穴位贴敷止呕方联合托烷司琼治疗化疗后恶心呕吐患者的临床效果

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Abstract Objective To explore the clinical effect of acupoint application of Zhiou Prescription combined with Tropisetron in the treatment of patients with nausea and vomiting after chemotherapy. Methods A total of 48 patients who underwent XELOX chemotherapy in the Department of Oncology of Changsha Hospital of Traditional Chinese Medicine (Changsha Eighth Hospital) from August 2017 to May 2019 were selected as subjects. By the random number table method, patients were divided into the treatment group and the control group, 24 cases in each group. All patients were treated with conventional treatment. In the control group, Tropisetron on the basis of conventional treatment was added, and in the treatment group, acupoint application of Zhiou Prescription on the basis of the control group was added. The clinical efficacy, improvement in nausea and vomiting, degree of gastrointestinal reaction, quality of life and safety in the two groups were observed. Results After treatment, the total clinical effective rate in the treatment group(91.67%) was higher than that in the control group (70.83%), and the difference was statistically significant (P＜0.05).Before treatment, there were no statistically significant differences in the scores of nausea and vomiting and QLQ-C30 on the quality of life measurement scale between the two groups (P＞0.05). After treatment, the nausea and vomiting scores of the two groups were lower than those before treatment, and the nausea and vomiting scores in the treatment group were lower than those in the control group, the differences were statistically significant (P＜0.05). After treatment,the QLQ-C30 scores of the two groups were higher than those before treatment, and the QLQ-C30 score of the treatment group was higher than that of the control group, the differences were statistically significant (P＜0.05). After treatment, the total effective rate of the gastrointestinal reaction (87.50%) in the treatment group was higher than that in the control group (62.50%), and the difference was statistically significant (P＜0.05). The total incidence of adverse reactions was 8.33% in the treatment group, which was not significantly different from that in the control group accounting for 16.67% (P＞0.05). Conclusion Acupoint application of Zhiou Prescription combined with Tropisetron can effectively relieve the nausea and vomiting of patients after XELOX chemotherapy, improve their quality of life, and obtain a remarkable clinical effect with high safety, which provides a scientific basis for further promotion and application.

Key words： Acupoint application of Zhiou Prescription Tropisetron Chemotherapy Nausea and vomiting

Received: 08 May 2020

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