbercept in the treatment of diabetic macular edema(DME).Methods A total of 80 patients with DME admitted to the First Affiliated Hospital of Jiangxi Medical College from March 2019 to March 2020 were selected as the research objects,and divided into control group(40 cases)and experimental group(40 cases)according to random number table method.The control group received laser therapy,and the experimental group was combined with Conbercept therapy.Both groups were followed up for 3 months after treatment.The best corrected visual acuity(BCVA),central macular thickness(CMT)and total macular volume(TMV)of 6 mm were compared between the two groups before treatment,1 week,1 month and 3 months after treatment.Results There was no significant difference in BCVA level between the two groups before treatment(P>0.05).At 1 week,1 month and 3 months after treatment,BCVA levels in both groups were higher than before treatment,and BCVA levels in the experimental group were higher than those in the control group at 1 month and 3 months after treatment,the differences were statistically significant(P<0.05).There was no significant difference in CMT and TMV levels between the two groups before treatment(P>0.05).One week,one month and three months after treatment,the levels of CMT and TMV in both groups were lower than before treatment,and the levels of CMT and TMV in experimental group were lower than those in control group,the differences were statistically significant(P<0.05).Conclusion Laser combined with Conbercept can effectively reduce the level of CMT and TMV in DME patients,improve BCVA,and then improve the level of visual acuity correction,the curative effect is significant,clinical worth promoting. 2021 Vol. 28 (27): 158-160-164 [Abstract] ( 58 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 161 Therapeutic evaluation of Nd:YAG laser therapy on temporomandibular joint pain LIU Ran；SHANG Qing-yan；ZHOU Yan；CUI Xing▲ Objective To evaluate the effect of Nd:YAG laser therapy on temporomandibular joint pain.Methods A total of 90 patients with temporomandibular joint pain who were admitted to the Stomatological Hospital Affiliated Suzhou Vocational Health College from November 2019 to December 2020 were selected as the research subjects.The patients were divided into laser group(30 cases),control group(30 cases)and hot dressing group(30 cases)according to the random number table method.The laser group was treated with Nd:YAG laser irradiation,the control group was treated with fake Nd:YAG laser irradiation,and the hot compress group was treated with warm towel.The visual analogue scale(VAS)score,maximum opening,mandibular deflection and maximum extension motion before and after treatment were compared among the three groups.Results After treatment,VAS score of laser group was lower than that of control group and hot compress group,the difference was statistically significant(P<0.05).After treatment,the maximum opening degree and the maximum extension motion of the laser group were greater than those of the control group and the hot compress group,and the opening skew was less than that of the control group and the hot compress group,the differences were statistically significant(P<0.05).Conclusion Nd:YAG laser can effectively relieve the symptoms of temporomandibular joint pain and improve the degree of mandibular movement,which is a reliable and non-invasive treatment method,and is worth popularizing. 2021 Vol. 28 (27): 161-164 [Abstract] ( 35 ) HTML (35 KB)  PDF  (0 KB)  ( 5 ) 165 Effect of low-temperature plasma radiofrequency ablation on serum ET-1,GMP-140 and NO levels in children with snoring CAO Qi-you；ZHOU Chao；HU Yan Objective To investigate the effect of low-temperature plasma radiofrequency ablation on serum endothelin-1(ET-1),platelet membrane protein-140(GMP-140)and nitric oxide(NO)levels in children with snoring.Methods A total of 176 children with snoring admitted to Shangrao Municipal Hospital from May 2020 to February 2021 were selected as the study subjects,and divided into the observation group(88 cases)and the control group(88 cases)according to the random number table method.The control group was treated with tonsillectomy + nasal endoscopic adenoidectomy,and the observation group was treated with low-temperature plasma radiofrequential ablation.Quebec sleep questionnaire(QSQ)and Epworth sleepiness scale(ESS)were used to evaluate the sleep quality of the children,and the perioperative indicators,sleep quality and vascular endothelial function of the two groups were compared.Results The operative time,pain time and symptom relief time of the observation group were shorter than those of the control group,and the intraoperative blood loss was less than that of the control group,the differences were statistically significant(P<0.05).QSQ score of the observation group was higher than that of the control group,and ESS score was lower than that of the control group,the differences were statistically significant(P<0.05).The levels of ET-1 and GMP-140 in the observation group were lower than those in the control group,and the level of NO was higher than that in the control group,the differences were statistically significant(P<0.05).Conclusion The application of low-temperature plasma radiofrequency ablation for children with snoring has significant therapeutic advantages.It can reduce bleeding,relieve postoperative pain,and promote symptom relief.It can also effectively improve the quality of sleep in children and help the recovery of vascular endothelial function,and is an ideal treatment option,which is worthy of extensive clinical practice. 2021 Vol. 28 (27): 165-168 [Abstract] ( 45 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 169 Analysis on the situation of 140 strains of multidrug resistant bacteria in hospital and rational use of antibiotics for multidrug resistant bacteria infection CHEN Shao-fang；HONG Hui-qi；LUO Bei Objective To analyze the distribution of clinical departments and rationality of antibiotics in Shunde Hospital of Southern Medical University,in order to provide reference for the rational use of antibiotics for multidrug resistant bacteria infection.Methods A total of 140 patients with multidrug resistant bacterial infection hospitalized in Shunde Hospital of Southern Medical University from July 15,2020 to February 3,2021 were selected as the research objects.The source of their specimens,composition ratio of multidrug-resistant bacteria and department distribution were analyzed,and the rationality of using antibiotics for multidrug resistant bacterial infection was evaluated and analyzed.Results A total of 140 strains of multidrug resistant bacteria were detected.The most multidrug resistant bacteria were detected in sputum samples,followed by mid-stream urine,wound secretions and blood.Gram-negative bacteria were the main pathogenic bacteria(68.57%),followed by Gram-positive bacteria(31.43%).There were 47 cases of irrational drug use,the rate of irrational drug use was 33.57%.Distribution of irrational use of antibiotics:unsuitable drug selection in 32 cases(68.09%),9 cases(19.15%)were not suitable for usage and dosage,3 cases(6.38%)were unsuitable for drug combination,inappropriate route of administration in 2 cases(4.26%),the course of treatment was too long in 1 case(2.13%).Conclusion The rate of irrational use of antibiotics for multidrug resistant bacteria infection in Shunde Hospital of Southern Medical University is still high.For irrational use of drugs,the training of clinical rational use of antibiotics should be strengthened so as to promote the rational use of antibiotics infected by multidrug resistant bacteria. 2021 Vol. 28 (27): 169-172 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 173 Analysis of irrational drug use and countermeasures for ophthalmic outpatient and emergency department XU Chao-ran；CUI Fen-fang；QIN Xiao-li；XU Min Objective To analyze the irrational prescription in Ophthalmic Outpatient and Emergency Department in the Third People′s Hospital of Chengdu City,so as to provide the basis for optimizing prescription pre-review rules.Methods The prescription review system was used to screen out a total of 1717 irrational prescriptions in Ophthalmic Outpatient and Emergency Department in the Third People′s Hospital of Chengdu City from April to November 2019,and the results were analyzed by Pareto diagram.Results The main factor causing irrational prescription was the unsuitable route of administration,and the secondary factor was off-label.The rules for prescription pre-review should be optimized for specific drugs.Conclusion According to the analysis of the factors causing irrational prescription,pharmaceutical intervention should be targeted to improve the rational utilization rate of prescription and ensure the security use of drugs for patients. 2021 Vol. 28 (27): 173-176 [Abstract] ( 42 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 177 Clinical effect of Banxia Baizhu Tianma Decoction combined Chinese herbal foot massage in the treatment of refractory hypertension CHEN Guang-jin；LIANG Dou-xuan；LI Mei-hong Objective To explore the clinical effect of Banxia Baizhu Tianma Decoction combined Chinese herbal foot massage in the treatment of refractory hypertension.Methods A total of 90 patients with refractory hypertension admitted to Yangjiang Hospital of Traditional Chinese Medicine from January 2020 to December 2020 were selected as the research objects,and divided into the treatment group(45 cases)and the control group(45 cases)according to the random number table method.The control group was routinely given western medicine for antihypertensive treatment,and the treatment group was additionally taken on this basis Banxia Baizhu Tianma Decoction,combined with traditional Chinese medicine foot treatment.The antihypertensive effect,plasma renin activity(PRA)level,homocysteine(Hcy)level and improvement of TCM symptoms were compared between the two groups.Results There was no statistically significant difference in total efficiently compared between the two groups(P>0.05).The reduction of PRA and Hcy levels in the treatment group were higher than those in the control group,and the differences were statistically significant(P＜0.05).The total effective rate of symptom improvement was higher than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion Banxia Baizhu Tianma Decoction combined with traditional Chinese medicine foot massage is safe and effective to treat refractory hypertension.It could lower blood pressure,alleviate clinical symptoms,and reduce PRA and Hcy levels. 2021 Vol. 28 (27): 177-179 [Abstract] ( 53 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 180 Clinical effect on treating apoplectic hemiplegia with electroacupuncture combined with Dong′s unique extra-ordinary points LIU Ming-yang；LUO Shao-han；XIE Li-na；SU Ze-sheng Objective To observe the clinical effect of electroacupuncture combined with Dong′s unique extra-ordinary points in the treatment of stroke hemiplegia.Methods From January 2020 to February 2021,a total of 54 patients with hospitalized stroke in the Department of Rehabilitation,Chronic Disease Prevention Hospital of Qingyuan were selected as the research objects,and divided into the treatment group(27 cases)and the control group(27 cases)according to the random number table method.The control group was treated with electroacupuncture,and the treatment group was treated with electroacupuncture combined with Dong′s unique extra-ordinary points.After 3 weeks of treatment,Fugl-Meyer activity function(FMA),modified barthel index(MBI)score and manual muscle test(MMT)grades were compared between the two groups,and the clinical efficacy was evaluated.Results The total effective rate of the treatment group was higher than that of the control group,with statistically significant difference(P＜0.05).There were no significant differences in FMA,MBI scores and MMT grade between the two groups before treatment(P>0.05).After treatment,the FMA,MBI scores and MMT grade of both groups were higher than those before treatment in the groups,and the FMA,MBI scores and MMT grade of the treatment group were higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion The effect of electroacupuncture combined with Dong′s unique extra-ordinary points in the treatment of stroke hemiplegia is better than the simple electroacupuncture treatment. 2021 Vol. 28 (27): 180-183 [Abstract] ( 83 ) HTML (40 KB)  PDF  (0 KB)  ( 5 ) 184 Study on the influence of professional self-concept on perceived professional benefit of nursing students in vocational colleges LI Wen-jia；ZHAO Lei；WANG Qian-qian Objective In order to improve the stability of nursing team in the future,this paper investigated the influence of professional self-concept on perceived professional benefit of nursing students in vocational colleges.Methods From June to September 2019,a total of 532 nursing interns from Taishan Vocational College of Nursing were selected by convenience sampling method,professional self-concept of nurses instrument questionnaire and nurses′perceived professional benefits questionnaire were conducted.Results The score of professional self-concept of nursing students in vocational colleges was(86.61±10.06)points,and the total score of nurses′perceived professional benefits was(120.61±29.45)points.There was a positive correlation between professional self-concept and occupational benefit of nursing students.Conclusion Nurses′professional self-concept was in a positive state,and perceived professional benefits was in the middle level.Nursing educationers should to guide nursing interns to form positive professional selfconcept,to inhance the professional benefits and stability of nursing troop. 2021 Vol. 28 (27): 184-187 [Abstract] ( 36 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 188 Investigation and intervention study on cognitive status of 120 parents of infants with brain injury and interictal epilepsy ZHANG Yang-ping；LIU Yun；ZHOU Yi-qing；LI Quan-hong Objective To investigate the cognitive status of the parents of children with brain injury complicated with interpartic epileptiform discharge(IEDs)on the knowledge related to the disease,and to analyze the influence of education and intervention on the disease master and compliance.Methods A total of 120 parents of children with brain injury complicated with IEDs who visited Kunming Children′s Hospital from January 2018 to January 2019 were selected as the research objects,and questionnaires were conducted.The patients were divided into intervention group(60 cases)and control group(60 cases)by computer random sampling.The control group received routine follow-up,and the intervention group received intervention in the form of pamphlet distribution,parent training and regular telephone follow-up on the basis of routine follow-up.The cognition and treatment compliance of the two groups were compared before and after intervention.Results The survey showed that more than 95% of parents did not grasp the relevant knowledge of brain injury with IEDs before intervention.After the intervention,the intervention group had a higher degree of knowledge of all aspects of the disease than the control group,and the treatment compliance of the intervention group was higher than the control group,the differences were statistically significant(P<0.05).Conclusion Parents generally have low awareness of brain injury combined with IEDs,and there is an urgent need to carry out corresponding publicity and education interventions.Actively carrying out disease health education can help raise parents′awareness of the disease,improve treatment compliance,and improve the prognosis of the disease. 2021 Vol. 28 (27): 188-191 [Abstract] ( 46 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 192 Investigation and research on the cardiovascular system of high-temperature exposed workers in Nantong area QIAN Lei；DING Lu-ming Objective To investigate the cardiovascular system in high-temperature exposed workers in Nantong area,and to explore the influence of high-temperature work on the human cardiovascular system.Methods A total of 565 high-temperature exposed workers including welding,spraying,burning boilers,and sewage treatment in Nantong area for occupational health examinations from January to December 2020 were retrospectively selected as the high-temperature group,and 596 matching non-high-temperature exposed workers during the same period were selected as the control group.The general data,blood pressure and electrocardiogram(ECG)abnormality of the two groups were analyzed.Results The abnormal rate of blood pressure in the high temperature group was 21.24%,higher than that of in the control group accounting for 12.08%,the difference was statistically significant(P<0.05).The abnormal rate of ECG in the high temperature group was 16.46%,which was higher than that in the control group,accounting for 10.23%,and the difference was statistically significant(P<0.05).The abnormal rates of blood pressure and ECG in the each seniority subgroups of the high temperature group were all higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The damage of high temperature to the cardiovascular system of professional workers is credible,and the damage will continue to worsen with the increase of working hours.Therefore,it is necessary to strengthen the prevention and education of medical occupations and regular physical examinations for workers who work at high temperatures.Meanwhile,improvement of the self-care awareness in high-temperature workers is also of great significance. 2021 Vol. 28 (27): 192-194 [Abstract] ( 47 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 195 Application effect of process reengineering in the management of precision surgical instruments LOU Li-qiong；LIU Wei；GE Ming-li；LI Shu-ling；HU Guo-feng；LONG Han；AO Jie-qi Objective To explore the application effect of process reengineering in the management of precision surgical instruments.Methods A total of 5680 precision surgical instruments processed by Jiangxi Provincial People′s Hospital from July to December 2020 were selected as the research objects.They were divided into the control group(from July to September 2020,2832 cases)and the observation group(from October to December 2020,2848 cases).The precision surgical instruments in the control group were processed according to the ordinary operating procedures.The precision surgical instruments in the observation group were optimized in the operating procedures of the control group,and the entire process of precision surgical instruments from use,recycling to distribution was refined.The processing steps of two groups were the same.The qualified rate,damage rate and clinical department satisfaction of precision surgical instruments were compared between the two groups.Results The qualified rate of precision surgical instruments cleaning in the observation group(98.38%)was higher than that in the control group(92.02%),and the difference was statistically significant(P<0.05).The device damage rate in the observation group(0.53%)was lower than that in the control group(1.31%),and the difference was statistically significant(P<0.05).The clinical department satisfaction of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The application of the remanufacturing process of precision surgical instruments can improve the quality of precision surgical instruments reprocessing,reduce the rate of instrument damage,improve the satisfaction of the use of the department,and ensure safety of patients. 2021 Vol. 28 (27): 195-197-201 [Abstract] ( 39 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 198 Research on performance evaluation index design of single-machine management of large medical equipment WANG Hai-ning；ZHANG Ping；LIU Ye Large medical equipment plays an important role in the diagnosis and treatment of hospital.However,the management of these large-scale medical equipment in some hospitals is insufficient,and the overall problem of paying more attention to procurement than management leads to the reduction of the use efficiency of some large-scale medical equipment and the waste of medical resources.At the present stage,many public hospitals in China are facing greater development opportunities and challenges.This period is an important period to actively carry out hospital reform.At the same time,the drug bonus of public hospitals was cancelled,and the higher authorities required hospitals to further implement the hierarchical diagnosis and treatment.In such a development background,in order to ensure the stable and healthy development in the future,the hospital needs to change the management concept,from the traditional and extensive management mode to the new and refined management mode.Determine the scope of the study,this paper introduces the current hospital equipment management status quo,analysis of the necessity of strengthening management of large equipment,hospital design for large medical equipment management in the performance evaluation index system,and points out several security play function of measures of performance management system.Suggestions are put forward for future development,so as to further analyze the elaborating management of hospital. 2021 Vol. 28 (27): 198-201 [Abstract] ( 49 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 202 Application study on health management model based on whole disease cycle in management of patients with multidrug-resistant tuberculosis WANG Yan；WANG Fang-fang；LYU Yan-qing Objective To explore the application value of health management model based on the whole disease cycle in the management of patients with multidrug-resistant tuberculosis(MDR-TB).Methods A total of 60 patients with MDR-TB admitted to the Ganzhou Fifth People′s Hospital from July 2019 to July 2020 were selected as research subjects and divided into two groups according to random number table method,with 30 patients in each group.The control group was given routine nursing,and the observation group was given health management mode based on the whole disease cycle in addition to routine nursing.The rehabilitation effect,treatment compliance,quality of life and nursing satisfaction were compared between the two groups.Results The duration of treatment and hospitalization time in the observation group were(471.58±12.23)and(14.18±2.05)d,respectively,which were shorter than those in the control group of(512.23±18.47)and(19.43±3.27)d,the average hospitalization cost of the observation group was(1389.47±102.56)yuan,which was lower than that of the control group of(1856.38±125.45)yuan,the differences were statistically significant(P<0.05).The treatment compliance of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).Before intervention,there was no significant difference in quality of life questionnaire-30(QOL-30)and Newcastle scale of nursing satisfaction(NSNS)scores between the two groups(P>0.05).After intervention,the QOL-30 and NSNS scores of the observation group were(99.46±9.58)and(78.34±6.15)points,respectively,which were higher than those of the control group of(89.34±9.11)and(68.39±5.22)points,with statistical significances(P<0.05).Conclusion Health management model based on the whole disease cycle can improve the compliance of patients with MDR-TB,shorten treatment duration,reduce medical costs,and improve their quality of life and satisfaction with medical staff. 2021 Vol. 28 (27): 202-205 [Abstract] ( 43 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 206 Study of lean management model of outpatient and emergency pharmacy in maternity and child specialty hospital MU Yu；HUANG Ting；LIU Yu-qing；ZHAO Yun；WANG Ting-yu；LIU Tong；ZHOU Xiao-rui；SHI Xiang-kui As a new management mode,lean management is first applied in enterprise management.In view of its superiority,it was gradually introduced and used in the field of hospital pharmaceutical management.Related studies have found that lean management mode has the advantages of reducing medication errors and improving patient satisfaction,and its clinical effect is better than the conventional management when it is applied to hospital pharmacy management.Because of its particularity,drug safety is particularly important in maternal and child hospital.By sorting out the five measures of lean management of outpatient and emergency pharmacies,the author aims to provide a reference for the construction of lean management models for outpatient and emergency pharmacies of maternity and child specialty hospital. 2021 Vol. 28 (27): 206-209 [Abstract] ( 42 ) HTML (39 KB)  PDF  (0 KB)  ( 7 ) 210 Problems and countermeasures of pharmacy management in primary medical institutions XUE Yuan；YUAN Jie；LI Cui-hua；ZHANG Wei-jin Pharmacy as an important part of grassroots medical institutions,the stand or fall of management directly affects the quality of the medical security of basic-level medical organization,this paper studies the characteristics and regularity of the pharmacy management of medical institutions at the grassroots level analysis of the problems existing in the grassroots medical institutions pharmacy management and confused,and explore the methods and experience of the grassroots medical institutions pharmacy management.The problems of pharmacy management in primary medical institutions are summarized as follows: pharmacy management system is not perfect,drug management is not standard,and the professional level of pharmacists needs to be improved.To explore and analyze the corresponding measures to solve these difficulties are: perfect the management system,perfect the management mechanism;standardize the management process and implement the specific work;strengthen business training,improve personnel quality and other management countermeasures.Realized the specific improvement methods are: strengthen the professional quality of business personnel;strict prescription management and dispensing;strengthen window reception service;provide good medication consultation service.These explorations and experiences are of reference value to the improvement of pharmacy management in primary medical institutions. 2021 Vol. 28 (27): 210-213 [Abstract] ( 51 ) HTML (39 KB)  PDF  (0 KB)  ( 6 ) 214 Risk communication of plague control and prevention WEI Rong-jie;LI Fan;WU Chao-xue;ZHANG Yao;ZHU Xiao-ping;YANG Chang-hong Risk communication is a complicated social system engineering.It is an interactive process through which individuals,groups and institutions exchange information and ideas and is the basic health emergency capacity required by the International Health Regulations(2005).In this paper,the plague epidemic and public opinion characteristics would be analyzed,the practical risk communication strategies to the plague would be discussed.So to correctly guide the public opinion of plague and provide correct information of plague to the public in time,make people to participate to the plague risk communication actively.Then to enhance the plague risk communication effect,improve the comprehensive ability to plague prevention and control. 2021 Vol. 28 (27): 214-217 [Abstract] ( 28 ) HTML (1 KB)  PDF  (0 KB)  ( 7 ) 218 Correlation analysis of health literacy,self-management and quality of life in patients with coalworker pneumoconiosis LIU Qi;DENG Shan;MI Ting Objective To analyze the correlation of health literacy,self-management and quality of life in patients with coalworker pneumoconiosis(referred to as pneumoconiosis).Methods Sixty patients with pneumoconiosis admitted to the Pingxiang Third Hospital from January 2018 to January 2020 were selected as the research subjects.The questionnaire was used to conduct the survey.The questionnaire contained three parts,namely the chronic disease quality of life specific scale,chronic disease self-management behavior scale,and chronic disease health literacy questionnaire.Various factors were summarized and linear regression was used for multi-factor analysis to clarify the correlation between self-management,health literacy and quality of life of patients with pneumoconiosis.Results There was a positive correlation between the total score of health literacy of patients with pneumoconiosis and cognitive symptom management and exercise in self-management behavior(r=0.353,0.254, P<0.05).In patients′health literacy,there was a positive correlation between the willingness to improve health and their quality of life score(r=0.159, P<0.05).In self-management behavior,there was a negative correlation between exercise and quality of life scores(r=-0.250, P<0.05).Conclusion There is a close relationship among the health literacy,self-management and the quality of life in patients with coalworker pneumoconiosis. 2021 Vol. 28 (27): 218-220 [Abstract] ( 49 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 221 Analysis and thinking of the incorporate the concept of benevolence into clinical teaching LI Yan-yan;QIAN Yun With the change of medical model,the humanistic quality education of clinical learning physicians needs to be strengthened urgently.Integrating the concept of benevolence into clinical teaching and strengthening clinical study physician′s humanistic quality education is the need to build a harmonious doctor-patient relationship and reduce medical disputes.It can compensate for the lack of humanistic quality education and promote the sustained and healthy development of medical science education.It can also improve the hospital working atmosphere and implement peopleoriented health service.It can enhance staff basic quality,prevent corruption,and reduce crime tendency as well.Strengthening the humanistic quality education of clinical learning physicians could be realized by strengthening the construction of benevolence education leadership in all clinical practice bases,increasing the proportion of medical humanities education,improving the humanistic quality of teachers,enhancing the roles of model demonstration effect,establishing the evaluation system of humanistic quality education for clinical learning physicians and other ways.Finally,a new generation of medical workers inheriting the spirit of “benevolence” will be successfully trained. 2021 Vol. 28 (27): 221-224 [Abstract] ( 53 ) HTML (35 KB)  PDF  (0 KB)  ( 4 ) 225 Application of PBL teaching method based on hierarchical teaching mode in oral implant clinical teaching XIONG Yi;ZHOU Feng;WU Ying-ying Problem-based learning(PBL)is a heuristic teaching method that cultivates new clinical thinking.And the main body and core in PBL are students and medical records.However,in the clinical teaching of dental implantology,because students usually graduate from different schools and grades,they are different in learning capacity and needs,which brings new challenges to the application of the PBL model.Therefore,the application of hierarchical teaching mode is conducive to the further development and application of PBL.This article begins with the establishment of the hierarchical teaching model,introduces the application methods of PBL based on the hierarchical teaching model,and explains its shortcomings and difficulties,in order to provide reference for the future development of dental implant clinical education. 2021 Vol. 28 (27): 225-228 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 229 Construction of laboratory safety education and training system during the transfer period of independent colleges ZONG Xi-cui;ZHANG Yi;FANG Peng-hua Laboratory safety education is an effective method to improve the level of laboratory safety management,to strengthen the security awareness of teachers and students,and to reinforce emergency handling of safety accidents.It can fundamentally reduce the incidence of safety accidents and is the concrete manifestation of implementing the safety management policy of "safety first and prevention priority".In order to implement safety education,Nanjing University of Chinese Medicine Hanlin Academy discusses how to integrate safety education into the whole process of practical education from the systematic construction of laboratory safety education,training objectives,training content,training form,the formation of safety education culture and other aspects.Ensure that laboratory safety education becomes the routine content of laboratory education,ensure the normal operation of laboratory safety,provide firm guarantee for the development of basic medical experimental center,and gradually realize the construction of laboratory safety culture system. 2021 Vol. 28 (27): 229-231-235 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 232 Application and analysis of ″ student -centered″ teaching concept in gynecology teaching of traditional Chinese medicine MA Xiu-lan;HAN Lu▲ In the course of traditional Chinese medicine(TCM)gynecology teaching,adhering to the ″student-centered″concept,by adopting a variety of teaching methods,it stimulates students′enthusiasm for learning,improves students′learning ability,and cultivates students′lifelong learning habits,which helps improve teaching effect,training qualified successors in the career of Chinese medicine.The ″student-centered″ teaching concept breaks the way teachers instill knowledge in the classroom,increases classroom interaction,and enables teachers to better understand the needs of students and the degree of mastery of teaching content promotes teachers′exploration of teaching models and teaching methods to improve teaching effectiveness.Therefore,the application of ″ student-centered″ in the teaching of gynecology in traditional Chinese medicine is an inevitable demand for teaching proficiency. 2021 Vol. 28 (27): 232-235 [Abstract] ( 38 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 236 Effect study of instructional ward rounds in the form of clinical teaching unit among interns XU Zhen-e;HUA Zi-yu;LI Qiu;YU Geng-sheng;WEI Hong Objective To explore the effect of teaching ward rounds in the form of clinical teaching unit(CTU)among interns.Methods A total of 160 interns in Children′s Hospital Affiliated to Chongqing Medical University from January to December 2020 were selected as research subjects,they were divided into the observation group and the control group by random number table method,80 cases in each group.The observation group adopted CTU form of teaching rounds,the control group underwent ward rounds with traditional teaching.The scores of clinical thinking ability,comprehensive evaluation scores and teaching satisfaction scores between the two groups were compared.Results The scores in the three dimensions of clinical thinking of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).The scores cooperation,ability assessment and learning attitude of the observation group were higher than those of the control,the differences were statistically significant(P<0.05).At the end of the rotation,the satisfaction with teaching methods,overall performance,self-learning ability,their own communication ability,clinical skills,self-learning ability and other aspects of the observation group were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion CTU can significantly improve the clinical thinking ability and comprehensive ability of interns,and effectively improve the interns′satisfaction with the improvement of teaching methods and their own abilities,which is worthy of application and promotion in teaching activities. 2021 Vol. 28 (27): 236-238-242 [Abstract] ( 51 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 239 Study on the effect of incentive health education model on the management of type 2 diabetes patients in community HUANG Ying;LIU Dan Objective To observe the effect of applying the incentive health education model on the clinical efficacy and health literacy improvement of type 2 diabetes patients in the community.Methods A total of 160 patients with type 2 diabetes who were managed in Xiluoyuan Community Health Service Center,Fengtai District,Beijing from December 2018 to December 2019 were selected as the research subjects,and they were divided into the observation group(n=80)and the control group(n=80)by random number table method.The control group was received routine health education management,and the observation group was received incentive health education mode on the basis of routine management.One year later,the management effect of the two groups was compared.Results There was no statistically significant difference in baseline data(age,gender composition,education level,course of disease,blood sugar,blood pressure,and blood lipid)between the two groups(P＞0.05).The observation group′s blood pressure and combined index compliance rate were higher than those of control group,and the differences were statistically significant(P<0.05).The diabetes specific quality of life scale(DSQL)score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The management compliance of the observation group was higher than that of the control group,the attainment rate of health literacy standards of the observation group was higher than that of the control group,and the differences were statistically significant(P<0.05).Conclusion The application of incentive health education model has a significant effect on the comprehensive management of diabetic patients and it is worth promoting in the community. 2021 Vol. 28 (27): 239-242 [Abstract] ( 45 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 243 Application effect of clinical path teaching method in orthopedic nursing practice teaching LIANG Jun-hua Objective To explore the application effect of clinical path teaching method in orthopedic nursing practice teaching.Methods A total of 96 nursing students who practiced in Guangzhou Liwan Central Hospital from January 2017 to August 2019 were enrolled,and were divided into the control groups and the observation groups according to the random number table method,48 cases in each group.The control group implemented the traditional conventional teaching method,and the observation group implemented the clinical path teaching method,and the teaching time was 1 month.The theory implementation,practical operation skills and satisfaction were compared between two groups.Results After 1 months teaching,the assessment scores in each dimension of the theoretical knowledge of the observation group were higher than those of the control group,and the differences were statistically significant(P＜0.05）.Indwelling after 1 month of teaching needle infusion,fracture site fixation,bone traction,and drainage bag replacement performance in practice operations were higher than those of the control group,and the differences were statistically significant(P＜0.05）.Overall satisfaction with the work of nursing students after teaching was higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Carrying out clinical path teaching method in orthopedic nursing practice teaching can improve the theoretical knowledge level of nursing students,improve practical operation skills,and the satisfaction of nursing workers is high. 2021 Vol. 28 (27): 243-245 [Abstract] ( 37 ) HTML (30 KB)  PDF  (0 KB)  ( 9 ) 246 Application of different postpartum nursing in patients with hypertensive disorder complicating pregnancy XIAO Zhang;ZHONG Li-qun;CHEN Juan Objective To explore the application of different postpartum nursing in patients with hypertensive disorder complicating pregnancy.Methods A total of 70 patients with pregnancy induced hypertension in the First Affiliated Hospital of Gannan Medical University from January 2019 to December 2020 were selected and divided into two groups according to random number table method,35 patients in each group.The control group was given routine nursing,the observation group was given postpartumomni-directional nursing on this basis.The total amount of postpartum hemorrhage,the time for postpartum blood pressure to return to normal and satisfaction were compared between the two groups,and the incidence of postpartum complications and the scores of blood pressure,self-rating anxiety scale and self-rating depression scale before and after nursing were compared.Results The total amount of postpartum hemorrhage in the observation group was less than that in the control group,the difference was statistically significant(P<0.05).The time of postpartum blood pressure returning to normal in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The total satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of postpartum complications in the observation group was lower than that in the control group,the scores of blood pressure,self-rating anxiety scale and self-rating depression scale in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Postpartum omni-directional nursing has a definite effect on the nursing of hypertensive disorder complicating pregnancy,which can reduce the total amount of postpartum hemorrhage,effectively control blood pressure,improve patients′satisfaction,reduce patients′anxiety and depression,and reduce the occurrence of postpartum complications.It′s worth popularizing. 2021 Vol. 28 (27): 246-248-252 [Abstract] ( 41 ) HTML (35 KB)  PDF  (0 KB)  ( 5 ) 249 Improvement of moxibustion box at specific acupoints combined with critical thinking nursing on rehabilitation effect of hemorrhoid surgery HU Ping-hua；WANG Li-mei；HE Yuan-fang；YAN Quan-hai；ZHANG Min Objective To analyze the nursing effect of moxibustion box at specific acupoints(MBSA)combined with critical thinking nursing(CTN)for hemorrhoid patients.Methods A total of 80 patients with hemorrhoid surgery in Shangrao Hospital of Traditional Chinese Medicine from January to December 2020 were selected as the research subjects.They were divided into the observation group(40 cases)and the control group(40 cases)by random number table method.Patients in the observation group were treated with MBSA combined with CTN on the basis of the control group,while patients in the control group were treated with conventional nursing.The intervention time of the two groups was three months.The excellent and good nursing effective rate,incision healing time,nursing satisfaction,pain score,and depression score were compared between the two groups.Results The excellent and good nursing effective rate in the observation group(95.00%)was higher than that in control group(77.50%)after three months of nursing,the difference was statistically significant(P<0.05).Incision healing time of observation group was shorter than that of control group after two weeks of nursing,the difference was statistically significant(P<0.05).The nursing total satisfaction of the observation group(97.50%)was higher than that of the control group(82.50%)after three months of nursing,the difference was statistically significant(P<0.05).There were no statistical significance in the pain score or the self-rating depression scale(SDS)score between the two groups before the nursing(P＞0.05).After a week of nursing,the pain score of the observation group was lower than that of the control group,and the SDS score of the observation group was lower than that of the control group,and the differences were statistically significant(P<0.05).Conclusion MBSA combined with CTN for hemorrhoid patients can promote incision healing,relieve postoperative pain and depression,and improve nursing effect and satisfaction. 2021 Vol. 28 (27): 249-252 [Abstract] ( 34 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 253 Influence of participatory nursing combined with empathy nursing on senile depression patients LI Jie；XU Qing-yi；ZHAO Zi-yu；ZOU Chun-hui Objective To explore the influence of participatory nursing combined with empathy nursing on senile depression patients.Methods A total of 106 elderly depressed patients treated in Shenyang Watson Mental Health Center from August 2019 to February 2021 were selected as the research subjects.According to the coin toss method,they were divided into the control group(n=50)and the observation group(n=56).The scores of Hamilton depression scale(HAMD),nurses observation scale for inpatient evaluation(NOSIE),quality of life and coping style were observed before and after the intervention of the two groups.The compliance of the two groups was also observed.Results Before the intervention,there were no significant differences in scores of HAMD,NOSIE,quality of life and coping style between the two groups(P＞0.05).After the intervention,quality of life scores and coping style scores of the two groups were higher than those before the intervention,the NOSIE scores and the HAMD scores were lower than those before the intervention,quality of life score and coping style score of the observation group were higher than those of the control group,the NOSIE score and the HAMD score were lower than those of the control group,the differences were statistically significant(P<0.05).The total compliance of the observation group was higher than that of the control group,the differences was statistically significant(P<0.05).Conclusion Participatory nursing combined with empathy nursing applied to elderly patients with depression can improve depressive emotions,enhance the quality of life and coping ability,and increase compliance. 2021 Vol. 28 (27): 253-255-260 [Abstract] ( 34 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 256 Application of health education in interventional therapy for elderly patients with coronary heart disease and its influence on patients′treatment compliance SONG Jin-ling；ZHANG Ping；JI Yu-mei Objective To explore the application of health education in interventional therapy for elderly patients with coronary heart disease(CHD)and its influence on patients′treatment compliance.Methods The clinical information of 98 elderly patients with CHD undergoing interventional therapy in Dalian Third People′s Hospital from August 2018 to February 2020 were analyzed retrospectively.The patients were divided into the control group(n=49)and the research group(n=49)according to the care method.The routine care was given to the control group,and the routine care plus strengthening health education was given to the research group.The negative emotion scores,the clinical symptom improvement,the treatment compliance,and the overall self-efficacy levels in the two groups were compared.Results There were no statistically significant differences in the anxiety and depression scores before care between the two groups(P＞0.05);the anxiety and depression scores after care in the two groups were lower than those before care,the anxiety and depression scores after care in the research group were lower than those in the control group,with statistical differences(P<0.05）.There were no statistically significant differences in the frequency of angina,the duration time of angina,and the angina pain score before care between the two groups(P＞0.05);the frequency of angina after care in the two groups were less than those before care,the duration time of angina after care in the two groups were shorter than those before care,the angina pain score after care in the two groups were lower than those before care,the frequency of angina after care in the research group was less than that in the control group,the duration time of angina after care in the research group was shorter than that in the control group,and the angina pain score after care in the research group was lower than that in the control group,with statistical differences(P＜0.05）.The treatment compliance after care in the research group was higher than that in the control group,the overall self-efficacy level after care in the research group was higher than that in the control group,with statistical differences(P<0.05）.Conclusion The effect of health education in the interventional therapy for elderly patients with CHD is significant.It can improve patients′negative emotions and clinical symptoms,and can also enhance patients′compliance and self-efficacy,which should be popularized and applied. 2021 Vol. 28 (27): 256-260 [Abstract] ( 41 ) HTML (42 KB)  PDF  (0 KB)  ( 7 ) 261 Application effect of multidisciplinary cooperative nursing model in neurogenic rectal constipation after spinal cord injury LIN Yan-hua Objective To explore the application effect of multidisciplinary cooperative nursing（MDT)mode in neurogenic rectal constipation after spinal cord injury.Methods A total of 60 patients with neurogenic rectum after spinal cord injury in Liuzhou People′s Hospital from January 2017 to December 2018 were selected as the research objects and divided into the control group(30 cases)and the observation group(30 cases)according to random number table method.The control group was given routine nursing intervention,and the observation group was given MDT mode on the basis of the control group.The intervention time was 4 weeks.Constipation assessment scale,constipation related quality of life score and self-efficacy were compared between the two groups after 4 weeks of nursing intervention.Results The constipation assessment scale score and constipation related quality of life score of the observation group were lower than those of the control group,and the self-efficacy level of the observation group was higher than that of the control group,the differences were statistically significant(P<0.05).There were no significant differences in constipation score,constipation related quality of life score and self-efficacy between the two groups(P＞0.05).Conclusion The application of MDT mode in patients with neurogenic rectal constipation after spinal cord injury can reduce the incidence of constipation,improve the self-efficacy and quality of life of patients. 2021 Vol. 28 (27): 261-263-268 [Abstract] ( 42 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 264 Application research on early pulmonary rehabilitation grading nursing scheme for patients undergoing cardiac surgery XU Wen-hui；WANG Ya-jing Objective To observe the effect of early pulmonary rehabilitation grading nursing scheme on the enhanced recovery in intensive care unit(ICU)of patients undergoing cardiac surgery.Methods A total of 60 patients scheduled for cardiac surgery in ICU from June 2018 to June 2020 in North Hospital of Huashan Hospital Affiliated to Fudan University were selected and divided into the control group(n=30)and the test group(n=30)by random number table method.The control group adopted routine nursing scheme and the test group adopted early pulmonary rehabilitation grading nursing scheme on the basis of routine nursing scheme.The operation condition(operation duration,intraoperative bleeding volume,intraoperative fluid infusion volume,intraoperative urine volume),lung ventilation indexes(oxygenation index,arterial partial pressure of oxygen[PaO2],arterial partial pressure of carbon dioxide[PaCO2],lactic acid value),pneumonia-related inflammation indexes(C reactive protein[CRP],procalcitonin[PCT],white blood cell count[WBC])before and after nursing intervention were compared.Further,the incidence of complications,ICU duration and nursing satisfaction of patients were recorded.Results There were no statistically significant in operation duration,intraoperative bleeding volume,intraoperative fluid infusion volume and intraoperative urine volume between two groups(P＞0.05).After nursing intervention,the oxygenation index,PaO2 of test group were higher than those of the control group,PaCO2 and lactic acid value lower than those of the control group,the differences were statistically significant(P<0.05).Also,the serum CRP,PCT,WBC levels in test group were lower than those of the control group after nursing intervention,the differences were statistically significant(P<0.05).Moreover,ICU duration time of the test group was shorter than that of the control group,complications incidences was lower than that of the control group,satisfaction in nursing was higher than that of the control group,the differences were statistically significant(P<0.05).Conclusions Early pulmonary rehabilitation grading nursing scheme can significantly improve the respiratory function and prognosis and reduce the occurrence of postoperative complications of cardiac surgery patients during ICU,which is safer and more effective. 2021 Vol. 28 (27): 264-269 [Abstract] ( 50 ) HTML (44 KB)  PDF  (0 KB)  ( 8 ) 269 Effect of continuous midwife care combined with maternal weight management during pregnancy on maternal negative emotions and maternal and infant outcomes XU Hui Objective To explore the effect of continuous nursing by midwives combined with weight management during pregnancy on maternal negative emotions and maternal and infant outcomes.Methods A total of 180 primiparas admitted to Women and Children′s Hospital Affiliated to Xiamen University from February 2019 to February 2020 were selected as the research objects.According to random number table method,they were divided into the control group(90 cases)and the experimental group(90 cases).The control group was treated with routine nursing method,and the experimental group was treated with midwife continuous nursing combined with pregnancy weight management method.The negative emotions and maternal and infant outcomes of primiparas in the two groups were compared.Results The incidence of pregnancy complications in the experimental group was lower than that in the control group,and the vaginal delivery rate was higher than that in the control group,the differences were statistically significant(P<0.05).The incidence of negative emotions in the experimental group was lower than that in the control group,the incidence of macrosomia and low weight infants in the experimental group was lower than that in the control group,and the differences were statistically significant(P<0.05).Conclusion Midwife continuous care combined with weight management during pregnancy can help to eliminate or reduce the negative emotions of primiparas about the upcoming birth and improve the maternal and infant outcomes after delivery. 2021 Vol. 28 (27): 269-272 [Abstract] ( 45 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 273 Application effect of ERAS-derived nursing interventions in the perioperative period of ureteroscopic holmium laser lithotripsy MA Jin；LI Ya-jie；LI Jing-zhu；YANG Yuan Objective To investigate the clinical effect of implementing the ERAS-derived nursing interventions during the perioperative period of ureteroscopic holmium laser lithotripsy.Methods A total of 96 patients with ureteral stones hospitalized in the Hospital of the 75th Army of PLA from July 2017 to January 2019 were selected as study subjects.They were divided into the study group(n=46)and the control group(n=50)by coin toss method.The study group received the ERAS-derived nursing interventions and the control group received the traditional nursing interventions.Terms of surgical duration,the time of first anal exhaust after surgery,postoperative complications,length of stay,total hospital expenses,the concentrations of markers of inflammation and tissue damage,the pain scores after surgery(NRS),the score of daily living ability(ADL),and the satisfaction scores for responsible nurses between two groups were compared.Results The time of first anal exhaust after surgery,the NRS scores at 6 and 24 h after surgery,the white blood cell counts and the concentration of c-reactive protein of venous blood,the postoperative hospitalization days and the total hospitalization expenses of patients in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The scores of ADL and the satisfaction scores of responsible nurses in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion Implementing the ERAS-derived nursing interventions during the perioperative period of ureteroscopic holmium laser lithotripsy can significantly accelerate the recovery of patients and promote the harmony between doctors and patients,which is worthy of clinical promotion. 2021 Vol. 28 (27): 273-276 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 6 )

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