戈舍瑞林联合腹腔镜术对子宫内膜异位症患者性激素及血管相关指标水平的影响

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (34 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the effect of Goserelin combined with laparoscopic surgery on the levels of sex hormones and vascular-related indices in the patients with endometriosis (EMT). Methods A total of 92 patients with EMT who were treated in our hospital from November 2016 to October 2018 were selected and divided into two groups according to the random number table method, with 46 patients in each group. The control group was given laparoscopic surgery, and the observation group was given Goserelin combined with laparoscopic surgery. The sex hormones (follicle stimulating hormone [FSH], estradiol [E2], luteinizing hormone [LH]), vascular-related indices (angiogenin-2 [Ang-2],vascular growth factor [VEGF]), adverse reactions and recurrence rate were compared between the two groups. Results The differences of the levels of FSH, E2, LH, Ang-2 and VEGF in the two groups before treatment were not statistically significant (P＞0.05); after treatment, FSH ([3.88±0.97]mmol/L), E2 ([12.45±4.18]mmol/L), LH ([0.58±0.22]mmol/L),Ang-2 ([2.14±0.85]mg/L) and VEGF ([1.12±0.41]mg/L) in the observation group were respectively lower than those in the control group ([4.90±1.15]mmol/L, [23.14±6.79]mmol/L, [1.48±0.54]mmol/L, [3.21±1.10]mg/L, [1.81±0.65]mg/L),and the differences were statistically significant (P＜0.05); the recurrence rate in the observation group was 4.35%, lower than 19.57% in the control group, and the difference was statistically significant (P＜0.05); the difference in the total incidence rate of adverse reactions between the two groups was not statistically significant (P ＞0.05). Conclusion Goserelin combined with laparoscopic surgery in the treatment of EMT can reduce the recurrence rate, improve patients' sex hormone levels and vascular-related indices,and have fewer adverse reactions.

Key words： Endometriosis Goserelin Laparoscopic surgery Sex hormones Vascular-related indices

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	JIA Rui-juan
	SHUAI Jian-gang
	DONG Ju-lang

Cite this article:

JIA Rui-juan,SHUAI Jian-gang,DONG Ju-lang. Effect of Goserelin combined with laparoscopic surgery on the levels of sex hormones and vascular -related indices in the patients with endometriosis[J]. 中国当代医药, 2020, 27(25): 115-117.

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I25/115

[1]	韩肖彤，郭红燕，孔东丽，等.子宫内膜异位症诊断延迟的原因及影响因素探讨[J].中华妇产科杂志，2018，53（2）：92-98.
[2]	朱丽波，丁少杰，竺天虹，等.子宫内膜异位症患者异位内膜和在位内膜组织中P2X3 的表达及其意义[J].中华妇产科杂志，2017，52（4）：264-267.
[3]	钱睿亚，卢丹，盛洁，等.腹腔镜手术治疗子宫内膜异位症合并不孕患者术后后续治疗的方法探讨[J].北京医学，2017，39（6）：603-606.
[4]	张小莎，张伟.活血化瘀中药联合腹腔镜手术对子宫内膜异位症不孕患者MCP-1、RANTES、氧化应激及性激素水平的影响[J].海南医学院学报，2017，23（21）：2956-2959.
[5]	张亚娜，管付娟，李强.妇科千金胶囊联合戈舍瑞林治疗子宫内膜异位症的临床研究[J].现代药物与临床，2019，34（4）：1095-1099.
[6]	武明娟，陈燕荣，车海沙，等.腹腔镜联合GnRHa 对不同程度子宫内膜异位症性不孕患者妊娠率的影响[J].贵州医药，2019，43（5）：735-737.
[7]	俞菊红.子宫内膜异位症患者盆腔痛与子宫内膜氧化应激、血流动力学指标的关系[J].浙江医学，2018，40（12）：1328-1330，1337.
[8]	高剑华，陈玉蓉，崔静，等.腹腔镜手术联合米非司酮治疗子宫内膜异位症效果观察[J].山东医药，2017，57（10）：72-74.
[9]	焦海宁，朱岚，吴步初，等.子宫内膜异位症患者腹腔镜术后生殖预后的影响因素分析[J].中国医师杂志，2018，20（12）：1807-1809，1813.
[10]	桂华，曹珊珊，赵巧云，等.克龄蒙联合戈舍瑞林对子宫内膜异位症患者腹腔镜术后血清激素水平的影响[J].中国临床药理学与治疗学，2018，23（5）：557-560.
[11]	陈秀，高丽丽.子宫内膜异位症保守手术术后联合应用戈舍瑞林的辅助性治疗作用[J].山西医药杂志，2018，47（5）：552-554.
[12]	魏顺英，王烈宏，祁青玲，等.子宫内膜异位症患者血清与腹腔液中CRP、IL-8、VEGF 的表达及临床意义[J].中国医药导报，2019，16（12）：89-92，104.
[13]	陈志华，李爱军，白晶，等.子宫内膜异位症患者血清VEGF、HE4 及MMP-9 的表达及意义[J].中国实验诊断学，2018，22（11）：1946-1948.
[14]	陈灵灵，欧阳娟.醋酸戈舍瑞林缓释植入剂联合腹腔镜手术治疗子宫内膜异位症合并不育症的疗效观察[J].中国医院用药评价与分析，2018，18（1）：62-63，65.
[15]	杨晓琼，杜小琴.腹腔镜手术联合戈舍瑞林治疗子宫内膜异位症合并不孕症的疗效及对血清MMP-9、TIMP-1水平的影响[J].中国妇幼保健，2017，32（18）：4486-4489.