泛素蛋白酶体途径在癫痫发病机制中的作用研究进展

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Abstract Epilepsy is a common chronic nervous system disease, which is characterized by sudden, recurrent seizures and temporary central nervous system dysfunction caused by excessive discharge of brain neurons. Recent studies have shown that the occurrence of epilepsy is closely related to ion channels, neurotransmitters and synaptic connections. Ubiquitin-proteasome pathway is an important protein degradation pathway in vivo, which regulates many cellular physiological processes. Many substrates modified by ubiquitination are ion channel that affect central nervous excitability,such as voltage-gated ion channels including sodium channels and potassium channels as well as ligand-gated ion channels including AMPA receptor and NMDA receptor. Ubiquitination affects neuronal excitability by regulating the expression level of these channel proteins, which is closely related to the pathogenesis of epilepsy.

Key words： Ubiquitination Ubiquitin E3 ligase Epilepsy Ion channel

Received: 09 June 2020

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