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| Effect of different vaginal administration Luteal support scheme on pregnancy outcome in patients with hormone replacement therapy and cycle frozen-thawed embryo transfer |
| ZHAI Guo-min1 GAO Yu-lin1 HUANG Jian-chu1 LAI Wen-yao1 ▲ ZHONG Wen-bin2 LI Tai-kang2 ZHOU Xiao-qin3 |
1.Reproductive Center,Dongguan Maternal and Child Health Hospital,Guangdong Province,Dongguan 523000,China；
2.Department of Obstetrics and Gynecology,Dongguan Maternal and Child Health Hospital,Guangdong Province,Dongguan 523000,China；
3.Department of Anesthesiology,Dongguan Hospital of Traditional Chinese Medicine,Guangdong Province,Dongguan 523000,China |
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Abstract Objective To observe the changes of pregnancy outcome in patients with hormone replacement therapy and frozen-thawed embryo transfer (FET) under different vaginal administration Luteal support scheme.Methods The clinical data of a total of 535 cycles of hormone replacement therapy and cycle FET in the reproductive center of Dongguan Maternal and Child Health Hospital from February 2013 to July 2018 was selected for retrospective analysis.The patients were divided into group A and group B according to different vaginal administration schemes.Group A，a total of 263 cycles,patients were treated with Progesterone Vaginal Sustained Release Gel (transvaginal) with Dydrogesterone Tablets (oral).Group B,a total of 272 cycles,patients were treated with Progesterone Soft Capsules (oral) and Dydrogesterone Tablets (oral).The clinical outcomes and adverse reactions of the two groups were compared.Results The rate of embryos implantation in the group A was higher than that in the group B (P＜0.05),and the rate of early abortion in the group A was lower than that in the group B (P＜0.05).The total incidence of adverse reactions in the group A was lower than that in the group B,the differences were statistically significant (P＜0.05).Conclusion Progesterone Vaginal Sustained Release Gel (transvaginal) with Dydrogesterone Tablets (oral) can significantly improve the rates of embryo implantation,decrease the rates of early abortion and adverse reaction.
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| Cite this article: |
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ZHAI Guo-min,GAO Yu-lin,HUANG Jian-chu, et al. Effect of different vaginal administration Luteal support scheme on pregnancy outcome in patients with hormone replacement therapy and cycle frozen-thawed embryo transfer[J]. 中国当代医药, 2020, 27(5): 112-114.
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| URL: |
| http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I5/112 |
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