24例家族性良性慢性天疱疮患者临床资料分析

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Abstract Objective To investigate the clinical characteristics, inducing factors and treatment of Hailey-Hailey disease (HHD). Methods Clinical data of 24 patients with HHD admitted to department of dermatology in our hospital from January 1999 to December 2018 were retrospectively analyzed. Results Among the 24 patients, the male/female ratio was 3.8∶1. Patients age ranged from 31 to 70 years old, mean age was (49.54±9.02) years old. The onset age ranged from 13 to 47 years old, mean onset age was (31.04±9.49) years old. Groins and armpits were the most involved locations of rash. Hot and humid climate in summer was the most common triggers of HHD and followed by drinking,spicy foods and friction. The therapy of Compound Glycyrrhizin Injection, Minocycline Capsules, Glucosidorum Tripterygll Totorum combined with local symptomatic treatment was effective to HHD. Conclusion HHD is long-lasting, difficult to cure andprone to recurrence. Traditional treatment with systemic and topical medications can control symptoms, but it is difficult to prevent recurrence. Surgical treatment, laser treatment, and botulinum toxin injection play a certain role in preventing recurrence.

Key words： Pemphigus Familial Chronic Clinical analysis Treatment

Received: 20 March 2020

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