血清抵抗素、鸢尾素对妊娠期糖尿病产后血糖转归的预测价值

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Abstract Objective To explore the expression of Resistin and Irisin in serum of patients with gestational diabetes mellitus(GDM)and the value of predicting the outcome of postpartum blood glucose in patients with GDM.Methods A total of 183 patients with GDM who were examined and hospitalized for delivery in the Affiliated Hospital of Southwest Medical University from January 2019 to June 2020 were selected.They were divided into good outcome group(103 cases)and bad outcome group(80 cases)according to their blood glucose outcomes at 8 weeks after delivery.Enzyme linked immunosorbent assay was used to detect serum Resistin and Irisin levels,and multi-factor logistic regression was used to analyze the influencing factors of poor postpartum blood glucose outcome in GDM patients.ROC curve was plotted to analyze the diagnostic value of serum Resistin and Irisin expression in poor postpartum blood glucose outcome in GDM patients.Results The pre-pregnancy body mass index,gestational age of diabetes diagnosis,triglyceride(TG),total cholesterol(TC),and insulin usage of GDM patients in the good outcome group were compared with those in the poor outcome group,the differences were statistically significant(P<0.05).Serum Resistin level in GDM patients with poor outcome was higher than that in good outcome group,and the expression level of Irisin was lower than that in good outcome group(P<0.05).Multivariate logistic regression analysis showed that gestational age,TC,Resistin and Irisin were independent influencing factors of poor postpartum blood glucose outcome in GDM patients(P<0.05).The sensitivity,specificity and area under the curve of serum Resistin and Irisin combined in predicting poor postpartum blood glucose outcome in GDM patients were 86.25%,88.35%,and 0.924.Conclusion The combined detection of Resistin and Irisin in serum of GDM patients has high diagnostic value for poor postpartum blood glucose outcome in GDM patients,and may be used as a potential marker for predicting poor postpartum blood glucose outcome in GDM patients.

Key words： Resistin Irisin gestational diabetes mellitus blood glucose outcome

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	Articles by authors
	BAI Xue
	ZHONG Hai-hua
	WANG Xiao-jie
	CHEN Pan

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BAI Xue,ZHONG Hai-hua,WANG Xiao-jie, et al. Predictive value of serum Resistin and Irisin in postpartum blood glucose outcome of gestational diabetes mellitus[J]. 中国当代医药, 2021, 28(27): 23-26.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2021/V28/I27/23

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