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Quick Search     Adv Search 2016 Vol. 23, No. 15 Published: 2016-05-28   4 Identification of Saposhnikovia divaricata and its adulterants based on DNA barcode(ITS2) LIN Hao;QIAN Jie-ying;LI Si-lu;OU Hui-hong;XIA Hai-shan;LIU Yong Objective To identify Saposhnikovia divaricata and its adulterants by using ITS2 sequence analysis and to secure medication safety.Methods ITS2 sequences of Saposhnikovia divaricata and its adulterants were downloaded from GenBank，MEGA 6.06 software was used for sequence analysis to summarize GC content，variation sites，estimate intra-and inter-specific genetic distances，and built NJ trees.Moreover，the secondary structure of ITS2 was predicted by using the ITS2 database websites.Results ITS2 sequence analysis and genetic distances calculation showed significant difference in the samples.Further more，NJ tree and secondary structure results could distinctly differentiate quality product and adulterants.Conclusion ITS2 can effectively identify Saposhnikovia divaricata and its adulterants，as a result，it can be used for rapid identification of Chinese medicinal materials. 2016 Vol. 23 (15): 4-7 [Abstract] ( 130 ) HTML (44 KB)  PDF  (0 KB)  ( 27 ) 8 Development of kits of a single antibody sandwich ELISA for quantitative detection of human nerve growth factor XU Chun-E;WANG Wei;DING Rui;JI Hong;WU Xiao-hong;TIAN Guang Objective To prepare mouse monoclonal antibody against human nerve growth factor（hNGF）and develop an ELISA kits for quantitative detection of hNGF.Methods BALB/c mice were immunized with recombinant human nerve growth factor antigen and Freund′s complete adjuvant，the monoclonal antibody against hNGF was prepared by the technique of hybridoma，and then the ELISA detection kit for rapid detection of hNGF content was established.Results 1 hybridoma cell line secreting monoclonal antibodies against hNGF was obtained.1 ELISA kits for the detection of hNGF content was established.The recovery rate of the detection method was 85%-105%，the sensitivity was 0.63 ng/ml，the coefficient of variation was less than 10%，and the peculiarity was good.Conclusion A monoclonal antibody against hNGF is successfully prepared，a rapid and precise ELISA kit is established for detection of rhNGF content. 2016 Vol. 23 (15): 8-12 [Abstract] ( 152 ) HTML (58 KB)  PDF  (0 KB)  ( 28 ) 13 Research Progress of migraine resting state fMRI GONG Yuan-yuan;WANG Jun;PAN Hui-hui;ZHANG Hong;LIU Lei;SONG Lian-ying;ZHANG Li-ping;JIANG Gen-di Neuroimaging studies of migraine have led to the understanding of the pathogenesis of migraine from pure vascular hypothesis to the hypothesis of neural vessels to the current theory of central nervous system.Based on the advantages of single intervention program，less interference factors，easy to control and so on，the resting state fMRI technology has become a research central hot spot to explore the mechanism of migraine.In this paper，the research progress of migraine with different methods of resting state fMRI is summarized. 2016 Vol. 23 (15): 13-15转19 [Abstract] ( 133 ) HTML (43 KB)  PDF  (0 KB)  ( 9 ) 16 Safety study Progress of nucleoside（nucleotide）analogue in the treatment of chronic hePatitis B LIU Yan-qin;MA Ting;WANG Jian-mei;XIONG Hui2 As a kind of global disease，chronic hepatitis B is a serious threat to human health.Now，nucleoside（nucleotide）analogue（NA）is widely used in the treatment of chronic hepatitis B，and the reports of adverse reactions about these drugs at home and abroad gradually increases.During the long-term treatment of chronic hepatitis B，NA caused a variety of adverse reactions should fully understand，which not only includes some high incidence adverse reactions，some potential or rare adverse reactions should also be pay attention.For the safety evaluation of drugs not only can prevent the adverse reaction to make them maximizes the effectiveness，but also can enhance the patient′s compliance，enhance late effects，improve prognosis and enhance life quality.So it has very important clinical significance.This article refers to the relevant medical literature and makes summary about the adverse reactions for these drugs. 2016 Vol. 23 (15): 16-19 [Abstract] ( 140 ) HTML (46 KB)  PDF  (0 KB)  ( 31 ) 20 Analysis of related factors of tobacco dePendence of chronic obstructive Pulmonary disease Patients in Kunming area BI Hong;JIN Zhi-xian;LI Hang;DU Jun-yi;CHEN Min Objective To investigate the related factors of tobacco dependence of chronic obstructive pulmonary disease （COPD）patients in Kunming area.Methods A total of 300 patients with COPD were selected from 5 tertiary hospitals in Kunming area for investigation from August 2014 to February 2015.The related factors of tobacco dependence in COPD patients were analyzed by filling in and collecting self-designed questionnaire.Results Among 300 cases of patients，there were 294 cases of male and 6 cases of female，their tobacco dependence scores was（5.64±2.13）points.There were 202 cases of ex-smoker（67.3%）and 98 cases of smoker（32.7%）.Single factor analysis showed that the tobacco dependence scores had statistically significant differences in patients with different cultural degree，economic income，smoking index（P＜0.05）.Multiple regression analysis showed that，tobacco dependence score=1.152+1.43×smoking index.Conclusion Tobacco dependence of COPD patients is high，and positively associated with smoking index，the related departments should strengthen the smoking cessation propaganda. 2016 Vol. 23 (15): 20-22 [Abstract] ( 134 ) HTML (39 KB)  PDF  (0 KB)  ( 20 ) 23 Effect of Pulmonary rehabilitation combining with budesonide/formoterol and tiotroPium on treating stable-stage severe and extremely severe COPD LIU Han-kun;ZHOU Ming;WU Zhi-qiang Objective To explore the influence of pulmonary rehabilitation combining with budesonide/formoterol and tiotropium on pulmonary function and quality of life　（QOL）in patients with chronic obstructive pulmonary diseases （COPD）.Methods From July 2013 to December 2015，95 patients with severe and extremely severe COPD at a stable stage in our hospital were selected and randormly divided into group A，group B and group C.In group A（n=31），inhalation of budesonide/formoterol was used for treatment；In group B　（n=32），inhalation of budesonide/formoterol combining with tiotropium was adopted；In group C　（n=32），on the basis of the group B，pulmonary rehabilitation was added.Pulmonary function，Modified Version of the British Medical Research Council Respiratory Questionnaire　（mMRC），and 6-minute walking distance　（6-MWD）were detected before treatment and 3 months after treatment.The forced expiratory volume in one second　（FEV1），percentage of FEV1on predicted value，and FEV1/FVC were calculated.The changes of monitoring indexes before and after treatment among three groups were compared.Results After 3-month treatment，FEV1，percentage of FEV1on predicted value，FFEV1/FVC，mMRC，and 6-MWD were all improved among three groups compared with those before treatment，which were displayed statistical differences　（P＜0.05）；These indexes in group C were much better than those in group A and group B，which were displayed statistical difference among inter-group comparisons（P＜0.05）.Conclusion For patients with severe and extremely severe COPD at a stable stage，pulmonary rehabilitation combining with budesonide/formoterol and tiotropium has a better synergistic effect in comparison with that by budesonide/formoterol or budesonide/formoterol and tiotropium，which greatly improves patient′s pulmonary function and QOL and is worthy of promotion. 2016 Vol. 23 (15): 23-25 [Abstract] ( 125 ) HTML (40 KB)  PDF  (0 KB)  ( 33 ) 26 Surgical selection evaluation and effects comParison of 120 cases with cholecystectomy GAO Ye Objective To analyze the surgical selection evaluation and effects comparison of 120 cases with cholecystectomy.Methods 120 cholecystectomy patients from January 2014 to November 2015 in our hospital were discussed and analyzed.120 patients were arranged to a random number.With the number they were divided into laparoscopic group（n=60）and open surgery group（n=60）.Patients in laparoscopic group were given laparoscopic cholecystectomy and patients in open surgery group were treated with open cholecystectomy.Postoperative situation and clinical treatment effects between two groups were compared.Results The postoperative total effective rate，postoperative evacuation time and hospitalization expense in laparoscopic group and open surgery compared with no statistical differenc（P＞0.05）.The bleeding volume during operation，operation time，hospital staying，pain relievers using and incidence rate of complications in laparoscopic group were less than open surgery group with statistical difference（P＜0.05）.Conclusion The effects and hospitalization expense has no obvious difference between laparoscopy group and open surgery group，but the complications more easily appeared in open surgery group than laparoscopy group with longer hospital staying. 2016 Vol. 23 (15): 26-28 [Abstract] ( 123 ) HTML (34 KB)  PDF  (0 KB)  ( 24 ) 29 Clinical study of reduced glutathione in treating diabetes drug induced liver injury in the elderly Patients ZHOU Xiao-ping Objective To explore the clinical effects of reduced glutathione in diabetes drug induced liver injury in the elderly patients.Methods 62 elderly diabetes patients with drug induced liver injury from January 2012 to December 2014 of our hospital were selected and were randomly divided into treatment group and control group.Each group was 31 cases.Patients in control group were given routine treatment，and patients in treatment group were given intravenous infusion reduced glutathione injection 1.2 g into saline 150 ml once a day，for 6 weeks on the basis of control group.The cure rate and incidence of adverse reaction between two groups were compared.Results The cure rate in treatment group was 87.1%，higher than 64.5%in control group with statistical difference（P＜0.05）.The incidence of adverse reactions between the two groups had no statistical differenc（P＞0.05）.Conclusion Reduced glutathione can enhance the cure rate and decrease the rate of turn into chronic liver disease of elderly diabetes patients with drug induced liver injury. 2016 Vol. 23 (15): 29-31 [Abstract] ( 135 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 32 Study of the differences of extravascular lung water index in the Patients with Pulmonary edema induced by different causes of disease WU Shou-kun;WU Yi;LUO Wen-xiao;ZHENG Zhi-zhong;TAN Xian-nian Objective To study the differences of EVLWI in the patients with pulmonary edema induced by different causes of disease.Methods 75 patients with typical pulmonary edema who were admitted to the department of critical medicine in our hospital from January 2014 to June 2015 were selected.They were assigned to two groups according to different causes of disease，namely acute cardiogenic pulmonary edema group（ACPE group）of 44 patients and acute respiratory distress syndrome group（ARDS group）of 31 patients.The difference of EVLWI in both groups and the relationship between EVLWI and prognosis were analyzed.Results MAP，HR，CI，EVLWI，PVPI in ACPE group was significantly lower than that in ARDS group respectively，CVP and OI in ACPE group was significantly higher than that in ARDS group respectively（P＜0.05）；OR values of MAP，CVP，OI，CI and PVPI was respectively＞1；In ACPE group，OR value of PVPI was up to 4.33 maximally，and in ARDS group，OR value of PVPI was up to 4.21 maximally.The risk of PVPI for EVLWI in both groups was higher；The mortality rate in ACPE group was 6.82%，significantly lower than 25.81%in ARDS group（P＜0.05）；The death and survival EVLWI values at 0，24 and 72 h in both groups was respectively higher than the normal value.The death and survival EVLWI values at 0 and 24 h in ACPE group was respectively significantly lower than that in ARDS group，and EVLWI value at 72 h was significantly higher than that of ARDS group（P＜0.05）；Survival and death EVLWI in ACPE group was dynamically monitored respectively，and survival EVLWI was in a decreasing trend and death EVLWI was in an increasing trend.Survival and death EVLWI in ARDS group was dynamically monitored respectively and they were both in a decreasing trend.Conclusion The influencing factors for EVLWI include MAP，CVP，OI，CI and PVPI.ACPE and ARDS patients show significant differences in EVLWI.The mortality rate of patients with pulmonary edema induced by different causes of disease also have differences.Therefore，different causes of pulmonary edema is determined via clinical testing of patients′EVLWI levels，which is of great significance in predicting prognosis and performing individualized treatment for the patients. 2016 Vol. 23 (15): 32-34转37 [Abstract] ( 135 ) HTML (42 KB)  PDF  (0 KB)  ( 11 ) 35 APPlication value of dynamic electrocardiogram in silent myocardial ischemia YU Feng-hua Objective To study the application value of dynamic electrocardiogram in clinical diagnosis silent myocardial ischemia（SMI）.Methods 140 patients from September 2014 to September 2015 of our hospital were selected.The SMI patients were divided into observation group and control group according to random number table，and each group was 70 cases.Patients in control group were used routine electrocardiogram for examination，and patients in observation group were used dynamic electrocardiogram for examination.The detection rate in two groups and dynamic electrocardiogram monitoring results in observation group were analyzed.Results The detection rate in observation group was 94.28%，higher than 68.57%in control group，and the detection rate between two groups had statistical significance（P＜0.05）.Silent myocardial ischemia occurred total of 641 times，heart rate more than 100/min counted for about 374 times （58.35%）；heart rate between 65 to 100/min counted for about 175 times（27.3%）；heart rate less than 65/min counted for about 92 times（14.35%），the incidence of myocardial ischemia had positive related with heart rate.The silent myocardial ischemia occurred 641 times，the percentage of myocardial ischemia among four times were respectively 48.83%，10.61%，19.97%and 20.60%.The incidence of myocardial ischemia in the period from 6：00 obviously higher than other periods with statistical significance（P＜0.05）.Conclusion Using dynamic electrocardiogram in clinical monitoring silent myocardial ischemia，can identify silent myocardial ischemia early，which enhances the detection rate of silent myocardial ischemia and has great meaning for the treatment of silent myocardial ischemia. 2016 Vol. 23 (15): 35-37 [Abstract] ( 134 ) HTML (35 KB)  PDF  (0 KB)  ( 37 ) 38 Clinical study of tissue-selecting theraPy staPler combined with extemal hemorrhoidectomy in treating severe mixed hemorrhoids WANG Hong-xu Objective To observe the clinical effects of tissue-selecting therapy stapler（TST）combined with extemal hemorrhoidectomy in treating severe mixed hemorrhoids.Methods 156 mixed hemorrhoids patients from July 2014 to August 2015 of our hospital were selected as study objects.The patients were divided into observation group and control group.Each group was 78 cases.Patients in observation group were used TST combined with extemal hemorrhoidectomy，and patients in control group were used procedure for prolapseand hemorrhoids（PPH）.The treatment effects and incidence rate of complications in two groups were compared.Results The cure number of observation group was 72 and the cure rate was 92.31%，obviously higher than that was 80.77%in control group with statistical difference（P＜0.05）.The operation time of observation group was shorter than that of control group，bleeding volume during operation was less than that of control group and VAS score of observation group were obvious lower than that of control group，with statistical difference（P＜0.05）.The four complications incidence liked anal pendant expansion，anorectal stenosis，abnormal bleeding and edema of anal edge，the total incidence rate of complications in observation group was 15.38%，far lower than 46.15%in control group，with statistical difference（P＜0.05）.Conclusion TST combined with extemal hemorrhoidectomy has more ideal clinical effects than PPH treatment，which can obviously decrease complications and is worth to popularize in clinic. 2016 Vol. 23 (15): 38-40 [Abstract] ( 143 ) HTML (37 KB)  PDF  (0 KB)  ( 30 ) 41 Safety and efficacy of Dezocine combined with RoPivacaine for maternal ePidural labor analgesia during all stages ZHOU Xin-mei;WANG Shi-hong;HUANG Yuan-fang Objective To explore Dezocine combined with Ropivacaine in the efficacy and safety of maternal epidural labor analgesia during all stages.Methods Our hospital from June 2014 to October 2015 admissions of 300 cases of natural childbirth young mothers，with classification forⅠ-Ⅱ level by ASA.In accordance to their will，the childbirth young mothers were randomly divided into observation group and control group，150 cases in each group.The observation group patients were treated with Ropivacaine combined with Dezocine analgesia drugs.The control group patients were given Dezocine in drug delivery analgesia.The duration of labor，maternal pain，section palace yield，maternal use oxytocin，instrumental delivery and neonatal Apgar score and post natal maternal adverse reaction of the two groups childbirth young mothers were incidence statistics and analysis.Results The duration of labor in the observation group was significantly shorter than that in the control group　（P＜0.05）.The pain degree after 8 h of the observation group was significantly lower than that of the control group　（P＜0.05）.The rate of cesarean section in observation group was significantly lower than that of control group　（P＜0.05）.In the observation group，maternal use of oxytocin，instrumental delivery and neonatal Apgar score with that of the control group had no significant difference　（P＞0.05）.There was no significant difference in the incidence of adverse reactions between the two groups childbirth young mothers（P＞0.05）.Conclusion Dezocine combined with Ropivacaine for maternal epidural labor analgesia during all stages has a good clinical effect，and significant relationship maternal labor time and cesarean section rate，increase the rate of maternal safety，and it is worth popularizing in clinic. 2016 Vol. 23 (15): 41-43 [Abstract] ( 121 ) HTML (36 KB)  PDF  (0 KB)  ( 39 ) 44 Anesthetic effect of iliohyPogastric or ilioinguinal nerve block in Pediatric inguinal region surgery LIU Shu-xian;HU Hong-dong;ZHENG Xiao-ling;FENG Zhi-yong;LIANG Gao-wei Objective To report the anesthetic effect of iliohypogastric or ilioinguinal nerve block in pediatric inguinal region surgery.Methods A total of 120 pediatric patients from March to December in 2015 were randomly divided into two groups　（n=60）：IINB groupand Caudal block group，IINB group received 1%lidocaine and 0.15%ropivacaine at 0.3-0.5 ml/kg，Caudal block group received 1%lidocaine and 0.15%ropivacaine at 0.8 ml/kg.The vital signs of mean arterial pressure　（MAP）and heart rate　（HR）were recorded in four time points during surgery：the time of nerve block （T1），the skin incision（T2），ligating hernial sac（sheath dcs）（T3），waking time（T4），intraoperation and postoperation adverse events，the total dosages of propofol，the recover time from anesthesia，surgery time were also recorded，Face legs activity cry consolability（FLACC）score was used to assess the pain score postoperatively at 2，4，6 h postoperation respectively. Results In IINB group，the difference of MAP、HR were no statistical significance　（P＞0.05）.In Caudal block group，MAP at T2，T4，and HR at T4were higher than those at T1，the differences were statistical significance（P＜0.05）；MAP at T3，HR at T2were significantly higher than those at T1，the differences were significantly statistical significance（P＜0.01）.MAP at T3，T4，and HR at T2in IINB group were significantly lower than those in Caudal block group　（P＜0.01），HR at T3，T4in IINB group were lower than those in Caudal block group　（P＜0.05），the adverse events in IINB group were significantly less，the recover time from anesthesia in IINB group were significantly shorter than those in Caudal block group　（P＜0.01），the total dosages of propof'ol in IINB group were less than those in Caudal block group（P＜0.05），the FLACC pain scores at 4 h postoperation in IINB group were lower than those in Caudal block group（P＜0.05），the FLACC pain scores at 6 h postoperation in IINB group were significantly lower than those in Caudal block group（P＜0.01）.Conclusion The anesthetic effect of IINB is better for inguinal region surgery in pediatrics，the anesthetic method of IINB has clinical value and it′s worthy of spreading to clinical application. 2016 Vol. 23 (15): 44-46转50 [Abstract] ( 141 ) HTML (44 KB)  PDF  (0 KB)  ( 24 ) 47 Sedation effect observation of Midazolam combined with hyPnotheraPy under ePidural anesthesia in oPeration in elderly Patients ZENG Mu-lan;WU Zhi-guo;LIN Jun;SONG Xiao-mei Objective To explore the sedation effect of Midazolam combined with hypnotherapy under epidural anesthesia in elderly operation.Methods 90 elderly men with inguinal hernia repair under epidural anesthesia in our hospital from January 2012 to December 2014 were randomly divided into three groups（each group was 30 cases）：group 1 was given hypnotherapy for treatment；group 2 was given Midazolam combined with hypnotherapy for treatment，and group 3 was given Midazolam for treatment.The SCL-90 factor scores anxiety，SBP，DBP，HR，SpO2，RR，Narcotrend，recovering time，numbers of adverse effects，intervention numbers during operation，drug treatment cases，and amnesia degree of patients in groups at entering the room，before intervention，after intervention and leaving room were recorded.Results After intervention，the difference of SBP，DBP，HR，SpO2，RR，Narcotrend，SCL-90 factor scores anxiety and amnesia degree of patients in group 2 had statistical significance compared with group 1 and group 3　（P＜0.05）.The difference of recovering time，drug treatment cases，numbers of adverse effects and intervention numbers during operation in group 3 had statistical significance compared with group 1 and group 2　（P＜0.05）.Conclusion Midazolam combined with hypnotherapy under epidural anesthesia in elderly operation with better sedation effects and decreases the risk of respiratory depression and hypotension. 2016 Vol. 23 (15): 47-50 [Abstract] ( 137 ) HTML (46 KB)  PDF  (0 KB)  ( 8 ) 51 APPlication effect of Dexmedetomidine and Oxycodone Hydrochloride Preventive analgesia in thoracoscoPe short oPeration HAO Xiao-yan;WANG Hui;WANG Wei Objective To explore the application effect of Dexmedetomidine and Oxycodone Hydrochloride preventive analgesia in thoracoscope short operation.Methods 60 patients，elective conducted thoracoscope surgery in our hospital，from November 2014 to November 2015 were selected and were random divided into two groups，experimental group and control group.Patients in experimental group were given Dexmedetomidine 1 μg/kg and Oxycodone Hydrochloride 0.1 mg/kg intravenous infusion slowly after anesthesia and before skin incision.Patients in control group were given correspondence saline.The blood pressure，heart rate，pulse oxygen saturation，breathing recovery time，eye opening time，pull out time of the endotracheal tube and the incidence rate of adverse effects liked nausea and vomiting at before anesthesia induction（T0），end of the surgery（T1），extubation（T2），30 minutes after extubation（T3），2 h after extubation（T4）and 4 h after extubation　（T5）in two groups were respectively compared.The postoperative sedation scores　（Ramsay）and visual analogue scale　（VAS）at T3，T4and T5were evaluated.Results The SBP，DBP and HR of patients in two groups had no statistical significance　（P＞0.05）；from T2to T5，SBP，DBP and HR in control group increased obviously，and had obvious difference with experimental group　（P＜0.05）；from T3to T5，the VAS score in experimental group was obvious lower than that in control group，while Ramsay score was higher than that in control group，and the difference was obvious（P＜0.05）. Conclusion Dexmedetomidine and Oxycodone Hydrochloride preventive analgesia in thoracoscope short operation can alleviate postoperative pain and agitation，with stable circulation and not increase the incidence rate of adverse effects liked nausea and vomiting.It is worth to popularize and application. 2016 Vol. 23 (15): 51-53转68 [Abstract] ( 137 ) HTML (42 KB)  PDF  (0 KB)  ( 33 ) 54 Contrast-enhanced ultrasound in the diagnosis and differential diagnosis of hePatic focal liver lesion HUANG Yu-hong;CHEN Wei-jun;LIANG Yan-yan Objective To explore the contrast-enhanced ultrasound in the diagnosis and differential diagnosis of hepatic focal liver lesion.Methods 34 patients who conducted routine ultrasound examination from January 2014 to January 2016 in our hospital were selected，and a total of 41 space-occupying lesions.41 lesions were divided into two groups according to pathological findings.17 malignant lesions were divided into observation group，and 24 benign lesions were divided into control group.The results of routine ultrasound and contrast-enhanced ultrasound examination were compared with pathological findings.The sensitivity，specificity and accuracy of all examinations were compared.Time-intensity curve was used to further identify the malignant or benign of focal liver lesion.Results The sensitivity，specificity and accuracy of contrast-enhanced ultrasound in diagnosis focal liver lesion were respectively 87.5%，95.5%and 85.4%，which were respectively 61.1%，84.2%and 65.9%in routine ultrasound，and the difference was statistical significance when compared with two groups（P＜0.05）.All of beginning enhanced time，time to peak，washout time，peak intensity quantitative values，benign lesions and malignant lesions record values had statistical significance when compared（P＜0.05）.Conclusion Contrast-enhanced ultrasound obvious enhance the sensitivity，specificity and accuracy of ultrasound for focal liver lesion and contrast-enhanced ultrasound has great value in identification the benign and malignant lesions by analysis quantitative parameters change of time-intensity curve. 2016 Vol. 23 (15): 54-56 [Abstract] ( 118 ) HTML (35 KB)  PDF  (0 KB)  ( 25 ) 57 Imageology character of chondroblastoma LIU Jing;ZHAN Wei;JIAO Jun;LIAO Xin Objective To explore the imageology character of chondroblastoma.Methods The data of 15 chondroblastoma patients，confirmed by pathology，from January 2010 to December 2015 of hospital affiliated to Guizhou university of medical sciences were selected.The imageology character was summarized.Results Among 15 cases，13 cases appeared in long bone epiphysis　（8 cases were shinbone，4 cases were femur and 1 was humerus）；1 appeared in patella and 1 appeared intalus bone.The imageology character was mainly of quasi-circular，boundary clear dilatability bone destruction area（X-ray and CT in low density，MRI in a bit long T1 and length mixed T2 signal），visible lesions internal calcifications and hardening of the edge.Conclusion Careful analysis the imaging characteristics of chondroblastoma can enhance the imaging diagnostic level of this disease，help clinical diagnosis as soon as possible and understand the recurrence，transfer and malignancy. 2016 Vol. 23 (15): 57-59 [Abstract] ( 134 ) HTML (42 KB)  PDF  (0 KB)  ( 37 ) 60 APPlication value of B ultrasound combined with ECG in diagnosis of hy-Pertensive heart disease YAN Zhi-yi;WU Hui-shuang;CHE Li-li;XIE Jie-yi Objective To discuss the application value of B ultrasound combined with ECG in diagnosis of hypertensive heart disease（HHD）.Methods 336 HHD patients treated in our hospital from December 2012 to December 2015 were selected，according to the different methods of diagnosis was divided into B ultrasound combined ECG（group A），single use of B ultrasound（group B），and single use of ECG（group C），112 cases in each group，and the diagnostic effects and application value of three groups were compared and analyzed.Results As to detection of left ventricle hypertrophy and left ventricular volume dilation，the effect in group A was significantly superior to those in group B and group C　（P＜0.05）；and the positive rate was significantly higher in group A（76.79%）than in group B（59.82%）and group C（51.79%）（P＜0.01）.Conclusion The effect of B ultrasound combined with ECG is more favorable than single use of B ultrasound or ECG in diagnosis of hypertensive heart disease，with higher positive rate，which is of great clinical value and is worthy to be promoted. 2016 Vol. 23 (15): 60-62 [Abstract] ( 145 ) HTML (37 KB)  PDF  (0 KB)  ( 30 ) 63 APPlication of dual-source CT"double low"technology in head and neck CTA ZHANG Da-bo;JIANG Mei;XIE Jing-wen;FENG Liu Objective To explore the application of dual-source CT"double low"technology in head and neck CTA. Methods 120 patients were suspected to have the head and planed to conduct neck vascular lesions and head and neck CTA examination，were divided into two groups.Patients in observation group were given double low technology and patients in control group were given routine CT technology.All data of patients in two groups were compared and analyzed.Results The CT volume dose index（CTDIvol），dose length product（DLP），effective dose（ED）and total iodine in observation group were lower than that of control group，and the difference was statistical significance　（P＜0.05）；Compared with standard deviation，the CT value in carotid artery bifurcation and sternocleidomastoid muscle in two groups had no statistical significane（P＞0.05）；Comparison the SNR and CNR in two groups showed the difference had no statistical significance（P＞0.05）.Conclusion Using dual-source CT"double low"technology for image not only can be used in clinical diagnosis，but also with high safety，which is worth to popularize in clinic. 2016 Vol. 23 (15): 63-65 [Abstract] ( 128 ) HTML (36 KB)  PDF  (0 KB)  ( 31 ) 66 Diffusion weighted magnetic resonance imaging in diagnosis and differential diagnosis of hePatocellular carcinoma SUN Yong-hua;CHEN Jiang;LIANG Zhi-gang Objective To investigate the effect of magnetic resonance diffusion weighted imaging in the differential diagnosis of liver cancer.Methods The 85 patients with occupying lesions in our hospital from June 2013 to May2015 in our hospital were selected，including 28 cases of primary hepatocellular carcinoma，30 cases of hepatic hemangioma，15 cases of metastatic tumor，12 cases of hepatic cyst，They were scanned by diffusion weighted magnetic resonance imaging，the ADC value and ADC value of different liver lesions with different b values were compared.Results The ADC values of different liver lesions were decreased with the increase of b value，The ADC value of primary liver cancer was significantly lower than that of hepatic hemangioma，metastasis and hepatic cyst，the difference was statistically significant（P＜0.05）；The b value difference was more close to the actual value of DC，and the fluctuation was small. Conclusion Quantitative analysis of ADC value by MR diffusion weighted imaging can improve the diagnosis and differential diagnosis of hepatocellular carcinoma. 2016 Vol. 23 (15): 66-68 [Abstract] ( 135 ) HTML (37 KB)  PDF  (0 KB)  ( 29 ) 69 Clinical efficacy and safety evaluation of doxycycline joint clindamycin for Mycoplasma infection of female genital tract BAO Hai-yan;WANG Duo;ZHENG Xiang-yang Objective To investigate the clinical efficacy and safety evaluation of doxycycline joint clindamycin for Mycoplasma infection of female genital tract.Methods 129 cases with Mycoplasma infection of female genital tract were divided into treatment group（65 cases）and control group（64 cases）by different treatments in our hospital department of gynaeology from January 2013 to October 2014.The treatment group were given doxycycline by oral joint clindamycin by intrarenous，while the control group were given doxycycline alone.Curative effect of two groups were observed and safety were evaluated.Results The total effective rate was 96.92%in the treatment group，higher than 79.69%in the control group，the difference between the two groups was statistically significant（P＜0.05）.The adverse events occurred in patients of the treatment group was 15.38%，compared with 14.06%in the control group，the difference between the two groups was not statistically significant（P＞0.05）.Conclusion For Mycoplasma infection of female genital tract，the treatment of doxycycline joint clindamycin has a better clinical efficacy and safety. 2016 Vol. 23 (15): 69-71 [Abstract] ( 150 ) HTML (36 KB)  PDF  (0 KB)  ( 42 ) 72 Efficacy of clinical Pharmacy intervention on comPliance and curative effect of Patients with hyPerliPidemia JIA Yan-li;YU Li;YU Zhen-lan Objective To study the compliance and clinical efficacy of clinical pharmacy intervention in patients with hyperlipidemia.Methods 240 cases of hyperlipidemia patents in our hospital from October 2012 to October 2014 were selected，and the patients were randomly divided into observation group of 120 cases and control group of 120 cases. The patients in the observation group were treated with clinical pharmacy，at the same time the control group were treated by blank clinical pharmacy intervention.After and before the intervention，drug compliance score，the level of TC，TG，HDL-C and LDL-C were compared between the two groups.The statistical analysis was treated.Results The medication compliance score of the observation group was significantly higher than before the invention on clinical pharmacy（P＜0.05）.Compared with the same period of the control group，it was also significantly improved（P＜0.05）.After the intervention the TG and LDL-C were significantly decreased than before（P＜0.05）.Compared with the control group，the observation group patients were much lower on the TC，LDL contrast.Conclusion The effect of the clinical pharmacy intervention on the hyperlipidemia and blood lipid levels are significantly improved，which can improve the patient′s medication process，improve the clinical effects and is very important to the clinical medical work. 2016 Vol. 23 (15): 72-74 [Abstract] ( 126 ) HTML (38 KB)  PDF  (0 KB)  ( 33 ) 75 ComParison efficacy of amiodarone and lidocaine in the treatment of acute myocardial infarction combined with ventricular arrhythmia LI Xian-liang;JIANG Xian-yan;CUI Mei-ping;JIANG Wen-bin;GUO Xiao Objective To analyze the efficacy of amiodarone and lidocaine in patients with acute myocardial infarction （AMI）combined with ventricular arrhythmia.Methods From March 2013 to March 2015，120 patients with AMI and ventricular arrhythmia treated in our hospital were selected as research objects.They were divided by a random number table.In lidocaine group，lidocaine via intravenous injection was used，while in amiodarone group，patients were treated with amiodarone.The clinical effect and occurrence of adverse reactions after different medications between the two groups were compared.Results After different medications，the total effective rate in the amiodarone group was 93.33%，much higher than that in the lidocaine group accounting for 68.33%，with a statistical difference（P＜0.05）.In the amiodarone group，the fatality rate was 3.33%lower than that in the lidocaine group accounting for 8.33%.The incidence of adverse reactions in center，intra and extra-heart blood vessels in the process of intravenous dripping of amiodarone was 16.67%，while in the lidocaine group，the incidence of adverse reactions was 6.67%with non-obvious difference，which was not displayed a statistical significance（P＞0.05）.Conclusion For patients with AMI and ventricular arrhythmia，amiodarone and lidocaine are provided separately for treatment，and clinical efficacy is remarkable after using amiodarone with few adverse reactions. 2016 Vol. 23 (15): 75-77 [Abstract] ( 138 ) HTML (39 KB)  PDF  (0 KB)  ( 21 ) 78 Clinical effect of tongxinluo caPsule combined with nimodiPine and oxiracetam on vascular cognitive imPairment ZOU Wei-hui;WU Mei-quan;HUANG Guo-dong Objective To investigate the clinical effect of tongxinluo capsule combined with nimodipine and oxiracetam on vascular cognitive impairment（VCI）.Methods 120 patients with VCI in our hospital from September 2013 to June 2015 were randomly divided into observation group（n=60）and control group（n=60）.Patients in control group were treated with nimodipine and oxiracetam.Patients in observation group were treated with tongxinluo capsule combined with nimodipine and oxiracetam.After a six months course of treatment，the clinical curative，the score of minimum mental state examination（MMSE），activity of daily living scale and adverse reaction incidence were compared between two groups.Results Total efficiency of the control group was 43.1%，lower than 71.7%in the observation group.There was significant difference between the control group and the observation group about the clinical effect（P＜0.05）.About the score of MMSE and activity of daily living scale there were no significant differences before treatment between two groups（P＞0.05），while after treatment there were significant differences（P＜0.05）.There were significant differences between before and after treatment about the score of MMSE and activity of daily living scale in two groups respectively （P＜0.05）.The two groups had no significant adverse reactions.Conclusion Tongxinluo capsule combined with nimodipine and oxiracetam is safe and effective in the treatment of VCI and worth of being popularized. 2016 Vol. 23 (15): 78-80转83 [Abstract] ( 136 ) HTML (42 KB)  PDF  (0 KB)  ( 19 ) 81 Effects study of using leuProrelin acetate microsPheres before laParoscoP-ic surgery treatment of ovarian endometriomas LI Pei-ying;CHEN Jian-hua;YIN Wan-ping;XU Hu-yun;LI Xu-ping;LI Zi-lin Objective To explore the clinical application effects of using leuprorelin acetate microspheres before laparoscopic surgery treatment of ovarian endometriomas.Methods 102 cases who diagnosed as ovarian endometriomas patients from January 2012 to July 2014 of our hospital were selected.Patients were average divided into control group and study group according to random method，and each group was 51 cases.All patients in two groups were given laparoscopic surgery.Patients in study group were given hypodermic injection leuprorelin acetate microspheres before operation，but patients in control group were given any treatment.Pelvic pain relief rate，recurrence rate，symptom relief rate，pregnancy rate and blood loss during operation in two groups were observed.Results The pelvic pain remission rate in study group was obvious higher than that of control group，and the difference was statistical significance（χ2=12.5269，P= 0.0004）；the recurrence rate in study group was obvious lower than that of control group，and the difference was statistical significance（χ2=7.4128，P=0.0065）；the pregnancy rate and symptoms remission rate in study group was obvious higher than that of control group respectively，and the difference was statistical significance（P＜0.05）；the average bleeding volume during operation in study group was less than that of control group，and the difference was statistical significance （t=9.7203，P=0.0000）.Conclusion Using leuprorelin acetate microspheres before laparoscopic surgery treatment of ovarian endometriomas with better effects，which can obviously enhance the symptoms remission rate and pregnancy rate，decrease bleeding during operation and is worth to popularize in clinical for its great clinical meaning. 2016 Vol. 23 (15): 81-83 [Abstract] ( 119 ) HTML (35 KB)  PDF  (0 KB)  ( 29 ) 84 The effect observation of thalidomide combined with cryotheraPy in the treatment of Prurigo nodularis ZOU Jin-bo;LU Tao;DU Xiao-lin;ZHANG Shu-ping Objective To observe the effectiveness of thalidomide combined with cryotherapy in the treatment of prurigo nodularis.Methods Altogether 54 cases of prurigo nodularis patients who had been treated in the hospital from January 2013 to June 2015 were selected and randomly divided into the observation group and control group with 27 cases in each group.Patients in observation group were treated with 50 mg，thalidomide 2 times per day.And 50 mg or 25 mg once daily was administered together with cryotherapy after symptoms were tapering off.The freezing and thawing could be performed repeatedly according to the size，thickness，position and local reactions of lesions.Patients in control group received oral desloratadine and were coated with compound flumetasone ointment.Results The effectiveness rate and recurrence rate of observation group was respectively 85.18%and 8.70%，44.44%and 41.67%in control group，with statistically significant differences between the two groups（P＜0.01，P＜0.05）.And there were no serious adverse reactions in both groups.Conclusion Application of combination of thalidomide and cryotherapy in the treatment of prurigo nodularis demonstrates its advantages in convenience，effectiveness and less adverse reactions，which is of great value in clinical application. 2016 Vol. 23 (15): 84-86 [Abstract] ( 110 ) HTML (37 KB)  PDF  (0 KB)  ( 7 ) 87 ComParison of analgesic and anti-Inflammatory effect of Resina Draconis generated by different artificial induction methods LUO Yu-dong;WU Yu-qiang;LI Ping;TAN An-qiang;ZHANG Qiang Objective To make an investigation on the comparison of analgesic and anti-inflammatory effects of Resina Draconis generated by different artificial induction methods.Methods The experimental data was derived from the laboratory of pharmaceutical factory of Guangxi University of TCM，which was collected in December 2015.The writhing test method was adopted in the analgesic test that recruited and divided 80 mice into 8 groups randomly and evenly with 10 mice in each group，including Saline Group，Aspirin Group　（0.5 g/kg），Large-Dosage Natural Group and Small-Dosage Natural Group（naturally-produced Resina Draconis with small dosage and with large dosage，1 g/kg and 2 g/kg），Large-Dosage Biological Group and Small-Dosage Biological Group　（biological-induction-produced Resina Draconis with small dosage and with large dosage，1 g/kg and 2 g/kg），Large-Dosage Chemical Group and Small-Dosage Chemical Group（chemicalinduction-produced　Resina　Draconis　with　small dosage and with large dosage，1 g/kg and 2 g/kg）.The drug was administered orally to mice in each group atthe dose of 0.1 ml/10 g，1 time a day，for 3 consecutive days，the effect of each drug on chemically-stimulated pain reactions（the number of writhing times，writhing latency and the inhibition rate）were observed.As for the anti-inflammatory test，50 mice were recruited and divided into 5 groups randomly and evenly with 10 mice in each group，including Control Group　（administered with the same volume of distilled water），Aspirin Positive Control Group　（0.2 g/kg），Natural Group（naturally-produced Resina Draconis，2 g/kg），Biological Group（biological-induction-produced Resina Draconis，2 g/kg）and Chemical Group　（chemical-induction-produced Resina Draconis，2 g/kg）.The drugs were continuously and intragastrically administered to all the mice one time a day，for 7 days.The right ears of all the mice were coated with 20 μl xylene 1 hour after the last administration to make all the mice′s right ears swelling.All the mice were killed 1 hour later and their ears were cut off.Then，the ear flaps were cut off with a 6 mm punch and weighed to calculate the weight gaps between the right ear and the left ear and observe the anti-inflammatory effect（the swelling degree of ears）.Results According to the writhing test results，the number of writhing times in Large-Dosage Natural Group and Small-Dosage Natural Group，Large-Dosage Biological Group and Small-Dosage Biological Group，Large-Dosage Chemical Group and Small-Dosage Chemical Group as well as Aspirin Group were（9.01±6.87），（10.05±7.87），（10.51±6.37），（11.05± 7.57），（10.39±7.35），（10.15±7.12），（10.00±4.57）times versus Saline Group′s of（21.10±10.62）times，which showed obvious inhibitory effects on the number of writhing times（P＜0.01）in all the groups except Saline Group.Large-Dosage Natural Group，Small-Dosage Natural Group，Large-Dosage Biological Group，Small-Dosage Biological Group，Large-Dosage Chemical Group and Small-Dosage Chemical Group demonstrated similarities with Aspirin Group in the analgesic effects（P＞0.05）.No significant difference was seen between the writhing frequency of Large-Dosage Natural Group，Small-Dosage Natural Group，Large-Dosage Biological Group，Small-Dosage Biological Group，Large-Dosage Chemical Group and Small-Dosage Chemical Group　（P＞0.05）.As for the anti-inflammatory experiment，the swelling degree of ears in Natural Group，Biological Group，Chemical Group，Aspirin Positive Control Group and Control Group were（7.8±2.3），（7.3± 2.6），（7.5±2.8），（7.0±2.2），（11.2±2.4）mg respectively，with the existence of significant difference between Control Group and the other four groups（P＜0.05）.There was no significant difference between the anti-inflammatory effect of Natural Group，Biological Group and Chemical Group　（P＞0.05）.Conclusion Resina Draconis generated by different artificial induction methods proves itself with no significant difference in anti-inflammatory and analgesic effects. 2016 Vol. 23 (15): 87-90 [Abstract] ( 104 ) HTML (45 KB)  PDF  (0 KB)  ( 27 ) 91 Pharmacoeconomics analysis on two kinds of carbaPenems antibiotics in treatment of severe Pneumonia GONG Ru-yan Objective To discuss the cost-effectiveness of two kinds of carbapenems antibiotics（biapenem and imipenem）in treatment of severe pneumonia.Methods 80 patients with severe pneumonia treated in our hospital from September 2012 to September 2015 were selected and randomly divided into observation group and control group，each with 40 cases.Patients in the observation group were given biapenem，while pateints in the control group were given imipenem，both for 10 days.The clinical effects were assessed and treatment costs were confirmed in two groups.The cost-effectivenesses were compared.Results The overall response rates were similar in both groups，which was 92.5% in the observation group and 95.5%in the control group without significant difference（P＞0.05）.The cost was 4797 yuan in the observation group，while it was 9630 yuan in the control group.The cost-effectiveness was lower in the observation group than in the control group（P＜0.05）.Conclusion The clinical effects of biapenem and imipenem are favorable in treatment of severe pneumonia，and the cost-effectiveness of biapenem is lower than that of imipenem. 2016 Vol. 23 (15): 91-93 [Abstract] ( 145 ) HTML (39 KB)  PDF  (0 KB)  ( 30 ) 94 Clinical analysis on methods of Sugan Huoxue with Huashi in the treat-ment of endometriosis CAO Yi-jun;XU Mei-yan;ZHONG Yun-lan Objective To explore the clinical effect on methods of Sugan Huoxue with Huashi in the treatment of endometriosis.Methods 70 cases of endometriosis in our hospital from January 2012 to August 2015 were selected and randomly divided into the treatment group and the control group，35 cases in each group.The control group was given gestrinone，the treatment group was given Sugan Huohua decoction of Sugan Huoxue with Huashi.The score of pain，the level of CA125 and PRL，the change of pelvic mass before and after treatment，the incidence rate of adverse reaction in the two groups was compared.Results The score of pain after treatment in the two groups was lower than that before treatment，with significant difference　（P＜0.01）.The score of pain after treatment in the treatment group was lower than that in the control group after treatment，with significant difference　（P＜0.01）.The diameter of the pelvic mass after treatment in the two groups was less than that before treatment，the level of CA125 and PRL after treatment in the two groups was less than that before treatment，with significant difference　（P＜0.05）.The was no significant difference in the diameter of the pelvic mass，the level of CA125 and PRL after treatment between the two groups（P＞0.05）.There was no obvious adverse reaction in the treatment group during the treatment period.Conclusion The effect of Shugan Huohua decoction of Sugan Huoxue with Huashi in the treatment of endometriosis is significant，it is worthy of clinical promotion and application. 2016 Vol. 23 (15): 94-96转102 [Abstract] ( 113 ) HTML (46 KB)  PDF  (0 KB)  ( 16 ) 97 Clinical effect of traditional Chinese medicine pharyngitis prescription in the treatment of acute pharyngitis LI Rui-lin;WANG Fang;ZHAO Fang;YANG Wei-zhuo Objective To explore the clinical effect of traditional Chinese medicine　（TCM）pharyngitis prescription in the treatment of acute pharyngitis.Methods 142 patients with acute pharyngitis in our hospital from March 2012 to July 2015 were selected and divided into the infection group and the mixed group according to body temperature and results of blood routine examination.Patients in the infection group were randomly divided into the infection treatment group and the infection control group，the infection treatment group was given cefaclor and TCM pharyngitis prescription，the infection control group was treated with single cefaclor.Meanwhile，patients in the mixed group were divided into the mixed treatment group and the mixed control group，the mixed treatment group was given TCM pharyngitis prescription，the mixed control group was treated with ribavirin.The effect of each group was compared.Results The total effective rate in the infection treatment group was 85.71%，which was higher than 64.86%in the infection control group，with significant difference（P＜0.05）.The total effective rate in the mixed treatment group was 94.12%，which was higher than 75.00%in the mixed control group，with significant difference（P＜0.05）.The decline range of body temperature of effective patient in the infection treatment group was better than that in the infection control group，with significant difference　（P＜0.05）.The decline range of body temperature of effective patient in the mixed treatment group was better than that in the mixed control group，with significant difference（P＜0.05）.There was no significant difference in the incidence rate of adverse reaction between all groups（P＞0.05）.Conclusion TCM pharyngitis prescription has reliable clinical effect in the treatment of acute pharyngitis，it is worthy of clinical promotion and application. 2016 Vol. 23 (15): 97-99 [Abstract] ( 108 ) HTML (43 KB)  PDF  (0 KB)  ( 9 ) 100 Long term effect analysis of modified Yanghe decoction in the treatment of knee osteoarthritis WU Zhi-hui;CHEN Shi Objective To explore the long term effect of modified Yanghe decoction in the treatment of knee osteoarthritis.Methods 144 knee osteoarthritis patients from December 2014 to December 2015 in our hospital were selected and randomly divided into the observation group and the control group，72 cases in each group.The control group was given routine clinical treatment，the observation group was given modified Yanghe decoction on the basis of the control group.The level of serum matrix metalloproteinase-3（MMP-3）and matrix metalloproteinase-9（MMP-9）before and after treatment，the effect after treatment for 12 months in the two groups was compared，the safety in the two groups was evaluated.Results The level of MMP-3 and MMP-9 after treatment in the two groups was lower than that before treatment，with significant difference（P＜0.05）.The level of MMP-3 and MMP-9 after treatment in the observation group was lower than that in the control group after treatment，with significant difference　（P＜0.05）.Excellent and good rate in the observation group was 91.67%，which was higher than 79.17%in the control group，with significant difference　（P＜0.05）.Both of the safety in the two groups was gradeⅠ.Conclusion Further given modified Yanghe decoction on the basis of routine treatment for knee osteoarthritis patients can obvious enhance long term effect and with good safety. 2016 Vol. 23 (15): 100-102 [Abstract] ( 104 ) HTML (39 KB)  PDF  (0 KB)  ( 37 ) 103 Protective effects of Mangholia officinalis on myocardial ischemia-rePerfusion injury in rats HU Yue Objective To investigate the effect and underlying mechanisms of Mangholia officinalis on myocardial ischemia-reperfusion injury　（MIRI）in rats.Methods Twenty-six healthy male SD rats were randomly divided into three groups：sham operation group（n=7），MIRI model group（n=10），drug group（n=9）.MIRI rat models were created by reperfusion for 120 min after ligaturing anterior interventricular branch of the left coronary artery for 30 min.Then the plasma and cardiac muscle tissue of six rats of each group were collected separately，and the activities of creatine kinase（CK）and myeloperoxidase（MPO）in plasma，superoxide dismutase（SOD）in myocardium were determined.Results Compared with sham operation group，the activity of CK of model group was decreased　（P＞0.05），the activity of MPO was increased obviously（P＜0.05），while the activity of SOD was decreased（P＜0.05）.Compared with model group，the activity of CK and MPO of drug group was decreased　（P＜0.05），while the activity of SOD was increased obviously（P＜0.05）.Conclusion Mangholia officinalis has a protective effct on MIRI in rats.Its mechanism is probably associated with resisting oxidation damage，reducing inflammatory reaction and increasing the supply of energy. 2016 Vol. 23 (15): 103-105 [Abstract] ( 103 ) HTML (39 KB)  PDF  (0 KB)  ( 12 ) 106 Protective effect of ulinastatin on liver mitochondrial function in mice infected by invasive Candida LI Xiao-yue Objective To discuss the protective effect of ulinastatin on liver mitochondrial function in mice infected by invasive Candida and its possible mechanism.Methods 60 male Kunming mice were given intraperitoneal injection of Candida albicans suspension after pretreatment by CTX and then made into models infected by invasive Candida and were randomly divided into control group（n=20），ulinastatin low-dose group（n=20），and ulinastatin high-dose group（n= 20）.Mice in the control group were given antifungal therapy，mice in the low-dose group were given antifungal drug combined with ulinastatin　（1×104U/kg），while mice in the high-dose group were given antifungal drug combined with ulinastatin　（5×104U/kg）.The survival rate，mitochondriopoiesis index，nitrosative stress index and hepatic pathology of three groups on the 7thday were observed.Results The 7thday survival rate was significantly higher in the high-dose group than that in the control group（70%vs 30%，P=0.011）.On the 7thday，the level of PGC-1α mRNA was significantly higher in the high-dose group than that in the low-dose group and the control group　（P＜0.05），the nitrosative stress index on the 7thday was significantly lower in the high-dose group than in the low-dose group and the control group （P＜0.05）.Congestion of hepatic sinusoid observed by light microscope on the 7thday was slighter in the high-dose group than that in the control group.Conclusion High dose of ulinastatin may protect the liver mitochondrial function and facilitate mitochondriopoiesis in mice infected by invasive Candida via inhibition of nitrosative stress. 2016 Vol. 23 (15): 106-108 [Abstract] ( 131 ) HTML (39 KB)  PDF  (0 KB)  ( 29 ) 109 ExPression and significance of CK5/6，P63 and CD10 in breast benign and malignant lesions ZHU Zheng-yan Objective To study the expression and significance of CK5/6，p63 and CD10 in breast benign and malignant lesions.Methods 242 patients with breast proliferative lesions in our hospital from January 2010 to December 2015 were selected，among whom 151 patients had UDH　（UDH group），54 patients ADH　（ADH group）and 37 patients DCIS （DCIS group）；26 patients had microinvasion　（DCIS accompanied with microinvasion group）；83 patients had non-special invasive cancer（non-special invasive cancer group）.Immunohistochemical Envison two-step method was applied to test the expression of CK5/6，p63 and CD10 in the specimen in each group.Results The expression of CK5/6 in UDH group was significantly higher than that in ADH group，DCIS group，DCIS accompanied with microinvasion group and non-special invasive cancer group，the differences were statistically significant（P＜0.05）；The expression differences of CK5/6 among ADH group and DCIS group，DCIS accompanied with microinvasion group，non-special invasive cancer group were statistically significant　（P＜0.05）.Successive positive expressions of p63 and CD10 in basement membrane in UDH group，ADH group and DCIS group were not different，they were not expressed in DCIS accompanied with microinvasion group and non-special invasive cancer group，there were statistical differences among UDH group，ADH group，DCIS group and DCIS accompanied with microinvasion group，non-special invasive cancer group（P＜0.05）.Conclusion The combined test of the three indicators of CK5/6，p63 and CD10 is favorable in identifying breast benign and malignant lesions. 2016 Vol. 23 (15): 109-111 [Abstract] ( 120 ) HTML (35 KB)  PDF  (0 KB)  ( 6 ) 112 ComParing analysis of LEEP Pathology diagnose and liquid-based cytology and bioPsy result of cervix LI You-heng;XU Hong;ZENG Xun Objective To explore the difference of pathology diagnose results among loop electrosurgical excision procedure（LEEP），liquid-based cytology test（LCT）and multi-point biopsy under colposcope.Methods 112 patients with cervix LEEP treatment were selected as study object.The difference of pathology diagnose results among LEEP，LCT and multi-point biopsy under colposcope were analyzed.Results The coincidence rate between LCT and LEEP was 72.32% （81/112）；The coincidence rate between multi-point biopsy under colposcope and LEEP pathology diagnose was 75.89%（85/112）.Compared the results among LEEP，LCT and multi-point biopsy under colposcope，the difference had obvious difference（P＜0.05）.2 cases of LCT showed that cervical high-grade squamous intraepithelial neoplasia and the biopsy result was negative，but pathology diagnose result of LEEP was CINⅡ.Conclusion The LCT cytological examination，the pathology results of multi-point biopsy under colposcope and LEEP have difference，CIN diagnosis of only relying on cytology result by clinicians are not sufficient；CIN has the feature of multifocal coexistence，microscopically multi-point biopsy has limits.When liquid-based cytology test is abnormal but biopsy is normal，cervical loop resection is appropriate. 2016 Vol. 23 (15): 112-114 [Abstract] ( 110 ) HTML (36 KB)  PDF  (0 KB)  ( 31 ) 115 Effect of batroxobin in treating flat tyPe sudden deafness and the imPact on fibrinogen LIU Hua-sen;TAN Guo-jie;WU Shao-guo;WU Li-mei;WANG Zhi;ZHU Feng Objective To study the effect of batroxobin in treating flat type sudden deafness and the impact on fibrinogen.Methods 83 flat type sudden deafness patients from February 2014 to December 2015 of our hospital were selected，and divided into routine group and batroxobin group by using random number table.Patients in routine group were treated with anti-virus，glucocorticoid，energy mixture.Patients in batroxobin group were further given batroxobin on the basis of routine group.The total effective rate and the difference of fibrinogen，mean of auditory threshold and blood viscosity before and after treatment were observed.Results Compared with routine group，the total effective rate in batroxobin group was higher，and the difference was statistical significance　（P＜0.05）；before treatment，the fibrinogen，mean of auditory threshold and blood viscosity were similar in two groups，and the difference was statistically significant（P＜0.05）；after treatment，the fibrinogen，mean of auditory threshold and blood viscosity in batroxobin group improved more than routine group，and the difference was statistical significance（P＜0.05）.Conclusion Batroxobin in treating flat type sudden deafness has obvious effect，which can improve the fibrinogen，mean of auditory threshold and blood viscosity effectively and is worth to popularize. 2016 Vol. 23 (15): 115-117 [Abstract] ( 123 ) HTML (37 KB)  PDF  (0 KB)  ( 36 ) 118 Clinical significance of correlation between blood Platelet count，Platelet volume，and serum Procalcitonin in neonatal sePsis LUO Lin;HUANG De-qiu;ZHANG Xu-ping;ZHOU Peng Objective To study the clinical application value of blood platelet count（PLT），mean platelet volume（MPV），and serum procalcitonin　（PCT）in neonatal sepsis.Methods From January 2014 to December 2015，80 neonates admitted into our hospital were selected as research objects and evenly divided into control group and experimental group in random.In the experimental group were included all neonates with sepsis，while in the control group were contained participants without infectious disease.The PLT，MPV and PCT in the two groups were detected and compared.Results Before treatment，the PLT was much lower and values of PCT and MPV were greatly higher in the experimental group compared with those in the control group with statistical differences　（P＜0.05）.After therapy，the value of PLT was increased following recovery of disease，while PCT and MPV were obviously decreased，which were displayed statistical differences（P＜0.05）.Conclusion Detection of PLT，MPV and PCT has certain application value on neonatal sepsis in clinic，which is worth of promotion. 2016 Vol. 23 (15): 118-120 [Abstract] ( 118 ) HTML (36 KB)  PDF  (0 KB)  ( 30 ) 121 Change and their clinical significance of serum Cys-C and urine NGAL levels in Patients with systemic luPus erythematosus ZHAO He-hong Objective To study the change of serum Cys-C and urine NGAL levels in patients with systemic lupus erythematosus（SLE）renal damage and their clinical significance.Methods 158 SLE patients treated in our hospital from October 2012 to October 2015 were selected as the study group，of which 116 patients were with lupus nephritis（LN），and 42 were without renal damage.All patients selected were in accordance with SLE diagnostic criteria revised by ACR in 2009.90 healthy volunteers were selected as the control group.The levels of serum Cys-C，urine NGAL，and conventional renal indexes including BUN and Cr were analyzed among three groups，and receiver operating characteristic （ROC）curve analysis was also conducted.Results The levels of serum Cys-C and urine NGAL were significantly higher in the study group than those in the control group（P＜0.01）.The levels of serum Cys-C and urine NGAL were significantly higher in the LN group than those in the non-LN SLE group　（P＜0.01），which showed that the application of serum Cys-C and urine NGAL was superior in early diagnosis of SLE to BUN and Cr.The result of ROC curve analysis showed that serum Cys-C combined with urine NGAL could achieve optimal sensibility　（90.52%）and specificity （96.21%）of diagnosis in renal damage of SLE，which was superior to single use of either of them.Conclusion Serum Cys-C and urine NGAL can be used as reliable indexes in early diagnosis of SLE renal damage.The combination of them can significantly enhance the sensibility specificity of LN diagnosis. 2016 Vol. 23 (15): 121-123 [Abstract] ( 122 ) HTML (36 KB)  PDF  (0 KB)  ( 37 ) 124 Clinical meaning of serum miR-1 in the early diagnosis of acute myocardium infarction ZHOU Zi-jian;CUI Xiu-ping;FENG Ke-qing;MA Kun Objective To study the early expression level of miR-1 in AMI patients and to explore the possibility and clinical meaning of it for the early diagnosis standard for AMI.Methods 40 AMI patients，40 anginal patients and 40 health people from July 2013 to July 2014 of cardiology department in our hospital were selected.The serum samples were collected at 1，2，6，12 and 24 hours after acute chest pain.The expression of serum miR-1，CK-MB and cTnI were tested by using RT-PCR.The relationship between serum miR-1，CK-MB and cTnI was analyzed.The clinical value of serum miR-1 expression level in early diagnosis AMI was explored.Results The relative expression level of serum miR-1 in AMI patients was 1.77±0.52，obvious higher than that were respectively 0.19±0.04 and 0.57±0.09 in health people and anginal patients　（P＜0.05）.After the onset of illness，the serum miR-1 increased fast and reached a peak around 12 h after the onset of chest pain；Pearson relevant analysis showed that serum miR-1 expression of AMI patients had positive relationship with CK-MB and cTnI（P＜0.05）.Conclusion MiR-1 in AMI patients with high expression，which can well reflect the AMI myocardial injury and can be a new measuring marker for AMI. 2016 Vol. 23 (15): 124-126 [Abstract] ( 127 ) HTML (40 KB)  PDF  (0 KB)  ( 38 ) 127 Clinical study of the relationshiP between tyPe O blood Pregnant women serum IgG antibody titer and hemolytic direare of newborn ZHI Hong-xia;ZHOU You-shu;ZOU Biao Objective To explore the relationship between type O blood pregnant women serum IgG antibody titer and hemolytic direare of newborn，and to provide value reference information for clinical diagnosis and treatment and study in the future.Methods 1350 type O blood pregnant women and newborns from January 2013 to December 2015 of our hospital were selected.Microcolumn gel Coombs test was used to test the titer of pregnant women serum IgG resisting A （B）antibodies and the statistic analysis was conducted for the test results.Results The results showed that among 1350 pregnant women serum，656 with IgG against A　（B）antibody titer from 1∶256 to 1∶1024 and the constituent ratio was 48.59%.With the increased of pregnant women serum IgG against A　（B）antibody titer，the incidence rate of newborn hemolytic direare increased　（P＜0.05）.The incidence rate of newborn hemolytic direare in parents combination of OAB blood type higher was than that of O-A or O-B combination　（P＜0.05）.Conclusion Testing type O blood pregnant women serum IgG antibody titer can provide reference basis for the prediction and early diagnosis of newborn hemolytic direare.It has obvious clinical value. 2016 Vol. 23 (15): 127-129 [Abstract] ( 124 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 130 Early diagnosis value of Procalcitonin and high-sensitivity C-reactive Protein in neonatal sePticemia HUANG Chang-e;LIU Yun-hua ;WANG Jia Objective To explore the value of procalcitonin（PCT）and high-sensitivity C-reactive protein（hs-CRP）in early diagnosis of neonatal septicemia.Methods From August 2014 to February 2016，200 neonates with sepsis admitted into our hospital were selected as research group，and another group of 200 neonates with non-infectious diseases during the same period was chosen as control group.The blood culture was regarded as golden standard.The blood culture，PCT and hs-CRP from serum in all participants were tested and outcomes were statistically analyzed.Results In the research group，proportion of positive PCT among 200 neonates was highest，and blood culture was in the second.The positive rate of hs-CRP was lowest.In the research group，the level and positive rate of serum PCT were both higher than those in the control group　（P＜0.05）.The level of hs-CRP in the research group was higher than that in the control group　（P＜0.05），but no statistical difference was displayed after comparing the positive rate of hs-CRP in both groups （P＞0.05）.Setting serum PCT≥0.5 ng/ml and hs-CRP≥8 mg/L as positive standard，the sensitivity，specificity，and accuracy of serum PCT on diagnosing neonatal septicemia were all higher than those by testing on hs-CRP（P＜0.05）.Conclusion Both PCT and hs-CRP have guiding significance on clinical diagnosis and treatment of neonatal septicemia，especially PCT can be considered as an important diagnostic and monitoring index on neonatal septicemia，which can play a vital clinical value on early diagnosis and treatment of neonatal sepsis. 2016 Vol. 23 (15): 130-132 [Abstract] ( 136 ) HTML (35 KB)  PDF  (0 KB)  ( 36 ) 133 Influence of community family doctor service model for diabetes，high blood Pressure Patients HUANG Chun-xuan;HU Yun-hong;XIE Yan-hua Objective To explore the influence of community family doctor service model for diabetes，high blood pressure patients.Methods 257 cases suffering from high blood pressure or diabetes patients in our community from January 2013 to December 2015 were selected and randomly divided into the control group（125 cases）and the observation group（132 cases）.Both groups were given their own drug treatment，the control group was only rested at home，the observation group was given community family doctor service model to intervene.The intervention effet in the two groups was compared.Results The rate of diet control，the related knowledge mastery，the regular use of drug and the movement after intervention in the observation group was higher than that in the control group respectively，with significant difference（P＜0.01）.The effective control rate of diabetes in the observation group was 97.22%，which was higher than 76.67% in the control group，with significant difference　（P＜0.05）.The effective control rate of blood pressure in the observation group was 94.79%，which was higher than 81.05%in the control group，with significant difference　（P＜0.01）.The level of fasting blood glucose，postprandial 2 hours blood glucose，blood pressure after treatment in the observation group was lower than that in the control group，with significant difference　（P＜0.01）.Conclusion Community family doctor service model can better serve diabetes，hypertension patients，improve the bad habits of patients，treatment effect and quality of life，it is worthy of clinical promotion and application. 2016 Vol. 23 (15): 133-136 [Abstract] ( 99 ) HTML (50 KB)  PDF  (0 KB)  ( 21 ) 137 roblems and countermeasures on general-on-call of sPecialized cardiovascular hosPital SUN Qian-ying;CAO Yi-jun;ZHAO Yue;LIU Yi-hua The problems exsisting in the administrative general-on-call of specialized cardiovascular hospital are pointed out through analyzing the characteristics of specialized cardiovascular hospital and the task of administrative general-on-call in hospital.The methods of carrying out general-on-call professionalism pilot，establishing collaboration of administrative general-on-call and nursing general-on-call，applying stationed system or making an appointment for consultation，strengthening the training of the staff，upgrading the informationization level can be used to improve the working efficiency and ensure the regular operation during nonworking hours，which will provide the basis for hospital to achieve the comprehensive and acuracy management. 2016 Vol. 23 (15): 137-139转143 [Abstract] ( 133 ) HTML (44 KB)  PDF  (0 KB)  ( 30 ) 140 ExPloration on the clinical aPPlication of the sunshine medicine electronic monitoring system in the county-level Public hosPital KUANG Pei-xia ObJective To explore the application of the sunshine medicine electronic monitoring system in the public hospitals at the county level.Methods The sunshine medicine control group and the sunshine medicine electronic monitoring system were established in the hospital in June 2014.The proportion of monthly consumption sum of antibiotics in the hospital in the total consumption sum of medication　（the proportion of antibiotics），the proportion of total medicine income in the total income of the hospital（the proportion of medicine），the proportion of consumption sum of expensive antibiotics　（unit price more than 50 yuan）in the total amount of antibiotics，the proportion of large prescription　（more than 200 yuan）in all the prescriptions　（the proportion of large prescriptions）were calculated and publicized.Results After application of the sunshine medicine electronic monitoring system in the hospital，the proportion of antibiotics and the proportion of medicine decreased from 24.8%and 38.8%in June 2014 to 15.2%and 34.8%in July 2015 respectively.The proportion of consumption sum of expensive antibiotics in the total amount of antibiotics decreased month by month from 31.62%in June 2014 to 14.33%in July 2015.The proportion of large prescriptions decreased month by month from 1.34%to 0.43%in the hospital，the average amount of prescriptions in outpatient department of the hospital decreased month by month from 61.9 yuan to 50.4 yuan.Conclusion Application of sunshine medicine electronic monitoring system in the hospital has achieved remarkable results in reduction of the irrational clinical medication. 2016 Vol. 23 (15): 140-143 [Abstract] ( 138 ) HTML (41 KB)  PDF  (0 KB)  ( 41 ) 144 APPlication of hosPital information system and Excel in the management of effect lasted consumable XU Qing-yun;ZHANG Cai-you;ZENG Chun-sheng;WANG Xiao-mao;YE Hong-mei Medical consumables play an irreplaceable role in the whole medical system.In order to ensure the security use of medical staff and patients，and avoid waste because of the improper management loss，it is particularly important to manage the effect lasted effective and scientific.According to the effective material management practices，the problems that exist in the material effect lasted management were found out and hospital information system was combined with the function of leading data export Excel and could clearly see that all the recent consumables and failure consumables in Excel.The confirmation table of effect lasted consumables was made and identity management was conducted to realize effect lasted consumables management standardization，which not only decrease labour intensity，enhance management effective，but also avoid the phenomenon of payment consumables past due or will be due to medical personnel or patients strict. 2016 Vol. 23 (15): 144-146 [Abstract] ( 111 ) HTML (39 KB)  PDF  (0 KB)  ( 31 ) 147 The aPPlication effect of resPonsibility system nursing teaching mode on the teaching of nursing students CHEN Cai-qing;TAN Zhang-hong;WU Hui-ping Objective To explore the application effect of the responsibility system nursing teaching mode on the teaching of nursing students，and in order to further improve the teaching effect of nursing students.Methods A total of 81 nursing students in our hospital from November 2014 to November 2015 were randomly divided into control group and observation group.The control group received the functional teaching mode，and the observation group received the responsibility system nursing teaching mode.The clinical knowledge and self evaluation results were compared between two groups.Results The theoretical examination，clinical practice，medical records，nursing patient communication，disease assessment and the total scores in the observation group after graduate from department were significantly higher than those in the control group（P＜0.05）.The self evaluation results of nursing students in observation group were better than those of in the control group　（P＜0.05）.Conclusion The responsibility system nursing teaching mode can ensure the nursing students in practice to master more solid clinical theory knowledge and skills in the process，improve nursing students′sense of self-identity and the quality of nursing teaching，it is simple and worth of clinical popularizing. 2016 Vol. 23 (15): 147-149 [Abstract] ( 123 ) HTML (34 KB)  PDF  (0 KB)  ( 20 ) 150 APPlication of GSP Practice teaching in course of Science of Pharmacy Administration LI Wei-nie;ZENG Yu;LI Guo-guo The course of Science of Pharmacy Administration is a required course of pharmacy and related major in medical colleges.Because of the involving knowledge of laws and regulations，pure theoretical teaching can appear the situation of abstract and hard to remember or rote memorization.In order to enrich the teaching means and enhance the teaching effect，GSP practice teaching has been applied in the teaching of the course.Students participate in drug purchase，check and accept，sales section and deal with actual drug problem，which can increase their interest in learning，consolidate theoretical knowledge and improve practical skills. 2016 Vol. 23 (15): 150-152 [Abstract] ( 106 ) HTML (39 KB)  PDF  (0 KB)  ( 5 ) 153 APPlication effects analysis of interactive teaching in clinical nursing teaching CHEN Chun-yan Objective To explore the application effects of interactive teaching on clinical nursing teaching.Methods 100 nursing students from July 2013 to June 2015 in our hospital were selected as study object by randomly sampling method and divided into observation group and control group，and each group was 50 cases.Students in control group were taught by traditional teaching method，and students in observation group were taught by interactive teaching.After practice，the satisfaction to teaching mode and effects of students and teachers were understood by using teachers and students mutual evaluation except assess arranged by nursing department according to teaching object.Results The theory examination scores and practice examination scores in observation nursing students were obvious higher than those in control group，and the difference was statistical significance　（P＜0.05）.The total satisficing score of teachers and departments in practice nursing to students in observation group was（92.9±5.4）scores，obviously higher than（81.3±9.4）scores in control group，and scores of learning initiative，self-confidence，learning ability，professional skills and self-discipline consciousness score had significance difference　（P＜0.05）；The satisfaction of nursing students to teaching mode and teachers in observation group was obviously higher than that in control group，and the difference was statistical significance（P＜0.05）.Conclusion Interactive teaching can promote the communication between teachers and students，enhance the teaching effects effectively，obviously increase the learning initiative，self-confidence，learning ability，professional skills and self-discipline consciousness of nursing students and with better satisfaction of nursing students to interactive teaching.It is worth to popularize. 2016 Vol. 23 (15): 153-155 [Abstract] ( 99 ) HTML (41 KB)  PDF  (0 KB)  ( 28 ) 156 How to strengthen the cultivation of undergraduates majoring in clinical Pharmacy WANG Wen-ya;RAO Jin-jun;LV Lin;WU Shao-yu Pharmacists are one of the important members of the medical team.They are also the most potential partners in medical team.At present，the education and training model about continuing education running parallelly in training clinical pharmacists have been initially established.But how to strengthen the clinical pharmacy students in the school culture is the emphasis and difficulty of the teaching reform in medical colleges.The author thinks that pay attention strengthening the training of love and communication skills，diversifying learning methods，carrying out case discussion as well as regular testing can be effective to strengthen the theoretical and practical ability of students. 2016 Vol. 23 (15): 156-158 [Abstract] ( 107 ) HTML (34 KB)  PDF  (0 KB)  ( 37 ) 159 ExPloration of Pharmacology teaching method for Promoting the formation of the students′research thinking ZHANG Qi;SONG Juan;YUAN Jia-xin;TIAN Hua;LI Li-bo;HAN Cui-yan;GUO Li-na;CUI Hong-xia With the social development，scientific research ability has become an important goal of talent cultivation in universities，and the formation of research thinking is the important foundation of scientific research ability.This paper briefly introduced the exploration and innovation of pharmacology teaching process on the three sides：teaching methods，teachers′scientific research quality and teaching content.Using the course import with scientific research story and heuristic teaching to improve teaching methods，strengthening the training of scientific research and reviewing literature to improve teachers′scientific research quality；optimizing the teaching content，improving the appraisal way，Eventually，making the formation of students′scientific thinking and the improvement of students′comprehensive quality. 2016 Vol. 23 (15): 159-161 [Abstract] ( 118 ) HTML (37 KB)  PDF  (0 KB)  ( 34 ) 162 ExPloration and Practice on medical biochemistry teaching for international students YI Fang;YANG Ying-xue;SONG Yong-yan Biochemistry is an important basic medical subject.To improve the medical biochemistry teaching for international students，we report our exploration and reflection based on the ten-year teaching experiences.The teaching strategy and methods are concluded，the teachers′ability，planning and preparation，teaching method，frequently asked questions and solutions are discussed，in order to improve and promote teaching quality. 2016 Vol. 23 (15): 162-164转168 [Abstract] ( 129 ) HTML (39 KB)  PDF  (0 KB)  ( 21 ) 165 Safety Problem and countermeasures study of nursing students in clinical Practice DENG Yi-zhi This article through understanding the main safety problems existing in the practice of nursing students，personal safety likes traffic，food，property and environment；the security problems of occupational protection likes sharp apparatus，physical and chemical，biology and medical operation safety are included.The root of safety problems are analyzed from students，training hospital and school three aspects，which are mainly as follows：weak mind of students，poor coping ability，lacking of professional skills，lacking of communication skills，lacking of safety knowledge and legal knowledge，lacking of self-protection consciousness，training hospital safety education and management is not enough，lacks of teachers′teaching consciousness，lacking of school safety management，and not enough attention to the occupational protection education.Establishing the long-term mechanism of occupational protective education by cooperation between colleges and universities，establishing scientific and effective mechanism of safety management，carrying out the intern safety education in omnibearing and pre-job training are used to build preventive mechanism of interns accident harm；Prior agreement，post negotiation，judicial process and insurance escort are used to establish mechanism for the interns accident treatment，which are designed to reduce and prevent the occurrence of safety accidents. 2016 Vol. 23 (15): 165-168 [Abstract] ( 98 ) HTML (55 KB)  PDF  (0 KB)  ( 37 ) 169 APPlication effects of Chinese medicine sPecialist medical record imPort—scene simulation method in traditional Chinese medicine nursing oPeration training of N1 grade nursing staff LU Xuan;GUO Yin-gui;LIU Ru-ya Objective To explore the application effects of Chinese medicine specialist medical record import—scene simulation method on traditional Chinese medicine（TCM）nursing operation training.Methods 80 in-service non Chinese college graduates N1 level of nursing staffs in 2015 of our hospital were selected and randomly divided into control group and observation group.Staffs in control group were used traditional training methods for operating training，and staffs in observation group were used Chinese medicine specialist medical record import—scene simulation method for operating training.The teaching effects in two groups were compared.Results The relevant theory of TCM knowledge and skills operation average score in observation nursing was respectively（93.5±3.5）scores and（94.5±4.2）scores，obviously higher than（75.2±4.3）scores and（77.0±5.7）scores in control group；The training effective rate of activity and initiative，teamwork skill，nurse-patient communication skills，disease observation ability and participate practical activities of students in observation group was respectively 90.00%，95.00%，87.50%，87.50%and 92.50%，obviously higher than respectively 77.50%，82.50%，80.00%，75.00%and 82.50%，all of the difference were statistical significance（P＜0.05）.Conclusion Using Chinese medicine specialist medical record import—scene simulation method in TCM nursing operation can stimulate students′interest in learning，improve the theory and skill level of nursing staff in TCM operation and has an important role in the training of the ability of nursing staff in clinical work. 2016 Vol. 23 (15): 169-171转175 [Abstract] ( 133 ) HTML (40 KB)  PDF  (0 KB)  ( 27 ) 172 APPlication of video cliP education in reduction of occuPational exPosure of obstetrical interns FENG Li-ping;LI Yun-bo;TANG Shi-xiao Objective To discuss the application value of video clip education in reduction of occupational exposure of obstetrical interns.Methods 96 interns of our department from January to December 2015 were selected and randomly divided into control group and observation group.Interns in the control group were mainly educated by lectures as to occupational exposure education，while interns in the observation group were additionally educated by video clips，including types，common reasons，hazards and prevention of occupational exposure.The awareness rate of occupational exposure knowledge，implementation rate of self-protection against occupational exposure，and rate of occupational exposure were compared between two groups.Effect of video clip education on occupational exposure of obstetrical interns was comprehensively assessed.Results The awareness rate of all occupational exposure knowledge were 100.00%in the observation group，which were significantly higher than 0.00%～54.17%in the control group　（P＜0.05）.The implementation rate of self-protection against occupational exposure were 43.75%～87.50%in the observation group，which were significantly higher than 6.25%～52.08%in the control group　（P＜0.01）；Interns in the observation group showed higher self-protection against high-risk occupational exposure，while those in the control group showed lower self-protection against all levels of occupational exposure，and the difference was significant（P＜0.05）.The incidence rates of scratching or stabbing，incidence rate of pollution by blood and body fluid in the observation group were significantly higher than those in the control group（P＜0.05）.Conclusion Video clip education can enhance the awareness degree of occupational exposure among interns，promote self-protection measures against occupational exposure，and reduce the incidence of occupational exposure，it is worthy to be promoted. 2016 Vol. 23 (15): 172-175 [Abstract] ( 92 ) HTML (38 KB)  PDF  (0 KB)  ( 36 ) 176 The effect of early rehabilitation nursing on neurological function and quality of life of Patients with craniocerebral injury ZUO Xing-mei;OU Jie-song;CHEN Qiu-min Objective To explore the effect of early rehabilitation nursing on neurological function and quality of life of patients with craniocerebral injury.Methods A total of 89 patients with craniocerebral injury admitted to our hospital from September 2013 to September 2015 were randomly divided into the control group and the observation group.The control group was given routine nursing，and the observation group was given early rehabilitation nursing.The nerve function before and after nursing and quality of life were compared between two groups.Results Before nursing，there was no significant difference between the two groups of patients with NIHSS score and Fugl-Meyer score（P＞0.05）.After nursing，the observation group NIHSS score was significantly lower than that of control group，Fugl-Meyer score was significantly higher than that of control group（P＜0.05.）The quality of life of QOL-100 score in the observation group in the physiological field，psychological field，independent field and social field scores were higher than that of control group（P＜0.05）.Conclusion Early rehabilitation nursing can effectively improve the nerve and motor function in patients with craniocerebral injury，which can improve the quality of life，and is worthy of clinical popularization and application. 2016 Vol. 23 (15): 176-178 [Abstract] ( 116 ) HTML (39 KB)  PDF  (0 KB)  ( 3 ) 179 Influence of labor in liberal Position on delivery outcome in PrimiPara XU Xia-ying;FU Chun;CHEN Xing-mei Objective To explore the influence of labor in liberal position on delivery outcome in primipara.Methods From January 2014 to December 2015，3125 primiparae admitted into our obstetrical department were selected as research objects.There were 1634 primiparae delivered in 2015 were selected as observation group.The rest were chosen as control group.In the observation group，labor in liberal positon during nursing was provided，while in the control group，labor in traditional position during nursing was used.The delivery mode and complications of mother and infant were compared in the two groups.Results In the observation group，spontaneous delivery rate was increased，and rates of caesarean section，cervical laceration，and lateral episiotomy were decreased with statistical differences（P＜0.05）.Conclusion Labor in liberal positon is beneficial to correct occipitotransverse position and occipitoposterior position into occiput anterior position and shorten stages of labor，and is beneficial for delivery outcome in primipara and alleviation of genital tract injury.The clinical effect is remarkable and is worthy of promotion. 2016 Vol. 23 (15): 179-181 [Abstract] ( 97 ) HTML (36 KB)  PDF  (0 KB)  ( 26 ) 182 Effect of early nursing intervention on negative emotions and the incidence rate of comPlications in Patients treated with hemodialysis YAN Jing;ZHU Wen-jiang;BAO Min-rui;CHEN Wen-xuan;LIU Yan Objective To explore the effect of early nursing intervention on negative emotions and the incidence rate of complications in patients treated with hemodialysis.Methods 100 cases of patients with chronic renal failure who were treated with hemodialysis in our hospital from November 2014 to December 2015 were selected and divided into control group and observation group according to their admission time，50 cases in each group.Patients in the control group were implemented routine nursing，who in the observation group were given early nursing intervention based on the control group.The nursing satisfaction，negative emotions and complications after nursing were compared between the two groups after nursing.Results The scores of SAS and SDS in the observation after nursing were better than those of control group（P＜0.05）.The incidence rate of complications in the observation group was lower than that of control group（P＜0.05）.The nursing satisfaction in the observation group was obviously better than that of control group，with a significant difference（P＜0.05）.Conclusion The implementation of early nursing intervention in patients treated with hemodialysis has significant effect，which can ease the patients with negative emotions and decrease the rate of concurrent，and it is worthy of popularization and application. 2016 Vol. 23 (15): 182-184 [Abstract] ( 118 ) HTML (40 KB)  PDF  (0 KB)  ( 26 ) 185 ImPact of Predictive nursing measures on PerioPerative Period glycemic control of Patients with diabetic cataract FANG Miao-juan Objective To explore the impact of predictive nursing measures on perioperative period glycemic control of patients with diabetic cataract.Methods 120 patients with diabetic cataract were random divided into observation group（n=60）and control group（n=60）.All patients were given extracapsular cataract extraction combined with intraocular lens implantation.Patients in control group were given routine nursing，and patients in observation group were given predictive nursing.The blood glucose level，vision recovery and incidence rate of postoperative complications in two groups were compared.Results The FPG and 2 h PG at one day before operation had no statistical significance between two groups（P＞0.05），which were obvious lower than that of control group at 7 days after operation　（P＜0.05）.The postoperative vision recovery excellence rate in observation group was 95.0%，obvious higher than that was 81.6%in control group　（P＜0.05）；The incidence rate of complications in observation group was 8.3%，obvious lower than that was 30.0%in control group（P＜0.01）.Conclusion Perioperative period predictive nursing can control the blood glucose level of patients with diabetic cataract effectively，decrease postoperative complications and improve treatment effects. 2016 Vol. 23 (15): 185-187 [Abstract] ( 131 ) HTML (40 KB)  PDF  (0 KB)  ( 28 ) 188 ImPact of non drug nursing measures on PostoPerative Pain of school aged children with acute aPPendicitis GUO Li-ping;XIE Li-juan Objective To elpore the clinical effects of non drug nursing measures nursing intervention on the treatment of school aged children with acute appendicitis.Methods 88 school aged children with acute appendicitis of our hospital from November 2013 to November 2015 were selected and were randomly divided into control group and observation group，each group was 44 cases.Child patients in control group were given routine appendicitis operation nursing mode and child patients in observation group were given non drug nursing measures.The time of off-bed，the total hospital stays，improvement in VAS pain scores at day 3 and day after surgery，adverse reactions in the perioperative period of appendicitis and parents'satisfaction with nursing service in the treatment of acute appendicitis operation after appendicitis operation between two groups were compared.Results The postoperative time of off-bed and total hospital stays in observation group were obvious shorter than that of control group，and the difference was statistically significant（P＜0.05）；The improvement in VAS pain scores at day 3 and day after surgery was obvious bigger than that of control group，and the difference was statistically significant（P＜0.05）；The adverse reactions in the perioperative period of appendicitis was obvious less than that of control group，and the difference was statistically significant（P＜0.05）；The parents′satisfaction with nursing service in the treatment of acute appendicitis operation was obvious higher than that of control group，and the difference was statistically significant（P＜0.05）.Conclusion The clinical effect of using non drug nursing measures nursing intervention on the treatment of school aged children with acute appendicitis is very obvious，and it is worthy of aplication. 2016 Vol. 23 (15): 188-190 [Abstract] ( 112 ) HTML (36 KB)  PDF  (0 KB)  ( 30 ) 191 Study on the causes and nursing methods of metabolic syndromes among community residents in Shenzhen SUN Xiao-ling;SUN Shi-hua;LUO Xia Objective To investigate the risk factors of metabolic syndromes（MS）in community residents in Shenzhen，and to explore the nursing methods accordingly.Methods With adoption of the sampling method，2000 residents in Futian community over the age of 30 from March 2014 to June 2015 were involved as the research object and divided into Healthy Group and MS Group according to the Metabolic Syndrome Diagnostic Criteria.Then，the single factor and multi-factor were utilized to analyze the general factors of patients and explore the pathogenes is factors of MS.Based on the risk factors，relevant nursing measures were discussed.Results Among 2000 samples involved in this study，386 patients were diagnosed as MS，and the incidence rate was 19.30%.The single-factor analysis result showed that male with increasing ages，low educational background，high labor intensity，high psychological pressure，bad living habits and related genetic genes had higher incidence of MS　（P＜0.05）.Gender，age，educational background，labor intensity，psychological stress，living habits and genetic were the risk factors of MS for Shenzhen residents.Conclusion The risk factors of MS for Shenzhen residents include gender，age，educational background，labor intensity，psychological stress，living habits and genetic.Targeted nursing measures play a key role in reduction of morbidity and improvement of the preventive effect. 2016 Vol. 23 (15): 191-193 [Abstract] ( 119 ) HTML (33 KB)  PDF  (0 KB)  ( 36 ) 194 The nursing and clinical effect for acute alcohol intoxication caused rhabdomyolysis CAO Yu-ping Objective To investigate the nursing and clinical effect for acute alcohol intoxication caused rhabdomyolysis.Methods 80 cases with acute alcohol intoxication caused rhabdomyolysis from January 2011 to June 2015 in our hospital were randomly divided into two group，40 cases in each group，the observation group were used the interventions in this study nursing，the control group were implemented routine care，then complications occurred during treatment intervention HAMD and HAMA scores after treatment，and bed time and hospital stay were compared in the two groups. Results The acute renal failure，pulmonary edema and cardiac arrest ratio in the observation group were lower than that of control group　（P＜0.05），after the intervention，the HAMD and HAMA scores in observation group were significantly lower than that of control group　（P＜0.05），getting out of bed time in observation group was shorter than that of control group　（P＜0.05），the total length of stay in observation group was shorter than that of control group　（P＜0.05）.Conclusions Effective nursing intervention can significantly reduce complications during treatment and improve patient mental anxiety and depression，so it can prompte the patients′soon recovered. 2016 Vol. 23 (15): 194-197 [Abstract] ( 107 ) HTML (45 KB)  PDF  (0 KB)  ( 21 )

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