强的松、硫唑嘌呤联合乙酰半胱氨酸治疗特发性间质性肺炎的效果

Abstract
Figure/Table
References (15)
Related Citation (15)

Download: PDF (0 KB) HTML (32 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the clinical effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of patients with idiopathic interstitial pneumonia.Methods A total of 62 patients with idiopathic interstitial pneumonia who were treated in our hospital from December 2012 to December 2017 were selected as the research subjects.They were divided into the control group and the observation group according to the random number table method,with 31 cases in each group.The control group was treated with Prednisone and Azathioprine,patients in the observation group were treated with Acetylcysteine on the basis of the control group.The clinical efficacy and pulmonary function indicators (vital capacity [VC],forced expiratory volume in one second occupying forced vital capacity[FEV1/FVC]and dispersion coefficient [DICO]) before and after treatment were compared in the two groups.The incidence of adverse reactions during the treatment of the two groups was recorded.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There were no significant differences in the pulmonary function indicators between the two groups before treatment (P＞0.05).The VC,FEV1/FVC and DICO after treatment in the two groups were higher than those before treatment,and the VC,FEV1/FVC and DICO in the observation group were higher than those in the control group,with statistically significant differences (P＜0.05).No significant adverse reactions occurred in the two groups of patients.Conclusion The clinical effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of patients with idiopathic interstitial pneumonia is better than that of Prednisone and Azathioprine,and it can improve the pulmonary function indicators of patients,with reliable safety.

Key words： Idiopathic interstitial pneumonia Prednisone Azathioprine Acetylcysteine Pulmonary function

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	JI Shang-ming

Cite this article:

JI Shang-ming. Effect of Prednisone,Azathioprine combined with Acetylcysteine in the treatment of idiopathic interstitial pneumonia[J]. 中国当代医药, 2020, 27(5): 37-39.

URL:

http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I5/37

[1]	王磊，张国俊.间质性肺炎的诊断与治疗进展[J].临床内科杂志，2016，33（7）：441-443.
[2]	王颖.宣肺逐瘀化痰法配合西药治疗特发性间质性肺炎39例[J].环球中医药，2017，10（1）：77-80.
[3]	陈志强，黄胜立，蔡水峰.环磷酰胺联合泼尼松治疗特发性间质性肺炎75例疗效观察[J].临床合理用药杂志，2017，25（1）：9-11.
[4]	陈健聪，吴锡平.具有自身免疫特征的间质性肺炎的特点[J].国际呼吸杂志，2018，38（4）：306-310.
[5]	闫利娟，易祥华.特发性间质性肺炎的病理诊断及临床实践中应注意的问题[J].诊断学理论与实践，2013，12（2）：135-141.
[6]	徐虹，卢慧宇.糖皮质激素、硫唑嘌呤联合乙酰半胱氨酸治疗特发性间质性肺炎的效果[J].广东医学，2016，37（16）：2492-2493.
[7]	耿君.糖皮质激素治疗特发性间质性肺炎后经高分辨率CT 半定量分值判断其近期疗效的临床分析[J].中国生化药物杂志，2017，37（9）：419-420.
[8]	喻冬芹.低分子肝素联合乙酰半胱氨酸治疗特发性间质性肺炎的疗效研究[J].中国医药指南，2017，15（26）：23-24.
[9]	刘坚.丹红加乙酰半胱氨酸治疗特发性间质性肺炎的疗效评价[J].药品评价，2016，13（24）：40-42.
[10]	赵丽琴.乙酰半胱氨酸对特发性间质性肺炎患者血气分析的影响[J].基因组学与应用生物学，2017，36（8）：3374-3378.
[11]	刘川宁，金希.低分子肝素联合乙酰半胱氨酸治疗特发性间质性肺炎的疗效[J].临床医学研究与实践，2018，3（20）：24-25.
[12]	牛莎.丹红联合乙酰半胱氨酸治疗特发性间质性肺炎的疗效评价[J].上海医药，2017，38（9）：21-23.
[13]	阳俊，胡克.低分子肝素联合乙酰半胱氨酸治疗特发性间质性肺炎的临床疗效评价[J].临床和实验医学杂志，2015，14（6）：438-442.
[14]	贺素锦.探讨低分子肝素和乙酰半胱氨酸联合治疗特发性间质性肺炎的临床效果和安全性[J].医药论坛杂志，2018，39（5）：149-151.
[15]	胡学术，龚麟，昌伦超.低分子肝素联合乙酰半胱氨酸治疗特发性间质性肺炎的疗效分析[J].中西医结合心血管病杂志，2017，5（29）：36-37.