Objective To explore the application effect of comprehensive nursing intervention in the patients with posterior circulation ischemic vertigo. Methods A total of 68 patients with posterior circulation ischemic vertigo who were treated in our hospital from March 2017 to March 2019 were selected and divided into two groups according to the random number table method, 34 cases in each group. The control group was given routine care, and the observation group was given comprehensive nursing intervention. The vertigo degree, Hamilton anxiety scale (HAMA), Hamilton depression scale (HAMD) and self-care ability for daily living (Barthel) scores before intervention and 7 d after intervention were compared between the two groups. Results There was no statistically significant difference in vertigo degree, HAMA, HAMD and Barthel scores before intervention between the two groups (P＞0.05); the effect of improving the vertigo after intervention in the observation group was better than that in the control group, and the difference was statistically significant (P＜0.05); the HAMA and HAMD scores in the observation group after intervention were lower than those in the control group, and the differences were statistically significant (P＜0.05); the Barthel score in the observation group after intervention was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Comprehensive nursing intervention can reduce the vertigo degree in the patients with posterior circulation ischemic vertigo, effectively relieve negative emotions such as anxiety and depression, and help to improve patients′ self-care ability for daily living. It is therefore worthy of promotion and application.