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| Application effect of Terbutaline combined with Azithromycin sequential therapy in children with pneumonia |
| DING Yuan-yuan |
| Department of Pediatrics, He Xian Memorial Hospital, Panyu District, Guangdong Province, Guangzhou 510000, China |
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Abstract Objective To investigate the effect of Terbutaline combined with Azithromycin sequential therapy in children with pneumonia. Methods A total of 86 children with pneumonia admitted to our hospital from January 2017 to January 2019 were selected as the subjects, and they were divided into observation group and control group, with 43 cases in each group by random number table method. The control group was treated with routine medicine and Azithromycin, and the observation group was treated with Terbutaline on the basis of the control group. The changes of airway inflammatory factors (hypersensitive-C-reactive protein [hs-CRP], tumor necrosis factor-α [TNF-α]), pulmonary function [forced expiratory volume in the first second (FEV1), forced vital capacity (FVC)]were compared between the two groups before treatment and 14 days after treatment; the time of symptom disappearance (antipyretic time, antitussive time) and hospitalization time were compared between the two groups; the adverse reactions were compared between the two groups. Results Before treatment, there were no significant differences in TNF-α and hs-CRP between the two groups (P＞0.05); after 14 days of treatment, the hs-CRP and TNF-α of children of the two groups were lower than those before treatment, and the TNF-α and hs-CRP levels of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). Before treatment, there were no significant differences in FEV1 and FVC levels between the two groups (P＞0.05); after 14 days of treatment, the FEV1 and FVC levels of the two groups of children were higher than those before treatment, and the FEV1 and FVC levels of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). The time of antipyretic, antitussive and hospitalization in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05);there was no significant difference in total adverse reactions between the two groups (P＞0.05). Conclusion Terbutaline-assisted Azithromycin sequential therapy of pediatric pneumonia can effectively reduce the level of airway inflammatory factors in children, improve the lung function of the patients, accelerate the resolution of symptoms, reduce the length of hospitalization in children, and has good safety.
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