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2018 Vol. 25, No. 24
Published: 2018-08-28
4
Influence of nerve growth factor on transforming growth factor-β
1
and Smad protein pathway in rat hepatic stellate cell
1 and Smad protein pathway in rat hepatic stellate cell[J]. 中国当代医药, 2018,25(24): 4-7')" href="#">
ZHU Hai-yan;WU Xiong-jian;YE Yan-qing;ZENG Bin;XIE Zhi-jun
Objective
To study the influence of nerve growth factor(NGF)on the proliferation and apoptosis of hepatic stellate cell-T6(HSC-T6)and transforming growth factor-β
1
(TGF-β
1
)/Smad protein pathway change in HSC-T6 of rat,and explore the possible mechanism of NGF influencing HSC-T6 proliferation and apoptosis.
Methods
HSC-T6 of rat was cultured in vitro.HSC-T6 was incubated with different concentrations of NGF and divided into the control group(0 ng/ml NGF)and experimental group(100 ng/ml NGF).The flow cytometry was used for detection of HSC-T6 apoptosis.By XTT,the influence of NGF on the proliferation of HSC-T6 was understood.The expression of TGF-β
1
,Smad3 and Smad7 after NGF affecting on HSC was observed by immunocytochemistry.
Results
The inhibition of HSC-T6 proliferation in theexperimental group(OD valuewas0.65±0.03)wassignificantly different fromthat in the control group(OD value was 0.73±0.01)(P<0.05).The apoptosis rate of the experimental group was higher than that of the control group with a statistical difference(P<0.05).The expression of TGF-β
1
and Smad3 in the experimental group was down-regulated significantly,while the expression of Smad7 was greatly up-regulated compared with those in the control group(P<0.05).
Conclusion
NGF can inhibit the proliferation of HSC-T6 and promote its apoptosis.The mechanism may be related to the regulation of TGF-β
1
/Smad protein pathway.
2018 Vol. 25 (24): 4-7 [
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] (
331
)
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8
Study on preparation of the Resina Draconis Film-forming Spray
XU Xiao-bin;HU Hua;HUANG Hui-xue; LI Hong-fei; LU Hong-zhuang
Objective
To prepare a new formulation which can promote blood circulation to remove blood stasis and relieve swelling and pain using Resina Draconis as the main ingredient.
Methods
The single factor experiment and the orthogonal experiment were carried out to screen the ingredient and composition of a new Resina Draconis Film-forming Spray,taking the film-forming ability,homogeneity and time into account.
Results
The optimal formula for Resina Draconis Film-forming Spray was as follows:4.0%Resina Draconis powder,4.0%povidone K30 and 0.1%hydroxypropyl methyl cellulose (HPMC)for film-forming material,and 75%ethanol,appropriate amount.
Conclusion
The technique for preparing Resina Draconis Film-forming Spray is simple and stable,and the prepared products meet relevant standards.
2018 Vol. 25 (24): 8-11转16 [
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] (
263
)
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12
Influence of adding recombinant human luteinizing hormone on IVF-ET outcome in long protocol
NONG Liu-ying;TAN Xiu-qun
Objective
To investigate the influence of adding recombinant human luteinizing hormone(r-hLH)on In vitro fertilization-embryo transfer(IVF-ET)outcome in superovulation of long protocol.
Methods
A total of 538 infertile patients given long protocol of IVF-ET in Reproductive Medical Center of the Third Affiliated Hospital in Guangxi Medical University from February 2012 to December 2015 were selected.According to their serum LH level on gonadotropin(Gn)initial day,all patients were divided into the two groups:group A(n=238):LH＜0.5 mIU/ml and group B (n=300):LH>0.5 mIU/ml,and then according to different methods of adding r-hLH,they were divided into the different subgroups:group A was divided into group A1(n=72,adding rLH from the first day of Gn)and group A2(n=166,adding rLH from the eighth day of Gn.Group B was divided into group B1 (n=137,using only FSH,without r-hLH)and group B2(n=163,adding rLH from the eighth day of Gn).The basic information,main laboratory indexes and clinical outcomes were compared among four groups.
Results
Compared with group A2,the durations of Gn in group A1 was shorter,and there was a statistical difference(P<0.05).The serum E
2
level on the day of hCG,high-quality embryo rate,implantation rate and clinical pregnancy rate in group A1 were higher than those in group A2,and there were statistical differences(P<0.05).The dosage of Gn in group B2 was fewer than that in group B1,and there was a statistical difference (P<0.05).The normal fertilization rate(2PN),high-quality embryo rate and clinical pregnancy rate in B1 group were higher than those in group B2,and there were statistical differences(P<0.05).The dosage of Gn in group A2 was higher than that in group B2(P<0.05),and the E
2
level and LH level on hCG day in group A2 were lower than those in group B2,and there were statistical differences(P<0.05),and the clinical pregnancy rate in group A2 was significantly higher than that in group B2,and there was a statistical difference(P<0.05).
Conclusion
For those patients with ages younger than 35 years old and serum LH level＜0.5 mIU/ml on Gn initial day,early adding r-hLH may shorten the durations of Gn,raise the E
2
level of hCG day,increase the high-quality embryo rate,implantation rate and clinical pregnancy rate.But for patients with LH≥0.5 mIU/ml,adding r-hLH is not beneficial to the clinical outcomes.
2018 Vol. 25 (24): 12-16 [
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204
)
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17
Application effect of Dexmedetomidine via patient-controlled sedation in ophthalmologic strabismus surgery
GAO Xin-ming;CAO He;DENG Fen-fen;Karthikeyan Arcot Sadagopan;Dennis Lam;WEI Yang
Objective
To investigate the efficacy and safety of Dexmedetomidine for patient-controlled sedation(PCS)in ophthalmologic strabismus surgery.
Methods
A total of 40 patients with ophthalmologic strabismus who were performed with surgeries in our hospital from October 2016 to October 2017 were selected.They were aged from 16 to 35 years old,with ASAⅠorⅡ,and were randomly assigned to control group(Cgroup)and patient-controlled sedation group(PCS group),with 20 cases in each group.In the control group,normal saline at a constant velocity of 1.0 ml/h was pumped.In the PCSgroup,0.2μg/kg Dexmedetomidine before local anesthesia was intravenously pumped within 10 min.After that,0.1 μg/(kg·h)Dexmedetomidine as a maintenance dose was provided in a single dose of 1.0 ml once (4 μg/ml)at 60 s.The indexes of heart rate(HR),mean arterial pressure(MAP),oxyhemoglobin saturation(SpO
2
),and Ramsay sedation score before pump loading(T
0
),end of loading(T
1
),surgery beginning(T
2
),5 min during surgery(T
3
),10 min during surgery(T
4
),20 min during surgery(T
5
),30 min during surgery(T
6
),termination of surgery(T
7
),degree of cooperation,satisfaction,and the incidence of adverse reactions were compared between two groups.The number of compressions in the PCSgroup was recorded.
Results
The MAP of T
2
-T
7
in the PCSgroup were lower than that of T
0
,which was lower than that in the C group,with statistically significant difference(P<0.05).The HR of T
1
-T
7
in the PCSgroup were significantly lower than that of T
0
,which were lower than that in the C group,and the differences were statistically significant(P<0.05).There was no significant difference between MAP,HR of T
1
-T
7
and T
0
in the C group (P>0.05).There was no significant difference in Ramsay sedation scores of T
0
,T
1
and T
7
in the two groups(P>0.05).The Ramsay sedation scores of T
2
-T
7
in the PCSgroup were higher than those of T
0
,and the differences were statistically significant(P<0.05).There were no significant differences in Ramsay sedation scores of T
1
-T
7
and T
0
in two groups (P>0.05).The Ramsay sedation score of T
7
in the C group was higher than that of T
0
,and the difference was statistically significant(P<0.05).The Ramsay sedation scores of T
2
-T
6
in the PCSgroup were higher than those in the C group,and the differences were statistically significant(P<0.05).The satisfaction and cooperation of patients in the PCSgroup were better than those in the C group,and the differences were statistically significant(P<0.05).The incidence of discomfort,agitation,and moan in the PCSgroup was significantly lower than that in the C group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of oculocardiac reflex between two groups(P>0.05).After the patients in the PCS group were given a load,the number of effective compressions was (10.7±5.9).
Conclusion
Dexmedetomidine in PCScan be safely and effectively used in ophthalmologic strabismus surgery.It can fully reflect the individualized medication and the patients′satisfaction is significantly higher.
2018 Vol. 25 (24): 17-21 [
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] (
225
)
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22
Application effect comparison of non-precious metal and precious metal porcelain crowns in the elderly oral repair
FENG Jian-guo;LI Hui;LIU Yan-yan
Objective
To explore the application efect of non-precious metal and precious metal porcelain crowns in the elderly oral repair.
Methods
The clinical data of 184 elderly patients given with oral repair admitted into our hospital from January 2013 to December 2014 were retrospectively analyzed.All patients were divided into the non-precious metal group(n=119 cases)and precious metal group （n=65 cases）according to the different ceramic crown material.The non-precious metal group was given repair of nicochrome,while the precious metal group was given repair of platino.Satisfaction degree at the end-of-follow-up of porcelain-fused-to-metal crowns and improved plaque index grading at 3 and 6 months after porcelain-fused-to-metal crowns were compared between the two groups.
Results
The satisfaction degree of porcelain crown color(95.4%),marginal compatibility(96.9%),neck margin staining(98.5%),gingival condition(92.3%),and repair body type(98.5%)in patients of the precious metal group was significantly higher than that of the non-precious metal group(84.9%,85.6%,79.8%,80.7%,78.2%)respectively,and the differences were statistically significant(P<0.05).The grading of the improved plaque index in the precious metal group(grade A:18 cases,grade B:23 cases,grade C:10 cases,grade D:14 cases)after implantation for 3 months was significantly better than that in the non precious metal group(grade A:21 cases,grade B:28 cases,grade C:38 cases,grade D:32 cases),and the grading of the improved plaque index in the precious metal group(grade A:18 cases,grade B:21 cases,grade C:7 cases,grade D:19 cases)after implantation for 6 months was significantly better than that in the non precious metal group(grade A:15 cases,grade B:19 cases,grade C:38 cases,grade D:47 cases)and the differences were statistically significant(P<0.05).
Conclusion
In the elderly dental implant restoration,the precious metal porcelain crown has a significant advantage compared with non precious metal porcelain crown in biocompatibility and aesthetics,and it is beneficial to the periodontal health of the implant.after planting and repairing.
2018 Vol. 25 (24): 22-25 [
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] (
194
)
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26
Analysis of Patents involved in autism treatment drugs in China
DENG Li-juan; ZHANGZheng;YANGQian;LAI Fang-fang
Autism refers to the widespread developmental disability that occurs in children from birth to early childhood.There is currently no clinically specific drug for the treatment of the disease.Symptomatic treatment with drugs such as antipsychotics,antidepressants and sleep disorders is often used.Therefore,autism treatment drugs have huge clinical needs and broad market prospects.This article describes the status of domestic invention patents of autism treatment drugs.The number of applications,technical fields,and types of applicants is analyzed from multiple perspectives.It also analyzes the patent layout of the representative applicant Roche Pharmaceutical Co.,Ltd.The hot spots and trends of drug development is analyzed and summed up,which might provide reference for the related research in the pharmaceutical industry in China.
2018 Vol. 25 (24): 26-29 [
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] (
256
)
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30
Application status and research progress of ultrasound-guided nerve block
LAN Ying-nian;WEI Hui;HUANG Xiao;ZHOU Fei-ren;TAN Xin-mei
Ultrasound-guided nerve block is widely recognized due to reducing the blindness of operations and increasing the success rate at present.Ultrasound-guided nerve block can be used to the different parts of the body,such as cervical shoulder,brachial plexus,thoracic vertebrae,lumbar plexus and sacral,and so on,whose nerve and associated blood vessels can be shown by ultrasound-guided nerve block,which provides the prerequisites for ultrasoundguided nerve block.Ultrasound-guided nerve block can not obviously decrease the incidence of nerve injury caused by puncture,but ultrasound-guided nerve block combined with nerve stimulator may improve the safety of nerve block operation.The article reviews the clinical application of ultrasound-guided nerve block.
2018 Vol. 25 (24): 30-32转36 [
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] (
225
)
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33
Research progress on the role of Tai Chi exercise in adjuvant therapy of diabetes
LI Rong; ZHANGBin;REN Tian-shun; XU Gang-zhu;ZHAOHang
Diabetes mellitus is one of the important chronic non-communicable diseases.The prevalence and number of patients increase year by year.As the disease progresses,diabetes can affect all organs and tissues of the body.Its treatment measures include exercise,diet,education,monitoring and medication.Tai Chi,as a kind of exercise therapy,is one of the main measures in the management of diabetes healthy exercise and can be used as intervention or adjuvant treatment.This paper reviews the recent progress in the role of Tai Chi exercise in diabetes therapy.
2018 Vol. 25 (24): 33-36 [
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] (
190
)
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37
Research progress on risk factors and protective measures of venous thrombosis after PICC catheter placement in elderly patients undergoing chemotherapy for cancer
ZHANG Xiao-man;SONGJie;WANG Yan-yan;WANG Ye-qing;MENG Huan
Peripherally inserted central venous catheterization(PICC)is a common route for intravenous administration of tumor patients.However,PICC is an virulence and invasive operation.It will bring different degrees of discomfort to patients,especially for elderly patients with chemotherapy,which is likely to cause PICC related complications.PICC related venous thrombosis is one of the more serious complications.The formation of venous thrombosis is mainly associated with tumor catheter type,position of pipe,patient factors and nursing related factors.This article reviewed the risk factors and protective measures of venous thrombosis after PICC catheter placement in elderly patients undergoing chemotherapy.It can provide reference for effective prevention and reduction of thrombosis in clinic.
2018 Vol. 25 (24): 37-39 [
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] (
200
)
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40
Research progress of sphingomyelin
SHU Wen-zhang; LIU Shuang-xi;ZHOU Wei-hua;HUANGHai-yan;CHEN Yan
At present,there are many research on proteins at home and abroad,but little on lipids.Sphingomyelin is a lipid with a major proportion on the cell membrane.It participates in cell proliferation and differentiation,regulates inflammation,and changes membrane fluidity and structure.Sphingomyelin is related to the occurrence and development of many diseases.Overseas research on sphingomyelin has been confirmed by most literature in some aspects,but there are still many controversies in other aspects.Few reports on sphingomyelin in China,and this paper plans to review the research of sphingomyelin.
2018 Vol. 25 (24): 40-43 [
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285
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44
Treatment effect of high intensity focused ultrasound on ovarian cancer and its influence on immune function of rats
XIONG Hui; LIU Xiao-hong;ZHOU Xin;YANG Zhi-li;XIAO Ju-hua
Objective
To investigate the treatment effect of high intensity focused ultrasound on ovarian cancer and its influence on immune function of rats.
Methods
A total of 40 SD rats were selected to construct ovarian cancer in situ models and were randomly divided into control group and HIFU group.HIFU group was treated with local HIFU,while the control group was treated with sham irradiation.The survival state of rats in the two groups were observed,the growth of the tumor were detected,the histomorphological changes of the tumor were observed by HE staining,and the level of CD4
+
and CD8
+
in the plasma were detected by flow cytometry.
Results
In HIFU group,the living conditions of the rats were not changed or improved treated by HIFU for 7 days,while the rats in the control group gradually failed.The median survival time of rats in HIFU group was(48.0±4.5)d,which was significantly longer than that in the control group ([40.0±3.6]d)(P<0.05).The average weight of tumor in HIFU group was(1.37±0.92)g,which was significantly lower than that in control group([2.86±0.73]g)(P<0.05).There were significant morphological changes in the ovarian tissue of rats in HIFU group,and the CD4
+
in the plasma was significantly higher than that in the control group,while the CD8
+
was significantly lower than the control group,and the CD4
+
/CD8
+
was higher than the control group,and the differences were statistically significant(P<0.05).
Conclusion
HIFU may inhibit tumor growth,which may be related to enhancing immune function of the body.
2018 Vol. 25 (24): 44-46 [
Abstract
] (
198
)
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47
Experimental study of Buzhongyiqi Decoction combined with anti-fungal agents treating invasive candidiasis
LIN Tong; ZHANG Yu-qi; LI Xiao-yue
Objective
To investigate the effectiveness and possible mechanism of Buzhongyiqi Decoction combined with anti-fungal agents treating invasive candidiasis.
Methods
Sixty male Kunming mice were pretreated with CTX and then injected with Candida albicans suspension in abdominal cavity,the IC mice model was made.After modeled successfully,they were randomly divided into control group(n=30)and experimental group(n=30).Two groups were given antifungal therapy,while mice in the experimental group were given Buzhongyiqi Decoction of 4 g/（kg·d）and the control group was given the same amount of normal saline.The survival rate in the seventh day in the two groups were observed.The expressions of TNF-α,IL-6 and IL-10 in liver tissues and serum of IC mice were detected by ELISA.The expressions of CD3
+
,CD4
+
,CD8
+
and CD4
+
/CD8
+
in lymphocyte subsets of IC mice were detected by flow cytometry.
Results
The survival rate in the seventh day of the experimental group was significantly higher than that of the control group (P<0.05).The expressions of IL-10 in liver tissue and serum of IC mice in the experimental group were significantly lower than those of the control group (P<0.05).There were no significant difference in liver tissue and serum on expressions of TNF-αand IL-6 in IC mice between the two groups (P>0.05).The ratio of CD4
+
/CD8
+
in lymphocyte subsets of IC mice in the experimental group were significantly higher than that of the control group (P<0.05).There were no significant difference of CD3
+
,CD4
+
and CD8
+
expressions in lymphocyte subsets of IC mice between the two groups(P>0.05).
Conclusion
Buzhongyiqi Decoction combined with anti-fungal agents can improve the survival rate in the seventh day of IC mice,which may be related to the enhancement of cellular immune function and the reduction of immunosuppression.
2018 Vol. 25 (24): 47-49转62 [
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] (
219
)
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50
Effect analysis of laparoscopic total extraperitoneal inguinal hernia repair in the treatment of recurrent inguinal hernia
QIU Guo-huang;DENG Guo-jun;LIU Zhi-wei;WU Gui-jian;LI Ming-yong
Objective
To investigate the clinical effect of laparoscopic total extraperitoneal inguinal hernia repair in the treatment of recurrent inguinal hernia.
Methods
Forty-one patients with recurrent inguinal hernia admitted to our hospital from September 2015 to March 2017 were selected as the research objects.they were randomly divided into control group(n=20)and experimental group(n=21)by odd-even number.Patients in the control group were treated with conventional patch tension-free hernioplasty while patients in the experimental group were treated with laparoscopic total extraperitoneal inguinal hernia repair.the clinical therapeutic effects of the two groups of patients with recurrent inguinal hernia after treatment were compared.
Results
The utilization rate of analgesic drugs and the incidence of postoperative complications in the experimental group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).The operation time,postoperative bed time and postoperative pain time in the experimental group were shorter than those in the control group,and the bleeding amount in the experimental group was significantly less than that in the control group,the differences were statistically significant(P<0.05).
Conclusion
The effect of laparoscopic total extraperitoneal inguinal hernia repair is good for patients with recurrent inguinal hernia.The patients have less surgical trauma,reduce postoperative complications,and the patients get out of bed early after surgery,which is conducive to postoperative recovery and prognosis.
2018 Vol. 25 (24): 50-52 [
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] (
229
)
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53
Study on the relationship between type 2 diabetes mellitus and osteoporosis
ZHU Zhi-cheng;DU Ling-chao;GUOCai-xia
Objective
To study the relationship between type 2 diabetes(T2DM)mellitus and osteoporosis.
Methods
From September 2015 to February 2017,96 patients with T2DM mellitus who were treated in our hospital were divided into two groups:blood glucose control group(n=48)and blood glucose control substandard group(n=48).In addition,48 healthy patients in the same period were selected as the control group.At the same time,96 patients with diabetes mellitus were divided into osteoporosis group(n=37),normal group(n=13),and bone mineral density decrease(n=46)according to the degree of osteoporosis three groups were divided into three groups：25(OH)D
3
（25 hydroxyvitamin D
3
）,blood calcium,Urine calcium,serum magnesium and PTH (parathyroid hormone),course of diabetes and HbA1c(glycosylated hemoglobin)were compared.
Results
①25(OH)D
3
in blood glucose control group was lower than that in control group,serum magnesium was lower than that in control group and the urinary calcium index was higher than that in control group.The differences were statistically significant(P＜0.05）,25(OH)D
3
,ALP,serum magnesium in blood glucose control substandard group were lower than those in the control group,and the urinary calcium index was higher than that in the control group.The differences were statistically significant(P＜0.05）.②PTH,course of diabetes and HbA1c in osteoporosis group were significantly higher than those in control group and BMD decrease,the differences were statistically significant(P＜0.05）.③The independent risk factors for the decrease of bone mineral density in diabetes mellitus were significan PTH,the course of diabetes and HbA1c and 25(OH)D
3
.
Conclusion
There was a significant correlation between T2DM and osteoporosis.The course of diabetes and the effect of HbA1c and 25(OH)D
3
on the bone mineral density of type 2 diabetes mellitus.
2018 Vol. 25 (24): 53-55 [
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186
)
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56
Investigation and analysis of the incidence of metabolic syndrome and its related risk factors in outpatients with schizophrenia
Xie Ji-qun;YU Wei-lu; OUYANG Shao-wei; ZHONG Yuan-hui; ZHANG Zhi-bin
Objective
Toexplore the incidence and risk factorsof metabolic syndrome(MS)in outpatients with schizophrenia.
Methods
There were212 casesof schizophrenia diagnosed in the Third People′s Hospital of Meizhou City from March to October 2017 were selected,and 212 patients with schizophrenia were diagnosed according to ICD-10.
Results
There were 197 patients were collected,the response rate was 92.3%,and 25.4%(50/197)patients had MS.Under the condition of entering levelα=0.05 and excluding levelβ=0.10,two classification Logistic regression analysis was carried out.MS was set as dependent variable,demographic basic data and clinical data were set as independent variables.The results of Logistic regression showed that the higher level the FBG and SBP get,the higher prevalence MS had,while the higher the education level and HDL-C,the lower the prevalence of MS.
Conclusion
About 1/4 of outpa tients with schizophrenia have MS.In addition,high FBG,high SBP,low educational background and low(HDL-C)may be the causes of MSin outpatients with schizophrenia.Furthermore,MSis the risk fator for,cardiovascular disease.
2018 Vol. 25 (24): 56-58 [
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] (
208
)
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59
Influence of enabling education model on self-management of hypertension patients in community
LIN Shi-ta; ZHU Wei-hua;HU Ze-jiao;YANG Jian-ying
Objective
To analyze the impact of the empowerment education model on self-management of patients with hypertension in the community.
Methods
A total of 234 patients with primary hypertension in Sha two blue sky community health service center,Bao′an District in Shenzhen City,from December 2014 to November 2017 were selected as the subjects.According to the order of treatment,they were divided into 2 groups,117 cases in each group.The control group was received routine health education,while the observation group was implemented the empowerment education mode.The self-efficacy score of the two groups was analyzed.Blood pressure in the two groups before and after intervention was analyzed.
Results
There was no significant difference between the two groups of symptoms management self-efficacy,common management self-efficacy and total self-efficacy score before intervention (P＞0.05）.After the intervention,the symptoms management self-efficacy,the common management self-efficacy and the total self-efficacy score of the two groups were all higher than those before the intervention,and the difference was statistically significant(P＜0.05）.The symptom management self-efficacy,the common management self-efficacy of the disease and the total self-efficacy score of the observation group were higher than those of the control group,the difference was statistically significant(P＜0.05）.There was no significant difference in SBPand DBPbetween the two groups before intervention(P＞0.05）.After intervention,the SBP and DBPof the two groups were significantly lower than those before the intervention,and the difference was statistically significant(P＜0.05）.The SBPand DBPof the patients in the observation group were lower than those in the control group,and the difference was statistically significant(P＜0.05）.
Conclusion
For the community hypertension patients,the implementation of the educational model can improve the self-efficacy of the patients,improve their blood pressure control and reduce the incidence of cardiovascular and cerebrovascular diseases.It is worth to use in clinical practice.
2018 Vol. 25 (24): 59-62 [
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] (
203
)
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63
Comparison of the effects of mechanical ProTaper nickel-titanium file and stainless steel K file in the treatment of molar root canal
YE Hua-hai;XU Wei-qiang
Objective
To investigate the clinical effect of the machine-made ProTaper nickel-titanium file and stainless steel k file in the root canal treatment of molars.
Methods
A total of 112 patients with 120 teeth were selected from January to December 2017 for root canal treatment of molars in our hospital.The patients were randomly divided into nickel-titanium file group(56 cases,61 teeth)and stainless steel group(56 cases,59 teeth)according to the order of their visit.They were treated with ProTaper nickel-titanium file and stainless steel k file respectively.The root canal treatment effects of the two groups were compared.
Results
The root canal preparation time and filling time of nickeltitanium file group were significantly lower than those of stainless steel group,and the good rate of root canal preparation shape of nickel-titanium file group was significantly higher than that of stainless steel group,the differences were statistically significant(P<0.05).The separation rate of the nickel-titanium file group was lower than that of the stainless steel group,and the filling rate of the nickel-titanium file group was obviously higher than that of the stainless steel group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the pain rate between the two groups at 1,3 h after root canal surgery(P>0.05).The pain rates at 24,72 h after operation in the nickel-titanium file group were significantly lower than those in the stainless steel group,the differences were statistically significant(P<0.05).
Conclusion
The machine-made ProTaper nickel-titanium file has good clinical effect in molar root canal treatment,shortens root canal preparation and filling time,can improve the good rate and just filling rate of root canal preparation shape,reduces the incidence of postoperative pain,is safe and reliable,and is worthy of clinical recommendation.
2018 Vol. 25 (24): 63-65 [
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] (
258
)
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66
Comparison of laparoscopic surgery and traditional open surgery in the treatment of acute appendicitis
ZHAO Yu-feng
Objective
To investigate the clinical effect of laparoscopic surgery and traditional open surgery in the treatment of acute appendicitis.
Methods
A total of 120 patients with acute appendicitis in our hospital from January to December 2017 were selected and divided into control group and observation group according to surgical methods,with 60 cases in each group.The control group was treated with traditional open surgery while the observation group was treated with laparoscopic surgery.The clinical treatment effects of the two groups were compared.
Results
The operation time of the patients in the observation group was obviously shorter than that of the control group.The amount of bleeding in the observation group was less than that of the control group,and the incision was less than that of the control group,the differences were statistically significant(P<0.05).The recovery time of gastrointestinal function,ambulation time and hospitalization time in the observation group were significantly shorter than those in the control group,the differences were statistically significant(P<0.05).The total incidence of complications in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).
Conclusion
Compared with traditional laparotomy,laparoscopic surgery can obviously shorten the treatment time,reduce the incidence of complications,promote recovery,and has high clinical application value.
2018 Vol. 25 (24): 66-68 [
Abstract
] (
192
)
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69
Effect of
131
I on Graves′disease and its influence on A-TPO and TRAb levels
131I on Graves′disease and its influence on A-TPO and TRAb levels[J]. 中国当代医药, 2018,25(24): 69-71')" href="#">
LAN Hao;LIWen-bin;CHEN Qin
Objective
To investigate the effect of 131 I treatment on patients with diffuse toxic goiter(Graves′disease)and its influence on the levels of antithyroid peroxidase antibody (A-TPO)and thyrotropin receptor antibody(TRAb).
Methods
From July 2015 to January 2017,100 patients with Graves′disease were selected and divided into control group and experimental group with 50 patients in each group by random number table method.The control group was treated with ATD while the experimental group was treated with
131
I.The TSH,A-TPO,TRAb levels,thyroid quality,clinical efficacy and total incidence of adverse reactions were compared between the two groups.
Results
After treatment,the TSH levels of the two groups were higher than those before treatment,and the levels of A-TPO and TRAb were lower than those before treatment.the differences were statistically significant(P<0.05).The levels of A-TPO and TRAb in the experimental group were lower than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in thyroid quality between the two groups before and after treatment(P>0.05).The total effective rate of the experimental group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the experimental group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).
Conclusion
Graves′disease patients receiving
131
I treatment has good clinical effect,and can effectively improve the patient′s A-TPO,TRAb levels,and is safe and effective,worthy of clinical promotion.
2018 Vol. 25 (24): 69-71 [
Abstract
] (
164
)
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72
Effect of ambroxol bronchoalveolar lavage on bronchiectasis and infection
XIAOYu-Ran;ZHANGXin-yi
Objective
To investigate the effect of ambroxol bronchoalveolar lavage on bronchiectasis and infection.
Methods
From July 2016 to November 2017,114 patients with bronchiectasis and infection admitted to the Second Affiliated Hospital of Nanchang University were selected and divided into control group and study group with 57 cases in each group by random number table method.The control group was treated with bronchoalveolar lavage with normal saline,while the study group was treated with ambroxol lavage,and the therapeutic effects of the two groups were analyzed.
Results
After treatment,the related lung function indexes of the patients in the study group were higher than those of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the study group was significantly higher than that of the control group，and the difference was statistically significant(P<0.05).
Conclusion
In clinic,ambroxol bronchoalveolar lavage is used to treat patients with bronchiectasis infection and effectively control their infection symptoms,which is worth popularizing.
2018 Vol. 25 (24): 72-74 [
Abstract
] (
226
)
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31
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75
Application effect of nasal high flow humidified oxygen therapy in acute respiratory failure
XU Ying-hui; LI Xiang;LI Zhe-yong;XU Dan;MA Jia
Objective
To investigate the effect of nasal high flow humidified oxygen therapy in acute respiratory failure.
Methods
A tolal of 88 patients with acute respiratory failure admitted to our hospital from December 2015 to December 2017 were selected and divided into control group and observation group with 44 cases in each group by random number table method.Patients in the control group were given conventional oxygen therapy while patients in the observation group were given nasal high flow humidified oxygen therapy.The blood gas index,treatment time and incidence of adverse events were compared between the two groups.
Results
After treatment,the respiratory rate,PaCO
2
and heart rate indexes of the two groups were lower than those before treatment,and PaO
2
,and SpO
2
indexes were higher than those before treatment,the differences were statistically significant(P<0.05).The respiratory rate,PaCO
2
,and heart rate indexes of the observation group were lower than those of the control group after treatment,and the PaO
2
,and SpO
2
indexes were higher than those of the control group,the differences were statistically significant(P<0.05).The ICU stay time and hospitalization time of patients in the observation group were shorter than those in the control group,and the utilization rate of mechanical ventilation of patients in the observation group was lower than that in the control group,the differences were statistically significant(P<0.05).The incidence of adverse events in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).
Conclusion
Transnasal high flow humidified oxygen therapy can improve the blood gas index of patients with acute respiratory failure,shorten the treatment time and improve the safety.
2018 Vol. 25 (24): 75-77 [
Abstract
] (
202
)
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32
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78
Application value of laparoscopic cholecystectomy in the treatment of cholelithiasis
LUO Wen-bin;HUANG Hui
Objective
To investigate the clinical value of laparoscopic cholecystectomy in the treatment of cholelithiasis.
Methods
A total of 200 cholelithiasis patients admitted to Gao′an Hospital of Troditional Chinese Medicine in Jiagnxi Province from January 2015 to December 2017 were selected for laparoscopic cholecystectomy,and the therapeutic effect of the patients was analyzed.
Results
After treatment,102 cases(51.00%)were markedly effective,84 cases(42.00%)were effective,14 cases(7.00%)were ineffective,and the total clinical effective rate was 93.00%.The operation time was(69.52±11.35)min,the amount of bleeding during the operation was(43.56±9.36)ml,the first time of exhausting gas after the operation was(13.36±3.25)h,the first time of getting out of bed after the operation was(12.66±4.58)h,and the hospital stay was(5.02±1.36)d.There were 12 cases of abdominal infection(6.00%),8 cases of incision infection(4.00%),6 cases of respiratory infection(3.00%),2 cases of renal insufficiency(1.00%),and the total incidence of complications was 14.00%.After treatment,the quality of life scores of gallstone patients were significantly higher than those before treatment,the differences were statistically significant(P<0.05).
Conclusion
The application of laparoscopic cholecystectomy in the treatment of gallstones can achieve good results,the incidence of complications is relatively low,and can effectively improve the quality of life of patients.It has significant clinical value and is worth promoting.
2018 Vol. 25 (24): 78-80 [
Abstract
] (
216
)
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81
Effect of comprehensive aerobic exercise intervention on fatty liver in simple obesity children
BAI Da-ming;ZOU Yu;ZHANGPeng;DAI Dong-ling;ZHOU Shao-ming
Objective
To investigate the effect of comprehensive aerobic exercise intervention on fatty liver in simple obese children.
Methods
A total of 60 children with simple fatty liver admitted to our hospital from May 2015 to March 2017 were selected and divided into observation group and control group by random number table method,with 30 cases in each group.The children in the control group did not take any intervention measures.The children in the observation group received comprehensive aerobic exercise intervention.After one year,the liver function related indicators and weight related indicators of the two groups of children were analyzed and compared.
Results
After the intervention,the height of the two groups of children was significantly higher than that before the intervention,the difference was statistically significant(P<0.05).There was no statistically significant difference in height between the two groups after intervention(P>0.05).The weight and BMI of the two groups after intervention were significantly lower than those before intervention,and the differences were statistically significant(P<0.05).The weight and BMI of the observation group were significantly lower than those of the control group after the intervention,and the differences were statistically significant(P<0.05).The related indexes of liver function in the observation group were significantly lower than those before the intervention,and the differences were statistically significant(P<0.05).The related indexes of liver function in the observation group were significantly lower than those in the control group after intervention,and the differences were statistically significant(P<0.05).
Conclusion
The comprehensive intervention of aerobic exercise for children with simple obesity and fatty liver can obviously improve the clinical indicators,effectively control the weight and enhance the health awareness of the children.
2018 Vol. 25 (24): 81-83 [
Abstract
] (
218
)
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84
Effect of open fistula resection on anal fistula
WANGZhi-liang;ZHOU Jing-yi
Objective
To investigate the effect of open fistula excision on anal fistula.
Methods
A total of 120 patients with anal fistula admitted to our hospital from October 2014 to October 2016 were selected as research objects,and divided into control group and observation group by sampling method,with 60 cases in each group.The control group was treated with traditional fistula excision while the observation group was treated with open fistula excision.The hospital stay,wound healing time,clinical treatment effect,postoperative infection and recurrence were evaluated and compared between the two groups.
Results
The hospital stay and wound healing time in the observation group were significantly shorter than those in the control group,the differences were statistically significant(P<0.05).The cure rate of the patients in the observation group was significantly higher than that of the control group after treatment,and the infection rate and recurrence rate of the patients in the observation group were significantly lower than that of the control group,the differences were statistically significant(P<0.05).
Conclusion
The clinical application of open fistula resection in the surgical treatment of anal fistula is conducive to shortening the hospitalization time and wound healing time,promoting postoperative recovery,improving the cure rate,reducing the postoperative infection rate and reducing the postoperative recurrence rate.It has high clinical application value and is worthy of further promotion in anorectal department.
2018 Vol. 25 (24): 84-86 [
Abstract
] (
209
)
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5
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87
Clinical effect of Thiotropium Bromide assisted bronchoalveolar lavage in the treatment of bronchiectasis with pulmonary infection
QIN Hong;ZHANG Hong-bo
Objective
To investigate the clinical effect of Thiotropium Bromide assisted bronchoalveolar lavage(BAL)in the treatment of bronchiectasis with pulmonary infection.
Methods
A total of 52 cases of bronchiectasis with pulmonary infection patients in our hospital from January 2016 to August 2017 were selected as the objects,all the patients were divided into the control group and the observation group according to the difference treatment methods,26 cases in each group.The control group was treated with BAL,the observation group was treated with Tiotropium Bromide assisted BAL treatment.The lung function,blood gas index and BODE index score and quality of life index(QLI)score were observed between the two groups.
Results
After treatment,the level of FVC,FEV
1
,FEV
1
%in the observation group were higher than those of the control group(P＜0.05）.The level of PaCO
2
in the observation group after treatment was lower than that in the control group,the level of PaO
2
/FiO
2
in the observation group after treatment were higher than those in the the control group(P＜0.05）.The BODE index score after treatment of the observation group was obviously lower than that of the control group,the QLI scores after treatment of the observation group was significantly higher than that of the control group,the differences were statistically significant(P＜0.05）.
Conclusion
Thiamethoxam bromide auxiliary BAL in the treatment of patients with pulmonary infection can effectively improve the pulmonary function,blood gas,improve the quality of life,with high clinical value.
2018 Vol. 25 (24): 87-89 [
Abstract
] (
201
)
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29
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90
Clinical effect of Dexmedetomidin′s Nasal Drip for inguinal hernia surgery in children′s sedation and postoperative restlessness
SHI Lei;ZHANG Jia-qun;FENGYing-ni
Objective
To explore the clinical effect of the sedation and the prevention of restlessness in children with inguinal hernia before the operation of Dexmedetomidin for inguinal hernia surgery.
Methods
Selected 60 children undergoing inguinal hernia surgery in our hospital from January 2016 to December 2017 were divided into contron group and study group according to the random number table method,30 cases in each group.The control group were dripped into saline by nose,the study group were dripped into Dexmedetomidine through the nose before operation.The sedation score,separation emotion score,mask resistance score,laryngeal mask extraction time,recovery time,postoperative 30 min,1 h and postop 2 h,restlessnessscore of twogroupsof patients were compared between the two groups after 30 min treatment.
Results
The sedative score of 30 min in the study group was significantly lower than that of the control group,and the difference was statistically significant(P＜0.05）.The separation emotion score of 30 min in the study group was significantly higher than that of the control group(P＜0.05）.The masks resistance score of 30 min in the study group was significantly better than that of the control group,and the difference was statistically significant(P＜0.05）.There was no significant difference between the two groups of laryngeal mask extraction time and waking time(P＞0.05）.The restlessness scores of 30 min,1 h after operation and 2 h after operation in the study group were significantly lower than those in the control group (P<0.05）.
Conclusion
Preoperative Dexmedetomidine Drip through the nose has good sedative effect in children with inguinal hernia surgery.It does not affect the quality of awakening and reduce the incidence of postoperative agitation.It is worthy of clinical promotion.
2018 Vol. 25 (24): 90-92 [
Abstract
] (
174
)
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93
Effects of permissive hypercapnia on Propofol combined with Sufentanil combined intravenous anesthesia
LI Qiu-yan
Objective
To investigate the effect of permissive hypercapnia on Propofol combined with Sufentanil combined intravenous anesthesia.
Methods
From March 2016 to March 2017,90 cases of general anesthesia were selected in our hospital as study objects,and the patients were randomly divided into the control group(45 cases)and the study group (45 cases)according to the order of admission time.During the period of anesthesia,the arterial carbon dioxide partial pressure(PaCO
2
)of the control group was between 35～40 mmHg,while the study group was PaCO
2
between 50～65 mmHg.The application of Propofol in two groups was compared(the concentration of Propofol and abdominal exploration and the time of postoperative recovery)and the PaCO
2
level of 1,2 h after operation.
Results
①In the study group,the concentration of the effector domain was (2.511±0.206)mg/L at skin incision,and the concentration of the effector domain was(2.146±0.282)mg/L at intraperitoneal exploration,were lower than those of the study group(3.223±0.188)mg/L and(2.883±0.211)mg/L respectively,and the difference was statistically significant(P＜0.05）.The recovery time in control group was(15.35±3.22)min,which was not significantly different from that in the study group(16.68+5.36)min(P＞0.05）.②The PaCO
2
levels of 1,2 h in the study group were(57.45±5.33)mmHg and(59.39±5.66)mmHg respectively,which were significantly higher than those in the control group(35.24±4.32)mmHg and(37.56±5.68)mmHg,and the difference was statistically significant(P＜0.05）.
Conclusion
It is safe and feasible to adopt permissive hypercapnia in patients undergoing general anesthesia.
2018 Vol. 25 (24): 93-95 [
Abstract
] (
153
)
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96
The effect of recovery quality with Dezocine combined with Ketorolac Tromethamine after laparoscopic cholecystectomy preoperative analgesia
CHEN Yue-sheng
Objective
To investigate the effect of recovery quality with Dezocine combined with Ketorolac Tromethamine after laparoscopic cholecystectomy preoperative analgesia.
Methods
A total of 106 cases of laparoscopic cholecystectomy in our hospital from August 2016 to August 2017 were selected as the subjects.The randomized digital table was used to divide them into control group and study group,53 cases in each group.The control group was given Ketorolac Tromethamine before operation,and the study group was given Dezocine combined with Ketorolac Tromethamine.The operative condition(operative time,propofol dosage and recovery time),pain visual analogue scale(VAS)score and sedation Ramsay score were compared between the two groups.
Results
①The dosage of Propofol in the study group was significantly lesser than that of the control group,the difference was statistically significant(P＜0.05）.There was no significant difference between the two groups of operation time and the awakening time(P＞0.05）;②The VASscore of 8,12 h pain in the control group was significantly lower than that of 1 h after operation,and the Ramsay score of 8 h sedation after operation was significantly higher than that of preoperative 1 h,the difference was statistically significant(P＜0.05）,and the VASscore and the sedative Ramsay score in the study group were significantly lower than that of the postoperative 1 h,and the difference was statistically significant(P＜0.05).The VASscore of 12 h pain was significantly lower than that of the control group,the sedation Ramsay scores of 1 and 4 h after operation were significantly higher than those of the control group,and the difference was statistically significant(P＜0.05）.
Conclusion
In laparoscopic cholecystectomy,the analgesic effect of Dezocine combined with Ketorolac Tromethamine is better,and it can effectively reduce the occurrence of postoperative restlessness and improve the quality of postoperative recovery.
2018 Vol. 25 (24): 96-98 [
Abstract
] (
211
)
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99
Effect observation of continuous femoral nerve block guided by nerve stimulator for postoperative analgesia of knee joint
WANGWei-ku;LYU Zhen-jiang
Objective
To observe the effect of continuous femoral nerve block guided by nerve stimulators for postoperative analgesia in knee joints.
Methods
A total of 100 patients performed with postoperative analgesia for the lower extremities from February to December in 2017 were selected.They were equally divided into two groups by a random number table method,50 cases in each group.In the reference group,continuous intravenous analgesia was used,while in the observation group,continuous femoral nerve block guided by nerve stimulator was adopted.The clinical indicators,visual analogue scale (VAS),Ramsay sedation score,and incidence of adverse reactions in the two groups were compared.
Results
There was no significant difference in heart rate(HR)or oxyhemoglobin saturation(SpO
2
)between the two groups(P＞0.05）.The systolic blood pressure (SBP)and diastolic blood pressure (DBP)were higher in the reference group than in the observation group and the difference was statistically significant(P＜0.05）.The VAS scores before treatment in both groups were not displayed statistical significance between the two groups (P＞0.05）.The VASscores 6,12,36 and 48 h after treatment in the observation group were all lower than those in the reference group and the difference was statistically significant(P＜0.05）.There was no significant difference in VAS scores before and after treatment in the observation group(P＞0.05）.The scores of the reference group at different timepoints after treatment were all higher compared with those before treatment and the difference was statistically significant(P＜0.05）.Ramsay sedation scores before treatment in both groups were not displayed statistical significance (P＞0.05）.The Ramsay sedation scores 6,12,36 and 48 h after treatment in the observation group were all lower than those in the reference group and the difference was statistically significant(P＜0.05）.What′s more,the Ramsay sedation scores at different timepoints after treatment in the two groups were higher compared with those before treatment and the difference was statistically significant(P＜0.05）.The incidence of adverse reactions in the observation group was lower than that in the reference group,and the difference was statistically significant(P＜0.05）.
Conclusion
The continuous femoral nerve block guided by nerve stimulator is effective for postoperative analgesia of knee joint.It is safe and can be widely used and promoted in clinical practice.
2018 Vol. 25 (24): 99-102 [
Abstract
] (
181
)
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9
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103
Clinical value of 3.0 T magnetic resonance DWI imaging in differential diagnosis of benign or malignant prostate lesions
XU Zhong-jun;LIU Sheng;HU Lu-nv;LI Zhen-hua;XU Hong-yu;XIAORi-hai
Objective
To explore the clinical value of 3.0 T magnetic resonance (MR)diffusion weighted imaging(DWI)in the differential diagnosis of benign or malignant prostate lesions.
Methods
From June 2015 to October 2017,routine MR and DWI imaging data of 50 patients with prostatic lesions who were admitted in our hospital were collected.All cases were confirmed by pathology.They were equally divided into benign group and malignant group.The DWI signal and apparent diffusion coefficient(ADC)values of benign and malignant prostate lesions were comparatively analyzed.The receiver operating characteristic curve(ROC)was used to obtain the best diagnostic demarcation point for ADC.
Results
The benign prostatic lesions showed contoured signal on DWI and a slight decrease in ADC.On the other hand,DWI showed a high signal in prostate cancer and a significance decrease in ADC.The ADC values of benign and malignant prostate lesions were(0.913±0.147）×10
-3
mm
2
/s and(0.573±0.160）×10
-3
mm
2
/s,respectively with a significant difference between the two(P=0.000）.The area under the ROCcurve of prostatic lesions was0.963 based on ADC value with a threshold of 0.779×10
-3
mm
2
/s.The sensitivity was 80%and specificity was 96%.
Conclusion
3.0 T MR DWI imaging has a high clinical value in judging the benign and malignant prostate lesions.
2018 Vol. 25 (24): 103-105转111 [
Abstract
] (
180
)
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23
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106
Effectiveness of combination of application of multi-slice spiral CT angiography and hypotonic enterography in diagnosis of small intestinal hemorrhagic disease
HU Hai-jing; PENG Rong-hua; GAO Feng; XU Xin-chao
Objective
To study the effectiveness of combination of application of multi-slice spiral CT angiography(MSCTA)and hypotonic enterography in diagnosis of small intestinal hemorrhagic diseases.
Methods
Altogether 45 cases of clinically suspected small intestinal hemorrhagic diseases who were hospitalized in Nanhai District People′s Hospital of Foshan,from August 2016 to August 2017 were retrospectively analyzed and examined by using MSCTA combined with hypotonic enterography.Before scanning,all the patients orally took isosotic mannitol and intramuscular anisodamine (654-2)on the basis of full filling of the intestinal cavity and then underwent multi slice spiral CT small intestinal angiography.The contrast effect and detection rate of 45 cases were analyzed.
Results
The duodenum,jejunum,ileum and ileocecal filling were good,with low density isosotic liquid in the intestinal cavity;the fat in the intestinal cavity,intestinal wall and the surrounding intestine were clear,and the mesenteric vessels could be shown to the level of 3 or above.Pathological changes were found by the surgery and endoscopic biopsy in 32 cases.The lesion detection rate by using CT was 86.1%(31/36),and the coincidence rate was 87.5%(28/32)in contrast with pathology.
Conclusion
Application of combination of multi slice spiral CT angiography (MSCTA)and hypotonic enterography has a good effect in the diagnosis of small intestinal hemorrhagic diseases.It is of great significance in guidance of the selection of clinical treatment scheme,evaluation of the surgical effect and estimation of the prognosis,which has high clinical application and popularization value.
2018 Vol. 25 (24): 106-108转114 [
Abstract
] (
201
)
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14
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109
Electrocardiogram observation of 260 cases of chronic pulmonary heart disease
ZHANG Mei-ying;WU Wen-sheng
Objective
To analyze the key points of electrocardiogram diagnosis of patients with chronic pulmonary heart disease.
Methods
260 cases of chronic pulmonary heart disease admitted to our hospital from January 2014 to December 2016 were selected.All patients were analyzed by 12 lead electrocardiogram,and all other clinical data of patients were retrospectively analyzed.
Results
The pulmonary Pwave was detected in 174 cases(66.9%),abnormal PTFV1 in 81 cases(31.0%),130 cases(50.0%)in the right axis,56 cases(24.3%)in low voltage,and 138 cases in the clockwise transposition(53.1%).Arrhythmia in 156 cases(60.0%),common in atrial arrhythmia,ST-T changes 80 cases(30.8%).
Conclusion
The electrocardiogram of patients with chronic pulmonary heart disease has certain characteristics.According to the patients′symptoms,signs and laboratory tests,combined with the characteristic changes of electrocardiogram,it is valuable for the diagnosis and treatment of cor pulmonale.
2018 Vol. 25 (24): 109-111 [
Abstract
] (
154
)
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31
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112
Application value of contrast-enhanced ultrasonography on the diagnosis of postpartum placental implantation in patients with gestational hypertension
LI Yan;LIN Xiao-yan
Objective
To analyze the significance of contrast-enhanced ultrasound(UC)in the diagnosis of postpartum placenta accreta in patients with gestational hypertension.
Methods
A total of 47 cases of hypertensive patients with gestational hypertension diagnosed in our hospital from November 2015 to November 2016 were selected as the objects.UC was used as examine method and the results could explore its significance in diagnosing of placental invasion.
Results
The rate of placental invasion using pathologic diagnosis was 27.66%,and it was 23.40%by using UCthe difference was no statistically significant(P＞0.05).The blood pressure were compared before and after UC,which did not appear large fluctuations,the difference was no statistically significant(P＞0.05）.
Conclusion
The rate of postpartum placental implantation diagnosed by UC and pathologic is close,which is worthy promoting in clinical.
2018 Vol. 25 (24): 112-114 [
Abstract
] (
200
)
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23
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115
Diagnostic value of conventional and dynamic electrocardiogram in children with viral myocarditis
KANG Wei
Objective
To compare the application and value of conventional and dynamic electrocardiogram （ECG）in the diagnosis of children with viral myocarditis(VMC).
Methods
From March 2017 to March 2018,120 children with suspected VMC were selected as experimental subjects.They were all performed with conventional and dynamic ECGs.After that,the specificity and sensitivity,diagnostic accuracy,missed diagnosis,misdiagnosis rate,and accuracy in image features of the two diagnostic methods were compared.
Results
The diagnostic sensitivity,specificity,diagnostic accuracy of atrioventricular block in degreeⅠ,and diagnostic accuracy of ventricular premature beatsby dynamic ECGwere 95.00%,95.00%,95.45%,and 95.45%,which were higher than those by the conventional ECG diagnosis,accounting for 75.00%,65.00%,81.82%,and 81.82%respectively with statistical significance(P＜0.05）.
Conclusion
Dynamic electrocardiographic examination in children with VMCis of high value to increase the clinical diagnostic accuracy.
2018 Vol. 25 (24): 115-117 [
Abstract
] (
191
)
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24
)
118
The application value of echocardiography in the diagnosis of hypertensive heart disease
FU Xiao-ding
Objective
To study the clinical value of echocardiography in the diagnosis of hypertensive heart disease.
Methods
A total of 78 cases of hypertensive heart disease were confirmed in our hospital from August 2015 to August 2017,and 78 cases of healthy people who received healthy physical examination in the same period were defined as the study group and the control group.Echocardiography was performed on the two groups.Echocardiography E/A,LVEF,LAD,LVMM,LVEDV levels and positive results of the two groups were compared.
Results
The ultrasonic cardiogram E/A and LVEF of the study group were lower than those the control group,LAD,LVMM and LVEDV were higher than those of the control group,the differences were statistically significant(P＜0.05）.And the positive rate of the five indexes of E/A,LVEF,LAD,LVMM and LVEDV in echocardiography were higher than that of the control group,the differences were statistically significant(P＜0.05）.
Conclusion
The indexes of echocardiography in patients with hypertensive heart disease are obviously different from those of healthy people.This technique can be used in the diagnosis of hypertensive heart disease.
2018 Vol. 25 (24): 118-120 [
Abstract
] (
181
)
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121
Clinical effect evaluation of Butylphthalide Soft Capsules plus Edaravone in the treatment of cerebral infarction
XIE Jiang;ZHU Jing-chun
Objective
To investigate the clinical effect of Butylphthalide Soft Capsules plus Edaravone in the treatment of cerebral infarction.
Methods
A total of 162 patients with cerebral infarction who were admitted to our hospital from December 2015 to July 2016 were selected as subjects.They were divided into control group (n=81)and observation group (n=81)according to the random comprehensive balance method.The control group was treated with Edaravone,while in the observation group,Butylphthalide Soft Capsules was added on the basis of the control group.The efficacy of drug use in two groups was compared.
Results
There was no significant difference between two groups before treatment in indicators (P>0.05).The limb function scores (Fugl-Meyer),daily living ability scores (Barthel index),and montreal cognitive assessment(MOCA)scores in two groups after treatment were higher than those before treatment,NIH stroke scale(NIHSS)scores after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).Fugl-Meyer scores,Barthel index and MOCA scores after treatment in the observation group([92.6±0.9],[82.0±1.4],[23.0±0.6]points)were higher than those in the control group([84.6±0.6],[72.9±2.0],[20.2±1.0]points),NIHSSscores after treatment in the observation group ([11.1±0.9]points)were lower than those in the control group([20.4±1.2]points),and the differences were statistically significant(P<0.05).The total effective rate of the treatment in the observation group was 95.06%,which was significantly higher than that in the control group accounting for 81.48%,and the difference was statistically significant(P<0.05).There was no significant difference in scores of life quality between two groups before treatment(P>0.05).Scores of life quality after treatment in two groups were higher than those before treatment,and the differences were statistically significant(P<0.05).Scores of life quality after treatment in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).
Conclusion
For patients with cerebral infarction,on the basis of Edaravone treatment,combination of Butylphthalide Soft Capsules can obtain a remarkable effect by improving patients′neurological,cognitive,and motor function as well as the quality of life,and enhance patients′activity of daily living,which is worthy of further exploration in the clinic.
2018 Vol. 25 (24): 121-123转126 [
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214
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Clinical effect observation of Vitamin E in the treatment of pelvic pain caused by endometriosis
XIAO Jing;HUANG Jia;GUO Chen;JIANG Ru
Objective
To explore the clinical value of Vitamin E in the treatment of pelvic pain caused by endometriosis.
Methods
Altogether 60 patients with endometriosis and accompanied with pelvic pain who were treated in our hospital from February 2016 to May 2017 were selected as objects and divided into experiment group (n=30)and control group (n=30)according to the simple randomization method.The control group was treated with Drospirenone and Ethinylestradiol Tablets,while the experiment group was treated with Vitamin E on the basis of the control group.The dysmenorrhea scores,intercourse pain scores,pelvic pain scores and adverse reactions after treatment were compared between two groups.
Results
The scores of dysmenorrhea,intercourse pain and pelvic pain after treatment in two groups were lower than those before treatment,with statistically significant differences (P<0.05).The score of pelvic pain after treatment in the experiment group was significantly lower than that in the control group,with statistically significant difference(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).
Conclusion
Application of Vitamin E in the treatment of pelvic pain caused by endometriosis can reduce the patients′symptoms and improve their prognosis.
2018 Vol. 25 (24): 124-126 [
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195
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Clinical effect observation of Vitamin E in the treatment of pelvic pain caused by endometriosis
XIAO Jing;HUANG Jia;GUO Chen;JIANG Ru
Objective
To explore the clinical value of Vitamin E in the treatment of pelvic pain caused by endometriosis.
Methods
Altogether 60 patients with endometriosis and accompanied with pelvic pain who were treated in our hospital from February 2016 to May 2017 were selected as objects and divided into experiment group (n=30)and control group (n=30)according to the simple randomization method.The control group was treated with Drospirenone and Ethinylestradiol Tablets,while the experiment group was treated with Vitamin E on the basis of the control group.The dysmenorrhea scores,intercourse pain scores,pelvic pain scores and adverse reactions after treatment were compared between two groups.
Results
The scores of dysmenorrhea,intercourse pain and pelvic pain after treatment in two groups were lower than those before treatment,with statistically significant differences (P<0.05).The score of pelvic pain after treatment in the experiment group was significantly lower than that in the control group,with statistically significant difference(P<0.05).There was no significant difference in the total incidence of adverse reactions between two groups(P>0.05).
Conclusion
Application of Vitamin E in the treatment of pelvic pain caused by endometriosis can reduce the patients′symptoms and improve their prognosis.
2018 Vol. 25 (24): 127-129 [
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198
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Effect and efficacy analysis of Alprostadil on early proinflammatory cytokines in patients with severe acute pancreatitis
YONGXue-wei;ZHANGLi
Objective
To investigate the effect and efficacy of Alprostadil on early proinflammatory factors in patients with severe acute pancreatitis.
Methods
Sixty-six patients with severe acute pancreatitis who were admitted to our hospital from September 2016 to December 2017 were selected as the study subjects.They were divided into the control group (33 cases)and the observation group (33 cases)according to a double-blind method.The control group was treated with sodium chloride or glucose solution,and the observation group was given Alprostadil.The coagulation function,inflammatory factors,and symptom improvement were compared between two groups.
Results
There were no significant differences in the levels of platelet distribution width(PDW)and Mean platelet volume(MPV)before treatment between two groups(P>0.05).The levels of PDW and MPV in two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of PDW and MPV after treatment in the observation group([12.21±1.05]%,[8.15±0.64]fl)were lower than those in the control group([15.54±1.31]%,[10.28±0.36]fl),and the differences were statistically significant(P<0.05).There were no significant differences in the levels of IL-1β,IL-6,TNF-α before treatment between two groups(P>0.05).The levels of IL-1β,IL-6,TNF-α in two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of IL-1β ([32.63±7.4]ng/L),IL-6([61.05±11.94]ng/L),TNF-α ([62.26±17.18]ng/L)after treatment in the observation group were lower than those in the control group([75.59±11.05],[76.69±10.28],[78.58±12.05]ng/L),and the differences were statistically significant(P<0.05).The recovery time of blood amylase ([4.10±1.25]d),intestinal function ([3.18±1.04]d)and the relief time of abdominal pain ([3.15±1.19]d)in the observation group were shorter than those in the control group （[6.65±1.28],[5.37±1.23],[5.01±1.12]d）,and the differences were statistically significant(P<0.05).
Conclusion
In the treatment of severe acute pancreatitis,the application of Alprostadil can reduce the degree of inflammatory reaction in patients and promote the early disappearance of various symptoms,with reliable effect.
2018 Vol. 25 (24): 130-132 [
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184
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Clinical effect comparison of Mosapride and Domperidone in the treatment of functional dyspepsia
LI Chao-wei
Objective
To investigate the clinical effect of Mosapride and Domperidone in the treatment of functional dyspepsia.
Methods
Altogether 90 patients with functional dyspepsia treated in our hospital from March 2016 to November 2017 were selected as study objects and they were divided into the Domperidone group (n=45)and the Mosapride group (n=45)according to the random number table method.The Domperidone group was given Domperidone,and the Mosapride group was given Mosapride.The control rate of functional dyspepsia,the scores of functional dyspepsia and life quality before and after treatment,the disappearance time of abdominal distension and hernia symptoms,the remission time of acid vomiting,and the rate of adverse drug reaction were compared between two groups.
Results
The total control effective rate of functional dyspepsia in the Mosapride group was higher than that in the Domperidone group,and the difference was statistically significant(P<0.05).There were no significant differences in the scores of functional dyspepsia and life quality before treatment between two groups(P>0.05).The scores of functional dyspepsia after treatment in two groups were lower than those before treatment,the scores of life quality were higher than those before treatment,and the differences were statistically significant(P<0.05).The score of functional dyspepsia after treatment in the Mosapride group was lower than that in the Domperidone group,the score of life quality was higher than that in the Domperidone group,and the differences were statistically significant(P<0.05).The disappearance time of abdominal distension and hernia symptoms,and the remission time of vomiting acid in the Mosapride group were shorter than those in the Domperidone group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).
Conclusion
The effect of Mosapride in the treatment of functional dyspepsia is definite.It can significantly improve symptoms,significantly promote life quality of patients,and has no serious adverse reactions,which is safe and effective,and worthy of promotion and application.
2018 Vol. 25 (24): 133-135 [
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229
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Professor Fan Yue-guang′s experience in the treatment of osteoarthritis of the knees with the theory of kidney deficiency and blood stasis
LINZi-lin;ZHENGLi-qin; ZHENGYong-ze;ZENGJian-chun;LIPeng-fei;LIMu-sheng;FANYue-guang
In the theory of traditional Chinese medicine,osteoarthritis of the knees(KOA)is ascribed to the category of“knee pain”, “bone impediment”, “impediment syndrome”,etc.Professor Fan Yue-guang proposes that the location of KOA is in the sinew and bone,whose root cause of disease is kidney deficiency,manifestation with blood stasis.Block of blood stasis leads to the symptom of pain,thus KOA should be treated both manifestation and root cause of disease.Therefore,the prescriptions which can tonify kidney and activate blood should be used,tonifying kidney and strengthening bone for the root,activating blood and relieving pain for the manifestation.Bushen Huoxue Recipe(including Rehmannia Glutinosa,Psoralea Corylifolia,Salvia Miltiorrhiza,Ligusticum Wallichii,Fructus Lycii)has significant effect in anti-inflammatory,pro-vascularization,chondrocyte proliferation and repair,and has achieved satisfactory therapeutic effect in long-term clinical application,which is worthy of learning and promotion.Professor Fan Yueguang′s experience in treating KOA from the thought of kidney deficiency and blood stasis is summarized in this article.
2018 Vol. 25 (24): 136-138 [
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162
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Effect analysis of Shengmaisan Decoction in the treatment of diabetes mellitus complicated with coronary heart disease angina pectoris with deficiency of qi and yin
XU Zhao
Objective
To study the effect of Shengmaisan Decoction in the treatment of diabetes mellitus complicated with coronary heart disease angina pectoris with deficiency of qi and yin.
Methods
A total of 80 patients with diabetes mellitus and coronary heart disease angina pectoris treated in our hospital from April 1,2016 to April 2,2017 were selected as the research objects.They were divided into the control group and the observation group according to the computer random method,with 40 cases in each group.The control group was treated with the Compound Danshen Dripping Pills,and the observation group was treated with Shengmaisan Decoction.Dynamic electrocardiogram,clinical effect,blood lipid index,levels of blood glucose,C-reactive protein and homocysteine were compared between two groups.
Results
There was no significant difference in the dynamic electrocardiographic is chemic ST-T changes between two groups before treatment(P>0.05).The change of dynamic electrocardiographic ischemic ST-T after treatment in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in blood lipid index before treatment between two groups(P>0.05).The levels of total cholesterol,triglyceride and low-density lipoprotein of two groups after treatment were lower than those before treatment,the level of high-density lipoprotein was higher than that before treatment,and the differences were statistically significant(P<0.05).The levels of total cholesterol,triglyceride and low-density lipoprotein after treatment in the observation group were lower than those in the control group,the level of high-density lipoprotein was higher than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the level of blood glucose between two groups before treatment(P>0.05).The levels of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin after treatment in two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin after treatment in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of C-reactive protein and homocysteine between two groups before treatment(P>0.05).The levels of C-reactive protein and homocysteine after treatment in two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).The levels of C-reactive protein and homocysteine after treatment in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).
Conclusion
Shengmaisan Decoction is effective in the treatment of patients with diabetes mellitus and coronary heart disease angina pectoris,which can effectively improve the levels of blood glucose,blood lipid and angina pectoris symptoms.
2018 Vol. 25 (24): 139-142 [
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183
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Quantitative detection results analysis of TORCH using chemiluminescence in women of childbearing age in Shishi area
CAI Dong-hua;HE Wei-dong; LIU Ming-chun;CHEN Qiu-yue;QIU Xiao-wei;YANG Bao-xu
Objective
To analyze the TORCH quantitative detection results for women of childbearing age at pre pregnancy and early pregnancy period,and to understand the TORCH infection of them to provide a basis for treatment health care measures at pre pregnancy and early pregnancy period in the region.
Methods
A total of 1120 women of childbearing age given TORCH screening at pre pregnancy and early pregnancy period in our hospital from January 2015 to December 2017 were selected as study objects.Among them,there were 503 cases at pre pregnancy period,617 cases at early pregnancy period,chemiluminescence immunoassay(CLIA)was used to detect quantificationally the IgM and IgG antibodies of Toxoplasma(TOX),Rubella virus(RV),Cytomegalovirus(CMV),and Herpes simplex virusⅠ+Ⅱ (HSV-Ⅰ+Ⅱ),and the test of the results were analyzed.
Results
The positive rate of IgM for TOX,RV,CMV and HSV-Ⅰ+Ⅱ IgM was 0.18%,0.80%,0.89%and 19.64%respectively,while the positive rates of IgG was 1.88%,79.91%,85.98%and 73.93%respectively.The positive rate of IgM,IgG for TOX and IgM,IgG for HSV-Ⅰ+Ⅱ between pre pregnancy and early pregnancy period group were not significantly different(P>0.05).The positive rates of RV-IgM,IgG in the pre pregnancy group were higher than those in the early pregnancy period group,and the positive rates of CMV-IgM,IgG were lower than those in the early pregnancy period group,and the differences were statistically significant(P<0.05).
Conclusion
CLIA used to quantificationally detect and screen TORCH for women of childbearing age at pre pregnancy and early pregnancy period can understand the status of the TORCH infection in time and the infection is definitely diagnosed,and the individualized recommendations and treatment methods are proposed to avoid adverse pregnancy outcomes,reduce the incidence of congenital malformations in children,and improve the quality of birth population in the region.
2018 Vol. 25 (24): 143-145转148 [
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188
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The clinical significance of serum and urinaryβ
2
-microglobulin and high sensitivity C-reactive protein level in early type 2 diabetic nephropathy
2-microglobulin and high sensitivity C-reactive protein level in early type 2 diabetic nephropathy[J]. 中国当代医药, 2018,25(24): 146-148')" href="#">
MA Jing-wei;SITU Yi-jian;WEN Zhuo-hui;WANG Xian-gui
Objective
To explore the clinical significance of serum and urinaryβ
2
-microglobulin and high sensitivity C-reactive protein level in early type 2 diabetic nephropathy.
Methods
Sixty patients with early type 2 diabetic nephropathy treated in our hospital from June 2016 to June 2017 were selected as the observation group and they were divided into mild injury group(n=20),moderate injury group(n=20)and severe injury group(n=20)according to the severity of the disease.Sixty normal volunteers were selected as the control group.The serum and urinaryβ
2
-microglobulin and high sensitivity C-reactive protein level among the groups were detected.
Results
In the observation group,serum and urinaryβ
2
-microglobulin and high sensitivity C-reactive protein level in mild injury group,moderate injury group and severe injury group were higher than those of the control group(P<0.05).The above index level of the severe injury group was higher than that of the moderate injury group and the mild injury group;the above index level of the moderate injury group was higher than that of the mild injury group,and the differences were statistically significant(P<0.05).
Conclusion
serum and urinaryβ
2
-microglobulin and high sensitivity C-reactive protein have certain clinical value in the diagnosis of diabetic nephropathy.
2018 Vol. 25 (24): 146-148 [
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203
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Blood coagulation function and platelet change in patients before and after massive blood transfusion
MIAOXiao-hua;CHEN Juan;WU Chun-mei;XIAO Ai-ping;ZHENGMin
Objective
To observe the blood coagulation and platelet change in patients before and after massive blood transfusion,and to provide a certain basis for clinical transfusion,to ensure the safety of blood transfusion.
Methods
A total of 46 patients who received with 24 h massive infusion of suspended erythrocyte blood in our hospital from February 2015 to February 2017 were randomly selected to include the study,the medical records were retrospective analyzed,and the blood coagulation and platelet change in patients were recorded before and after blood transfusion.
Results
FIB and Pa after blood transfusion were lower than those before blood transfusion,and the indexes of TT,APTT,PT and INR after transfusion were all higher than those before blood transfusion(P<0.01).Hct and HGB after transfusion were all higher than those before blood transfusion,and PLT was lower than that before blood transfusion(P<0.01).
Conclusion
After patients receiving massive blood transfusion,and the possibility of PLT undergoing dilution reduction is larger.In the process of blood transfusion,it is necessary to monitor every target of the human body in time,if the platelet index<50×10
9
/L,it is necessary to supplement the platelet in time and avoid coagulation dysfunction due to lower platelet index.
2018 Vol. 25 (24): 149-151 [
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198
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152
Investigation of using LIS system sample time flow function to guarantee the inspection quality of time limited samples
ZHOU Jing-xin; WANG Xue-ji
Objective
To explore the value of using LISsystem sample time flow function to guarantee the inspection quality of time limited samples.
Methods
The urine routine,blood ammonia and blood gas analysis collected by inpatient department of department of clinical laboratory in People′s Hospital of Jilin City from July to December 2017 and from January to June 2017 were selected as time-limited samples,and there were 25 679,912,5117 cases,and 24 313,867,4895 cases.From January to June 2017,the routine standard operation process was used to detect the time limited samples while from July to December 2017,the setting of pre-warning time was added on the basis of routine standard operation process:the pre-warning time of urine routine was 90 min,blood ammonia was 30 min,and blood gas analysis was 10 min.The coincidence rate,median and 90%digits of turnaround time (TAT)for time limited samples in different time periods were compared.
Results
The coincidence rates of TAT in urine routine,blood ammonia and blood gas analysis from July to December 2017 was 98.7%,97.1%and 98.3%respectively,which was significantly higher than that from January to June 2017 (90.5%,80.5%and 88.6%)respectively (P<0.05).From January to June 2017,the median and 90%digits of TAT in urine was 32.6,62.5 min rspectivley,blood ammonia was 20.6,45.8 min,and blood gas analysis was 20.6,27.8 min,which were shorter than those from January to June 2017 (48.5,88.6 min;32.6,55.7 min;23.8,29.1 min)(P<0.05).
Conclusion
The sample time flow function of the LISsystem can guarantee the time detection requirement and detection quality of time limited samples.
2018 Vol. 25 (24): 152-154 [
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211
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Clinical effect analysis of fine management in orthopedic nursing care
CHEN Hong-man;WANG Zhi-hong
Objective
To explore the application value and effect of fine management in orthopedic nursing safety administration.
Methods
A total of 816 patients from June 2013 to May 2014 were admitted to our departmental with fine management compared with 804 patients who did not undergo intensive management from June 2012 to May 2013.The quality of comprehensive care,the incidence of adverse events,the patient′s satisfaction for nursing work were evaluated the role of nursing safety management in the implementation of fine management before and after the fine management.
Results
The nursing staff′s overall nursing,ward management,basic nursing,nursing documents,nosocomial infections,health education and nursing error scores after fine management were significantly increased compared with the pre-implementation(P<0.05）,and the incidence of adverse eventswas significantly lower than that before implementation(P<0.05）.Patient satisfaction rate was significantly higher than that before the implementation of fine management,the differences were statistically significant(P<0.05）.
Conclusion
The implementation of fine management in orthopedic care can improve the quality of comprehensive nursing,reduce the occurrence of bad care events,improve patient satisfaction with nursing work and promote the development of orthopedic nursing work in safe and orderly manner.
2018 Vol. 25 (24): 155-158 [
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203
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Application effect of PDCA circulation management on nursing management in operation room
LI Yin
Objective
To explore the pragmatic application effect of PDCA cycle management in operation-room nursing management.
Methods
Thirty-six nurses accepted plan-do-check action (PDCA)cycle management in operation room from May 2014 to May 2015 were selected as the subjects of this study.PDCA cycle management was used to manage nurse′s work in the operating room from stages of planning,doing,checking,and action.The comprehensive evaluation results were compared and analyzed before and after PDCA cycle management.
Results
After applying PDCA cycle management,the scores of quality control,nursing safety,document management,humanistic care,environmental management,and disinfection and isolation in these participants were all higher than those before management,and the difference was statistically significant(P<0.05).After the implementation of the PDCA cycle management,satisfaction on nursing work by physicians was also much higher than that before,and the difference was statistically significant(P＜0.05）.
Conclusion
The application of PDCA cycle management in operation-room nursing management can improve the nursing quality.
2018 Vol. 25 (24): 159-161 [
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213
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Observation effect of individualized health education on outpatient Peripherally-Inserted Central Catheterization in tumor patients
FAN Yan-hua
Objective
To explore the application effect of individualized health education on the maintenance of outpatient Peripherally-Inserted Central Catheterization (PICC)in tumor patients.
Methods
A total of 132 patients who underwent the maintenance of PICC in Department of Outpatient in our hospital from May 2016 to May 2017 were selected as the subjects,and divided into the observation group and the control group according to the random number method,with 66 cases in each group.The conventional health education was carried out in the control group,and the observation group was given individualized health education on the basis of the control group.The PICC maintenance knowledge,PICC self-management ability and PICC-related complications were compared between the two groups.
Results
At post-interventional 3 months,the PICC maintenance score of the observation group ([17.67±2.13]points)was higher than the control group([13.54±1.86]points).The PICC self-management ability score of observation group([29.47±0.93]points)was higher than that of the control group ([26.08±0.64]points).The total incidence PICC-related complication of observation group(9.09%)was lower than that of the control group(22.72%),with statistically significant difference (P<0.05).
Conclusion
Personalized health education can promote patients′PICC maintenance knowledge,improve their PICC self-management ability,and reduce the incidence of PICC-related complications so as to improve the quality of life for patients with PICC.
2018 Vol. 25 (24): 162-165 [
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170
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The influence of comprehensive community intervention on essential hypertension
LIU Yi-hua
Objective
To explore the influence of comprehensive community intervention on essential hypertension.
Methods
A total of 200 essential hypertension patients from 2015 to 2016 in our community were selected as the subjects,and established their health archive.The blood pressure,glucose,lipid metabolism and other biochemical indexes were recorded and taken community-based integrative intervention for 1 year.The awareness rate,treatment condition and control condition before and after intervention were compared.
Results
After community-based integrative intervention,the awareness rate of hypertension were improved,and the treatment rate was increased from 32%to 68%,the average SBPwent from(168.52±8.66)mmHg and the rate of blood pressure control was increased from 24%to 52%.The blood-lipid and glucose levels were also improved.The difference between two groups showed statistical significance(P<0.05).
Conclusion
Taken community-based integrative intervention on essential hypertension patients can improve the awareness rate,disease control rate,the health of patients and their life quality obviously.It is worth to be popularized and applied.
2018 Vol. 25 (24): 166-168 [
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163
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The design of instructional experiment of preparation method of scutellarin
TAI Zhi-gang;DAI Wei-feng;LIN Lian-bing
Pharmaceutical technology is the important specialized curriculum of the pharmaceutics engineering.It is more important to carry out experimental design of the course to improve the teaching efficiency of pharmaceutical technology.The resources of Erigeron breviscapus is abundant in Yunnan,Kunming University of Science and Technology,School of Life Science and Technology conducted the teaching experiments of the preparation method of scutellarin from Erigeron breviscapus.Highly purified scutellarin can be obtained from the characteristic plant-Erigeron breviscapus by reflux extraction,extraction,polyacrylamide column chromatography and crystallization.The experiment is easy to operate.The experimental content covers the course content of raw material pretreatment,extraction,separation and purification,and drying.Through the above experimental teaching,the teaching quality of pharmaceutical technology can be effectively improved.
2018 Vol. 25 (24): 169-171转175 [
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147
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The effect of different teaching methods on the basic life support training for new nurses
LI Ya-juan; HAO Gui-lan
Objective
To compare the effect of different teaching methods in new nurses′basic life support(BLS)training.
Methods
From January 2016 to December 2017，60 new nurses in Chinese Medicine Hospital of Changping District wereselected asresearch subjects.The28 new nursesof control group were trained by traditional teaching methodsfrom January 2016 to December 2017,while the32 new nursesof observation group were trained by integrated teachingmethod.Assessmentsand questionnairesurveyswereconducted before,immediately after,and 3 monthsafter thetraining.The theoretical performance,operating performance,passing rate,and the satisfaction of the two groups of new nurses on the training methods were contrasted before,immediately after,and 3 months after the training.
Results
Immediately after the training and 3 months after the training,the theoretical and operational scores of the two groups of nurses were higher than those before the training,and the differences were statistically significant(P<0.05).Three months after training,the theoretical and operational performances of both groups of nurses were lower than that immediately after training,and the differences were statistically significant(P<0.05).The difference of passing rate immediately after the training and 3 months after the training was not statistically significant(P>0.05).There was no statistically significant difference between the two groups in the theoretical,operation results,and the passing rate before and immediately after the training (P>0.05).After 3 months of training,the theoretical scores,operating results,and examination pass rates of observation group nurses were higher than those of the control group,and the difference was statistically significant(P<0.05).The satisfaction of the new nurses in observation group was higher than that in the control group,the difference was statistically significant(P<0.05).
Conclusion
Both of the teaching methods can help to improve nurses′theory and performance level in the short-term and mid-term training of basic life support for new nurses.However,the comprehensive teaching methods have a significantly longer-term effect on maintaining BLStraining effect than traditional teaching methods and more satisfied by the nurses,which is worth further promotion and implementation.
2018 Vol. 25 (24): 172-175 [
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182
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Key strategy analysis of reducing the clinical blood test error
LIU Li;CAODao-jun
Objective
To analyze the causes of the errors in clinical blood test,and carry out the key strategy in order to reduce the error events.
Methods
A total of 570 specimens were selected from all these clinical blood examinations in our hospital from January to June 2017,which were evenly divided into two groups,285 cases in each group.The control group was provided with conventional measure for inspecting blood examinations,and the research group was with key strategy.After taking different meansures,the incidence of errors was compared.Meanwhile,the causes of blood sample errors were analyzed and summarized.
Results
The main causes of occurring errors included inspectors themselves,process of collecting blood samples,blood samples delivering,and process of inspecting.The error rate was 2.11%in research group,while 18.95%in control group.The error rate in the research group was lower than that in the control group,and the difference was statistically,significant(P＜0.05）.
Conclusion
The error events in the clinical blood test will bring certain influence for later treatment,and may cause harm to the body,so it is necessary to analyze the error causes in the blood test,and provide with key strategy in order to avoid jeopardizing the body and improve the effectiveness of inspection.
2018 Vol. 25 (24): 176-178 [
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201
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179
Application value of predictive nursing risk management in controlling hospital infection rate of preterm infants
CHENG Yan-feng
Objective
To explore the influence of risk management of predictive care in preterm infants on reducing the risk of nosocomial infection.
Methods
A total of 100 neonates in our department from January to October in 2017 were divided into experimental group (n=50)and control group (n=50)using block randomization.In the control group,conventional nursing as an intervention was used,while in the experimental group,predictive nursing risk management as an intervention was adopted.The probability of nosocomial infection,incidence of adverse events,and difference of family members′satisfaction were compared between the two groups.
Results
The rate of nosocomial infection was 8.00%in the experimental group,significantly lower than that in the control group accounting for 24.00%,and the difference was statistically significant(P<0.05）.The incidence of adverse events in the experimental group was 20.00%,which was significantly lower than that in the control group accounting for 38.00%,and the difference was statistically significant(P<0.05）.The satisfaction score of the family members in the experimental group was greatly higher than that in the control group,and the difference was statistically significant(P<0.05）.
Conclusion
Preterm infants receiving predictive nursing risk management can effectively reduce their chance of nosocomial infection and increase their family members′satisfaction with care,which is of great significance.
2018 Vol. 25 (24): 179-181 [
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158
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182
The influence of three person program blood glucose management on blood glucose control and insulin injection in diabetic patients
XIE Shu-ying;ZHANG Ling;ZHANG Qiu-ping
Objective
To observed the effect of three person program blood glucose management on blood glucose control and insulin injection technology in diabetic patients.
Methods
100 patients of type 2 diabetes mellitus(T2DM)with initial basal insulin were selected in our department of Endocrinology from August 2016 to June 2017,according to the random number table method,the patients were divided into observation group and control group,50 cases in each group.The control group was received conventional education,and the observation group was received with the implementation of three person program blood glucose management in patients with project management,The blood glucose,insulin injection technology and the occurrence of adverse reactions of two group patients were observed before and after 12 weeks management in each group.
Results
A total of 100 patients were enrolled and 94 patients completed 12 weeks of follow-up.After 12 weeks intervention,two groups of patients of fasting blood glucose (FPG),2 h postprandial blood glucose(2 hPG)and glycosylated hemoglobin(HbA1c)were significantly decrease than those of before treatment(P＜0.01）,the blood glucose control,insulin injection technology in observation group were significantly higher than that in the control group,the incidence of adverse reaction was lower than that in the control group (P＜0.05）.
Conclusion
Three person program blood glucose management can not only help diabetics improve insulin injection technology,but also can make patients′blood glucose control well.
2018 Vol. 25 (24): 182-184 [
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214
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185
Design and clinical application of pregnant and delivery woman maternity clothes
XIAO Lang-hua;LIU Gui-rong;ZHANG Gui-lian;LU Rui-ying
Objective
To explore the clinical value of pre-and post-partition maternal births.
Methods
A total of 400 pregnant women were hospitalized in the maternity ward of our hospital from January 2015 to December 2016.They were divided into two groups according to the hospitalization number and double number,200 cases in each group.In the control group,the mothers were wore general maternal sickness clothes,and the observation group was wore maternity clothes before and after wearing.A survey was conducted on two groups of pregnant women to find out the maternal comfort,wear time,maternal breastfeeding,style satisfaction and other issues.
Results
The maternal comfort of the observation group was significantly higher than that of the control group.The wear time was significantly shorter than that of the control group.The maternal lactation related indicators were significantly better than the control group,and the style satisfaction was significantly higher than that of the control group.The differences were statistically significant(P＜0.05）.
Conclusion
It is effective to increase maternal comfort,shorten wear time,reduce lumbar and abdomen cold,wound pain and privacy exposure,and have high clinical value.Promote use.
2018 Vol. 25 (24): 185-187 [
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156
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188
Influence of individual and collective interventions on quality of life in patients accepted with maintenance hemodialysis
XU Qin-xiang
Objective
To study the influence of individual and collective interventions on the quality of life in hemodialysis maintenance (MHD)patients.
Methods
A total of 330 MHD patients who were admitted to our hospital from February to May in 2017 were randomly divided into 3 groups,110 cases in each group.In control groupⅠ,routine nursing was used,in control groupⅡ,individualized nursing intervention was applied,and in observation group,collective nursing intervention was adopted.The Concise Health Questionnaire(SF-36)on quality of life,KDQOL-SFTM scale,and changes of quality of life before and after intervention were compared.
Results
Before nursing,there was no significant difference in SF-36 or KDQOL-SFTM scoring among the three groups(P＞0.05）.After nursing,SF-36 and KDQOL-SFTM scoring in the observation and control groupⅡ were higher compared with those in control groupⅠ.What′s more,the scores of SF-36 and KDQOL-SFTM in the observation group were higher than those in the contro1 groupⅡ,which were displayed statistical significance between inter-group comparisons,the differences were statistically significant(P<0.05）.
Conclusion
The individual or collective intervention has a significant clinical effect on the quality of life in MHD patients,and can effectively improve their quality of life,which is worthy of clinical promotion.
2018 Vol. 25 (24): 188-190 [
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173
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191
Effect of application of Oxytocin and Doula delivery analgesia instrument in parturients with uterine atony
HE Li-li;SHI Chun-lan;YU Hong-lan
Objective
To explore the effect of application of Oxytocin and Doula delivery analgesia instrument on uterine atony in parturients.
Methods
Altogether 60 cases of parturients with uterine atony who were hospitalized in our hospital from June 2015 to June 2016 were selected and randomly divided into the routine group,the control group and the observation group,20 cases in each group.The general nursing method was used in the routine group,the control group was treated with Oxytocin;while,the observation group was given Doula delivery analgesia instrument based on the routine group and control group.The total treatment effect,the incidence of complications,the natural delivery rate and the satisfaction degree of the parturient were compared among the three groups.
Results
The total treatment effective rate of the observation group was significantly better than that of the routine group and the control group,the differences were statistically significant(P＜0.05）,and the incidence of complications of the control group and the routine group was higher than that of the observation group,the differences were statistically significant(P＜0.05）,and the natural delivery rate of the observation group was significantly higher than that of the routine group,the differences were statistically significant(P＜0.05）.The satisfaction degree of the observation groups was higher than that of the routine group and the control group,the differences were statistically significant(P＜0.05）.
Conclusion
Combination of application of Oxytocin and Doula labor analgesia achieves satisfactory effect not only in effective reduction of the incidence of complications and improvement of the natural delivery rate,but also in improved maternal satisfaction degree,which is worthy of further popularization and application.
2018 Vol. 25 (24): 191-193 [
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208
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194
Effect of procedural nursing on nursing quality and postoperative recovery of patients with ectopic pregnancy undergoing laparoscopic surgery
LI Yan-juan;LONGCai-ting;XU Min-hua;LIN Zhi-ying
Objective
To explore the effect of procedural nursing on the nursing quality and operation effect of patients with ectopic pregnancy undergoing laparoscopic surgery.
Methods
Altogether 100 cases of ectopic pregnancy who underwent laparoscopic surgery in our hospital from April 2014 to December 2015 were divided into the observation group and the control group according to the random sequential method,50 cases in each group.The control group was given the postoperative routine rehabilitation nursing.The experiment group was treated with rehabilitation nursing mode based on procedural nursing.The postoperative recovery and patients′satisfaction of the two groups administered with different nursing intervention were compared.
Results
The patients′satisfaction of experiment group was 96.00%,significantly higher than that of the control group(78.00%),with statistically significant difference(P＜0.05）.The recovery rate of experiment group at postoperative 1 week was 98.00%,significantly higher than that of the control group(80.00%),with statistically significant difference (P＜0.05）.
Conclusion
Procedural nursing can significantly improve the nursing quality and shorten the recovery time of ectopic pregnancy after laparoscopic surgery,which is worthy of clinical application.
2018 Vol. 25 (24): 194-196 [
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191
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197
Influence of comfort nursing intervention on pain and negative emotion in patients with acute pancreatitis
ZHU Hong-yan
Objective
To explore the influence of comfort nursing intervention on pain and negative emotion in patients with acute pancreatitis(AP).
Methods
From March 2016 to November 2017,40 patients with APin our hospital were selected as subjects.According to the order of admission,the patients were equally divided into control group and study group.In the control group,routine care was provided,and in the study group,comfort nursing was adopted.The visual analogue scale(VAS)score for pain evaluation,self-rating anxiety scale(SAS)score,and self-rating depression scale(SDS)score were compared in the two groups.
Results
After comfort nursing intervention,the VASscore in the study group was(2.47±0.65)points,lower than that of the control group(4.61±0.89)points,which was displayed a significant difference (P<0.05）.In the study group,the SASscore was(37.04±4.27)points,lower compared to that in the control group,(49.26±4.46)points,the difference was significant difference (P<0.05）.The SDSscore in the study group was(40.12±4.53)points,much lower than that in the control group (51.25±4.19)points with statistical significance (P<0.05）.
Conclusion
The timely comfort nursing intervention for patients with AP can relieve pain,and improve anxiety and depression so as to optimize the quality of care from the psychological and physiological aspects.The clinical effect is remarkable.
2018 Vol. 25 (24): 197-199 [
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177
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200
Analysis of effect of quality control circle activities on improving nursing level of urostomy
CHEN Lei; LI Wei;ZHAOLin-lin; ZHAOXin-xin
Objective
To explore the effect of quality control circle (QCC)activities on improving the nursing level of urostomy.
Methods
Altogether 60 cases of patients who underwent urostomy in our hospital from March 2016 to February 2017 were selected as the subjects of this study and randomly divided into the control group (30 cases)and the study group (30 cases).The control group was treated with routine nursing intervention;while,the study group was treated with QCC activity on the basis of the control group.The nursing management scores,patients′nursing satisfaction scores,complications and quality of life were compared between two groups of patients after relevant nursing intervention.
Results
The nursing management score and patients′nursing satisfaction scores of the study group were(90.52±8.13)score and(90.97±8.25)score,higher than those of the control group([77.87±7.50]score,[78.30±7.05]score),the differences were statistically significant(P＜0.05） The incidence of complications of the study group was 3.33%,lower than that of the control group(23.33%),the differences were statistically significant(P＜0.05） The physical functioning,psychological function,social function and material life were (89.63±7.97),(85.21±8.92),(80.25±6.66)and(88.14±7.05)score,higher than those of the control group of(70.25±6.90),(71.11±7.97),(70.97±6.87)and(71.97±6.55)score,the differences were statistically significant(P<0.05）.
Conclusion
Application of QCC activities demonstrates remarkable effectiveness in improvement of the nursing level of urostomy,which can improve the quality of nursing management and quality of life,reduce the incidence of complications and is worth popularizing in clinical practice.
2018 Vol. 25 (24): 200-202 [
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187
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203
Effect of early psychological nursing intervention on mental status of elderly patients with chronic heart failure
WANGNan-li;ZHANGYa-qiong
Objective
To explore the effect of early psychological nursing intervention on the mental state in elderly patients with chronic heart failure (CHF).
Methods
A total of 80 CHF patients in our hospital from January 2016 to January 2018 here selected.According to different hospitalization time,they were equally divided into control group and observation group,40 cases in each group.In the control group,routine nursing was used,while in the observation group,early psychological nursing intervention was adopted.The changes of psychological status before and after nursing in CHF patients in the two groups were compared.The psychological state of the patients was scored using the anxiety and depression scales,and the nursing satisfaction was compared between the two groups.
Results
Before nursing,there was no significant difference in psychological scores between the two groups(P＞0.05）.After nursing,the psychological status of the two groups were both improved,but better in the observation group,which was displayed a statistical difference after inter-group comparison,the differencewasstatistically sighificant(P<0.05）.The nursing satisfaction in the observation group was 95.00%,which was higher than that of the control group accounting for 70.00%,the difference was statistically sighificant(P<0.05）.
Conclusion
Theapplication of early nursingintervention hasapositive effect on improvingthepsychological state of elderly CHF patients,and can significantly enhance the mental stress of patients in a broad prospect.
2018 Vol. 25 (24): 203-205 [
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138
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206
Application of individual pain nursing intervention in emergency care of patients with nephrolithiasis
LI Zhi-hong
Objective
To observe the influence of individual pain nursing intervention on pain control in emergency patients with nephrolithiasis,so as to evaluate the application effect of this nursing method in patients.
Methods
80 cases patients with renal calculi admitted to Surgical Department in our hospital from January 2015 to December 2017 were selected as the research subjects.The patients were divided into the control group and the observation group according to the random number table method,40 cases in each groups.The patients in the control group were treated with routine nursing,and the patients in the observation group were treated with individual pain nursing intervention on the basis of the control group.The pain degree of 1,6 h and the satisfaction of the nursing care were compared between the two groups before and after the intervention.
Results
There was no significant difference in VASscores between the two groups before intervention(P＞0.05）,and the pain levels of 1 and 6 h two groups decreased significantly after the intervention,but all the time points of the observation group were significantly lower than those of the control group(P<0.05）.The nursing satisfaction of the observation group was 97.50%,while that of the control group was 75.00%.The difference between the two groups was statistically significant(P<0.05）.
Conclusion
The individual pain nursing pays attention to people oriented and makes the nursing work more pertinent.It can effectively improve the pain of renal calculi patients and improve the patient′s nursing satisfaction.It is worth popularizing in clinical application.
2018 Vol. 25 (24): 206-208 [
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181
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209
Analysis on effect of pre-examination triage and nursing on patients with emergency trauma
HE Yan-hong;ZHONGWen-zhu
Objective
To study the application effect of pre-examination triage and care programs in trauma patients in emergency.
Methods
All of 94 cases of emergency trauma in our hospital from October 2016 to October 2017 were selected.According to the random number table method,they were divided into the study group and the control group,47 cases in each group.The control group was given routine triage and care program,the experimental group was given pre-examination triage and care program,and comparative analysis of different groups of patients with clinical nursing failure rate and patients′clinical nursing satisfaction.
Results
The clinical nursing failure rate in the study group was 2.13%,which was lower than that in the control group (23.40%),and the difference was statistically significant(P＜0.05）.The total satisfaction clinical nursing in the study group was 95.74%,which was higher than that of the control group,and the difference was statistically significant(P＜0.05）.
Conclusion
In the clinical treatment of emergency trauma patients,the pre examination and nursing plan can provide patients with higher quality clinical nursing service,control the clinical nursing error rate effectively and achieve the expected clinical nursing effect,and the application value is more prominent.
2018 Vol. 25 (24): 209-211 [
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176
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212
Application effect of clinical nursing intervention on patients undergoing minimally invasive breast surgery during perioperative period
LIN Xiao-ting;CHENGJian-huan;ZHONGBi-hong
Objective
To investigate the value of perioperative clinical nursing intervention in patients undergoing minimally invasive breast surgery.
Methods
One hundred and sixteen patients undergoing minimally invasive breast surgery treated in our hospital from March 2014 to April 2017 were selected as study subjects.According to the convenience sampling method,they were divided into routine group and intervention group,58 cases in each group.In the routine group,routine nursing during perioperative period was used,while in the intervention group,perioperative comprehensive care was adopted.The nursing effect was observed and compared between the two groups.
Results
The numerical rating scale(NRS),self-rating anxiety scale(SAS),and self-rating depression scale(SDS)scores,hospital stay and incidences of complications in the intervention group were lower than those in the routine group(P<0.05).
Conclusion
Implementation of perioperative comprehensive nursing can improve the pain and poor mental status in patients with minimally invasive breast surgery,which is helpful to increase the success rate of surgery,reduce postoperative complications,and promote the early recovery of patients.Its clinical value is significant and worthy of application.
2018 Vol. 25 (24): 212-214 [
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169
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The role of psychological intervention in improving the postoperative curative effect of primary hyperhidrosis patients
KANG Jing-hua
Objective
To investigate the effect of psychological intervention on improving the postoperative efficacy of primary hyperhidrosis in patients.
Methods
108 patients with primary hyperhidrosis who were treated in our hospital from June 2015 to July 2017 were enrolled in this study.The patients were divided into the control group and the observation group with digital parry method,54 cases in each group.In the observation group,the patients were treated with basic nursing+psychological intervention,the control group was treated with basic nursing.Finally,the two groups of patients with hyperhidrosis postoperative efficacy and satisfaction were compared.
Results
The observation group micro wave probability(37.04%)and dry probability(57.41%)was higher than that in the control group(16.67%),and the moisture probability(5.56%)was lower than that in the control group (46.30%),there was statistically significant difference(P＜0.05）.The treatment satisfaction of observation group(98.15%)was higher than that in the control group(72.22%),and the difference was statistically significant(P＜0.05）.
Conclusion
Psychological intervention based on clinical opponents can increase clinical effect,reduced wet probability and increase dry probability.
2018 Vol. 25 (24): 215-217 [
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173
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Application of high quality care in patients with cervical erosion undergoing microwave treatment and evaluation on its satisfaction
HUANG Dong-lan;ZOU Hai-ying
Objective
To evaluate the effect of high quality nursing in the microwave treatment of patients with cervical erosion.
Methods
Seventy-nine patients with cervical erosion treated in our hospital from March 2016 to July 2017 were enrolled.They were divided into different groups according to the method of grasping balls.Conventional nursing was used in control group(n=35),and high quality nursing was adopted in observation group(n=44).The nursing satisfaction and quality of life scores were control compared between two groups.
Results
Nursing satisfaction in the observation group was 97.73%,and 82.86%in the control group.The satisfaction in the observation group was higher than that in the control group(P＜0.05）.The scores of somatic function,psychological function,material function,and social function in the observation group were(22.5±2.1)points,(22.4±1.2)points,(21.6±1.7)points,and(22.7±1.1)points accordingly,while in the control group were(21.3±1.8)points,(20.8±1.4)points,(19.9±1.8)points,and(21.2±1.4)points.The scores of these four indexes in the observation group were all higher compared to those in the control group with significant differences (P＜0.05）.
Conclusion
For patients with cervical erosion,the use of high-quality nursing as an intervention besides microwave therapy can improve patient′s care satisfaction and quality of life,and has an important application value.
2018 Vol. 25 (24): 218-220 [
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207
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