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Quick Search     Adv Search 2020 Vol. 27, No. 5 Published: 2020-02-18   4 Screening of mutation genes in a family with congenital cataract WANG Zhong-ying；LIU Shan-he；ZHENG Gui-qian；HAO Lin-na；HU shan-shan Objective To screen mutation in pathogenic genes in a family with congenital blue dot cataract,so as to explore their potential genetic defects.Methods A congenital blue dot cataract family in Heilongjiang province was collected in September 2017.After detailed medical history collection and clinical examination of this family and normal controls,polymerase chain reaction (PCR) sequencing was used to detect the mutation of candidate genes in cataract hot spots.Results The heterozygous missense mutation of c.10T＞C was found in the GJA8 gene of this family,which resulted in the change of the highly conserved tryptophan in the fourth position to arginine (p.W4R),but the mutation was not found in the normal members of the family or the normal controls.Conclusion The GJA8 gene c.10T＞C mutation is the potential genetic etiology of this family,which extends the GJA8 gene mutation spectrum of congenital cataract. 2020 Vol. 27 (5): 4-6转11 [Abstract] ( 93 ) HTML (38 KB)  PDF  (0 KB)  ( 10 ) 7 Comparison of different modeling methods of chronic myocardial ischemia HU Liu； WU Yan； HAN Quan； WANG Wei Objective To compare the differences and advantages between different methods of chronic myocardial ischemia.Methods Thirty male ICR mice were selected and divided into subcutaneous injection group,sustained-release pump release group and control group according to different modeling methods,with 10 rats in each group.In the subcutaneous group,Isoproterenol (ISO) 30 mg/(kg·d) was injected subcutaneously into the lumbar back of the mice for 14 days.The release pump group was placed subcutaneously in the lumbar back of the mice.The ISO release amount was 30 mg/(kg·d).The control group was injected subcutaneously with an equal dose of physiological saline.Myocardial ischemia was measured by myocardial zymogram and heart section TTC staining.Results There was no significant difference in the mortality between the subcutaneous injection group and the sustained-release pump release group (P＞0.05).The cardiac hypertrophy index of the mice in the subcutaneous injection group and the sustained-release pump release group was higher than that in the normal control group,and the difference was statistically significant (P＜0.05).There was no significant difference in the cardiac hypertrophy index between the subcutaneous injection group and the sustained-release pump release group (P＞0.05).The myocardial ischemic area of the mice in the sustained-release pump release group was higher than that of the subcutaneous injection group,and the difference was statistically significant(P＜0.05).The myocardial enzymes and cardiac troponin T (cTnT) level of the mice in the sustained-release pump release group were higher than those in the normal control group,and the differences were statistically significant (P＜0.05).The levels of α-hydroxybutyrate deoxygenase (α-HBDH),aspartate aminotransferase (AST),isozyme (mAST) and cTnT in the subcutaneous group were higher than those in the normal control group,and the differences were statistically significant (P＜0.05).While the levels of creatine kinase (CK) and isoenzyme (CK-MB) and lactate deoxygenase(LDH) in the subcutaneous group were not significantly different from those of the normal control group (P＞0.05).There was no significant difference in myocardial zymogram and cTnT between the sustained-release pump release group and the subcutaneous injection group (P＞0.05).Conclusion Both subcutaneous injection and sustained release pump release ISO can cause myocardial hypertrophy in mice,sustained release pump can induce myocardial ischemia in mice to a greater extent,and sustained release pump also causes damage to myocardial function to a greater extent. 2020 Vol. 27 (5): 7-11 [Abstract] ( 76 ) HTML (45 KB)  PDF  (0 KB)  ( 8 ) 12 Diagnostic value of combined detection with fractional exhaled nitric oxide level and induced sputum eosinophils in patients with asthma-chronic obstructive pulmonary disease overlap syndrome,asthma,chronic obstructive pulmonary disease WANG Su-xing Objective To explore the diagnostic value of combined detection with fractional exhaled nitric oxide (FeNO)level and induced sputum eosinophils (EOS) in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS),asthma,chronic obstructive pulmonary disease (COPD).Methods A total of 120 patients who were diagnosed and treated in respiratory medicine department of our hospital from January 2017 to January 2019 were enrolled as study objects.According to disease types,they were divided into ACOS group,asthma group and COPD group,40 cases in each group.Another 40 healthy people with the same gender and age who underwent physical examination at the same period were enrolled as control group.The changes in FeNO and induced sputum EOS were observed.Receiver operating characteristic (ROC) curve and diagnostic efficiency of FeNO,induced sputum EOS and their combination for detecting ACOS,asthma and COPD were compared.Results The level of FeNO and induced sputum EOS in ACOS group,asthma group and COPD group were higher than those in control group,and there were statistically significant differences between any two of the three groups (P＜0.05).ROC curve analysis showed that accuracy and specificity of FeNO combined with induced sputum EOS for detecting ACOS,asthma,and COPD were higher than those of their single detection,with statistically significant differences (P＜0.05).Conclusion The combined detection of FeNO and induced sputum EOS can increase diagnostic value in ACOS,asthma and COPD. 2020 Vol. 27 (5): 12-15 [Abstract] ( 73 ) HTML (37 KB)  PDF  (0 KB)  ( 14 ) 16 Research progress of Levonorgestrel intrauterine contraceptive system for gynecological diseases YI Ting-yan； LI Jian-xia；LUO Xue-mei Levonorgestrel intrauterine contraceptive system (LNG-IUS),as a new type of intrauterine hormone contraceptive device imported from abroad,is a safe,effective and acceptable contraceptive method.LNG-IUS is released into uterine cavity at a dose of 20 μg Levonorgestrel (LNG) per day,which has comprehensive effects of thickening cervical mucus,preventing sperm from moving in uterine cavity and fallopian tube,inhibiting endometrial proliferation,etc.Like oral contraceptives,it has therapeutic effects other than contraception.LNG-IUS can effectively treat various gynecological diseases,including menorrhagia,hysteromyoma,endometriosis and adenomyosis with dysmenorrhea and endometrial hyperplasia.It can be used as an alternative to hysterectomy for women with bleeding problems,and can protect the endometrium in estrogen replacement therapy,and even has a certain alleviation effect on the early stage of endometrial cancer.This article aims to discuss the research progress of LNG-IUS in the treatment of gynecological diseases. 2020 Vol. 27 (5): 16-18转33 [Abstract] ( 85 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 19 Research progress of lymphoma risk in inflammatory bowel disease treated with Azathioprine SHEN Yan-li ；ZHANG An-xing； LUO Juan ；MIAO Ying-lei▲ In recent years,there have been more and more reports of lymphoma in patients with inflammatory bowel disease (IBD).Most studies have recognized that patients with IBD have a low risk of developing lymphoma,but the risk of lymphoma significantly increases in those patients treated with Azathioprine (AZA).At present,the adverse reactions of AZAwhich is the most commonly used as immunosuppressant in IBD patients have attracted more and more attention from clinicians.This article reviews not only the risk and possible mechanisms of lymphoma induced by AZAin patients with IBD,but also the clinical benefits and precautions of IBD patients treated with AZA,so as to help clinicians improve the understanding of the disease. 2020 Vol. 27 (5): 19-22 [Abstract] ( 111 ) HTML (39 KB)  PDF  (0 KB)  ( 13 ) 23 Research progress on the drying and processing technology of Radix Codonopsis GENG Xue； ZHENG Gui-sen； QIANG Zheng-ze； WEI Xin-gang； LI Han-bo；WANG Miao； CHEN Ye-jia Radix Codonopsis is a commonly used tonics in traditional Chinese medicine formulas.There are several major categories such as "Ludang" "Xidang" and "Tiaodang".Drying and processing technology are very important parts of ensuring the medicinal properties and efficacy of Radix Codonopsis.This article has compiled the development of the drying and processing technology of Radix Codonopsis by certificating the ancient and modern herbal literatures.The drying history of Radix Codonopsis has been recorded since the Qing dynasty,and it has developed into modern time,mainly including airing,sun-drying and stoving.The latest edition of Chinese Pharmacopoeia (2015 edition) stipulates that the drying method of Radix Codonopsis is "sun-drying".The traditional drying and processing technology cannot meet the needs of large-scale and standardized production processing.It is urgent to study and develop new drying and processing technology that can guarantee the quality of Radix Codonopsis. 2020 Vol. 27 (5): 23-26 [Abstract] ( 88 ) HTML (42 KB)  PDF  (0 KB)  ( 5 ) 27 Research progress of the relationship between chorioamnionitis and neonatal respiratory diseases MENG Fan-lu； LI Yu-fen； WANG Wei-can； JIAO Hong-mei Chorioamnionitis is an inflammatory reaction of maternal placenta.It has a high incidence in maternal women and can cause serious complications.It is also closely related to the prognosis of neonatal diseases,which seriously endangers the safety of pregnant women and newborns.At present,the incidence of chorioamnionitis is increasing year by year,which may cause adverse effects such as premature rupture of membranes,premature delivery,pregnancy and neonatal infection.The intrauterine inflammatory response of the mother can directly lead to an increase in the prevalence of neonates,especially in respiratory diseases,so early identification and rapid diagnosis can help reduce the recent complications of the mother and child and improve the long-term prognosis of the newborn.This article reviews the relationship between chorioamnionitis and neonatal respiratory diseases. 2020 Vol. 27 (5): 27-29 [Abstract] ( 93 ) HTML (34 KB)  PDF  (0 KB)  ( 17 ) 30 Clinical significance of dynamic monitoring of procalcitonin on antibiotic use in patients with ICU sepsis CHEN Tian-ming； CHEN Yuan-ping； YANG Li-ping； ZHU Li-li Objective To explore the dynamic monitoring of procalcitonin (PCT) in guiding the use of antibiotics in patients with sepsis.Methods A total of 90 patients with sepsis admitted to our hospital from August 2016 to August 2018 were selected as subjects.According to whether the dynamic PCT monitoring was performed or not,they were divided into the conventional group (n=42) and the PCT group (n=48).All were routinely monitored and treated with a sepsis treatment regimen.The standard of the guideline was used to determine the antibiotic treatment plan in the control group.The PCT group was monitored by PCT on the 1st,3rd,5th,7th,and 9th days after admission,and the antibiotic application program was considered comprehensively.The time and cost in the intensive care unit (ICU),antibacterial use time,and mortality were compared between the two groups.According to the patient outcome,the PCT group was further divided into the death group (n=8) and the survival group (n=40).The PCT value,sequential organ failure assessment (SOFA) score,acute physiology and chronic health (APACHE Ⅱ) score between the death group and the survival group were compared.Results There was no significant difference in death rate between the conventional group and the PCT group (P＞0.05).The ICU stay timeand antibiotic use time in the PCT group were shorter than those in the conventional group,the ICU hospitalization cost of the PCT group was lower than that of the conventional group,the differences were statistically significant (P＜0.05).The SOFA score,APACHE Ⅱscore and PCT levels on the 1st,3rd,5th,7th and 9th days after admission of PCT survival group were lower than those of the death group,the differences were statistically significant (P＜0.05).Conclusion PCT dynamic monitoring can not only judge whether patients have bacterial infection,the degree of infection and prognosis of patients,but also guide clinical rational drug use,reduce ICU hospital stay as well as cost,and has good clinical value,which is worthy of promotion. 2020 Vol. 27 (5): 30-33 [Abstract] ( 77 ) HTML (36 KB)  PDF  (0 KB)  ( 12 ) 34 Application effect of low leukocyte blood transfusion technology in blood transfusion ZHANG Ying-qi Objective To investigate the application effect of low leukocyte blood transfusion technology in blood transfusion.Methods A total of 180 cases of transfusion patients admitted to a tertiary hospital in Fuxin city from November 2015 to September 2018 were selected as subjects.They were divided into experimental group (odd number,90 cases and reference group(even number,90 cases)according to the order of patients admitted to hospital.The patients in the control group were transfused by conventional blood transfusion technique,while the patients in the experimental group were transfused by low leucocyte transfusion technique.The incidence of adverse reactions and cross matching rate of blood transfusion in the two groups were compared.Results The total incidence of adverse reactions in the experimental group (1.11%) was lower than that in the control group (15.56%),and the cross-match rate of patients in the experimental group (95.56%) was higher than that in the control group (82.22%),and the differences were statistically significant (P＜0.05).Conclusion The low leukocyte blood transfusion technology has significant effect on reducing the incidence of adverse reactions and increasing the rate of cross matching,and has high clinical application value. 2020 Vol. 27 (5): 34-36 [Abstract] ( 90 ) HTML (30 KB)  PDF  (0 KB)  ( 11 ) 37 Effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of idiopathic interstitial pneumonia JI Shang-ming Objective To investigate the clinical effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of patients with idiopathic interstitial pneumonia.Methods A total of 62 patients with idiopathic interstitial pneumonia who were treated in our hospital from December 2012 to December 2017 were selected as the research subjects.They were divided into the control group and the observation group according to the random number table method,with 31 cases in each group.The control group was treated with Prednisone and Azathioprine,patients in the observation group were treated with Acetylcysteine on the basis of the control group.The clinical efficacy and pulmonary function indicators (vital capacity [VC],forced expiratory volume in one second occupying forced vital capacity[FEV1/FVC]and dispersion coefficient [DICO]) before and after treatment were compared in the two groups.The incidence of adverse reactions during the treatment of the two groups was recorded.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There were no significant differences in the pulmonary function indicators between the two groups before treatment (P＞0.05).The VC,FEV1/FVC and DICO after treatment in the two groups were higher than those before treatment,and the VC,FEV1/FVC and DICO in the observation group were higher than those in the control group,with statistically significant differences (P＜0.05).No significant adverse reactions occurred in the two groups of patients.Conclusion The clinical effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of patients with idiopathic interstitial pneumonia is better than that of Prednisone and Azathioprine,and it can improve the pulmonary function indicators of patients,with reliable safety. 2020 Vol. 27 (5): 37-39 [Abstract] ( 89 ) HTML (32 KB)  PDF  (0 KB)  ( 6 ) 40 Application value of polysomnography in the diagnosis of obstructive sleep apnea syndrome LIN Dong-mei ；YANG Long； TAO Zhi-ping； GAO De-qiang ；SUN Xu Objective To investigate and evaluate the application value of polysomnography in the diagnosis of obstructive sleep apnea syndrome (OSAS).Methods From December 2016 to December 2018,61 patients with OSAS diagnosed in our hospital were selected as the subjects.All patients were diagnosed by polysomnography and portable sleep monitor.The average blood oxygen saturation,minimum nocturnal oxygen saturation and oxygen reduction index of the patients examined by different monitoring methods were recorded and compared.The detection rate and severity of OSAS diagnosed by two sleep monitoring methods were counted.Results The mean blood oxygen saturation,the lowest blood oxygen saturation and oxygen desaturation inder at night were all lower than those of the portable sleep monitoring method,there were significant differences between the two groups (P ＜0.05).The overall detection rate of polysomnography in patients with OSAS was 100.00%,which was higher than that in portable sleep monitoring of 80.33%,there was significant difference between the two groups (P＜0.05).The detection rate of polysomnography in patients with moderate and mild OSAS both were 100.00%,which were higher than the 72.73% and 77.78% of the portable sleep monitoring,and there were significant differences between the two groups (P ＜0.05).Conclusion Polysomnography can well monitor the indexes of patients with OSAS and improve the detection rate of OSAS.It is a scientific and effective diagnostic method. 2020 Vol. 27 (5): 40-42 [Abstract] ( 98 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 43 Clinical effect of pulmonary protective ventilation in the treatment of severe chest trauma complicated with acute respiratory distress syndrome and its effect on ventilation function LIANG Lei ；JIANG Wei Objective To investigate the clinical effect of pulmonary protective ventilation in patients with severe chest trauma complicated by acute respiratory distress syndrome (ARDS).Methods In this study,66 patients with severe chest trauma complicated with ARDS admitted to ICU from April 2016 to April 2019 were selected as subjects and divided into control group (33 cases) and observation group (33 cases) according to the random number table method.The control group received routine ventilation and conventional treatment,the observation group was given lung protective ventilation treatment.The clinical efficacy,blood gas analysis indicators before and after ventilation,assisted ventilation time and mortality of the two groups were compared.Results The total clinical efficiency of the patients in the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The values of oxygen partial pressure (PaO2),carbon dioxide partial pressure (PaCO2),and oxygen index (PaO2/FiO2) were compared between the two groups of patients with no statistical significance (P＞0.05).After 8 and 24hof ventilation,PaO2 and PaO2/FiO2 of two groups were higher than those before ventilation,and PaCO2 was lower than that before ventilation,the differences were statistically significant (P＜0.05).The PaO2 and PaO2/FiO2 after 8 and 24hof ventilation in the observation group were higher than those in the control group,and PaCO2 was lower than that in the control group,and the differences were statistically significant (P＜0.05).The auxiliary ventilation time in the observation group was shorter than that of the control group,and the difference was statistically significant (P＜0.05).The mortality of patients in the observation group was lower than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion The effect of lung protective ventilation treating patients with severe chest trauma complicated with ARDS disease is remarkable.It can improve the blood gas analysis index and reduce the auxiliary ventilation time and mortality after ventilation.It has important clinical significance. 2020 Vol. 27 (5): 43-45转49 [Abstract] ( 73 ) HTML (40 KB)  PDF  (0 KB)  ( 16 ) 46 Clinical effect of Octreotide combined with gastroscopic intervention in the treatment of peptic ulcer with upper gastrointestinal hemorrhage WU Ke Objective To explore the clinical effect of Octreotide combined with gastroscopy in the treatment of peptic ulcer with upper gastrointestinal hemorrhage.Methods Eighty-two patients with peptic ulcer and upper gastrointestinal hemorrhage admitted to the hospital from June 2017 to June 2019 were selected as subjects and divided into observation group and control group according to the random number table method,with 41 cases in each group.Control group was given gastroscopic intervention,and observation group was combined with Octreotide on this basis,and both groups were given basic treatment.The clinical efficacy,stopping time of hematemesis,hospital stay,rebleeding rate within 48h and occurrence of adverse reactions were observed and compared between the two groups.Results The total effective rate of clinical treatment in observation group was higher than that in control group,the difference was statistically significant (P＜0.05).The stopping time of hematemesis and hospital stay in observation group were shorter than those in control group,the differences were statistically significant (P＜0.05).The 48 h rebleeding rate in observation group was lower than that in control group,the difference was statistically significant (P＜0.05).There was no statistically significant difference in the total incidence rate of adverse reactions between the two groups (P＞0.05).Conclusion Octreotide combined with gastroscopic intervention has good clinical effect,early stopping of hematemesis,short hospital stay and low rebleeding rate within 48 h in the treatment of peptic ulcer with upper gastrointestinal hemorrhage,thus it is worthy of popularization and application. 2020 Vol. 27 (5): 46-49 [Abstract] ( 77 ) HTML (35 KB)  PDF  (0 KB)  ( 15 ) 50 Analysis of influential factors of prognosis in patients with traumatic brain injury SUN Guo-zhang；JIANG Feng-ling； LI Ying； MA Bo-wen； LIU Ting； TAO Yu Objective To analyze the influential factors of prognosis in patients with traumatic brain injury and provide scientific basis for clinical decision-making.Methods The clinical data of 67 patients with traumatic brain injury admitted to Heilongjiang Provincial Hospital from April to July 2018 were retrospectively analyzed,they were divided into good prognosis groups (37 cases) and poor prognosis group (30 cases) according to the prognosis of 3 months after discharge and different Glasgow prognosis grade (GOS).Univariate and multivariate of clinical influencing factors of prognosis in patients with traumatic brain injury were analysed.The prediction ability of Logistic regression model was evaluated by receiver operating characteristic (ROC) curve,area under the curve (AUC),sensitivity and specificity.Results Univariate analysis showed that the age,hematoma volume,blood glucose,white blood cell and neutrophil counts of the poor prognosis group were higher than those of the good prognosis group,and the Glasgow coma score (GCS) and blood calcium level at the first diagnosis were lower than those of the good prognosis group,the differences were statistically significant (P＜0.05).Multivariate Logistic regression analysis showed that the first diagnosis of GCS (β=-0.367,OR=0.693,95%CI=0.554-0.867) score was a protective factor for poor prognosis in patients with traumatic brain injury.White blood cell count (β=0.249,OR=1.283,95%CI=1.053-1.562) was an independent risk factor for poor prognosis in patients with traumatic brain injury (P＜0.05).Regression model AUC was 0.906,sensitivity and specificity were 93.3%and 83.8%,respectively.Conclusion The first diagnosis of GCS score and white blood cell count are independent related factors that affect the prognosis of patients with traumatic brain injury.Clinically detectable levels of the two have important significance for the prognosis of patients with brain injury. 2020 Vol. 27 (5): 50-52转56 [Abstract] ( 96 ) HTML (34 KB)  PDF  (0 KB)  ( 11 ) 53 Clinical effect of minimally invasive catheterization combined with Urokinase infusion in the treatment of cerebellar hemorrhage WU Shi-qiang； LUO An-lin ；FANG Ting； GUAN Hui-dong； LI Wen-tian Objective To observe the clinical effect of minimally invasive catheterization combined with Urokinase infusion in the treatment of cerebellar hemorrhage.Methods Fifty patients with cerebellar hemorrhage admitted to our hospital from January 2016 to December 2018 were enrolled in the study,and they were divided into the reference group (n=25) and the experimental group (n=25) according to the hidden number random method.The reference group was treated with conservative medical methods,and the experimental group was treated with minimally invasive catheterization combined with Urokinase infusion.The Glasgow coma scale (GCS) and national institute of health stroke scale (NIHSS) were used to evaluate the short-term efficacy before treatment and 2 weeks after treatment.The duration of coma,hospital stay and incidence of complications were compared between the two groups.All patients were followed up for 6 months,and activity of daily living (ADL) was used to evaluate the prognosis of patients.Results The NIHSS scores at 2 weeks after treatment in the two groups were lower than those at admission,and the GCS scores were higher than those at admission,with statistically significant differences (P＜0.05).The NIHSS score at 2 weeks after treatment in the experimental group was lower than that in the reference group,and the GCS score was higher than that in the reference group,with statistically significant differences (P＜0.05).There was no significant difference in the duration of coma between the two groups (P＞0.05).The hospital stay in the experimental group was shorter than that in the reference group,and the total incidence rate of complications was lower than that in the reference group,with statistically significant differences (P＜0.05).After 6 months of follow-up,the good prognosis rate of the experimental group was 64.00%,which was higher than that of the reference group accounting for 52.00%,and the difference was statistically significant (P＜0.05).Conclusion Minimally invasive catheterization combined with Urokinase infusion for cerebellar hemorrhage is an easy,rapid,safe and effective treatment. 2020 Vol. 27 (5): 53-56 [Abstract] ( 71 ) HTML (34 KB)  PDF  (0 KB)  ( 13 ) 57 Clinical effect of laparoscopic surgery in the treatment of patients with pregnancy and acute appendicitis HE Shao-zhen； XU Xin；CHEN Xiao-mei Objective To investigate the clinical effect of laparoscopic surgery in the treatment of patients with pregnancy and acute appendicitis.Methods Sixty pregnant patients with acute appendicitis treated in Yongfeng County Traditional Chinese Medicine Hospital of Jiangxi Province from January 2018 to July 2019 were selected as the research subjects and divided into group A (30 cases) and group B (30 cases) according to the random number table method.Group A was treated with open surgery,and group B was treated with laparoscopy.The surgical time,postoperative anal exhaust time,time to get out of bed,length of hospital stay,total effective rate of treatment and total incidence of complications were compared between the two groups.Results The operation time,postoperative anal exhaust time,time to get out of bed,and hospital stay in group B were shorter than those in group A,the differences were statistically significant (P＜0.05).The total effective rate of group B was higher than that of group A,the difference was statistically significant (P＜0.05).The total incidence of postoperative complications in group B was lower than that in group A,the difference was statistically significant (P＜0.05).Conclusion Laparoscopic surgery for patients with acute appendicitis during pregnancy can effectively save the patient′s surgical time,shorten the patient′s postoperative anal exhaust time,get out of bed activity time and hospital stay,improve the treatment effect of the patient,and reduce postoperative complications.It is worthy of clinical promotion and application. 2020 Vol. 27 (5): 57-59 [Abstract] ( 79 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 60 Clinical effect comparison of endoscopic mucosal resection and endoscopic snare high frequency electrotomy in the treatment of colorectal polyps WANG Xue-qi； LIN Xing-di； NING Ying-qin Objective To compare the clinical effect of endoscopic mucosal resection with endoscopic snare high frequency electrotomy in the treatment of colorectal polyps.Methods Eighty patients with colorectal polyps admitted to our hospital from March 2018 to May 2019 were selected as the research objects,they were divided into experimental group and control group according to the random number table method,with 40 cases in each group.The experimental group underwent endoscopic mucosal resection,the control group underwent endoscopic snare high frequency electrotomy.The operation time,postoperative hospital stay,polypectomy and complications were compared between the two groups.Results The operation time of the experimental group was (9.28±1.27) min,which was longer than (7.62±1.32)min of the control group,the postoperative hospital stay in the experimental group was (3.42±1.98) d,which was shorter than (4.68±1.80) d of the control group,the differences were statistically significant (P＜0.05).Polypectomy was better in the experimental group than that of the control group,the difference was statistically significant (P＜0.05).The total incidence of complications in the experimental group was 5.00%,which was lower than 22.50% in the control group,the difference was statistically significant (P＜0.05).Conclusion Compared with endoscopic snare high frequency electrotomy,endoscopic mucosal resection for patients with colorectal polyps can shorten the patient′s postoperative hospital stay,improve the patients′ polypectomy,and reduce the incidence of complications,which is worthy of clinical application. 2020 Vol. 27 (5): 60-62 [Abstract] ( 81 ) HTML (32 KB)  PDF  (0 KB)  ( 14 ) 63 Clinical effect comparison between the mammatone minimally invasive rotary resection and conventional mastectomy in the treatment of benign breast masses LAI Qing； KE Hua； LIU Bao； CHEN Sheng-xuan ；LI Xiao-hong Objective To compare the clinical effect between mammatone minimally invasive rotary resection and conventional mastectomy in the treatment of benign breast masses.Methods A total of 92 patients with benign breast masses admitted to our hospital from December 2017 to February 2019 were selected as the research subjects,and they were randomly divided into the comparison group (n=46) and the experimental group (n=46) according to the time of admission.Patients in the experimental group were treated with mammatone minimally invasive rotary resection,and patients in the comparison group were treated with conventional mastectomy.The operation time,postoperative healing time,intraoperative blood loss,scar length,total incidence rate of complication,total effective rate of treatment,and scores of life quality before and after treatment in the two groups were observed and compared.Results The operation time and postoperative healing time of patients in the experimental group were shorter than those in the comparison group,intraoperative blood loss was less than that in the comparison group,and scar length was shorter than that in the comparison group,with statistically significant differences (P＜0.05).The quality of life score of the experimental group after treatment was higher than that of the comparison group,and the difference was statistically significant (P＜0.05).The total incidence rate of complications in the experimental group (2.17%) was lower than that in the comparison group (15.22%),with statistically significant difference (P ＜0.05).The total effective rate of treatment in the experimental group (97.83%) was higher than that in the comparison group (84.78%),with statistically significant difference (P＜0.05).Conclusion Mammatone minimally invasive rotary resection in the treatment of patients with benign breast masses can improve the quality of life,reduce the incidence of complications,improve the total effective rate of treatment,shorten the operation time,accelerate the postoperative healing,reduce intraoperative blood loss and shorten the scar length,which is worth promoting. 2020 Vol. 27 (5): 63-66 [Abstract] ( 76 ) HTML (35 KB)  PDF  (0 KB)  ( 9 ) 67 Application effect of procedure for prolapse and hemorrhoids on patients with severe haemorrhoids HU Xiao-sheng；SHI Pin-ting Objective To explore application effect of procedure for prolapse and hemorrhoids (PPH) on patients with severe haemorrhoids.Methods A total of 60 patients with severe haemorrhoids who were admitted to the Department of Gastrointestinal Surgery in Jingdezhen No.1 People′s Hospital from March 2017 to March 2019 were enrolled as subjects.According to random number table method,they were divided into control group and observation group,30 cases in each group.The control group was given traditional hemorrhoidectomy,while observation group was treated with PPH.The operation time,intraoperative blood loss and hospitalization time were compared between the two groups.The maximal tolerable rectal volume (MTV),maximum systolic pressure (MSP) and high pressure zone (HPZ) before and after treatment were compared between the two groups.The clinical curative effect and total incidence of postoperative complications in both groups were statistically analyzed.Results The total therapeutic response rate of treatment in observation group was 86.67%,which was higher than that in control group of 63.33%,the difference was statistically significant (P＜0.05).The operation time and hospitalization time in observation group were shorter than those in the control group,and intraoperative blood loss was less than that in control group,the differences were statistically significant(P＜0.05).After treatment,levels of MTV,MSP and HPZ in observation group were higher than those in control group,the differences were statistically significant (P＜0.05).The overall incidence of complications in the observation group was 10.00%,compared with 23.33% in the control group,showing no significant difference (P＞0.05).Conclusion The curative effect of PPH is significant on severe haemorrhoids,which can significantly shorten operation time and hospitalization time,with less bleeding volume,and fewer influences on anorectal dynamics. 2020 Vol. 27 (5): 67-70 [Abstract] ( 73 ) HTML (36 KB)  PDF  (0 KB)  ( 11 ) 71 Application of self-made ankle pump trainer combined with air wave pressure therapy in the prevention of deep venous thrombosis after lower extremity fracture WANG Chuan-xiang； HUANG Jing-quan； Shi Gen-nv Objective To analyze the application value of self-made ankle pump trainer combined with air wave pres-sure therapy in the prevention of deep venous thrombosis after lower extremity fracture.Methods A total of 100 patients who underwent lower extremity fracture surgery in our hospital from October 2017 to October 2018 were selected as the subjects.They were divided into group A and group B according to the random number table method,with 50 cases in each group.Group A received conventional training methods after operation,and group B received self-made ankle pump trainer combined with air wave pressure therapy instrument after operation.The clinical effects of the two groups were compared.Results The peripheral diameter of thigh and calf in group B was smaller than that in group A after intervention,and the difference was statistically significant (P＜0.05).The incidence of lower extremity deep venous thrombosis in group B was lower than that in group A,and the difference was statistically significant (P＜0.05).The score of lower limb swelling in group B was lower than that in group A,and the AOFAS ankle-hindfoot score was higher than that in group A,with statistically significant differences (P＜0.05).Conclusion The application of self-made ankle pump trainer combined with air wave pressure therapy in patients underwentlower extremity fracture surgery can reduce the occurrence of deep vein thrombosis,improve the function of ankle joint and reduce the inner diameter of lower extremity,which is worthy of clinical application. 2020 Vol. 27 (5): 71-73转81 [Abstract] ( 99 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 74 Clinical effect of individualized 3D printing model assisted posterior fixation in the treatment of atlantoaxial instability LIN Jun-hua ；ZHAO Shan-ming； ZHANG Jian-rong； CHEN Jin-ming； LI Xiao-xiong Objective To analyze the clinical effect of individualized 3D printing model assisted posterior fixation in the treatment of atlantoaxial instability.Methods From January 2017 to December 2018,20 patients with atlantoaxial instability treated in our hospital were selected as the subjects,and divided into control group and study group by random number table method,with 10 cases in each group.The patients in the control group were treated with internal fixation with bare hands according to experience,and patients in the study group were treated with 3D printing technology to establish an individualized 3D printing model of cervical spine.Analog nailing and internal fixation were used before operation.Fixation was processed to obtain individualized data of nail placement,which provided assistance for real operation.One-stage posterior decompression and internal fixation were performed on patients.The operation time,bleeding volume,and pain score,Japanese Orthopaedic Association (JOA) score,atlas odontoid space,medulla oblongata cervical spinal cord angle before and after operation were compared between the two groups.Results The operation time of the study group was shorter than that of the control group,and the difference was statistically significant(P＜0.05).The amount of bleeding in the study group was less than that in the control group,and the difference was statistically significant (P＜0.05).After operation,the pain score in the study group was lower than that before operation,JOA score was higher than that before operation,atlas odontoid space was smaller than that before operation,and medulla oblongata cervical spinal angle was lager than that before operation,the differences were statistically significant (P＜0.05).There was no significant difference in pain score and JOA score of the control group before and after operation (P＞0.05).In the control group,the atlanto odontoid space after operation was smaller than that before operation,and the medulla oblongata angle was lager than that before operation,the differences were statistically significant (P＜0.05).There were no significant differences in preoperative pain score,JOA score,atlanto odontoid space and medullary angle between the two groups (P＞0.05).After operation,the pain score in the study group was lower than that in the control group,the JOA score was higher than that in the control group,the atlas odontoid space was smaller than that in the control group,and medulla oblongata cervical spinal angle was lager than that in the control group,the differences were statistically significant (P＜0.05).Conclusion For patients suffering from atlantoaxial instability,applying individualized 3D print model to assist the posterior fixation can improve the success rate of screw setting,protect nerve root and vertebral artery with favorable safety.The treatment effect of using individualized 3D print model to assist the posterior fixation is significant for patients suffering from congenital vertebral malformation and high-riding vertebral artery. 2020 Vol. 27 (5): 74-77 [Abstract] ( 75 ) HTML (36 KB)  PDF  (0 KB)  ( 10 ) 78 Clinical effect of free inguinal skin flap in repairing foot and ankle soft tissue defects YANG Zheng-lu； CHEN Feng； HU Yuan-hui； AI Ming-yang Objective To explore the clinical effect of free inguinal skin flap in repairing foot and ankle soft tissue defects.Methods Forty patients with soft tissue defects of the ankle and foot treated in our hospital from January 2013 to January 2018 were selected as the research objects,they were divided into experimental group (20 cases) and control group (20 cases) according to the random number table method.The experimental group used the free inguinal skin flap repair method,and the control group used the sural neurotrophic pedicled skin flap repair method.The total incidence of complications and the rate of plastic surgery 3-6 months after operation were compared between the two groups,and the typical cases were analyzed.Results The total incidence of postoperative complications in the experimental group was lower than that in the control group,the difference was statistically significant (P＜0.05).The plastic surgery rate in the experimental group 3 to 6 months after surgery was lower than that in the control group,the difference was statistically significant (P＜0.05).Conclusion Compared with pedicled flaps,free inguinal skin flap can reduce the incidence of postoperative complications when repairing skin defects in the feet and ankles.The appearance of the flaps is satisfactory,and secondary plastic surgery is not required.It has a good development prospect. 2020 Vol. 27 (5): 78-81 [Abstract] ( 86 ) HTML (32 KB)  PDF  (0 KB)  ( 15 ) 82 Application effect of Sodium Aescinate for injection in patients undergoing hip joint replacement surgery CAI Zi-jun Objective To probe into the application effect of Sodium Aescinate for injection in patients undergoing hip joint replacement surgery.Methods The clinical data of 105 cases of patients undergoing artificial hip joint replacement surgery in the orthopaedics department of our hospital from June 2017 to January 2018 were retrospectively analyzed,and the patients were divided into the group A (53 cases) and group B (52 cases) according to different treatment methods.The group A was treated with Sodium Aescinate,while the group B was treated with Dexamethasone.The wound healing time,pain relief time,incidence of postoperative complications and visual analogue scale (VAS) score before and after treatment of the two groups of patients were compared.Results The wound healing time and pain relief time in the group A were shorter than those in the group B,and the differences were statistically significant (P＜0.05).There was no significant difference in VAS score between the two groups before treatment (P＞0.05).After the treatment,the VAS score in the group A was lower than that in the group B,and the difference was statistically significant (P＜0.05).The VAS scores of the two groups after treatment were lower than those before treatment,and the differences were statistically significant (P＜0.05).The total incidence rate of postoperative complications in group A was 7.55%,which was lower than that in group B accounting for 17.31%,and the difference was statistically significant (P＜0.05).Conclusion The scientific,reasonable and effective injection of Sodium Aescinate combined with the specific condition of patients in the clinical treatment of hip joint replacement surgery can effectively prevent the incidence of postoperative complications,and it has good clinical application and promotion value. 2020 Vol. 27 (5): 82-84 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 85 Clinical effect of arthroscopy assisted treatment of ankle fractures ZHANG Hong-zhi； TIAN Li Objective To explore the clinical effect of arthroscopy assisted treatment of ankle fractures.Methods A total of 64 patients with ankle fractures treated in Shenzhen Bao′an People′s Hospital from April 2017 to December 2018 were selected as the research subjects,they were divided into control group (32 cases) and observation group (32 cases)according to different treatment methods.The control group received conventional surgery and the observation group received arthroscopyassisted treatment.The surgical indexes,treatment effect and postoperative adverse reactions were compared between the two groups.Results There were no significant differences in surgical time and fracture healing time between the two groups (P＞0.05).The intraoperative blood loss in the observation group was less than that in the control group,and the length of the surgical mouth was shorter than that in the control group,the incidence rates of traumatic arthritis and articular surface reduction ＜2 mm were lower than those in the control group,the differences were statistically significant (P＜0.05).The total effective rate of treatment in the observation group was 90.63%,which was higher than 50.00% in the control group,the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant (P ＜0.05).Conclusion Arthroscopyassisted treatment of ankle fractures can improve various indicators of surgery,improve the treatment effect of patients,and reduce the incidence of adverse reactions in patients,which is worthy of clinical application. 2020 Vol. 27 (5): 85-87 [Abstract] ( 63 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 88 Application of Nadroparin Calcium and Fondaparinux Sodium in preventing deep vein thrombosis of patients with spinal fractures TONG Jian-ping Objective To investigate the application of Nadroparin Calcium and Fondaparinux Sodium in preventing deep vein thrombosis (DVT) of patients with spinal fractures.Methods Sixty patients with spinal fractures who underwent surgical treatment in our hospital from January to June 2019 were selected as the research subjects,they were divided into NC group and FS group according to the random number table method,with 30 cases in each group.The NC group was given Nadroparin Calcium early,the FS group was given Fondaparinux Sodium early,and another 35 healthy volunteers who were admitted for physical examination during the same period were selected as the control group.The incidence of DVT was compared between NC group and FS group.The three groups were compared in terms of coagulation indexes (activated partial thromboplastin time[APTT],platelet count[PLT],fibrinogen[FIB],D-dimer[D-D],antithrombin Ⅲ[AT-Ⅲ]),hemorheology indexes (low-cut viscosity of whole blood [LWBV],high-cut viscosity of whole blood [HWBV],hematocrit[HCT],[erythrocyte sedimentation rate[ESR],platelet aggregation rate[PAR]),blood flow velocity of lower extremity vein (bilateral femoral vein and popliteal vein of lower extremity).The incidence of adverse drug reactions and hospitalization time were compared between NC group and FS group.Results There was no significant difference in DVT incidence between NC group and FS group (P＞0.05).The APTT of the NC group and the FS group was shorter than that of the control group,the levels of Fib and D-D were higher than those of the control group,the AT-Ⅲlevels of the NC group were significantly lower than those of the FS group and the control group,the differences were statistically significant (P＜0.05).There was no significant difference in PLT comparison among the three groups (P＞0.05).There were no significant differences in blood flow velocity of LWBV,HWBV,HCT,ESR and PAR among the three groups (P＞0.05).There were no significant differences in the left femoral vein,right femoral vein,left iliac vein,and right iliac vein among the three groups (P＞0.05).There were no significant differences in the incidence of incision bleeding,bleeding at other sites,anemia/thrombocytopenia,nausea/vomiting,and length of hospital stay in the NC and FS groups (P＞0.05).Conclusion The preventive application of Nadroparin Calcium or Fondaparinux Sodium in patients with spinal fracture after operation can improve the coagulation index,not affect the hemorheology index of patients,not increase the incidence of DVT and adverse drug reactions of patients.The clinical use of Nadroparin Calcium or Fondaparinux Sodium should be based on the situation of patients. 2020 Vol. 27 (5): 88-91 [Abstract] ( 84 ) HTML (37 KB)  PDF  (0 KB)  ( 15 ) 92 Effect of modified Stoppa incision approach treating pelvic acetabular fracture and its effect on hip joint function HUANG Ji-jia ；CHEN Ge-hai； LU Xiao-yan ；HUANG Wei-zhen； CHEN Chu-ming Objective To investigate the clinical effect of modified Stoppa incision approach treating pelvic acetabular fractures and its effect on hip joint function.Methods A total of 68 patients with pelvic acetabular fractures from May 2017 to May 2019 in department of orthopaedics of our hospital were selected as the subjects.The patients were divided into experimental group(n=38)and control group(n=30)according to the patients′wishes.Patients in the control group were treated via sacral inguinal approach,and patients in the experimental group were treated with modified Stoppa incision approach.The clinical effects and hip function of the two groups were compared.Results The operation time,length of operative incision and hospital stay in the experimental group were shorter than those in the control group,and the intraoperative blood loss was less than that in the control group,the differences were statistically significant(P＜0.05).The hip function scores of both groups at discharge and 1 month after discharge were higher than those before operation,with statistical significances (P＜0.05).There were no significant differences in the hip function scores between the two groups before,at discharge and 1 month after discharge (P＞0.05).The scores of quality of life scale (SF-36) in the experimental group were higher than those of the control group 1 month after discharge,the differences were statistically significant (P＜0.05).Conclusion The modified Stoppa incision approach and the iliac groin approach are both effective in the treatment of pelvic acetabular fractures.However,the modified Stoppa incision approach has the advantages of shorter operation time,less trauma and less intraoperative bleeding,which is in line with the minimally invasive concept of modern medicine. 2020 Vol. 27 (5): 92-94 [Abstract] ( 74 ) HTML (32 KB)  PDF  (0 KB)  ( 7 ) 95 Application effect of three-stitch method combined with new knotting method in prophylactic ileostomy for mid and low rectal cancer ZHENG Qiu-xia； WANG Zhan-hui； LI Dong-liang； SUN Zong-bin；WANG Hai-quan； SUN Sheng-an Objective To explore the application effect of three-stitch method combined with new knotting method in prophylactic ileostomy for mid and low rectal cancer.Methods The clinical data of 68 patients undergoing prophylactic ileostomy for low and middle rectal cancer in General Surgery Department of Luoyang Central Hospital Affiliated to Zhengzhou University from December 2014 to January 2019 were retrospectively analyzed,and they were divided into observation group (36 cases) and control group (32 cases) according to different knotting methods.Patients in the observation group used the three-stitch method combined with new knotting method,while patients in the control group used the traditional knotting method.The incidence rates of postoperative stoma stenosis and stoma separation,and the time of knotting and suture were compared between the two groups of patients.Results The incidence rates of postoperative stoma stenosis and stoma separation in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).The time of knotting and suture in the observation group was shorter than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion Compared with traditional knotting methods,the three-stitch method combined with new knotting method can significantly reduce the incidence rates of stoma stenosis and stoma separation,and shorten the time of knotting and suture.The effect is remarkable,and this method is simple and worthy of clinical application. 2020 Vol. 27 (5): 95-97转101 [Abstract] ( 73 ) HTML (35 KB)  PDF  (0 KB)  ( 12 ) 98 Clinical effect of Tegio combined with three-dimensional conformal radiotherapy in the treatment of esophageal cancer ZOU Yong-bin； CAO Hui Objective To investigate the clinical effect of Tegio combined with three-dimensional conformal radiotherapy in the treatment of esophageal cancer.Methods A total of 86 patients with esophageal cancer admitted to our hospital from January 2013 to December 2015 were selected as the research objects,and they were divided into observation group (n=43) and control group (n=43) according to the order of consultation.The control group was treated with threedimensional conformal radiotherapy,while the observation group was treated with Tegio combined with three-dimensional conformal radiotherapy.The clinical treatment effect,clinical symptom relief,1 and 3-year survival rates and the incidence of adverse reactions of the two groups of patients were observed.Results The objective remission rate of patients in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).The dysphagia and superior vena cava syndrome remission rates in the observation group were higher than those in the control group,with statistically significant differences (P＜0.05).There was no significant difference in chest and back pain remission rate between the two groups (P＞0.05).The 1 and 3-year survival rates in the observation group were higher than those in the control group,with statistically significant differences (P＜0.05).There was no significant difference in the total incidence rate of adverse reactions between the two groups of patients (P＞0.05).Conclusion Tegio combined with three-dimensional conformal radiotherapy in the treatment of esophageal cancer has significant effect,fewer toxicity and side effects,and has high clinical application value. 2020 Vol. 27 (5): 98-101 [Abstract] ( 71 ) HTML (36 KB)  PDF  (0 KB)  ( 9 ) 102 Effect of lung protective ventilation strategy on inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer ZOU Bin； WANG Jian-bing； TANG Lang； GUO Chang-ying Objective To study the effect of lung protective ventilation strategy on inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer.Methods A total of 75 patients with thoracoscopic radical resection of lung cancer admitted to our hospital from July 2017 to July 2018 were selected as the research objects.All patients were divided into observation group (38 cases) and control group (37 cases) according to the random number table method.The control group was treated with conventional ventilation strategy,and the observation group was treated with lung protective ventilation strategy.The inflammatory response indexes (interleukin-10 [IL-10],interleukin-8[IL-8],tumor necrosis factor-α [TNF-α]) and oxidative stress indexes (malondialdehyde [MDA],superoxide dismutase[SOD]) were compared between the two groups before and after operation.The pulmonary function of the two groups was scored with the standard pulmonary function scale.The incidence of pulmonary complications was recorded within 3 days after operation in both groups.Results The levels of IL-10,IL-8 and TNF-α after operation in the two groups were lower than those before operation,and the differences were statistically significant (P＜0.05).The levels of IL-10,IL-8 and TNF-α in the observation group after operation were lower than those in the control group,and the differences were statistically significant (P＜0.05).The levels of MDA in the two groups after operation were lower than those before operation,SOD and pulmonary function score were higher than those before operation,and the differences were statistically significant (P＜0.05).The MDA of the observation group after operation was lower than that of the control group,SOD and pulmonary function score were higher than those of the control group,and the differences were statistically significant (P＜0.05).The total incidence rate of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The lung protective ventilation strategy can significantly reduce the inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer,and improve the lung function.It has high application value in clinical practice,and it is worth popularizing. 2020 Vol. 27 (5): 102-104 [Abstract] ( 76 ) HTML (33 KB)  PDF  (0 KB)  ( 15 ) 105 Clinical effect of endoscopic submucosal dissection in the treatment of laterally spreading tumor ZENG De-hui ；WANG Fu-qun ；WANG Sheng-bing Objective To investigate the clinical effect of endoscopic submucosal dissection (ESD) in the treatment of lateral large intestine tumors.Methods Ninety patients with laterally spreading tumor treated in Meizhou People′s Hospital of Guangdong Province from January 2015 to May 2018 were selected as the subjects,and divided into control group (45 cases) and observation group (45 cases) by random number table method.The control group was treated with endoscopic mucosal resection (EMR),and the observation group was treated with ESD.Both groups were followed up for 12 months.The surgical indexes,incidence of complications and recurrence rate were compared between the two groups.Results There was no significant difference in intraoperative blood loss between the two groups (P＞0.05).The whole resection rate and complete resection rate in the observation group were higher than those in the control group,the differences were statistically significant (P＜0.05).The incidence of bleeding,intestinal perforation and wound infection was lower than that of the control group,the difference was statistically significant (P＜0.05).There was no significant difference in the recurrence rate at 6 months after operation (P＞0.05).The recurrence rate in the observation group was lower than that in the control group at 12 months after operation,the difference was statistically significant(P＜0.05).Conclusion ESD for the treatment of laterally spreading tumor has less trauma,and the rate of complete resection and complete resection is better than EMR,and the recurrence rate is low,and the incidence of complications is not increased.It is worth promoting. 2020 Vol. 27 (5): 105-107 [Abstract] ( 68 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 108 Present situation of prenatal maternal stress in women with advanced threatened abortion and its effect on fetal protection ZHENG Li-juan； LI Hui ；SU Min-yi ；HUANG Bi-qiong； JIANG Xue-wei ；HU Pin-jia； HU Zu-rong▲ Objective To analyze the present situation of prenatal maternal stress in women with advanced threatened abortion,and to explore its effect on fetal protection.Methods A total of 166 pregnant women with threatened abortion outpatient department of gynecology and obstetrics in our hospital from January to December 2018 were selected as the study group,100 pregnant women with normal pregnancy of 12-28 weeks were selected as the control group.In this study,the scores of general data,Chinese version of perceived stress scale (CPSS),self-rating anxiety scale (SAS),self-rating depression scale (SDS) and life events during pregnancy questionnaire (PLQ) were compared between the two groups.Multivariate Logistic analysis was used to analyze the effect of health risk stress (HRS) on the outcome of threatened abortion.Results There were no significant differences between the two groups in age,gestational age,family income,education level,working status and SDS scores (P＞0.05).The scores of CPSS,HRS and SAS in the study group were higher than those in the control group,the differences were statistically significant (P＜0.05).Logistic regression analysis showed that HRS (β=2.506,OR=12.254,95%CI: 1.762-85.226) was an independent risk factor of late abortion failure (P＜0.05).The study groups′ interpersonal relationship,work pressure,husbands′ work score and PLQ total score were higher than those in the control group,the differences were statistically significant (P＜0.05).Conclusion The prenatal maternal stress of the pregnant women with advanced threatened abortion is significantly higher than that of the pregnant women at the same stage,and the pregnant women with HRS are more likely to have advanced threatened abortion. 2020 Vol. 27 (5): 108-111 [Abstract] ( 69 ) HTML (37 KB)  PDF  (0 KB)  ( 10 ) 112 Effect of different vaginal administration Luteal support scheme on pregnancy outcome in patients with hormone replacement therapy and cycle frozen-thawed embryo transfer ZHAI Guo-min；GAO Yu-lin；HUANG Jian-chu； LAI Wen-yao； ZHONG Wen-bin； LI Tai-kang； ZHOU Xiao-qin Objective To observe the changes of pregnancy outcome in patients with hormone replacement therapy and frozen-thawed embryo transfer (FET) under different vaginal administration Luteal support scheme.Methods The clinical data of a total of 535 cycles of hormone replacement therapy and cycle FET in the reproductive center of Dongguan Maternal and Child Health Hospital from February 2013 to July 2018 was selected for retrospective analysis.The patients were divided into group A and group B according to different vaginal administration schemes.Group A，a total of 263 cycles,patients were treated with Progesterone Vaginal Sustained Release Gel (transvaginal) with Dydrogesterone Tablets (oral).Group B,a total of 272 cycles,patients were treated with Progesterone Soft Capsules (oral) and Dydrogesterone Tablets (oral).The clinical outcomes and adverse reactions of the two groups were compared.Results The rate of embryos implantation in the group A was higher than that in the group B (P＜0.05),and the rate of early abortion in the group A was lower than that in the group B (P＜0.05).The total incidence of adverse reactions in the group A was lower than that in the group B,the differences were statistically significant (P＜0.05).Conclusion Progesterone Vaginal Sustained Release Gel (transvaginal) with Dydrogesterone Tablets (oral) can significantly improve the rates of embryo implantation,decrease the rates of early abortion and adverse reaction. 2020 Vol. 27 (5): 112-114 [Abstract] ( 60 ) HTML (33 KB)  PDF  (0 KB)  ( 16 ) 115 Analysis of related influencing factors of relapse in children with acute lymphoblastic leukemia after CCLG-2008 XIE Shu-pei ；LIANG Chang-da； FAN Xiao-ju Objective To analyze related influencing factors of relapse in children with acute lymphoblastic leukemia(ALL) children after CCLG-2008.Methods A retrospective analysis was performed on 677 newly diagnosed children who were given CCLG-2008 chemotherapy regimen during the period from January 2010 to January 2015.According to results of follow-up,they were divided into recurrence group (151 cases) and non-recurrence group (526 cases).Univariate and multivariate Logistic regression analysis were performed to analyze risk factors influencing recurrence in ALL children after CCLG-2008 treatment regimen.The main factors influencing recurrence of ALL children were analyzed.Results A total of 677 patients were treated.There were 151 cases with recurrence,with recurrence rate of 22.30%.The proportions of age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level in recurrence group were higher than those in non-recurrence group (P＜0.05).Multivariate Logistic regression analysis showed that age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level were independent risk factors influencing recurrence in ALL children(P＜0.05).Conclusion Age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level are independent risk factors influencing recurrence in ALL children. 2020 Vol. 27 (5): 115-117 [Abstract] ( 76 ) HTML (33 KB)  PDF  (0 KB)  ( 8 ) 118 Application effect of balloon bionic midwifery on epidural anesthesia for analgesic delivery in the second stage of labor HAN Chun-ping ；XIAO Wen-ping； LI Juan； XIE Xu-juan Objective To explore the application effect of balloon bionic midwifery on epidural analgesia in the second stage of labor for analgesic delivery.Methods From January 2017 to January 2018,220 pregnant women admitted to our hospital were selected as the research objects.By random number table method,they were divided into control group (routine midwifery) and observation group (balloon bionic midwifery),110 cases in each group.The use of Oxytocin,time of the second stage of labor,outcome of delivery and situation of the newborns were compared between two groups.Results The stage of labor in the observation group was shorter than that of the control group,the Oxytocin utilization rate was lower than that of the control group,and the differences were statistically significant (P＜0.05).The delivery outcome in the observation group was superior to that of the control group,the postpartum hemorrhage rate was lower than that of the control group，with statistical differences (P＜0.05).The asphyxia rate in the observation group was lower than that in the control group,and the difference was significant (P＜0.05).Conclusion The use of balloon bionic midwifery during the second stage of labor for epidural anesthesia and analgesic delivery can greatly reduce the cesarean delivery rate and the asphyxia rate of the newborns,facilitate the delivery process,and increase the maternal delivery success rate. 2020 Vol. 27 (5): 118-120 [Abstract] ( 82 ) HTML (31 KB)  PDF  (0 KB)  ( 10 ) 121 Application effect of hemostatic healing sponge in salpingotomy for embryo LAI Hui-chao； YI Na； XIE Shan； LIU Qiong Objective To analyze the application value of hemostatic healing sponge in salpingotomy for embryo.Methods A total of 58 patients with tubal ectopic pregnancy admitted to Ganzhou People′s Hospital from December 2015 to May 2018 were selected.All patients were treated by laparoscopic salpingotomy,and were divided into observation group (n=28) and control group (n=30) according to the time of admission.The control group adopted Pituitrin to stop bleeding,and the observation group added hemostatic healing sponge on the basis of the control group.The intraoperative blood loss,fallopian tube resection rate and postoperative ectopic pregnancy rate between the two groups were observed.The tubal patency at the affected side,intrauterine pregnancy rate and repeated ectopic pregnancy rate were followed up for one year.Results The amount of bleeding in the observation group was less than that in the control group (P＜0.05).The rate of tubal resection and postoperative ectopic pregnancy in the observation group were lower than those in the control group，the differences were statistically significant (P＜0.05).The patency rate and intrauterine pregnancy rate of the observation group were higher than those of the control group from the one-year follow-up,the differences were statistically significant (P＜0.05).There was no significant difference in the repeat ectopic pregnancy rate between the two groups (P＞0.05).Conclusion The application of hemostatic healing sponge in salpingotomy for embryo can reduce the amount of intraoperative blood loss,thereby reducing the rate of tubal resection,help to improve the prognosis of patients,improve the patency of fallopian tubes and intrauterine pregnancy rate,which is worthy of clinical promotion and application. 2020 Vol. 27 (5): 121-123 [Abstract] ( 67 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 124 Clinical effect of personalized biofeedback combined with pelvic floor muscle exercise in the treatment of postpartum pelvic floor dysfunction PENG Fan-ping； CHEN Hua； ZONG Yi； ZHENG Wei-qin； WU Die Objective To explore the clinical effect of personalized biofeedback combined with pelvic floor muscle exercise in the treatment of postpartum pelvic floor dysfunction.Methods A total of 80 patients with postpartum pelvic floor dysfunction treated in Shenzhen Shajing People′s Hospital and Shenzhen Fuyong People′s Hospital from March 2017 to March 2018 were selected as the research objects,they were divided into study group (42 cases) and control group (38 cases) according to different treatment methods.The study group was treated with individualized biological feedback combined with pelvic floor exercise,the control group was treated with pelvic floor exercise.The pelvic floor muscle strength before and after treatment,clinical treatment effect,and total treatment satisfaction were compared between the two groups.Results After treatment,the mean muscle strength of pelvic floor muscles of type Ⅰand Ⅱin the study group were higher than those in the control group,the differences were statistically significant (P＜0.05).After treatment,the fatigue values of Ⅰand Ⅱmuscle fibers in the study group were lower than those in the control group,the differences were statistically significant (P＜0.05).The total effective rate of treatment in the study group was 92.9%,which was higher than 76.3% in the control group,the difference was statistically significant (P＜0.05).The total treatment satisfaction of the study group was higher than that of the control group,the difference was statistically significant(P＜0.05).Conclusion Personalized biofeedback combined with pelvic floor muscle exercise for patients with postpartum pelvic floor dysfunction can significantly improve the patient′s pelvic floor muscle strength,clinical treatment effect and treatment satisfaction,which is worthy of clinical promotion and application. 2020 Vol. 27 (5): 124-126转130 [Abstract] ( 74 ) HTML (36 KB)  PDF  (0 KB)  ( 7 ) 127 Correlation analysis between changes of coagulation fibrinolysis system and renal injury in children with henoch-schonlein purpura JIANG Xiong ；FENG Zhan-gui ；YUAN Ke-long Objective To analyze the correlation between changes of coagulation fibrinolysis system and renal injury in children with henoch-schonlein purpura (HSP).Methods A total of 76 children with clinical acute pura in our hospital from June 2016 to June 2018 were selected as the study objects,according to the different renal injury indexes,they were divided into HSP group (41 cases) and henoch-schonlein purpura nephritis (HSPN) group (35 cases),20 healthy children in the same period were selected as the control group.The fibrinogen(FIB),D-dimer (D-D),fibrin degradation product (FDP) and renal injury index urine β2-microglobulin (β2-MG) were detected and compared automatically by hemagglutination.Correlation between plasma FIB,D-D,FDP and renal injury index urine β2-MG in HSPN group was analyzed.Results The levels of FIB,D-D,and FDP in the HSP group and HSPN group were higher than those in the control group,the levels of FIB,D-D,and FDP in the HSPN group were higher than those in the HSP group,the differences were statistically significant (P＜0.05).The levels of urine β2-MG in the HSP group and HSPN group were higher than those in the control group,and the level of urine β2-MG in the HSPN group was higher than that in the HSP group,the differences were statistically significant (P＜0.05).There was a positive correlation between FIB,D-D,and FDP in the plasma of the HSPN group and the renal damage index urine β2-MG (r=0.5655,P＜0.05；r=0.5577,P＜0.05；r=0.3906,P＜0.05).Conclusion The plasma levels of FIB,DD,and FDP in children with HSPN are elevated,and they are positively correlated with the renal damage indicator urine β2-MG.Children with HSPN have abnormalities in the coagulation and fibrinolytic system in the early stages of the disease,which may be involved in the development of renal damage.process. 2020 Vol. 27 (5): 127-130 [Abstract] ( 69 ) HTML (39 KB)  PDF  (0 KB)  ( 15 ) 131 Application effect of half-day outpatient management in patients with gestational diabetes LIANG Jin-jin； LIU Jing-piao； FENG Li-hui； CHEN Mei-jun； CHEN Lu Objective To explore the application effect of half-day outpatient management in patients with gestational diabetes.Methods A total of 200 cases of gestational diabetes patients admitted to our hospital from January to June 2019 were selected as the study subjects.All the included patients were divided into observation group and control group according to the random grouping principle,with 100 cases in each group.The observation group was operated for half-day outpatient management,and the control group was given a nutrition clinic to guide the traditional health education.The blood glucose situation,score of related knowledge,compliance behavior and pregnancy outcome between the two groups were compared.Results The ideal rate of glycemic control in the observation group was higher than that in the control group,and the difference was statistically significant (P ＜0.05).The relevant knowledge acquisition score of the observation group was higher than that of the control group,the pregnancy weight gain was lower than the control group,and the differences were statistically significant (P＜0.05).The compliance behavior of the observation group was better than that of the control group,the difference was statistically significant (P＜0.05).The incidences of abnormal liver function,lipid metabolism and renal dysfunction in the observation group were lower than those in the control group,and cesarean section rate,the incidence of low weight infant and macrosomia were lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Through the management of gestational diabetes for half-day outpatient management,it can effectively improve patient compliance and cooperation,and effectively control the blood glucose of patients,which can effectively reduce the incidence of adverse pregnancy outcomes,and improve the maternal and infant outcomes can be promoted in clinical practice. 2020 Vol. 27 (5): 131-133 [Abstract] ( 72 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 134 Application effect of gonadotropin-releasing hormone agonist in ovulation induction therapy of patients with polycystic ovary syndrome SONG Xiao-xia； SUN Lin▲ Objective To explore application effect of gonadotropin-releasing hormone agonist (GnRHa) in ovulation induction therapy of patients with polycystic ovary syndrome (PCOS).Methods A total of 100 PCOS patients treatedin the hospital from January to December in 2018 were enrolled in the study.They were divided into observation group and control group by random number table method,with 50 cases in each group.The observation group was given Gn-RHa to induce ovulation.The control group was given human chorionic gonadotropin (HCG) for simple ovulation induction therapy.The ovulation induction indexes (days for follicle maturity,number of mature follicles and ovulation rate),levels of estrogen and progestin such as follicle stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E2) and progesterone (P) before and after treatment,incidence of ovarian hyperstimulation syndrome (OHSS),natural pregnancy rate,multiple pregnancy rate,early abortion rateafter treatment,and the incidence of ovarian cysts after treatment in the next menstrual period of non-pregnant patientswere compared between the two groups.Results After treatment,there were no significant differences in days for follicle maturity,number of mature follicles,ovulation ratebetween the two groups (P＞0.05).There were no significant differences in FSH and LH levels between the observation group and the control group after treatment (P＞0.05).The E2 and P levels in the observation group after treatment were lower than those in control group,and the differences were statistically significant (P＜0.05).After treatment,there were no significant differences in natural pregnancy rate,early abortion rate or incidence of cyst between the two groups (P＞0.05).The multiple pregnancy rate and incidence of OHSS in observation group were lower than those in control group,and the differences were statistically significant (P＜0.05).Conclusion GnRHa ovulation induction therapy can reduce the levels of estrogen and progestogen after ovulation without affecting natural pregnancy rate of PCOS infertile patients,and the incidence of OHSS is lower. 2020 Vol. 27 (5): 134-136转139 [Abstract] ( 69 ) HTML (35 KB)  PDF  (0 KB)  ( 13 ) 137 Clinical effect of Metformin combined with Dydrogesterone in the treatment of polycystic ovary syndrome ZHONG Xiu-chang Objective To investigate the clinical effect of Metformin as adjuvant therapy for treatment of patients with polycystic ovary syndrome (PCOS).Methods Thirty patients with PCOS who came to our hospital from March 2015 to June 2017 were selected as subjects of study.They were divided into control group and study group according to the random number table method,15 cases in each group.The control group was treated with Dydrogesterone,while the study group was added with Metformin besides Dydrogesterone.The clinical efficacy,tumor necrosis factor-α (TNF-α),homeostasis model assessment-insulin resistance (HOMA-IR),serum estradiol (E2),follicle stimulating hormone (FSH),testosterone(T),luteinizing hormone(LH),and the occurrence of adverse reactions were compared between the two groups.Results The clinical effective rate of the study group was 93.33%,higher than that of the control group accounting for 60.00%，the difference was statistically significant (P＜0.05).There were no significant differences in HOMA-IR,TNFα,LH,FSH,T and E2 levels between the two groups before intervention (P＞0.05).After intervention,HOMA-IR,TNFα,LH,FSH,T,and E2 level were lower than those before the intervention,and those indexes in study group were lower than those of the control group，the differences were statistically significant (P＜0.05).There was no significant difference in the incidence of adverse reactions between the study group (13.33%) and the control group (20.00%) (P＞0.05).Conclusion Metformin is effective in the treatment of PCOS with Dexamethasone,which can improve IR,inflammatory status and endocrine metabolism in patients. 2020 Vol. 27 (5): 137-139 [Abstract] ( 88 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 140 Effect of hysteroscopic electrotomy in the treatment of infertility of endometrial polyps LI Ji-heng ；YUAN Guang-hui； LIANG Xiao-ming ；LI Yang-yang ；GUAN Kui-hua Objective To observe the effect of hysteroscopic electrotomy in the treatment of infertility of endometrial polyps.Methods A total of 90 cases of infertile patients with endometrial polyps treated in our hospital were selected from January 2017 to June 2018.They were divided into hysteroscopic electrotomy group (45 cases) and hysteroscopic curettage group (45 cases) according to random number table method.Hysteroscopic electrotomy group was treated with electrotomy,hysteroscopic curettage group was treated with curettage.The clinical efficacy,occurrences of vaginal bleeding,recurrence and pregnancy,menstrual volumes and endometrial thickness of the two groups were statistically analyzed.Results The total effective rate of the hysteroscopic hysterectomy group was 97.8% (44/45),higher than that of the hysteroscopic curettage group for 88.9% (40/45) (P＜0.05).The recurrence rate were lower than that of the hysteroscopic curettage group (P＜0.05),the pregnancy rate was higher than that of the hysteroscopic curettage group (P＜0.05),the menstrual volume was less than that of the hysteroscopic curettage group,the differences were statistically significant (P＜0.05).Conclusion Hysteroscopic electrotomy is more effective than curettage in the treatment of infertility with endometrial polyps,so it is worthy of clinical promotion. 2020 Vol. 27 (5): 140-142 [Abstract] ( 71 ) HTML (32 KB)  PDF  (0 KB)  ( 10 ) 143 Effect of Recombinant Human Interferon α-2b on HPV clearance rate and immune function in patients with high-risk cervical HPV infection DING Yan Objective To investigate the effect of Recombinant Human Interferon α-2b on cervical human papillomavirus (HPV) clearance and immune function in patients with high-risk HPV infection.Methods A total of 100 patients with high-risk cervical HPV infection who were admitted to our hospital from February 2018 to March 2019 were selected and were divided into control group and study group according to random number table method,50 cases in each group.The control group received Baofukang Suppository via vagina,and the study group was added with Recombinant Human Interferon α-2b Suppository.The HPV clearance,cervical erosion-like healing,immune function and medication safety were compared between the two groups.Results The total effectiveness rate of HPV clearance in the study group was 88.00%,higher than that of the control group (60.00%),with statistical difference (P＜0.05).The total effectiveness rate of cervical erosion-like healing in the study group was 92.00%,higher than that of the control group(68.00%),with statistical difference (P＜0.05).The levels of interleukin-6 (IL-6) after treatment were higher in the two groups,and the levels of tumor necrosis factor-α (TNF-α) was lower compared with those before treatment.The level of IL-6 in the study group was higher than that in the control group,and the level of TNF-α was lower than that in the control group,with statistical differences (P＜0.05).There was no obvious adverse reaction during the treatment in two groups.Conclusion In the treatment of high-risk HPV infection of the cervix,Recombinant Human Interferon α-2b Suppository can improve the healing of HPV clearance and cervical erosion-like changes，enhance the immune function of the body，and have high safety. 2020 Vol. 27 (5): 143-145 [Abstract] ( 84 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 146 Intervention effect analysis of clinical pharmacists on rational use of adjuvant drugs in orthopedic inpatients LIN Xue-feng； PAN Yan-ting Objective To analyze the interaction effect of clinical pharmacists on rational use of adjuvant drugs in orthopedic inpatients,and to promote the rational use of adjuvant drugs for orthopedic inpatients in our hospital.Methods The medical records of the orthopaedics department of our hospital from January to June 2017 (before the intervention) were selected,and the auxiliary medication orders were specially reviewed.The typical problems found were summarized and measures were taken to intervene.The hospital orders of orthopaedic auxiliary drugs from July to December 2017 (after the intervention) were collected and reviewed.The reasonable utilization rate of auxiliary drugs,the reasonable rate of indications,the reasonable rate of usage and dosage,the reasonable rate of solvent,the reasonable rate of course of treatment and the reasonable rate of combined drugs were used as inspection indicators.The changes of the above indicators before and after the intervention were analyzed,and whether there was statistical significance was analyzed,so as to evaluate the intervention effect.Results Before the intervention,489 medical records of orthopaedics patients were treated with adjuvant drugs,492 medical records of orthopaedics patients were treated with adjuvant drugs after the intervention.After the intervention,the reasonable utilization rate of drugs (85.37%),the reasonable rate of indications (93.09%),the reasonable rate of usage and dosage (95.93%),the reasonable rate of menstruum (93.90%),the reasonable rate of course of treatment (89.84%) and the reasonable rate of combined drugs (94.30%)were all higher than those before the intervention (41.72%,81.60%,83.23%,85.89%,83.64%,85.89%),respectively,with statistically significant differences (P＜0.05).Conclusion After the intervention of clinical pharmacists,the irrational use of auxiliary drugs for orthopedic inpatients in our hospital has been significantly improved,reducing the risks of clinical drug use and the economic burden of patients,and making drug use more rational. 2020 Vol. 27 (5): 146-148转161 [Abstract] ( 79 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 149 Analysis on the role of prescription review in clinical rational drug use ZHEN Ju-quan； WEN Jian-kun Objective To explore the role of prescription review in clinical rational drug use.Methods A total of 2000 outpatient prescriptions in half a year before and after the implementation of the prescription review feedback system in our hospital on June 1,2018 were randomly selected as the research objects,and 1000 before and 1000 after the implementation of the prescription review feedback system.The qualified rate of outpatient prescriptions,the rate of clinical irrational drug use and the related situation of drug prescriptions in half a year before and after the implementation of the prescription review system in our hospital were compared and analyzed.Results The qualified rate of prescriptions after the implementation of the prescription review system was 93.7%,which was higher than 82.6% before the implementation,and the difference was statistically significant (P＜0.05).After the implementation of prescription comment system,the rate of irrational use of drugs was 1.40%,lower than 7.50% after the implementation,and the difference was statistically significant (P＜0.05).After implementation,the medication time was shorter than that before implementation,the type of medication was less than that before implementation,and the medication cost was lower than that before implementation,the differences were statistically significant (P＜0.05).Conclusion Prescription review can effectively improve the quality of clinical medication,improve the standard of prescription writing,avoid the application of unreasonable and unnecessary drugs,and play an active role in promoting clinical rational drug use. 2020 Vol. 27 (5): 149-151 [Abstract] ( 59 ) HTML (32 KB)  PDF  (0 KB)  ( 12 ) 152 Clinical effect of Amlodipine combined with Irbesartan in the treatment of diabetes mellitus complicated with hypertension HE Yin-huan Objective To analyze the clinical effect of Amlodipine combined with Irbesartan in the treatment of diabetes mellitus complicated with hypertension.Methods A total of 100 patients with diabetes mellitus and hypertension admitted to our hospital from January 2015 to June 2017 were selected as the research objects,and divided into observation group and control group according to the way of lottery grouping,with 50 cases in each group.The observation group was treated with Amlodipine combined with Irbesartan,while the control group was treated with conventional therapy.Systolic blood pressure(SBP),diastolic blood pressure(DBP),total effective rate,fasting blood sugar,2-hour postprandial blood sugar level and total incidence of adverse reactions were compared between the two groups.Results After treatment,the SBP and DBP in the observation group were lower than those in the control group (P＜0.05)；the total effective rate in the observation group was higher than that in the control group (P＜0.05)；the levels of fasting blood sugar and 2-hour postprandial blood sugar in the observation group were lower than those in the control group (P＜0.05)；and the total incidence of adverse reactions in the observation group was lower than that in the control group (P＜0.05).Conclusion Amlodipine combined with Irbesartan is effective in the treatment of diabetes mellitus with hypertension. 2020 Vol. 27 (5): 152-154 [Abstract] ( 70 ) HTML (33 KB)  PDF  (0 KB)  ( 13 ) 155 Clinical effect of Metoprolol combined with Nifedipine in the treatment of hypertension WANG Yi-jin； HUANG Lian-di Objective To analyze the clinical effect of Metoprolol combined with Nifedipine in the treatment of hypertension.Methods Sixty patients with hypertension who were admitted to our hospital from June 2014 to May 2019 were selected as subjects.They were divided into control group and observation group according to the odd/even method with 30 cases in each group.In the control group,patients were treated with Nifedipine,and in the observation group,participants were treated with Metoprolol combined with Nifedipine.The diastolic blood pressure and systolic blood pressure levels before and after treatment,as well as the clinical effect and adverse reactions and quality of life after treatment were compared between the two groups.Results The diastolic blood pressure and systolic blood pressure levels of the two groups were lower than those before treatment,and the diastolic blood pressure and systolic blood pressure level in the observation group were lower than those in the control group,the differences were statistically significant (P＜0.05).The total clinical effective rate in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).The quality of life scores after treatment were higher than those before treatment,and the quality of life score of the observation group after treatment was higher than that of the control group with statistical significance (P＜0.05).Conclusion The clinical effect of Metoprolol combined with Nifedipine in the treatment of hypertension is remarkable,which can regulate the blood pressure level and improve the clinical efficacy.Meanwhile,the incidence of adverse reactions of this therapy is low and the treatment safety is high,which is worthy of clinical application. 2020 Vol. 27 (5): 155-157 [Abstract] ( 106 ) HTML (33 KB)  PDF  (0 KB)  ( 3 ) 158 Clinical application effect of Qidong Runfei Decoction combined with Montelukast Sodium on patients with chronic obstructive pulmonary diseases at a stable stage identified as dual deficiency of qi and yin of the lung and kidney ZHANG Cai-lai ；LAN Ri-sheng； LIU Hong-yan Objective To investigate the clinical effect of Qidong Runfei Decoction combined with Montelukast Sodium in the treatment of patients with chronic obstructive pulmonary diseases (COPD) at a stable stage identified as dual deficiency of qi and yin of the lung and kidney.Methods From May 2017 to August 2018,60 patients with COPD at a stable stage identified as dual deficiency of qi and yin of the lung and kidney admitted to our hospital were selected as the observation samples.They were divided into the control group (n=30) and study group (n=30) according to odd/even number in random.Patients in the control group were treated with Montelukast Sodium alone.On the basis of this treatment,Qidong Runfei Decoction was added in the study group.The lung function changes,clinical pattern scores,and COPD assessment test (CAT) scores,6-minute walking distance were compared between the two groups.Results The forced expiratory volume in 1 s (FEV1) and the ratio of the FEV1 to forced vital capacity (FEV1/FVC) in the study group were both higher than those before treatment,the differences were statistically significant (P＜0.05).The FEV1 and FEV1/FVC in the study group were higher than those in the control group,and the differences were statistically significant (P＜0.05).The clinical pattern scores and CAT scores of the two groups after treatment were both lower than those of the two groups before the treatment,the 6-minute walking distance was farther than that of the two groups before the treatment,the differences were statistically significant (P＜0.05).After treatment,the clinical pattern scores and CAT scores in the study group were both lower than those of the control group,and the 6-minute walking distance was farther than that of the control group,the differences were statistically signifi cant (P ＜0.05).Conclusion Qidong Runfei Decoction combined with Montelukast Sodium obtains a good effect on the treatment of stable COPD identified as dual deficiency of qi and yin of the lung and kidney,which can markedly improve patients′ lung function,alleviate their clinical symptoms,and improve their labor endurance and immune function,which is worthy of extensive application in clinical practice. 2020 Vol. 27 (5): 158-161 [Abstract] ( 76 ) HTML (36 KB)  PDF  (0 KB)  ( 15 ) 162 Application of Sodium Hyaluronate combined with Taohong Siwu Decoction and Liuwei Dihuang Pills after rotator cuff repair WAN Yun-feng； CAO Yin-sheng； YI Qiang；WEI Teng-fei； WEN Meng Objective To investigate the application of Sodium Hyaluronate combined with Taohong Siwu Decoction and Liuwei Dihuang Pills after rotator cuff repair.Methods Seventy patients with rotator cuff tear treated in our hospital from September 2017 to December 2018 were selected as the research objects,they were divided into control group and a test group according to a random drawing method,with 35 cases in each group.The control group was injected with Sodium Hyaluronate after rotator cuff repair.The test group was given oral Taohong Siwu Decoction combined with Liuwei Dihuang Pills on the basis of the control group,7 days was a course of treatment,and there were two courses.The visual analogue scale (VAS) score,the Constant-Murley score of the shoulder joint,and the passive movement were compared between the two groups before and after surgery half a month,1 and 3 months.Results Before surgery,there were no significant differences in VAS,Constant-Murley scores and passive activity between the two groups (P＞0.05).The VAS scores in the test group for half a month after operation was lower than that in the control group,and the Constant-Murley scores in the half and one and three months after operation were higher than those in the control group,and the differences were statistically significant (P＜0.05).In the test group,the degree of passive internal rotation was greater than that of the control group in the first half of the month,the degree of passive flexion and internal rotation were greater than those of the control group in the first month,the active flexion,passive external rotation and passive internal rotation activities at 3 months after operation were greater than those of the control group,differences were statistically significant (P＜0.05).Conclusion Sodium Hyaluronate combined with Taohong Siwu Decoction and Liuwei Dihuang Pills after rotator cuff repair can effectively improve the pain and shoulder function of patients,it is worthy of clinical application. 2020 Vol. 27 (5): 162-165转169 [Abstract] ( 79 ) HTML (41 KB)  PDF  (0 KB)  ( 11 ) 166 Clinical effect of Dachengqi Decoction for enema in the treatment of critically ill patients with gastrointestinal dysfunction GUO Dong-wei ；ZHU Jun-bao ；ZHANG Peng-fei ；LUO Le； LI Su-shu； ZHANG Hua-ling ；HE Zhi-qun Objective To explore the clinical effect of Dachengqi Decoction for enema in the treatment of critically ill patients with gastrointestinal dysfunction.Methods A total of 76 critically ill patients with gastrointestinal dysfunction admitted to Respiratory Intensive Care Unit(RICU) of Liuzhou Traditional Chinese Medical Hospital from March 2017 to March 2019 were selected as study objects.The patients were divided into control group (38 cases) and observation group (38 cases) according to the random number table method.The control group received routine treatment,while the observation group received Dachengqi Decoction for enema on the basis of routine treatment.The clinical efficacy and recovery of gastrointestinal function in two groups of patients were observed.The scores of acute physiological and chronic health (APACHE Ⅱ) and gastrointestinal dysfunction were compared between the two groups of patients before and after treatment.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The recovery time of bowel sound,the time of first exhaust of the anus,the time of the first defecation,and the time of beginning enteral nutrition in the observation group were shorter than those in the control group,and the differences were statistically significant (P＜0.05).There were no significant differences in scores of APACHE Ⅱand gastrointestinal dysfunction between the two groups before treatment (P＞0.05).After treatment,the scores of APACHE Ⅱand gastrointestinal dysfunction in the observation group were lower than those in the control group,and the differences were statistically significant (P＜0.05).Conclusion Dachengqi Decoction for enema treatment can improve gastrointestinal function in critically ill patients,promote early recovery of gastrointestinal function,and reduce APACHE Ⅱscore. 2020 Vol. 27 (5): 166-169 [Abstract] ( 74 ) HTML (36 KB)  PDF  (0 KB)  ( 8 ) 170 Effect and safety of Amitriptyline Aydrochloride Tablets combined with self-made traditional Chinese medicine decoction in the treatment of tension-type headache LIAN Jie；YANG Yu-feng Objective To investigate the effect and safety of Amitriptyline Hydrochloride Tablets combined with selfmade traditional Chinese medicine decoction in the treatment of tension-type headache.Methods A total of 150 patients with tension-type headache who were admitted to the Second People′s Hospital of Dalian from March 2017 to March 2019 were enrolled.The patients were divided into intervention group (75 cases) and control group (75 cases)according to the random number table method.The control group was treated with Amitriptyline Hydrochloride Tablets,and the intervention group was treated with Amitriptyline Hydrochloride Tablets and self-made traditional Chinese medicine decoction.The effect of treatment,headache and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the intervention group was higher than that in the control group,and the difference was statistically significant (P＜0.05).The degree of headache and total adverse reaction rate in the intervention group were lower than those in the control group,the differences were statistically significant (P＜0.05).Conclusion The combination of Amitriptyline Hydrochloride Tablets and self-made traditional Chinese medicine decoction can alleviate the headache degree of patients with tension-type headache,improve the therapeutic effect,and has high safety. 2020 Vol. 27 (5): 170-172 [Abstract] ( 71 ) HTML (33 KB)  PDF  (0 KB)  ( 11 ) 173 Clinical effect of Bushen Tiaozhou method in the treament of puberty dysfunctional uterine bleeding identified as a kidney yin deficiency pattern SONG Min Objective To explore the clinical effect of Bushen Tiaozhou method in the treament of puberty dysfunctional uterine bleeding identified as a kidney yin deficiency pattern.Methods A total of 94 patients with puberty dysfunctional uterine bleeding identified as a kidney yin deficiency pattern admitted to our hospital from June 2014 to June 2018 were selected as the study subjects.The patients were divided into control group and observation group by random number table method,with 47 cases in each group.Patients in the control group were treated with conventional Western medicine.In the observation group,on the basis of the control group,Bushen Tiaozhou method was added.After three menstrual cycles,the treatment effect,menstrual period and adverse reactions were compared between the two groups.The follow-up period was six months,and the long-term efficacy was compared between the two groups.Results The total short-term treatment effectiveness was 95.74% in the observation group,compared with 91.49% in the control group,with no statistically significant difference (P＞0.05).The total long-term treatment effectiveness rate in the observation group (91.49%) was higher than that in the control group (72.34%),the difference was statistically significant (P＜0.05).After treatment,the menstrual period of the observation group was (5.08±0.87) d,which was shorter than that of the control group of (6.39±1.36) d,the difference was statistically significant (P＜0.05).The overall incidence of adverse reactions in the observation group was 6.38%,with no statistically significant difference compared with 10.64% in the control group (P＞0.05).Conclusion Bushen Tiaozhou method in the treatment of puberty dysfunctional uterine bleeding identified as a kidney yin deficiency patternis can effectively improve the clinical symptoms of patients,enhance long-term efficacy,and promote menstrual recovery in great safety. 2020 Vol. 27 (5): 173-176 [Abstract] ( 80 ) HTML (35 KB)  PDF  (0 KB)  ( 12 ) 177 Blood routine characteristics of inflammatory bowel disease and its significance GUAN Xi-hua Objective To investigate the blood routine characteristics of inflammatory bowel disease and its significance.Methods From February 2018 to April 2019,50 patients with inflammatory bowel disease treated in our hospital were selected as the observation group,and 50 patients with non-inflammatory bowel disease in the same period were selected as the control group.The routine blood test indexes such as blood platelet count (PLT),mean platelet volume (MPV),concentration of hemoglobin (HGB),average red blood cell volume (MCV),red blood cell hemoglobin concentration (MCHC),C-reactive protein (CRP),red blood cell distribution width (RDW) and erythrocyte sedimentation rate of the two groups were compared.Results The PLT,RDW,CRP and erythrocyte sedimentation rate in the observation group were higher than those in the control group,and MPV,HGB,MCV and MCHC were lower than those in the control group,with statistically significant differences (P＜0.05).In the observation group,PLT,RDW,CRP and erythrocyte sedimentation rate of patients in remission were lower than those of patients with mild,moderate and severe symptoms,with statistically significant differences (P＜0.05).The MPV,HGB,MCV and MCHC of patients in remission were higher than those of patients with mild,moderate and severe diseases,with statistically significant differences (P＜0.05).The PLT,RDW,CRP and erythrocyte sedimentation rate of patients in mild symptoms were lower than those of patients with moderate and severe symptoms,the HGB was higher than that of patients with moderate and severe symptoms,with statistically significant differences (P＜0.05).The PLT,RDW,CRP and erythrocyte sedimentation rate of patients in moderate symptoms were lower than those of patients with severe symptoms,the HGB was higher than that of patients with severe symptoms,with statistically significant differences (P＜0.05).Conclusion Routine blood test in the diagnosis process of inflammatory bowel disease can not only clarify the diagnosis of the disease,but also help to determine the severity of the disease,which has a high reference value for the treatment of the disease. 2020 Vol. 27 (5): 177-180 [Abstract] ( 63 ) HTML (34 KB)  PDF  (0 KB)  ( 15 ) 181 Value of combined detection of serum fibrinogen,C-reactive protein and blood routine in the diagnosis of bacterial pneumonia WANG Ling Objective To analyze the value of combined detection of serum fibrinogen,C-reactive protein (CRP) and blood routine in the diagnosis of bacterial pneumonia.Methods A total of 220 patients suspected with bacterial pneumonia admitted to our hospital from June 1,2018 to June 1,2019 were selected as research objects.All patients received serum fibrinogen,CRP and blood routine joint detection.The positive detection rate,sensitivity,specificity and accuracy of different detection methods were counted,and the diagnostic value of different detection methods was compared.Results In the 220 patients,202 cases were confirmed by pathology.The positive detection rate of serum fibrinogen in patients was 70.91%,the positive detection rate of CRP was 67.27%,the positive detection rate of routine blood test was 65.45%,and the positive detection rate of combined detection was 87.27%.The sensitivity,specificity and accuracy of combined detection were higher than those of single detection,the differences were statistically significant(P＜0.05).The sensitivity,specificity and accuracy of serum fibrinogen,CRP and blood routine detection were not statistically significant (P＞0.05).Conclusion The combined detection of serum fibrinogen,CRP and routine blood test can provide reference for the diagnosis of bacterial pneumonia. 2020 Vol. 27 (5): 181-183 [Abstract] ( 63 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 184 Application value of glycated hemoglobin combined with fasting blood glucose in the screening of early gestational diabetes mellitus CHEN Ying ；QIU Xiao-jun Objective To explore the application value of glycated hemoglobin (HbA1c) combined with fasting blood glucose (FPG) in the screening of early gestational diabetes mellitus (GDM).Methods A total of 64 patients with GDM diagnosed in the obstetrics and gynecology department of our hospital from January 2017 to July 2018 were selected as the GDM group,and 64 healthy pregnant women who underwent routine birth examination in our hospital during the same period were selected as the control group.Both groups were tested for HbA1c and oral glucose tolerance test(OGTT).FPG,HbA1c and OGTT were compared between the two groups.The area under curve (AUC),sensitivity,specificity and accuracy of different indexes were compared.Results The levels of FPG,HbA1c and OGTT in the GDM group at 1 and 2 hours after taking glucose were higher than those in the control group,the differences were statistically significant (P＜0.05).The receiver operating characteristic (ROC) AUC of subjects with combined detection of FPG and HbA1c in the diagnosis of GDM were higher than those of the two alone,the differences were statistically significant (P＜0.05).The sensitivity,specificity and accuracy of the combined detection of FPG and HbA1c in the diagnosis of GDM were higher than those of the two alone,the differences were statistically significant (P＜0.05).Conclusion The combined use of HbA1c and FPG in the diagnosis of GDM has higher diagnostic efficacy,and has guiding significance for early screening of patients with GDM. 2020 Vol. 27 (5): 184-186 [Abstract] ( 70 ) HTML (31 KB)  PDF  (0 KB)  ( 15 ) 187 Role of nurse hierarchical management mode in improving the quality of nursing management WU Hong-hong； HU Min-hua ；ZHOU Zhi-jin Objective To discuss the role of nurse hierarchical management mode in improving the quality of nursing management.Methods A total of 100 cases of internal medicine from January to June 2017 were selected for the before implementation group,and 100 cases from July to December 2017 for the after implementation group.A total of 24 nurses were involved.Before implementation,routine nursing management mode and nursing method were adopted,and nurse hierarchical management mode was adopted after implementation.Patients′ total nursing satisfaction,total incidence of adverse events,nurses′ nursing quality,nurses′ professional knowledge score and nursing operation score were compared before and after implementation.Results The scores of basic nursing,ward nursing and quality nursing in the after implementation group were higher than those before implementation group,and the differences were statistically significant (P＜0.05).After the implementation group,nurses′ professional knowledge score and nursing operation score were higher than those before the implementation group,the differences were statistically significant (P＜0.05).After the implementation group,the total incidence of adverse events was lower than that before implementation group,and the difference was statistically significant (P＜0.05).Patients′ total satisfaction after implementation group was higher than that of before implementation group (P＜0.05).Conclusion The nurse hierarchical management mode can significantly improve the quality of nursing,improve patient satisfaction and reduce the incidence of nursing adverse events. 2020 Vol. 27 (5): 187-189 [Abstract] ( 82 ) HTML (31 KB)  PDF  (0 KB)  ( 13 ) 190 Application of continuous quality improvement in the management of high risk drugs in obstetrics and gynecology CHEN Xue-xia Objective To evaluate the application value of continuous quality improvement in the management of highrisk drugs in obstetrics and gynecology.Methods The time before continuous quality improvement was set from February 2016 to February 2017,and the time from March 2017 to March 2018 was set as after improvement.The frequency of high-risk drug management defects before and after continuous quality improvement were recorded.Results The management of high-risk drugs in the gynecology and obstetrics ward was checked for 48 times,with 336 times recorded in total.The total frequency of defects before improvement was 110 times,higher than that after improvement for 16 times,which was statistically significant (P＜0.05)；after continuous quality improvement,the incidence rates of drugs mixed (0.06%),lack of identification (0.00%),the base number not supplemented in time (1.79%),management not standardized (1.79%),no professional management (0.00%),shift handover not carried out Unscientific (0.00%),poor management risk awareness (0.06%) were lower than before (4.76%,3.57%,5.95%,7.14%,2.38%,2.98%,5.95%),the differences were statistically significant (P＜0.05).The awareness of nurses after the improvement was 85.71%,higher than 47.61% after the improvement,and the difference was statistically significant (P＜0.05).Conclusion In the management of high-risk drugs in obstetrics and gynecology,the effect of continuous quality improvement is significant,which can improve the safety level of high-risk drug management,enhance the drug safety of patients,and improve the defects of high-risk drug management. 2020 Vol. 27 (5): 190-192转196 [Abstract] ( 69 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 193 Application effect of continuous quality improvement in hospital infection management WANG Chang-jun Objective To explore the application value of continuous quality improvement in hospital infection management.Methods Eighty-two patients admitted to our hospital from January 2015 to November 2017 were enrolled in the study.They were randomly divided into control group (n=41) and observation group (n=41).The control group was given routine management,and the observation group was given continuous quality improvement.The satisfaction,management quality and total infection rate of the two groups were compared.Results The total satisfaction of the observation group with hospital infection management (97.6%) was higher than that of the control group (78.0%),and the total incidence of infection (4.8%) was lower than that of the control group (24.4%),with statistically significant differences(P＜0.05).The scores of disinfection and isolation,hand hygiene,medical guidance and supervision in the observation group were all higher than those in the control group,with statistically significant differences (P＜0.05).The total score of management quality in the observation group was (91.1±2.1) points,which was higher than that in the control group of (74.9±2.1) points,with statistically significant difference (P＜0.05).Conclusion Continuous quality improvement can improve the satisfaction of hospitalized patients and the quality of management work,and can also reduce the risk of hospital infection,and its application value is high. 2020 Vol. 27 (5): 193-196 [Abstract] ( 74 ) HTML (34 KB)  PDF  (0 KB)  ( 16 ) 197 Effect of modified blood collection technique by rapid small angle direct puncture on the quality of blood samples JIANG Chun-ying； ZHANG Hua-xiu； XU Liang； WANG Xiao-feng； YI Hong-yu ；HU Lin Objective To explore the effect of modified blood collection technique by rapid small angle direct puncture on the quality of blood samples.Methods From January to December 2018,1 261 281 blood samples were collected in our hospital by rapid small angle direct puncture method,and 1 038 025 blood samples were collected by routine blood collection technique in a third class A hospital in the province at the same time.The hemolysis rate of the samples and the proportion of the test results in accordance with the clinical symptoms were compared between the two hospitals.Results The hemolysis rate of blood collection in our hospital was 0.0017% (22/1 261 281),which was lower than that in a third class A hospital in the province (0.1644%,1706/1 038 025),and the difference was statistically significant(P＜0.01).Only 7 cases (0.000 55%) did not conform to the clinical symptoms in the examination results of blood samples in our hospital,while 39 cases (0.003 76%) in a third class A hospital in the province was not in accordance with the clinical symptoms,the difference was statistically significant (P＜0.01).Conclusion The blood collection procedure is closely related to the quality of the specimen.The use of rapid small angle direct puncture and modified blood collection details in our hospital can reduce the hemolysis rate of the blood sample and improve the quality of blood samples,which is worth popularizing in the clinical nursing work. 2020 Vol. 27 (5): 197-199 [Abstract] ( 80 ) HTML (35 KB)  PDF  (0 KB)  ( 14 ) 200 Development and application of ″Z″ support,hand and axillary cushion for lateral and lateral prone position in brain surgery ZHENG Li-fang； GAO Yuan-yan； YANG Qiong ；LIANG Jin-yu Objective To investigate the feasibility,practicability and science of hand,axillary body pad and Z-shaped bracket in neurosurgery.Methods From September 2017 to August 2018,60 patients undergoing neurosurgery in our hospital were selected and randomly divided into control group and observation group,30 cases in each group.The control group was given routine method (traditional lateral lying,lateral prone position placement).The observation group was given lateral lying,lateral prone position ″Z″ support,hand,axillary body pad,and nursing intervention was strengthened to compare the injury rate between the two groups.Results The total incidence of body injury in the observation group was 3.33%,which was lower than that in the control group (30.00%),the difference was statistically significant (P＜0.05）.Conclusion Z-shaped support and hand,axillary body pad for lateral and lateral prone position have good practical value in neurosurgery. 2020 Vol. 27 (5): 200-202 [Abstract] ( 60 ) HTML (32 KB)  PDF  (0 KB)  ( 13 ) 203 Application effect of holistic nursing in perioperative period of laparoscopic surgery for ectopic pregnancy YANG Gui-xia； XU Yu-fang Objective To discuss the application effect of holistic nursing in the perioperative period of laparoscopic surgery for ectopic pregnancy patients.Methods Sixty patients with ectopic pregnancy received in our hospital from January 2018 to June 2019 were selected as the subjects of study.They were divided into routine group and intervention group according to lottery method,30 cases in each group.Routine nursing was applied in the routine group,and holistic nursing was applied in the intervention group on the basis of routine nursing.Anxiety,depression score,total incidence of complications and nursing total satisfaction were compared between the two groups.Results After intervention,the scores of anxiety and depression in intervention group were lower than those in routine group,and the differences were statistically significant (P＜0.05)；the total complication rate of the intervention group was lower than that of the routine group,the difference was statistically significant (P＜0.05)；the nursing total satisfaction of the intervention group was higher than that of the routine group,the difference was statistically significant (P＜0.05).Conclusion The holistic nursing intervention for patients with ectopic pregnancy during perioperative period can effectively alleviate their bad mood and reduce the occurrence of complications,thus improving nursing satisfaction,which is worthy of clinical promotion. 2020 Vol. 27 (5): 203-205 [Abstract] ( 61 ) HTML (32 KB)  PDF  (0 KB)  ( 11 ) 206 Effect of evidence-based nursing on deep vein thrombosis formation after hepatectomy WU Na Objective To investigate the effect of evidence-based nursing (EBN) on formation of deep vein thrombosis(DVT) after hepatectomy.Methods A total of 120 patients undergoing hepatectomy in the hospital from April 2017 to April 2019 were selected.They were divided into control group (n=60) and observation group (n=60) by random number table methods.The control group was given routine nursing,while observation group was given EBN on basis of routine nursing.The incidence of lower limbs dropsy and DVT,depression and anxiety,evaluation on quality of life,and patient satisfaction score were compared between the two groups.Results The incidence rates of lower limbs dropsy and DVT in observation group were 6.67% and 1.67%,lower than those in control group (20.00%,8.33%) (P＜0.05).After nursing intervention,scores of depression and anxiety in observation group were lower than those in control group (P＜0.05).After nursing intervention,score of quality of life in observation group were higher than those in control group(P＜0.05).The patients′ satisfaction score in observation group was higher than that in control group,the differences were statistically significant (P＜0.05).Conclusion EBN can effectively prevent formation of DVT after hepatectomy,significantly reduce degree of depression and anxiety,improve their quality of life,and improve their satisfaction. 2020 Vol. 27 (5): 206-209 [Abstract] ( 57 ) HTML (37 KB)  PDF  (0 KB)  ( 13 ) 210 Application effect of comprehensive nursing in the treatment of uterine prolapse with traditional Chinese medicine fumigation and washing combined with warm acupuncture XIE Jie-lan ；LUO Zhao-qin； CUI Ru-juan； LI Yang-qun； LIN Ming-xia Objective To explore the application effect of comprehensive nursing in the treatment of uterine prolapse by fumigation and washing with traditional Chinese medicine combined with warm acupuncture and moxibustion.Methods A total of 60 patients with uterine prolapse admitted to our hospital from February 2018 to February 2019 were selected as research objects and randomly divided into control group and observation group,30 cases in each group.Both groups received traditional Chinese medicine fumigation combined with warm acupuncture and moxibustion treatment,on the basis of this,the control group received conventional nursing intervention,observation group received comprehensive nursing intervention.The self-rating anxiety scale (SAS) score,self-rating depression scale (SDS) score and total nursing satisfaction were compared between two groups.Results The SAS and SDS scores in the observation group were lower than those in the control group,with statistical differences (P＜0.05).The total nursing satisfaction of the observation group was 96.7%,higher than that of the control group′s 80.0%,the difference was statistically significant (P＜0.05).Conclusion Comprehensive nursing in traditional Chinese medicine fumigation and washing combined with warm acupuncture and moxibustion treatment of uterine prolapse,its application effect is significant,can significantly improve the psychological state of patients,improve the satisfaction of patients with nursing,it is worth promoting in clinical application. 2020 Vol. 27 (5): 210-212 [Abstract] ( 68 ) HTML (30 KB)  PDF  (0 KB)  ( 13 ) 213 Application effect of smartphone-based continuous management in stroke patients combined with diabetes mellitus LYU Xue-yang； QI Li-li； QI Li-na； ZHANG Jing； WANG Yu-ying Objective To explore the application effect of smartphone-based continuous management in stroke (CAV)patients combined with diabetes mellitus (DM).Methods A total of 110 cases of CAV patients combined with DM treated in Hongqi Hospital Affiliated to Mudanjiang Medical University from January to December 2018 were selected as the research objects.The patients were divided into control group and observation group according to random number table method,55 cases in each group.The control group was given routine management after discharge.The observation group was adopted the continuous management mode based on smartphone.After 3 months,the patients′ neurological function recovery,daily living ability and blood glucose control were compared.Results The neurological function score of the observation group was lower than that of the control group,and the daily living ability score was higher than that of the control group,with statistical differences (P＜0.05).Fasting blood glucose (Glu),2 h postprandial blood glucose and glycosylated hemoglobin (GHb) levels in the observation group were lower than those in the control group,with statistical differences (P＜0.05).Conclusion Continuous management for CAV patients combined with DM promotes the recovery of neurological function and improves the living ability of patients,and facilitates the control and stability of blood glucose,with significant effect. 2020 Vol. 27 (5): 213-215 [Abstract] ( 64 ) HTML (33 KB)  PDF  (0 KB)  ( 18 ) 216 Application effect of high quality nursing in upper gastrointestinal endoscopy ultrasonography CHEN Rui-na； LI Gui-bao； PENG Ying-hua； ZENG Xiao-li ；XIE Zhi-gang Objective To explore the application effect of high quality nursing in upper gastrointestinal endoscopy ultrasonography (EUS).Methods One hundred patients with upper gastrointestinal EUS from April 2017 to February 2019 were selected as subjects of study.They were divided into control group and observation group according to the date of examination.The control group received general routine nursing and the observation group was given high quality nursing.Incidence of adverse reactions,coordination and patient total satisfaction of two groups were compared.Results The proportion of suspended operation,pharyngeal mucosal injury and pharyngeal pain in the observation group was lower than that in the control group,and the differences were statistically significant (P＜0.05).The total fit of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).The total satisfaction of the observation group was higher than that of the control group,and the difference was statistically significant (P＜0.05).Conclusion The use of high quality nursing in upper gastrointestinal EUS can promote the cooperation of patients,ensure the successful completion of the examination,reduce pharyngeal mucosal damage,reduce the occurrence of sore throat and improve patient satisfaction. 2020 Vol. 27 (5): 216-218 [Abstract] ( 75 ) HTML (29 KB)  PDF  (0 KB)  ( 14 ) 219 Application effect of Doula labor analgesia combined with whole-process accompanying painless labor in the delivery of elderly parturients XIE Shui-xuo； LIANG Hui-lan； LIANG Ju Objective To investigate the application effect of Doule labor analgesia combined with whole-process accompanying painless labor in the delivery of elderly parturients.Methods A total of 70 cases of primary mothers who were expecting to give birth in our hospital from January to December 2018 were selected as research objects,and divided into observation group (n=36) and the control group (n=34) according to random number table method.The observation group used Dolol analgesia combined with painless delivery,while the control group used traditional delivery methods.The first,second and third,total labor duration,pain scale (PPI) score,self-rating depression scale (SDS)score,self-rating anxiety scale (SAS) score and maternal outcome (postpartum hemorrhage,puerperal infection,neonatal asphyxia,fetal distress) were compared between the two groups.Results The first,second,third and total labor duration of the observation group was shorter than that of the control group,the PPI scores of the first,second and third labor duration were lower than those of the control group,and the SDS and SAS scores were lower than those of the control group,with statistical differences (P＜0.05).The incidence of postpartum hemorrhage,puerperal infection,neonatal asphyxia and fetal distress in the observation group was lower than that in the control group,with statistical differences(P＜0.05).Conclusion The combination of Doula labor analgesia and whole-process accompanied painless labor can significantly shorten the length of labor,reduce the pain degree,improve maternal depression,anxiety and other negative emotions,and reduce the incidence of adverse maternal and infant outcomes such as postpartum hemorrhage,puerperal infection,neonatal asphyxia and fetal distress. 2020 Vol. 27 (5): 219-221转225 [Abstract] ( 78 ) HTML (36 KB)  PDF  (0 KB)  ( 13 ) 222 Influence of the individualized guidance on the maintenance effect of the autoimmune fistula in diabetic nephrotic dialysis patients LIU Wan-shan； LI Ying-na ；LIU Hui-yu ；JIANG Yan-qiong ；LI Yue-ming； LIU Xue Objective To explore the influence of personalized guidance on the use of arteriovenous fistula in patients with diabetic nephropathy (DN) on maintenance hemodialysis (MHD) in nurse clinic.Methods A total of 60 patients with DN on MHD in our center from February 2017 to August 2018 participated in this study.They were randomly divided into two groups,including control group (n=30) with routine care and observation group (n=30) with personalized guidance.Time to maturity for fistula,and complication (fistula obstruction,fistula stenosis,and thrombosis)were observed during this study.Results Time to maturity for fistula was shorter in observation group than that in control group (P＜0.01),and the total incidence of complications in observation group was lower than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Arteriovenous fistula is an important guarantee for DN patients to undergo MHD.Personalized guidance in the nurse clinic helps to shorten time to maturity and decrease total incidence of complications. 2020 Vol. 27 (5): 222-225 [Abstract] ( 71 ) HTML (35 KB)  PDF  (0 KB)  ( 14 ) 226 Application effect of interactive standard theory nursing intervention in patients with biphasic affective disorder GUO Jing Objective To explore the application effect of interactive standard theory in the nursing of patients with bipolar disorder (BP).Methods A total of 96 patients with BP admitted to our hospital from December 2017 to December 2018 were selected as research objects.They were divided into the research group and the reference group according to the admission time,48 cases in each group.Patients in the reference group were given nursing intervention in the conventional mode,while the research group was given nursing intervention using the interactive standard theory.The quality of life and disease knowledge of the two groups of patients before and after the intervention were compared,and the medication compliance and nursing satisfaction were investigated and compared.Results Before the intervention,there were no significant differences in quality of life score and disease knowledge awareness score between the two groups (P＞0.05).After the intervention,the scores of life quality and knowledge of disease knowledge of the two groups were higher than those before intervention and the scores of quality of life and awareness of disease knowledge in the research group were higher than those in the reference group,the differences were statistically significant (P＜0.05).The drug compliance and nursing satisfaction in the research group were 93.75% and 95.83% respectively,which were higher than those in the reference group (77.08%,82.5%),the differences were statistically significant (P＜0.05).Conclusion The application of interactive standard theory to nursing intervention in patients with BP can improve the compliance of drug use and the correct cognition of the disease,so as to improve the quality of life and nursing satisfaction of patients,which is worthy of clinical promotion. 2020 Vol. 27 (5): 226-228 [Abstract] ( 66 ) HTML (30 KB)  PDF  (0 KB)  ( 14 ) 229 Application effect of psychological nursing intervention in patients with depression SU Ting； ZHANG Di-ying Objective To explore the application effect of psychological nursing intervention in patients with depression.Methods A total of 80 newly hospitalized patients from February 2018 to January 2019 in a third-class A hospital in Chongqing were selected as the study subjects.According to the random grouping method,they were divided into experimental group (40 cases) and control group (40 cases).The control group was given routine treatment and nursing,the experimental group being on the basis of the control group,addeds with additional psychological intervention measures (creating good nurse-patient relationship,professional psychotherapy,step training,collective psychotherapy),the degree of depression before and after nursing and the effect after nursing were compared.Results The degree of depression after nursing in the experimental group was lighter than that in the control group,and the difference was statistically significant (P＜0.05).The total effective rate of the experimental group was higher than that of the control group,the difference was statistically significant (P＜0.05).Conclusion Psychological intervention can alleviate depressive symptoms,hospitalized patients need to be paid attention to their mental health,and be strengthen the psychological nursing intervention for the patients with depression,improving the mental status,being helped to recover at an early date. 2020 Vol. 27 (5): 229-231 [Abstract] ( 72 ) HTML (32 KB)  PDF  (0 KB)  ( 8 ) 232 Application effect of detailed quality nursing in patients with ischemic stroke YU Jia Objective To explore the application effect of detailed quality nursing in patients with ischemic stroke(CIS).Methods A total of 80 cases with CIS admitted in our hospital from April 2018 to February 2019 were selected as research objects and divided into observation group (40 cases) and control group (40 cases) according to random number table method.The control group received routine nursing intervention,while the observation group received detailed quality nursing in this study.All the participants were followed up for 3 months.The compliance in the two groups during the intervention process was compared.The scores of anxiety and depression in the two groups before and after the intervention were counted.The recovery of neurological function and living ability in the two groups before and after the intervention were compared.Results The total compliance of the observation group was 97.5%,which was higher than 77.5% of the control group,and the difference was statistically significant (P＜0.05).The Hamilton depression scale(HAMD) and Hamilton anxiety scale (HAMA) scores of the observation group after intervention were lower than those of the control group,and the differences were statistically significant (P＜0.05).The European stroke scale（ESS）and Barthel index in the observation group after intervention were higher than those in the control group and the differences were statistically significant (P＜0.05).Conclusion For patients with CIS,detailed quality nursing can effectively improve the compliance of patients,improve negative psychological status,promote the recovery of neurological function and improve the quality of life. 2020 Vol. 27 (5): 232-234转238 [Abstract] ( 78 ) HTML (34 KB)  PDF  (0 KB)  ( 4 ) 235 Effect of seamless nursing on negative emotions and adverse events in patients with unstable angina pectoris LIU Guang-jie Objective To explore the application value of seamless nursing in patients with unstable angina pectoris.Methods A total of 92 patients with unstable angina pectoris who were treated in our hospital from January 2017 to January 2019 were enrolled.All patients were divided into control group and observation group according to the random number table method,46 cases in each group.The control group received routine nursing intervention and the observation group received seamless nursing intervention.The negative emotions,total adverse events and quality of life were compared between the two groups.Results The scores of self-rating depression scale (SDS) post-intervention and selfrating anxiety scale (SAS) in the observation group were (42.86±3.17) and (40.22±4.56) points,respectively,which were lower than those of the control group for (61.47±6.31) and (54.43±5.50) points,the differences were statistically significant（P＜0.05）.The total incidence of adverse events in the observation group was 10.87%,which was lower than that in the control group (32.61%),the difference was statistically significant (P＜0.05).Activities,activities,recent support,health,general mentality,and total index scores were (1.68±0.22),(1.89±0.37),（1.67±0.35），(1.63±0.52),(1.90±0.25)and (8.66±1.88) points respectively,which were higher than the control group for (1.55±0.35),(1.52±0.53),(1.38±0.46),(1.33±0.50),(1.64±0.45),(7.15±2.00) points,the differences were statistically significant (P＜0.05).Conclusion Seamless nursing intervention can effectively reduce the negative emotions of patients with unstable angina,reduce the incidence of adverse events,improve the quality of life of patients,and benefit patients′ prognosis. 2020 Vol. 27 (5): 235-238 [Abstract] ( 86 ) HTML (33 KB)  PDF  (0 KB)  ( 12 ) 239 Effect of hospital-community-family rehabilitation nursing model on hemiplegic patients with acute cerebral infarction XU Hong； XIN Yu-ying； YIN Hong-xia； WANG Ying-li； WANG Xiao-feng； TAN Yong-jing Objective To explore the effect of hospital-community-family rehabilitation nursing model on hemiplegic patients with acute cerebral infarction.Methods Ninety-eight hemiplegic patients with acute cerebral infarction admitted to Dalian Central Hospital from February 2018 to February 2019 were selected and divided into two groups by random number table method,with 49 in each group.The control group implemented routine nursing intervention,and the study group implemented the hospital-community-family rehabilitation nursing model for a period of 6 months.The psychological status,neurological function and daily living ability of the two groups before and after 6 months nursing were compared.Results There were no significant differences between the two groups in the pre-nursing self-rating depression scale (SDS),the self-rating anxiety scale (SAS),the National Institutes of Health stroke scale (NIHSS),and the Barthel index (BI) scores (P＞0.05).After nursing,the SDS score,SAS score and NIHSS score of the study group were (41.19±7.02),(40.57±7.66),and (6.05±2.29) points,which were lower than those of the control group for (45.82±8.35),(45.27±7.82),(7.78±2.82) points；the BI score of the study group was (74.31±9.11) points,which was higher than that of the control group for (69.07±8.54) points,the differences were statistically significant（P＜0.05）.Conclusion The hospital-community-family rehabilitation nursing model is conducive to improving the psychological state of hemiplegic patients with acute cerebral infarction,promoting the recovery of neurological function and improving their daily living ability.It is worthy of popularization and application. 2020 Vol. 27 (5): 239-242 [Abstract] ( 69 ) HTML (38 KB)  PDF  (0 KB)  ( 8 ) 243 Application effect of quality nursing in lung cancer patients HAN Yang Objective To explore the application effect of quality nursing measures in patients with lung cancer.Methods A total of 100 patients with lung cancer in Fushun Central Hospital from March 2017 to March 2019 were selected as subjects.The patients were divided into control group and observation group by random number table method,with 50 cases in each group.The patients in the control group were given routine nursing.On this basis,quality nursing was given to the observation group.The Zung self-rating anxiety scale (SAS) score,Zung self-rating depression scale (SDS) score,incidence of digestive tract reaction,incidence of skin mucosal injury,incidence of myelosuppression,and nursing compliance scores and overall satisfaction with care between two groups were compared.Results The SAS score of the observation group ([41.12±5.82]points) was lower than that of the control group ([49.87±6.68]points),the difference was statistically significant (P＜0.05).The SDS score of the observation group ([40.59±6.68]points) was lower than that of the control group ([48.81±8.83]points),the difference was statistically significant (P＜0.05).The incidence of digestive tract reaction in the observation group (64.00%) was lower than that in the control group(82.00%),and the difference was statistically significant (P＜0.05).The incidence of skin mucosal injury in the observation group (42.00%) was lower than that in the control group (66.00%),the difference was statistically significant (P＜0.05).The incidence of myelosuppression in the observation group (46.00%) was lower than that in the control group(78.00%),the difference was statistically significant (P＜0.05).The compliance score of the observation group ([94.68±5.16]points) was higher than that of the control group ([86.62±5.51]points),and the difference was statistically significant (P＜0.05).The total satisfaction of nursing patients in the observation group (98.00%) was higher than that in the control group (84.00%),and the difference was statistically significant (P＜0.05).Conclusion Applying quality nursing to the nursing process of lung cancer patients can effectively guide the negative emotions of patients,reduce the incidence of digestive tract reaction,the incidence of skin mucosal injury,the incidence of bone marrow suppression,improve patient compliance,and patients are more recognized for the care service.It is worthy of clinical promotion. 2020 Vol. 27 (5): 243-246 [Abstract] ( 66 ) HTML (39 KB)  PDF  (0 KB)  ( 18 ) 247 Application effect of psychological nursing combined with oral health education nursing in patients with periodontitis XU Jing-hong ；CHEN Xin-ye Objective To explore the intervention effect of psychological nursing combined with oral health education on patients with periodontitis.Methods Eighty patients with periodontitis who were treated in our hospital from February 2016 to February 2019 were enrolled as subjects in the study.They were divided into control group and observation group by random number table method,40 cases in each group.The control group received routine nursing intervention and the observation group applied psychological nursing combined with oral health education nursing.The indexes of the plaque index,periodontal pocket depth and gingival sulcus index,self-rating depression scale (SDS) and self-rating anxiety scale (SAS) were compared.Results After nursing,the plaque index,periodontal pocket depth and gingival sulcus bleeding index of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).The SDS and SAS scores of the observation group were lower than those of the control group,the differences were statistically significant (P＜0.05).Conclusion The application of psychological nursing combined with oral health education in patients with periodontitis can remarkably improve the clinical symptoms of patients,and reduce the occurrence of nervous and anxious emotions.It is worthy of promotion and application in clinic. 2020 Vol. 27 (5): 247-249 [Abstract] ( 66 ) HTML (30 KB)  PDF  (0 KB)  ( 11 ) 250 Influence of prenatal and postpartum comprehensive nursing on breast milk secretion and feeding mode of primipara ZENG Cai-xian； WANG Fu-hai ；ZENG Ke-hong； WU Xiao-yan ；LIANG Chu-ying Objective To explore the effect of prenatal and postpartum comprehensive nursing on the feeding pattern and breast milk secretion of primipara.Methods A total of 500 primipara who delivered in our hospital from January to June 2018 were selected and divided into control group and study group by random number table method,250 cases in each group.The control group received routine nursing,the study group received prenatal and postpartum comprehensive nursing.The feeding mode,lactation volume and total nursing satisfaction of the two groups were compared.Results The breast-feeding rates of the study group and control group were 96.00% and 75.60%,respectively.The breastfeeding situation of the study group was better than that of the control group (χ2=42.700,P=0.000)；the breast-milk secretion of the study group was more than that of the control group (P＜0.05)；the total satisfaction rate of nursing in the study group was 98.80%,which was higher than that in the control group (84.80%),the difference was statistically significant (P＜0.05).Conclusion Prenatal and postpartum carenursing for primipara can improve breast milk secretion and breast-feeding rate,help to promote the healthy growth of newborns,and has better clinical application value. 2020 Vol. 27 (5): 250-252 [Abstract] ( 76 ) HTML (31 KB)  PDF  (0 KB)  ( 11 )

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