急性淋巴细胞白血病患儿经CCLG～2008方案治疗后复发的相关影响因素分析

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Abstract Objective To analyze related influencing factors of relapse in children with acute lymphoblastic leukemia(ALL) children after CCLG-2008.Methods A retrospective analysis was performed on 677 newly diagnosed children who were given CCLG-2008 chemotherapy regimen during the period from January 2010 to January 2015.According to results of follow-up,they were divided into recurrence group (151 cases) and non-recurrence group (526 cases).Univariate and multivariate Logistic regression analysis were performed to analyze risk factors influencing recurrence in ALL children after CCLG-2008 treatment regimen.The main factors influencing recurrence of ALL children were analyzed.Results A total of 677 patients were treated.There were 151 cases with recurrence,with recurrence rate of 22.30%.The proportions of age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level in recurrence group were higher than those in non-recurrence group (P＜0.05).Multivariate Logistic regression analysis showed that age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level were independent risk factors influencing recurrence in ALL children(P＜0.05).Conclusion Age not less than 10 years old,newly diagnosed white blood cell count more than 100×109/L,bone marrow smear showing M3 on the 15th day,minimal residual lesions greater than 10-4 on the 12th week and high risk level are independent risk factors influencing recurrence in ALL children.

Key words： Acute lymphoblastic leukemia CCLG-2008 regimen Recurrence Influencing factor

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	Articles by authors
	XIE Shu-pei
	LIANG Chang-da
	FAN Xiao-ju

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XIE Shu-pei,LIANG Chang-da,FAN Xiao-ju. Analysis of related influencing factors of relapse in children with acute lymphoblastic leukemia after CCLG-2008[J]. 中国当代医药, 2020, 27(5): 115-117.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I5/115

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