重组人干扰素α-2b对宫颈高危HPV感染患者HPV清除率及免疫功能的影响

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Abstract Objective To investigate the effect of Recombinant Human Interferon α-2b on cervical human papillomavirus (HPV) clearance and immune function in patients with high-risk HPV infection.Methods A total of 100 patients with high-risk cervical HPV infection who were admitted to our hospital from February 2018 to March 2019 were selected and were divided into control group and study group according to random number table method,50 cases in each group.The control group received Baofukang Suppository via vagina,and the study group was added with Recombinant Human Interferon α-2b Suppository.The HPV clearance,cervical erosion-like healing,immune function and medication safety were compared between the two groups.Results The total effectiveness rate of HPV clearance in the study group was 88.00%,higher than that of the control group (60.00%),with statistical difference (P＜0.05).The total effectiveness rate of cervical erosion-like healing in the study group was 92.00%,higher than that of the control group(68.00%),with statistical difference (P＜0.05).The levels of interleukin-6 (IL-6) after treatment were higher in the two groups,and the levels of tumor necrosis factor-α (TNF-α) was lower compared with those before treatment.The level of IL-6 in the study group was higher than that in the control group,and the level of TNF-α was lower than that in the control group,with statistical differences (P＜0.05).There was no obvious adverse reaction during the treatment in two groups.Conclusion In the treatment of high-risk HPV infection of the cervix,Recombinant Human Interferon α-2b Suppository can improve the healing of HPV clearance and cervical erosion-like changes，enhance the immune function of the body，and have high safety.

Key words： High-risk cervical HPV infection；Recombinant Human Interferon &alpha -2b；HPV clearance；Immune function

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	DING Yan

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DING Yan. Effect of Recombinant Human Interferon α-2b on HPV clearance rate and immune function in patients with high-risk cervical HPV infection[J]. 中国当代医药, 2020, 27(5): 143-145.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2020/V27/I5/143

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