玻璃体腔注射雷珠单抗联合视网膜光凝治疗糖尿病性黄斑水肿的效果

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Abstract Objective To explore the effect of intravitreal injection of Ranibizumab combined with retinal photocoagulation in the treatment of diabetic macular edema. Methods A retrospective analysis was conducted on the clinical data of 90 patients (91 eyes) with diabetic macular edema diagnosed in our hospital from January 2017 to January 2018. According to different treatment methods, they were divided into the treatment group (45 cases, 46 eyes) and the control group (45 cases, 45 eyes). The patients in the treatment group were given intravitreal injection of Ranibizumab combined with macular grid photocoagulation or focal photocoagulation, and the patients in the control group were given Ranibizumab single treatment. The best corrected visual acuity at 1 month and 3 months after treatment, the retinal thickness at macula central fovea before and after treatment, the macular edema and leakage, and the occurrence of adverse reactions were compared. Results The best corrected visual acuity at 3 months after treatment in the treatment group was better than that in the control group, with statistically significant difference (P＜0.05). There was no statistically significant difference in the best corrected visual acuity at 1 month after treatment between the two groups (P＞0.05). The retinal thickness at macula central fovea in the two groups at 1 month and 3 months after treatment was lower than that before treatment, with statistically significant difference (P＜0.05). The retinal thickness at macula central fovea in the treatment group at 1 month and 3 months after treatment was lower than that in the control group, with statistically significant difference (P＜0.05). The retinal thickness at macula central fovea in the control group at 3 months after treatment was higher than that in the control group at 1 month after treatment, with statistically significant difference (P＜0.05). The fundus fluorescein angiography was repeated at 3 months after treatment, and the proportion of leakage eyes in the treatment was lower than that in the control group, with statistically significant difference (P＜0.05). During the treatment follow-up, there were no adverse reactions in eyes or whole body in the two groups. Conclusion In comparison with intravitreal injection of Ranibizumab single treatment, intravitreal injection of Ranibizumab combined with retinal photocoagulation has better effect in improving visual acuity and restoring retinal function in patients with diabetic macular edema, with better safety.

Key words： Diabetic macular edema Ranibizumab Intravitreal injection Retinal photocoagulation

Received: 20 March 2020

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