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2020 Vol. 27, No. 29
Published: 2020-10-18
 
 
4 Clinical effect of Pancreatic Kininogenase Combined with Pregabalin in the treatment of painful diabetic peripheral neuropathy
CAO Chun-li1 ZHANG Jing1 WU Shu-qiong1▲ XIONG Fu2
Objective To evaluate the effect and safety of Pancreatic Kininogenase combined with Pregabalin in the treatment of painful diabetic peripheral neuropathy (PDPN). Methods From January to December 2017, 68 patients with PDPN treated in the Endocrinology Department of Hubei Provincial Hospital of Integrated Chinese and Western Medicine were selected as the research subjects, and they were divided into the control group and the treatment group by the random number table method, with 34 cases in each group. The patients in the two groups were given basic medical treatment such as blood glucose control. On the basis of this, the control group was treated with Pregabalin and the treatment group was treated with Pancreatic Kininogenase and Pregabalin for 8 weeks. Visual analogue scale (VAS)was used to evaluate the pain intensity changes between the two groups before and after treatment. Sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) were measured and compared between the two groups. The incidence of adverse drug reactions was recorded. Results There was no statistically significant difference in the VAS score between the two groups before treatment (P＞0.05). After treatment, the VAS scores in the two groups were lower than those in the same group before treatment, the differences were statistically significant (P＜0.05), and the VAS score in the treatment group after treatment was lower than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in the SNCV before treatment between the two groups (P＞0.05). The SNCV after treatment in the two groups was higher than that in the same group before treatment, and the difference was statistically significant (P＜0.05). And the SNCV after treatment in the treatment group was higher than that in the control group, the difference was statistically significant (P＜0.05). There was no significant difference in MNCV before treatment between the two groups (P＞0.05). The MNCV after treatment in the treatment group was higher than that in the same group before treatment, and the difference was statistically significant (P＜0.05). There was no significant difference in MNCV between the control group before and after treatment (P＞0.05). The MNCV after treatment in the treatment group was higher than that in the control group, with statistically significant difference (P＜0.05). There was no significant difference in the total incidence rate of adverse reactions between the two groups (P＞0.05). Conclusion Pancreatic Kininogenase combined with Pregabalin has a better effect on pain improvement than Pregabalin alone in the treatment of PDPN. At the same time, it can improve the SNCV and MNCV of patients. The effect is better than that of Pregabalin alone, and it is safe for clinical application.
2020 Vol. 27 (29): 4-7 [Abstract] ( 37 ) HTML (40 KB)  PDF  (0 KB)  ( 10 )
8 Clinical effect of acupoint application of Zhiou Prescription combined with Tropisetron in the treatment of patients with nausea and vomiting after chemotherapy
WANG Shuang-shuang1 XU Xiao-wan2▲ QING Zhao-qian1 ZHENG Guo-yin2
Objective To explore the clinical effect of acupoint application of Zhiou Prescription combined with Tropisetron in the treatment of patients with nausea and vomiting after chemotherapy. Methods A total of 48 patients who underwent XELOX chemotherapy in the Department of Oncology of Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital) from August 2017 to May 2019 were selected as subjects. By the random number table method, patients were divided into the treatment group and the control group, 24 cases in each group. All patients were treated with conventional treatment. In the control group, Tropisetron on the basis of conventional treatment was added, and in the treatment group, acupoint application of Zhiou Prescription on the basis of the control group was added. The clinical efficacy, improvement in nausea and vomiting, degree of gastrointestinal reaction, quality of life and safety in the two groups were observed. Results After treatment, the total clinical effective rate in the treatment group(91.67%) was higher than that in the control group (70.83%), and the difference was statistically significant (P＜0.05).Before treatment, there were no statistically significant differences in the scores of nausea and vomiting and QLQ-C30 on the quality of life measurement scale between the two groups (P＞0.05). After treatment, the nausea and vomiting scores of the two groups were lower than those before treatment, and the nausea and vomiting scores in the treatment group were lower than those in the control group, the differences were statistically significant (P＜0.05). After treatment,the QLQ-C30 scores of the two groups were higher than those before treatment, and the QLQ-C30 score of the treatment group was higher than that of the control group, the differences were statistically significant (P＜0.05). After treatment, the total effective rate of the gastrointestinal reaction (87.50%) in the treatment group was higher than that in the control group (62.50%), and the difference was statistically significant (P＜0.05). The total incidence of adverse reactions was 8.33% in the treatment group, which was not significantly different from that in the control group accounting for 16.67% (P＞0.05). Conclusion Acupoint application of Zhiou Prescription combined with Tropisetron can effectively relieve the nausea and vomiting of patients after XELOX chemotherapy, improve their quality of life, and obtain a remarkable clinical effect with high safety, which provides a scientific basis for further promotion and application.
2020 Vol. 27 (29): 8-11 [Abstract] ( 34 ) HTML (43 KB)  PDF  (0 KB)  ( 12 )
12 Effect of intravitreal injection of Ranibizumab combined with retinal photocoagulation in the treatment of diabetic macular edema
ZHANG Dan WANG Jiao-jiao
Objective To explore the effect of intravitreal injection of Ranibizumab combined with retinal photocoagulation in the treatment of diabetic macular edema. Methods A retrospective analysis was conducted on the clinical data of 90 patients (91 eyes) with diabetic macular edema diagnosed in our hospital from January 2017 to January 2018. According to different treatment methods, they were divided into the treatment group (45 cases, 46 eyes) and the control group (45 cases, 45 eyes). The patients in the treatment group were given intravitreal injection of Ranibizumab combined with macular grid photocoagulation or focal photocoagulation, and the patients in the control group were given Ranibizumab single treatment. The best corrected visual acuity at 1 month and 3 months after treatment, the retinal thickness at macula central fovea before and after treatment, the macular edema and leakage, and the occurrence of adverse reactions were compared. Results The best corrected visual acuity at 3 months after treatment in the treatment group was better than that in the control group, with statistically significant difference (P＜0.05). There was no statistically significant difference in the best corrected visual acuity at 1 month after treatment between the two groups (P＞0.05). The retinal thickness at macula central fovea in the two groups at 1 month and 3 months after treatment was lower than that before treatment, with statistically significant difference (P＜0.05). The retinal thickness at macula central fovea in the treatment group at 1 month and 3 months after treatment was lower than that in the control group, with statistically significant difference (P＜0.05). The retinal thickness at macula central fovea in the control group at 3 months after treatment was higher than that in the control group at 1 month after treatment, with statistically significant difference (P＜0.05). The fundus fluorescein angiography was repeated at 3 months after treatment, and the proportion of leakage eyes in the treatment was lower than that in the control group, with statistically significant difference (P＜0.05). During the treatment follow-up, there were no adverse reactions in eyes or whole body in the two groups. Conclusion In comparison with intravitreal injection of Ranibizumab single treatment, intravitreal injection of Ranibizumab combined with retinal photocoagulation has better effect in improving visual acuity and restoring retinal function in patients with diabetic macular edema, with better safety.
2020 Vol. 27 (29): 12-16 [Abstract] ( 31 ) HTML (41 KB)  PDF  (0 KB)  ( 8 )
17 Clinical study of Lichtenstein operation using light polypropylene plain film in the practice of the elderly with rapid rehabilitation hernia surgery
FAN Zhong-bao1 SHEN Jian-fen2▲ WANG Jian3 YU Hao4 LIU Yan-feng5
Objective To explore the superiority and feasibility of Lichtenstein operation using light polypropylene plain film in the practice of the elderly with rapid rehabilitation hernia surgery. Methods From January 2015 to January 2019, 120 elderly patients with inguinal hernia who were admitted to the First Department of General Surgery of People′s Hospital of China Medical University, People′s Hospital of Liaoning Province were selected as the research subjects. They were divided into the study group (n=67) and the control group (n=53) according to different meshes and surgical methods. In the study group, light polypropylene plain film for Lichtenstein was used, and in the control group,polypropylene-pro-lene hernia system (PHS) patch for open preperitoneal space tension-free hernia repair was applied.The operation-related indicators, postoperative pain score, postoperative complications, quality of life score and total satisfaction at one month after operation, and recurrence at one year of follow-up were analyzed and compared. Results The operation time, bed-off activity time, and hospital stay of the study group were shorter than those of the control group, the incidence of postoperative pain above moderate and foreign body sensation was lower than that of the control group, with statistically significant differences(P ＜0.05). The pain scores at the first, third, fifth, and seventh days after surgery in the study group were lower than those in the control group, with statistically significant differences (P＜0.05). The quality of life score and total satisfaction at one month after surgery in the study group were higher than those in the control group, with statistically significant differences (P＜0.05). There were no complications such as incision infection, urinary retention, seroma, etc., and there was no recurrence after one year of follow-up.Conclusion The use of light polypropylene plain film for Lichtenstein operation is simple, has few complications, and has high postoperative rehabilitation quality. It has obvious clinical advantages in the practice of rapid rehabilitation hernia surgery in the elderly.
2020 Vol. 27 (29): 17-20 [Abstract] ( 32 ) HTML (41 KB)  PDF  (0 KB)  ( 12 )
21 Research advances on the role of ubiquitin-proteasome pathway in the pathogenesis of epilepsy
ZHANG He-bo LIU Xiao-liang ZHAO Yan-yan▲
Epilepsy is a common chronic nervous system disease, which is characterized by sudden, recurrent seizures and temporary central nervous system dysfunction caused by excessive discharge of brain neurons. Recent studies have shown that the occurrence of epilepsy is closely related to ion channels, neurotransmitters and synaptic connections. Ubiquitin-proteasome pathway is an important protein degradation pathway in vivo, which regulates many cellular physiological processes. Many substrates modified by ubiquitination are ion channel that affect central nervous excitability,such as voltage-gated ion channels including sodium channels and potassium channels as well as ligand-gated ion channels including AMPA receptor and NMDA receptor. Ubiquitination affects neuronal excitability by regulating the expression level of these channel proteins, which is closely related to the pathogenesis of epilepsy.
2020 Vol. 27 (29): 21-24 [Abstract] ( 31 ) HTML (35 KB)  PDF  (0 KB)  ( 12 )
25 Research progress on the diagnostic value of serum HCG, E2, and P levels in early pregnancy in embryo abortion
2, and P levels in early pregnancy in embryo abortion[J]. 中国当代医药, 2020,27(29): 25-28')" href="#"> LIU Hai-yan1 LI Yu-ling2▲
With the increasing incidence of embryo abortion, how to predict and intervene in advance to reduce the incidence has become one of the urgent problems in obstetrics and gynecology. At present, it is found that the factors of embryo abortion are complex and various, among which the correlation with endocrinology is still a research hotspot.Clinical early pregnancy outcome prediction of the common indicators include serum human chorionic gonadotropin(HCG), estradiol (E2), progesterone (P) and other hormones, for pregnant women with a history of embryo failure, whose levels are often different from those of normal pregnant women. The author has read a great deal of literature and found that pregnant women have some patterns in different gestational weeks: At the fourth week of pregnancy, the levels of P and E2 have an optimal threshold value; HCG increases most rapidly before the sixth week of pregnancy. At the seventh week of pregnancy, both P and E2 belong to the luteal-placental transition period, which is the transition period to the peak period. The peak reaches 8-10 weeks of pregnancy, the P20 value at the seventh week of gestation is the lower limit of the reference value, which is the key to the success of pregnancy. The pregnant women with a history of abortive embryos should strengthen the P monitoring and early intervention in the follicular and luteal stages before pregnancy, which is conductive to the development of the embryo outcomes. Therefore, monitoring the level of serum P,E2 and HCG in different gestational weeks to explore the correlation between the level and the outcome of pregnancy can reflect the development of embryos to a certain extent, and provide scientific theoretical basis for clinical early pregnancy intervention.
2020 Vol. 27 (29): 25-28 [Abstract] ( 32 ) HTML (41 KB)  PDF  (0 KB)  ( 12 )
29 Clinical effect of Tongxinluo Capsules combined with Sacubitril and Valsartan in the treatment of pulmonary hypertension due to left heart disease
TANG Zeng-yao MEI Han-ying LIU Ji-wen WANG Xin-wang ZHU Bao-cheng LIU Yu-lian
Objective To observe the clinical effect of Tongxinluo Capsules combined with Sacubitril and Valsartan in the treatment of pulmonary hypertension due to left heart disease (PH-LHD). Methods A total of 108 patients with PH-LHD who admitted in our hospital from August to December 2019 were selected and randomly divided into the control group, the observation group A and the observation group B, with 36 cases in each group. Three groups were given routine treatment, the control group was given Valsartan based on routine treatment, the observation group A was given Sacubitril and Valsartan based on routine treatment, and the observation group B was treated with Sacubitril and Valsartan combined with Tongxinluo Capsules based on routine treatment. After treatment for 3 months, the clinical efficacy, arterial partial pressure of oxygen (PaO2), pulmonary arterial pressure (pulmonary arterial systolic pressure[PASP], pulmonary arterial diastolic pressure [PADP]) were compared among the three groups. Results The effective rate of the observation group B were higher than those of the observation group A and the control group, the differences were statistically significant (P＜0.05). The level of PaO2 in the three groups after treatment were higher than those before treatment, the differences were statistically significant (P＜0.05). The level of PaO2 in the observation group B was higher than that in the observation group A and the control group, the differences were statistically significant (P＜0.05).After treatment, the level of PASP and PADP of the three groups were lower than those before treatment, the differences were statistically significant (P＜0.05). The levels of PASP and PADP in the observation group B were lower than those in the observation group A and the control group, the differences were statistically significant (P＜0.05). Conclusion Tongxinluo capsule combined with Sacubitril and Valsartan in the treatment of PH-LHD can increase clinical efficacy, and improve PaO2 and pulmonary arterial pressure, which is worthy of clinical promotion and application.
2020 Vol. 27 (29): 29-31 [Abstract] ( 31 ) HTML (36 KB)  PDF  (0 KB)  ( 11 )
32 Clinical effect of Tripterygium Glycosides in the treatment of connective tissue disease related interstitial lung disease
CHEN Hu GAN Feng-ying JU Yan-juan GU Xiao-jing LI Rong-ping WANG Biao GUO Di-bin▲
 Objective To investigate the clinical efficacy of Tripterygium Glycosides in the treatment of connective tissue disease related interstitial lung disease (CTD-ILD). Methods A total of 40 patients with CTD-ILD admitted to our hospital from April to October 2019 were selected and randomly divided into the control group and the experiment group, with 20 cases in each group. The control group was treated with Glucocorticoids, and the experiment group was given Tripterygium Glycosides treatment on the basis of the control group. The clinical treatment efficiency, improvement of lung function, incidence of adverse reactions were compared between the two groups. Results The total effective rate of treatment in the experiment group was 80.00%, which was higher than 65.00% in the control group, the difference was statistically significant (P＜0.05). Before treatment, there were no significant difference in the levels of total lung volume (TLC), CO diffusion (DLCO), and arterial oxygen partial pressure (PaO2) between the two groups (P＞0.05). After treatment, the levels of TLC, DLCO, and PaO2 were higher than those before treatment in the two groups,and the levels of TLC, DLCO, and PaO2 in the experiment group were higher than those in the control group (P＜0.05).The total incidence of drug side effect in the experiment group was lower than that in the control group (P＜0.05). Conclusion Tripterygium Glycosides has a significant clinical effect on CTD-ILD, which can significantly improve the patient′s lung function, and has low incidence of adverse reactions. It may become one of the options in the treatment of CTD-ILD.
2020 Vol. 27 (29): 32-34 [Abstract] ( 22 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
35 Influonce of Thalidomide in the treatment of rheumatoid arthritis and the influence on the balance of differentiation of Th17 and Treg cells
WU Xiao-liang1 SU Wei-xiong2
Objective To observe the influence of Thalidomide on the differentiation balance of Th17 cells and Treg cells in rheumatoid arthritis (RA) patients. Methods A total of 80 RA patients admitted to our hospital from June 2018 to October 2019 were selected as research objects, according to the method of random number table, the selected patients were divided into the treatment group and the control group, 40 cases in each group. Meanwhile, 40 healthy people who had physical examination in our hospital in the same period were selected as the healthy group. The patients in the control group were given routine treatment, while the patients in the treatment group were given Thalidomide on the basis of the control group. The clinical effects of the two groups were compared, the ratio of Th17 cells, Treg cells and Th17/Treg cells were observed before and after treatment of the two groups. Results The total effective rate of the treatment group was 95.00%, which was higher than 75.00% of the control group, the difference was statistically significant(P＜0.05). The ratio of Th17 cells and Th17/Treg cells in the treatment group and the control group before treatment were higher than those in the healthy group, and the ratio of Treg cell subsets in the treatment group and the control group before treatment were lower than those in the healthy group, the differences were statistically significant (P＜0.05).The ratio of Th17 cells and Th17/Treg cells in the treatment group and the control group before treatment were higher than those in the healthy group, and the ratio of Treg cell subsets in the treatment group and the control group after treatment were lower than those in the healthy group, the differences were statistically significant (P＜0.05). There were no significant differences in Th17, Treg cell proportion and Th17/Treg between the treatment group and the control group before treatment (P＞0.05). The ratio of Th17 cells and Th17/Treg cells after treatment in the two groups of patients were lower than those before treatment, and the ratio of Treg cell subsets after treatment in the two groups of patients were higher than those before treatment, the differences were statistically significant (P＜0.05). The ratio of Th17 cells and Th17/Treg cells in the treatment group after treatment were lower than those in the control group, and the ratio of Treg cell subsets in the treatment group after treatment was higher than that in the control group,the differences were statistically significant (P＜0.05). Conclusion Thalidomide can regulate the balance of Th17 and Treg cells, which is an important supplement to the balance mechanism of Treg and Th17 cell subsets, and can provide a potential new way in the treatment of RA and other autoimmune diseases.
2020 Vol. 27 (29): 35-38 [Abstract] ( 28 ) HTML (36 KB)  PDF  (0 KB)  ( 12 )
39 Clinical effect comparison of polyvinyl alcohol foam embolization microparticles and polyvinyl alcohol embolization microspheres in interventional embolization therapy for patients with massive hemoptysis
TIAN Yun-fei ZOU Song LIN Ying ZHOU Tong-gang ZHANG Meng-long
Objective To compare the clinical effecy of polyvinyl alcohol foam embolization microparticles and polyvinyl alcohol embolization microspheres in interventional embolization therapy for patients with massive hemoptysis. Methods A total of 86 patients with massive hemoptysis in our hospital who failed in the conservative treatment of internal medicine and needed to be treated by interventional embolization from August 2017 to February 2019 were selected as the research objects and divided into the study group and the control group by random number table method, with 43 cases in each group. The study group used polyvinyl alcohol embolization microspheres for interventional embolization, and the control group used polyvinyl alcohol foam embolization particles for interventional embolization. The short-term, midterm and long-term effect and complications of the two groups after surgery were compared. Results There were no significant differences in the total effective rate at 7 d after surgery, the success rate of hemoptysis control, and the incidence of complications at 1 and 12 months after surgery (P>0.05). Conclusion Compared with polyvinyl alcohol foam embolization microparticles, polyvinyl alcohol embolization microspheres have the same clinical effect and high safety in interventional embolization for massive hemoptysis, which is worthy of clinical promotion and application.
2020 Vol. 27 (29): 39-41 [Abstract] ( 33 ) HTML (34 KB)  PDF  (0 KB)  ( 17 )
42 Therapeutical effect obeservation of Pulmicort Respules combined with Terbutaline in bronchiectasis
ZHANG Zu-hua1 LI Ming2
Objective To observe the therapeutical effect of Budesonide Suspension for Inhalation (Pulmicort Respules)combined with Terbutaline in bronchiectasis. Methods A total of 60 patients with bronchiectasis who were admitted to People′s Hospital of Pingxiang City from February 2016 to October 2019 were selected as the research objects and divided into the control group and the observation group by random number table method, with 30 cases in each group.The control group was treated with routine medicine, and the observation group was treated with Pulmicort Respules combined with Terbutaline. The clinical efficacy, scores of clinical symptoms (cough, sputum volume, viscous sputum),the levels of inflammatory markers (C-reactive protein [CRP], procalcitonin [PCT], fibrinogen) and length of hospital stay were compared between the two groups after 7 d of treatment. Results The total effective rate of the observation group (93.33%) was higher than that of the control group (73.33%), and the difference was statistically significant (P＜0.05). The scores of cough, sputum volume and viscous sputum of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The levels of CRP, PCT and fibrinogen in the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05).The length of hospital stay of the observation group was shorter than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The effect of Pulmicort Respules combined with Terbutaline in treatment of patients with bronchiectasis was significant, it can improve the clinical symptoms, eliminate the inflammation, and shorten the length of hospital stay.
2020 Vol. 27 (29): 42-44 [Abstract] ( 27 ) HTML (35 KB)  PDF  (0 KB)  ( 10 )
45 Clinical effect of Meilu Xiaocuo Ointment combined with ozone water wet compress in the treatment of children with eczema
ZHANG Wen-qiang
Objective To investigate the clinical effect of Meilu Xiaocuo Ointment combined with ozone water wet compression in the treatment of children with eczema. Methods A total of 76 children with eczema admitted to our hospital from January to December 2019 were selected as the research objects and divided into the control group and the treatment group by random number table method, with 38 cases in each group. The control group was treated with ozone water wet compress, and the treatment group was treated with Meilu Xiaocuo Ointment combined with ozone water wet compress. The improvement of clinical symptoms before and after treatment was compared in the treatment group, the total effective rate and the levels of serum interleukin-2 (IL-2), interleukin-4 (IL-4) and interferon-γ (IFN-γ) of the two groups before and after treatment were compared. Results After treatment, the elimination rates of multiple clinical symptoms in the treatment group were higher than 80.00%. The total clinical effective rate of the treatment group(92.11%) was higher than that of the control group (78.95%), and the difference was statistically significant (P＜0.05).After treatment, the levels of serum IL-2 and IFN-γ in the two groups were lower than those before treatment, while the level of IL-4 was higher than that before treatment, and the differences were statistically significant (P＜0.05). The level of serum IL-2 in the treatment group was lower than that in the control group, and the difference was statistically significant (P＜0.05). There were no statistically significant differences in IFN-γ and IL-4 levels between the two groups (P＞0.05). Conclusion Meilu Xiaocuo Ointment combined with ozone water wet compress is effective in the treatment of children with eczema, and it is worthy of clinical promotion and application.
2020 Vol. 27 (29): 45-48 [Abstract] ( 27 ) HTML (37 KB)  PDF  (0 KB)  ( 15 )
49 Clinical date analysis of 24 patients with Hailey-Hailey disease
SHAO Li-fang LI Yuan-yuan▲
Objective To investigate the clinical characteristics, inducing factors and treatment of Hailey-Hailey disease (HHD). Methods Clinical data of 24 patients with HHD admitted to department of dermatology in our hospital from January 1999 to December 2018 were retrospectively analyzed. Results Among the 24 patients, the male/female ratio was 3.8∶1. Patients age ranged from 31 to 70 years old, mean age was (49.54±9.02) years old. The onset age ranged from 13 to 47 years old, mean onset age was (31.04±9.49) years old. Groins and armpits were the most involved locations of rash. Hot and humid climate in summer was the most common triggers of HHD and followed by drinking,spicy foods and friction. The therapy of Compound Glycyrrhizin Injection, Minocycline Capsules, Glucosidorum Tripterygll Totorum combined with local symptomatic treatment was effective to HHD. Conclusion HHD is long-lasting, difficult to cure andprone to recurrence. Traditional treatment with systemic and topical medications can control symptoms, but it is difficult to prevent recurrence. Surgical treatment, laser treatment, and botulinum toxin injection play a certain role in preventing recurrence.
2020 Vol. 27 (29): 49-52 [Abstract] ( 30 ) HTML (38 KB)  PDF  (0 KB)  ( 13 )
53 Clinical effect of Entecavir combined with Silybin in the treatment of chronic hepatitis B with non-alcoholic fatty liver disease
CHEN Man ZHANG Hong-li
Objective To observe the clinical effect of Entecavir combined with Silybin in the treatment of chronic hepatitis B with non-alcoholic fatty liver disease. Methods A total of 120 patients with chronic hepatitis B and non-alcoholic fatty liver disease who treated in our hospital from January 2018 to September 2019 were selected as the research subjects and divided into the control group and the experimental group by random number table method, with 60 cases in each group. The control group was treated with Entecavir, and the experimental group was treated with Entecavir combined with Silybin. The liver function indexes (alanine aminotransferase [ALT], aspartate aminotransferase[AST], hepatitis B virus DNA [HBV-DNA]), the blood lipid indexs (total cholesterol [TC], triacylglycerol [TG], high density lipoprotein cholesterol [HDL-C], low density lipoprotein cholesterol [LDL-C]), abdominal B-ultrasound grading before and after treatment, clinical efficacy and adverse reactions of the two groups were compared. Results There were no statistically significant differences in the levels of ALT, AST and HBV-DNA between the two groups before treatment (P＞0.05). After treatment, the levels of ALT, AST and HBV-DNA in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in the levels of TC, TG, HDL-C and LDL-C between the two groups before treatment (P＞0.05). After treatment, the levels of TC, TG and LDL-C in the experimental group were lower than those in the control group, the level of HDL-C was higher than that in the control group, and the differences were statistically significant (P＜0.05).There was no statistically significant difference between the two groups in the abdominal B-ultrasound grading before treatment (P＞0.05). After treatment, the abdominal B-ultrasound grading in the experimental group was better than that in the control group, and the difference was statistically significant (P＜0.05). The total effective rate of the experimental group was higher than that of the control group, the total incidence of adverse reactions was lower than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion The effect of Entecavir combined with Silybin in the treatment of patients with chronic hepatitis B and non-alcoholic fatty liver disease is more accurate. It can significantly improve the liver function indexs and blood lipid indexs of patients, improve the total effective rate of treatment, reduce the total incidence of adverse reactions, and it is worthy of clinical promotion and application.
2020 Vol. 27 (29): 53-56 [Abstract] ( 28 ) HTML (36 KB)  PDF  (0 KB)  ( 11 )
57 Application effect of cognitive function training in the convalescent elderly
LIN Zhi-qiang1 LIN Jia-na2 LIN Zhi-wen3▲
Objective To explore the application effect of cognitive function training in the convalescent elderly.Methods A total of 100 convalescent elderly admitted to the Xiamen Army Special Service Center of PLA from January 2018 to December 2019 were selected as the research subjects and divided into the reference group and the observation group by even and odd grouping method, with 50 cases in each group. The reference group received routine education on admission, while the observation group received cognitive function training on the basis of the reference group.The total nursing satisfaction, cognitive function score before and after intervention and quality of life score were compared between the two groups. Results The total nursing satisfaction of the observation group (96.00%) was higher than that of the reference group (82.00%), and the difference was statistically significant (P＜0.05). The cognitive function scores after intervention including visual space and execution, naming, attention, language, abstract thinking, delayed recall, orientation and total score of the two groups were higher than those before intervention, and the differences were statistically significant (P＜0.05). The cognitive function scores including visual space and execution, naming, attention,language, abstract thinking, delayed recall, orientation and total score in the observation group after intervention were higher than those in the reference group,and the differences were statistically significant (P＜0.05). The scores of material life, emotional state, social life, physiological function scores in the observation group were higher than those of the reference group,and the differences were statistically significant(P＜0.05).Conclusion The cognitive function training in the convalescent elderly can significantly improve their cognitive function, which is worth of promotion and application.
2020 Vol. 27 (29): 57-29 [Abstract] ( 24 ) HTML (34 KB)  PDF  (0 KB)  ( 15 )
60 Causes and countermeasures of delayed treatment of testicular torsion
JIANG Qi-qi1 YE Lie-fu2▲ ZHANG Liang3 WU Xiang2 LIU Zhi-hua1
Objective To investigate the causes of delayed treatment of testicular torsion and to propose solutions.Methods The clinical data of 29 patients with testicular torsion who underwent orchiectomy due to delayed treatment and admitted to the Department of Urology of Fujian Provincial Hospital, Fujian Provincial Jinshan Hospital and Fuzhou Second Hospital from July 2010 to July 2020 were retrospectively analyzed. The average age of the patients was(16.86±2.07) years, ages 12-21 years. There were 21 cases on the left side and 8 cases on the right side, and 29 cases of delayed treatment were analyzed and summarized. Results All the 29 cases were treated with orchiectomy and the other side orchiopexy because of testicular exploration. The main causes of delayed treatment were lack of cognition in 17 cases (58.6%), misdiagnosis and missed diagnosis in 9 cases (31.0%), atypical symptoms in 2 cases (6.9%), false negative of color Doppler ultrasound results in 1 case (3.4%). Conclusion The main reasons for delayed treatment of testicular torsion are the lack of cognition, the lack of experience of the first doctor leading to missed diagnosis and misdiagnosis, atypical symptoms and false negative of color Doppler ultrasound results. The main countermeasures are to attach importance to education and strengthen publicity to improve the awareness of testicular torsion, to improve the professional level and experience of doctors, encourage the development of relevant scientific research, support the grass-roots to cooperate with the government to establish a sound medical system, to improve the early stage of patients with testicular torsion by implementing scrotal physical examination and scrotal color Doppler ultrasound in a short time to improve the early diagnosis rate of testicular torsion.
2020 Vol. 27 (29): 60-63 [Abstract] ( 24 ) HTML (31 KB)  PDF  (0 KB)  ( 16 )
64 Correlation between RANKL gene polymorphism and the incidence of atherosclerotic cerebral infarction
FAN Xue1 ZHAO Dong-xue2
Objective To explore the correlation between rs9533156 polymorphism of receptor activator for nuclear factor-κB ligand (RANKL) gene and the pathogenesis of atherosclerotic cerebral infarction. Methods From March 2018 to July 2018, a total of 213 patients diagnosed as atherosclerotic cerebral infarction in neurology department of Shengjing Hospital Affiliated to China Medical University were selected as the case group, and 197 healthy people in the physical examination center at the same time as the control group. Rs9533156 locus of RANKL gene was genotyped by improved multiple ligase reaction. Logistic regression analysis was used to investigate the correlation between RANKL gene polymorphism and the incidence of atherosclerotic cerebral infarction. Results There was no statistically significant difference in the genotype distribution of rs9533156 between the two groups (P>0.05); the comparison of the frequency of each allele was not statistically significant (P>0.05). Conclusions There is no significant correlation between the rs9533156 polymorphism of RANKL gene and the susceptibility of atherosclerotic cerebral infarction.
2020 Vol. 27 (29): 64-66 [Abstract] ( 28 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
67 Effect of Ziprasidone on glucose and lipid metabolism in patients with schizophrenia
CHEN Yu-hong
Objective To explore the effect of Ziprasidone on glucose and lipid metabolism in patients with schizophrenia. Methods A total of 120 patients with schizophrenia who were treated in our hospital from December 2017 to December 2019 were selected and divided into a control group (n=60) and a study group (n=60) according to the random number table method. In the control group, olanzapine was used for treatment, and in the study group, Ziprasidone was adopted. The body mass index (BMI), fasting blood glucose (FBG), 2 h postprandial blood glucose (2 h BG), fasting insulin (INS), insulin resistance index (HOMA-IR), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triacylglycerol (TG) of the two groups were measured before and 8-week after treatment. Results Before treatment,there were no significant differences in BMI, FBG, 2 h BG, INS, HOMAIR, TC, TG, LDL-C and HDL-C between the two groups (P＞0.05). The BMI, FBG, 2 h BG, INS, HOMA-IR, TC, TG and LDL-C of the control group were higher than those before treatment, the differences were statistically significant(P＜0.05). The difference of comparison on HDL-C before and after treatment in the control group was not statistically significant (P＞0.05). The differences in the comparisons on BMI, FBG, 2 h BG, INS, HOMA-IR, TC, TG, LDL-C and HDL-C before and after treatment in the study group were not statistically significant (P＞0.05). After treatment, the indicators of BMI, FBG, 2 h BG, INS, HOMA-IR, TC, TG and LDL-C in the study group were all lower than those in the control group, the differences were statistically significant (P＜0.05). There was no statistical difference in HDL-C between the two groups after treatment (P＞0.05). Conclusion Ziprasidone has no obvious influence on glucose and lipid metabolism in patients with schizophrenia. It is less likely to cause diabetes and glucose and lipid metabolism disorders in high safety and clinical applicability.
2020 Vol. 27 (29): 67-69 [Abstract] ( 24 ) HTML (34 KB)  PDF  (0 KB)  ( 11 )
70 Application effect of Naoxueshu oral liquid on patients with cerebral hemorrhage after minimally invasive drilling and drainage
WANG Hong-yu LI Hong-yu LI Gang
Objective To explore the effect of Naoxueshu oral liquid on cerebral hemorrhage after minimally invasive drilling and drainage. Methods A total of 80 patients with cerebral hemorrhage treated in our hospital from July 2016 to December 2019 were selected for study. According to the method of random touch, they were divided into two groups, 40 cases in the observation group and 40 cases in the control group. The patients in control group were treated with routine therapy, and the patients in observation group were treated with Naoxueshu oral liquid on the basis of routine therapy. The number of residual hematomas before treatment, 10 days after treatment and 15 days after treatment were compared between the two groups. The improvement of neurological function (National Institutes of Health Stroke scale, NIHSS） before and after treatment were compared between the two groups, and the clinical efficacy of the two groups after 3 weeks of continuous treatment were compared. Results After 10 and 15 days of treatment, the residual hematomas in the observation group were lower than that in the control group (P＜0.05), but there was no significant difference in NIHSS scores between the observation group and the control group before treatment (P＞0.05). After 3 weeks of treatment, the NIHSS scores of the observation group were significantly lower than that of the control group, and the ADL scores were significantly higher than that of the control group (P＜0.05), the differences were statistically significant(P＜0.05), and the total clinical effective rate was higher than that in the control group (P＜0.05). Conclusion The application of Naoxueshu oral liquid can not only shorten the course of disease, but also improve the condition of nerve function defect and improve the treatment efficiency.
2020 Vol. 27 (29): 70-73 [Abstract] ( 30 ) HTML (37 KB)  PDF  (0 KB)  ( 7 )
74 Clinical effect of Agomelatine combined with Aripiprazole in the treatment of major depressive disorder
LIANG Xiao-ling1 QIN Jun2
Objective To investigate the clinical effect and safety of Agomelatine combined with Aripiprazole in the treatment of major depressive disorder. Methods A total of 62 patients with major depressive disorder admitted to our hospital from January to December 2019 were divided into observation group and control group with 31 cases in each group according to the random principle. The patients in both groups were given 25-50 mg/d Agomelatine and taken at night. On this basis, the patients in observation group were given Aripiprazole 10-15 mg/d in the morning; the patients in control group were given placebo with similar appearance, the dosage method was the same as Aripiprazole, and the treatment lasted for 6 weeks. The clinical effect, HAMD score and TESS were compared before treatment and at the 2nd,4th and 6th week of treatment. Results The effective rate of treatment in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). There was no statistically significant difference in the HAMD scores between the two groups before treatment (P＞0.05); the HAMD scores of the two groups at each time point after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05);the HAMD scores of 4 weeks and 6 weeks were lower than those of the control group, and the differences were statistically significant (P＜0.05). Adverse reactions include dizziness, headache, dizziness, insomnia, nausea, drowsiness, dry mouth, tachycardia, and transient liver function abnormalities, there was no statistically significant difference between the two groups of the incidence of adverse reactions (P＞0.05). Conclusion The combination of Agomelatine and Aripiprazole is more effective in the treatment of major depressive disorder, the improvement of symptoms is more obvious,and there is no significant increase in adverse reactions, which has positive clinical significance and is worth promoting.
2020 Vol. 27 (29): 74-76 [Abstract] ( 54 ) HTML (32 KB)  PDF  (0 KB)  ( 14 )
77 Effect of Apatinib combined with Tegafur, Gimeracil and Oteracil Potassium on the levels of serum tumor markers, Th1 and Th2 cell factors in patients with late gastric cancer
ZHANG Hong
Objective To investigate the effect of Apatinib combined with Tegafur, Gimeracil and Oteracil Potassium on the levels of serum tumor markers, T helper cell 1 (Th1) and T helper cell 2 (Th2) cell factors in patients with late gastric cancer. Methods The clinical data of 80 patients with late gastric cancer who were admitted to our hospital from January 2017 to December 2019 were retrospectively analyzed and divided into the control group (treated by Tegafur,Gimeracil and Oteracil Potassium) and the observation group (treated by Apatinib combined with Tegafur, Gimeracil and Oteracil Potassium) according to treatment methods, with 40 cases in each group. The serum tumor markers (carcino-embryonic antigen [CEA], carbohydrate antigen 19-9 [CA19-9], carbohydrate antigen 72-4 [CA72-4]), Th1 (interleukin-2 [IL-2] and interferon-γ [IFN-γ]) and Th2 (interleukin-4 [IL-4] and interleukin-10 [IL-10]) cell factors between the two groups before and after treatment were compared. Results The levels of serum CEA, CA19-9, CA72-4,IL-4 and IL-10 in two groups after treatment were lower than those before treatment, and the levels of IL-2 and IFN-γ were higher than those before treatment, and the differences were statistically significant (P＜0.05). The levels of CEA,CA19-9, CA72-4, IL-4 and IL-10 in the observation group after treatment were lower than those in the control group,and the levels of IL-2 and IFN-γ in the observation group were higher than those in the control group, and the differences were statistically significant (P ＜0.05). Conclusion Apatinib combined with Tegafur, Gimeracil and Oteracil Potassium is effective in the treatment of late gastric cancer, it can regulate the levels of serum tumor markers, Th1 and Th2 cell factors in patients, and alleviate the clinical symptoms.
2020 Vol. 27 (29): 77-79 [Abstract] ( 25 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
80 Clinical study on electrocautery under bronchoscope combined with local drugs in the treatment of central lung cancer
LIU Jun-jie1 GAO Dan2 FENG Jun-ya1 KUANG Min1 LI Xun-ji1 CAI Lei-ji1
Objective To explore the clinical effect of electrocautery under bronchoscope combined with local drugs in the treatment of central lung cancer. Methods A total of 76 patients with incomplete central lung cancer who were treated in Jiujiang Third People′s Hospital from March 2017 to September 2019 were selected as the research object,and they were randomly divided into the control group and the observation group, 38 cases in each groups. The control group was given systemic intravenous therapy, the observation group was given electrocautery combined with local drug therapy. After one course of treatment, the effective rate of airway stenosis treatment, Karnofsky score and blood oxygen partial pressure (PaO2), forced expiratory volume in one second (FEV1), forced vital capacity (FVC) were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group(P＜0.05). The scores of Karnofsky, the level of PaO2, FEV1, FVC indicators of the observation group after 1 course of treatment were higher than those of the control group (P＜0.05). Conclusion Electrocautery under bronchoscope combined with local drugs in the treatment of central lung cancer is simple, tolerable, and safe. The combined local drugs have a significant effect and can significantly improve the clinical efficacy of central lung cancer.
2020 Vol. 27 (29): 80-82 [Abstract] ( 27 ) HTML (38 KB)  PDF  (0 KB)  ( 9 )
83 Clinical effect of Shengbai Formula Granules on prevention of leukopenia in breast cancer patients after chemotherapy
LIU Di-lin1 HUANG Zuo-chao1 LI Zhao-yan1 WANG Gang2 YE Hua-bin2
Objective To analyze the effect of Shengbai Formula Granules on prevention of leukopenia in breast cancer patients after chemotherapy. Methods From March 2018 to March 2020, forty breast cancer chemotherapy patients admitted to our hospital were selected as the research objects, and they were divided into research group and control group according to the random number table method, 20 cases in each group. The study group was treated with Shengbai Formula Granules one week before chemotherapy, and Recombinant Human Granulocyte Stimulating Factor Injection was given according to the condition of leukocyte suppression; the control group was treated with Recombinant Human Granulocyte Stimulating Factor Injection according to the condition of leukocyte suppression. The white blood cell count, clinical effective rate, usage rate of recombinant human granulocyte stimulating factor injection and incidence of adverse reactions were compared and analyzed. Results There was no significant difference in leukocyte count between the two groups on the 7th day of one chemotherapy course (P＞0.05); the leukocyte count of the study group was significantly higher than that of the control group on the 14th and 20th day (P＜0.05). After one course of chemotherapy, the total clinical effective rate of leukopenia in the study group was significantly higher than that in the control group (P＜0.05). The usage rate and adverse reaction rate of recombinant human granulocyte stimulating factor injection in the control group were higher than those in the study group (P ＜0.05). Conclusion Shengbai Formula granules can help improve the white blood cell count of patients with breast cancer chemotherapy, prevent and control leukopenia, reduce the use of Recombinant Human Granulocyte Stimulating Factor Injection, and alleviate adverse reactions during chemotherapy. It is suitable for clinical application and promotion.
2020 Vol. 27 (29): 83-86 [Abstract] ( 26 ) HTML (39 KB)  PDF  (0 KB)  ( 9 )
87 Clinical observation on the effect of superselective infusion of Sodium Bicarbonate combined with Papaverine through the target artery on chemoembolization of solid malignant tumor
ZHOU Quan1 WU Bin1 HU Ai-ping2
Objective To investigate the application effect of superselective infusion of Sodium Bicarbonate combined with Papaverine through the target artery on chemoembolization of solid malignant tumor. Methods A total of 60 patients with solid malignant tumor treated by chemoembolization in our hospital from January 2018 to March 2019 were selected as the research subjects and divided into the study group and the control group according to the random number table method, with 30 cases in each group. The study group was treated by chemoembolization+target artery superselective infusion of Sodium Bicarbonate combined with Papaverine, while the control group was treated by chemoembolization alone. The therapeutic effect, side effects of the two groups were compared. The survival and Karnofsky(KPS) scores after 6 and 12 months of follow-up of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There were no statistically significant differences in the incidence of leucopenia, gastrointestinal reaction, pain reaction and fever between the two groups (P＞0.05). There were no statistically significant differences in survival rate and KPS scores between the two groups after 6 and 12 months of follow-up (P＞0.05). The survival rate of the observation group after 12 months of follow-up was higher than that of the control group, and the KPS scores of the observation group after 6 and 12 months of follow-up were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Superselective infusion of Sodium Bicarbonate combined with Papaverine through the target artery can improve the therapeutic effect of chemoembolization for solid malignant tumors, improve the long-term survival rate and KPS score, and will not increase the side effects, which is worthy of clinical recommendation.
2020 Vol. 27 (29): 87-90 [Abstract] ( 20 ) HTML (37 KB)  PDF  (0 KB)  ( 11 )
91 Efficacy of Paclitaxel Liposome combined with Carboplatin in the treatment of ovarian cancer
LIAO Zhen-rong SHEN Chang-mei YU Ying▲
Objective To investigate the effect of Paclitaxel Liposome combined with Carboplatin in the treatment of ovarian cancer. Methods A total of 60 cases of ovarian cancer treated in our hospital from January 2017 to June 2019 were selected as the resrarch objects, and they were divided into the control group and the observation group according to the random number table method, 30 cases in each group. The control group received Paclitaxel combined with Carboplatin treatment, the observation group received Paclitaxel Liposome combined with Carboplatin treatment. The short-term prognosis, side effects and quality of life at the end of treatment were compared between the two groups.Results There was no significant difference in the total effective rate between the two groups at the end of treatment(P＞0.05). The incidence of nausea, vomiting, fatigue, muscle pain and rash in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The scores of body function, role function, cognitive function, emotional function and social function in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The efficacy of Paclitaxel Liposome is similar to that of Paclitaxel combined with Carboplatin in the treatment of ovarian cancer, but Paclitaxel Liposome has better safety and higher quality of life.
2020 Vol. 27 (29): 91-93 [Abstract] ( 24 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
94 Influence of Doula delivery on the stages of labor, pregnancy outcomes in primiparas and neonatal scores at different ages
CHENG Ji-hong YING Bao-pei LAN Xi-hong
Objective To investigate the influence of Doula delivery on the the stages of labor, pregnancy outcomes in primiparas and neonatal scores at different ages. Methods A total of 90 primiparas awaiting delivery who were admitted to our hospital from September 2018 to September 2019 were selected. They were divided into the control group (n=45)and the observation group (n=45) according to the random number table method. In the control group, 15 cases were under 25 years old, 15 cases were 25-＜30 years old, and 15 cases were over 30 years old. In the observation group, 15 cases were under 25 years old, 15 cases were 25-＜30 years old, and 15 cases were over 30 years old. The control group was given conventional delivery mode, and the observation group was given Doula delivery mode. The stages of labor in primiparas at different ages, degree of labor pain (visual analogue scale [VAS] score), the mode of delivery,pregnancy outcomes and the neonatal score were compared between the two groups. Results The stages of labor in primiparas, VAS score, and cesarean section rate in the observation group were all lower than those in the control group, the Apgar score of the neonates after delivery in the observation group was higher than that in the control group,and the differences were statistically significant (P＜0.05). The incidence of adverse pregnancy outcomes at sections of ＜25 years old and ≥30 years old in the observation group were lower than those in the control group, with statistical difference (P＜0.05). There was no significant difference in the incidence of adverse pregnancy outcomes between the two groups of primiparas aged 25-＜30 years old (P＞0.05). The stages of labor and the VAS scores of primiparas aged 25-＜30 years old were lower than those of ＜25 years old and ≥30 years old between the two groups, the Apgar scores of newborns of primiparas aged 25-＜30 years old were higher than those of ＜25 years old and ≥30 years old between the two groups, and the labor process of primiparas aged ≥30 years was lower than that of ＜25 years old between the two groups, the differences were statistically significant (P＜0.05). There was no significant difference in the VAS score and neonatal Apgar score between ＜25 years old and ≥30 years old in the two groups (P＞0.05). There was no significant difference in the incidence of adverse pregnancy outcomes in primiparas at different ages between the two groups (P＞0.05). Conclusion The implementation of Doula delivery has a certain effect on the delivery of primiparas of different ages, which can effectively reduce the adverse pregnancy outcomes, increase the natural delivery rate,and ensure the safety of mothers and infants.
2020 Vol. 27 (29): 94-97 [Abstract] ( 22 ) HTML (40 KB)  PDF  (0 KB)  ( 11 )
98 Clinical study of Low Molecular Weight Heparin Calcium to improve placental circulation in the treatment of oligohydramnios
WANG Shan LI Yue-fen
Objective To investigate the clinical effect of Low Molecular Weight Heparin Calcium on the treatment of oligohydramnios in pregnancy. Methods A total of 80 patients with oligohydramnios in the middle and late stages of pregnancy who were treated in our hospital from January 2018 to September 2019 were selected and divided by single and double drawing. The singular was the control group (n=40), the even number was the observation group (n=40). The control group was treated with intravenous fluid replacement, the observation group was treated with low-dose Low-Molecular Weight Heparin Calcium on the basis of the control group, amniotic fluid index, S/D value of umbilical artery blood flow, delivery mode and pregnancy outcome, delivery outcome before and after treatment were compared between the two groups. Results The amniotic fluid index in the observation group was higher than that in the control group, the S/D value of umbilical artery blood flow in the observation group was lower than that in the control group,the preterm birth rate, cesarean section rate and Apgar score ≤7 in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). The neonatal weight in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). Conclusion Low Molecular Weight Heparin Calcium can effectively improve the S/D value of umbilical artery blood flow AFI, improve the outcome of maternal and infant.
2020 Vol. 27 (29): 98-100 [Abstract] ( 19 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
101 Application of modified cotton soft tape fixation in children′s orotracheal intubation
XIAO Bing OUYANG Mei LYU Xu-ying ZENG Yong-mei
Objective To investigate the effect of modified cotton flexible tape fixation on transoral tracheal intubation in children. Methods From June 2018 to October 2019, 60 children treated with oral tracheal intubation were selected and divided into control group (n=30) and test group (n=30) according to the method of random number table. The patients in the control group were treated with modified cotton flexible tape. The test group was treated with modified cotton flexible adhesive tape, the displacement and prolapse of tracheal intubation, mucosal stress injury, oral cleanliness,complications, distance of tracheal intubation, parents′ satisfaction and satisfaction, preparation time and operation time of oral care between two groups were compared. Results The tracheal intubation displacement and prolapse in the test group was better than that in the control group, the incidence of mucosal pressure injury and complications was lower than that in the control group, the oral cleanliness was better than that in the control group, the operating time of tracheal intubation moving distance were shorter than that in the control group, and the satisfaction of parents was higher than that in the control group, the differences were statistically significant (P＜0.05). Conclusion The application of modified cotton-flexible tape fixation in pediatric transoral tracheal intubation has remarkable clinical effect.
2020 Vol. 27 (29): 101-103 [Abstract] ( 21 ) HTML (36 KB)  PDF  (0 KB)  ( 9 )
104 Influence study of cesarean section and vaginal delivery on postpartum pelvic floor tissue status and lower urinary tract function
YUAN Mao-yong ZHANG Hai-hua YANG Pu-lan WANG Man-lan ZHANG Bao-xiu CHENG Fang
Objective To explore the influence of cesarean section and vaginal delivery on postpartum pelvic floor tissue status and lower urinary tract function. Methods A total of 60 parturients admitted to our hospital from February 2018 to April 2019 were selected as the research objects. According to the different modes of delivery, they were divided into the control group (30 cases) and the study group (30 cases). The control group adopted vaginal delivery method,and the study group adopted cesarean section method. The indexes of pelvic floor electromyography, pelvic floor tissue state and lower urinary tract function were compared between the two groups at 6, 12 and 24 weeks postnatal. Results The lower urinary tract function indexes of the volume cystometric capacity (VMCC), bladder compliance (BC) and the rate of maximum urinary flow (RMF) in the two groups at 12 and 24 weeks postpartum were higher than those at 6 weeks postpartum, and the differences were statistically significant (P＜0.05). There were no significant differences in VMCC, BC and RMF between the two groups at 6, 12 and 24 weeks after delivery (P＞0.05). There were no significant differences in VMCC, BC and RMF between 12 weeks postpartum and 24 weeks postpartum in the study group (P＞0.05). There were no significant differences in VMCC, BC and RMF between 12 weeks postpartum and 24 weeks postpartum in the control group (P＞0.05). The pelvic floor tissue state indexes such as posterior urethral bladder angle (Ar and As) and bladder neck rotation angle (θ) after 12 weeks and 24 weeks postpartum in the two groups were lower than those at 6 weeks postpartum, and the differences were statistically significant (P＜0.05). The pelvic floor tissue state indexes such as θ, Ar and As in the study group at 6 and 12 weeks after delivery were lower than those in the control group, and the differences were statistically significant (P＜0.05). There were no significant differences in θ, Ar and As between the two groups at 24 weeks postpartum (P＞0.05). The work value, peak value, activity value of pelvic floor electromyography in the two groups at 12 and 24 weeks after delivery were higher than those at 6 weeks after delivery, and the differences were statistically significant (P＜0.05). The work value, peak value, vitality value of pelvic floor electromyography in the study group at 6 and 12 weeks after delivery were higher than those of the control group,and the differences were statistically significant (P＜0.05). There was no significant difference in work value, peak value and activity value between the two groups at 24 weeks postpartum (P＞0.05). Conclusion Compared with vaginal delivery, cesarean section has less short-term adverse effect on the state of pelvic floor tissue and pelvic floor myoelectric value, but there is no significant difference between them in a long time. In addition, the two delivery modes have less impact on the lower urinary tract function, therefore, it is necessary to select the appropriate delivery mode according to the actual situation of the pregnant women.
2020 Vol. 27 (29): 104-107 [Abstract] ( 20 ) HTML (35 KB)  PDF  (0 KB)  ( 10 )
108 Observation on therapeutic effect of lower uterine segment clamp combined with drug therapy in treatment of postpartum hemorrhage
DONG Chun-yan LIU Hai-mei▲ ZHANG Ji-hong LIAO Li-jun
Objective To explore the therapeutic effect of lower uterine segment clamp combined with drug therapy in the treatment of postpartum hemorrhage. Methods A total of 80 patients with postpartum hemorrhage admitted to our hospital from January 2018 to December 2019 were selected as research subjects and divided into the control group (n=40) and the observation group (n=40) by the random number table method. The control group was treated with drug therapy alone, while the observation group was treated with lower uterine segment clamp combined with drug therapy.The blood loss at 1, 2 and 24 h after delivery, the therapeutic effect, the hemostasis effect time, stay-in-hospital time,hemoglobin levels and blood transfusion status were compared between the two groups. Results The blood loss of the observation group at 1, 2 and 24 h after delivery was lower than that of the control group, and the difference was statistically significant (P＜0.05). The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05). The hemostasis effect time and the stay-in-hospital time of the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, the hemoglobin level of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05); while the hemoglobin level of the control group after treatment was lower than that before treatment, and the difference was statistically significant (P＜0.05). There was no significant difference in the hemoglobin level of the observation group between before and after treatment (P＜0.05). No blood transfusion was required in the observation group, while 4 cases occurred in the control group. The incidence of blood transfusion in the observation group was lower than that in the control group, with statistical difference (P＜0.05). Conclusion Lower uterine segment clamp combined with drug therapy is effective in the treatment of postpartum hemorrhage, which can shorten the hemostasis time and hospital stay time. It can also reduce postpartum hemorrhage, the influence on hemoglobin level, and the amount of blood transfusion. Therefore, it has high application value.
2020 Vol. 27 (29): 108-110 [Abstract] ( 21 ) HTML (34 KB)  PDF  (0 KB)  ( 7 )
111 Influence of systemic functional exercise combined with pelvic floor neuromuscular electrical stimulation on urinary retention in patients with gynecological malignant tumor after operation
ZHANG Li-ping XIE Hua HUANG Wen-ying RUAN Jun-yi LI Gui-mei
Objective To investigate the influence of systemic functional exercise combined with pelvic floor neuromuscular electrical stimulation on urinary retention in patients with gynecologic malignant tumors. Methods From October 2016 to November 2018, 48 patients with gynecological malignant tumors were selected as the subjects of study,and divided into the control group (n=24) and the observation group (n=24). The control group used conventional nursing program, the observation group used systemic functional exercise combined with basin neuromuscular electrical stimulation for rehabilitation care, the incidence of urinary retention, urinary catheter indwelling time, residual urine volume and nursing satisfaction were compared between two groups. Results The nursing total satisfaction rate of the observation group (95.83%) was higher than that of the control group (70.83%), the total incidence of urinary retention(16.67%) was lower than that of the control group (45.83%), and the catheter indwelling time was (53.41±10.52) h of the observation group, which was short than that in the control group of (68.59±11.62) h, the residual urine volume was(21.64±10.64) ml of the observation group, which was less than that of the control group of (41.03±11.86) ml, the differences were statistically significant (P＜0.05). Conclusion Systemic functional exercise combined with pelvic floor neuromuscular electrical stimulation can significantly reduce the probability of urinary retention in patients with gynecologic malignant tumors, shorten the retention time of the urethra and reduce residual urine volume, which has important clinical application significance.
2020 Vol. 27 (29): 111-113 [Abstract] ( 17 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
114 Clinical analysis of pregnancy diseases distribution and pregnancy outcomes in pregnant women with different ages
LI Ren-ren MENG Qing-yong WANG Huan WANG Jiao CHEN Ping
Objective To investigate the distribution of pregnancy diseases and pregnancy outcomes in pregnant women with different ages. Methods The clinical data of 11 358 pregnant women who delivered in our hospital from January to December 2019 were retrospectively analyzed. According to age, they were divided into the elderly group (≥35 years old) and the non-elderly group (＜35 years old), and the differences between the two groups in pregnancy diseases and pregnancy outcomes were compared. Results ①The rates of gestational diabetes, hypertensive disorders of pregnancy,anemia, scar uterus, oligohydramnios, hypothyroidism of the elderly group were higher than those of non-elderly group,with statistical differences (P＜0.05). The rates of premature rupture of membranes, fetal distress of the elderly group were lower than those of non-elderly group, with statistical differences (P＜0.05). There were no statistically significant differences between two groups in the rates among polyhydyamnios, intrahepatic cholestasis of pregnancy (ICP), placental abruption, placenta previa, obesity, hyperthyroidism (P＞0.05). ②The rates of postpartum hemorrhage, cesarean section and preterm delivery in the elderly group were higher than those in the non-elderly group, with statistical differences (P＜0.05). There were no statistically significant differences in the rates among macrosomia, small-for-gestational-age and asphyxia neonatorum (P＞0.05). Conclusion The complications of the elderly pregnant women during pregnancy are increased, the rate of cesarean section is high, pregnancy outcomes is poor, perinatal care should be strengthened in clinic.
2020 Vol. 27 (29): 114-116 [Abstract] ( 21 ) HTML (29 KB)  PDF  (0 KB)  ( 12 )
117 Clinical effect of Danshen Injection combined with Magnesium Sulfate Injection in gestational hypertension
ZHONG Ying-fu
Objective To explore the clinical effect of Danshen Injection combined with Magnesium Sulfate Injection in gestational hypertension (HDCP). Methods A total of 134 patients with HDCP in our hospital from January 2018 to July 2019 were selected as research objects and divided into observation group (n=67) and control group (n=67) by random number table method. The control group was treated with Magnesium Sulfate Injection, and the observation group was treated with Salvia Injection combined with Magnesium Sulfate Injection. The course of treatment was 10 days. The indexes of blood pressure (systolic pressure, diastolic pressure, and mean arterial pressure), 24-hour urinary protein content, delivery outcomes and complications were compared between the two groups. Results After treatment, the levels of systolic blood pressure, diastolic blood pressure, mean arterial pressure and 24-hour urinary protein content in the two groups were lower than before treatment (P＜0.05). After treatment, the levels of systolic blood pressure, diastolic blood pressure, mean arterial pressure and 24-hour urinary protein content in the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). The delivery outcome in the observation group was better than that of the control group, and the complications incidences of postpartum hemorrhage,contractility, premature babies and intrauterine distress were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion The treatment of Danshen Injection combined with Magnesium Sulfate Injection could control blood pressure and urinary protein in patients with HDCP, improve the natural delivery rate, and help improve pregnancy complications.
2020 Vol. 27 (29): 117-119 [Abstract] ( 21 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
120 Application effect of Flurbiprolol Ester combined with Propofol in painless transvaginal oocyte retrieval
QING Zhao-hui1，2，3 PENG Shao-qin1，2，3 XU Qing-wei1，2，3 XU Xiao-tong1，2，3
Objective To observe the aapplication effect of Flurbiprolol Ester combined with Propofol in painless transvaginal oocyte retrieval. Methods A total of 60 patients in Family Planning Hospital of Guangdong Province from October to December 2019 were selected as the study subjects, and they were divided into Flurbiprolol Ester combined with Propofol group (group F, n=30) and Propofol group (group B, n=30) according to the random number table method.The total amount of Propofol, the total time duration of anesthesia, the total time of operation, the total amount of Propofol supplementation, the number of intraoperative body movements, postoperative abdominal pain and postoperative adverse reactions were compared between the two groups. Results The total amount of Propofol, the total amount of Propofol supplementation in the group F were lower than those in the group B, with statistical differences (P＜0.05). The total time duration of anesthesia in the group F was shorter than that in the group B, with statistical difference (P＜0.05). The number of intraoperative body movements (10.0%), postoperative abdominal pain (6.7%) and incidence of adverse events (23.3%) in the group F were lower than those in the group B (23.3%, 16.7%, 46.7%), with statistical differences (P＜0.05). Conclusion Applicationc effect of Flurbiprolol Ester combined with Propofol in painless transvaginal oocyte retrieval is a relatively safe and effective method to reduce the total dosage of Propofol, the total amount of Propofol added, the body movement and respiratory inhibition, the incidence of postoperative abdominal pain，and shortening the patient waking hours
2020 Vol. 27 (29): 120-122 [Abstract] ( 20 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
123 Effect of Carboprost Tromethamine, Carboprost Methylate Suppository and Oxytocin in the treatment of postpartum hemorrhage
WANG Jia
Objective To study the clinical effects of Carboprost Tromethamine, Carboprost Methylate Suppository combined with Oxytocin in the treatment of postpartum hemorrhage. Methods A total of 56 patients suffering from postpartum hemorrhage admitted to our hospital from May 2017 to April 2019 were selected as the research subjects and divided into the observation group (n=28) and the control group (n=28) according to the random number table method. In the control group, conventional Oxytocin combined with Carboprost Methylate Suppository was used, and in the observation group, Carboprost Tromethamine was added on the basis of the control group. The bleeding volume before treatment, the bleeding volume at 2, 24 h after delivery, and the decrease in hemoglobin at 24 h were recorded.The overall response rate, the total incidence of adverse reactions and the changes of heart rate (HR), diastolic blood pressure (DBP), and systolic blood pressure (SBP) before and after treatment in the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The bleeding volume of the observation group at 2 h and 24 h after delivery and the decrease of hemoglobin at 24 h after delivery were less than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, the HR, SBP, and DBP of the observation group were higher than those of the control group, with statistical significance (P＜0.05). There was no statistical difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion In the treatment of patients with postpartum hemorrhage,Carboprost Tromethamine, Carboprost Methylate Suppository combined with Oxytocin can remarkably reduce the amount of postpartum hemorrhage in puerpera and stabilize the patient′s vital signs such as HR and blood pressure.The curative effect is remarkable, the safety is good.
2020 Vol. 27 (29): 123-125 [Abstract] ( 16 ) HTML (35 KB)  PDF  (0 KB)  ( 11 )
126 Effect of acupuncture combined with ultrashort wave and medium frequency electrotherapy in the treatment of temporomandibular joint disorders
ZHANG Qiu-fang1 YANG Xiao-hong2 YANG Juan3
Objective To investigate the effect of acupuncture combined with ultrashort wave and medium frequency electrotherapy in the treatment of temporomandibular joint disorders. Methods A total of 82 patients with temporomandibular joint disorders who were admitted to our hospital from August 2019 to February 2020 were selected as the research subjects and divided into treatment group and control group according to randomized double blind method,with 41 cases in each group. The control group was treated with acupuncture, and the treatment group was treated with acupuncture combined with ultrashort wave and medium frequency electrotherapy. The clinical efficacy, maximum active month opening, degree of clicking of joint and pain degree were compared between the two groups. Results After treatment for 10 d, the total effective rate of treatment group was higher than that of control group, and the difference was statistically significant (P＜0.05). After treatment for 10 d, the maximum active month opening of treatment group was larger than that of control group, and the degree of clicking of joint in treatment group was slighter than that in control group, and the differences were statistically significant (P＜0.05). After treatment for 10 d, the scores of visual analogue scale (VAS) in treatment group at rest state, at the end of month opening and on chewing were lower than those in control group, and the differences were statistically significant (P＜0.05). Conclusion Acupuncture combined with ultrashort wave and medium frequency electrotherapy in treatment of temporomandibular joint disorders can effectively improve the maximum month opening, decrease the degree of clicking of joint and pain, which has better clinical efficacy.
2020 Vol. 27 (29): 126-129 [Abstract] ( 20 ) HTML (37 KB)  PDF  (0 KB)  ( 13 )
130 In vitro study on the effect of different concentrations of Gallnut extract on streptococcus mutans
YU Jing DENG Wei▲
Objective To investigate the effect of different concentrations of Gallnut extract on streptococcus mutans.Methods The clinical data of 100 patients with caries who were treated in our hospital from June 2015 to January 2019 were retrospectively analyzed and divided into group A (rinse the mouth with fluoride mouth rinse, 40 cases), group B(rinse the mouth with 16 mg/ml Gallnut extract, 30 cases) and group C (rinse the mouth with 32 mg/ml Gallnut extract,30 cases) according to the different treatment methods. The saliva of the patients was taken to make bacterial culture medium before treatment and after treatment for 3 months. The number of streptococcus mutans colony in bacterial culture medium, the total incidence of adverse reactions and the recurrence rate during follow-up were compared among the three groups. Results The number of streptococcus mutans colony in bacterial culture medium in three groups after treatment was fewer than those before treatment, and the differences were statistically significant (P＜0.05). The number of streptococcus mutans colony in bacterial culture medium in group B and C after treatment was fewer than those in group A, and the differences were statistically significant (P＜0.05). The number of streptococcus mutans colony in bacterial culture medium in group C after treatment was fewer than that in group B, and the difference was statistically significant (P＜0.05). The total incidence rates of adverse reactions in group B and C were lower than those in group A, and the differences were statistically significant (P＜0.05). The recurrence rates during follow-up in group B and C were lower than those in group A, and the differences were statistically significant (P＜0.05). Conclusion Applying 32 mg/ml of high concentration of Gallnut extract to the clinical treatment of patients with caries can effectively decrease the number of streptococcus mutans colony, have a stronger antibacterial effect on streptococcus mutans, and reduce the incidence of adverse reactions and recurrence rate, which has higher safety and better curative effect.
2020 Vol. 27 (29): 130-133 [Abstract] ( 18 ) HTML (35 KB)  PDF  (0 KB)  ( 13 )
134 Application of nasal cavity irrigation after nasal endoscopy in relieving nasal ventilation
LU Hua HE Li-xing CHEN Zhi-fang WU Lu-jing JIANG Wan-fu
Objective To study the application of nasal irrigation after nasal endoscopy in relieving nasal ventilation.Methods A total of 150 patients underwent endoscopic sinus surgery admitted to our hospital from May 2017 to February 2020 were selected and randomly divided into two groups according to random number table method, with 75 cases in each group. The observation group was treated with nasal lavage fluid. The symptom score, visual analogue score(VAS) and Lund-Kennedy endoscopy score and treatment effect of the two groups were compared. Results The nasal congestion, runny nose, smell, headache, and cheek pain scores of the observation group after nasal endoscopy were lower than those of the control group, the differences were statistically significant (P＜0.05). The VAS score and Lund-Kennedy endoscopy score of the observation group after treatment were lower than those of the control group, the differences were statistically significant (P＜0.05). The total effective rate of the observation group after treatment was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Nasal irrigation after nasal endoscopy plays an important role in improving the efficacy of nasal ventilation, which is worthy of research and promotion.
2020 Vol. 27 (29): 134-136 [Abstract] ( 17 ) HTML (30 KB)  PDF  (0 KB)  ( 9 )
137 Exploration of inflammatory skin preservation during the operation of preauricular fistula in infection stage
JIANG Yuan-wei1 CAI Zhi-fu1 XIE Guan-feng2 FU Ting-ting3 HU Ping-ting3
Objective To explore the application effect of inflammatory skin preservation in the operation of preauricular fistula in the period of infection. Methods From January 2019 to January 2020, 50 patients with congenital preauricular fistula and abscess in the Department of Otolaryngology of Affiliated Hospital of Putian University and Putian Hanjiang Hospital were selected as the study objects. The patients were divided into the experimental group and the control group by stratified random sampling, 25 cases in each group. In the experimental group, the small fusiform incision was used and extended down 1 to 2 cm, and the inflammatory skin was preserved. In the control group, large fusiform or double fusiform incision was used. The patients were followed up for 1 month to 1 year. The therapeutic effect, the incidence rate of complication, local scar length and recurrence rate of the two groups were compared.Results The total effective rate of the experimental group was 88.00%, compared with 96.00% of the control group,there was no significant difference (P＞0.05). There was no significant difference in the total incidence of complications between the two groups (P＞0.05). The local scar length in the experimental group was (8.16±1.28) mm, which was significantly shorter than (18.08±1.73) mm in the control group, the difference was statistically significant (P＜0.05). The recurrence rate of the experimental group was 8.00%, compared with 4.00% of the control group, there was no significant difference (P＞0.05). Conclusion For the patients with congenital preauricular fistula and abscess stage, the same therapeutic effect can be achieved by using small fusiform incision after proper control of inflammation,supplemented by surgical techniques such as inflammatory skin preservation during the operation, which can improve the scar without increasing the recurrence rate.
2020 Vol. 27 (29): 137-139 [Abstract] ( 17 ) HTML (33 KB)  PDF  (0 KB)  ( 12 )
140 Clinical effect comparison of periodontal combined pulp therapy and periodontal therapy alone in severe periodontitis
CHEN Jian-guang WANG Xiao-yi

Objective To investigate the clinical effect of periodontal combined pulp therapy and periodontal therapy alone in severe periodontitis. Methods A total of 62 patients with severe periodontitis admitted to our hospital from January 2017 to January 2019 were selected as the research subjects and divided into the observation group and the control group according to the random number table method, with 31 cases in each group. The observation group was treated with periodontal combined pulp, while the control group was treated with periodontal alone. The periodontal bag probing depth (PPD), gum crevicular bleeding index (SBI), mobility (MD), plaque index (PLI) before and after treatment and therapeutic effect were compared between the two groups. Results There were no significant differences in PPD,SBI, MD and PLI between the two groups before treatment (P＞0.05). The PPD, SBI, MD and PLI of the two groups after treatment were lower than those before treatment, and the differences were statistically significant (P＜0.05). The PPD,SBI, MD and PLI of the observation group after treatment were lower than those of the control group, and the differences were statistically significant (P＜0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜0.05). Conclusion The clinical effect of periodontal combined pulp therapy in patients with severe periodontitis is superior to that of periodontal therapy alone,and it is worthy of promotion and application.
2020 Vol. 27 (29): 140-142 [Abstract] ( 18 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
143 Changes of maxillary sinus mucosal thickness in molars with severe periodontitis
FU Wei-zhuo
Objective To investigate the changes of maxillary sinus mucosa thickness corresponding to molars in patients with severe periodontitis. Methods From February 2017 to February 2019, patients with severe periodontitis treated by maxillary molar extraction were selected as the study group （n=14）, and patients with mild alveolar bone resorption in maxillary molars treated in the department of stomatology at the same time were selected as the control group（n=15）. The patients in both groups were examined by conical bundle CT (CBCT), the maximum thickness of maxillary sinus mucosa (maxMT) and the minimum alveolar bone height (minRRH) of molars were measured and compared between the two groups. And the proportion of mucosal thickening was counted. After 6 months of extraction of maxillary molar and site preservation, the changes of mucosal thickness of maxillary sinus in the study group were analyzed. Results The thickness of maxMT before treatment in the study group was higher than that in the control group,the proportion of mucosal thickening in the maxillary sinus was higher than that in the control group, the differences were statistically significant (P＜0.05); the minRRH before treatment in the study group was lower than that in the control group, the difference was statistically significant (P＜0.05). After molars extraction in the study group, the corresponding maxMT was significantly lower than before treatment, and the proportion of maxillary sinus mucosal thickening was lower than before treatment, the differences were statistically significant (P＜0.05). Conclusion The thickness of molars corresponding to maxillary sinus mucosa in patients with severe periodontitis is significantly increased, and the pathological thickening is significantly improved after simultaneous extraction site preservation.
2020 Vol. 27 (29): 143-145 [Abstract] ( 20 ) HTML (31 KB)  PDF  (0 KB)  ( 12 )
146 Effect of intravitreal injection of Ranibizumab on treatment of ocular fundus disease
ZHAN Tian-yin LIU Wei-dong
Objective To investigate the effect of intravitreal injection of Ranibizumab on treatment of ocular fundus disease. Methods A total of 100 patients with ocular fundus disease treated in our hospital from January 2018 to October 2019 were selected as the research subjects and divided into the control group and the observation group by random number table method, with 50 cases in each group. Patients in the control group were treated with conventional drugs, while patients in the observation group were treated with intravitreal injection of Ranibizumab on the basis of conventional drugs. The total effective rate, symptom disappearance time, clinical symptom improvement and hemodynamic indicators were compared between the two groups. Results The total effective rate in the observation group(92.00%) was higher than that of the control group (72.00%), and the difference was statistically significant (P＜0.05).The retinal edema disappearance time, normal retinal thickness recovery time, retinal hemorrhage disappearance time and neovascularity disappearance time of the observation group were shorter than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, the eyesight of the observation group was higher than that of the control group, the intraocular pressure and retinal thickness of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). After treatment, the whole blood viscosity, plasma viscosity, hematocrit and red blood cell aggregation index of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜0.05). Conclusion Intravitreal injection of Ranibizumab has a significant effect on treatment of ocular fundus disease and is worthy of clinical application and promotion.
2020 Vol. 27 (29): 146-148 [Abstract] ( 21 ) HTML (33 KB)  PDF  (0 KB)  ( 10 )
149 Clinical evaluation of pelvic floor dysfunction in women with different reproductive history by transperineal ultrasound
ZHU Hui-huan CHEN Hai-yan GAO Ying-chang
Objective To explore the diagnostic value of transperineal ultrasound for pelvic floor dysfunction in women with different reproductive history. Methods A total of 600 women patients who underwent transperineal ultrasound in our hospital from March 2019 to February 2020 were selected as the study objects. According to their reproductive history, they were divided into the non-fertility group (200 cases), the vaginal delivery group (200 cases) and the cesarean section group (200 cases). All patients underwent transperineal ultrasound examination, and the results of 2D ultrasound under resting state and 3D ultrasound under Valsalva action were recorded and analyzed. Results In the 600 women, there were 240 cases of pelvic floor dysfunction, and the positive rate was 40%. Among them, 135 cases were confirmed in the vaginal delivery group, 90 cases were confirmed in the cesarean section group, and 15 cases were confirmed in the non-fertility group. The positive rate of diagnosis in the vaginal delivery group were higher than those in the cesarean section group and the non-fertility group, and the differences were statistically significant (P＜0.05). The positive rate of diagnosis in cesarean section group was higher than that in non-fertility group, and the difference was statistically significant (P＜0.05). The descending distance of bladder neck, the descending distance of cervix uteri, the rotation degree of urethra, the area of pelvic diaphragmatic hiatus and the thickness of levator ani muscle in the vaginal delivery group and the cesarean section group were higher than those in the non fertile group, the values from bladder neck to the posterior lower edge of pubic symphysis and from cervix to posterior lower edge of pubic symphysis, and the thickness of pubic rectum muscle in the vaginal delivery group and the cesarean section group were lower than those in the non fertile group, the differences were statistically significant (P＜0.05). Conclusion Transperineal ultrasound has great clinical application value in the screening and diagnosis of pelvic floor dysfunction diseases in women, which is worthy of promotion and application.
2020 Vol. 27 (29): 149-151 [Abstract] ( 21 ) HTML (32 KB)  PDF  (0 KB)  ( 10 )
152 Diagnostic effect of color ultrasound and X-ray mammography in breast cancer screening
YUAN Fang LI Ning-shan CHEN Fei▲
Objective To explore the diagnostic effect and application value of color ultrasound and X-ray mammography in breast cancer screening. Methods The clinical data of 183 female patients with suspected breast cancer admitted to our hospital from August 2017 to August 2019 were analyzed retrospectively. According to different inspection methods, the observation objects were divided into three groups. A total of 60 patients were diagnosed by color ultrasound, 55 patients were diagnosed by mammography, and 68 patients were diagnosed by color ultrasound combined with mammography. All patients underwent pathological examination in our hospital, and pathological examination was taken as the gold standard for diagnosis. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the results of color ultrasound, mammography and combined diagnosis were compared. Results The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and accuracy of color ultrasound were 81.25%, 75.00%, 92.86%, 50.00% and 80.00%, respectively. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value and accuracy of mammography were 79.07%, 66.67%, 89.47%, 47.06% and 76.36%, respectively. The combined diagnostic sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the subjects of combined diagnosis were 98.33%, 87.50%, 98.33%, 85.70% and 97.05%, respectively. There were no significant differences of the sensitivity, specificity, positive predictive value, negative predictive value and accuracy between color ultrasound and mammography (P＞0.05). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of color ultrasound combined with mammography were higher than those of color ultrasound and mammography alone, the differences were statistically significant (P＜0.05). Conclusion The results of color ultrasound and mammography in breast cancer screening are similar. The sensitivity, specificity and accuracy of color ultrasound combined with mammography are significantly higher than those of color ultrasound and mammography alone. The results of color ultrasound and mammography have good consistency with pathological results,and have higher application value.
2020 Vol. 27 (29): 152-155 [Abstract] ( 15 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
156 Effect of CT imaging in the diagnosis of hypertensive cerebral hemorrhage
ZOU Ting-ting
Objective To explore the effect of computer tomography(CT)imaging in the diagnosis of hypertensive cerebral hemorrhage. Methods A total of 75 patients with suspected hypertensive cerebral hemorrhage admitted to our hospital from May 15, 2017 to May 15, 2018 were selected as the observation group, and 75 healthy participants for physical examinations in our hospital during the same period were selected as the control group. They were performed with CT examinations. The blood flow signal indicators such as blood flow (BF), blood volume (BV), permeability surface (PS) of the two groups were compared in order to evaluate the diagnostic accuracy of CT imaging diagnosis in determining the bleeding site and its diagnostic value. Results The blood flow signals such as BF, BV, and PS of the observation group were (23.96±5.71) ml/(100 g·min), (0.52±0.13) ml/100 g, and (0.56±0.09) ml/100 g, which were lower than those of the control group, (61.23±9.56) ml/(100 g·min), (2.56±0.42) ml/100 g, and (14.56±2.74) ml/100 g, respectively (P＜0.05). The accuracy rate of CT imaging in diagnosis of thalamic hemorrhage was 95.24%, that of hemorrhage of capsula externa was 87.50%, that of hemorrhage of capsula interna was 100.00%, that of hemorrhage of putamen was 94.74%, and that of hemorrhage of cerebellum area was 100.00%. The sensitivity, specificity, missed diagnosis rate, and misdiagnosis rate of CT diagnosis for hypertensive cerebral hemorrhage were 95.16%, 92.31%, 4.84% and 7.69%. Conclusion In the diagnosis of hypertensive cerebral hemorrhage, the use of CT imaging has a high diagnostic accuracy.
2020 Vol. 27 (29): 156-158 [Abstract] ( 18 ) HTML (31 KB)  PDF  (0 KB)  ( 13 )
159 Bibliometric analysis of the relevant research on the benefit finding in China
SUN Li-yuan1 LIANG Xiao-rong2
Objective To explore the current situation and existing problems of the relevant research on the benefit finding in China by applying bibliometrics method, so as to provide reference for further research and development trends. Methods A bibliometrics analysis was performed on the articles related to benefit finding in the databases of Wanfang Medical Network Database, China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Journal Database (VIP) from the establishment of database to January 2020. The excel 2016 and SPSS 20.0 were used to establish a literature database for analysis, and metrological statistics on the publication year, journals, regions, fund support, research methods and types, research objects and diseases of the literature was performed. Results A total of 75 articles were included. From 2013 to 2016, the number of publications accounted for only 20.0%, from 2017 to 2019 it accounted for 80.0%, and the volume of published papers was relatively increased. The number of papers mainly distributed in Anhui, Zhejiang, Henan and Jiangsu. The number of published papers from schools and hospitals was almost the same. Most of the studies were cross-sectional research designs, mainly quantitative and investigative research. About 70% of the research subjects were cancer patients. Conclusion Research on the benefit finding in China is still in the exploratory stage. The research methods and contents are relatively simple. Further research is needed,qualitative research and prospective research methods can be used for exploring in multiple perspectives.
2020 Vol. 27 (29): 159-162 [Abstract] ( 22 ) HTML (36 KB)  PDF  (0 KB)  ( 10 )
163 Analysis of the characteristics of acute spinal cord injury in the urbanrural fringe of Guangzhou
ZHANG Shao-peng1 CAO Lin-jie1 ZHOU Bing-quan1 ZHONG Cheng2▲
Objective To analyze the characteristics of acute spinal cord injury in the urban-rural fringe of Guangzhou.Methods The clinical data of 62 patients with acute spinal cord injury in the urban-rural fringe of Guangzhou admitted to the Luogang Red Cross Hospital of Guangzhou and cooperative hospitals from September 2013 to September 2018 were retrospectively analyzed, which included gender, age, etiology, occupation, degree of injury, etc. The results were obtained from statistical analysis SPSS 13.0. Results The age of the patients was (36.01±4.36) years old, and the male to female ratio was 2.68∶1, and 51.61% of the injuries were caused by falling from high altitudes, followed by traffic accidents accounting for 35.48%. The most common injury site was the cervical spine, accounting for more than 45.00%.Migrant workers accounted for 50% of the patients. Conclusion The proportion of males with acute spinal cord injury in the urban-rural fringe of Guangzhou is relatively high and high-altitude falling and traffic accident injuries are the two main causes. Compared with the epidemiological survey data of spinal cord injury in other regions of our country,the average age of spinal cord injury patients is relatively low. Occupants with the highest number of spinal cord injury are migrant workers and local farmers. Acute spinal cord injury in the urban-rural fringe has unique epidemiological characteristics and problems, which differs from the central urban area. In order to improve treatment and prevention of spinal cord injury, this should be taken into consideration when making emergency strategies and policies.
2020 Vol. 27 (29): 163-165 [Abstract] ( 18 ) HTML (35 KB)  PDF  (0 KB)  ( 11 )
166 Application of WeChat platform to assist humanistic care after occupational exposure of outpatient nurses
JIANG Chun-ying ZHANG Hua-xiu XU Liang
Objective To explore the application effect of WeChat platform to assist humanistic care after occupational exposure of outpatient nurses. Methods A total of 42 outpatient nurses with occupational exposure from January 2015 to December 2018 were selected, 21 exposed nurses from January 2015 to December 2016 were used as the control group, while 21 exposed nurses from January 2017 to December 2018 were used as the intervention group. The control group was given routine mode, and the intervention group adopted WeChat platform to assist humanistic care measures on the basis of control group. The self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of the two groups were compared. Results The SAS and SDS scores of the two groups after intervention were lower than those before intervention, and those in the intervention group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The application of WeChat platform to assist humanistic care for outpatient nurses after occupational exposure can improve their psychological state, alleviate bad emotions, thus improve work efficiency, and the effect is remarkable.
2020 Vol. 27 (29): 166-169 [Abstract] ( 20 ) HTML (39 KB)  PDF  (0 KB)  ( 10 )
170 Analysis of the occurrence status and risk factors of indwelling needle phlebitis in patients of oncology department of our hospital
CHEN Yu-ye1 ZHENG Jian-sheng2 CHEN Li-shan1
Objective To understand the occurrence status and risk factors of indwelling needle phlebitis in patients of oncology department. Methods A total of 361 cases of cancer patients in our hospital from August to December 2019 were selected by convenient sampling, and the self-made questionnaire on the occurrence and influence of indwelling needle phlebitis was used for investigation. Results Altogether 39.1% patients had phlebitis. Single factor analysis showed that there were significant differences in the incidence rates of phlebitis among patients with different retention time, puncture site, chemotherapy drugs, high osmotic pressure drugs, strong acid and strong alkali drugs, types of flushing and sealing fluid, and administration frequency (P＜0.05). Multivariate analysis showed that the long duration of indwelling, location of puncture was forearm, use of hypertonic drugs and frequency of drug administration were risk factors of the incidence of phlebitis, and the use of chemotherapeutics was a protective factor for the occurrence of phlebitis caused by indwelling needle in patients with oncology department (P＜0.05). Conclusion The incidence of phlebitis is relatively high in the use of indwelling needle in oncology department, which is related to the factors such as long indwelling time, hypertonic and osmotic drugs and multi frequency infusion.
2020 Vol. 27 (29): 170-173 [Abstract] ( 19 ) HTML (35 KB)  PDF  (0 KB)  ( 9 )
174 Investigation on the current situation and influencing factors of doctors suffering from workplace violence in a grade-A first-class hospital in Hu′nan Province
MING Zhi1,2 MA Jing1,2▲ CHEN Xi2 HU Jia-wen1,2
Objective To understand the situation, characteristics and risk factors of doctors suffering from workplace violence in a grade-A first-class hospital in Hu′nan Province, and put forward corresponding countermeasures according to the current situation and risk factors of workplace violence in the hospital. Methods A total of 583 doctors in a grade-A first-class hospital in Hu′nan Province were selected as the research objects in July, 2019, and their basic information, work-related situation, physical and mental health status and workplace violence from which they suffered in the year from July 2018 to July 2019 were investigated through questionnaire survey. Results Among the 583 doctors surveyed who mainly worked in the department of internal medicine, 358 doctors suffered from workplace violence,mainly verbal violence during the day in wards and doctor′s offices, with an incidence rate of 61.41%. The reasons for the violence were mainly the unsatisfactory curative effect and the long waiting time for treatment. When the violence occurred, most doctors were making the rounds of the wards and rescuing patients. Logistic regression analysis results showed that the department of pediatrics (β=1.23, OR=1.41, 95%CI=1.04-11.24), emergency department (β=2.60, OR=3.06, 95%CI=2.95-58.73), weekly working hours of 46-65 h (β=0.58, OR=1.78, 95%CI=1.15-2.76), weekly working hours＞65 h (β=0.91, OR=2.47, 95%CI=1.42-4.31), poor health status (β=0.99, OR=2.68, 95%CI=1.31-5.47) and suffering from mental illness (β=0.90, OR=2.46, 95%CI=1.51-4.02) were the risk factors of doctors suffering from workplace violence (P＜0.05). Conclusion The incidence rate of workplace violence in this hospital is high. The hospital should take preventive measures for key departments, shorten the time for consultation, arrange doctors′ working time reasonably, and ensure the physical and mental health of doctors, so as to reduce the incidence rate of workplace violence in hospitals.
2020 Vol. 27 (29): 174-179 [Abstract] ( 19 ) HTML (45 KB)  PDF  (0 KB)  ( 11 )
180 Research on the application of quality control circle in the management of reducing the drug cost index of assistant medication
WEN Wei1 LIU Yan-qing1 LI Zheng1 LIU Li-ying1 LI Xiao-lan1 LUO Li2▲
 Objective To investigate the application of quality control circle in the management of assistant medication,aiming to reduce its drug cost index and improve the rational drug use in the clinic. Methods The data of assistant medication from January to April 2019 in Maternity and Child Care Hospital of Ganzhou City were analyzed by plato and fishbone diagram and 80/20 rule for finding the causes of improper use of assistant medication around the topic"reducing the drug cost index of assistant medication" after structuring quality control circle. Education, informationbased means, administrative intervention and post-prescription comment were formulated and implemented in quality control circle from June to December 2019. The utilization and income of assistant medication and the progressive rate of circle members were compared before and after the quality control circle. Results The utilization and income of assistant medication decreased from 78.95% before quality control circle to 65.81% after quality control circle, and the income of assistant medication decreased from 14.86% before quality control circle to 6.84% after quality control circle, below the target value (7.30%), while the rate of goal achievement was 106.00% and the rate of improvement was 53.93%. The progressive rate of circle members increased positively significantly, while their ability to solve problems and enthusiasm for learning were increased most obviously. Conclusion The quality control circle is worthy of promotion for reducing the drug cost index of assistant medication, improving the rational drug use in the clinic and improving the medical quality continuously.
2020 Vol. 27 (29): 180-184 [Abstract] ( 20 ) HTML (43 KB)  PDF  (0 KB)  ( 10 )
185 Application research of target management method in the construction of nurses′ core competence in operating room
SHI Gui-mei ZHANG Wei XIONG Ying
Objective To explore the application effect of goal management method in the construction of nurses′ core competence in operating room. Methods A total of 50 full-time nurses, rotating nurses and intern nurses in our operating room from June 2016 to December 2018 were selected as the research objects. The training and practice based on the target management method were concentrated on the implementation of the training for 3 months. The ability scale score before and after training, the nurses′ examination results (basic theory assessment and practical operation assessment score) were compared. Results After 3 months of training, nurses′ emergency and problem-solving abilities, specialist knowledge and operational skills, collaborative communication skills and interpersonal relationships, teaching and research abilities, laws and regulations and related professional knowledge, management abilities and their basic ability scores were higher than training before, the differences were statistically significant (P＜0.05); after the training,the nurses′ examination results were higher than before the training, the differences were statistically significant (P＜0.05). Conclusion The goal management method has a good effect in the construction of nurses' core competence in the operating room. It can significantly improve their core competence and the overall scores of the theory and practice of comprehensive exit examinations.
2020 Vol. 27 (29): 185-187 [Abstract] ( 19 ) HTML (32 KB)  PDF  (0 KB)  ( 12 )
188 Operating room nursing management of Reproduction Center under COVID-19 epidemic
ZHANG Xin GUO Shuai-shuai CHENG Zhao-xia XU Lu LIU Li-ying▲
To prevent COVID-19 infection, the operating room of the Reproduction Center has formulated corresponding plans and procedures in accordance with relevant national policies and based on the COVID-19 prevention and treatment guidelines and regulations. All staff were trained and received pre-service assessment. The nursing management was carefully arranged in many aspects including the nursing staff surgical protection, nursing staff care, surgical environment preparation and disinfection, medical waste treatment, protective materials management, health education and management on patients and so on. A total of 186 cases of surgery were successfully completed from February to March in 2020, and there were no medical staff or patients infected. The quality of nursing services and the safety of patients and medical staff were guaranteed. Scientific and comprehensive nursing management and control during COVID-19 epidemic is of great significance for improving surgical efficiency and reducing cross-infection rate.
2020 Vol. 27 (29): 188-190 [Abstract] ( 21 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
191 Application effect of detail thinking management method in psychiatric nursing management
JIANG Jian-mao1 CHEN Ze-qun2 CHEN Ze-ying3 WU Guang-bing4
Objective To discuss the application effect of detail thinking management method in psychiatric nursing management. Methods A total of 130 psychiatric patients in Guangzhou Civil Affairs Bureau Psychiatric Hospital from October 2017 to September 2019 were selected as research objects, they were divided into observation group (65 cases)and control group (65 cases) according to the method of random number table. Patients in the control group were given routine nursing management, and patients in the observation group were given detail thinking nursing management on the basis of the control group. The scores of nursing management quality, nursing satisfaction and the incidence of adverse events were compared between the two groups before and after nursing. Results There were no differences in the quality of nursing management (basic nursing quality, nursing document quality, nursing skill quality, safety nursing quality and goods management quality) between the two groups before intervention (P＞0.05). After intervention, the scores of nursing quality management in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The incidence of adverse events in the observation group was 4.62%, it was lower than that in the control group which was 18.46%, and the difference was statistically significant(P＜0.05). The nursing satisfaction of the observation group was 92.31%, it was higher than that in the control group which was 78.46%, and the difference was statistically significant (P＜0.05). Conclusion The application of detail thinking management method in psychiatric nursing management can help to improve the quality of nursing management and patients′ satisfaction with nursing work, reduce the occurrence of adverse events, which is worthy of clinical reference.
2020 Vol. 27 (29): 191-194 [Abstract] ( 23 ) HTML (36 KB)  PDF  (0 KB)  ( 7 )
195 Effect of nursing risk management based on the idea of circulation quality control on satisfaction and adverse reactions of outpatients with transfusion
ZHAN Xia-fang1 LI Jun-feng2
Objective To explore the influence of nursing risk management based on the concept of circular quality control on the satisfaction and adverse reactions of outpatient infusion patients. Methods From July 2018 to December 2019, a total of 100 patients who were infused in the outpatient infusion room of Fuzhou Maternal and Child Health Care Center were selected as the study objects, and randomly divided into two groups by random number table methods, each group had 50 cases. Satisfaction and adverse reactions were compared between the two groups. Results The service attitude, puncture technique, and infusion environment satisfaction scores of the observation group ([4.13±0.42]points, [4.32±0.32] points, [4.15±0.59] points) were higher than those of the control group ([3.82±0.24] points, [3.98±0.27] points, [3.84±0.31] points], the differences were statistically significant(P＜0.05). The total incidence of adverse reactions in the observation group (6.00%) was lower than that in the control group (20.00%), and the difference was statistically significant (P＜0.05). Conclusion The nursing risk management based on the idea of circular quality control can effectively improve the satisfaction of outpatients with transfusion, reduce the incidence of adverse reactions and the conflicts between doctors and patients, which is worthy of clinical application.
2020 Vol. 27 (29): 195-197 [Abstract] ( 15 ) HTML (33 KB)  PDF  (0 KB)  ( 9 )
198 Effect of family collaborative care model on cognitive function and quality of life of patients with mild to moderate senile dementia
CUI Wen-yan
Objective To explore the effect of family collaborative care model on cognitive function and quality of life of patients with mild to moderate senile dementia (AD). Methods A total of 60 patients with first mild to moderate AD admitted to our hospital from October 2018 to September 2019 were selected as the study subjects. The intervention method of family collaborative care model was implemented for 6 months. The Chinese version of the mini-mental state examination (MMSE) and the quality of life-Alzheimer′s disease scale (QOL-AD) were used to evaluate the cognitive function and quality of life of patients with AD before and after intervention. Results After the intervention, the scores of cognitive function directionality, memory, attention and computation, recall, language in senile AD patients and total score of MMSE were higher than before the intervention, and the differences were statistically significant (P＜0.05). After the intervention, the scores of each item in the quality of life and and its total scores were higher than before the intervention, and the differences were statistically significant (P＜0.05). Conclusion The intervention method of family collaborative care model can improve the cognitive function of patients and their quality of life with first mild and moderate AD.
2020 Vol. 27 (29): 198-201 [Abstract] ( 19 ) HTML (35 KB)  PDF  (0 KB)  ( 8 )
202 Application of graded nursing intervention in the treatment of diabetic foot ulcer with negative pressure closed drainage
HE Qin ZHANG Xiao-qing▲
Objective To explore the application value of graded nursing intervention in the treatment of negative pressure closure drainage (VSD) treatment in patients with diabetic foot ulcer. Methods A total of 100 patients with diabetic foot ulcer admitted to our hospital from January 2018 to June 2019 were selected as the research objects. They were divided into control group and experimental group according to the random number toble method，each had 50 cases.All patients were treated with VSD treatmend, the control group developed basic nursing strategies, and the experimental group carried out graded nursing intervention. Blood glucose before and after meal, patient′s recognition of nursing mode and wound healing were compared between the two groups. Results There were no significant differences in blood glucose before and after nursing in the control group (P＞0.05); the blood glucose index of patients in the experimental group after nursing was lower than that before nursing, and the difference was statistically significant (P＜0.05).There was no significant difference in blood glucose index between the two groups before nursing (P＞0.05); the blood glucose index of the experimental group after nursing was lower than that of the control group, and the difference was statistically significant (P＜0.05). Scores of foot care skills, verbal communication skills and nursing service attitude in the experimental group were higher than those in the control group, with statistically significant differences (P＜0.05).The formation time of peripheral granulation, scavenging time and basal granulation in the experimental group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion The implementation of VSD treatment and graded nursing intervention in patients with diabetic foot ulcer has certain application value, which can effectively stabilize and control the patient′s blood glucose, promote the formation of granulation tissue of the affected limb, build a good nurse-patient relationship, and thus obtain the recognition of patients on graded nursing intervention.
2020 Vol. 27 (29): 202-205 [Abstract] ( 17 ) HTML (39 KB)  PDF  (0 KB)  ( 12 )
206 Application effect of seamless integrated rescue mode in patients with acute stroke
WANG Su-xian LIU Hua-zhi▲
Objective To investigate the application effect of seamless integrated rescue mode in patients with acute stroke (CVA). Methods A total of 81 patients with acute CVA admitted to our hospital from August 2017 to December 2019 were selected as research objects. They were randomly divided into the observation group (n=41) and the control group (n=40). The control group adopted the conventional rescue mode, and the observation group adopted the integrated rescue mode. Pre-hospital emergency time, in-hospital emergency time, treatment success rate, accident incidence and satisfaction between two groups were compared. Results The pre-hospital and in-hospital treatment time of the observation group was shorter than that of the control group, the success rate of treatment was higher than that of the control group, and the total incidence of accidents was lower than that of the control group, the total degree of satisfaction was higher than that of the control group, the differences were statistically significant (P＜0.05). Conclusion Seamless integrated rescue mode can improve the rescue success rate of acute CVA patients, shorten the pre-hospital emergency treatment time and in-hospital treatment time, and improve the satisfaction.
2020 Vol. 27 (29): 206-208 [Abstract] ( 17 ) HTML (34 KB)  PDF  (0 KB)  ( 9 )
209 Application effect of the standard interaction theory in the nursing of patients with depression
HUANG He-long
Objective To explore the application effect of the standard interaction theory in the nursing of patients with depression. Methods A total of 60 patients with depression who were treated in our hospital from September 2018 to September 2019 were selected as the research subjects. They were divided into control group and observation group by random number table method, 30 cases each group. In the control group, routine nursing was used, while in the observation group, on this basis nursing intervention based on the theory of standard interaction was adopted. The degree of depression, medication compliance, and mastery of health knowledge before and after nursing were compared between the two groups. The nursing satisfaction was investigated. Results Before nursing, the Hamilton depression scale(HAMD) score between the groups were not displayed statistically (P＞0.05). After nursing, the HAMD score in the observation group was (14.47±3.22) points, lower than that of the control group of (17.24±3.48) points, and the difference was statistically significant (P＜0.05). The medication compliance of the observation group was 96.67% (29/30), higher than that of the control group accounting for 70.00% (21/30) (P＜0.05). The health knowledge mastery score in the observation group was (90.52±5.63) points, higher than the control group of (83.69±5.74) points, with statistical difference(P＜0.05). In the observation group, the total satisfaction was 100.00% (30/30), higher than that of the control group accounting for 80.00% (24/30), and the difference was statistically significant (P＜0.05). Conclusion The implementation of the standard interaction theory as an intervention for patients with depression can effectively improve their depression, and increase their compliance with medication and their knowledge of health. The nursing effect is remarkable and the satisfaction is high, which is worthy of clinical promotion.
2020 Vol. 27 (29): 209-212 [Abstract] ( 16 ) HTML (36 KB)  PDF  (0 KB)  ( 13 )
213 Effect of holistic continuous nursing intervention on the rehabilitation of patients with femoral neck fracture
ZENG Xiao-ping XU Zhe-ping
 Objective To explore the effect of overall continuous nursing intervention on the rehabilitation effect of patients with femoral neck fractures. Methods A total of 52 patients with femoral neck fractures who were treated in our hospital from December 2017 to June 2018 were selected as research objects. They were divided into control group (n=26) and observation group (n=26) according to the random number table method. The control group was given routine orthopedic nursing intervention, the observation group adopted overall continuous nursing intervention, and the hip and knee function scores, complication rate, anxiety and depression scores, and quality of life scores were compared between the two groups. Results The scores of hip and knee function in observation group were higher than those in control group at 12 months after intervention, the differences were statistically significant (P＜0.05); the incidence of postoperative complications in observation group was 11.54%, lower than that in the control group of 38.46%, the difference was statistically significant (P＜0.05). The anxiety and depression scores before nursing were not statistically significant (P＞0.05), and the anxiety and depression scores of the observation group were lower than those of the control group after nursing 12 months, and the differences were statistically significant (P＜0.05). Conclusion The overall continuous nursing mode for patients with femoral neck fractures is helpful for the effective recovery of joint function and reduces the incidence of clinical complications.
2020 Vol. 27 (29): 213-215 [Abstract] ( 20 ) HTML (32 KB)  PDF  (0 KB)  ( 13 )
216 Application effect of whole-course psychological intervention in perioperative period of cataract surgery
ZHANG Nan JIANG Dan-dan
Objective To investigate the application effect of whole-course psychological intervention in perioperative period of cataract surgery. Methods A total of 160 cases of cataract surgery patients admitted to our hospital from May 2018 to May 2019 were selected as the research objects. According to the random number table method, they were divided into the reference group (n=80) and the research group (n=80). The reference group received routine nursing, and the research group received whole-process psychological nursing on the basis of the reference group. The postoperative mental health status, complications, satisfaction and life quality of the two groups were compared. Results After surgery, Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) scores of patients in the research group were lower than that of the control group, scores of life quality index were higher than that of the control group,postoperative total complication rate was lower than that of the control group, and total satisfaction rate of nursing was higher than that of the control group, with statistical differences (P ＜0.05). Conclusion Psychological treatment of cataract surgery patients can effectively improve their anxiety and depression, satisfaction, quality of life, and reduce the incidence of postoperative complications.
2020 Vol. 27 (29): 216-218 [Abstract] ( 21 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
219 Application of targeted nursing in lower extremity deep vein thrombus after laparoscopic appendectomy in elderly patients with acute appendicitis
WANG Li-xia
Objective To analyze the application value of targeted nursing care in elderly patients with acute appendicitis after laparoscopic appendectomy (LA) in the lower thrombosis. Methods A total of 80 elderly patients with acute appendicitis who underwent LA in our hospital from October 2018 to October 2019 were selected and divided into control group (n=50) and study group (n=50) according to the pattern of odd and even numbers, the control group received routine nursing and the study group received targeted nursing. The incidence of lower extremity thrombosis, the levels of D-Dimer(D-D), fibrinogen (FIB) and satisfaction with nursing care were compared between the two groups at 1, 3 and 7 days after operation. Results The incidence of lower limb thrombosis in the study group was lower than that in the control group (P＜0.05). There was no significant difference in D-D level between the two groups on the 1st day after operation (P＞0.05), but the D-D level of the study group at 3 and 7 d after operation was lower than that of the control group (P＜0.05). The level of FIB in the study group at 1, 3 and 7 d postoperatively was lower than that in the control group (P＜0.05). The total satisfaction of nursing in the study group was higher than that in the control group (P＜0.05).Conclusion The application of targeted nursing care in elderly patients with acute appendicitis after LA is helpful to prevent the formation of lower limb thrombosis and promote the early recovery after appendectomy.
2020 Vol. 27 (29): 219-221 [Abstract] ( 19 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
222 Application effect of operating room detail nursing in patients with colon cancer surgery
LIU Li-ping MA Wen-jing
Objective To explore the application effect of operating room detail nursing in patients with colon cancer surgery. Methods A total of 90 patients with colon cancer who underwent surgical treatment from July 2018 to January 2020 in our hospital were selected and divided into experimental group (n=45) and control group (n=45) according to random number table method. The control group was given routine nursing, the experimental group was given detailed nursing care in the operating room. The quality of care, the occurrence of complications, the occurrence of operating room risk, and the satisfaction of nursing between the two groups were compared. Results The experimental group′s skill proficiency was(18.13±1.62)points,equipment preparation was(18.89±0.55)points,environmental score was(17.59±1.52) points, cleaning and disinfection was (19.95±1.25) points, which were higher than those of the control group of(13.37±1.74), (13.26±1.31), (12.71±1.39) and (14.17±1.93) points, the differences were statistically significant (P＜0.05).The total incidence of complications in the experimental group (4.44%) was lower than that in the control group(24.44%), the difference was statistically significant (P＜0.05), the incidence of operating room risk in the experimental group (6.67%) was lower than that in the control group (46.67%), the difference was statistically significant (P＜0.05);nursing total satisfaction in the experimental group (93.33%) was higher than that in the control group (68.89%), the difference was statistically significant (P＜0.05). Conclusion Operating room detail nursing applied to patients with colon cancer surgery can effectively improve the quality of care, reduce the occurrence of complications, reduce the risk of operating room, and improve the satisfaction of nursing, so it is worth popularizing and applying.
2020 Vol. 27 (29): 222-224 [Abstract] ( 19 ) HTML (31 KB)  PDF  (0 KB)  ( 14 )
225 Application effect of early limb function training in nursing of patients with cerebral infarction
YANG Meng
Objective To explore the effect of early limb function training in the nursing of patients with cerebral infarction (CVA). Methods Ninety patients with CVA treated in our hospital from January to December 2019 were selected. They were divided into the observation group and the control group according to random number table method,45 cases in each group. The control group was given routine nursing, the observation group in the control group on the basis of was given early limb function training. The daily living ability, neurological changes, satisfaction with nursing services, body balance, and trunk control between the patients of two groups were compared. Results After the intervention, the Fugl-Meyer balance scale, Sheikh torso control scale, and Barthel index scores in the observation group were higher than those in the control group (P＜0.05). The neurological deficit (NIHSS) score of the observation group was lower than that of the control group, and the difference between the groups was statistically significant (P＜0.05).The total satisfaction of the patients in the observation group with the nursing service was higher than that of the control group, the difference was statistically significant (P＜0.05). Conclusion The early limb function training for patients with CVA is ideal, which is helpful to improve the degree of neurological deficits, improve the ability of daily living,improve the relationship between nurses and patients, and can be promoted and used.
2020 Vol. 27 (29): 225-227 [Abstract] ( 20 ) HTML (31 KB)  PDF  (0 KB)  ( 10 )
228 Application effect of psychological nursing in prenatal fetal heart monitoring
CHENG Lin
Objective To explore the application effect of psychological nursing in prenatal fetal heart monitoring.Methods 130 cases of pregnant women with fetal heart monitoring admitted to our hospital from June 2018 to October 2019 were selected as observation objects. According to the order of treatment, the pregnant women were divided into control group (n=65) and observation group (n=65). The control group was prepared for fetal heart monitoring according to the conventional process, checked the data of pregnant women, and paid close attention to the monitoring process.The observation group was given psychological care on the basis of conventional care, and the psychological state,nursing compliance and nursing satisfaction of the pregnant women before and after nursing intervention were observed between the two groups. Results After nursing, the scores of Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD) of the two groups were lower than those before nursing, with statistical differences (P＜0.05), the scores of HAMA and HAMD of the observation group were lower than those in the control group, with statistical differences (P＜0.05). The total nursing compliance of the observation group was 92.31%, and that of the control group was 76.92%,the total compliance of the observation group was higher than that in the control group, and the difference was statistically significant (χ2=5.905, P=0.015). The nursing total satisfaction of the observation group was 93.85%, and that of the control group was 80.00%, the total satisfaction of the observation group was higher than that in the control group,and the difference was statistically significant (χ2=5.482, P=0.019). Conclusion The implementation of psychological nursing in prenatal fetal heart monitoring can effectively improve the psychological state of the parturient and improve the compliance and satisfaction of the parturient.
2020 Vol. 27 (29): 228-230 [Abstract] ( 20 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
231 Effect of systematic nursing intervention on self-management ability of patients with peripherally inserted central catheter in primary hospitals
LIU Guang-ping ZHANG Jian-xin
Objective To explore the effect of nursing intervention on the self-management ability of peripherally inserted central catheter (PICC) patients in primary hospitals. Methods A total of 40 patients who underwent PICC catheterization in our hospital from January to December 2018 and who were hospitalized for the first time were selected as intervention group. A total of 46 patients who underwent PICC catheterization in external hospital from January to December 2018 and who were hospitalized for the first time were selected as control group. The intervention group received systematic nursing intervention, the control group received health education from the hospital. Self management ability of PICC and incidence of catheter complications between the two groups were compared. Results The self-management ability of the intervention group was (152.11±4.51) points, higher than that of the control group of (125.48±6.61) points, and the scores of daily catheter observation, catheter maintenance compliance, catheter management confidence, abnormal situation handling, information acquisition, exercise with catheter, daily life with catheter were higher than those of the control group, the differences were statistically significant (P＜0.05). The total incidence of catheter complication in the intervention group (5.00%), which was lower than that of the control group (19.57%), and the difference was statistically significant (P＜0.05. Conclusion Systematic nursing interventions have positive effect on improving the self-management ability of catheters in PICC patients and reducing the incidence of catheter complications.
2020 Vol. 27 (29): 231-233 [Abstract] ( 22 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
234 Effect of Orem self-care mode on self-care ability and the incidence of hypoglycemia in senile patients with diabetes
HONG Mei-juan
Objective To investigate the effect of Orem self-care mode on self-care ability and the incidence of hypoglycemia in senile patients with diabetes. Methods 60 senile patients with diabetes who were admitted to our hospital from January 2018 to January 2020 were selected as the research subjects. All selected cases were divided into control group (n=30) and research group (n=30) according to random number table method. The control group was given routine nursing intervention, and research group was given Orem self-care mode intervention on the basis of control group. The self-care ability, awareness rate of disease-related knowledge (drug knowledge, dietary principle, complications), hypoglycemia and health behavior (medication compliance, moderate exercise and blood glucose control) were compared between the two groups. Results The score of self-care ability in the research group was higher than that in the control group after intervention (P＜0.05). The awareness rate of disease-related knowledge in the research group was higher than that in the control group (P＜0.05). The incidence of hypoglycemia in the research group was lower than that in the control group (P＜0.05). The medication compliance, moderate exercise and blood glucose control in the research group were better than those in the control group after intervention, the differences were statistically significant (P＜0.05).Conclusion Orem self-care mode intervention in senile patients with diabetes can increase self-care ability and cognitive ability of disease-related knowledge, reduce the incidence of hypoglycemia, encourage patients to choose healthier behaviors and promote rehabilitation, which is an effective nursing mode and worthy of clinical promotion.
2020 Vol. 27 (29): 234-236 [Abstract] ( 19 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
237 Effect of integrated nursing mode of medical and nursing on the rehabilitation of patients after laparoscopic cholecystectomy
ZHANG Xu-yan
Objective To explore the effect of integrated nursing mode on the rehabilitation of patients after laparoscopic cholecystectomy (LC). Methods From January 2018 to December 2019, 150 patients with LC in our hospital were selected and divided into two groups according to the random number table method, 75 cases in each group. The control group was given routine nursing, and the observation group was given integrated nursing mode. The postoperative recovery, pain, complication rate, patients′ cooperation degree and nursing satisfaction were compared between the two groups. Results The exhaust time, defecation time, bowel sound recovery time and hospitalization time in the observation group were (23.53 ±3.52), (40.51±4.57) , (8.98±1.30) h and (5.86±1.52) d, which were shorter than those in the control group of (27.54±4.18), (45.74±4.29), (10.56±1.17) h, (7.11±1.34) d, with statistical differences (P＜0.05).There was no difference in pain score between the two groups on the first day after operation (P＞0.05). The pain score of the observation group was (2.63±0.57) points, lower than that of the control group of (3.44±0.49) points, the difference was statistically significant (P＜0.05). The total complication rate in the observation group was 2.67%, which was lower than 12.00% in the control group, the degree of coordination was 93.33% and the total satisfaction with nursing was 94.67% in the observation group, which were higher than 82.67% and 81.33% in the control group, the differences were statistically significant (P＜0.05). Conclusion The integrated nursing mode of medical and nursing can speed up the rehabilitation process of patients after LC shorten the recovery time of getting out of bed and exhausting after operation, reduce the postoperative pain of patients, prevent the occurrence of complications, improve the cooperation degree of diagnosis and treatment and nursing satisfaction of patients, which is worth popularizing and applying.
2020 Vol. 27 (29): 237-240 [Abstract] ( 19 ) HTML (36 KB)  PDF  (0 KB)  ( 12 )
241 Application of personalized nursing in the perioperative period of elderly patients with inguinal hernia without tension hernia repair
ZHENG Wei
Objective To explore the application of personalized nursing in the perioperative period of elderly patients with inguinal hernia without tension hernia repair. Methods A total of 73 elderly patients with inguinal hernia who were treated in our hospital from April 2017 to August 2019 were selected as the subjects. All patients underwent tension-free hernia repair. They were divided into two groups according to the coin flip method. The reference group (n=36, patients used routine nursing care) and the nursing group (n=37, patients used individualized care). Postoperative recovery and improvement in quality of life between two groups were compared. Results The time of getting out of bed,recovery of gastrointestinal function, and length of stay in the nursing group were shorter than those in the reference group, and the differences were statistically significant (P＜0.05). Before intervention, there was no significant difference in the quality of life scores between the two groups (P＞0.05). After intervention, the quality of life scores in the nursing group were higher than that in the reference group, the quality of life score of two groups were higher than before intervention, and the differences were statistically significant (P＜0.05). Conclusion Compared with conventional nursing, the clinical advantages of individualized nursing applied to tension-free hernia repair in elderly patients with inguinal hernia are more obvious. It can significantly shorten the recovery time after surgery, discharge as soon as possible, and improve the quality of life of patients. It is recommended for application.
2020 Vol. 27 (29): 241-243 [Abstract] ( 18 ) HTML (31 KB)  PDF  (0 KB)  ( 9 )
244 Application effect of targeted nursing on the perioperative period of Bard minimally invasive mastectomy for breast cancer patients
HUANG Li
Objective To explore the application effect of targeted nursing in the perioperative period of Bard minimally invasive breast circumcision treated breast tumor. Methods From January to December 2019, 80 patients with breast cancer who underwent Bard′s minimally invasive mastectomy in our hospital were selected as objects of study, according to random number table method, they were divided into control group and observation group, 40 cases in each group. The control group received routine perioperative nursing, and the observation group received targeted nursing on this basis. The changes of perioperative emotional state score, postoperative hospital stay, complications and total nursing satisfaction were compared between the two groups. Results The scores of self-rating anxiety scale (SAS) and selfrating depression scale (SDS) in the observation group were lower than those in the control group before and after operation, and the hospitalization time was shorter than that in the control group, the differences were statistically significant (P＜0.05). The total incidence of complications in the observation group was lower than that in the control group,the total satisfaction of the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05). Conclusion Targeted nursing can improve the perioperative emotional state of patients with breast cancer, promote the postoperative recovery and reduce the risk of complications.
2020 Vol. 27 (29): 244-246 [Abstract] ( 23 ) HTML (32 KB)  PDF  (0 KB)  ( 8 )
247 Effect of kangaroo nursing on breastfeeding
AO Yu-min HU Li-hua LI Shuang-shuang LUO Yan-mei
Objective To explore the effect of kangaroo nursing on breastfeeding. Methods A total of 98 parturients admitted to our hospital from June 2018 to January 2020 were selected as the research objects. According to the random number table method, they were divided into the control group (49 cases) and the observation group (49 cases).The control group adopted conventional nursing method, the observation group adopted kangaroo nursing method. The postpartum breastfeeding, postpartum hemorrhage and uterine involution of the two groups were compared. Results The breast-feeding score of the observation group was higher than that of the control group, the difference was statistically significant (P＜0.05). At 42 days postpartum, the maternal feeding method in the observation group was better than that in the control group, the difference was statistically significant (P＜0.05). The incidence of one finger under the umbilical cord of the observation group was lower than that of the control group, and the incidence of two fingers under the umbilical cord was higher than that of the control group, the differences were statistically significant (P＜0.05). At 42 days postpartum, the proportion of uterus returned to normal size in the observation group was higher than that in the control group, the difference was statistically significant (P＜0.05). There were no significant differences between the two groups in postpartum hemorrhage≤1 h and postpartum hemorrhage ＞1-2 h (P＞0.05); the postpartum hemorrhage ＞2-24 h in the observation group was less than that of the control group, the difference was statistically significant (P＜0.05). Conclusion Kangaroo nursing has a positive effect on breastfeeding, which can improve the score of breastfeeding, improve the rate of exclusive breastfeeding, promote the recovery of uterus, reduce the incidence of postpartum hemorrhage, and has a high application value.
2020 Vol. 27 (29): 247-250 [Abstract] ( 19 ) HTML (32 KB)  PDF  (0 KB)  ( 9 )
251 Application effect of comprehensive nursing in gallstone patients
YU Jing
Objective To explore the influence of comprehensive nursing on the treatment effect and nursing satisfaction of patients with gallstones. Methods A total of 140 patients with gallstones admitted to our hospital from June 2018 to June 2019 were selected as the research objects, according to the random number table method, patients were divided into observation group and control group, 70 cases in each group. The control group was given routine nursing，the observation group was given comprehensive nursing intervention on the basis of the control group. The operation time, intraoperative blood loss, hospitalization time, postoperative exhaust time, patient′s emotional state changes, total nursing satisfaction, complications were compared between two groups. Results The operation time，hospitalization time and postoperative exhaust time of the observation group were shorter than those of the control group, and the intraoperative blood loss was less than that of the control group, the differences were statistically significant (P＜0.05); after intervention, the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05); the overall satisfaction of nursing services in the observation group was higher than that in the control group and complications total incidence was lower than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion The application effect of comprehensive nursing intervention for patients with gallstones is significant.
2020 Vol. 27 (29): 251-252 [Abstract] ( 20 ) HTML (32 KB)  PDF  (0 KB)  ( 11 )
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