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Quick Search     Adv Search 2021 Vol. 28, No. 19 Published: 2021-07-08   4 Cross-sectional investigation study on the treatment status of patients with chronic myeloid leukemia in Shenzhen WANG Dan-yu JIN Meng-di CUI Hai-yan WANG Xin Objective To investigate the treatment perplexity and demand of patients with chronic myeloid leukemia(CML) in Shenzhen, and to analyze its influencing factors. Methods This study was a cross-sectional investigation.From August 9 to 30, 2019, CML patients receiving tyrosine kinase inhibitor (TKI) in Shenzhen were investigated by questionnaire and the data were analyzed. Results A total of 187 valid questionnaires were collected, of which 105(56.1%)were male,with a median age of 37(18-70)years old.The non-hematological adverse reactions that had the greatest impact were: fatigue in 55 cases (29.4%), edema in 54 cases (28.9%), and itchy skin in 33 cases (17.6%). Hematological adverse reactions were anemia in 81 cases (43.3%) and neutropenia in 39 cases (20.9%). The troubles caused by TKI treatment were the financial burden caused by long-term medication (73.0%), adverse reactions caused by drugs(65.0%), and psychological stress caused by illness (63.0%). In terms of the needs of patients′ churches: more than half of the respondents hoped to carry out the survey every 6 and 12 months, and the most desirable contents were the latest progress in CML, the management of adverse reactions and the sharing of CML patients′ own management experience.Conclusion The patient-reported outcome deviates from the clinician′s focus. By focusing on the treatment difficulties and needs of CML patients, preoperative counseling can be conducted more effectively, patient management can be promoted, patient experience can be improved, and the overall outcome of treatment can be improved. 2021 Vol. 28 (19): 4-7 [Abstract] ( 50 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 8 Analysis of serum metabolism of qi and yin deficiency syndrome in the compensated stage of chronic renal failure based on 1H-NMR technology ZHANG Min-ji1 GAO Ji-ning2▲ ZHANG Xue-qi3 Objective To analyze the serum metabolism of qi and yin deficiency syndrome in the compensated stage of chronic renal failure based on 1H-NMR technology. Methods From January to November 2019, 15 voluntary patients with qi and yin deficiency syndrome in the compensated stage of chronic renal failure admitted to the Third Department of Nephrology, Shanxi Hospital of Integrated Traditional and Western Medicine were selected as the disease group, and 15 healthy patients′ family members and volunteers were selected as the control group. Fasting venous blood was collected and prepared for sample processing. 1H-NMR technology combined with principal component analysis (PCA),orthogonal partial least squares discriminant analysis (OPLS-DA) and other diversified analytical methods were used to find endogenous compounds and compare metabolite differences between groups. Results In the disease group, the contents of seven metabolic differences including arginine, proline and lipid were higher than those in the control group,and the contents of two kinds of choline and phosphatidylcholine were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion It is initially found that there is a specific metabolic profile in the syndrome of deficiency of both qi and yin in the compensatory phase of chronic renal failure. The metabolic disorder of qi and yin deficiency syndrome in the compensatory phase of CRF may mainly involve amino acid and lipid metabolism. Metabonomics technology can provide a more comprehensive reference for the modern research and clinical practice of traditional Chinese medicine kidney disease,and help realize the ultra-early diagnosis and treatment of chronic renal failure. 2021 Vol. 28 (19): 8-11 [Abstract] ( 41 ) HTML (36 KB)  PDF  (0 KB)  ( 9 ) 12 Effect of Doxorubicin on the expression of PDCD4 and PTEN proteins in human breast cancer cells YANG Yong WU Mu-yu JIANG Shan Objective To investigate the effect of Doxorubicin on the expression of programmed apoptosis factor 4 (PDCD4) and phosphatase and tension protein homologue (PTEN) in human breast cancer cells MCF-7 and the regulation of microRNA (miR)-21. Methods In the first step, MCF-7 cell lines were treated with Doxorubicin at concentrations of 2.5, 5 and 10 μmol/L respectively. The anti-proliferative effect of Doxorubicin on MCF-7 cells was assessed by CCK-8 method. The expression of miR-21 was detected by real-time fluorescence quantitative PCR. Western Blot was used to evaluate the expression of PDCD4 and PTEN proteins. In the second step, MCF-7 cells were transfected by miR-21 and non-transfected cells were used as the control group. The expressions of PDCD4 and PTEN were detected by Western Blot. Results The expressions of miR-21 and cell survival rate in the 5 μmol/L and 10 μmol/L groups were lower than those in the DMSO group, and the differences were statistically significant (P＜0.05). The expressions of miR-21 and cell survival rate in the 10 μmol/L group were lower than those in the 5 μmol/L group, and the differences were statistically significant (P＜0.05). With the increase of Doxorubicin concentration, there was a significant increase in the expression of PDCD4 and PTEN proteins. After being transfected with miR-21, the expression levels of PDCD4 and PTEN proteins in the MCF-7 cells were lower than those in the control group. Conclusion In breast cancer MCF-7 cells, miR-21 regulates the expression of target genes PDCD4 and PTEN, thereby inhibiting tumor cell proliferation. 2021 Vol. 28 (19): 12-15 [Abstract] ( 43 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 16 Clinical effect of Dachengqi Decoction in the treatment of mild acute pancreatitis and its effect on intestinal mucosal barrier WANG Hong-fang1 SHEN Jian-gang2▲ LI Jun-da2 YE Shi-cai3 HUANG Jin-wen2 QIU Jia-hua2 HUANG Min2 YANG Chi2 Objective To investigate the clinical effect of Dachengqi Decoction in the treatment of mild acute pancreatitis (MAP) and its effect on intestinal mucosal barrier. Methods A total of 60 MAP patients admitted to Shenzhen Luohu District People′s Hospital and Longhua District People′s Hospital from January 2017 to December 2018 were selected as the research subjects and divided into control group (30 cases) and experimental group (30 cases) according to random number table method. The control group was treated with conventional Western medicine and the experimental group was treated with Dachengqi Decoction on the basis of the control group. The clinical treatment effect, clinical indicators, intestinal mucosal barrier injury indexes, inflammatory factors and the incidence of adverse reactions were compared between the two groups. Results The total effective rate of the experimental group was higher than that of the control group, the difference was statistically significant (P＜0.05). The disappearance time of abdominal pain and abdominal distension, the recovery time of intestinal sounds, the first defecation time and the hospital stay in the experimental group were all shorter than those in the control group, the differences were statistically significant (P＜0.05). Before treatment, there were no significant differences in intestinal mucosal barrier injury indexes between the two groups(P＞0.05). After 3 and 5 days of treatment, the serum levels of intestinal fatty acid binding protein and D-lactic acid in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05).Before treatment, there were no significant differences in inflammatory cytokines between two groups (P＞0.05). After 3 and 5 days of treatment, the levels of blood amylase, C-reactive protein and interleukin-6 in the experimental group were all lower than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion The addition of Dachengqi Decoction on the basis of the conventional treatment of MAP can significantly improve the curative effect, repair the intestinal mucosal barrier and inhibit inflammatory factors. 2021 Vol. 28 (19): 16-19转24 [Abstract] ( 41 ) HTML (40 KB)  PDF  (0 KB)  ( 7 ) 20 Clinical effect of pretreatment of Ethinyl Estradiol and Cyproterone Tablets in polycystic ovary syndrome patients with frozen-thawed embryo transfer cycles combined with Letrozole in intimal preparation LIU Qian-ru CHEN Meng-xun HUANG Qi-yun Objective To investigate the effect of Ethinyl Estradiol and Cyproterone Tablets (hereinafter referred to as"Diane-35") pretreatment combined with Letrozole in endometrial preparation of frozen-thawed embryo transfer (FET)cycles in patients with polycystic ovary syndrome (PCOS). Methods A total of 184 patients with PCOS who underwent FET from March 2015 to July 2018 in Foshan Women and Child Hospital were selected as the research objects, and they were divided into group A (93 cases) and group B (91 cases) according to the different endometrial preparation schemes. Both groups were given Diane-35 pretreatment, group A was pretreated with Letrozole to prepare the inner membrane, group B was treated with Diane-35 for pretreatment and hormone replacement to prepare the inner membrane. The results of embryo transfer, the success rate of embryo transfer and the clinical pregnancy rate of the two groups were compared. Results There was no significant difference in endometrial preparation days between the two groups (P＞0.05); the endometrial thickness of group A was greater than that of group B, and the cycle cancellation rate of group A was lower than that of group B, with statistical significances (P＜0.05). The clinical pregnancy rate of group A was higher than that of group B, and the difference was statistically significant (P＜0.05). The early abortion rate after pregnancy in group A was lower than that in group B,and the difference was statistically significant (P＜0.05).There was no statistical difference in ectopic pregnancy rate between the two groups (P＞0.05). The endometrial thickness and estradiol level in pregnant women were higher than those in non-pregnant women, and the differences were statistically significant (P＜0.05). There were no significant differences in the indexes between the non-pregnant groups. Conclusion Diane-35 pretreatment combined with Letrozole has a significant effect on the FET in patients with PCOS, which can reduce the level of androgen in patients and increase the clinical pregnancy rate. 2021 Vol. 28 (19): 20-24 [Abstract] ( 40 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 25 Effect comparison of laparoscopic total extraperitoneal hernia repair, laparoscopic preperitoneal hernia repair and open tension-free hernia repair in the treatment of inguinal hernia TU Chun-ming DONG Qing-shen LIU Jian-lei Objective To explore the effect of laparoscopic total extraperitoneal hernia repair (TEP), laparoscopic preperitoneal hernia repair (TAPP) and open tension-free hernia repair for inguinal hernia, to analyze the effect of different surgical methods on recurrence, C-reactive protein (CRP) and interleukin-6 (IL-6) levels in peripheral blood of patients. Methods A retrospective analysis was conducted on 159 cases of inguinal hernia patients admitted to the Second Department of General Surgery, Beijing Renhe Hospital from February 2019 to June 2020, and they were divided into three groups according to surgical methods. Fifty-three patients in the observation group 1 received TEP, 53 patients in the observation group 2 received TAPP, and 53 patients in the control group received open tension-free hernia repair. The amount of intraoperative blood loss, operation time, postoperative activity time out of bed and hospitalization time of the three groups were compared. Serum indexes and visual analogue scale (VAS) scores of three groups were compared. The total incidence and recurrence rate of complications were compared among the three groups. Results There were no significant differences in operation time, postoperative activity time and IL-6 between the observation group 1 and the observation group 2 (P＞0.05). The amount of intraoperative blood loss in observation group 1 was less than that in observation group 2, and the length of hospital stay was shorter than that in observation group 2, with statistical significances (P＜0.05). The amount of intraoperative blood loss in observation group 1 and observation group 2 was less than that in control group, and the duration of operation, postoperative activity time out of bed and hospital stay were shorter than those in control group, with statistical significances (P＜0.05). The CRP and VAS score at 48 h after operation in the observation group 1 were lower than those in the observation group 2, the differences were statistically significant (P＜0.05). IL-6 and CRP at 48 h after operation and VAS scores at 24 and 48 h after surgery in observation group 1 and observation group 2 were lower than those in control group, the differences were statistically significant (P＜0.05). The total incidence and recurrence rate of postoperative complications in observation group 1 were lower than those in control group, and the difference was statistically significant (P＜0.017). The total incidence and recurrence rate of postoperative complications in the observation group 2 were lower than those in the control group, but after adjustment, the differences were not statistically significant (P＞0.017). Conclusion In the treatment of inguinal hernia, the use of TEP and TAPP can reduce the recurrence rate and reduce the inflammation. Compared with TAPP,the safety of TEP is more significant. 2021 Vol. 28 (19): 25-29 [Abstract] ( 40 ) HTML (38 KB)  PDF  (0 KB)  ( 5 ) 30 Correlation study between the burden of caregivers of burn patients and the quality of life Objective To explore the correlation between the burden of caregivers of burn patients and the quality of life. Methods A self-designed general survey form, a short form 36 health survey (SF-36), and Zarit burden interview(ZBI) were applied to investigate the burden and quality of life of 220 primary caregivers of 220 burn patients treated in the Department of Burns and Plastic Surgery, General Hospital of Ningxia Medical University. Results Six invalid questionnaires were eliminated, and 214 main caregivers of burn patients were finally recruited as the subjects of study.The total score of care burden for the caregivers of 214 burn patients was(34.22±14.68)points;the personal burden score was (20.27±7.67) points, and the responsibility burden score was (7.29±5.22) points. The scores of physical function and social function of the caregivers of burn patients were higher than those of the national norm, and the scores of general health, energy, emotional function and mental health were lower than those of the national norm (P＜0.05). Pearson correlation analysis results of the relationship between caregivers burden and quality of life of burn patients showed that the burden of responsibility, personal burden and total burden score of the caregivers of burn patients were negatively correlated with their energy,emotional function and mental health(P＜0.05).Conclusion The burden of burn patients′caregivers is negatively correlated with their quality of life. The caregivers of burn patients have a burden of care and their quality of life is impaired. Relevant professionals can pay attention to the burden of caregivers, provide necessary support, and improve caregivers′ quality of life. 2021 Vol. 28 (19): 30-34 [Abstract] ( 49 ) HTML (41 KB)  PDF  (0 KB)  ( 6 ) 35 Research progress of P300 in cognitive impairment in type 2 diabetes mellitus CHEN Min-rui1 LUO Wei-liang2▲ Patients with type 2 diabetes mellitus can cause cognitive impairment through a variety of mechanisms, and their risk of developing dementia is twice as high as people without diabetes mellitus. The prevalence of type 2 diabetes mellitus is gradually increasing. Early diagnosis of cognitive impairment and drug intervention are of great value to delay or even reverse the progression of the disease. As an objective neural electrophysiological index, event-related potential P300 has the advantages of noninvasive, short test time, and no need for verbal, literal and movement cooperation of subjects. Compared with normal people, the latency of P300 in patients with type 2 diabetes mellitus is longer and the amplitude is lower, which can be used to identify and evaluate the impairment of cognitive function in the early stage of clinical practice. It is of great significance to prevent the occurrence of dementia, improve the prognosis and long-term quality of life of patients. Therefore, this article summaries the origin, clinical application and research prospect of P300 test in the assessment of cognitive impairment in patients with type 2 diabetes mellitus. 2021 Vol. 28 (19): 35-38 [Abstract] ( 47 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 39 Clinical research progress of sodium-glucose co-transporter inhibitor 2 in the treatment of diabetic nephropathy LIU Fei-yan Diabetic nephropathy is a microvascular complication of diabetes. With the development of the disease,there may be end-stage renal disease, which poses a great threat to the life safety of patients. In clinical practice, the clinical treatment of diabetic nephropathy is difficult, so the prevention and treatment of this disease has become the focus of clinical attention. In recent years, the emergence of a new type of glucose-lowering drug, sodium-glucose cotransporter inhibitor 2 (SGLT-2i) has brought a new opportunity for the prevention and treatment of diabetic nephropathy. SGLT-2i can not only reduce the blood glucose level of patients, but also effectively protect their kidney function.Therefore, this article will further elaborate the possible mechanism of SGLT-2i in diabetic nephropathy. 2021 Vol. 28 (19): 39-42 [Abstract] ( 50 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 43 Application effect of hydrocolloid dressing in prevention and treatment of scar by pressure therapy after extremities burn ZENG Qun-ying LIU Hua-zhi▲ LAI Sheng-fei HE Gui-hua GUO Xiang-lan DONG Li CHEN Dan Objective To observe the safety and feasibility of hydrocolloid dressing+pressure therapy in the prevention and treatment of scar after extremities burn. Methods A total of 50 patients with deep Ⅱdegree burn wounds in the First Affiliated Hospital of Gannan Medical University from May 2017 to December 2018 were selected as the research objects, and they were divided into control group and treatment group by the random number table method, with 25 cases in each group. The control group was treated with ordinary gauze dressing+pressure therapy, while the treatment group was treated with hydrocolloid dressing+pressure therapy. The pain degree of dressing change, residual wound healing time, dressing change times and Vancouver scar scale score between the two groups were compared. Results The pain degree of dressing change in the treatment group was lower than that in the control group, the difference was statistically significant (P＜0.05). The residual wound healing time in the treatment group was shorter than that in the control group, and the dressing change times was less than that in the control group, the differences were statistically significant (P＜0.05). The scores of Vancouver scar scale in the treatment group at 4 and 12 weeks after treatment were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Hydrocolloid dressing applied to pressure therapy after extremities burn can accelerate the residual wound healing, improve the comfort of patients, and improve the compliance of patients with pressure therapy, the efficacy is positive. 2021 Vol. 28 (19): 43-45转52 [Abstract] ( 47 ) HTML (33 KB)  PDF  (0 KB)  ( 9 ) 46 Diagnostic value of thinprep cytologic test, human papillomavirus combined with squamous cell carcinoma antigen in cervical cancer and precancerous lesions TAN Yu-qing1 LIN Su-yu2 LI Xiao-li1 Objective To investigate the diagnostic value of thinprep cytologic test (TCT), human papillomavirus (HPV)combined with squamous cell carcinoma antigen (SCCA) in cervical cancer and precancerous lesions. Methods A total of 65 patients with cervical cancer and 155 patients with cervical intraepithelial neoplasia grade Ⅲwho were admitted to Jiangmen Maternity and Child Health Hospital from November 2019 to November 2020 were retrospectively selected as the cervical cancer group and precancerous lesions group, respectively. Both groups were tested for TCT and HPVDNA, and fasting venous blood was drawn to determine their serum SCCA levels by chemiluminescence method. The detection rates of TCT, HPV-DNA, serum SCCA three tests and combined tests in the two groups were compared, the sensitivity, specificity and accuracy of the three test methods alone and in combination in the diagnosis of cervical cancer were analyzed and compared. Results The detection rate of TCT, HPV-DNA, and serum SCCA in combination in the cervical cancer group was higher than that of individual examination and pairwise combined examinations, and the difference was statistically significant (P＜0.05). There was no significant difference in the detection rate of three kinds of TCT, HPV-DNA and serum SCCA examination, alone and pairwise combined examination in the precancerous lesion group (P＞0.05). The sensitivity, specificity and accuracy of TCT, HPV-DNA and serum SCCA were 100.00%,77.42% and 84.09% respectively, and the sensitivity and accuracy of diagnosis were higher than those of single examination and pairwise combined examination. Conclusion The combined application of TCT, HPV and SCCA examination can improve the detection rate of cervical cancer and improve the accuracy of diagnosis of cervical cancer and precancerous lesions, which is worthy of clinical application. 2021 Vol. 28 (19): 46-48转57 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 49 Study on the preventive effect of interference electric therapy on muscular atrophy in patients with subconscious disorder in intensive care HUANG Min-dong YUAN Xiao-si HUANG Jia-bin LIU Kang-an Objective To explore the preventive effect of interference electrical therapy on muscle atrophy in patients with subconscious disorder in intensive care. Methods A total of 40 patients with disorders of consciousness admitted to Jieyang People′s Hospital from January 2017 to June 2020 were selected as the research subjects and divided into the experimental group (20 cases) and the control group (20 cases) according to the random number table method. Patients in the control group were treated by passive movement method only, and patients in the experimental group were treated by adding 1 time/d interferential electrotherapy on top of the control group. The changes in the cross-sectional areas of the anterior femoral compartment (AT), posterior femoral compartment (PT), anterior leg compartment (AL) and posterior leg compartment (PL) of the two groups were compared by CT observation, and the changes in the ratio of muscle cross-sectional area were calculated using the muscle cross-sectional area at the time of admission as 100% to characterize the preventive effect of interferential electrotherapy on muscle atrophy in patients. Interferential electrical therapy was discontinued when the patient′s lower extremity mobility or level of consciousness improved. Results The level of consciousness improved in 6 patients in the experimental group during the treatment with interferential electrotherapy, and the percentages of AT, PT, AL and PL area were higher in the patients than those in the control group,and the differences were statistically significant (P＜0.05); the percentage of thigh muscle cross-sectional area in 14 patients in the experimental group after receiving interferential electrotherapy was higher than that in the control group at days 14, 21, 28, 35 and 42 of treatment, and the difference was statistically significant (P＜0.05). Conclusion Interference electrical therapy can effectively prevent muscle atrophy in patients with subconscious disorder in intensive care,help maintain the patient′s muscle function, and lay a good foundation for rehabilitation after the patient wakes up. 2021 Vol. 28 (19): 49-52 [Abstract] ( 46 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 53 Clinical effect of Huafu Shengji Paste combined with micro-aerobic therapy in the treatment of stage Ⅳpressure ulcer CHEN De-jian GENG Xiao-ying ZHOU Ling-fang TAO Ai-ai YANG Qiao-ping YU De-hua CHEN Hong-gui Objective To analyze the clinical therapeutic effect of Huafu Shengji Paste combined with micro-aerobic therapy in the treatment of patients with stage Ⅳpressure ulcers. Methods Forty patients with stage Ⅳpressure ulcers who received the treatment in Dermatology Department of Xinghua Traditional Chinese Medicine Hospital from April 2019 to June 2020 were selected as the research subjects. The patients were divided into experimental group (20 cases)and control group (20 cases) by random number table method. The patients in the experimental group were treated with Huafu Shengji Paste combined with micro-aerobic therapy, and the patients in the control group were treated with sterile petrolatum. Both groups received debridement and systemic care. The overall response rates of wound area reduction, wound tissue type change, and wound exudate reduction were compared between the two groups after 2 and 4 weeks of treatment; the length, width, depth, area, and volume of the wound before treatment and after 2, 4 weeks of treatment of the two groups were compared; the overall response rate of wound repair were compared between the two groups after 4 weeks of treatment. Results The overall response rates of wound area reduction, wound tissue type change, wound exudate volume reduction in the experimental group were higher than those of the control group after 2 and 4 weeks of treatment, the length, width, depth, area, and volume of wound in the experimental group were all lower than those of the control group after 2 and 4 weeks of treatment, with statistically significant differences (P＜0.05). In the experimental group, the overall response rates of wound area reduction, wound tissue type change, wound exudate volume reduction after 4 weeks of treatment were higher than those after 2 weeks of treatment, the length, width, depth,area, and volume of wound after 4 weeks of treatment were lower than those after 2 weeks of treatment, and the differences were statistically significant (P＜0.05). In the control group the overall response rates of wound area reduction,wound tissue type change, wound exudate volume reduction, after 4 weeks of treatment were ligher than those after 2 weeks of treatment, the differencces were statistically significant (P＜0.05). In the control group, there were no statistical differences in the length, width, depth, area, and volume of wound between 4 weeks of and 2 weeks of treatment (P＞0.05). The overall response rate of wound recovery in the experimental group was higher than that in the control group after 4 weeks of treatment, and the difference was statistically significant between the two groups (P＜0.05). Conclusion The Huafu Shengji Paste combined with micro-aerobic therapy in the treatment of stage Ⅳpressure ulcers has a good effect, favorable recovery, and mild side effects, and can significantly improve quality of life of patients, and it is worthy of clinical promotion. 2021 Vol. 28 (19): 53-57 [Abstract] ( 47 ) HTML (42 KB)  PDF  (0 KB)  ( 6 ) 58 Clinical comparison of two different injectors in the percutaneous vertebroplasty treatment of osteoporotic vertebral compression fractures HUANG Hong-wei HUANG Jian XIE Yong-hui CHEN Gang LI Shi-han LIANG Zhi-hao Objective To investigate the clinical effect of two different injectors in the percutaneous vertebroplasty(PVP) treatment of osteoporotic vertebral compression fractures. Methods Clinical data of 168 patients with osteoporosis vertebral compression fracture with PVP were analyzed retrospectively from January 2019 to March 2020 in the Department of Spinal Orthopedics, Yangjiang People′s Hospital, Guangdong Province. They were divided into observation group(84 cases) and control group (84 cases) according to the different of bone cement injector in PVP. The observation group was treated with side hole bone cement injector, while patients in the control group were treated with traditional anterior opening bone cement injector. The visual analogue scale (VAS) score before and after operation, the distribution rate of bone cement along bone fracture line, the leakage rate of bone cement, the incidence of vertebral collapse/fracture and the incidence of adjacent vertebral fracture were compared between the two groups. Results There was no significant difference in preoperative VAS score between the two groups (P＞0.05).There was no significant difference in VAS score between the two groups on the first day after operation(P＞0.05).The VAS score of the observation group and the control group after operation was lower than that before operation,and the difference was statistically significant(P＜0.05). The distribution rate of bone cement along fracture line in the observation group was higher than that in the control group, the difference was significant (P＜0.05). The incidence rates of vertebral collapse/fracture and adjacent vertebral fracture in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion In PVP, the use of side hole bone cement injector and traditional bone cement injector in the treatment of osteoporotic vertebral compression fractures, both can achieve good clinical efficacy, but the use of side hole bone cement injector surgery patients, bone cement along the broken line distribution rate is higher, bone cement leakage rate,vertebral collapse/fracture rate and adjacent vertebral fracture rate is lower, it is worthy of clinical promotion. 2021 Vol. 28 (19): 58-61 [Abstract] ( 52 ) HTML (37 KB)  PDF  (0 KB)  ( 6 ) 62 Clinical effect and safety of traditional open surgery in the treatment of acute adhesive intestinal obstruction AN Jun Objective To study the clinical effect and safety of traditional open surgery in the treatment of acute adhesive intestinal obstruction. Methods A total of 122 patients with acute adhesive intestinal obstruction who were treated in Haicheng Central Hospital from January 2018 to January 2020 were selected as the research objects. The subjects were divided into two groups according to the random number table method, with 61 cases in each group. Patients in the control group were treated with conservative non-surgical method, while patients in the experimental group were treated with traditional open surgery. The clinical treatment effect, remission time of related symptoms, recovery time and incidence of complications between the two groups were compared and analyzed. Results The total effective rate of treatment in the experimental group was higher than that in the control group (93.44% vs. 77.05%), and the difference was statistically significant (P＜0.05). The total incidence of complications in the experimental group was lower than that in the control group (6.56% vs. 19.67%), the difference was statistically significant (P＜0.05). The remission time of related symptoms and recovery time in the experimental group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Traditional open surgery for the treatment of acute adhesive intestinal obstruction, its clinical treatment effect is significant, with high safety, can shorten the remission time of clinical symptoms and recovery time of patients, reduce the incidence of complications, promote the recovery of patients′body function, thereby effectively improving the quality of life of patients, which has more promotion and application value in the future clinical work, and should be given priority. 2021 Vol. 28 (19): 62-64 [Abstract] ( 49 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 65 Clinical observation of desitabine in the treatment of myelodysplastic syndrome and acute myeloid leukemia WU Guang-lei Objective To investigate the clinical application effect and drug safety of desitabine in the treatment of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Methods A total of 92 patients (including 22 cases of MDS and 70 cases of AML) admitted to Department of Hematology, the First Hospital of Nanping City of Fujian Province from March 2017 to March 2020 were selected as the research objects. The patients were divided into the study group (46 cases) and the control group (46 cases) according to the drug therapy. The control group was treated with Malfarin combined with Prednisone Acetate, while the control group was treated with Decitabine. The clinical efficacy and adverse reactions of the two groups were compared. Results The total effective rate in the study group(71.74%) was higher than that in the control group (32.61%), and the difference was statistically significant (P＜0.05).The incidence of myelosuppression with fever in the study group (60.87%) was higher than that in the control group(21.74%), and the difference was statistically significant (P＜0.05). The incidence of nausea and vomiting in the study group was 13.04% (6/46), the incidence of pulmonary infection was 6.52% (3/46), and the incidence of mild diarrhea was 6.52% (3/46), which showed no statistical significance compared with 4.35% (2/46), 4.35% (2/46), 2.17% (1/46) in the control group (P＞0.05). Conclusion Decitabine treatment of MDS and AML has certain clinical efficacy and high clinical application value, but it may increase the risk of myelosuppression to some extent. 2021 Vol. 28 (19): 65-37转71 [Abstract] ( 50 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 68 Characteristics and drug resistance of pathogenic bacteria in the bile of patients with gallbladder stones and cholecystitis ZHANG Tao SHI Qing-long WANG Hong-lu  Objective To investigate the characteristics and drug resistance of pathogenic bacteria in the bile of patients with gallbladder stones and cholecystitis. Methods A total of 182 patients with gallbladder stones and cholecystitis who were admitted to Beijing Liangxiang Hospital from June 2017 to June 2020 were selected as the research objects and the characteristics of pathogenic bacteria in their bile and the drug resistance of the main pathogens were analyzed. Results A total of 191 pathogenic bacteria were detected, including 130 Gram-negative bacteria (68.06%), 53 Gram-positive bacteria (27.75%), and 8 fungi (4.19%). Enterobacter Cloacae was naturally resistant to Ampicillin/Ceftazolin, Ampicillin/Sulbactam. Klebsiella Pneumoniae was naturally resistant to Ampicillin, Cefuroxime and Ceftriaxone.The resistance rates of Escherichia Coli to Ampicillin/Sulbactam, Cefotaxime, Ampicillin, Cefazolin, Cefuroxime, Ceftriaxone and piperacillin were ＞50%. The resistance rates of Enterobacter Cloacae resistant to Aztreonam, Ceftazidime,Cefotaxime, Cefuroxime, Ceftriaxone, Amoxicillin, Clavulanate Potassium and Nitrofurantoin were all ＞60%. Klebsiella Pneumoniae resistance to common antibacterial drugs was less than 40%. The drug resistance rates of the main Gramnegative bacteria to Meropepenem and Amikacin were all less than 10%. The resistance rates of Enterococcus Faecalis to Ampicillin and nitrofurantoin were 0%. The main Gram-positive bacteria resistant to Linezolid, Vancomycin and Tigecycline, the rates were all 0%, and the resistance rates to Clindamycin and Erythromycin were both ＞85%. The resistance rate of Enterococcus Faecium to Rifampin was ＞85%. Conclusion Bile culture of gallbladder stones with cholecystitis is mainly infected by gram-negative bacteria. There are obvious differences in drug resistance of different pathogens. It is necessary to select antibiotics reasonably according to the results of drug susceptibility, improve the therapeutic effect, and be alert to the emergence of multi-drug resistant bacteria. 2021 Vol. 28 (19): 68-71 [Abstract] ( 41 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 72 Application of combined blood purification in patients with severe acute pancreatitis CUI Juan WANG Bo XU Wen SHI Yong-tao CHEN Jun GUO Jian-bo▲ Objective To investigate the application of combined blood purification therapy (CBP) in patients with severe acute pancreatitis (SAP). Methods From February 2019 to February 2020, 76 patients with severe acute pancreatitis treated in the Intensive Care Unit (ICU), People′s Hospital of Xiangzhou District were selected as the research objects. They were divided into the reference group and the test group according to the random number table method, with 38 cases in each group. The patients in the reference group were treated with oxygen therapy, fasting water, nutritional support,anti-shock,anti-inflammatory,anti-pancreatic enzyme and so on.The test group was treated with CBP(hemofiltration+hemoperfusion) on the basis of routine comprehensive treatment. The levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), mortality, blood amylase recovery time, ICU stay and total hospital stay in the two groups were compared. Results Before treatment, there were no statistically significant differences in the levels of CRP, IL-6 and TNF-α between the two groups (P＞0.05). After treatment, the levels of CRP, IL-6 and TNF-α in the groups were lower than those before treatment, the differences were statistically significant (P＜0.05), and the levels of CRP, IL-6 and TNF-α in test group were lower than those in the reference group, the differences were statistically significant (P＜0.05). The mortality of the test group was lower than that of the reference group, and the recovery time, ICU residence time and total hospitalization time of the test group were shorter than those of the reference group,and the differences were statistically significant (P＜0.05). Conclusion CBP adjuvant routine treatment in patients with severe acute pancreatitis can effectively reduce the level of inflammatory factors, improve mortality and shorten the recovery time. 2021 Vol. 28 (19): 72-74 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 7 ) 75 Effect of Liaoxuan Kaxifu Pills treating moderate to severe scalp seborrheic dermatitis QI Xing-yan  Objective To investigate the effect of Liaoxuan Kaxifu Pills treating moderate to severe scalp seborrheic dermatitis (SSD). Methods A total of 116 patients SSD admitted to the Seventh People′s Hospital of Shenyang City from October 2017 to may 2020 were selected as the research objects and divided into the experimental group and the control group by simple randomilization, with 58 cases in each group. The patients in the experimental group were treated with Liaoxuan Kaxifu Pills combined with Ketoconazole Lotion, while the patients in the control group were treated with Ketoconazole Lotion. The total effective rate, symptom score and quality of life were compared between the two groups. Results The total effective rate in experimental group (94.83%) was higher than that in control group(82.76%), and the difference was statistically significant (P＜0.05). The pruritus score ([0.92±0.06] points), scale score([1.24±0.23] points) and papule score ([1.19±0.21] points) in experimental group were lower than those in control group([1.63±0.25], [1.72±0.34], [1.63±0.27] points), and the differences were statistically significant (P＜0.05). Concise health measurement scales (SF-36) scores in experimental group were higher than those in control group, and the differences were statistically significant (P＜0.05). Conclusion Liaoxuan Kaxifu Pills is helpful to relieve the symptoms of pruritus and scales in patients with moderate to severe SSD, and improve its overall efficacy. 2021 Vol. 28 (19): 75-77 [Abstract] ( 58 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 78 Application effect of SBAR communication model on the transportation of the patients receiving cardiac interventional therapy YU Ling YAN Qiong▲ HUO Xue-qin Objective To investigate the effect of SBAR communication model on the transportation of the patients received cardiac interventional therapy. Methods A total of 156 patients who received cardiac interventional therapy from March to May 2018 in the First Affiliated Hospital of Nanchang University were divided into observation group and control group according to the simple randomization method, with 78 cases in each group. The patients in observation group was treated with SBAR communication model, and the control group was treated with traditional model. The satisfaction of nurse and patients and the occurrence rates of interventional adverse events were compared between two groups. Results The satisfaction degree of nurses in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The patients′nursing satisfaction in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant(P＜0.05). Conclusion SBAR communication model can guarantee security of the patients receiving cardiac interventional therapy, reduce the occurrence of adverse events, improve the quality of care and promote doctor-patient harmony. 2021 Vol. 28 (19): 78-81 [Abstract] ( 47 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 82 Influence of Valsartan on inflammatory indexes and lipid metabolism levels in patients with coronary heart disease LIU Wen-dong LI Qiao-min WANG Jie-ying Objective To study the influence of Valsartan on inflammatory indexes and lipid metabolism levels in patients with coronary heart disease. Methods A total of 65 patients with coronary heart disease in Binhaiwan Central Hospital of Dongguan City from October 2017 to October 2018 were selected and divided into the control group (n=32)and the observation group (n=33) according to the random number table method. The control group was treated with Atorvastatin Calcium on the basis of conventional treatment, and the observation group was treated with Valsartan on the basis of the treatment of the control group. Inflammatory indexes, blood lipids, changes in the size of coronary plaque before and after treatment and adverse events within one year were observed in the two groups. Results After treatment,the levels of C-reactive protein, tumor necrosis factor-α, total cholesterol, triacylglycerol and low-density lipoprotein cholesterol in the observation group were lower than those in the control group, the levels of serum adiponectin and high-density lipoprotein cholesterol in the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). After treatment, the areas of fibrous plaques, lipid plaques, mixed plaques and calcified plaques in the observation group were smaller than those in the control group, and the differences were statistically significant (P＜0.05). The total incidence of adverse events in the observation group at one year after treatment was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Valsartan can stabilize the inflammatory indicators of patients with coronary heart disease, improve lipid metabolism, reduce the area of coronary plaques, and reduce the occurrence of adverse events. 2021 Vol. 28 (19): 82-85 [Abstract] ( 46 ) HTML (34 KB)  PDF  (0 KB)  ( 6 ) 86 Observation on the effect of intravenous thrombolysis with Recombinant Human Prourokinase in the treatment of acute ST-segment elevation myocardial infarction XUE Hou-jun HE Ting Objective To investigate the effect of intravenous thrombolysis with Recombinant Human Prourokinase in the treatment of acute ST-segment elevation myocardial infarction. Methods A total of 94 patients with acute ST-segment elevation myocardial infarction admitted to the Second People′s Hospital of Honghu City in Hubei Province from October 2018 to June 2020 were selected as the research objects, and they were divided into the control group (47 cases) and the observation group (47 cases) according to the odd-even method. The control group was treated with Urokinase thrombolytic therapy, and the observation group was treated with Recombinant Human Prourokinase therapy. The vascular recanalization rate, the total bleeding rate, and the mortality of the two groups were compared. Results The blood vessel recanalization rate of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The total bleeding rate of the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The mortality of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Recombinant Human Prourokinase intravenous thrombolysis in the treatment of acute ST-segment elevation myocardial infarction can increase the vascular recanalization rate and reduce the bleeding rate after treatment, the mortality of patients is extremely low. 2021 Vol. 28 (19): 86-88转92 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 89 Application effect of Tolvaptan in elderly patients with heart failure CHENG Su Objective To explore the application effect of Tolvaptan in the treatment of heart failure in elderly patients.Methods From September 2017 to September 2020, 80 elderly patients with heart failure admitted to Hongshan District Hospital of Traditional Chinese Medicine in Wuhan City were selected as the research objects, and the patients were divided into the observation group (40 cases) and the control group (40 cases) by random number table method. Patients in the control group were given conventional anti-heart failure treatment, and the observation group was given Tolvaptan on the basis of the control group. The recovery of heart function, related laboratory indicators and 24-hour urine output between the two groups of patients before and after treatment were compared. Results After treatment, the left ventricular ejection fraction (LVEF) of the observation group was higher than that of the control group, while the left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), and heart rate (HR) of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). After treatment, the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and serum galectin (Gal-3) of the observation group were lower than those of the control group, and the serum sodium ion (Na+) concentration, the 24-hour urine output of the observation group were higher than those of the control group, the differences were statistically significant (P＜0.05). There was no statistical difference in the serum potassium ion (K+) concentration between the two groups after treatment (P＞0.05). Conclusion Tolvaptan can significantly improve the heart function of patients with heart failure, promote the increase of urine output and blood sodium concentration in patients, and the effect is significant. 2021 Vol. 28 (19): 89-92 [Abstract] ( 44 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 93 Comparison of the efficacy of Amisulpride and Aripiprazole in improving the cognitive function of patients with schizophrenia YU Li-hua GONG Fa-jin ZHANG Yong-mei Objective To investigate the efficacy of Amisulpride and Aripiprazole in improving the cognitive function of patients with schizophrenia. Methods A total of 80 patients with schizophrenia admitted to Jiangxi Mental Hospital from August 2018 to July 2020 were selected as research subjects. They were divided into the observation group and the control group according to the random number table method, with 40 cases in each group. The observation group was treated with oral Amisulpride Tablets, and the control group was treated with oral Aripiprazole Tablets. The positive and negative symptom scale (PANSS) score, patient health questionnaire depression scale (PHQ-9) score and mini mental state scale (MMSE) score were compared between the two groups before and after 2 months of treatment. Results The PANSS scores of the two groups after treatment were lower than those before treatment, and PANSS scores of the observation group after treatment were lower than those of the control group, the differences were statistically significant (P＜0.05). There was no statistical significance in the comparison of PHQ-9 score between the two groups before treatment (P＞0.05). The PHQ-9 scores of the two groups after treatment were lower than those before treatment, and PHQ-9 scores of the observation group after treatment were lower than those of the control group, the differences were statistically significant (P＜0.05). MMSE scores in the two groups after treatment were higher than those before treatment, and the MMSE score in the observation group after treatment was higher than that in the control group, the differences were statistically significant (P＜0.05). Conclusion Compared with Aripiprazole, Amisulpride is more beneficial to relieve symptoms and depression and improve cognitive function in patients with schizophrenia. It is a more ideal drug choice. 2021 Vol. 28 (19): 93-95 [Abstract] ( 57 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 96 Application of 3D guide plate in minimally invasive soft channel puncture and drainage for hypertensive intracerebral hemorrhage ZENG Duo QI Qiong-yao YE Shi-yang HU Bin LIU Chuan-jin HU Dao Objective To investigate the application effect of 3D guide plate in minimally invasive soft channel puncture and drainage for hypertensive intracerebral hemorrhage (HICH). Methods A total of 40 patients with HICH treated in Pingxiang People′s Hospital from January 2019 to September 2020 were selected as the research subjects according to the random number table method, they were divided into the control group (n=20) and the observation group (n=20).The control group was treated with stereotactic drainage, the observation group was treated with 3D guide plate soft channel puncture and drainage, the patients were followed up until 8 weeks after operation. The degree of neurological deficit, serum neuron specific enolase (NSE) and central neurological specific protein (S100-β) levels before and 8 weeks after operation were compared between the two groups, the occurrence of postoperative intracranial infection was counted between the two groups. Results Before operation, there was no statistical significant difference in the comparison of the National Institutes of Health Stroke Scale (NIHSS) scores of both groups (P＞0.05); 8 weeks after operation,the NIHSS scores of both groups were lower than those before operation, and the NIHSS score of the observation group was lower than that of the control group, there were statistical significant differences (P＜0.05); before operation, there was no statistical significant difference in the comparison of serum NSE and S100-β levels of both groups(P＞0.05);8 weeks after operation, the serum NSE and S100-β levels of both groups were lower than those before operation, and the serum NSE and S100-β levels of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05); there was no statistically significant difference in the incidence of postoperative intracranial infection between the two groups (χ2=1.026, P=0.311). Conclusion The application effect of 3D guide plate in HICH soft channel minimally invasive puncture and drainage is better, which can effectively reduce the degree of neurological deficit and improve the neurological function of patients, and will not increase the risk of complications. 2021 Vol. 28 (19): 96-98转102 [Abstract] ( 29 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 99 Application research of CT three-dimensional visualization in cerebral aneurysm intervention WU Tao NIE Hong-bing CHENG Shu-hua YOU Jian-you ZHU Jing SHEN Yao-yao Objective To explore the application effect of CT three-dimensional visualization in cerebral aneurysm intervention. Methods A total of 30 patients with cerebral aneurysm treated in Affiliated Hospital of Jiujiang University from August 2018 to August 2020 were selected as the research subjects. According to the random number table method, they were divided into the observation group and the control group, with 15 patients in each group. The observation group was treated with CT three-dimensional visualization technology to assist the interventional treatment of cerebral aneurysms, and the control group was treated with conventional interventional embolization. The clinical efficacy, intervention time, hospital stay, Hunt-Hess classification, complications and prognosis were compared between the two groups. Results The interventional treatment time and the hospital stay in the observation group were shorter than those in the control group, and the Glasgow outcome score was higher than that in the control group, with statistical significances （P＜0.05）. There were no significant differences in the total effective rate, Hunt-Hess grading before and after operation and the total incidence of complications between the two groups （P＞0.05）. Conclusion CT three-dimensional visualization technology combined with cerebral aneurysm interventional treatment can save operation time and reduce postoperative complications, which is beneficial to promote the rapid recovery of patients, improve the prognosis of patients,and reduce the risk of disability. The clinical application is safe and reliable. 2021 Vol. 28 (19): 99-102 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 103 Efficacy observation of making discharge plan on stroke patients with hemiplegia after discharge YU Xue-qin1 HUANG Jun2 Objective To explore the efficacy of making discharge plan on stroke patients with hemiplegia after discharge. Methods A total of 60 patients with stroke hemiplegia discharged from the Department of Rehabilitation,Yichun People′s Hospital from April 2019 to March 2020 were selected as the research subjects. They were divided into the control group and the observation group according to the random number table method, with 30 cases in each group. Patients of both groups were given routine oral medication to prevent stroke recurrence, the control group guided the general rehabilitation training after discharge, and the observation group jointly developed a detailed discharge plan by rehabilitation physicians, rehabilitation therapists and nurses, including changing the living environment, simple rehabilitation equipment, specific rehabilitation training methods, etc. The patients were followed up every 2 weeks, and different rehabilitation plans were made according to the functional level. The self-efficacy, neurological deficit score,activity of daily living index, activities of daily living (ADL) index, Fugl-Meyer assessment (FMA) score and quality of life of the two groups were observed at the time of discharge and 3 months after discharge, and the efficacy of upper limb muscle tension, lower limb muscle strength and compliance were evaluated. Results There were no statistically significant difference in the scores of self-efficacy and neurological deficit degree between the two groups at discharge(P＞0.05). Three months after the discharge, the self-efficacy of two groups was higher than that at discharge, while the self-efficacy of the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05). Three months after the discharge, the neurological deficit degree of two groups was lower than that at discharge, while the neurological deficit degree of the observation group was lower than that of the control group, and the differences were statistically significant (P＜0.05). There were no significant differences in ADL, FMA and quality of life scores between the two groups at discharge (P＞0.05).Three months after the discharge, the ADL, FMA and quality of life scores of two groups were lower than those at discharge, while the ADL, FMA and quality of life scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The efficacy of the upper and lower limb muscle tension of the observation group was higher than that of the control group, and the differences were statistically significant(P＜0.05). The compliance (taking medication on time, controlling tobacco and alcohol control, rehabilitation training,reasonable diet, self-monitoring, re-visit and visit on time) of the observation group was higher than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The development of discharge plan has a good effect on stroke hemiplegic patients after discharge. It can improve the patients′ self-efficacy, neurological deficit score, activity of daily living index, activity of daily living index, FMA score and quality of life, and improve the upper limb muscle tension efficacy, lower limb muscle strength efficacy and patients′ compliance. 2021 Vol. 28 (19): 103-106 [Abstract] ( 43 ) HTML (39 KB)  PDF  (0 KB)  ( 6 ) 107 Clinical effect of Taijiquan intervention in the treatment of insomnia WANG Xiu-juan CHEN Ya-chun ZHANG Si-xi Objective To explore the clinical effect of Taijiquan intervention in the treatment of insomnia. Methods A retrospective analysis of 80 patients with insomnia admitted to the Second Affiliated Hospital of Jiangxi University of Chinese Medicine from December 2016 to June 2018 was made and they were divided into the control group (40 cases)and the observation group (40 cases) according to different intervention methods, the control group was treated with sleep hygiene education method, and the observation group was treated with 48-style Taijiquan. Patients in both groups intervened for two months. The clinical efficacy and Pittsburgh sleep quality index (PSQI) scores of patients before and after intervention were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group, the differences were statistically significant (P＜0.05). Before the intervention,there were no statistically significant differences between the two groups before the intervention in the time to fall asleep, sleep quality, sleep time, sleep efficiency, sleep disturbance, daytime function and total PSQI score (P＞0.05).After the intervention, the time to fall asleep, sleep quality, sleep time, sleep efficiency, sleep disturbance, daytime function and PSQI total scores of the observation group after intervention were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Taijiquan intervention can effectively prolong the sleep time of patients with insomnia, improve their sleep quality. 2021 Vol. 28 (19): 107-109 [Abstract] ( 46 ) HTML (29 KB)  PDF  (0 KB)  ( 9 ) 110 Clinical effect of CT-guided stereotactic technique through frontal approach in the treatment of severe thalamic hemorrhage LU Zhi-jin TANG Tao XIAO Yan-ping ZENG Fan-yun Objective To explore the clinical application of stereotactic treatment of severe hemorrhage in the hypothalamus Discussion CT-guided stereotactic approach by the amount. Methods A total of 81 patients with severe thalamic hemorrhage admitted to Ganzhou People′s Hospital from March 2017 to May 2019 were selected as the research object. According to the random number table method, they were divided into the control group (n=40) and the treatment group (n=41). The control group was treated with bilateral ventricle drilling and drainage; the treatment group was treated with CT-guided stereotactic technique to guide brain drilling and drainage under the guidance of transfrontal approach stereotactic technique, all patients were observed for 2 weeks after surgery. The clinical efficacy, clinical related indicators, postoperative complications, and serum inflammatory factor levels before and 3 days after operation were compared between the two groups. Results The total clinical effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P＜0.05). The indwelling drainage tube,recovery of consciousness and Intensive Care Unit (ICU) stay in the treatment group were shorter than those in the control group, the differences were statistically significant (P＜0.05). The total postoperative complication rate in the treatment group was lower than that of the control group, the differences were statistically significant (P＜0.05). Before surgery, there were no significant differences in serum inflammatory factor levels between the two groups (P＞0.05);3 days after surgery, serum tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-6 levels in the treatment group were lower than those in the control group, and the differences were statistically significant (P＜0.05).Conclusion CT-guided stereotactic technology through the frontal approach stereotactic technology in the treatment of patients with severe thalamic hemorrhage can effectively reduce surgical trauma, with better curative effect, and reduce postoperative complications. 2021 Vol. 28 (19): 110-112 [Abstract] ( 40 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 113 Effect of minimally invasive hematoma removal combined with Urokinase in the treatment of hypertensive basal ganglia cerebral hemorrhage and its effect on neurological function CAI Dan-hui LIN Jin-feng Objective To investigate the effect of minimally invasive hematoma removal combined with Urokinase in the treatment of hypertensive intracerebral hemorrhage (HICH) in the basal nucleus area and its influence on nerve function. Methods A total of 80 patients with HICH in basal ganglia region admitted to Jieyang People′s Hospital from March 2016 to October 2020 were selected as the research subjects. They were divided into control group (40 cases)and observation group (40 cases) by random number table method. The control group was treated with routine craniotomy hematoma removal, and the observation group was treated with minimally invasive hematoma removal combined with Urokinase. Glasgow coma score (GCS), neurological function scale score (NIHSS) and postoperative complications were compared between two groups. Results The GCS score of the observation group was higher than that of the control group after 1 and 3 months of treatment, and the NIHSS score of the observation group was lower than that of the control group, the differences were statistically significant (P＜0.05). The incidence of pulmonary infection in observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in the incidence of intracranial infection between the two groups (P＞0.05). Conclusion Minimally invasive hematoma removal combined with Urokinase therapy in patients with basal ganglia HICH can improve the patient′s neurological function, reduce the incidence of coma, and have fewer postoperative complications. 2021 Vol. 28 (19): 113-115 [Abstract] ( 27 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 116 Effect of high-frequency repetitive transcranial magnetic stimulation on nicotine craving in patients with depression WEN Shu-yuan LIAO Juan-ping LI Hai-yan LI Su-fang DENG Hong-dong Objective To investigate the effect of high-frequency repetitive transcranial magnetic stimulation on nicotine craving in patients with depression. Methods Retrospective analysis was conducted on the data of 90 patients with depression admitted to Department of Psychiatry, the Third People′s Hospital of Ganzhou from January 2018 to January 2020. The patients were grouped according to different treatment methods and divided into the control group and the study group, with 45 cases in each group. The control group received conventional drug therapy, while the study group received high-frequency repetitive transcranial stimulation on the basis of drug therapy. The Fagerstrom test of nicotine dependence (FTND) was used to evaluate the nicotine craving before and after treatment, and the Hamilton depression scale (HAMD) was used to evaluate the treatment effect. Meanwhile, the changes of neurotransmitter levels before and after treatment were compared and observed in the two groups. Results There was no statistically significant difference in FTND score in the control group before and after treatment (P＞0.05). The FTND score in the study group after treatment was lower than that before treatment, and lower than that in the control group, the differences were statistically significant (P＜0.05). After treatment, the HAMD score of the study group was lower than that of the control group, while the serum levels of 5-hydroxytryptophan (5-HT), dopamine (DA) and gamma-aminobutyric acid (GABA) were higher than those of the control group the differences were statistically significant (P＜0.05). Conclusion In the treatment of patients with depression, high-frequency transcranial magnetic stimulation can effectively regulate the function of neurons, reduce the patients′ nicotine craving, and promote the improvement of clinical efficacy. 2021 Vol. 28 (19): 116-119 [Abstract] ( 45 ) HTML (34 KB)  PDF  (0 KB)  ( 9 ) 120 Effect of Alteplase combined with Butylphthalide in the early treatment of acute ischemic stroke and its influence on the level of fibrinogen WAN Ting-yu WANG Dan Objective To investigate the effect of Alteplase combined with Butylphthalide in the early treatment of acute ischemic stroke and its influence on the level of fibrinogen. Methods From October 2018 to October 2020, 136 patients with acute ischemic stroke in People′s Hospital of Jiangmen, Guangdong Province were divided into the Alteplase group (68 cases, intravenous thrombolytic therapy with Alteplase) and the combination group (68 cases, intravenous infusion of Butylphthalide Sodium Chloride Injection on the basis of Alteplase intravenous thrombolytic therapy)according to the random number table method. The neurological deficit score before and 24 hours after thrombolysis,the levels of fibrinogen before and 1 and 4 hours after thrombolysis and curative effect were compared between the two groups. Results At 24 hours after thrombolysis, the neurological deficit scores of the two groups were lower than those before thrombolysis, and the neurological deficit score of the combination group was lower than that of the Alteplase group, the differences were statistically significant (P＜0.05). The total effective rate of treatment in the combination group was higher than that in the Alteplase group, and the difference was statistically significant (P＜0.05). The fibrinogen levels of the two groups at 1 and 4 h after thrombolysis were lower than those before thrombolysis, the differences were statistically significant (P＜0.05), and the fibrinogen levels of the combined group were lower than those of the Alteplase group, the differences were statistically significant (P＜0.05). Conclusion Alteplase combined with Butylphthalide has a significant effect in the early treatment of acute ischemic stroke, which is conducive to the improvement of neurological function and can reduce the level of fibrinogen. 2021 Vol. 28 (19): 120-122转126 [Abstract] ( 45 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 123 Effect analysis of life skills training on hospitalized patients with chronic schizophrenia ZHANG Ying1 CAO Shu-hua2 KE Wen-ying3 WEN Yan-wen4 Objective To investigate the effect of life skills training on hospitalized patients with chronic schizophrenia.Methods A total of 80 patients with chronic schizophrenia who were admitted to Wu zhongwei Memorial Hospital from October 2017 to October 2018 were selected as the research objects and divided into control group (40 cases) and observation group (40 cases) according to random number table method. The control group was treated with conventional medicine, and the experimental group was treated with life skills training on the basis of the control group. The nurse observation scale (NOSIE) and the living ability scale (ADL), which consisted of the physical self-care scale (PSMS)and the instrumental activities of daily living scale (IADL),were compared between the two groups. Results After the intervention, the positive factor score of NOSIE in the observation group was higher than that in the control group, and the negative factor score was lower than that in the control group,and the differences were statistically significant(P＜0.05).After intervention, the PSMS and IADL scores in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Life skill training can improve the daily living ability and social function of hospitalized patients with chronic schizophrenia, which is worthy of clinical promotion. 2021 Vol. 28 (19): 123-126 [Abstract] ( 51 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 127 Phosphorus lowering effect of Lanthanum Carbonate in patients with end-stage renal disease and its effect on vascular calcification FENG Wei-xun HAN Wei XUE Cai-li Objective To investigate the phosphorus lowering effect of Lanthanum Carbonate in patients with end-stage renal disease and its effect on vascular calcification. Methods A total of 260 patients with end-stage renal disease admitted to Dingzhou People′s Hospital from January 2017 to January 2020 were selected as the research objects, and they were divided into the observation group (130 cases) and the control group (130 cases) by computer random drawing. Both groups were treated with hemodialysis, while patients in the observation group were treated with Lanthanum Carbonate, and patients in the control group were treated with Calcium Carbonate. Blood calcium, blood phosphorus,calcium phosphorus products and blood parathyroid hormone (PTH) levels were compared between the two groups at different time points (immediately after treatment, 2 weeks after treatment, 4 weeks after treatment, 8 weeks after treatment, and 12 weeks after treatment). The time when the blood phosphorus levels of the patients in the two groups returned to normal was recorded. The total incidence of adverse reactions in the two groups during medication was counted. Results After 2, 4, 8 and 12 weeks of treatment, serum calcium, blood phosphorus, calcium phosphorus products and blood PTH levels in the observation group were lower than those in the control group, serum calcium in the observation group after 4, 8 and 12 weeks of treatment were lower than those in the control group, and the differences were statistically significant (P＜0.05). The time of blood phosphorus levels in the observation group returning to normal was (30.59±5.61) d, which was shorter than (39.86±6.02) d in the control group, and the difference was statistically significant (P＜0.05). The total incidence of adverse reactions in the observation group (3.85%) was lower than that in the control group (13.07%), and the difference was statistically significant (P＜0.05). Conclusion Lanthanum Carbonate can significantly reduce the level of serum phosphorus in patients with end-stage renal disease, and has no significant effect on the level of serum calcium, which has high safety and is worthy of clinical use. 2021 Vol. 28 (19): 127-129转133 [Abstract] ( 38 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 130 Application study of high flux hemodialysis combined with hemoperfusion in the treatment of uremia RUAN Chun-yun LIU Sheng-shan Objective To explore the application of high flux hemodialysis combined with hemoperfusion in the treatment of uremia. Methods A total of 80 patients with uremia admitted to the Department of Nephrology, the Third Hospital of Nanchang from April 2020 to July 2020 were selected as the research objects and divided into the control group (40 cases) and the observation group (40 cases) according to the random sampling. The control group was given high flux hemodialysis treatment, and the observation group was given hemoperfusion treatment on the basis of the control group, patients of both groups were treated continuously for 12 weeks. The changes of toxin clearance index, inflammatory factors and immune function before treatment and 12 weeks after treatment were compared between the two groups. Results After 12 weeks of treatment, the serum creatinine (Scr), blood urea nitrogen (BUN), parathyroid hormone(Pth), β2-microglobulin (β2-MG) and serum C-reactive protein ( CRP), serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) levels were lower than those before treatment in this group, and the observation group was lower than the control group; while serum immunoglobulin A (IgA) and immunoglobulin G ( IgG), immunoglobulin M (IgM) levels and complement C3, C4 levels were higher than those before treatment in this group, and the observation group was higher than the control group, the differences were statistically significant (P＜0.05). Conclusion High-flux hemodialysis combined with hemoperfusion can effectively remove various toxins in uremic patients, thereby reducing inflammatory factors, improving the immunity of uremic patients, and promoting the improvement of their condition. 2021 Vol. 28 (19): 130-133 [Abstract] ( 49 ) HTML (34 KB)  PDF  (0 KB)  ( 7 ) 134 Effect of Tacrolimus combined with low-dose glucocorticoid in the treatment of nephrotic syndrome TAN Jing Objective To investigate the effect of Tacrolimus combined with low-dose glucocorticoid in the treatment of nephrotic syndrom. Methods A total of 100 patients with nephrotic syndrome admitted to Iron Coal General Hospital of Liaoning Health Industry Group from January to June 2020 were selected as the research objects. They were divided into observation group (50 cases) and control group (50 cases) according to the random lottery method. The observation group was treated with Tacrolimus and low-dose glucocorticoid, while the control group was treated with low-dose glucocorticoid. The therapeutic effect, adverse reactions and renal function indexes of the two groups were compared. Results The total effective rate of the observation group was higher than that of the control group, and the total incidence of adverse reactions was lower than that of the control group, the differences were statistically significant (P＜0.05). After treatment, the serum albumin of the observation group was higher than that of the control group, and the urea nitrogen,creatinine and 24-hours urinary albumin of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Tacrolimus combined low-dose glucocorticoid is effective in the treatment of nephrotic syndrome, which can improve the renal function of patients. 2021 Vol. 28 (19): 134-136 [Abstract] ( 52 ) HTML (29 KB)  PDF  (0 KB)  ( 7 ) 137 Application of ultrasound-guided double development line localization technique in radial artery puncture and catheterization in pediatric surgery patients YE Li-qun PAN Jie-qiong Objective To investigate the effect of ultrasound-guided double development line localization technique and blind probe touch technique on radial artery puncture and catheterization in pediatric surgery patients. Methods A total of 60 children with radial artery puncture and catheterization admitted to People′s Hospital of Huaiji County,Guangdong Province from October 2018 to September 2020 were selected as the study subjects. According to the random number table method, they were divided into the control group and the observation group, with 30 patients in each group. In the catheterization, blind probe and touch technology was used in the control group, and ultrasound-guided double development line positioning technology was used in the observation group. The first puncture success rate, puncture failure rate, puncture time and complications were compared between the two groups. Results The first puncture success rate in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05). The failure rate of puncture and catheterization in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The incidence of bleeding in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The puncture time in the observation group was shorter than that in the control group, with statistically significant difference (P＜0.05). No radial artery occlusion occurred in either group. Conclusion Ultrasound-guided dual-development line localization technology can quickly and accurately determine the puncture point, shorten the puncture time, improve the success rate of the first puncture during radial artery puncture in children, and reduce the incidence of complications. 2021 Vol. 28 (19): 137-140 [Abstract] ( 42 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 141 Application of modified multi-point method for transversus abdominis plane block in abdominal surgery ZOU Xia-yu FENG Bao-ying CHEN Hai-ming LUO Jing-cong DU Jie-qiang Objective To investigate the application effect of modified multi-point method for transverse abdominis plane block (TAPB) in abdominal surgery. Methods A total of 60 patients who received abdominal surgery in the Department of Anesthesiology of Foshan Hospital of Traditional Chinese Medicine from January 2019 to November 2020 were selected as the research objects and divided into the observation group and the control group according to the random number table method, with 30 cases in each group. The observation group was treated with improved multipoint TAPB combined with general anesthesia, while the control group was treated with simple general anesthesia. The clinical status of patients in the two groups after different anesthesia was compared. Results The visual pain scale scores of the observation group at 2 h (T1), 4 h (T2), 12 h (T3) and 24 h (T4) postoperatively were lower than those of the control group, and the differences were statistically significant (P＜0.05). The postoperative hospitalization time, catheter extraction time, first anal exhaust time, medical recovery time and fluid diet time in the observation group were all shorter than those in the control group, and the differences were statistically significant (P＜0.05). The change levels of systolic blood pressure, diastolic blood pressure and heart rate indexes in the observation group were lower than those in the control group during skin cutting and after extubation, and the differences were statistically significant (P＜0.05).Conclusion In clinical patients needing abdominal surgery, modified multi-point method for TAPB combined with general anesthesia can significantly reduce the pain degrees of patients in different time periods, and simultaneously,can also shorten hospital stay, urinary catheter extraction time, first anus exhaust time, medical recovery time and fluid diet time, which can improve the safety of patients and stabilize patients′ blood pressure and heart rate in different time periods. 2021 Vol. 28 (19): 141-143转147 [Abstract] ( 36 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 144 A case of severe anaphylactic shock caused by rapid perioperative infusion of Vancomycin in general anesthesia CHEN Feng Severe allergic reactions during the perioperative period are mostly sudden and unpredictable, the condition changes rapidly, and the cardiovascular system is often involved. During the perioperative period, blood pressure, heart rate increased, and blood oxygen saturation decreased due to insufficient circulation volume, induction of anesthesia,and various types of shock. Therefore, how to perform differential diagnosis and treatment quickly and effectively is very important. This article shares a case of severe anaphylactic shock caused by rapid infusion of Vancomycin after general anesthsia induction and intubation, and the treatment of continued operation after successful resuscitation. Learn the diagnosis and treatment process of the Expert Consensus on Diagnosis and Tredtment of Perioperative Allergic Reactions from three aspects: the monitoring focus of anaphylactic shock after perioperative general anesthesia, optimization of anesthesia management for continued operation after successful resuscitation, and preventive use of antibiotics. 2021 Vol. 28 (19): 144-147 [Abstract] ( 39 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 148 Research on Graf ultrasound screening for early diagnosis of developmental dysplaisa of the hip SHI Li-li LIN Qiong ZHONG Bin DONG Lei LI Juan HUANG Xiu-ming Objective To explore the application value of Graf ultrasound screening in the diagnosis of early developmental dysplaisa of the hip. Methods A total of 60 cases of suspected infants with early diagnosis of developmental dysplaisa of the hip from the Department of Ultrasound Medicine, Ganzhou Maternity and Child Health Hospital from April 2018 to June 2020 were selected as subjects. Taking the clinical pathological diagnosis as the gold standard, Xray and Graf ultrasound were performed on all the infants. Inspection and diagnosis results were retrospectively analyzed. The infants with developmental abnormalities were followed up. Results According to the Graf classification criteria, the 60 cases were determined, including 28 cases of type Ⅰ(46.67%) and 22 cases of Ⅱ(36.67%), 10 cases of type Ⅲ(16.67%), and 0 cases of type Ⅳ, including 14 cases of type Ⅱa (23.33%), 8 cases of type Ⅱb/c (13.33%).Eighteen children with developmental dysplasia of the hip joint were diagnosed by the gold standard. The detection rate of Graf method was 83.33%, which was higher than that of X-ray examination (20.00%), and the difference was statistically significant (P＜0.05). The accuracy, sensitivity and specificity of Graf ultrasonography were 90.00%, 83.33% and 92.86%, which were all higher than those of X-ray examination (50.00%, 16.67% and 64.29%), and the differences were statistically significant (P＜0.05). A total of 15 infants with developmental dysplasia of the hip identified by Graf ultrasonography were followed up for 3 months, of which 7 cases of type Ⅱwere converted to type Ⅰ, and 8 cases of type Ⅲwere converted to 6 cases of type Ⅰ, 2 cases of type Ⅱ. Conclusion After comparative analysis, the Graf ultrasound screening can accurately grasp the development of infants′ hip joints and diagnose children with DDH as soon as possible. The sensitivity and specificity of this examination are higher than those of X-ray examination. The Graf ultrasound is of great significance in screening infants with DDH. 2021 Vol. 28 (19): 148-150转154 [Abstract] ( 38 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 151 Diagnostic value of CT angiography in intracranial aneurysms WEI Fang Objective To explore the application value of CT angiography (CTA) in the diagnosis of intracranial aneurysms. Methods A retrospective analysis was conducted on 105 patients diagnosed with intracranial aneurysms by the results of intervention surgery or craniotomy in the First Hospital of Dandong City from January to December 2019.After admission, all patients underwent CTA and three-dimensional digital subtraction angiography (3D-DSA). The diagnostic value of CTA and 3D-DSA for small intracranial aneurysms was evaluated. Results The image scores in tumor morphology display, 3D relationship, smoothness and overall evaluation of CTA-volume reproduction (VR) and 3D-DSA were higher than those of CTA-maximum density projection (MIP), with statistically significant differences (P＜0.05).However, there were no significant differences between CTA-VR and 3D-DSA in the image scores of tumor morphology display, 3D relationship, smoothness and overall evaluation (P＞0.05). The image score of 3D-DSA in tumor vessel display was higher than that of CTA-VR and CTA-MIP, and the difference was statistically significant (P＜0.05). There was no significant difference between CTA-VR and CTA-MIP in the image score of tumor blood vessels (P＞0.05). The tumor length diameter measured by 3D-DSA was (6.19±1.73) mm, and that measured by CTA was (6.38±1.64) mm.Comparison of tumor length and diameter measured by CTA and 3D-DSA showed no statistically significant difference(P＞0.05). In 105 patients, 118 aneurysms were detected by 3D-DSA, with the detection accuracy of 98.30% (116/118),and 113 aneurysms were detected by CTA, with the detection accuracy of 94.07% (111/118). There was no significant difference in the accuracy of intracranial aneurysm detection between 3D-DSA and CTA (P＞0.05). Conclusion CTA is of relatively higher diagnostic accuracy for intracranial aneurysms, with higher images quality. 2021 Vol. 28 (19): 151-154 [Abstract] ( 45 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 155 Influence of Compound Danshen Dripping Pills assisted with Western medicine antihypertensive drugs on efficacy and blood lipid of patients with essential hypertension ZHOU Huan YU Huang-peng Objective To investigate the influence of Compound Danshen Dripping Pills assisted with Western medicine antihypertensive drugs on efficacy and blood lipid of patients with essential hypertension. Methods A total of 106 patients with essential hypertension in the Third People′s Hospital of Jiujiang City from March 2019 to March 2020 were selected as the research objects, and they were randomly divided into the control group and the study group according to the number of admission, with 53 cases in each group. The control group was treated with Western medicine antihypertensive drug Levamlodipine Besylate, while the study group was treated with Compound Danshen Dripping Pills assisted with Levamlodipine Besylate. The clinical efficacy of the two groups was compared, the changes of blood lipid indexes such as triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), total cholesterol (TC) were measured, and the incidence of adverse drug reactions was counted.Results The total effective rate of treatment in the study group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Before treatment, there were no significant differences in the blood lipid indexes between the two groups (P＞0.05). There were no statistically significant differences in the blood lipid indexes of the control group after treatment and before treatment (P＞0.05). The HDL-C in the study group after treatment was higher than that in the control group and before treatment, while the other three indexes were lower than those in the control group and before treatment, the differences were statistically significant (P＜0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P＞0.05).Conclusion Compound Danshen Dripping Pills assisted with Western medicine antihypertensive drugs can improve blood lipid related indicators in the treatment of essential hypertension, further improve the efficacy of blood pressure control, and has good safety. 2021 Vol. 28 (19): 155-157转161 [Abstract] ( 50 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 158 Study on effect of Niacin on prevention of contrast-induced nephropathy in elderly patients after coronary intervention ZHANG Ke-fei JIANG Ren-gui ZHANG Bi-long Objective To explore the effect of Niacin on prevention of contrast-induced nephropathy (CIN) in elderly patients after coronary intervention. Methods A total of 150 elderly patients with coronary intervention admitted to Ganzhou Municipal Hospital from September 2019 to November 2020 were selected as the research objects and divided into group A, group B and group C according to random number table method, with 50 patients in each group. Group A was the blank control group, group B was treated with medium dose (40 mg) of Niacin, and group C was treated with high dose (80 mg) of Niacin. The incidence of CIN, renal function indexes, serum C-reactive protein (CRP) and superoxide dismutase (SOD) levels and the incidence of adverse events were compared among the three groups. Results The incidence of CIN in group A, B and C was 16.00% (8/50), 4.00% (2/50) and 2.00% (1/50), respectively. The incidence of CIN in group B and C was lower than that in group A, and the differences were statistically significant (P＜0.05). On postoperative day 1 and 3, the serum creatinine (SCR), blood urea nitrogen (BUN), uric acid (UA) and CRP levels in groups B and C were lower than those in group A, and the serum SOD level was higher than that in group A, and the differences were statistically significant (P＜0.05). On postoperative day 1, serum SCR and CRP levels in group C were lower than those in group B, and the differences were statistically significant (P＜0.05). The total incidence of adverse events in group A, B and C was 4.00% (2/50), 12.00% (6/50) and 28.00% (14/50), respectively. The total incidence of adverse reactions in group A was lower than that in group C, and the differences was statistically significant (P＜0.017).Conclusion Intravenous infusion of Niacin 40 mg bid 24 h before and 72 h after coronary intervention in the elderly can reduce the incidence of CIN, improve renal function,inflammatory factors and oxidative stress response after coronary intervention. 2021 Vol. 28 (19): 158-161 [Abstract] ( 33 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 162 Analysis of the application status and rationality of narcotic drug prescription in a hospital ZHAO Fang ZHOU Lin-guang Objective To explore the application status and rationality of narcotic drug prescription in Peking University International Hospital. Methods A total of 500 prescriptions of narcotic drugs were randomly selected from cancer pain patients admitted to Peking University International Hospital from September 2018 to September 2020.All prescriptions were evaluated,and the types and average consumption of narcotic drugs,basic indicators of narcotic drugs prescriptions and the amount of different types of prescription were counted, and the unreasonable prescriptions were analyzed.Results Among the 500 prescriptions, Oxycodone Hydrochloride Sustained-release Tablets (specification: 10 mg/tablet)had the most prescriptions, 130 (26.00%) in total, followed by Remifentanil for injection (specification: 1 mg/piece),81(16.20%)in total.Oxycodone Hydrochloride Sustained-release Tablets(specification:10 mg/tablet)consumed 8580 mg,followed by Oxycodone Hydrochloride Sustained-release Tablets (specification: 40 mg/tablet), with a total consumption of 4720 mg. Among the 500 prescriptions, the utilization rate of injection was 34.60% (173/500), the utilization rate of generic name was 100.00% (500/500), and the average amount of each prescription was (72.81±5.13) yuan. The average prescription amount for malignant tumors of ear, nose and throat was the highest, which was (143.89±15.24) yuan. The average amount of prescription for gynecological tumor was the lowest, which was (52.45±4.35) yuan. There are 10 unreasonable prescriptions, and the unreasonable prescription rate was 2.00%. Among them, 2 sheets were inappropriate for usage and dosage, accounting for 0.4%, and 8 sheets were incompletely diagnosed clinically, accounting for 1.60%.Conclusion Oxycodone Hydrochloride Sustained-release Tablets (specification: 10 mg/tablet, 40 mg/tablet) are the most frequently used narcotic drugs in patients with cancer pain, and the overall drug use is reasonable. However, there are still a few irrational phenomena, so it is necessary to strengthen the training of related knowledge of cancer pain narcotic drugs to standardize the rationality of drug use in hospitals. 2021 Vol. 28 (19): 162-165 [Abstract] ( 37 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 166 Clinical effect of traditional Chinese medicine aromatherapy combined with ear acupoint pressing beans in the treatment of insomnia due to hyperthyroidism GUO Yan-qing YAN Xiao-hua LIU Jiao Objective To explore the clinical effect of traditional Chinese medicine aromatherapy combined with ear acupoint pressing beans in the treatment of insomnia due to hyperthyroidism. Methods Sixty patients with hyperthyroidism and insomnia treated in Pingxiang People′s Hospital in Jiangxi Province from October 2019 to October 2020 were selected as the research objects, and divided into control group (30 cases) and observation group (30 cases) according to random number table method. The control group was treated with Methimazole, and the observation group was treated with traditional Chinese medicine aromatherapy combined with ear acupoint pressing beans. The two groups were treated for 4 weeks, and the clinical efficacy, satisfaction and sleep quality of the two groups were compared. Results The total effective rate of observation group was 93.33%, higher than that of control group (73.33%), the difference was statistically significant (P＜0.05). The satisfaction of the observation group was 96.67%, higher than that of the control group (66.67%), the difference was statistically significant (P＜0.05). There were no significant differences in sleep quality scores between the two groups before treatment (P＞0.05). After treatment, the sleep quality scores of the two groups were lower than those before treatment, and the sleep quality scores of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion Traditional Chinese medicine aromatherapy combined with ear acupoint pressing beans can effectively improve the sleep quality of patients with hyperthyroidism and insomnia, the effect is significant, the patient satisfaction is higher. 2021 Vol. 28 (19): 166-168转172 [Abstract] ( 48 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 169 Effect of Sijunzi Decoction treating stomatitis after chemotherapy in patients with breast cancer HE Sun-xiang Objective To investigate the effect of Sijunzi Decoction treating stomatitis after chemotherapy in patients with breast cancer. Methods A total of 60 patients with stomatitis after breast cancer chemotherapy treated in Jiujiang Hospital of Traditional Chinese Medicine from January 2017 to November 2018 were selected as the research subjects and divided into control group and treatment group according to random number table method, with 30 cases in each group. Patients of two groups were treated with chemotherapy, the control group was treated with Kangfuxin Liquid, the treatment group was treated with Sijunzi Decoction. The clinical efficacy, immune function (CD3+, CD4+, CD8+, CD4+/CD8+), quality of life, incidence of adverse reactions, 1- and 2-year survival rates were compared between the two groups. Results The total effective rate of the treatment group was higher than that of the control group, the difference was statistically significant (P＜0.05). The levels of CD3+, CD4+, CD4+/CD8+and quality of life in the treatment group after treatment were higher than those in the control group, the differences were statistically significant (P＜0.05). There was no significant difference in CD8+level between the two groups (P＞0.05). The total incidence of adverse reactions in the treatment group was lower than that in the control group, the difference was statistically significant (P＜0.05). There were no significant differences in 1- and 2-year survival rates between the two groups (P＞0.05). Conclusion Sijunzi Decoction is effective in the treatment of stomatitis after chemotherapy in breast cancer patients, which is helpful to improve the immune function of patients, improve the quality of life, and has high safety. 2021 Vol. 28 (19): 169-172 [Abstract] ( 39 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 173 Effect of back bladder percussion combined with acupoint massage in the prevention of pulmonary infection in elderly bedridden patients GUO Fei XIE Xin-ling Objective To observe the effect of back bladder percussion combined with acupoint massage in the prevention of pulmonary infection in elderly bedridden patients. Methods A total of 100 elderly bedridden patients admitted to Ganzhou Hospital of traditional Chinese Medicine from October 2019 to October 2020 were selected as the research objects. The patients were divided into experimental group and control group according to random number table method, with 50 cases in each group. Both groups were given routine measures to prevent pulmonary infection. On this basis, the control group was treated with back bladder meridian percussion, while the experimental group was treated with back bladder meridian percussion combined with acupoint massage. The incidence of pulmonary infection in two groups was statistically analyzed. Lung function and blood gas analysis indexes were compared between the two groups before and after treatment. The sputum output within 1 week after treatment, body temperature and normal time of blood routine were compared among the patients with pulmonary infection of the two groups. Results The incidence of pulmonary infection in the experimental group was 18.0% (9/50), lower than 42.0% (21/50) in the control group, and the difference was statistically significant (P＜0.05). After treatment, the forced expiratory volume in the first second(FEV1), forced vital capacity (FVC), peak expiratory flow rate (PEF) and ventilated volume per minute (MMF) in experimental group were higher than those in control group, with statistically significant differences (P＜0.05). There was no significant difference in arterial oxygen saturation (SaO2) between the two groups before and after treatment (P＞0.05).After treatment, the partial pressure of oxygen (PaO2) in the experimental group was higher than that in the control group, and the partial pressure of carbon dioxide (PaCO2) in the experimental group was lower than that in the control group, with statistically significant differences (P＜0.05). The sputum output within 1 week after treatment of patients with pulmonary infection in the experimental group was more than that in the control group, and the time for the body temperature to return to normal and blood routine return to normal time in the experimental group were shorter than those in the control group, with statistically significant differences (P＜0.05). Conclusion The effect of back bladder percussion combined with acupoint massage in the prevention of pulmonary infection in elderly bedridden patients is good. 2021 Vol. 28 (19): 173-176 [Abstract] ( 37 ) HTML (38 KB)  PDF  (0 KB)  ( 6 ) 177 Effect of fumigation of Zijin Xiaozhong Lotion treating hemorrhoid pain and its effect on visual analog scales HUANG Xiao-dong LIANG Jing-hua▲ Objective To explore the effect of Zijin Xiaozhong Lotion treating hemorrhoids pain and the change of visual analog scale (VAS). Methods A total of 60 hemorrhoids patients with external hemorrhoids or mixed hemorrhoids in Shenzhen Anorectal Hospital from August to December 2020 were selected as the research objects. According to the method of drawing lots, they were divided into the observation group and the control group, with 30 cases in each group. The control group was treated with conventional Western medicine symptomatic treatment, and the observation group was treated with conventional western medicine+Zijin Xiaozhong Lotion fumigation combined treatment. VAS pain score, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) levels and adverse reactions were compared between the two groups. Results After treatment, the VAS of the observation group was lower than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the levels of IL-6, TNF-α and CRP of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). There were no statistically significant differences in the incidence rates of adverse reactions such as infection, edema, wound pain and secondary bleeding between the two groups (P＞0.05). Conclusion Both conventional Western medicine and Zijin Xiaozhong Lotion are effective in the treatment of hemorrhoid pain, but Zijin Xiaozhong Lotion has more obvious inhibitory effect on pain, rapid improvement of inflammatory factors, higher safety and significant clinical application value. 2021 Vol. 28 (19): 177-179 [Abstract] ( 45 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 180 Clinical Effect of Lingxi Yin combined with Metoprolol Tartrate in the treatment of coronary heart disease complicated with arrhythmia WU Zi-qiang ZHOU Ying Objective To study the clinical effect of Lingxi Yin combined with Metoprolol Tartrate in the treatment of coronary heart disease complicated with arrhythmia. Methods A total of 70 patients with coronary heart disease and arrhythmia who were admitted to Shaoguan Traditional Chinese Medicine Hospital from October 2019 to October 2020 were selected as the research objects. They were divided into the control group and the observation group using the random number table method, with 35 cases in each group. Patients in the control group were treated with basic medications for coronary heart disease combined with oral Metoprolol Tartrate, and patients in the observation group were treated with Lingxi Yin orally on the basis of the treatment of the control group. Both groups were treated for 10 days,the comprehensive clinical efficacy, the number of atrial and ventricular premature beats, heart rate, and QT dispersion(QTD) before and after treatment were compared between the two groups. Results The total effective rate of treatment in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05).After treatment, the number of atrial and ventricular premature beats on the Holter in both groups was fewer than that before treatment, and that in the observation group was fewer than that in the control group, the heart rate and QTD of the two groups after treatment were lower than those before treatment, and those in the observation group were lower than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Lingxi Yin combined with Metoprolol Tartrate can significantly improve the effect of coronary heart disease complicated with arrhythmia. 2021 Vol. 28 (19): 180-183 [Abstract] ( 39 ) HTML (40 KB)  PDF  (0 KB)  ( 8 ) 184 Clinical study of internal and external treatment of traditional Chinese medicine for chronic cough variant asthma LI Hui-yi1 ZHAO Li-shuang2 ZHOU Cheng-zhang3 Objective To investigate the clinical effect of internal combined with external treatment of traditional Chinese medicine on the chronic cough variant asthma (CVA). Methods From September 2018 to September 2019, 97 CVA patients admitted to Dehui Hospital of Traditional Chinese Medicine were selected as the research objectes. They were randomly divided into the reference group (48 cases) and the experimental group (49 cases) by lotting. Patients in reference group were treated with bronchiectasis, Montelukast Sodium and other routine Western medicine treatment.On the basis of the reference group, the patients in the experimental group were treated with internal combined with external treatment of traditional Chinese medicine by the introduction of electrical pulse and Maxing Shigan Decoction.Three months later, the clinical efficacy, serum immunoglobulin E (IgE), interleukin-13 (IL-13) and eosinophil count(EOS) were compared between the two groups. Results The total effective rate of treatment in the experimental group was higher than that in the reference group, and the difference was statistically significant (P＜0.05). There were no significant differences in IgE, IL-13 and EOS before treatment between the two groups (P＞0.05). After treatment, the IgE,IL-13 and EOS of the two groups were lower than those before treatment, and the differences were statistically significant (P＜0.05). After treatment, the IgE, IL-13 and EOS of the experimental group were lower than those of the reference group, and the differences were statistically significant (P＜0.05). Conclusion On the basis of Western medicine treatment, the treatment of chronic CVA patients with traditional Chinese medicine by direct current plasma introduction and Maxing Shigan Decoction can improve anti-allergic inflammation and improve clinical efficacy. 2021 Vol. 28 (19): 184-186 [Abstract] ( 40 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 187 Analysis of the causes and countermeasures of pneumoconiosis patients lost in follow-up survey HU Na LU Jian-guo LI Ye XUE Lai-jun▲ Objective To analyze the telephone follow-up of pneumoconiosis patients and the causes of lost follow-up,and put forward the corresponding countermeasures. Methods A retrospective survey of 471 pneumoconiosis patients reported in Qingyuan City since the founding of People′s Republic of China (October 1949) to December 2019 was conducted by telephone, letter or door-to-door follow-up to understand the death, survival and work-related injury insurance benefits of pneumoconiosis patients. Results From the founding of People′s Republic of China to the end of 2019, a total of 471 cases of occupational pneumoconiosis were reported in Qingyuan City, among them, 311 cases died, accounting for 66.03% of the total cases, and 126 cases of existing pneumoconiosis cases, accounting for 26.75%of the total cases in Qingyuan. After four rounds of follow-up survey, the lost follow-up rate decreased round by round,which were 84.93%, 59.45%, 7.86% and 7.64% respectively. The main reasons for the loss of follow-up were lack of pneumoconiosis card, incomplete basic information, wrong ID card information, no corresponding person according to the date of birth, wrong telephone number, no response, power off, shutdown, obtaining the death from other ways, but unable to obtain the time of death, etc. Conclusion The lost follow-up rate of occupational pneumoconiosis in Qingyuan City is 7.64%. It is necessary to strengthen the health education and file management of pneumoconiosis patients, improve the information system, improve the standardization of follow-up process, and reduce the loss of follow-up rate. 2021 Vol. 28 (19): 187-190 [Abstract] ( 56 ) HTML (34 KB)  PDF  (0 KB)  ( 8 ) 191 Analysis on the data of children′s health care aged 0-3 in a certain community in Jiading from 2018 to 2020 ZHAO Qian Objective To analyze the health care related indicators of children aged 0-3 years within the jurisdiction area, to understand the growth law of children, and to provide better basis for children′s health care. Methods Data of 9 physical examination of children aged 0-3 from January 1, 2018 to December 31, 2020 were extracted from Shanghai community health service information system. SPSS 22.0 statistical software and Excel 2007 were used to analyze the data. Results There was no significant difference in children′s weight at all physical examination stages from 2018 to 2020 (P＞0.05), and there was significant difference in the height at 12 and 30 months from 2018 to 2020 (P＜0.05).With the increase of months, the height and weight of children showed an upward trend. There were no significant differences among the detection rates of heat-protein malnutrition, simple obesity and growth retardation from 2018 to 2020 (P＞0.05), while the detection rates of nutritional iron deficiency anemia were significantly different from 2018 to 2020 (P＜0.05). Conclusion The overall level of the weight and height of children aged 0-3 within a community of Jiading are stable and conform to the laws of growth and development from 2018 to 2020, but the standard of health care of children still needs to be improved for reducing the prevalence of common nutritional diseases in children. 2021 Vol. 28 (19): 191-193转197 [Abstract] ( 38 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 194 Characteristics of suicide in elderly over 60 years old in Zhongshan City DENG Lan-fang WAN Jing HUANG Cai-ying ZHANG Jie▲ DU Bao-guo Objective To analyse the characteristics of elderly suicides in Zhongshan City. Methods Cases whose age of death was 60 years or older, time of death was between January 1, 2015 and December 31, 2017 and “ICD code of Underlying cause of death” X60-X84 were selected from the Cause of Death Registration Reporting Information System. According to the major and minor suicide methods, the cases were divided into two groups: the hanging group and the non-hanging group. The characteristics of demographic data, place of death and suicide methods were compared between the two groups. Results From 2015 to 2017, there were 79 cases of suicides aged above 60 years old in Zhongshan City with an average age of (71.22±8.88) years old, most of the place of death was at home [60.76% (48/79)], and most of them were hanged [63.29% (50/79)]. The age of hanging was higher than that of other suicide methods(P＜0.05).Percentage of death at home in the hanging group was higher than that of non-constricted group (P＜0.05). Conclusion The suicides of the elderly in Zhongshan City are relatively old, and most of the suicides occur at home. The suicide methods are mainly by hanging, and it is urgent to further study the intervention strategies for specific suicide methods such as hanging. 2021 Vol. 28 (19): 194-197 [Abstract] ( 44 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 198 Analysis of prevalence and clinical manifestations of forest encephalitis in Yanbian area CHEN Ning Objective To judge the epidemiological characteristics and population distribution of patients in recent years through 209 patients registered from Yanbian University Hospital with definite diagnosis of forest encephalitis from 2012 to 2018, and the epidemiology, prognosis and treatment of the patients were recorded. Methods A total of 209 patients with forest encephalitis from 2012 to 2018 registered and reported in Yanbian University Hospital were selected, and their age, gender, occupation, region, onset time, condition at admission, routine examination of brain crest fluid and prognosis of the patients were recorded. Excel software was used to make the data into charts for analysis and comparison. Results There were 209 cases of forest encephalitis, and the time distribution showed a decreasing trend from 2012 to 2018. The distribution of forest encephalitis was still dominated by the Changbai mountain and forest region. That was dominated by the Han nationality, followed by the Korean nationality. The male and female ratio showed that male was more than female, 1.77∶1. The age distribution was between over 40 and 60 years old. The majority of the patients was mild cases, but the death, uncured, and discharge were concentrated in the critically ill patients.The abnormality of cerebrospinal fluid was 77.1%, but there were still a considerable proportion of patients with normal cerebrospinal fluid at the initial stage, particularly, 3.6% was severe patients. Conclusion The incidence of forest encephalitis is decreasing year by year in Yanbian area. But there is still a lack of effective diagnosis and specific treatment. 2021 Vol. 28 (19): 198-200 [Abstract] ( 35 ) HTML (31 KB)  PDF  (0 KB)  ( 8 ) 201 Investigation and research on practice environment of nursing staff based on magnetic hospital management concept DOU Dao-qin Objective To provide a reference basis to continue to improve the nurse′s practice environment by investigating the nursing practice environment in Bao′an People′s Hospital of Shenzhen City based on analysis of magnetic hospital management concept. Methods A total of 350 nurses from the Second Affiliated Hospital of Shenzhen University from September 1 to 30, 2020 were selected as the research subjects. The Nurse Practice Environment Assessment Scale questionnaire was used for the survey. The questionnaire covered demographic data and the content of the practice environment of nurses, and the latter included six dimensions of “nursing staff participating in hospital affairs”“basis of high-quality nursing service”“capability, leadership and support of nursing managers”“manpower and material resources”“cooperation between physician and nurse” and “salary and social status”. The working environment of nursing staff was understood and its influencing factors were analyzed. Results A total of 302 valid questionnaires were collected.The overall score of nursing staff′s practice environment was (71.37±11.24)points, among which the item “manpower and material resources” had the highest score of (77.82±19.97) points, and the item “nurses participating in hospital affairs” had a lower score of (54.11±17.08) points. Multiple regression analysis showed that the different characteristics of nursing staff such as department, professional title, education background and whether they were in the department or not, had an impact on the evaluation of nursing′ practice environment (P＜0.05). Conclusion The overall score of the nurses′ practice environment assessment in this hospital is lower. The hospital should introduce the concept of magnetic hospital management, adhere to the people-centered approach, continuously optimize and improve the salary and benefits distribution system, provide more opportunities for nursing staff education, title promotion and career planning, and ameliorate the practice environment of nursing staff . 2021 Vol. 28 (19): 201-204 [Abstract] ( 36 ) HTML (35 KB)  PDF  (0 KB)  ( 8 ) 205 Application effect of flipped classroom teaching mode based on medical popular science video ShenDu-Video in geriatrics course teaching ZHU Lin SHAO Cen ZHANG Ying Objective To explore the application effect of flipped classroom teaching mode based on medical popular science video ShenDu-Video in geriatrics course teaching. Methods A total of 247 students from the 2018 clinical class of Jiangxi Medical College were selected as the research objects and divided into the experimental group (125 students) and the control group (122 students) according to class. The experimental group adopted the flipped classroom teaching mode based on ShenDu-Video, while the control group adopted the traditional teaching mode. The theory test scores of the two groups and the students′ satisfaction of the experimental group were compared. Results The scores of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The proportion of students in the experimental group who approved all aspects of the flipped classroom teaching mode based on ShenDu-Video were higher than the proportion of students who did not approve. Conclusion The flipped classroom teaching model based on ShenDu-Video is applied to geriatric medicine teaching, which can improve students′ theoretical performance, interest and ability in learning. 2021 Vol. 28 (19): 205-208 [Abstract] ( 31 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 209 Effect of systematic health education on cognitive level and self-care ability of patients with viral hepatitis B cirrhosis XU Mei-zhen1 LIU Bin2 Objective To explore the effect of systematic health education on the cognitive level and self-care ability of patients with hepatitis B liver cirrhosis. Methods A total of 102 patients with viral hepatitis B cirrhosis who were treated in Chaisang District Schistosomiasis Control Station and Chaisang District People′s Hospital of Jiujiang City from July 2017 to July 2020 were selected as the research subjects. According to random number table method, they were divided into control group and observation group, with 51 patients in each group. The control group was given routine nursing intervention, while the observation group was given systematic health education intervention on the basis of the control group. The cognitive level of patients (including the knowledge of disease, treatment, medication knowledge and life management), self nursing ability (including self concept and self care skills, sense of responsibility and self health knowledge level) and the treatment compliance behavior (including proper dose on time, reasonable exercise, science,healthy eating, actively cooperate with treatment and periodically review) were compared between two groups. Results After intervention, the cognitive level and self-care ability scores of the two groups were higher than those before intervention, and the cognitive level and self-care ability scores of the observation group were higher than those of the control group after intervention, the differences were statistically significant (P＜0.05). The treatment compliance of the observation group was higher than that of the control group in all aspects, the differences were statistically significant (P＜0.05). Conclusion Systematic health education for patients with viral hepatitis B cirrhosis can effectively improve patients′ cognitive level of disease and health knowledge, enhance the ability of self-care, improve treatment compliance behavior, and further ensure the treatment effect, which is worthy of clinical promotion. 2021 Vol. 28 (19): 209-212 [Abstract] ( 41 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 213 Application of situational simulation teaching method in preclinical education of oral medicine ZHAO Chen ZHOU Yue LI Yu-ting ZHENG Sai-wei TAN Zheng-wu HE Yuan▲ Objective To investigate the application effect of situational simulation teaching method in preclinical education of oral medicine. Methods A total of 30 first-year graduate students enrolled in 2018 in the Affiliated Stomatology Hospital of Tongji University and the students who participated in the standardized training of resident doctors in 2018 in the Affiliated Stomatology Hospital of Tongji University (all of them were fresh graduated from stomatological schools of colleges and universities) were selected as the research objects. From August to December 2018, the students participated in the scenario simulation teaching project. From July to September 2019, students were evaluated after 3 months of internship in the oral medicine system. Students′ academic and technical achievements, complaints before and after teaching and teaching satisfaction were compared. Results The scores of theory and skills of students after scenario simulation teaching were higher than those before teaching, the differences were statistically significant (P＜0.05). The survey results showed that students′ satisfaction with all aspects of situational simulation teaching was high.After situational simulation teaching, the proportion of patients who complained was lower than that of students who had not received situational simulation teaching within 3 months before entering the clinical practice of stomatology department, the difference was statistically significant (P＜0.05). Conclusion The application of situational simulation teaching method in pre-clinical teaching of oral medicine can improve students′ communication ability and medical record analysis ability to a certain extent, which is helpful to reduce doctor-patient disputes, and is worthy of further research and promotion. 2021 Vol. 28 (19): 213-216 [Abstract] ( 33 ) HTML (37 KB)  PDF  (0 KB)  ( 8 ) 217 Application analysis of online teaching optimization strategies during the corona virus disease 2019 epidemic GAO Ya LI Nan-nan▲  With the development of information technology, online teaching has gradually been brought into the limelight. The rise of the extensive opening of online courses since 2012 promoted education equity, with more and more online teaching platforms emerging. Due to the widespread of the corona virus disease 2019 (COVID-19), the dates of matriculation had to be postponed. A wide array of categories and levels of schools launched programs of online teaching one after another, in a positive response to "suspending school but not learning", a call by the ministry of education. While online teaching highlights its necessity during this pandemic, it reveals some issues that make the online course fail to meet the expectation of the communication effects, especially for the medical majors. Drawing on the expertise of communication studies, this paper starts with four facets of the issue: disseminator, text, institution, and audience, proposing optimization strategies, including updating the disseminator′s infrastructures of "hardware" and "software", adjusting the content of online teaching, optimizing and upgrading the systems of the platforms of online teaching, and cultivating a disciplined learning habit of the students. This paper eventually seeks to explore the pathways to optimizing the communication effects of online teaching and to enlightening the future online teaching. 2021 Vol. 28 (19): 217-220 [Abstract] ( 34 ) HTML (37 KB)  PDF  (0 KB)  ( 9 ) 221 Study on effect of programmed health education on anxiety and postoperative pain of patients undergoing general surgery HU Bo ZHANG Cui-lv YANG Fan Objective To explore the effect of programmed health education on anxiety, postoperative pain and satisfaction of patients undergoing general surgery. Methods From June 2019 to November 2020, 52 patients in the Department of General Surgery of the First People′s Hospital of Ji′an City were selected as the research objects and divided into the observation group and the control group according to the single and even number method, with 26 cases in each group. The control group was given routine nursing, and the observation group was given programmed health education on the basis of the control group. The anxiety, pain and satisfaction were compared between the two groups. Results After intervention, the Hamilton anxiety scale (HAMA) score and McGill pain score in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The total nursing satisfaction of the observation group (100.00%) was higher than that of the control group (76.92%), and the difference was statistically significant (P＜0.05). Conclusion The implementation of programmed health education in patients with general surgery can significantly alleviate or eliminate the anxiety of patients, improve the pain of surgical treatment, and improve the nursing satisfaction of patients. 2021 Vol. 28 (19): 221-223 [Abstract] ( 44 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 224 Application of quality control circle combined with problem-based learning in nurse teaching of Neurology Department CHEN Xiu-min LIN Xi-rong GUO Deng-bin LUO Jing-yi▲ Objective To analyze the application effect of quality control circle combined with problem-based learning(PBL) mode in nurse teaching of Neurology Department. Methods A total of 50 cases of neurology nursing intern students from Mindong Hospital Affiliated to Fujian Medical University from September to December 2019 were selected as the research objects. According to the random number table method, the nursing students were divided into the control group and the observation group, with 25 cases in each group. The control group adopted the conventional teaching mode, and the observation group was given the quality control circle combined with PBL. Assessment of performance,comprehensive ability and satisfaction with nursing measures were compared between the two groups. Results The results of basic theoretical knowledge, nursing skills, operation ability and self-ability in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The scores of participation,problem-solving ability, communication and coordination, teamwork spirit and activity confidence in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The total satisfaction of students in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of quality control circle combined with PBL teaching mode in the teaching of neurology nurses can improve the comprehensive ability of nursing students and help improve the quality of teaching. 2021 Vol. 28 (19): 224-226转230 [Abstract] ( 46 ) HTML (33 KB)  PDF  (0 KB)  ( 6 ) 227 Spinal dural arteriovenous fistula: a case report and literature review YAO Ben-hai1 LIU Hai-jun2 ZENG You-chao1 ZUO Hao1 PAN Yong-jie1 ZHAN Jian1▲ In this article, 1 Spinal dural arteriovenous fistula was reported. The onset signs of SDAVF include lower limb weakness, urination and defecation difficulties, and sensory disturbance. With atypical early clinical symptoms in most cases, it is susceptible to clinical underdiagnosis or misdiagnosis. The reported case was found with past medical history of cerebral hemorrhage, whose condition improved after medical treatment, but still had right limb weakness.Before August, he was found with the weakness in both lower limbs, local hospital considered the recurrence of cerebrovascular disease, but didn′t check up spinal cord, which led to the early misdiagnosis. At the Second Affiliated Hospital of Zunyi Medical University, this case was identified with spinal cord lesions and spinal vascular malformation by spinal cord MRI examination in consideration of the condition. The general consideration of clinical l symptoms, signs and spinal cord imaging findings led to the definitive diagnosis of SDAVF. The report and literature review of the case is expected to provide an insight into SDAVF and improve the ability of doctors to treat the disease. 2021 Vol. 28 (19): 227-230 [Abstract] ( 34 ) HTML (30 KB)  PDF  (0 KB)  ( 7 ) 231 Analysis of drug regimen of one patient after valve replacement FENG Jia-yuan Anticoagulant therapy after heart valve replacement is of great clinical significance, and reasonable anticoagulant therapy is also of great significance for improving the long-term prognosis of patients with atrial fibrillation.The case recorded in this paper was a patient with atrial fibrillation after mechanical heart valve replacement, which has a higher risk of thromboembolism. Therefore, individualized anticoagulant therapy is particularly important. This article through the whole process of drug therapy for patients with monitoring, combining with the condition changes and clinical therapeutic effect of anticoagulant drugs, antibacterial and adjust heart failure treatment, eventually making treatment plan for patients, improve the practice ability of clinical pharmacists, and patients long-term effective and safe drug treatment is slow. 2021 Vol. 28 (19): 231-234 [Abstract] ( 48 ) HTML (33 KB)  PDF  (0 KB)  ( 7 ) 235 Comparison of two disinfection methods of needleless infusion connector WEN Wen TONG Li-ling▲ WU Dan Objective To compare the effect of two disinfection methods of the needleless infusion connector. Methods Twenty-six clinical nurses in Haikou Hospital Affiliated to Xiangya Medical College of Central South University from January to March 2019 were selected as the research subjects, and all the 26 nurses participated in the control group and the observation group. The 0.2% Entoiodine cotton swabs were used by nurses in the control group to disinfect the needleless infusion connectors for 150 times, and the individually wrapped 4 cm×4 cm 75% alcohol cotton pads were used by nurses in the observation group to disinfect the needleless infusion connectors for 150 times. The disinfection operation time and use time of needleless infusion connectors, consumables costs, re-contamination after disinfection,clinical nurses′ satisfaction and willingness degrees were compared between the two groups. Results The proportions of non-contamination after disinfection and re-contamination after disinfection in the control group and the observation group were 88.0%, 12.0%, 94.0% and 6.0%, respectively. The proportion of non-contamination after disinfection in the observation group was higher than that in the control group, and the difference was statistically significant (P＜0.05). The consumables cost and disinfection operation time of the control group and the observation group were(61.6±1.62) yuan and (36±3) s，and (37.8±0.82) yuan and (16±1) s, respectively. The consumables cost of the observation group was lower than that of the control group, and the disinfection operation time of the observation group was shorter than that of the control group, the differences were statistically significant (P ＜0.05). The degrees of satisfaction and willingness of nurses in the control group and the observation group were 46.0%, 46.0%, 92.0% and 92.0% respectively. The degrees of satisfaction and willingness of nurses in the observation group were higher than those of nurses in the control group, and the differences were statistically significant (P＜0.05). Conclusion Using the 4 cm×4 cm 75% alcohol cotton pad to maintain the needleless infusion connector is convenient for nurses to disinfect the connector grooves with the rubbing method and effectively remove the residual microorganisms in the connector grooves. It can also shorten the disinfection operation time, save the consumables cost, effectively reduce the recontamination rate after the disinfection of needleless infusion connectors, and improve the satisfaction and willingness of clinical nurses, which is worthy of clinical promotion and application. 2021 Vol. 28 (19): 235-237 [Abstract] ( 43 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 238 Application study of clinical nursing pathway in perioperative nursing of Standford B type thoracic endovascular aortic repair YAN Yi-ping ZHENG Chun-yan▲ ZHANG Na YANG Yu-jin ZHANG Jia CAI Xiao-ling Objective To explore the effect of clinical nursing pathway in the perioperative nursing of Standford B type thoracic endovascular aortic repair (TEVAR). Methods A total of 60 patients with Stanford B type aortic dissection admitted to the Department of Vascular Surgery of the Second Affiliated Hospital of Nanchang University from January to October 2020 were selected as the research objects and divided into the control group (30 cases) and the experimental group (30 cases). The control group was given routine nursing care, the experimental group adopted routine nursing clinical nursing path method. The incidence of complications, rate of health education, length of stay, cost of hospitalization and satisfaction of nursing work were compared between the two groups. Results The total rate of complications in the experimental group was lower than that in the control group, and the rate of reaching the standard of health education was higher than that in the control group, the differences were statistically significant (P＜0.05). The hospitalization time of the experimental group was shorter than that of the control group, and the hospitalization expense of the experimental group was less than that of the control group, the differences were statistically significant (P＜0.05). The nursing job satisfaction of the experimental group was higher than that of the control group, the difference was statistically significant (P ＜0.05). Conclusion The application of clinical nursing pathway in the perioperative nursing of Standford B type TEVAR can significantly reduce the complications, improve the rate of health education, shorten the length of stay, reduce the cost of hospitalization, improve patient satisfaction. 2021 Vol. 28 (19): 238-240转245 [Abstract] ( 53 ) HTML (1 KB)  PDF  (0 KB)  ( 10 ) 241 Application of personalized high quality nursing intervention in magnetic resonance imaging QIU Zhi-min DING Chang-qing LIU Wei YUAN Yan-ju ZHANG Ya-ping ZHU Min Objective To explore the application effect of personalized high-quality nursing intervention in magnetic resonance imaging (MRI) examination. Methods A total of 200 patients undergoing MRI examination in Nantong University Affiliated Fengxian Hospital from September to October 2020 were selected and divided into the control group(n=100) and the experimental group (n=100) according to the random number table method. Patients in the control group were given conventional nursing measures, and patients in the experimental group were given personalized highquality nursing intervention mode on the basis of the control group. The scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) before and after examination were compared between the two groups, and the examination times, excellent and good rates of MRI image quality, nursing satisfactions and the incidence of nursing risk events were compared between the two groups. Results After intervention, SAS and SDS scores of the experimental group were lower than those of the control group, and the examination time of the experimental group was shorter than that of the control group, and the differences were statistically significant (P＜0.05). The excellent and good rate of MRI image quality and nursing satisfaction of the experimental group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The incidence of nursing risk events in the experimental group was lower than that in the control group, and the difference was statistically significant (P＜0.05). Conclusion Personalized high quality nursing intervention can significantly improve patients′ negative emotions, shorten examination time, improve image quality and nursing satisfaction, and reduce the incidence of nursing risk events. 2021 Vol. 28 (19): 241-245 [Abstract] ( 39 ) HTML (40 KB)  PDF  (0 KB)  ( 7 ) 246 Application effect of swallowing function training combined with accelerated rehabilitation surgery in patients with swallowing dysfunction after oral cancer surgery CHEN Sai-quan FANG Hui-ping Objective To investigate the application effect of swallowing function training combined with accelerated rehabilitation surgery in patients with swallowing dysfunction after oral cancer surgery. Methods The clinical data of 60 patients with oral cancer treated in Jiujiang First People′s Hospital were retrospectively analyzed. A total of 30 patients who were admitted from January to June 2018 were included in the control group and given routine nursing. Another 30 patients who were admitted from July 2018 to May 2019 were included in the experimental group and given swallowing function training combined with accelerated rehabilitation surgical nursing. The postoperative recovery status(the first time of getting out of bed, the length of hospital stay, the decrease of body weight 7 days after surgery), the treatment cost and the incidence of complications were compared between the two groups. The swallowing function of the patients was evaluated by standard swallowing function scale (SSA) on the 1, 7 and 14th day after surgery. The visual analogue scale (VAS) was used to evaluate the pain degrees of the 2 groups at 12, 24 and 48 h after surgery, respectively. Results On day 7 and 14 after surgery, SSA scores of patients in both groups were lower than those on day 1 after surgery, and SSA scores of the experimental group on day 7 and 14 after surgery were lower than those of the control group, with statistical differences (P＜0.05). VAS scores at 24 and 48 h after surgery in the two groups were lower than those at 12 h after surgery, VAS scores of the experimental group at 12, 24 and 48 h after surgery were lower than those of the control group, and the differences were statistically significant (P＜0.05). Compared with the control group, in the experimental group, the first postoperative time of getting out of bed and hospitalization time were shorter;the decrease of body weight was lower; the treatment cost was lower, and the differences were statistically significant(P＜0.05). The total incidence of complications of the experimental group was 3.33%, which was lower than that of the control group (20.00%), and the difference was statistically significant (P＜0.05). Conclusion Early swallowing function training and accelerated rehabilitation surgical care for patients with swallowing dysfunction after oral cancer surgery can effectively promote the recovery of swallowing function, reduce the occurrence of complications, relieve the pain of patients, shorten the postoperative recovery time and hospitalization time, and help to reduce their economic burden. 2021 Vol. 28 (19): 246-249 [Abstract] ( 42 ) HTML (35 KB)  PDF  (0 KB)  ( 7 ) 250 Effect of graphene infrared ray combined with traditional Chinese medicine package for fistula nursing hot compress device on autologous arteriovenous fistula in hemodialysis patients WANG Li1 WANG Lu1 LIU Ling2 XU Qian3 CHEN San-e4 RAO Jun5 Objective To investigate the effect of graphene infrared ray combined with traditional Chinese medicine package for fistula nursing hot compress device on autologous arteriovenous fistula (AVF) in hemodialysis patients.Methods Sixty patients using autologous AVF for hemodialysis who were admitted to Shangrao People′s Hospital from March 2019 to March 2020 were selected and divided into the control group (30 cases) and the observation group (30 cases) according to the random number table method. The control group was given routine nursing, and the observation group was given graphene infrared ray combined with traditional Chinese medicine package for fistula nursing hot compress device nursing for 6 months. AVF maturation was compared between the two groups before nursing, after nursing for 1, 3 and 6 months. The degree of puncture pain (visual analogue scale [VAS])in different periods was also observed between the two groups. Results After nursing for 1, 3 and 6 months, the vascular inner diameters and blood flows in the observation group were greater than those in the control group, and the vascular sclerosis areas were smaller than those in the control group, with statistically significant differences (P＜0.05).VAS scores in the observation group after 1, 3 and 6 months of nursing were lower than those in the control group, with statistically significant differences (P ＜0.05). Conclusion Graphene infrared ray combined with traditional Chinese medicine package for fistula nursing hot compress device can effectively improve the vascular diameter of autologous AVF in hemodialysis patients, improve the blood flow of hemodialysis patients, reduce the area of vascular sclerosis, and relieve the pain of hemodialysis. 2021 Vol. 28 (19): 250-252转256 [Abstract] ( 41 ) HTML (31 KB)  PDF  (0 KB)  ( 6 ) 253 Effect of midwife′s psychological nursing combined with dietary intervention on the delivery mode of scarred uterus WANG Can-hui LUO Li-qiong▲ LIU Zheng ZHAO Li-sha HUANG Cui-lian ZENG Zhi-min Objective To analyze the effect of midwife′s psychological nursing combined with dietary intervention on the delivery mode of scarred uterus women. Methods A total of 600 cases of maternal patients with scar uterus admitted to the People′s Hospital of Lenghua District, Shenzhen from January 2018 to October 2020 were selectedas the research objects, they were divided into observation group (30 cases) and control group (30 cases), The control group adopted the dietary intervention method, the observation group adopted the psychological nursing on the basis of the control group. The two groups were compared in terms of birth outcomes, optimistic levels, self-rating anxiety scale(SAS) and self-rating depression scale (SDS) scores. Results Both vaginal trial production and success rate (90.0%,51.85%) in the observation group were higher than those in the control group (53.33%, 18.75%), the difference was statistically significant (P＜0.05). The optimistic level in the observation group was higher than that in the control group,the SAS, SDS scores were lower than those in the control group (P＜0.05). Conclusion Dietary intervention combined with psychological nursing of midwives can increase vaginal delivery rate and have some clinical significance. 2021 Vol. 28 (19): 253-256 [Abstract] ( 42 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 257 Influence of communication skills and predictive nursing on self nursing ability of hemodialysis patients CHEN Hua-mei Objective To explore the influence of communication skills and predictive nursing on self-care ability of hemodialysis (HD) patients. Methods A total of 80 cases of HD patients in Fuzhou First People′s Hospital, Jiangxi Province from May 2018 to April 2020 were selected as study objects, and were divided into two groups according to the odd and even method, 40 cases in each group. The odd number was the control group, routine nursing was given;the even number was the experimental group, communication skills combined with predictive nursing was given. The exercise of self-care agency (ESCA), health survey scale (SF-36) score before and after nursing, nursing satisfaction score and the incidence of adverse events and adverse reactions were compared between the two groups. Results There were no significant differences in the scores of ESCA and SF-36 between the two groups before nursing (P＞0.05); after nursing, the scores of ESCA and SF-6 in the experimental group were higher than those in the control group, the differences were statistically significant (P＜0.05); the score of nursing satisfaction in the experimental group was higher than that in the control group, the incidence of adverse events in the experimental group was 5.0%, lower than 22.5%in the control group, and the incidence of adverse reactions in the experimental group was 2.50%, lower than 20.5% in the control group, the difference were statistically significant (P＜0.05). Conclusion Communication skills and predictive nursing have a significant effect in self-care ability of HD patients, which can significantly improve the self-care ability of patients, reduce the incidence of adverse reactions and adverse events, improve the safety and quality of life, and obtain more recognition and love of patients, which is worthy of clinical implementation. 2021 Vol. 28 (19): 257-259 [Abstract] ( 42 ) HTML (30 KB)  PDF  (0 KB)  ( 6 ) 260 Application of nursing intervention based on chronic disease trajectory model in hemodialysis patients YAN Bi-yan LIANG Cui-yun MAI Cui-fang YAO Rong Objective To explore the application effect of nursing intervention based on chronic disease locus model in hemodialysis (HD) patients. Methods A total of 120 patients with end-stage renal disease who underwent HD in Nanhai Fourth People′s Hospital of Foshan from July 2019 to June 2020 were selected and divided into the control group and the observation group according to random number table method, 60 cases in each group. The control group was given routine nursing, and the observation group was given nursing intervention based on chronic disease track mode;the changes of anxiety, depression, coping style and quality of life of the two groups before and after intervention were compared. Results Before the intervention, there were no significant differences in the scores of anxiety, depression,coping style and quality of life between the two groups (P＞0.05). After the intervention, the scores of anxiety, depression, avoidance dimension and yield dimension of the two groups were lower than those before the intervention, except for the physiological function dimension of the quality of life of the control group, the scores of the face dimension and other dimensions of the quality of life of the two groups were higher than those before the intervention, the differences were statistically significant (P＜0.05). After the intervention, the scores of anxiety, depression, avoidance and yield in the observation group were lower than those in the control group, while the scores of face dimension and quality of life in the observation group were higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion The nursing intervention based on chronic disease trajectory model can significantly alleviate the anxiety and depression of HD patients, promote the patients to actively deal with the disease and treatment, and improve the quality of life. 2021 Vol. 28 (19): 260-263 [Abstract] ( 47 ) HTML (36 KB)  PDF  (0 KB)  ( 6 ) 264 Application of clinical nursing path in pediatric transfusion nursing HU Lin Objective To explore the application effect of clinical nursing path in pediatric transfusion nursing. Methods A total of 70 children requiring intravenous transfusion admitted to Shenyang Children′s Hospital, Liaoning Province from February 2018 to February 2019 were selected as the research subjects, and they were divided into the control group (35 cases） and the observation group （35 cases） according to a random number table method. In the control group, traditional transfusion nursing intervention was carried out, and in the observation group, clinical nursing path intervention on the basis of the control was implemented. The children′s transfusion compliance, transfusion residual amount, success rate of puncturing once, pain and nursing satisfaction were compared in the two groups. Results The incidence of active cooperation and participation in the observation group was higher than that of the control group, and the incidence of resistance and strong resistance was lower than that of the control group, the differences were statistically significant (P＜0.05). The residual amount of transfusion in the observation group was less than that in the control group, the success rate of puncturing once in the observation group was 94.29%, higher than that in the control group accounting for 80.00%, the differences were statistically significant (P＜0.05). The pain score of the observation group was lower than that of the control group, the nursing total satisfaction of the observation group was 100.00%, higher than that of the control group accounting for 82.86%, the differences were statistically significant (P＜0.05). Conclusion In pediatric transfusion nursing, the intervention of clinical nursing path is effective. 2021 Vol. 28 (19): 264-266 [Abstract] ( 45 ) HTML (30 KB)  PDF  (0 KB)  ( 8 ) 267 Application effect of Internet+Nursing diversified service under the management of the medical group on promoting exclusive breastfeeding LIU Xing-zhen1 HUANG Xiao-yan2 LONG Pei-xian3 LIU Cai-yun1 Objective To explore the effect of Internet+Nursing service practice in promoting exclusive breastfeeding under the management of medical group. Methods A total of 198 cases of puerpera who were admitted to the Second People′s Hospital of Baiyun-Guangzhou from April to October in 2020 were selected as the research objects. According to random number table method, they were divided into control group (99 cases) and observation group (99 cases). The control group was given routine breastfeeding education. The observation group was given Internet + Nursing diversified services under the management of the medical group on the basis of conventional health education. The rates of exclusive breastfeeding on 42 and 180 d postpartum, the time of lactating and the amount of breastfeeding, the knowledge,skills and compliance of postpartum feeding were compared between the two groups. Results The exclusive breastfeeding rate of observation group was higher than that of control group on 42 and 180 d postpartum, and the difference was statistically significant (P＜0.05). The observation group had shorter postpartum lactating time than the control group,and the amount of breast milk per time was higher than the control group, the differences were statistically significant(P＜0.05). The scores of feeding knowledge, skills and feeding compliance in the observation group were higher than those in the control group after intervention, and the differences were statistically significant (P＜0.05). Conclusion The Internet+Nursing service practice under the management of medical group can improve the puerperal breastfeeding rate of 42 and 180 d postpartum, shorten the time of postpartum breastfeeding, improve the amount of breast milk per time,postpartum feeding knowledge, skills and feeding compliance, which is worthy of popularization and application. 2021 Vol. 28 (19): 267-269转273 [Abstract] ( 37 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 270 Application of comprehensive nursing intervention in patients with hysteromyoma undergoing laparoscopic resection TIAN Xiao-yu Objective To approach comprehensive nursing intervention in patients with hysteromyoma undergoing laparoscopic resection. Methods A total of 80 cases laparoscopic resection patients in Northern Theater Command General Hospital from September 2018 to September 2020 were selected as research objects, who were divided into two groups by random number table method, 40 cases in each group. The control group used routine nursing, the comprehensive nursing intervention group used comprehensive nursing intervention, the postoperative bowel sound time, selfventing time, defecation time, recovery time, life quality, self esteem level evaluation, anxiety, depression before nursing and after nursing of two groups were compared. Results The rumbling sound time, self-venting time, defecation time,diet recovery time of comprehensive nursing intervention group were shorter than those of the control group, the differences were statistical significance (P＜0.05). The life quality score, self esteem level evaluation, and anxiety, depression scores of two groups before nursing were compared, the differences were not statistically significant (P＞0.05); after nursing, the life quality score, self esteem level evaluation of two groups were higher than those before nursing, anxiety and depression scores were lower than those before nursing; the life quality score, the self esteem level evaluation of comprehensive nursing intervention group were higher than those of the control group, anxiety and depression scores were lower than those of the control group, the differences were statistically significant (P＜0.05). Conclusion The application of comprehensive nursing intervention in patients with hysteromyoma undergoing laparoscopic resection, which could improve gastrointestinal function of patients, increase life quality, self esteem level, improve anxiety and depression. 2021 Vol. 28 (19): 270-273 [Abstract] ( 26 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 274 Effect of intervention model under the guidance of multidisciplinary cooperation model in elderly patients with diabetes mellitus with acute cholecystitis ZHANG Jian-fang Objective To explore the effect of the intervention mode under the guidance of multiple disciplinary team(MDT) mode applied to elderly diabetes mellitus patients with acute cholecystitis. Methods A total of 71 elderly diabetic patients with acute cholecystitis who were admitted to Nanping People′s Hospital in Fujian Province from May 2018 to May 2020 were selected as the research objects, divided into the control group (35 cases) and the observation group (36 cases) according to the random number table method. The control group adopted conventional intervention methods, and the observation group adopted the MDT model method, the psychological status, blood sugar level and complications of the two groups were compared. Results After the intervention, the self-rating depression scale (SDS)and the self-rating anxiety scale (SAS) scores of the observation group were lower than those of the control group, and the differences were statistically significant (P＜0.05). The fasting blood glucose and 2 h postprandial blood glucose of the observation group were lower than those of the control group, the differences were statistically significant (P＜0.05).The total incidence of complications in the observation group (5.56%) was lower than that in the control group(22.86%), the difference was statistically significant (P＜0.05). Conclusion The intervention mode under the guidance of MDT mode applied to the elderly with diabetes with acute cholecystitis can control blood sugar level, improve mental state, and reduce the probability of complications. 2021 Vol. 28 (19): 274-276 [Abstract] ( 37 ) HTML (32 KB)  PDF  (0 KB)  ( 4 )

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