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2020 Vol. 27, No. 25
Published: 2020-09-08
 
 
4 Protective mechanism of Tetrandrine against hippocampus in Streptozocin induced diabetic mice
ZHANG Ru-yi; LIU Xin;CAI Fei
Objective To investigate the protective mechanism of Tetrandrine against hippocampus in Streptozocin(STZ) induced diabetic mice. Methods A total of 32 male C57 mice aged 10-12 weeks were randomly divided into four groups, 8 mice in each group, which were control group, Tetrandrine control group, model group and Tetrandrine treatment group. On the day after the establishment and administration of the diabetic model, the water maze test was used to detect the spatial learning and memory ability of the mice, the enzyme-labeled colorimetric method was used to detect the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) in the homogenate of hippocampus, the enzyme linked immunosorbent assay (ELISA) was used to detect the contents of interleukin-1β (IL-1β), interleukin-6(IL-6) and tumor necrosis factor-α (TNF-α) in hippocampal tissue homogenate. Western blotting was used to detect p-Smad2 and p-Smad3 protein expression of hippocampal tissue. Results Compared with the control group, the spatial learning and memory ability of mice in the model group decreased, and the escape latency of water maze was longer than that in the control group, and the differences were statistically significant (P＜0.05). The SOD content in the hippocampal tissue homogenate of the model group was lower than that of the control group, and the MDA content was higher than that of the control group, the differences were statistically significant (P＜0.05). The contents of IL-1β, IL-6 and TNF-α in the model group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The protein expression levels of p-Smad2 and p-Smad3 in the model group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Compared with the model group, the spatial learning and memory ability of mice in the Tetrandrine treatment group increased, and the escape latency of the water maze was shorter than that in the model group, the differences were statistically significant (P＜0.05). The SOD content in the hippocampal tissue homogenate of the Tetrandrine treatment group was higher than that of the model group, and the MDA content was lower than that of the model group, the differences were statistically significant (P＜0.05). The contents of IL-1β, IL-6 and TNF-α in the Tetrandrine treatment group were lower than those in the model group, and the differences were statistically significant (P＜0.05). The protein expression levels of p-Smad2 and p-Smad3 in the Tetrandrine treatment group were lower than those in the model group, and the differences were statistically significant (P＜0.05). Conclusion Tetrandrine can antagonize hippocampal injury in STZ induced diabetic mice, and its mechanism may be related to inhibition of oxidative stress and its downstream Smad signaling pathway.
2020 Vol. 27 (25): 4-8 [Abstract] ( 37 ) HTML (42 KB)  PDF  (0 KB)  ( 11 )
9 Effect comparison of Apatinib and Etoposide in the treatment of relapsed and refractory small cell lung cancer
SHI Ling ;WANG Zhi ;ZUO Hong-bo
Objective To compare the clinical effect of Apatinib and Etoposide in the treatment of relapsed and refractory small cell lung cancer (SCLC). Methods Ninety-eight patients with relapsed and refractory SCLC addmited to the Department of Oncology in Jiujiang No.1 People′s Hospital from January 2016 to January 2018 were selected as research objects and randomly divided into Apatinib group (52 cases) and Etoposide group (46 cases) by computer. Patients in the Apatinib group received Apatinib 500 mg/d orally, and patients in the Etoposide group received Etoposide Capsules 175 mg/d orally for 10 days, with a course of treatment every 21 days. According to RECISIT 1.1 standard,the efficacy was evaluated, including objective response rate (ORR) and disease control rate (DCR). Serum levels of neuron-specific enolase (NSE) and gastrin-releasing peptide precursor (ProGRP) were detected. The patients were followed up to calculate median progression-free survival and median overall survival. The occurrence of adverse reactions during treatment was assessed. Results The ORR and DCR of the Apatinib group were higher than those of the Etoposide group, and the differences were statistically significant (P＜0.05). Before treatment, there were no statistically significant differences in the levels of NSE and ProGRP between the two groups (P＞0.05). The NSE and ProGRP levels of the two groups after treatment were lower than those before treatment, and those in the Apatinib group were lower than those in the Etoposide group, the differences were statistically significant (P＜0.05). The median overall survival and median progression-free survival (5.2, 4.2 months) of patients in the Apatinib group were longer than those in the Etoposide group (3.9, 3.0 months), and the differences were statistically significant (P＜0.05). The incidences rates of fatigue, bone marrow suppression, gastrointestinal reactions, liver and kidney damage, and cardiotoxicity in the Apatinib group were lower than those in the Etoposide group, and the incidence rates of hypertension and proteinuria were higher than those in the Etoposide group, with statistical significances (P＜0.05). There was no statistically significant difference in the incidence of hand-foot syndrome between the two groups (P＞0.05). Conclusion Apatinib is more effective in the treatment of relapsed and refractory SCLC, and can be used as a new choice for targeted therapy for relapsed and refractory SCLC.
2020 Vol. 27 (25): 9-13 [Abstract] ( 40 ) HTML (42 KB)  PDF  (0 KB)  ( 10 )
14 Effect of hypoglycemic therapy on cardiovascular events in diabetic patients after acute myocardial infarction
WAN Wen-ting ;ZHOU Jing ;CUI Hai-ming ;QIAN Jia ;FAN Min
Objective To explore the comprehensive risk of acute myocardial infarction recurrence, congestive heart failure and death in patients with acute myocardial infarction using different options to treat diabetes. Methods A retrospective cohort study was conducted on patients with acute myocardial infarction who were hospitalized in Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine from April 1, 2015 to March 31, 2018. Among the 1432 with acute myocardial infarction, 1006 patients were without diabetes, 98 diabetic patients were without medication, 241 diabetic patients were treated with oral hypoglycemic drugs,and 87 diabetic patients were treated with insulin. A Cox proportional hazard model was established to calculate the comprehensive risk of different diabetes treatment options for the prognosis of patients with acute myocardial infarction.Results The differences in gender, hypertension, heart failure, and kidney disease between diabetic and non-diabetic patients were statistically significant (P＜0.05). After adjusting age and related factors by Cox regression, the results showed that compared with non-diabetic patients, there was a significant increase in risk among diabetic patients without medication (HR=1.37, 95%CI:1.22-1.53), diabetic patients treated with oral hypoglycemic drugs (HR=1.43,95%CI:1.31-1.56) and insulin-treated patients (HR=1.65, 95%CI:1.48-1.84). Conclusion The incidence of cardiovascular events in insulin-treated diabetic patients is higher than that in diabetic patients treated with oral hypoglycemic drugs and non-diabetic patients.
2020 Vol. 27 (25): 14-17 [Abstract] ( 33 ) HTML (37 KB)  PDF  (0 KB)  ( 11 )
18 Content determination of AE from the leaves of Actinidia eriantha Benth.and study on the extraction and purification process
Content determination of AE from the leaves of Actinidia eriantha Benth.and study on the extraction and purification process[J]. 中国当代医药, 2020,27(25): 18-22')" href="#"> WANG Yong-hong; WANG Xue-ying;PENG Shi-lu; YU Qi-nan; LI Hong-liang
Objective To establish the method for determination of 2α,3α,24-trihydroxyurs-12-en-28-oic acid (AE)from the leaves of Actinidia eriantha Benth., and optimize the extraction and purification process. Methods The content determination method of AE was established by high performance liquid chromatography-evaporative light-scattering detector (HPLC-ELSD) using AE as reference substance. The optimal extraction process was researched by single factor test and orthogonal test. The optimal purification process was researched by single factor test. Results The stable content determination method of AE was established, and it was found that the content of AE in Actinidia eriantha Benth. leaves from 5 different habitats was quite different. The optimal process of the extraction was as follows: extraction for 2 hours with 15-fold 70% ethanol in the first time, and extraction for 1 hour with 10-fold 70% ethanol in the second time. The optimal purification process was as follows: concentrating the extract to 0.50 g crude drug/ml, discarding the supernatant after sit for 8 hours, adding 30% ethanol into the sediment to let the concentration become 0.50 g crude drug/ml, and stirring thoroughly, discarding the supernatant after sit for 8 hours again, adding the appropriate amount of petroleum ether (60-90) into the sediment, and washing thoroughly. The average content of AE intermediate was 36.25%, and the yield from medicinal materials to intermediates also reached 55.96%. Conclusion The method established in this experiment is stable and feasible, and can be used for the determination of AE in Actinidia eriantha Benth. leaves, the optimized process is simple, stable and repeatable, which is suitable for industrial production.
2020 Vol. 27 (25): 18-22 [Abstract] ( 32 ) HTML (47 KB)  PDF  (0 KB)  ( 15 )
23 Research progress on the formation process of Staphylococcus aureus biofilm
GUO Qiu-ju; FENG An-ping;CHEN Kai-ming;HUANG Jian-hong
 The most common pathogens of biofilm in orthopedic department implant-related infections is Staphylococcus aureus. It is very important to study the formation process of Staphylococcus aureus biofilm for the treatment of orthopedic implant-related infections. Bacterial adhesion in host is the key first step of biofilm formation. After maturation, the physiological state of bacteria in the biofilm will change significantly. In a word, biofilm is an organism, which has complex structure and coordinating function.
2020 Vol. 27 (25): 23-26 [Abstract] ( 32 ) HTML (38 KB)  PDF  (0 KB)  ( 14 )
27 Research progress of the influencing factors and control methods for the determination of antibiotic potency by the cylinder-plate method
REN Zhong-li ;ZHANG Xiu-hua ;WANG Jing ;LI Xiu-ju ;LIU Bo
The cylinder-plate method is a commonly used method for microbiological assay of antibiotics at home and abroad. The method is classical and mature, with high sensitivity, and can directly reflect the antibacterial activity of antibiotics. This paper analyzes and summarizes the factors influencing on the assay of antibiotic microbiological by cylinder-plate method through data review and practical experience summary, and puts forward reasonable and effective solutions to reduce the errors caused by external and human factors, so that the measurement results are closer to the real value and the accuracy of the test is effectively improved.
2020 Vol. 27 (25): 27-29转33 [Abstract] ( 31 ) HTML (38 KB)  PDF  (0 KB)  ( 14 )
30 Application effect of early diet management in patients with resection of polyps under colonoscopy
CHEN Bei ;RAO Dan-xia ;LI Pei-pei
Objective To explore the application effect of early diet management in patients with resection of polyps under colonoscopy. Methods A total of 86 patients with resection of polyps under colonoscopy in the hospital from February 2018 to December 2019 were selected as the research objects, and were divided into control group and observation group by random number table method, with 43 cases in each group. The control group was given routine nursing intervention, and the observation group performed early diet management intervention on this basis. The clinically related indicators, nutritional status, complications and total nursing satisfaction of patients in the two groups were observed.Results The first defecation time, first exhaust time and hospitalization time in observation group were shorter than those in control group, the differences were statistically significant (P＜0.05). After the intervention, the levels of transferrin (TRF), hemoglobin (Hb) and plasma albumin (ALB) in two groups were higher than those before the intervention,and the TRF, Hb, and ALB levels of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). The malnutrition inflammation score (MIS) and the total incidence of complications in observation group were lower than those in control group, and the total nursing satisfaction in observation group was higher than that in control group, the differences were statistically significant (P＜0.05). Conclusion Early diet management in the intervention of patients with resection of polyps under colonoscopy can significantly improve nutritional nutritional status of patients, decrease the incidence of complications, and greatly increase nursing satisfaction of patients, which is worthy of clinical promotion.
2020 Vol. 27 (25): 30-33 [Abstract] ( 35 ) HTML (35 KB)  PDF  (0 KB)  ( 15 )
34 Clinical application value of Banxia Baizhu Tianma Decoction combined with Edaravone in the treatment of acute ischemic stroke
YE Zeng-yan
Objective To investigate the effect of applying Banxia Baizhu Tianma Decoction combined with Edaravone in the treatment of patients with acute ischemic stroke. Methods A total of 82 patients with acute ischemic stroke who were treated in our hospital from December 2018 to December 2019 were selected as the research objects. They were randomly divided into two groups, 41 cases in each group. The control group was treated with Edaravone, and the experimental group was treated with Banxia Baizhu Tianma Decoction combined with Edaravone. The scores of neurological deficits, activities of daily living and clinical efficacy were compared between the two groups. Results After treatment, the scores of neurological deficits in the experimental group was lower than that in the control group, the scores of activities of daily living and the total effective rate of treatment were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Banxiabaizhu Tianma Decoction combined with Edaravone has a definite effect in the treatment of patients with acute ischemic stroke, which can effectively improve neurological function and ability of daily living, which is worthy of clinical application.
2020 Vol. 27 (25): 34-36 [Abstract] ( 36 ) HTML (32 KB)  PDF  (0 KB)  ( 14 )
37 Clinical effect of Tiotropium Bromide Inhalation combined with Glucocorticoid in the treatment of chronic obstructive pulmonary emphysema
ZHAO Nan
Objective To explore the clinical effect of Tiotropium Bromide Inhalation combined with Glucocorticoid in the treatment of chronic obstructive pulmonary emphysema. Methods According to the order of visits, 94 patients with chronic obstructive pulmonary emphysema admitted to our hospital from October 2017 to August 2019 were randomly divided into observation group and control group, 47 cases in each group. The observation group were treated with Tiotropium Bromide Inhalation combined with Glucocorticoid, and the control group were treated with Tiotropium Bromide Inhalation only. The total effective rate of drug treatment, the improvement of pulmonary function indicators before and after treatment, blood gas indicators, 6-minute walking distance (6MWD) and the total incidence of drug adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 93.62%, which was higher than that in the control group of 76.60%, the difference was statistically significant (P＜0.05). After treatment, the levels of forced vital capacity (FVC), forced expiraton volumone second (FEV1),FEV1/FVC and maximum ventilation (MVV) of patients of the two groups were higher than those of the group before treatment, the differences were statistically significant (P＜0.05); the FVC, FEV1, FEV1/FVC and MVV levels of the observation group after treatment were higher than those of the control group, and the differences were statistically significant (P＜0.05). The partial pressure of blood oxygen (PaO2) of the observation group was higher than that of the control group, the partial pressure of blood carbon dioxide (PaCO2) was lower than that of the control group, and the 6MWD was longer than that of the control group, the differences were statistically significant (P＜0.05). The total incidence of drug adverse reactions in the observation group was 8.51%, which was lower than that in the control group of 23.40%, the difference was statistically significant (P＜0.05). Conclusion Tiotropium Bromide Inhalation combined with Glucocorticoid in the treatment of chronic obstructive pulmonary emphysema can improve the clinical treatment efficiency of patients, improve the pulmonary function and blood gas indicators of patients, improve the exercise tolerance of patients,and reduce the incidence of drug adverse reactions.
2020 Vol. 27 (25): 37-39转43 [Abstract] ( 27 ) HTML (37 KB)  PDF  (0 KB)  ( 12 )
40 Clinical effect of electromyography biofeedback combined with electroacupuncture and acupoint injection in the treatment of traumatic ulnar nerve injury
CHEN Shi-bing ;ZHU Ju-qing ;LI Zhao-hui ;LIU Ai-jing ;HUANG Shao-na
Objective To explore the clinical effect of electromyography biofeedback combined with electroacupuncture and acupoint injection in the treatment of traumatic ulnar nerve injury. Methods A retrospective analysis of 52 patients with traumatic ulnar nerve injury admitted to our department from January 2016 to August 2019 was made. They were divided into observation group and control group according to different treatment methods, with 26 cases in each group.The control group was treated with Mecobalamin Tablets orally, neuromuscular electrical stimulation, exercise therapy,electroacupuncture and acupoint injection alternately, the observation group was treated with electromyography biofeedback on this basis. After 3 course (60 days) of treatment, the shape of the hands, total active movement (TAM), and sensory recovery of patients were compared in the two groups and electrophysiological indicators such as nerve conduction velocity and wave amplitude of the affected ulnar nerve were measured. Results After treatment, the excellent and good rate in the observation group (84.62%) was higher than that in the control group (57.69%), the difference was statistically significant (P＜0.05). Before treatment, there were no significant differences in nerve conduction velocity and wave amplitude of patients between the two groups (P＞0.05); after treatment, the nerve conduction velocity and wave amplitude of patients of the two groups were higher than those before treatment, and the nerve conduction velocity and wave amplitude of the observation group after treatment were higher than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Electromyography biofeedback combined with electroacupuncture and acupoint injection in the treatment of traumatic ulnar nerve injury has a good synergistic effect, which can promote the recovery of morphology and function after traumatic ulnar nerve injury.
2020 Vol. 27 (25): 40-43 [Abstract] ( 37 ) HTML (37 KB)  PDF  (0 KB)  ( 15 )
44 Influence of cognitive behavioral intervention on mental health and quality of life in patients after permanent pacemaker implantation
PENG Min-an ;LIU Chuan-yin ;WAN Feng-fu ;WANG Xue-qiao ;YI Zhi-qiang ;LIU Duan-fu ;KUANG Linhua ;TIAN Ze-hong
Objective To explore the influence of cognitive behavior intervention on the mental health and quality of life of patients after permanent pacemaker implantation. Methods A total of 97 patients with permanent pacemaker implantation who were treated in our hospital from February 2014 to June 2018 were selected as the research subjects.They were randomly divided into the experimental group (49 cases) and the control group (48 cases) according to the lottery method. The control group used conventional health education method, and the experimental group used cognitive behavioral intervention method. The international standard anxiety scale (SAS) scores, self-anxiety scale (SDS)scores and the total scores of quality of life scale (SF-36) were compared between the two groups. Results There was no significant difference in the SAS scores between the two groups before surgery (P＞0.05). The SAS scores at 1, 3, 6 months after surgery in the experimental group were lower than those in the control group (P＜0.05). There was no significant difference in the SDS scores between the two groups before surgery (P＞0.05). The SDS scores at 1, 3, 6 months after surgery in the experimental group were lower than those in the control group (P＜0.05). There was no significant difference in the total score of SF-36 between the two groups before surgery (P＜0.05). The total scores of SF-36 at 1,3, 6 months after surgery in the experimental group were higher than those in the control group (P＜0.05). The SDS scores and SAS scores of the two groups at 1, 3, 6 months after surgery were lower than those before surgery, and the total SF-36 scores of the two groups at 1, 3, 6 months after surgery were higher than those before surgery (P＜0.05).Conclusion Cognitive-behavioral intervention can significantly improve the mental health and quality of life of patients after pacemaker implantation, and is worthy of clinical promotion.
2020 Vol. 27 (25): 44-46 [Abstract] ( 37 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
47 Application effect of remote electrocardiogram diagnosis system in basic medical institutions
DAI Shao-hua ;CHEN Hui-yan ;CHEN Yi-ying ;CHEN Hao-gang; LIANG Cui-juan
Objective To explore the application effect of remote electrocardiogram (ECG) diagnosis system in basic medical institutions. Methods From September 2018 to August 2019, 500 patients with cardiovascular disease underwent ECG examination in a community hospital of Zhaoqing city, they were examined with routine ECG and remote ECG diagnosis system. The detection rate of arrhythmia, the time from the beginning of applying for ECG examination by clinicians to the end of ECG examination report (referred to as "examination time") and diagnosis results were compared between the two methods. Results The detection rate of arrhythmia in the remote ECG diagnosis system was higher than that in the routine ECG examination, the difference was statistically significant (P＜0.05). The examination time in the remote ECG diagnosis system was shorter than that in the routine ECG examination, the difference was statistically significant (P＜0.05). The heart rate, P wave amplitude and QRS wave width of ECG waveform in lead Ⅱof remote ECG diagnosis system were lower than those of routine ECG, the differences were statistically significant (P＜0.05). The heart rate, P wave amplitude and QRS wave amplitude of ECG waveform in lead Ⅴof remote ECG diagnosis system were lower than those of routine ECG, the differences were statistically significant (P＜0.05). Conclusion Compared with routine ECG examination, remote ECG diagnosis system can detect arrhythmia better, and has the advantage of short examination time, which is convenient for community patients to carry out ECG examination and diagnosis and treatment.
2020 Vol. 27 (25): 47-49转56 [Abstract] ( 36 ) HTML (33 KB)  PDF  (0 KB)  ( 18 )
50 Effect of Amiodarone combined with Metoprolol in the treatment of arrhythmia of coronary heart disease
ZHAO Jing-hui ;WU Wei ;WANG Xiao-ping
Objective To investigate the effect of Amiodarone combined with Metoprolol in the treatment of arrhythmia of coronary heart disease. Methods A total of 100 patients with arrhythmia of coronary heart disease admitted to our hospital from January 2018 to December 2019 were selected as the study objects. According to the random envelope method, they were divided into the control group (50 cases) and the experimental group (50 cases). The control group was treated with Amiodarone, and the experimental group was treated with Amiodarone and Metoprolol. The blood pressure, premature contraction and the total effective rate of clinical treatment were compared between the two groups.Results There were no significant differences between the two groups in blood pressure changes and premature contractions before treatment (P＞0.05). The systolic blood pressure and diastolic blood pressure after treatment in the two groups were lower than those before treatment, the differences were statistically significant (P＜0.05). After treatment,the systolic and diastolic blood pressure in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). The number of ventricular premature contraction and atrial premature contraction in the experimental group were less than those in the control group, the differences were statistically significant (P＜0.05). The total effective rate of the experimental group was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Amiodarone combined with Metoprolol in the treatment of arrhythmia of coronary heart disease can improve blood pressure, reduce the incidence of ventricular premature beats and atrial premature beats, and promote the total effective rate of clinical treatment.
2020 Vol. 27 (25): 50-52转60 [Abstract] ( 35 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
53 Effect of computerized cognitive remediation therapy on the prognosis of patients with first-episode schizophrenia
LIAO Bo; LI Yan GAO Rong ;ZOU Guo-guo ;ZHAI Shao-zheng; LIU Shi-zhong ;CAO Jie ;CHEN Ming
Objective To investigate the effect of computerized cognitive remediation therapy (CCRT) on the prognosis of patients with first-episode schizophrenia. Methods A total of 80 first-episode schizophrenia patients addmited to our hospital from January to June 2018 were selected and divided into two groups according to the random number table method, with 40 cases in each group. Patients in the control group were treated with standardized antipsychotic treatment, rehabilitation treatment for common work and entertainment, and psychological treatment. Patients in the experimental group were treated with CCRT treatment on the basis of the treatment of the control group. The mental symptom relief, cognitive defect recovery and stigma change of the two groups were compared. Results There were no statistically significant differences between the positive and negative symptom scale (PANSS) scores of the two groups before treatment and at 3 months after treatment (P＞0.05). The PANSS score of the experimental group was lower than that of the control group at 6 months after treatment, and the difference was statistically significant (P＜0.05). The PANSS scores of the two groups at 3 and 6 months after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in rBANS score between the two groups before treatment (P＞0.05). The immediate memory, visual span, verbal function, attention, delayed memory scores and rBANS total score of patients in the experimental group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The immediate memory, visual span, verbal function, attention, delayed memory scores and rBANS total score of the two groups at 3 and 6 months after treatment were higher than those before treatment, and the differences were statistically significant (P＜0.05). There was no statistically significant difference in stigma score between the two groups before treatment (P＞0.05). The stigma scores of the experimental group at 3 and 6 months after treatment were lower than those of the control group, and the differences were statistically significant (P＜0.05). Stigma score in the two groups at 3 and 6 months after treatment were lower than those before treatment,and the differences were statistically significant (P＜0.05). Conclusion Computerized cognitive remediation therapy for first-episode schizophrenia can significantly improve the cognitive defects of patients, effectively reduce stigma, and promote the remission of psychiatric symptoms in the process of rehabilitation.
2020 Vol. 27 (25): 53-56 [Abstract] ( 37 ) HTML (36 KB)  PDF  (0 KB)  ( 15 )
57 Effect of peer support rehabilitation intervention on life self-care and social function in schizophrenia patients
ZHAO Ting-ting ;NIE Chun-lian ;JIANG Fang
Objective To explore the influence of peer support rehabilitation intervention on the ability of life self-care and social function of schizophrenics. Methods A total of 82 patients with schizophrenia admitted to our hospital from March 2018 to October 2019 were selected as the research objects and divided into the intervention group (41 cases)and the control group (41 cases) according to random number table method. In the control group, there was 25 cases in type Ⅰ, 16 cases in type Ⅱ. In the intervention group, there was 26 cases in type Ⅰ, 15 cases in type Ⅱ. Patients in the control group received routine antipsychotic drugs, supportive psychotherapy and general health education. Patients in the intervention group received peer support rehabilitation intervention on the basis of thecontrol group. The changes of life self-care ability and social function were compared. Results There were no statistically significant differences in activity of daily life scale (ADL) scores of type Ⅰand Ⅱpatients between the two groups before intervention (P＞0.05).The ADL scores of type Ⅰand Ⅱpatients of the two groups after intervention were lower than those before intervention, and the differences were statistically significant (P＜0.05). The ADL scores of type Ⅰand Ⅱpatients of intervention group after intervention were lower than those of the control group, and the differences were statistically significant(P＜0.05). There were no statistically significant differences between the two groups in personal and social performance scale (PSP) scores of type Ⅰand Ⅱpatients before intervention (P＞0.05). The scores of PSP of type Ⅰand Ⅱpatients in the two groups after intervention were higher than those before intervention, and the differences were statistically significant (P＜0.05). The PSP scores of type Ⅰand Ⅱpatients of the intervention group after intervention were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Peer support rehabilitation intervention can effectively improve the ability of life self-care of patients with schizophrenia, optimize their social functions and has a good effect. It is worthy of clinical application.
2020 Vol. 27 (25): 57-60 [Abstract] ( 35 ) HTML (36 KB)  PDF  (0 KB)  ( 12 )
61 Clinical effect of acupuncture combined with fastigial nucleus stimulation in patients with vascular cognitive impairment
CAO Zhong-yao
Objective To observe the clinical effect of acupuncture combined with fastigial nucleus stimulation (FNS)in patients with vascular cognitive impairment (VCI). Methods A total of 92 patients with VCI treated in our hospital during January 1, 2018 to December 31, 2019 were selected as the study subjects, and divided into observation group(30 cases, given acupuncture combined with FNS treatment), control group A (31 cases, given acupuncture treatment)and control group B(31 cases,given FNS treatment)according to the random number table method. The Montreal assessment scale (MoCA) and Lovingston assessment scale (LOTCA) were observed and the therapeutic effect was compared.Results The MoCA score and LOTCA score of the three groups were higher than those before treatment, and the differences were statistically significant (P＜0.05). The MoCA score and LOTCA score of the observation group after treatment were higher than those of the control group A and the control group B, and the differences were statistically significant(P＜0.05). There were no statistically significant differences in the MoCA score and LOTCA score between the control group A and the control group B after treatment (P＞0.05). The total effective rate in the observation group (80.00%) was higher than that in the control group A (64.52%) and the control group B (61.29%), and the differences were statistically significant (P＜0.05). There was no difference in total effective rate between control group A and control group B (P＞0.05). Conclusion Acupuncture, FNS and acupuncture combined with FNS can improve cognitive function in patients with VCI, while acupuncture combined with FNS is more effective and worthy of clinical application
2020 Vol. 27 (25): 61-64 [Abstract] ( 32 ) HTML (39 KB)  PDF  (0 KB)  ( 12 )
65 Effect of modified percutaneous tracheostomy on the surgical index, early consciousness level and quality of life in patients with severe cerebral hemorrhage and coma
LI Bao-jia;SUN Xin-lin;MO Quan; LAI Wei-feng; ZHOU Xiu-chuan
Objective To explore the effect of modified percutaneous tracheostomy on the surgical index, early consciousness level and quality of life in patients with severe cerebral hemorrhage and coma. Methods A total of 140 patients with severe cerebral hemorrhage and coma treated in the Department of Neurosurgery, People′s Hospital of Huaiji County in Zhaoqing City, Guangdong Province from January 2016 to February 2020 were selected as the research objects, and divided into control group and study group by random number table method, with 70 cases in each group.The patients in control group underwent conventional tracheostomy, and the study group underwent modified percutaneous tracheostomy. The bispectral index (BIS) and Glasgow coma scale (GCS) were used to assess the level of early consciousness, and the short-form 36 item health survey questionnaire (SF-36) was used to assess the quality of life.Followed up for 3 months, the surgery-related indicators, early consciousness level, and quality of life changes before and after 3 months of operation between the two groups were compared. Results The incision size of the study group was smaller than that of the control group, the operation time was shorter than that of the control group, the intraoperative blood loss and propofol usage were lesser than those of the control group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in the postoperative BISmean and GCSmean between the study group and the control group (P＞0.05).The postoperative BISmax of the study group was lower than that in the control group, and the BISmin was higher than that in the control group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in physiological function, psychological function, cognitive function, emotional function, role function, and total quality of life scores between the two groups before operation (P＞0.05). Postoperative 3 months, the physiological function, psychological function, cognitive function, emotional function, role function, the total quality of life scores were higher than those preoperative, and the differences were statistically significant (P＜0.05). Postoperative 3 months,the physiological function, psychological function, cognitive function, emotional function, role function, the total quality of life scores of the study group were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Compared with conventional tracheotomy, modified percutaneous tracheostomy has a shorter operation time, smaller incision, less intraoperative blood loss, and less anesthetic use, which can effectively improve the early consciousness of patients with severe cerebral hemorrhage and coma, and improve the quality of life.
2020 Vol. 27 (25): 65-69 [Abstract] ( 41 ) HTML (44 KB)  PDF  (0 KB)  ( 16 )
70 Effect of self-role recognition nursing on mental status, social skills and quality of life of female patients with schizophrenia
ZHOU Xin-ying; ZHOU Wen-qin; CAO Bo ;LIU Shu-hong ;ZHENG Gui-qin
Objective To explore the effects of self-role recognition nursing on mental status, social skills and quality of life of female patients with schizophrenia. Methods Eighty female patients with schizophrenia who were admitted to psychiatry department of the hospital from June 2015 to June 2018 were selected and divided into observation group and control group by the random number table method, 40 cases in each group. All subjects were treated with the same drugs and other symptomatic treatments. On this basis, the patients in control group were given routine nursing, the patients in observation group were given self-role recognition nursing. After 3 months of intervention, the improvement of mental status, social skills and quality of life were compared between the two groups. Results After intervention, the positive and negative syndrome scale (PANSS) scores of both groups were lower than before intervention, while the scale of social function in psychosis inpatients (SSPI) scores were higher than befor intervention, the differences were statistically significant (P＜0.05); the PANSS score of observation group after intervention was lower than that of the control group, while the SSPI score was higher than that of the control group, the differences were statistically significant (P＜0.05). After intervention, scores of all dimensions in the short-form 36 item health survey questionnaire (SF-36) of both groups were higher than before intervention, and the SF-36 scores of observation groups were higher than those of control group, the differences were statistically significant (P＜0.05). Conclusion Self-recognition nursing can significantly improve the mental state of female patients with schizophrenia, improve their social skills and quality of life, and accelerate the recovery of patients. It has high clinical promotion value.
2020 Vol. 27 (25): 70-73 [Abstract] ( 40 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
74 Clinical effect comparison of Amisulpride and Risperidone in the treatment of male schizophrenia patients
CHANG Feng-kun ;HONG Er-lang; LI Gui-lan; LI De-sheng ;GAO Hai-long
Objective To investigate the clinical effect of Amisulpride and Risperidone in male schizophrenia patients.Methods A total of 84 male schizophrenia patients admitted to our hospital from January 2018 to March 2019 were selected as subjects, and divided into the control group (42 cases) and the study group (42 cases) according to the blinded method. The control group was treated with Risperidone, while the study group was treated with Amisulpride. The symptom scores, total effective rate, adverse event rate, emotional situation and quality of life were compared. Results There were no statistically significant differences between the positive syndrome scale score, negative syndrome scale score, psychopathological scale score, positive and negative syndrome scale (PANSS) total score of the two groups before treatment (P＞0.05). The positive syndrome scale score, negative syndrome scale score, psychopathological scale score, and PANSS total score of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The positive syndrome scale score, negative syndrome scale score, psychopathological scale score, and PANSS total score of the study group after treatment were lower than those in the control group, and the differences were statistically significant (P ＜0.05). The total effective rate in the study group(92.86%) was higher than that in the control group (78.57%), and the difference was statistically significant (P＜0.05).The overall incidence rate of adverse reactions in the study group (9.52%) was lower than that in the control group(23.81%), and the difference was statistically significant (P＜0.05). There were no statistically significant differences between the self-rating anxiety scale (SAS) and the selfrating depression scale (SDS) of the two groups before treatment (P＞0.05). The SAS and SDS scores of the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P＜0.05). The SAS and SDS scores of the study group after treatment were lower than those in the control group, and the differences were statistically significant (P＜0.05). There was no statistically significant difference of the quality of life score between the two groups before treatment (P＞0.05). The quality of life scores of the two groups after treatment were higher than those before treatment, and the differences were statistically significant (P＜0.05). The quality of life scores of the study group after treatment was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Amisulpride can improve the therapeutic effect and the quality of life, effectively control the disease, relieve the disease symptoms, reduce the incidence rate of adverse reactions and promote the fast recovery.
2020 Vol. 27 (25): 74-77 [Abstract] ( 36 ) HTML (38 KB)  PDF  (0 KB)  ( 12 )
78 Application of 24 h Dynamic EEG Examination in Epilepsy Patients
XU Qi-feng;LIU Hua-qin;TAN Hong-yu
Objective To explore the application of 24 h dynamic electroencephalogram examination in epileptic patients. Methods Retrospective analysis of clinical data of 70 patients with epilepsy (Epilepsy group) treated in our hospital from January 2014 to December 2018, a 24 hour ambulatory electroencephalogram (AEEG) examination and a conventional electroencephalogram (REEG) examination were performed respectively. At the same time, 70 non-epileptic patients were used as a control group. The results of REEG and AEEG were compared, and the AEEG results were compared between the epilepsy patients and the control group. Results The normal rate of AEEG examination was lower than that of REEG examination, and the epileptiform discharge rate and total REEG abnormality rate were higher than those of REEG examination, and the differences were statistically significant (P＜0.05); there was no statistically significant difference in the non-specific discharge rate between AEEG and REEG examination (P＞0.05). The normal rate of epilepsy group examined by AEEG was lower than that of the control group, and the epileptiform discharge rate and total abnormal rate were higher than those of the control group, the differences were statistically significant (P＜0.05); there was no statistically significant difference in the non-specific discharge rate between the control group and the epilepsy group (P＞0.05). Among all the 70 patients, a total of 39 cases (55.71%) of epileptic discharge were detected, among them, 4 cases (5.71%) appeared alone when awake, 11 cases (15.71%) appeared alone during sleep, and 24 cases (34.29%) appeared during both wakefulness and sleep, epileptic discharge rate was lower in awake than in sleep(P＜0.05). Conclusion AEEG has a better effect in dynamic monitoring and diagnosis of epilepsy patients. It can record the changes of eeg in patients under different states, which is helpful to improve the clinical diagnosis rate and reduce the rate of missed diagnosis. It is also convenient to carry and non-invasive, and has positive clinical significance.
2020 Vol. 27 (25): 78-80 [Abstract] ( 32 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
81 Effect and safety of Tirofiban combined with Butylphthalide in the treatment of progressive ischemic stroke
WEN Wei-wei;ZHANG Zhi-cheng
Objective To explore the effect and safety of Tirofiban combined with Butylphthalide in the treatment of progressive ischemic stroke (PIS). Methods From January 2018 to May 2019, a total of 81 patients with PIS admitted to the Fifth People′s Hospital of Shenyang City were selected as the research objects. They were divided into control group (40 cases) and treatment group (41 cases) according to the random number table method. Patients in the control group were treated with Butylphthalide, while patients in the treatment group were treated with Tirofiban combined with Butylphthalide. The National Institutes of Health Stroke scale (NIHSS) score, daily life ability rating scale (Barthel)score before and after treatment, total therapeutic efficiency and adverse reactions of the two groups were compared.Results The NIHSS scores of the treatment group after treatment was lower than that in the control group, the BI score was higher than that in the control group, and the differences were statistically significant (P＜0.05). The total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P＜0.05). No serious adverse reactions occurred in both groups. Conclusion The application of Tirofiban combined with Butylphthalide in the treatment of PIS has clear effect, high safety, and potential clinical application value.
2020 Vol. 27 (25): 81-83转87 [Abstract] ( 31 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
84 Effect of gender and abnormal blood glucose on cognitive function with schizophrenia patients
LING Han;DENG You-mei;WANG Fu-rui
Objective To investigate the effect of gender and abnormal blood glucose on cognitive function with schizophrenia patients. Methods A total of 100 cases schizophrenia patients were collected from April 2018 to April 2019 in our hospital, according to whether combined type 2 diabetes mellitus ,they were divided into with diabetes mellitus group (50 cases, 28 cases men, 22 cases were women) and simple group (50 cases, 30 cases men, 20 cases were women). The levels of low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C),glycosylated hemoglobin (HbA1c) and fasting blood glucose (FPG) were compared between the two groups. A repetitive set of neuropsychological status tests was used to assess the patients′ cognitive function. Results There were no significant differences in LDL-C and HDL-C between the two groups (P＞0.05); the levels of FPG and HbA1c in men and women in the group with diabetes were respectively higher than those of the men and women in the simple group, with statistically significant differences (P＜0.05); the levels of FPG and HbA1c of men in the group with diabetes were increased than those of the women in the same group, with statistically significant differences (P＜0.05); the delay memory attention language visual span and immediate memory score of men in the group with diabetes were lower than those of the men in the simple group, with statistically significant differences (P＜0.05); the attention and immediate memory of women in the group with diabetes were lower than those of the women in the simple group, with statistically significant differences (P＜0.05); the cognitive function scores of the men in the group with diabetes were lower than those of the women in the same group, with statistically significant differences (P＜0.05); the visual span and immediate memory scores of the men in simple group were lower than those of the women in the same group,with statistically significant differences (P＜0.05); Spearman correlation showed that fasting blood glucose was negatively correlated with attention in male schizophrenic patients with diabetes, with statistically significant difference (r=-0.32, P=0.000); but there were no correlations between the delayed recall memory, language, visual span, immediate memory and the FPG (P＞0.05); There were no correlations between the FPG of the women schizophrenic patients with diabetes and the delayed recall memory, attention, language, visual span, immediate memory (P＞0.05). Conclusion Patients with abnormal blood glucose may aggravate the cognitive impairment in schizophrenics, especially in men.
2020 Vol. 27 (25): 84-87 [Abstract] ( 36 ) HTML (36 KB)  PDF  (0 KB)  ( 11 )
88 Application of enhanced recovery after surgery concept in the perioperative period of elderly total knee arthroplasty
LI Yong-ning;ZHANG Chen; WANG Jian-xiong;CHEN De-sheng
Objective To explore the application of enhanced recovery after surgery (ERAS) concept in the perioperative period of elderly total knee arthroplasty. Methods A retrospective analysis was proformed on 96 elderly patients who underwent artificial total knee arthroplasty for knee osteoarthritis from August 2018 to August 2019 in the General Hospital of Ningxia Medical University. The 46 patients who had not uesd ERAS were taken as in the control group,50 patients who used the ERAS concept-related method during in the perioperative period was taken as in the experimental group. All the patients′s data were completely followed up, the operation time, intraoperative blood loss, hospitalization time,postoperative complications,knee hospital for special surgery(HSS)score and visual analogue scale(VAS)score were observed in the two groups. Results There were no significant differences in the operation time, intraoperative bleeding, and incision healing time between the two groups (P＞0.05). The hospitalization time in the experimental group was shorter than that in the control group, the VAS scores at 1 day and 1 week after surgery and the total incidence of postoperative complications were lower than those in the control group, the HSS scores at 1 week, 1 month and 3 months after surgery were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The application of ERAS in the perioperative period of total knee arthroplasty in the elderly has little effect on the operation time, intraoperative bleeding and other therapeutic effects, but it has a significant impact on the postoperative joint rehabilitation effect, which can accelerate the recovery of postoperative knee joint mobility and reduce postoperative complications, improve knee joint function, faster postoperative recovery, shorter hospitalization time, and enable patients to achieve greater clinical efficacy during the perioperative period.
2020 Vol. 27 (25): 88-91 [Abstract] ( 32 ) HTML (39 KB)  PDF  (0 KB)  ( 14 )
92 Clinical effect of digital orthopedics 3D reconstruction technology assisted hollow compression screw internal fixation in treatment of Garden Ⅰ-Ⅱfemoral neck fracture
LU Dong-yan; ZENG Mian-dong ;YANG Bo; HU Han-sheng ;LI Yuan-hui ;YIN De-long ;QIU Qin-ye
Objective To investigate the clinical effect of digital orthopedics 3D reconstruction technology assisted hollow compression screw internal fixation in treatment of GardenⅠ-Ⅱfemoral neck fractures; Methods A retrospective analysis of 44 patients with GardenⅠ-Ⅱfemoral neck fractures admitted to our hospital from June 2011 to June 2019 was made. They were divided into control group and observation group according to different surgical schemes. The 22 cases in the control group were treated with internal fixation with hollow compression screws for femoral neck fracture after conventional X-ray and CT reading; 22 cases in the observation group were treated before according to Mimics software, a fracture model was established, fracture fragments were segmented, surgical reduction was simulated, and 3-matic reconstruction screws were used. The optimal screw placement angle and screw length in Mimics were followed by internal compression fixation of hollow compression screws for femoral neck fractures. The operation time, total number of fluoroscopy times, total intraoperative blood loss, complete fracture healing time, postoperative weight-bearing time, and Harris hip function scores at half a year after surgery were compared between the two groups. Results The operation time of the observation group was shorter than that in the control group, and the total number of fluoroscopy times and total intraoperative blood loss were less than those in the control group, the differences were statistically significant (P＜0.05). There were no significant differences in complete fracture healing time, postoperative weightbearing time, and Harris hip function scores at half a year after surgery between the tow groups (P＞0.05). Conclusion Applying digital orthopedic 3D reconstruction technology to GardenⅠ-Ⅱfemoral neck fracture surgery, it can simulate the position of the hollow screw before operation, determine the screw type and screw length in advance, reduce the total number of fluoroscopy times, shorten the operation time, and reduce the total intraoperative blood loss and reduce the incidence of screw position misalignment.
2020 Vol. 27 (25): 92-95 [Abstract] ( 32 ) HTML (39 KB)  PDF  (0 KB)  ( 13 )
96 Clinical effect of modified Scarf osteotomy in the treatment of moderate to severe hallux valgus
LIU Zheng-yu; CUI Jun
Objective To explore the clinical effect of modified Scarf osteotomy in the treatment of moderate to severe hallux valgus. Methods A total of 80 cases with moderate to severe hallux valgus admitted to our hospital from April 2017 to February 2019 were selected as the research objects, they were divided into two groups according to the random number table method, with 40 cases in each group. The control group received traditional Scarf osteotomy, and the observation group received modified Scarf osteotomy. The classification of hallux valgus angle (HVA), the 1, 2 metatarsal angle (IMA) and the tibial sesamoid position grading were compared between the two groups of patients after surgery; the complications of the two groups were counted; follow-up for 3 months, the American Orthopaedic Foot and Ankle Score (AOFAS score) changes were counted. Results Three months after surgery, the HVA and IMA angles and classification of the tibial sesamoid position in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, the difference was statistically significant (P＜0.05). At 1 month and 3 months after surgery, the AOFAS score in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion For patients with hallux valgus deformity, the implementation of modified Scarf osteotomy can effectively improve the postoperative anatomical structure of the foot after surgery, and has fewer surgical complications, which is of great value in promoting postoperative functional recovery.
2020 Vol. 27 (25): 96-98 [Abstract] ( 29 ) HTML (34 KB)  PDF  (0 KB)  ( 18 )
99 Study on effect of PFNA internal fixation on functional recovery after internal fixation of femoral intertrochanteric fractures in elderly
CAO Tai-yang ;LUO Zhi-mei ;LIU Chuan-lin ;LIU Zhang-sheng ;HUANG Jie ;WANG Xian-fang
Objective To investigate the clinical effect of proximal femoral nail anti-rotation (PFNA) in the treatment of intertrochanteric fractures of the elderly. Methods A retrospective selection of 60 elderly patients with intertrochanteric fractures admitted to our hospital from July 2018 to December 2019 was made. According to the different research methods, they were divided into control group and study group, with 30 cases in each group. The control group was treated with locking compression plate (LCP), the study group was treated with PFNA internal fixation. The operation time, hospitalization time, clinical fracture healing time, intraoperative blood loss, Harris hip function, visual analogue scale (VAS) score and complications were observed in the two groups. Results The operation time, hospitalization time and clinical fracture healing time of the study group were shorter than those in the control group, and the amount of intraoperative blood loss was less than that in the control group, the differences were statistically significant (P＜0.05). At 2 weeks and 1 month after surgery, the Harris hip function score of the study group was higher than that of the control group, the difference was statistically significant (P＜0.05); the postoperative VAS score in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05). There was no complication in the study group, and the total complication rate in the control group was 6.67%, there was no significant difference between the two groups (P＞0.05). Conclusion PFNA internal fixation has a significant clinical effect in the treatment of femoral intertrochanteric fractures in the elderly, which can promote postoperative functional recovery, relieve pain, prevent complications, and have high clinical application value.
2020 Vol. 27 (25): 99-101转105 [Abstract] ( 29 ) HTML (34 KB)  PDF  (0 KB)  ( 14 )
102 Application effect comparison of external fixator and plaster fixation in patients with elbow joint stiffness releasing surgery
LIANG Jian-xin; GUO Jiu-sheng; LI Qi
Objective To compare the application effect of external fixator and plaster fixation in patients with elbow joint stiffness releasing surgery. Methods A total of 40 cases of elbow joint stiffness admitted to our hospital from April 2018 to April 2019 were selected as research objects. According to the random number table method, they were divided into external fixator group (n=20) and plaster fixation group (n=20), both groups were treated with the same surgical releasing method. The Amadio score, range of elbow joint motion, Mayo score, clinical treatment satisfaction, and recurrence of the two groups of patients were observed before surgery and 1 month after surgery. Results The Amadio score,range of elbow joint motion and Mayo score of patients between the two groups before surgery and 1 month after surgery had no significant differences (P＞0.05). The Amadio score, range of elbow joint motion and Mayo score of 1 month after surgery were higher than those of this group before surgery, the differences were statistically significant (P＜0.05); and the clinical treatment total satisfaction of the external fixator group was higher than that in the plaster fixation group,and the recurrence rate was lower than that in the plaster fixation group, the differences were statistically significant(P＜0.05). Conclusion Compared with plaster fixation, the external fixator has a better application effect after elbow joint stiffness releasing surgery. It can not only improve the Amadio score, range of elbow joint motion, and the Mayo score, but also increase the satisfaction of clinical treatment and reduce the recurrence rate.
2020 Vol. 27 (25): 102-105 [Abstract] ( 30 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
106
Effect comparison of posterior minimally invasive percutaneous and transforaminal approach pedicle screws in the treatment for thoracolumbar fractures
WEN Shu-rong WU Yong-hui
Effect comparison of posterior minimally invasive percutaneous and transforaminal approach pedicle screws in the treatment for thoracolumbar fractures
WEN Shu-rong WU Yong-hui
[J]. 中国当代医药, 2020,27(25): 106-108')" href="#">		 WEN Shu-rong;WU Yong-hui

Objective To compare the clinical effect of posterior minimally invasive percutaneous and transforaminal approach pedicle screws in the treatment for thoracolumbar fractures. Methods Forty patients with thoracolumbar fractures who were treated in our hospital from June to February 2018 were selected as the research objects. They were divided into a control group (20 cases) and an observation group (20 cases) according to the random number table method. The observation group received minimally invasive percutaneous pedicle screw treatment, and the control group received transmuscular pedicle screw treatment. The surgical parameters such as the height of the anterior edge of the injured vertebrae, the Cobb angle of the sagittal vertebral kyphosis and the surgical efficacy of the two groups were compared. Results The height of the anterior edge of the injured vertebrae of patients of the two groups at 1 week and 6 months after surgery was greater than that in the group before surgery, and the Cobb angle of the sagittal vertebral kyphosis was smaller than that in the group before surgery, the differences were statistically significant (P＜0.05). There were no significant differences in the height of the anterior edge of the injured vertebrae and the Cobb angle of the sagittal vertebral kyphosis between the two groups before surgery, 1 week after surgery and 6 months after surgery (P＞0.05). There was no significant difference in the total clinical efficiency of patients between the two groups (P＞0.05).Conclusion Patients with thoracolumbar fractures undergo posterior minimally invasive percutaneous and transforaminal approach pedicle screws, which have high clinical effect, and surgical treatment can be selected according to the patient′s wishes.
2020 Vol. 27 (25): 106-108 [Abstract] ( 27 ) HTML (30 KB)  PDF  (0 KB)  ( 14 )
109 Effect of mindfulness training on the pain degree and negative emotions in patients with lumbar disc herniation
GUO Shui-xia; MA Xue-hua;ZUO Hai-hua
Objective To explore the effect of mindfulness training on the pain degree and negative emotions in patients with lumbar disc herniation. Methods A total of 120 patients with lumbar disc herniation who were treated in the department of rehabilitation of our hospital from April to September 2018 were selected as the research objects. They were divided into an experimental group and a control group according to a random number table method, with 60 cases in each group. The patients in the control group received conventional nursing intervention, the experimental group received mindfulness training intervention. The back pain function index (ODI) was used to assess the degree of back pain before and after intervention in the two groups, the anxiety self-rating anxiety scale (SAS) and the depression selfassessment scale (SDS) were used to assess the patients′ negative emotions and the quality of life scale (SF-36) to assess patients′ quality of life. Results The ODI score of patients in the experimental group was (6.64±1.14) points, SDS was(42.56±8.34) points, and SAS was (42.46±7.80) points, which were lower than those of the control group of (14.27±1.07),(48.87±11.20), (47.28±8.59) points, the differences were statistically significant (P＜0.05); the SF-36 score of patients in the experimental group was higher than that in the control group, the difference was statistically significant (P＜0.05).Conclusion Mindfulness training can effectively reduce the pain and feeling of patients with lumbar disc herniation,improve patients′ negative emotions, relieve patients′ anxiety and depression, and improve patients′ quality of life.
2020 Vol. 27 (25): 109-111 [Abstract] ( 33 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
112 Significance of ultrasonic bone mineral density detection combined with Calcium nutrition guidance for the elderly pregnant women
HUANG Qin ;WANG Xin-jiang; HUANG Xiao-yun
Objective To explore the significance of ultrasound bone mineral density (BMD) detection combined with Calcium nutrition guidance for the elderly pregnant women. Methods A total of 400 cases of elderly pregnant women who established health records of pregnant women and had regular prenatal examination in our hospital from May 2017 to May 2019 were selected as the research objects. According to the random number table method, they were divided into the control group and the observation group, with 200 cases in each group. Both groups received ultrasound quantitative BMD detection at 20 weeks and 32 weeks of gestation. The control group received the guidance of routine health care knowledge during pregnancy, and the observation group received the guidance of Calcium nutrition on this basis. BMD at 20 weeks and 32 weeks of gestation and complications of mothers and infants were compared between the two groups. Results The results of BMD detection at 20 and 32 weeks of gestation in the observation group were better than those in the control group, and the differences were statistically significant (P＜0.05). The incidence of pregnancy hypertension, gastrocnemius spasm, lumbago and leg pain, pubic symphysis pain, walking difficulty, intrauterine growth restriction of fetus, and fetal skeletal malformation in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Ultrasound BMD detection combined with Calcium nutrition guidance can reduce the decrease of BMD during pregnancy, increase the content of Calcium in the mother and reduce the risk of maternal and infant complications during pregnancy, which is worthy of clinical recommendation.
2020 Vol. 27 (25): 112-114 [Abstract] ( 29 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
115 Effect of Goserelin combined with laparoscopic surgery on the levels of sex hormones and vascular -related indices in the patients with endometriosis
JIA Rui-juan ;SHUAI Jian-gang ;DONG Ju-lang
Objective To observe the effect of Goserelin combined with laparoscopic surgery on the levels of sex hormones and vascular-related indices in the patients with endometriosis (EMT). Methods A total of 92 patients with EMT who were treated in our hospital from November 2016 to October 2018 were selected and divided into two groups according to the random number table method, with 46 patients in each group. The control group was given laparoscopic surgery, and the observation group was given Goserelin combined with laparoscopic surgery. The sex hormones (follicle stimulating hormone [FSH], estradiol [E2], luteinizing hormone [LH]), vascular-related indices (angiogenin-2 [Ang-2],vascular growth factor [VEGF]), adverse reactions and recurrence rate were compared between the two groups. Results The differences of the levels of FSH, E2, LH, Ang-2 and VEGF in the two groups before treatment were not statistically significant (P＞0.05); after treatment, FSH ([3.88±0.97]mmol/L), E2 ([12.45±4.18]mmol/L), LH ([0.58±0.22]mmol/L),Ang-2 ([2.14±0.85]mg/L) and VEGF ([1.12±0.41]mg/L) in the observation group were respectively lower than those in the control group ([4.90±1.15]mmol/L, [23.14±6.79]mmol/L, [1.48±0.54]mmol/L, [3.21±1.10]mg/L, [1.81±0.65]mg/L),and the differences were statistically significant (P＜0.05); the recurrence rate in the observation group was 4.35%, lower than 19.57% in the control group, and the difference was statistically significant (P＜0.05); the difference in the total incidence rate of adverse reactions between the two groups was not statistically significant (P ＞0.05). Conclusion Goserelin combined with laparoscopic surgery in the treatment of EMT can reduce the recurrence rate, improve patients' sex hormone levels and vascular-related indices,and have fewer adverse reactions.
2020 Vol. 27 (25): 115-117 [Abstract] ( 29 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
118 Influence of spontaneous exertion in lateral position on the second stage of labor and delivery outcomes in primiparous women with epidural analgesia
KE Ying ;HUANG Ren-ying; XIAO Wen-ping
Objective To study the effect of spontaneous exertion in the lateral position on the second stage of labor and delivery outcomes in primiparous women with epidural analgesia. Methods A total of 200 primiparas from February 2019 to February 2020 in our hospital were selected as the research objects. They were divided into control group and observation group according to random number table method, 100 cases in each group. In the control group, supine position used to guide breath holding and force extension, the observation group used spontaneous exertion in the lateral position，the second stage of labor, exertion time, postpartum hemorrhage, delivery outcome, and analgesia satisfaction of the second stage of labor between the two groups were compared. Results The second labor time and exertion time in the observation group were shorter than those in the control group, and the postpartum hemorrhage in the observation group was less than that in the control group, the differences were statistically significant (P＜0.05). The delivery mode of the observation group was better than that of the control group, the difference was statistically significant(P＜0.05). The analgesia satisfaction in the second stage of the observation group was 98.0%, which was higher than that of the control groups for 87.0%, the difference was statistically significant (P＜0.05). Conclusion The use of spontaneous force in the lateral position during the epidural analgesia of primiparous women can shorten the second labor time and exertion time, reduce the amount of postpartum hemorrhage, and increase the natural labor rate and satisfaction with analgesia in the second labor. The effect is excellent.
2020 Vol. 27 (25): 118-120 [Abstract] ( 25 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
121 Application effect of Terbutaline combined with Azithromycin sequential therapy in children with pneumonia
DING Yuan-yuan
Objective To investigate the effect of Terbutaline combined with Azithromycin sequential therapy in children with pneumonia. Methods A total of 86 children with pneumonia admitted to our hospital from January 2017 to January 2019 were selected as the subjects, and they were divided into observation group and control group, with 43 cases in each group by random number table method. The control group was treated with routine medicine and Azithromycin, and the observation group was treated with Terbutaline on the basis of the control group. The changes of airway inflammatory factors (hypersensitive-C-reactive protein [hs-CRP], tumor necrosis factor-α [TNF-α]), pulmonary function [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC)]were compared between the two groups before treatment and 14 days after treatment; the time of symptom disappearance (antipyretic time, antitussive time) and hospitalization time were compared between the two groups; the adverse reactions were compared between the two groups. Results Before treatment, there were no significant differences in TNF-α and hs-CRP between the two groups (P＞0.05); after 14 days of treatment, the hs-CRP and TNF-α of children of the two groups were lower than those before treatment, and the TNF-α and hs-CRP levels of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). Before treatment, there were no significant differences in FEV1 and FVC levels between the two groups (P＞0.05); after 14 days of treatment, the FEV1 and FVC levels of the two groups of children were higher than those before treatment, and the FEV1 and FVC levels of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). The time of antipyretic, antitussive and hospitalization in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05);there was no significant difference in total adverse reactions between the two groups (P＞0.05). Conclusion Terbutaline-assisted Azithromycin sequential therapy of pediatric pneumonia can effectively reduce the level of airway inflammatory factors in children, improve the lung function of the patients, accelerate the resolution of symptoms, reduce the length of hospitalization in children, and has good safety.
2020 Vol. 27 (25): 121-123转127 [Abstract] ( 29 ) HTML (36 KB)  PDF  (0 KB)  ( 14 )
124 Application of cold knife conization, transvaginal cone-resection of cervix uteri and hysteroscopic coagulation adjuvant cold knife conization in high-grade squamous intraepithelial lesion
ZENG Qiu-ping; LI Xiao-xia ;CHEN Qiao-feng
Objective To investigate the application of cold knife conization (CKC), transvaginal cone-resection of cervix uteri (TCRC) and hysteroscopic coagulation adjuvant cold knife conization (HCKC) in high-grade squamous intraepithelial lesion(HSIL).Methods The clinical data of 118 patients with HSIL who underwent surgical treatment in our hospital from January 2016 to August 2018 were retrospectively analyzed, and they were divided into the CKC group(38 cases), the TCRC group (46 cases) and the HCKC group (32 cases) according to different surgical methods. The CKC group was treated with CKC, the TCRC group was treated with TCRC, and the HCKC group was treated with HCKC.The clinical efficacy, perioperative conditions, the coincidence rate of pathological diagnosis and the total incidence of complications were compared among the three groups. Results There were no statistically significant differences between the three groups in lesion clearance rates and length of stay (P＞0.05). The operation time of the HCKC group and the TCRC group was shorter than that of the CKC group, and the intraoperative blood loss of the HCKC group and the TCRC group was less than that of the CKC group, the differences were statistically significant (P＜0.05). There was no significant difference in hospitalization time among the three groups (P＞0.05). There was statistically significant difference among the three groups in pathological diagnosis (P＜0.05). There were no significant differences in the total incidence of postoperative bleeding, cervical stenosis, abnormal menstruation, repeated abdominal pain and other complications among the three groups (P＞0.05). Conclusion CKC, TCRC and HCKC are all effective treatment methods for HSIL patients. HCKC has the advantages of short operative time, low intraoperative blood loss and high coincidence rate of pathological diagnosis, which is worthy of further promotion.
2020 Vol. 27 (25): 124-127 [Abstract] ( 25 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
128
Application of transnasal high flow oxygen therapy in noninvasive ventilation of newborn
 
Application of transnasal high flow oxygen therapy in noninvasive ventilation of newborn
 
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Objective To discuss the effect of transnasal high flow oxygen therapy (HFNC) in noninvasive ventilation of newborn. Methods A total of 76 neonates with mechanical ventilation admitted to our hospital from February, 2015 to December 2018 were selected as subjects and divided into observation group and control group according to random number table method, 38 cases in each group. Neonates in control group were given nasal continuous positive airway pressure (NCPAP), and neonates in observation group were given HFNC. The indexes of blood gas analysis (pH, partial pressure of blood carbon dioxide [PaCO2]and oxygen [PaO2]), disappearance time of clinical symptoms and complications between two groups were compared. Results There were no significant differences in pH, PaCO2 and PaO2 between the two groups before ventilation, 24 and 72 hours after ventilation (P＞0.05). The disappearance time of dyspnea,lung rales, three concave sign and cyanosis in observation group were shorter than those in control group, the differences were significant (P＜0.05). The incidence of complications in observation group was lower than that in control group, the difference was significant significant (P＜0.05). Conclusion The effect of HFNC on neonatal noninvasive ventilation is similar to that of NCPAP, but HFNC can improve clinical symptoms and reduce complications, and the overall ventilation effect is better than that of NCPAP.
2020 Vol. 27 (25): 128-130 [Abstract] ( 25 ) HTML (35 KB)  PDF  (0 KB)  ( 13 )
131 Feasibility study of comprehensive nursing service for children with infectious diarrhea
ZHONG Wei-jian
Objective To explore the feasibility and value of comprehensive nursing services for children with infectious diarrhea. Methods A total of 100 children with infectious diarrhea who were admitted to our hospital from January 2018 to June 2019 were enrolled in the study. They were divided into the control group and the study group according to the random number table method, with 50 cases in each group. In the control group, conventional nursing was used, and in the study group, comprehensive nursing service was adopted. The total effective rate of nursing in the two groups was observed, the fever time, diarrhea time and hospital stay of children were recorded, and the nursing satisfaction of the children and their parents to clinical nursing was evaluated. Results The total effectiveness rate of nursing in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The fever time, diarrhea time, and hospital stay in the study group were shorter than those in the control group,and the differences were statistically significant (P＜0.05). The nursing satisfaction of children and parents in the study group was higher than that in the control group, with statistical significance (P＜0.05). Conclusion Comprehensive nursing can significantly improve the nursing effect of children with infectious diarrhea, shorten the time of fever, diarrhea and hospital stay, and promote the early recovery of children′s health, which is worthy of clinical promotion.
2020 Vol. 27 (25): 131-134 [Abstract] ( 24 ) HTML (37 KB)  PDF  (0 KB)  ( 15 )
135 Feasibility analysis of transvaginal delivery of scar uterine repregnancy
HUANG Wei
Objective To analyze the feasibility of transvaginal delivery of scar uterine repregnancy. Methods A total of 92 pregnant women with scarred uterus who were admitted to our hospital from October 2018 to October 2019 were selected for study, and they were divided into two groups according to the way of maternal delivery. A total of 46 women in the control group were delivered by cesarean section, and 46 women in the observation group for vaginal delivery.The maternal delivery status, newborn status, labor time, complications and other indicators were compared between the two groups. Results The postpartum hemorrhage and hospitalization expenses of the observation group were lower than those of the control group, and the hospital stay was shorter than that of the control group, the differences were statistically significant (P＜0.05). There were no statistically significant differences between the two groups of newborns in Apgar score, newborn weight, and labor (P＞0.05). The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The pregnant women with scarred uterus can choose vaginal delivery during delivery, and vaginal delivery can reduce the amount of postpartum hemorrhage, reduce the occurrence of complications, effectively shorten the recovery time, and has high application value.
2020 Vol. 27 (25): 135-137 [Abstract] ( 25 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
138 Application effect of Ropivacaine combined with Dexmedetomidine on analgesia after cesarean with abdominal transverse fascia plane block
ZHENG Wen-zhong; LI Chang-hong; YAN Xue-tao
Objective To observe the effect of Ropivacaine combined with Dexmedetomidine on analgesia after cesarean with abdominal transverse fascia plane block. Methods A total of 90 women who underwent cesarean with elective lumbar and spinal anesthesia from July 2018 to July 2019 were selected as the research objects and randomly divided into observation group and control group according to the order of admission, with 45 cases in each group. Ultrasoundguided transverse fascia plane block was performed in both groups. The women in the control group received Ropivacaine for analgesia. The women in the observation group combined with Dexmedetomidine for analgesia on the basis of the control group. The two groups both received patient controlled intravenous analgesia (PCIA). The postoperative visual analogue scale (VAS), the postoperative sedation score (Ramsay score)，the number of PCIA and the total incidence of adverse reactions within 24 hours after surgery were compared. Results The VAS scores at 8, 12 and 24 h after obstetrics in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The number of times of analgesia pump pressure at 4, 8, 12 and 24 h after obstetrics were lower than those of the control group, and the differences were statistically significant (P＜0.05). The Ramsay scores of the two groups at 8, 12 and 24 h after obstetrics were compared, and the differences were not statistically significant (P＞0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Ropivacaine combined with Dexmedetomidine for patients with abdominal transverse fascia plane block cesarean has good postoperative analgesia effect and can reduce the overall incidence of postoperative adverse reactions.
2020 Vol. 27 (25): 138-140 [Abstract] ( 28 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
141 Application of laryngeal mask general anesthesia with keeping self breathing in thoracoscopic bullectomy
LIAN Sheng-qiang;PENG Xiao-lan; JI Hao-cong
Objective To analyze and discuss the application of laryngeal mask general anesthesia with keeping self breathing in thoracoscopic bullectomy. Methods A total of 106 patients who accepted thoracoscopic bullectomy in our hospital from September 2017 to September 2019 were selected as the study objects, and they were divided into control group (53 cases) and observation group (53 cases) by "color ball grouping" method. The patients in the control group were anesthetized with muscle relaxant and double lumen bronchus catheter, while the patients in the observation group were anesthetized with keeping self breathing during laryngeal mask insertion. The operation time, wake-up time, hospitalization time, time of getting out of bed, mean arterial pressure (MAP), heart rate (HR) and complications were compared before and after intubation between the two groups. Results The operation time, wake-up time, hospitalization time and the time of getting out of bed in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). MAP and HR after intubation in both groups were lower than before intubation, and the differences were statistically significant (P＜0.05), but MAP and HR after intubation in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of laryngeal mask general anesthesia with keeping self breathing in thoracoscopic bullectomy not only can improve the operation index, but also improve MAP, HR and other indicators, and reduce the incidence of complications. It is worth popularizing.
2020 Vol. 27 (25): 141-143 [Abstract] ( 23 ) HTML (34 KB)  PDF  (0 KB)  ( 13 )
144 Diagnostic value of color Doppler ultrasound combined with multiple cutting in the diagnosis of fetal congenital heart disease
CHEN Wen-juan; ZHANG Qian
Objective To study the value of color Doppler ultrasound combined with multiple cutting in the diagnosis of fetal congenital heart disease. Methods The clinical data of 82 pregnant women with suspected fetal cardiac abnormalities from June 2017 to March 2019 were retrospectively analyzed. All pregnant women underwent color Doppler ultrasound with multiple cutting fetal heart examination. Follow-up to the end of pregnancy, using the results of neonatal cardiac examination, stillbirth, or autopsy of the induced fetus as the "gold standard", the sensitivity, specificity, and accuracy of color Doppler ultrasound and color Doppler ultrasound combined multiple cutting examination in the diagnosis of fetal congenital heart disease were evaluated. Results According to the "gold standard", 34 cases of fetal congenital heart disease were confirmed, of which 27 cases were detected by color Doppler ultrasound, and 32 cases were diagnosed by combined diagnosis. The "gold standard" was based on the results of neonatal cardiac examination, stillbirth, or autopsy of the induced fetus, the diagnostic accuracy of color Doppler ultrasound combined with multiple sections was 97.56%, which was higher than 87.80% of color Doppler ultrasound, and the difference was statistically significant (χ2=5.754, P=0.016). There were no significant difference in the sensitivity and specificity of the two inspection methods (P＞0.05). There was no significant differences in missed diagnosis rate and misdiagnosis rate between color Doppler ultrasound and color Doppler ultrasound combined with multiple cutting in the diagnosis of different types of fetal congenital heart disease (P＞0.05). Conclusion The value of color Doppler ultrasound combined with multiple cutting in the diagnosis of fetal congenital heart disease is higher, which can further improve the diagnostic accuracy, and it is of great significance to improve the health of newborns and promote eugenics.
2020 Vol. 27 (25): 144-147 [Abstract] ( 28 ) HTML (35 KB)  PDF  (0 KB)  ( 13 )
148 Clinical application value of ultrasound in neonatal pulmonary diseases
CHEN Rong
Objective To explore the clinical application value of ultrasound in neonatal pulmonary diseases. Methods A total of 100 children with suspected pulmonary disease in department of neonatology in our hospital from January 2018 to January 2019 were randomly selected. All of them were given bedside pulmonary ultrasound examination and pulmonary X-ray examination. The CT examination results were taken as the "gold standard", and the examination results of the two methods were compared. Results According to the "gold standard" examination，67 children were diagnosed with pulmonary diseases. The sensitivity, specificity and accuracy of pulmonary ultrasound examination were higher than those of pulmonary X-ray examination (P＜0.05). The main characteristics of ultrasonic image were B-line, abnormal chest mode line, patchy weak echo, and air bronchogram. Conclusion Ultrasound has significant clinical application value in neonatal pulmonary diseases, and can improve the sensitivity, specificity and accuracy. It is worth promoting.
2020 Vol. 27 (25): 148-150 [Abstract] ( 29 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
151 Application value of transvaginal combined with transabdominal color Doppler ultrasound in the diagnosis of uterine horn pregnancy
ZHANG Yu-fei
Objective To explore the value of transvaginal combined with transabdominal color Doppler ultrasound in the diagnosis of uterine horn pregnancy. Methods From March 2017 to March 2019, the clinical data of 54 patients who were confirmed to have uterine horn pregnancy by follow-up or surgical pathology were selected. All patients were diagnosed by transabdominal ultrasound and transvaginal ultrasound, the data were analyzed and the pathological diagnosis results were taken as the gold standard. The diagnosis results of different diagnostic methods were analyzed, and the results of pathological diagnosis, transabdominal color Doppler ultrasound and transvaginal color Doppler ultrasound were compared, and the application of the two diagnostic methods in the diagnosis of uterine horn was also compared.Results The specificity, accuracy and sensitivity of transvaginal color Doppler ultrasound were higher than those of transabdominal color Doppler ultrasound (P＜0.05), and the specificity, accuracy and sensitivity of combined diagnosis were higher than those of transvaginal Doppler ultrasound and transabdominal Doppler ultrasound (P＜0.05). Conclusion In the diagnosis of uterine horn pregnancy, transvaginal and transabdominal color Doppler ultrasound diagnosis can play an important role. The combined diagnosis of the two diagnostic methods has good specificity, accuracy and sensitivity, and can provide more effective theoretical basis for clinical treatment of patients, with very high clinical application value, which is conducive to the improvement of treatment efficiency and is worthy of promotion and application.
2020 Vol. 27 (25): 151-153 [Abstract] ( 25 ) HTML (30 KB)  PDF  (0 KB)  ( 15 )
154 Professor Zhang Yu-qin′s experience in treating Xiaoke with classical formulas
WANG Yao ;ZHANG Yu-qin
Xiaoke is first recorded in the Yellow Emperor′s Canon of Internal Medicine (Huangdi Neijing). Zhang Zhong-jing narrates a lot on Xiaoke in Treatise on Cold Damage (Shanghanlun) and Essentials from the Golden Cabinet(Jingui Yaolue), which records the etiology and pathogenesis of Xiaoke, as well as formulas in treating Xiaoke and its transmuted patterns. He had laid a theoretical foundation for the treatment of Xiaoke and its transmuated patterns for later generations, and had provided many effective formulas. Professor Zhang Yu-qin has been engaged in the treatment of Xiaoke for many years, through reading the classics, she can flexibly apply it to clinical practice, and is good at using classical formulas to treat Xiaoke and its transmuted patterns. For these conditions, professor Zhang commonly uses White Tiger Plus Ginseng Decoction (Baihu and Renshen Decoction), Wumei Pills, Five Substances Powder with Poria(Wuling Powder), and Astragalus and Cinnamon Twig Five Substances Decoction (Huangqi Guizhi Wuwu Decoction),which has achieved great clinical effect. In this paper, above-mentioned formulas in pattern differentiation were analyzed.
2020 Vol. 27 (25): 154-157 [Abstract] ( 25 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
158 Effect of Qixia Zhihuang Decoction in the treatment of chronic renal failure and its influence on serum homocysteine and high-sensitivity C-reactive protein levels
WANG Chao; JIANG Li-li;SHI Li-li; QIAN Hui
Objective To investigate the effect of Qixia Zhihuang Decoction in the treatment of chronic renal failure and its influence on serum homocysteine(Hcy)and high-sensitivity C-reactive protein(hs-CRP) levels. Methods A total of 92 patients with chronic renal failure who were admitted to our hospital from June 2017 to June 2019 were selected as research objects. They were divided into the observation group (46 cases) and the control group (46 cases) according to the random number table method.Both groups received conventional treatment.The control group was treated with Benazepril and Losartan on the basis of conventional regimen.The observation group was treated with Qixia Zhihuang Decoction on the treatment regimen of the control group.The serum Hcy and hs-CRP levels,renal function indexes before and after treatment and the total incidence of adverse reactions in the two groups were compared. Results The serum Hcy and hs-CRP levels of patients after treatment in the two groups were lower than those before treatment,and the above indexes of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).The serum creatinine (SCr) and urea nitrogen (BUN) of patients after treatment in the two groups were lower than those before treatment, and the above indicators in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The total incidence of adverse reactions during the treatment between the two groups was not statistically significant (P＞0.05). Conclusion Qixia Zhihuang Decoction has a good effect in the clinical treatment of patients with chronic renal failure, it can reduce their serum Hcy and hs-CRP levels, improve renal function, and does not significantly increase the incidence of adverse reactions, and has good safety.
2020 Vol. 27 (25): 158-160转164 [Abstract] ( 28 ) HTML (35 KB)  PDF  (0 KB)  ( 12 )
161 Efficacy observation of auricular point pressing beans combined with moxibustion in the treatment of postoperative pain of arteriovenous fistula
TANG Cai-feng ;WANG Xin
Objective To explore the clinical effect of auricular point pressing beans combined with moxibustion in the treatment of postoperative pain of arteriovenous fistula. Methods From March 2019 to March 2020, 72 patients with arteriovenous fistula in our hospital were selected as research objects. According to the random number table method,they were divided into the treatment group (36 cases) and the control group (36 cases). The routine postoperative nursing intervention was used in the control group on the day after operation, and the treatment group was treated with auricular point pressing beans combined with moxibustion on the day of operation on the basis of routine nursing intervention. The pain relief rate, pain score and sleep quality score after operation were compared between the two groups.Results The pain relief rate of the treatment group was 94.44%, higher than 75.00% of the control group, the difference was statistically significant (P＜0.05). There was no statistically significant difference in the numerical rating scale(NRS) score immediately after surgery between the two groups (P＞0.05). The NRS score of the patients in the treatment group was (2.31±0.69) points at 12 hours after operation, which was lower than the (3.01±1.25) points in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in sleep quality score between the two groups at 12 hours after surgery (P＞0.05). The sleep quality score of patients in the treatment group was (4.35±0.72) points after 3 days operation, which was lower than that of the control group for (6.17±0.94) points, and the difference was statistically significant (P＜0.05). Conclusion Auricular point pressing beans combined with moxibustion can effectively relieve the postoperative pain of arteriovenous fistula, NRS score is significantly reduced, patients′ sleep quality is improved, which is worth popularizing.
2020 Vol. 27 (25): 161-164 [Abstract] ( 24 ) HTML (34 KB)  PDF  (0 KB)  ( 12 )
165 Clinical effect of Yiguan therapy combined with pelvic moxibustion in the treatment of elderly constipation patients
LI Sheng-lin;KUANG Qiu-qun; ZENG Mei-hua; CHEN Ping;WU Cai-ling;WU Sui-ning;LI Bao-yu; LU Jia-yi
Objective To explore the clinical effect of Yiguan therapy combined with pelvic moxibustion in the treatment of elderly constipation patients. Methods A total of 60 patients with elderly constipation admitted to our hospital from October 2018 to October 2019 were selected as the research subjects, and they were divided into group A, group B and group C according to the random number table method, with 20 cases in each group. Group A was treated with conventional Western medicine, group B was treated with pelvic moxibustion, and group C was combined with Yiguan therapy on the basis of group B. The scores of traditional Chinese medicine (TCM) symptoms (gastric fullness, loss of appetite, fatigue and weakness), quality of life (patient assessment of constipation quality of life [PAC-QOL]), defecation function (constipation score scale [CCS]), stool traits (Bristol stool score scale) and stool frequency within 1 week were compared between the two groups before treatment and after 3 d of treatment. Results After 3 d of treatment, the scores of TCM symptoms in gastric fullness, loss of appetite and fatigue and weakness, scores of PAC-QOL and CCS in the three groups were lower than those before treatment, with statistically significant differences (P＜0.05). The scores of TCM symptoms and scores of PAC-QOL and CCS after 3 d of treatment in group B and group C were lower than those in group A, with statistically significant differences (P＜0.05). The scores of TCM symptoms and scores of PAC-QOL and CCS after 3 d of treatment in group C were lower than those in group B, with statistically significant differences(P＜0.05). The Bristol score and stool frequency within 1 week in the three groups after 3 d of treatment were higher than those before treatment, with statistically significant differences (P＜0.05). The Bristol score and stool frequency within 1 week in group B and group C after 3 d of treatment were lower than those in the group A, with statistically significant differences (P＜0.05). The Bristol score and stool frequency within 1 week in group C were higher than those in the group B, with statistically significant differences (P＜0.05). Conclusion Yiguan therapy combined with pelvic moxibustion can achieve significant effect in treating elderly constipation, alleviate the disease symptoms of patients, improve the defecation function, and promote the quality of life, traits and frequency of defecation of patients.
2020 Vol. 27 (25): 165-168转173 [Abstract] ( 26 ) HTML (43 KB)  PDF  (0 KB)  ( 12 )
169 Clinical effect of Qishi Huayu Decoction in the treatment of prolonged menstrual period in the blood stasis pattern caused by uterine incision diverticulum
LIU Cai-long;CHENG Min
Objective To observe the clinical effect of Qishi Huayu Decoction in the treatment of prolonged menstrual period in the blood stasis pattern caused by uterine incision diverticulum. Methods Totally 84 patients with prolonged menstrual period out of blood stasis caused by uterine incision diverticulum who were treated in the Clinic of Obstetrics and Gynecology, Yueyang Hospital Affiliated to Hu′nan University of Chinese Medicine were selected as the research objects. They were divided into the treatment group and the control group according to the random number table method, 42 cases in each group. The control group took Desogestrel Ethinyl Estradiol Tablets, and the treatment group added Qishi Huayu Decoction on the basis of the control group. After three menstrual cycles of treatment, the time of menstruation, the size of uterine incision diverticulum and the score of traditional Chinese medicine (TCM) syndrome before and after treatment were compared between the two groups, and the treatment effect and incidence of adverse reactions of patients were observed in the two groups. Results The time of menstruation in both groups after treatment was shorter than that before treatment, and the difference was statistically significant (P＜0.05). The width and depth of uterine incision diverticulum after treatment in both groups was smaller than that before treatment, with statistical significance (P＜0.05). The TCM syndrome scores of the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P＜0.05). The improvement of the menstruation time, width and depth of uterine incision diverticulum and TCM syndrome score after treatment in the treatment group were better than those in the control group, and the differences were statistically significant (P＜0.05). The total effective rate of treatment in the treatment group was higher than that in the control group, and the difference was statistically significant (P＜0.05). No adverse reactions occurred in the two groups. Conclusion Qishi Huayu Decoction has obvious curative effect in the treatment of prolonged menstrual period in a blood stasis pattern caused by uterine incision diverticulum. Compared with oral administration of Desogestrel Ethinyl Estradiol Tablets alone, it can better alleviate clinical symptoms and patients′ pain, which is worthy of promotion.
2020 Vol. 27 (25): 169-173 [Abstract] ( 65 ) HTML (46 KB)  PDF  (0 KB)  ( 14 )
174 Application effect of community traditimal Chinese medicine (TCM) constitution identification in the elderly health management
LYU Wei-bo;CHEN Xiao-qin;WANG Su-zhen; YU Guo-fang; CHEN Hong-ai; DENG Jia-xin
Objective To analyze the effect of community traditimal Chinese medicine (TCM) constitution identification in elderly health management. Methods From March 2018 to March 2019, 500 elderly people who received physical examination from Zancheng High-tech Zone Hospital of Foshan Traditional Chinese Medicine Hospital were divided into observation group (250 cases) and control group (250 cases) according to the parity method. The control group received traditional community nursing management, and the observation group received community TCM physical identification management. The physique score and quality of life score between the two groups were compared. Results After 3 months of management, the scores of traditimal Chinese medicine constitution and quality of life in the observation group were higher than those of the control group, and the scores of biased quality were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Community TCM constitution identification can effectively improve the constitution and quality of life of the elderly, which is worth learning.
2020 Vol. 27 (25): 174-176 [Abstract] ( 26 ) HTML (33 KB)  PDF  (0 KB)  ( 13 )
177 Effect of Mannitol combined with early Chinese medicine acupuncture on hypertensive cerebral hemorrhage
ZHONG Wen-shi ;WANG Qi-hong ;REN Xin-hai
Objective To investigate the effect of Mannitol combined with early traditional Chinese medicine acupuncture on patients with hypertensive cerebral hemorrhage. Methods A total of 60 patients with hypertensive cerebral hemorrhage diagnosed and treated in our hospital from January 2017 to May 2019 were selected as the research objects, and were divided into observation group (30 cases) and control group (30 cases) according to different treatment methods. The control group accepted Mannitol treatment, the observation group was treated with Mannitol combined with early Chinese medicine acupuncture. The clinical efficacy, limb function recovery, self-care ability and quality of life were compared between the two groups. Results The total effective rate of the observation group (96.7%) was higher than that of the control group (76.7%), and the difference was statistically significant (P＜0.05). There were no statistically significant differences in the Barthel score and FIM score between the two groups of patients before treatment(P＞0.05); Barthel score and FIM score after treatment were higher than before treatment in both groups, the differences were statistically significant (P＜0.05); after treatment, the Barthel score ([65.4±9.1]points) of the observation group was higher than that of the control group ([44.8±7.9]points), and the FIM score ([68.4±9.4]points) was higher than that of the control group ([54.4±7.5]points), the differences were statistically significant (P＜0.05); the observation group′s psychological function score ([25.5±3.8]points), social function score ([25.9±3.1]points) and physiological function score([25.1±3.2]points) were all higher than those of the control group, the differences were statistically significant (P＜0.05).Conclusion The clinical efficacy of Mannitol combined with early traditional Chinese medicine acupuncture in patients with hypertensive cerebral hemorrhage is definite, which can effectively improve the limb function and daily life ability of patients, and improve the quality of life of patients.
2020 Vol. 27 (25): 177-179 [Abstract] ( 27 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
180 Professor Chen Zhi-bin′s experience on treating chronic cough using Keping Decoction
SU Tian-sheng;LUO Ji-hong; CHEN Zhi-bin
 Chronic cough mostly belongs to "long cough" and "intractable cough" in traditional Chinese medicine.Professor Chen Zhi-bin believes that this kind of cough has a long course and often recurs. The pathogenesis is mostly deficient in root and excess in branch, to be specific, the deficiency of lung, spleen and kidney is the root, and the wind and phlegm-rheum is the branch. It can be divided into spasms due to excessive wind pattern, pathogenic wind attacking orifices pattern, turbid phlegm obstructing the lung pattern, phlegm-heat congesting the lung pattern, and liver fire invading the lung pattern. Patterns of wind-heat invading the lung and fluid damage due to lung heat are common, for this condition, professor Chen Zhi-bin created Keping Decoction to diffuse the lung, dispel wind, benefit throat and nourish fluid, which has a remarkable clinical effect.
2020 Vol. 27 (25): 180-182转186 [Abstract] ( 32 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
183 Clinical effect of acupoint massage combined with acupoint application in the treatment of cancer pain
HAN Gao ;CHEN Yan-juan
Objective To observe the clinical effect of acupoint massage combined with acupoint application in the treatment of cancer pain. Methods From January 2018 to January 2020, a total of 60 cases with cancer pain treated in our hospital were selected as the research objects. They were divided into the treatment group (30 cases) and the control group (30 cases) by the random number table method. Patients in the control group were routinely treated with Morphine Sulfate Sustained-release Tablets. On the basis of the control group, acupoint massage combined with acupoint application was added in the treatment group. Both groups were treated for 1 week. The degree of pain relief after treatment and the quality of life before and after treatment were observed and compared between the two groups. Results The total clinical effectiveness rate of pain relief in the treatment group was 93.33%, higher than that of the control group accounting for 60.00%, and the difference was statistically significant (P＜0.05). The quality of life (social status, physical status and mental status) scores had no statistical difference between the two groups before treatment(P＞0.05). The quality of life scores in the control group before and after treatment had no statistical significance (P＞0.05). After treatment, the quality of life scores in the treatment group were higher than those before treatment, and higher than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Acupoint massage combined with acupoint application in the treatment of patients with cancer pain can improve the analgesic effect and their quality of life, which is worthy of clinical promotion.
2020 Vol. 27 (25): 183-186 [Abstract] ( 22 ) HTML (37 KB)  PDF  (0 KB)  ( 13 )
187 Role of Helicobacter pylori serum antibody combined with pepsinogen detection in screening of gastric cancer and precancerous lesions
LI Yang-yang; LIN Yu-feng ;CHEN Dong-ling
Objective To investigate the role of serum Helicobacter pylori (Hp) antibody combined with pepsinogen(PG) detection in the screening of gastric cancer and precancerous lesions. Methods A total of 440 cases of patients with gastric diseases in our hospital From June 2019 to January 2020 were selected as gastric disease group, and 112 cases of healthy people in our hospital were selected as control group. The Hp infections, serum PGⅠ, PGⅡlevels and PGR of the two groups were statistically analyzed. Results Comparison of Hp positive rates and HP negative rates between gastric disease groups (gastric cancer group, gastric ulcer group, atrophic gastritis group, superficial gastritis group) and healthy control group showed no statistically significant differences (P＞0.05). The serum PGⅠlevel of patients in the gastric ulcer group was higher than that of healthy control group (P＜0.05). The serum PGⅠlevel of gastric cancer group and atrophic gastritis group was lower than that of the healthy control group (P＜0.05). The serum PGⅡlevel of gastric cancer group, gastric ulcer group and atrophic gastritis group was higher than that of healthy control group, while the PGR level was lower than that of healthy control group (P＜0.05). There were no significant differences in serum PGⅠ, PGⅡlevels and PGR between the superficial gastritis group and the healthy control group (P＞0.05).There were no statistically significant differences in serum PGⅠ, PGⅡlevels and PGR between Hp positive and Hp negative subjects in gastric cancer group, gastric ulcer group, atrophic gastritis group, superficial gastritis group and healthy control group (P＞0.05). Conclusion In the screening of gastric cancer and precancerous lesions, the detection of Hp antibody and PG has positive clinical diagnostic value and is worthy of promotion.
2020 Vol. 27 (25): 187-189转193 [Abstract] ( 33 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
190 Correlation analysis of sex hormone, blood lipid and body mass index with anti-mullerian hormone abnormality in patients with polycystic ovarian syndrome
WANG Jing
Objective To investigate the correlation of sex hormone, blood lipid and body mass index (BMI) with antimullerian hormone (AMH) abnormality in patients with polycystic ovarian syndrome (PCOS). Methods A total of 50 patients with PCOS who admitted to the hospital from January 2018 to December 2019 as the research objects were included in observation group, and 50 healthy controls during the same period in our hospital were included in control group. The AMH, sex hormones (luteinizing hormone [LH], follicle stimulating hormone [FSH], prolactin [PRL], estradiol [E2], testosterone [TESTO], progesterone [PROG]), blood lipid (total cholesterol [CHOL], triglyceride [TG]) contents and BMI of all PCOS patients and healthy controls were measured in serum samples from both groups, and the correlation of sex hormone, blood lipid, BMI and AMH in PCOS patients were analyzed. Results The BMI, LH, E2, TESTO,CHOL, TG and AMH in observation group were higher than those in control group, and the PRL, FSH, PROG in observation group were lower than those in control group, and the differences were statistically significant (P＜0.05). Pearson analysis showed that the levels of BMI, LH, E2, TESTO, CHOL and TG in PCOS patients were positively correlated with AMH (r＞0, P＜0.05). The PRL, FSH and PROG were negatively correlated with AMH (r＜0, P＜0.05). Conclusion The serum AMH has certain correlation with sex hormone (LH, FSH, PRL, E2, TESTO, PROG), blood lipid (CHOL, TG) and BMI in patients with PCOS. Therefore, early screening, treatment and prevention for PCOS patients have certain clinical significance.
2020 Vol. 27 (25): 190-193 [Abstract] ( 26 ) HTML (34 KB)  PDF  (0 KB)  ( 13 )
194 Application of joint management mode of narcotics by pharmacists and nurses in the operating room based on fault tree analysis
YE Mei-feng; HE Liu-jun; CHEN guang; HUANG Wei-xiang
Objective To explore the application of joint management mode of narcotics by pharmacists and nurses in the operating room based on the fault tree analysis. Methods Through the field investigation to understood the management mode of narcotics in the operating room, the existing problems in the management of narcotics in the operating room were analyzed by using the fault tree analysis, and a new mode of narcotics management by pharmacists and nurses in the operating room was proposed according to the risks and the problems. In our hospital, nurse management model of narcotic drugs from July 2017 to June 2018 was selected as the old model, the combined narcotics management in the operating room from July 2018 to June 2019 was selected as a new model, the occurrence times of expired,deteriorated, charging errors, prescription registration errors and empty ampoule losses found in the quality control inspection of narcotics in the operating room were statisticed and compared. Results During the new mode, the operating room charges errors, prescription registration and writing errors, and empty ampoules were less than the old model, and the differences were statistically significant (P＜0.05). Conclusion The joint management mode of narcotics by pharmacists and nurses can strengthen the supervision of narcotics in the operating rooms, standardize the use of narcotics,and improve the quality of narcotics management.
2020 Vol. 27 (25): 194-197 [Abstract] ( 28 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
198 Retrospective Analysis of Disease Distribution and Multiple Drug Use Related Factors in Elderly Outpatients of Primary Hospitals
LIANG Wei-liang ;TAN Jie-ying ;SONG Zhao-di ;PAN Chun-lin
Objective To explore the correlation between disease distribution of elderly patients and the influencing factors of multiple drug use. Methods Based on the hospital information system, extracted and analysised the prescription information (including patient gender, age, outpatient/inpatient number), clinical diagnosis, type and quantity of treatment drugs and payment methods and payment method of our hospital from June to December 2019. Results Among the 31 488 outpatients, 7886 cases (25.04%) were multiple drug uses. The top 5 frequencies of suffering diseases were followed by 13 139 (31.51%) of hypertension, 4678 (11.22%) of diabetes, 2451 (5.88%) of upper respiratory tract infection, 2403 (5.76%) of coronary heart disease and 1439 (3.45%) of cerebrovascular disease. Diseases in the multidrug patients were mainly concentrated in 751 cases of hypertension (2.39%), 858 cases of upper respiratory tract infection (2.72%), 286 cases of coronary heart disease (0.91%), 1119 cases of hypertension+diabetes (3.55%), 843 cases of hypertension + coronary heart disease (2.68%), 283 cases of hypertension+cerebrovascular disease (0.9%). Multivariate Logistic regression analysis showsed: employee specific disease (OR=1.113, 95%CI=1.039-1.193, P=0.00), age 70-＜80 years (OR=1.196, 95%CI=1.126-1.270, P=0.00), age ≥80 years old (OR=1.440, 95%CI=1.339-1.549, P=0.00) and suffering from two and more diseases (OR=3.836, 95%CI=3.635-4.048, P=0.00) were independent risk factors for multiple drugs. Conclusion There is a phenomenon of multiple drug use in elderly outpatients. We should make individualized treatment plan based on the characteristics of elderly patients, simplify the prescription drug treatment, and provide scientific and reasonable pharmaceutical services.
2020 Vol. 27 (25): 198-201 [Abstract] ( 25 ) HTML (36 KB)  PDF  (0 KB)  ( 11 )
202 Application of the knowledge, attitude/belief, practice model in the management of chronic diseases in patients with rheumatoid arthritis
CHEN Min; LYU Xiao-yan ;FANG Qun
Objective To explore the application of the knowledge, attitude/belief, practice (KAP) model in the management of chronic diseases in patients with rheumatoid arthritis. Methods A total of Sixty-two patients with rheumatoid arthritis admitted to our hospital from January to March 2019 were selected as the research subjects. They were divided into control group (n=31) and observation group (n=31) according to random number table method. In the control group, chronic rheumatic disease management model was used, and in the observation group, chronic rheumatic disease management model+KAP model were used. The disease knowledge awareness, attitude level, disease management behavior level and nursing total satisfaction of the two groups were compared. Results After intervention, the disease knowledge awareness, positive attitude, and disease management behavior scores in the rheumatoid arthritis patients after intervention through KAP questionnaire in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). In the observation group, the nursing total satisfaction was higher than that of the control group, with statistical difference (P＜0.05). Conclusion The KAP model can effectively improve the awareness of disease knowledge, positive attitude, disease management behavior level and nursing satisfaction of patients with rheumatoid arthritis, and the clinical application effect is good.
2020 Vol. 27 (25): 202-204转208 [Abstract] ( 22 ) HTML (32 KB)  PDF  (0 KB)  ( 14 )
205 Influence of individualized nursing intervention on negative emotion and behavior of patients with mental retardation and behavior disorder
WU Li-hua ;ZHANG Xing-lian; ZENG Hai-yan
Objective To explore the influence of individualized nursing intervention on negative emotion and behavior of patients with mental retardation and behavior disorder. Methods From September 2018 to August 2019, 44 patients with mental retardation and behavior disorder who were diagnosed and treated in the Third People′s Hospital of Foshan City in Guangdong Province were selected, and they were divided into the control group and the observation group according to the random number table method, 22 cases in each group. The control group was given routine nursing, and the observation group was given individualized nursing intervention on this basis. The scores of self rating anxiety scale(SAS), self rating depression scale (SDS) and social function defect screening scale (SDSS) were observed and compared between the two groups. Results Before intervention, the scores of SAS, SDS and SDSS in the observation group were(57.66±6.82)，(56.25±7.15), (15.89±2.14) points respectively, and those in the control group were (57.23±7.04), (56.64±7.22), (16.02±2.05) points respectively, without significant difference between the two groups (P＞0.05). After intervention, the SAS, SDS and SDSS scores of the observation group were (38.48±5.29), (37.36±6.12) and (7.54±2.31) points,which were lower than those of the control group ([43.26±5.06], [41.28±6.45]and [12.16±2.35]points), the differences were statistically significant (P＜0.05). The scores of SAS, SDS and SDSS in the observation group after intervention were lower than those before intervention, the differences were statistically significant (P＜0.05). The compliance rate of the observation group was 100.00%, which was higher than that of control group (68.18%), the difference was statistically significant (P＜0.01). Conclusion For patients with mental retardation combined with behavioral disorders, personalized nursing intervention can effectively improve the negative emotions of patients, control their negative behavior,improve nursing dependence, and provide new clinical diagnosis, treatment and nursing methods for such patients.
2020 Vol. 27 (25): 205-208 [Abstract] ( 26 ) HTML (35 KB)  PDF  (0 KB)  ( 12 )
209 Application effect of hook-type electrocardiogram cart in the management of chest pain time
WANG Su-xian
Objective To investigate the application effect of hook-type electrocardiogram cart in the management of chest pain time. Methods The clinical data of 120 patients with chest pain who were admitted to our hospital from June to December 2019 were retrospectively analyzed. All patients were divided into two groups according to different types of electrocardiogram cart, control group (n=60, ordinary electrocardiogram cart during emergency nursing) and observation group (n=60, hook-type electrocardiogram cart during emergency nursing). The emergency time after admission, the incidence of major adverse cardiovascular events during hospitalization and satisfaction of family members were compared between two groups. Results The first electrocardiogram time, analysis time of chest pain causes, start time of emergency and hospital stays in observation group were shorter than those in control group, and the differences were statistically significant (t=32.233, 10.068, 7.770, 12.110, P=0.000). The total incidence of major adverse cardiovascular events during hospitalization in observation group was lower than that in control group, and the difference was statistically significant (χ2=4.227, P=0.040). The total satisfaction of family members in observation group was higher than that in control group, and the difference was statistically significant (χ2=6.171, P=0.013). Conclusion Hook-type electrocardiogram cart for patients with chest pain can shorten the first electrocardiogram time after admission, analysis time of chest pain causes, start time of emergency and hospital stays, timely provide diagnosis and treatment for the patients, reduce prognostic risks, and improve satisfaction of family members, which is worthy of clinical promotion and application.
2020 Vol. 27 (25): 209-211 [Abstract] ( 23 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
212 Application of pain nursing combined with palliative care in the nursing of patients with advanced gastric cancer
ZHONG Qing ;ZHONG Xiao-juan; LIU Zhi-fang
Objective To explore the application of pain nursing combined with palliative care in the nursing of patients with advanced gastric cancer. Methods A total of 80 patients with advanced gastric cancer treated in our hospital from January 2017 to January 2018 were selected and divided into control group (n=40) and experimental group (n=40)according to random number table method. The experimental group was treated with pain nursing and palliative care,and the effects were compared. Results The total satisfaction of the experimental group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The scores of self-rating anxiety scale (SAS) and self rating depression scale (SDS) in the experimental group were lower than those in the control group, while the scores of quality of life scale in patients with gastric cancer were higher than those in the control group, the differences were statistically significant (P＜0.05). The cognitive score of gastric cancer knowledge in the experimental group was higher than that in the control group, the time of pain relief and the time of using analgesics in the experimental group were shorter than those in the control group, and the survival time in the experimental group was longer than that in the control group, the differences were statistically significant (P＜0.05). The total incidence of nurse-patient disputes in the experimental group was lower than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Pain nursing combined with palliative care can achieve better results in patients with advanced gastric cancer.
2020 Vol. 27 (25): 212-214 [Abstract] ( 28 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
215 Application value of path comprehensive nursing in tibial fracture
ZHANG Wei;ZENG Hui-hua; DENG Shu-lin;HU Chao-hua
Objective To explore the role of pathway comprehensive nursing in tibial fracture. Methods A total of 60 patients with tibial fracture admitted to the Third Affiliated Hospital of Gannan Medical University, Ruijin Hospital of Traditional Chinese Medicine and Ruijin People′s Hospital from January 2019 to January 2020 were selected for study.According to the order of admission, the patients were divided into control groups and observation group, 30 cases in each group. The control group was given routine nursing and the observation group was given comprehensive nursing.The scores of Zung self rating anxiety scale (SAS) and Zung self rating depression scale (SDS) before and after nursing were compared between the two groups, as well as the incidence of complications and satisfaction. Results There was no significant difference in psychological state between the two groups before nursing (P＞0.05). The psychological state score of the observation group after nursing was lower than that of the control group (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group, and the total satisfaction was higher than that in the control group, with statistical differences (P＜0.05). Conclusion The comprehensive nursing of tibial fracture patients can alleviate the negative emotions, prevent the complications, promote the patients′ satisfaction, it has the value of popularization and application.
2020 Vol. 27 (25): 215-217 [Abstract] ( 20 ) HTML (34 KB)  PDF  (0 KB)  ( 10 )
218 Analysis of first aid measures and nursing measures for patients with cerebrovascular accident to open green channel
LIAO Ling; HUANG Xiao-yu
Objective To explore the effect of emergency green channel in patients with cerebrovascular accident(CVA) and related nursing strategies. Methods From October 2017 to October 2018, 53 patients with CVA admitted to our hospital during the routine emergency procedures were selected as the control group; from November 2018 to November 2019, 53 patients with CVA admitted to our hospital during the green channel of emergency care were selected as the observation group. The response time, treatment effect and nursing satisfaction of the two groups were compared. Results The time of emergency department was (25.37±6.82) min, emergency department rescue was (22.41±5.87) min and treatment time was (52.36±9.87) min in the observation group, were shorter than those in the control group of (32.14±6.84), (26.57±5.98), (65.37±10.54) min, with statistical differences (P＜0.05). The cure rate of the observation group was 69.81%, which was higher than that of control group (35.85%). The total incidence of sequelae of the disease was 28.30%, lower than 49.06% of the control group, the difference was statistically significant (P＜0.05).The total satisfaction rate of the observation group was 96.23%, which was higher than that of the control group(79.25%), the difference was statistically significant (P＜0.05). Conclusion Emergency green channel can effectively shorten the treatment time of CVA patients, and take active nursing measures can improve the success rate of treatment and nursing satisfaction, reduce the incidence of sequelae.
2020 Vol. 27 (25): 218-220 [Abstract] ( 24 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
221 Application effect of comprehensive nursing intervention in the patients with posterior circulation ischemic vertigo
GUO Fen ;SU Xiao-yu

Objective To explore the application effect of comprehensive nursing intervention in the patients with posterior circulation ischemic vertigo. Methods A total of 68 patients with posterior circulation ischemic vertigo who were treated in our hospital from March 2017 to March 2019 were selected and divided into two groups according to the random number table method, 34 cases in each group. The control group was given routine care, and the observation group was given comprehensive nursing intervention. The vertigo degree, Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD) and self-care ability for daily living (Barthel) scores before intervention and 7 d after intervention were compared between the two groups. Results There was no statistically significant difference in vertigo degree, HAMA, HAMD and Barthel scores before intervention between the two groups (P＞0.05); the effect of improving the vertigo after intervention in the observation group was better than that in the control group, and the difference was statistically significant (P＜0.05); the HAMA and HAMD scores in the observation group after intervention were lower than those in the control group, and the differences were statistically significant (P＜0.05); the Barthel score in the observation group after intervention was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Comprehensive nursing intervention can reduce the vertigo degree in the patients with posterior circulation ischemic vertigo, effectively relieve negative emotions such as anxiety and depression, and help to improve patients′ self-care ability for daily living. It is therefore worthy of promotion and application.
2020 Vol. 27 (25): 221-224 [Abstract] ( 24 ) HTML (35 KB)  PDF  (0 KB)  ( 11 )
225 Application of nursing model based on psychological and social factors in patients with duodenal ulcer
CHEN Xiao-piao; LIAO Qiu-hong; RAO Lu
Objective To explore the application of nursing model based on psychological and social factors in patients with duodenal ulcer. Methods A total of 80 patients with duodenal ulcer admitted to our hospital from March 2018 to June 2019 were selected as the study objects, the patients were divided into the observation group and the control group according to the random number table method, 40 cases in each group. The patients in the control group were given routine nursing, while the observation group was given psychological social factors based nursing mode on the basis of the control group. Anxiety symptom score and quality of life score before and after nursing, the degree of total nursing satisfaction were compared between the two groups. Results The scores of anxiety symptoms in the two groups after nursing were lower than those before nursing, the quality of life scores of the two groups after nursing were higher than those before nursing, the differences were statistically significant (P＜0.05). The score of anxiety symptoms in the observation group after nursing was lower than that in the control group, the quality of life score of the observation group after nursing was higher than that in the control group, the differences were statistically significant (P＜0.05). The total satisfaction degree of the patients in the observation group (97.50%) was higher than 77.50% in the control group,the difference was statistically significant (P＜0.05). Conclusion The application effect of the nursing mode based on psychological and social factors in patients with duodenal ulcer is significant, which can reduce the anxiety symptoms of patients, improve the quality of life of patients and the satisfaction of nursing, it is worthy of clinical application.
2020 Vol. 27 (25): 225-227 [Abstract] ( 27 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
228 Application effect of comprehensive nursing intervention in oral treatment of diabetic patients with chronic periodontitis
WANG Yuan ;ZHENG Chun-mei; GUO Xiao-yan
Objective To explore the application effect of comprehensive nursing intervention in oral treatment of diabetic patients with chronic periodontitis. Methods A total of 100 patients with diabetes with chronic periodontitis treated in our hospital from May 2018 to May 2019 were selected as the subjects of the study, and divided into the control group (n=50) and study group (n=50) by the random drawing method. The control group adopts routine nursing, and the study group adopts comprehensive nursing intervention measures. The dental plaque index, bleeding index and psychological status score of the two groups before and after nursing were compared, the clinical nursing compliance of the two groups was compared, and the clinical nursing satisfaction of the two groups was compared. Results There was no significant difference in dental plaque index between the two groups (P＞0.05); the dental plaque index of the two groups after nursing was lower than that before nursing, the dental plaque index of the study group was lower than that of the control group after nursing, the differences were statistically significant (P＜0.05). There was no significant difference in bleeding index between the two groups before nursing (P＞0.05); the bleeding index of two groups after nursing was lower than that before nursing, the bleeding index of the study group after nursing was lower than that of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) between the two groups before nursing (P＞0.05);the SAS and SDS scores of the two groups after nursing were lower than those before nursing, the SAS and SDS scores of the study group after nursing were lower than those of the control group, the differences were statistically significant(P＜0.05). The clinical nursing total compliance rate after nursing in the study group was higher than that of the control group, the clinical nursing total satisfaction of the patients in the study group after nursing was higher than that in the control group, the differences were statistically significant (P＜0.05). Conclusion It is effective to carry out comprehensive nursing intervention in the oral treatment of patients with diabetes and chronic periodontitis.
2020 Vol. 27 (25): 228-230转234 [Abstract] ( 24 ) HTML (36 KB)  PDF  (0 KB)  ( 19 )
231 Application effect of integrated traditional Chinese and Western medicine nursing in patients with esophageal cancer
HUANG Hong-lian
Objective To explore the application effect of integrated traditional Chinese and Western me dicine nursing in patients with esophageal cancer. Methods Fifty-six patients with esophageal cancer admitted to our hospital from January to December 2018 were selected and divided into two groups according to random number table method, 28 cases in each group. The control group was given routine nursing, and the study group was given integrated traditional Chinese and Western medicine nursing. Both groups were intervened for 3 months. The scores of self-rating anxiety scale (SAS), self-rating depression scale（SDS）, Pittsburgh sleep quality index scale (PSQI) and supplementary pattern table of esophageal cancer (QLQ-OES18) were compared between the two groups. Results There were no significant differences in SAS, SDS scores, PSQI and QLQ-OES18 scores between the two groups before intervention (P＞0.05);SAS, SDS scores, PSQI and QLQ-OES18 scores after intervention in the two groups were lower than those before intervention, with statistical differences; SAS, SDS, PSQI and QLQ-OES18 scores after intervention in the study group were lower than those of the control group, with statistical differences (P＜0.05). Conclusion Nursing with integrated traditional Chinese and Western medicine for patients with esophageal cancer can effectively improve their mental state,sleep quality and quality of life.
2020 Vol. 27 (25): 231-234 [Abstract] ( 30 ) HTML (36 KB)  PDF  (0 KB)  ( 13 )
235 Application of clinical nursing pathway combined with rapid rehabilitation concept in perioperative period of rectal cancer patients
WANG Xue
Objective To explore the effect of clinical nursing pathway combined with the concept of rapid rehabilitation in the perioperative period of patients with rectal cancer. Methods A total of 116 patients with rectal cancer treated in our hospital from September 2017 to December 2018 were selected as the research objects and analyzed retrospectively. They were divided into control group (n=58) and study group (n=58). The control group adopts the routine nursing model, the study group adopts the clinical nursing pathway combined with the rapid recovery concept intervention, the postoperative recovery indicators and the incidence of complications between the two groups of patients were compared. Results The total incidence of complications in the study group (5.17%) was lower than that in the control group (18.97%), and the difference was statistically significant (P＜0.05); gastrointestinal function recovery time, hospital stay time, and out-of-bed activity in the study group were shorter than those of the control group, and the hospitalization cost was less than that of the control group, the differences were statistically significant (P＜0.05). Conclusion The clinical nursing pathway combined with the concept of rapid rehabilitation has outstanding effect in the perioperative period of patients with rectal cancer. It can recover the gastrointestinal function of patients as soon as possible, get out of bed early, recover and discharge from hospital with less complications. It is suggested to make the first choice of nursing plan for patients with rectal cancer in the perioperative period.
2020 Vol. 27 (25): 235-237 [Abstract] ( 25 ) HTML (30 KB)  PDF  (0 KB)  ( 16 )
238 Application of perioperative accurate nursing intervention in patients with colon cancer
CHENG Yuan
Objective To explore the application of accurate perioperative nursing intervention in patients with colon cancer. Methods From January 2018 to July 2019, 96 colon cancer patients in our hospital were selected as the research objects. According to the envelope method, they were divided into the control group (n=48) and the observation group (n=48). The control group adopted the routine perioperative nursing method, and the observation group adopted the accurate nursing intervention method for the perioperative period of colon cancer, the quality of life, psychological state and total incidence of postoperative complications of the two groups were compared. Results After nursing, the scores of appetite, mental state, sleep quality, life ability, self cognition, social support and other quality of life indexes in the observation group were higher than those in the control group, with statistical significances (P＜0.05); the scores of anxiety and depression in the observation group were lower than those in the control group, with statistical significances (P＜0.05); the total incidence of complications in the observation group was lower than that in the control group,with poor results one week after operation, the difference was statistically significant (P＜0.05). Conclusion Accurate nursing intervention in the perioperative period of colon cancer patients can effectively improve their quality of life, improve their psychological state and reduce the incidence of postoperative complications.
2020 Vol. 27 (25): 238-240转243 [Abstract] ( 25 ) HTML (33 KB)  PDF  (0 KB)  ( 11 )
241 Application effect of targeted nursing intervention in elderly patients with deep vein thrombosis after laparoscopic cholecystectomy
GUO Yu-mei
Objective To explore the application effect of targeted nursing intervention in elderly patients with lower extremity deep vein thrombosis (DVT) after laparoscopic cholecystectomy (LC). Methods From October 2018 to April 2019, 100 elderly patients with DVT after LC were selected and divided into control group and observation group according to the time of admission, 50 cases in each group. The control group received routine nursing and the observation group received targeted nursing intervention. The coagulation index, complication rate and nursing satisfaction of the two groups were compared. Results The fibrinogen (FIB) and D-dimers (D-D) levels of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that of the control group, the nursing total satisfaction of patients in the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05).Conclusion The targeted nursing intervention for the elderly patients with DVT after LC can effectively improve the coagulation function, reduce the risk of complications, and improve the nursing satisfaction, which is worth clinical promoting.
2020 Vol. 27 (25): 241-243 [Abstract] ( 26 ) HTML (30 KB)  PDF  (0 KB)  ( 10 )
244 Application of perioperative psychological nursing in patients with anal fistula
JIAO Yan
Objective To explore the application of perioperative psychological nursing in patients with anal fistula.Methods Altogether 80 patients with anal fistula who received surgical treatment in our hospital from July 2018 to July 2019 were selected and divided into control group (n=40) and study group (n=40) according to odd even grouping mode.The control group was given perioperative routine nursing intervention, while the study group was given perioperative psychological nursing on the basis of the control group. The improvement of anxiety, depression and other negative emotions, quality of life and nursing satisfaction were compared between the two groups before and after nursing. Results The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) of the two groups after nursing were lower than those before nursing, with statistical differences (P＜0.05); and the scores of SAS and SDS of the study group after nursing were lower than those of the control group, with statistical differences (P＜0.05). The quality of life scores of the two groups after nursing were higher than those before nursing, and the quality of life scores of the study group after nursing were higher than those of control group, with statistical differences (P＜0.05) . The nursing total satisfaction degree of the study group was higher than that of the control group, with statistical difference (P＜0.05).Conclusion Application of perioperative psychological nursing intervention in patients with anal fistula is helpful to alleviate the negative emotions such as anxiety and depression，and improve the patients′ quality of life significantly. At the same time, it can also build a harmonious relationship between nurses and patients and reduce the occurrence of disputes between nurses and patients, which has a positive significance in clinical promotion.
2020 Vol. 27 (25): 244-246 [Abstract] ( 23 ) HTML (30 KB)  PDF  (0 KB)  ( 11 )
247 Application of evidence-based nursing intervention in laparoscopic cholecystolithiasis
ZHENG Wei
Objective To explore the effect of evidence-based nursing intervention in laparoscopic surgery for patients with gallstone. Methods A total of 70 patients with gallstones who underwent laparoscopic surgery in our hospital from February 2018 to February 2019 were selected as the research subjects. They were divided into the control group (n=35) and the observation group (n=35) according to the random number table method. The control group received traditional nursing care. On the basis of this, the observation group implemented evidence-based nursing interventions, the pain of the two groups before the intervention and on the 2 day after the operation, the quality of life of the two groups at 4 weeks and 6 months after operation were compared. Results There was no significant difference between the two groups in the score of visual analog pain perception before intervention (P＞0.05). On the second day after surgery, the pain scores of the two groups were lower than those before the intervention, and the observation group was lower than the control group, with statistical differences (P＜0.05). The scores of physical pain, physical function, mental health and vitality in the observation group were higher than those in the control group at 4 weeks and 6 months after operation，the differences were statistically significant (P＜0.05). Conclusion For patients with gallbladder stones undergoing surgical treatment, evidence-based nursing intervention can reduce their postoperative pain, improve quality of life, and have marked clinical application value.
2020 Vol. 27 (25): 247-249 [Abstract] ( 28 ) HTML (30 KB)  PDF  (0 KB)  ( 11 )
250 Application value of cognitive behavior nursing in patients undergoing glaucoma surgery
WANG Xiao-xia
Objective A total of To analyze the application value of cognitive behavior nursing in patients with glaucoma surgery. Methods A total of 78 cases of glaucoma surgery patients admitted to our hospital from January 2018 to May 2019 were selected as the research objects. They were divided into control group (n=39) and observation group (n=39) according to random single and even number method. The control group received routine nursing, the observation group was given cognitive nursing. The intervention effect of two different nursing methods were compared. Results The scores of health knowledge, self-care responsibility, self-care skills and self-care effect in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the scores of psychological status between the two groups before nursing (P＞0.05). The scores of anxiety and depression in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The total effective rate of the observation group was 97.44% (38/39)higher than that of the control group,79.49%(31/39),the difference was statistically significant (P＜0.05). Conclusion Cognitive behavioral intervention for glaucoma surgery patients can not only effectively improve the knowledge of patients, but also improve the treatment effect of patients, which has clinical application value.
2020 Vol. 27 (25): 250-252 [Abstract] ( 27 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
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