|
|
|
| Effect of lung protective ventilation strategy on inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer |
| ZOU Bin WANG Jian-bing TANG Lang GUO Chang-ying |
| The Second Department of Thoracic Surgery,Jiangxi Cancer Hospital,Nanchang 330029,China |
|
|
|
|
Abstract Objective To study the effect of lung protective ventilation strategy on inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer.Methods A total of 75 patients with thoracoscopic radical resection of lung cancer admitted to our hospital from July 2017 to July 2018 were selected as the research objects.All patients were divided into observation group (38 cases) and control group (37 cases) according to the random number table method.The control group was treated with conventional ventilation strategy,and the observation group was treated with lung protective ventilation strategy.The inflammatory response indexes (interleukin-10 [IL-10],interleukin-8[IL-8],tumor necrosis factor-α [TNF-α]) and oxidative stress indexes (malondialdehyde [MDA],superoxide dismutase[SOD]) were compared between the two groups before and after operation.The pulmonary function of the two groups was scored with the standard pulmonary function scale.The incidence of pulmonary complications was recorded within 3 days after operation in both groups.Results The levels of IL-10,IL-8 and TNF-α after operation in the two groups were lower than those before operation,and the differences were statistically significant (P＜0.05).The levels of IL-10,IL-8 and TNF-α in the observation group after operation were lower than those in the control group,and the differences were statistically significant (P＜0.05).The levels of MDA in the two groups after operation were lower than those before operation,SOD and pulmonary function score were higher than those before operation,and the differences were statistically significant (P＜0.05).The MDA of the observation group after operation was lower than that of the control group,SOD and pulmonary function score were higher than those of the control group,and the differences were statistically significant (P＜0.05).The total incidence rate of complications in the observation group was lower than that in the control group,and the difference was statistically significant (P＜0.05).Conclusion The lung protective ventilation strategy can significantly reduce the inflammatory response and oxidative stress after thoracoscopic radical resection of lung cancer,and improve the lung function.It has high application value in clinical practice,and it is worth popularizing.
|
|
|
|
|
|
| [2] |
张娆娆，徐瑞华.呼吸窘迫综合征应用肺保护性通气策略的疗效观察[J].淮海医药，2019，37（1）：23-25.
|
| [3] |
史博文，孙冰生，岳东升，等.达芬奇手术系统与胸腔镜在肺癌根治术中的对比分析[J].肿瘤防治研究，2018，45（2）：91-95.
|
| [1] |
刘静，孟志鹏，颜伟，等.肺保护性通气策略对腹腔镜胃癌根治手术老年患者肺氧合功能及术后肺部并发症的影响[J].临床麻醉学杂志，2019，35（4）：344-347.
|
| [4] |
Costa Leme A，Hajjar LA，Volpe MS，et al.Effect of intensive vs moderate alveolar recruitment strategies added to lung-protective ventilation on postoperative pulmonary complications：a randomized clinical trial[J].JAMA，2017，317（14）：1422-1432.
|
| [5] |
朱海琴，王婧，乔建军，等.肺保护性通气策略在老年患者腹腔镜手术中的临床应用[J].医学理论与实践，2018，31（24）：3683-3684.
|
| [6] |
李建华，赵广平，赵宏娟，等.乌司他丁联合肺保护性通气策略对胸腔镜下热灌注化疗肺癌患者的影响研究[J].实用心脑肺血管病杂志，2016，24（8）：116-120.
|
| [7] |
孟杰，肖航，曾宪伟，等.超声引导下前锯肌平面阻滞对胸腔镜肺癌根治术术后镇痛及炎性反应的影响[J].临床肺科杂志，2018，23（5）：913-916.
|
| [8] |
唐玉茹，李会，帅训军，等.保护性肺通气对老年肺癌患者肺叶切除术围术期肺功能的影响[J].中国医药导报，2017，14（20）：120-124.
|
| [9] |
蒋虹，李隽，童皖宁，等.肺功能指数对肺癌胸腔镜术后患者肺部感染的影响[J].中国临床医生杂志，2018，46（5）：78-80.
|
| [10] |
李晓辉.保护性双肺复张通气对肺癌患者血清炎性反应的影响[J].实用癌症杂志，2018，33（10）：121-123，127.
|
| [11] |
陈惠英，黄德辉，刘衬云，等.容量控制通气与压力控制通气对老年肺癌肺叶切除术患者血流动力学影响的对比研究[J].中国临床医生杂志，2017，45（12）：70-72.
|
| [12] |
张丽丽，张野，李云.开胸术中保护性肺通气策略研究进展[J].安徽医学，2017，38（3）：382-384.
|
| [13] |
张学琴，张彦博，田玉红.保护性肺通气策略对开胸患者氧化应激及术后肺部并发症的影响[J].现代中西医结合杂志，2017，26（26）：2943-2945.
|
| [14] |
屈亚云，武莉芳，张秀敏，等.依达拉奉对肺癌胸腔镜手术中单肺通气相关肺损伤的保护作用[J].新乡医学院学报，2016，33（12）：1054-1056.
|
| [15] |
蔡恒宇，郜红艳.肺保护性通气策略在妇科腹腔镜手术中应用的临床观察[J].实用妇产科杂志，2017，33（7）：534-537.
|
|
|
|
