烟酸预防老年人冠脉介入术后造影剂肾病作用的研究

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Abstract Objective To explore the effect of Niacin on prevention of contrast-induced nephropathy (CIN) in elderly patients after coronary intervention. Methods A total of 150 elderly patients with coronary intervention admitted to Ganzhou Municipal Hospital from September 2019 to November 2020 were selected as the research objects and divided into group A, group B and group C according to random number table method, with 50 patients in each group. Group A was the blank control group, group B was treated with medium dose (40 mg) of Niacin, and group C was treated with high dose (80 mg) of Niacin. The incidence of CIN, renal function indexes, serum C-reactive protein (CRP) and superoxide dismutase (SOD) levels and the incidence of adverse events were compared among the three groups. Results The incidence of CIN in group A, B and C was 16.00% (8/50), 4.00% (2/50) and 2.00% (1/50), respectively. The incidence of CIN in group B and C was lower than that in group A, and the differences were statistically significant (P＜0.05). On postoperative day 1 and 3, the serum creatinine (SCR), blood urea nitrogen (BUN), uric acid (UA) and CRP levels in groups B and C were lower than those in group A, and the serum SOD level was higher than that in group A, and the differences were statistically significant (P＜0.05). On postoperative day 1, serum SCR and CRP levels in group C were lower than those in group B, and the differences were statistically significant (P＜0.05). The total incidence of adverse events in group A, B and C was 4.00% (2/50), 12.00% (6/50) and 28.00% (14/50), respectively. The total incidence of adverse reactions in group A was lower than that in group C, and the differences was statistically significant (P＜0.017).Conclusion Intravenous infusion of Niacin 40 mg bid 24 h before and 72 h after coronary intervention in the elderly can reduce the incidence of CIN, improve renal function,inflammatory factors and oxidative stress response after coronary intervention.

Key words： Niacin Percutaneous coronary intervention Contrast-induced nephropathy Prevention

Received: 30 December 2020

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