噻托溴铵吸入联合糖皮质激素治疗慢性阻塞性肺气肿的临床效果

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Abstract Objective To explore the clinical effect of Tiotropium Bromide Inhalation combined with Glucocorticoid in the treatment of chronic obstructive pulmonary emphysema. Methods According to the order of visits, 94 patients with chronic obstructive pulmonary emphysema admitted to our hospital from October 2017 to August 2019 were randomly divided into observation group and control group, 47 cases in each group. The observation group were treated with Tiotropium Bromide Inhalation combined with Glucocorticoid, and the control group were treated with Tiotropium Bromide Inhalation only. The total effective rate of drug treatment, the improvement of pulmonary function indicators before and after treatment, blood gas indicators, 6-minute walking distance (6MWD) and the total incidence of drug adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 93.62%, which was higher than that in the control group of 76.60%, the difference was statistically significant (P＜0.05). After treatment, the levels of forced vital capacity (FVC), forced expiraton volumone second (FEV1),FEV1/FVC and maximum ventilation (MVV) of patients of the two groups were higher than those of the group before treatment, the differences were statistically significant (P＜0.05); the FVC, FEV1, FEV1/FVC and MVV levels of the observation group after treatment were higher than those of the control group, and the differences were statistically significant (P＜0.05). The partial pressure of blood oxygen (PaO2) of the observation group was higher than that of the control group, the partial pressure of blood carbon dioxide (PaCO2) was lower than that of the control group, and the 6MWD was longer than that of the control group, the differences were statistically significant (P＜0.05). The total incidence of drug adverse reactions in the observation group was 8.51%, which was lower than that in the control group of 23.40%, the difference was statistically significant (P＜0.05). Conclusion Tiotropium Bromide Inhalation combined with Glucocorticoid in the treatment of chronic obstructive pulmonary emphysema can improve the clinical treatment efficiency of patients, improve the pulmonary function and blood gas indicators of patients, improve the exercise tolerance of patients,and reduce the incidence of drug adverse reactions.

Key words： Tiotropium Bromide Inhalation Glucocorticoids Chronic obstructive pulmonary emphysema Clinical application

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ZHAO Nan. Clinical effect of Tiotropium Bromide Inhalation combined with Glucocorticoid in the treatment of chronic obstructive pulmonary emphysema[J]. 中国当代医药, 2020, 27(25): 37-39转43.

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https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I25/37

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