降钙素原、超敏C-反应蛋白在新生儿败血症早期诊断中的应用价值

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Abstract Objective To explore the value of procalcitonin（PCT）and high-sensitivity C-reactive protein（hs-CRP）in early diagnosis of neonatal septicemia.Methods From August 2014 to February 2016，200 neonates with sepsis admitted into our hospital were selected as research group，and another group of 200 neonates with non-infectious diseases during the same period was chosen as control group.The blood culture was regarded as golden standard.The blood culture，PCT and hs-CRP from serum in all participants were tested and outcomes were statistically analyzed.Results In the research group，proportion of positive PCT among 200 neonates was highest，and blood culture was in the second.The positive rate of hs-CRP was lowest.In the research group，the level and positive rate of serum PCT were both higher than those in the control group　（P＜0.05）.The level of hs-CRP in the research group was higher than that in the control group　（P＜0.05），but no statistical difference was displayed after comparing the positive rate of hs-CRP in both groups （P＞0.05）.Setting serum PCT≥0.5 ng/ml and hs-CRP≥8 mg/L as positive standard，the sensitivity，specificity，and accuracy of serum PCT on diagnosing neonatal septicemia were all higher than those by testing on hs-CRP（P＜0.05）.Conclusion Both PCT and hs-CRP have guiding significance on clinical diagnosis and treatment of neonatal septicemia，especially PCT can be considered as an important diagnostic and monitoring index on neonatal septicemia，which can play a vital clinical value on early diagnosis and treatment of neonatal sepsis.

Key words： Procalcitonin High-sensitivity C-reactive protein Blood culture Septicemia

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	HUANG Chang-e
	LIU Yun-hua
	WANG Jia

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HUANG Chang-e,LIU Yun-hua,WANG Jia. Early diagnosis value of Procalcitonin and high-sensitivity C-reactive Protein in neonatal sePticemia[J]. 中国当代医药, 2016, 23(15): 130-132.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I15/130

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