RANKL基因多态性与动脉粥样硬化性脑梗死发病的相关性

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Abstract Objective To explore the correlation between rs9533156 polymorphism of receptor activator for nuclear factor-κB ligand (RANKL) gene and the pathogenesis of atherosclerotic cerebral infarction. Methods From March 2018 to July 2018, a total of 213 patients diagnosed as atherosclerotic cerebral infarction in neurology department of Shengjing Hospital Affiliated to China Medical University were selected as the case group, and 197 healthy people in the physical examination center at the same time as the control group. Rs9533156 locus of RANKL gene was genotyped by improved multiple ligase reaction. Logistic regression analysis was used to investigate the correlation between RANKL gene polymorphism and the incidence of atherosclerotic cerebral infarction. Results There was no statistically significant difference in the genotype distribution of rs9533156 between the two groups (P>0.05); the comparison of the frequency of each allele was not statistically significant (P>0.05). Conclusions There is no significant correlation between the rs9533156 polymorphism of RANKL gene and the susceptibility of atherosclerotic cerebral infarction.

Key words： Gene polymorphism Atherosclerotic cerebral infarction Receptor activator for nuclear factor-κB ligand;rs9533156 locus

Received: 29 April 2020

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