高压氧联合银杏叶提取物对突发性耳聋患者血清学指标及听力水平的影响

Abstract
Figure/Table
References (21)
Related Citation (15)

Download: PDF (0 KB) HTML (39 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical effect of hyperbaric oxygen combined with Ginkgo Biloba Extract in the treatment of sudden hearing loss(SHL)and its influence on hearing level.Methods A total of 88 SHL patients admitted to eople′s Hospital of Ganzhou City from October 2018 to October 2020 were selected as the research objects and divided into the control group and the observation group according to the random number table method,with 44 cases in each group.Both groups received conventional treatment,the control group was treated with Ginkgo Biloba Extract,and the observation group was treated with hyperbaric oxygen based on the basis of the control group.The serum indexes,hemorheology indexes,hearing level and adverse reactions were compared between the two groups.Results There were no statistically significant differences in serum indexes between the two groups before treatment(P>0.05).After treatment,the levels of nitric oxide(NO)and superoxide dismutase(SOD)in the two groups were higher than those before treatment,and the levels of C-reactive protein(CRP)and lipid peroxide(LPO)were lower than those before treatment,the differences were statistically significant(P<0.05).After treatment,the levels of NO and SOD in the observation group were higher than those in the control group,the levels of CRP and LPO were lower than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in hemorheology between the two groups(P>0.05).After treatment,plasma viscosity(PV),whole blood high shear viscosity(HSV)and low shear viscosity(LSV)of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,PV,HSV and LSV in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no statistica lly significant differences in hearing levels between the two groups before treatment(P>0.05).After treatment,the hearing threshold of high frequency region and low frequency region of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the hearing threshold in the high-frequency region and low-frequency region of the observation group were lower than those of the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P<0.05).Conclusion The treatment of hyperbaric oxygen combined with Ginkgo Biloba Extract can improve the serum indexes,correct abnormal hemorheology,and promote the recovery of hearing level in SHL patients,which is safe and reliable.

Key words： Sudden hearing loss Hyperbaric oxygen Ginkgo Biloba Extract Serological indicators Hearing level Adverse reactions

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	HUANG Zhen-he
	WANG Xin-tao
	YOU Long-gui
	ZHANG Ke-hui
	WANG Fu-hua

Cite this article:

HUANG Zhen-he,WANG Xin-tao,YOU Long-gui, et al. Effect of hyperbaric oxygen combined with Ginkgo Biloba Extract on serum indexes and hearing level of patients with sudden deafness[J]. 中国当代医药, 2021, 28(27): 10-13.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I27/10

[1]	陈菲，朱艳香，刘文彬，等.鼓室注射辅助全身应用糖皮质激素联合高压氧治疗突发性耳聋的疗效[J].临床与病理杂志，2019，39（10）：2182-2187.
[2]	江海丽，陈佳，孟德静，等.巴曲酶联合高压氧治疗老年突发性耳聋的效果及相关影响因素[J].中华老年多器官疾病杂志，2020，19（9）：675-679.
[3]	衣磊，訾定京.银杏叶注射液鼓室内注射联合高压氧治疗老年突发性耳聋疗效观察[J].海南医学，2020，31（4）：484-487.
[4]	于玲，徐静.银杏叶提取物治疗突发性耳聋气滞血瘀证临床研究[J].中医学报，2018，33（1）：145-148.
[5]	孙文佳，解光艾，罗彬，等.高压氧治疗突发性耳聋的疗效及疗程选择[J].中华航海医学与高气压医学杂志，2020，27（1）：69-71，78.
[6]	赵彩梅.高压氧治疗突发性耳聋的疗效观察[J].中国药物与临床，2019，19（10）：1701-1702.
[7]	中华耳鼻咽喉头颈外科杂志编辑委员会，中华医学会耳鼻咽喉头颈外科学分会.突发性聋诊断和治疗指南（2015）[J].中华耳鼻咽喉头颈外科杂志，2015，50（6）：443-447.
[8]	金凤，顾向阳，霍俊.长春西汀联合纤溶酶治疗突发性耳聋的临床研究[J].现代药物与临床，2019，34（5）：1440-1445.
[9]	班正锋.甲泼尼龙琥珀酸钠耳后注射治疗突发性耳聋的疗效观察[J].医学临床研究，2017，34（1）：171-173.
[10]	陈翠霞，唐玉艳，周军，等.甲强龙联合利多卡因对突发性耳聋鼓室注射疗效的研究[J].中国医学创新，2019，16（22）：148-153.
[11]	阿不都许库尔·吾买尔，王祥升，姜蕊蕊.银杏叶提取物注射液联合倍他司汀治疗突发性耳聋的疗效观察[J].现代药物与临床，2018，33（10）：2677-2680.
[12]	张红杰，霍岩，王珊珊.银杏叶提取物注射液联合马来酸桂哌齐特治疗突发性耳聋的效果[J].中国医药导报，2019，16（34）：149-152，160.
[13]	洪娴.评价银杏叶提取物注射液治疗突发性聋的临床疗效[J].中国中西医结合耳鼻咽喉科杂志，2019，27（2）：100-101，121.
[14]	叶美婷，付文洋，丁盼，等.银杏叶提取物治疗突发性感音神经性聋临床疗效及对血液流变学的影响[J].中国耳鼻咽喉头颈外科，2018，25（12）：660-663.
[15]	杨巍，刘亚峰，周志强.葛根素对突发性耳聋患者LPO、SOD、6-Keto-PGF1a、TXB2 水平的影响[J].中华保健医学杂志，2018，20（2）：144-146.
[16]	王敏，雷磊.龙胆泻肝丸联合地塞米松治疗老年突发性耳聋的疗效及对血管内皮功能的影响[J].现代中西医结合杂志，2020，29（6）：652-655，666.
[17]	王慧敏，余文发，周航，等.银杏叶片联合高压氧对老年突发性耳聋患者血清CRP 水平影响及临床疗效研究[J].中华中医药学刊，2017，35（5）：1246-1249.
[18]	张会芳.益气聪明汤联合高压氧治疗突发性耳聋疗效观察[J].现代中西医结合杂志，2017，26（18）：2025-2027，2040.
[19]	宗敏茹，庞灵，王研，等.不同压力高压氧治疗突发性耳聋的疗效观察[J].中华航海医学与高气压医学杂志，2018，25（1）：40-41.
[20]	李艺梅，石柱，冯江.前列地尔联合高压氧治疗突发性耳聋临床观察[J].临床误诊误治，2017，30（9）：88-90.
[21]	吴海导，胡永成.血塞通和激素静脉滴注联合高压氧治疗突发性感音神经性聋的临床效果[J].中国当代医药，2019，26（11）：130-132.