经靶动脉超选灌注碳酸氢钠联合罂粟碱对实体恶性肿瘤化疗栓塞术增效的临床观察

Abstract
Figure/Table
References (17)
Related Citation (10)

Download: PDF (0 KB) HTML (37 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the application effect of superselective infusion of Sodium Bicarbonate combined with Papaverine through the target artery on chemoembolization of solid malignant tumor. Methods A total of 60 patients with solid malignant tumor treated by chemoembolization in our hospital from January 2018 to March 2019 were selected as the research subjects and divided into the study group and the control group according to the random number table method, with 30 cases in each group. The study group was treated by chemoembolization+target artery superselective infusion of Sodium Bicarbonate combined with Papaverine, while the control group was treated by chemoembolization alone. The therapeutic effect, side effects of the two groups were compared. The survival and Karnofsky(KPS) scores after 6 and 12 months of follow-up of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05).There were no statistically significant differences in the incidence of leucopenia, gastrointestinal reaction, pain reaction and fever between the two groups (P＞0.05). There were no statistically significant differences in survival rate and KPS scores between the two groups after 6 and 12 months of follow-up (P＞0.05). The survival rate of the observation group after 12 months of follow-up was higher than that of the control group, and the KPS scores of the observation group after 6 and 12 months of follow-up were higher than those of the control group, and the differences were statistically significant (P＜0.05). Conclusion Superselective infusion of Sodium Bicarbonate combined with Papaverine through the target artery can improve the therapeutic effect of chemoembolization for solid malignant tumors, improve the long-term survival rate and KPS score, and will not increase the side effects, which is worthy of clinical recommendation.

Key words： Solid malignant tumor Sodium Bicarbonate Papaverine Chemoembolization

Received: 07 April 2020

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

https://www.dangdaiyiyao.com/EN/ OR https://www.dangdaiyiyao.com/EN/Y2020/V27/I29/87

[1]	霍亮.化疗栓塞术联合恩度对中晚期肝癌患者实体肿瘤、KPS 评分及VEGF 水平的影响[J].河南医学研究，2016，25（1）：64-65.
[2]	朱泽民，谢智钦，赵志坚，等.阿帕替尼联合经导管肝动脉化疗栓塞治疗中晚期肝癌疗效及安全性的Meta 分析[J].中国普通外科杂志，2019，28（7）：798-808.
[3]	李骏，宫希军，徐璐，等.靶向肿瘤内高乳酸环境经肝动脉化疗栓塞术治疗肝细胞癌的临床观察[J].局解手术学杂志，2018，27（12）：888-891.
[7]	董坚.实体肿瘤靶向药物疗效评价标准的现状和展望[J].中国肿瘤生物治疗杂志，2015，22（4）：413-419.
[8]	王慧明，杜向东.经靶动脉灌注碳酸氢钠减轻肝癌介入治疗的不良反应[J].兵团医学，2017，15（3）：48-49.
[9]	张岩，乔录新，曾静，等.碳酸氢钠诱导肝癌细胞凋亡机制研究[J].中国医药导报，2018，15（23）：9-12，182.
[10]	韩其正，曹望凯，王永明.灌注化疗联合碳酸氢钠与单纯支气管动脉灌注化疗治疗非小细胞肺癌的疗效分析[J].医学临床研究，2018，35（12）：2467-2468.
[4]	Banerjee D，Bose S.Comparative effects of controlled release of sodium bicarbonate and doxorubicin on osteoblast and osteosarcoma cell viability[J].Mater Today Chem，2019，6（12）：200-208.
[5]	Gunn AJ，Sheth RA，Luber B，et al.Predicting Outcomes After Chemo-Embolization in Patients with Advanced-Stage Hepatocellular Carcinoma：An Evaluation of Different Radiologic Response Criteria[J].Cardiovasc Intervent Radiol，2017，40（1）：61-68.
[6]	Reali A，Allis S，Girardi A，et al.Is Karnofsky Performance Status Correlate with Better Overall Survival in Palliative Conformal Whole Brain Radiotherapy? Our Experience[J].Indian J Palliat Care，2015，21（3）：311-316.
[11]	Zhang H.Will cancer cells be defeated by sodium bicarbonate?[J].Sci China Life Sci，2017，60（3）：326-328.
[12]	冯德日，李林森，金明林，等.四氢罂粟碱类似物的合成及活性评价[J].科学技术与工程，2014，14（26）：1-4，12.
[13]	Fuska J，Fusková A，Proksa B.New cytotoxic and antitumor agents.VII.Derivatives of 1-benzylidenisoindolin-3-one and 5，6-dihydro-8H-isoquinolo （2,3-a）phthalasin-5-one[J].Neoplasma.1985，32（4）：407-414.
[14]	杨秀伟，冉福香，王瑞卿，等.44 种生物碱类化合物对人胃癌细胞株BGC 和人肝癌细胞株BEL-7402 细胞增殖抑制活性的筛选[J].中国现代中药，2007，9（2）：6-9.
[15]	高慧，贺苗，王晓琴，等.注射用盐酸罂粟碱联合注射用降纤酶对老年晚期子宫内膜癌并急性次大面积肺栓塞的影响[J].实用心脑肺血管病杂志，2019，27（3）：83-87.
[16]	范平生，谢钊，吴志丽，等.经靶动脉灌注碳酸氢钠提高部分抗肿瘤药物疗效[J].临床肿瘤学杂志，2005，10（1）：52-54.
[17]	Afzali M，Ghaeli P，Khanavi M，et al.Non-addictive opium alkaloids selectively induce apoptosis in cancer cells compared to normal cells[J].Daru，2015，23（1）：16.