CK5/6、p63、CD10在乳腺良恶性病变中的表达及意义

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Abstract Objective To study the expression and significance of CK5/6，p63 and CD10 in breast benign and malignant lesions.Methods 242 patients with breast proliferative lesions in our hospital from January 2010 to December 2015 were selected，among whom 151 patients had UDH　（UDH group），54 patients ADH　（ADH group）and 37 patients DCIS （DCIS group）；26 patients had microinvasion　（DCIS accompanied with microinvasion group）；83 patients had non-special invasive cancer（non-special invasive cancer group）.Immunohistochemical Envison two-step method was applied to test the expression of CK5/6，p63 and CD10 in the specimen in each group.Results The expression of CK5/6 in UDH group was significantly higher than that in ADH group，DCIS group，DCIS accompanied with microinvasion group and non-special invasive cancer group，the differences were statistically significant（P＜0.05）；The expression differences of CK5/6 among ADH group and DCIS group，DCIS accompanied with microinvasion group，non-special invasive cancer group were statistically significant　（P＜0.05）.Successive positive expressions of p63 and CD10 in basement membrane in UDH group，ADH group and DCIS group were not different，they were not expressed in DCIS accompanied with microinvasion group and non-special invasive cancer group，there were statistical differences among UDH group，ADH group，DCIS group and DCIS accompanied with microinvasion group，non-special invasive cancer group（P＜0.05）.Conclusion The combined test of the three indicators of CK5/6，p63 and CD10 is favorable in identifying breast benign and malignant lesions.

Key words： Breast lesions Immunohistochemistry Differential diagnosis

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河南省濮阳市科技计划项目（160640）

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	ZHU Zheng-yan

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ZHU Zheng-yan. ExPression and significance of CK5/6，P63 and CD10 in breast benign and malignant lesions[J]. 中国当代医药, 2016, 23(15): 109-111.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2016/V23/I15/109

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