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| Clinical effect evaluation of Butylphthalide Soft Capsules plus Edaravone in the treatment of cerebral infarction |
| XIE Jiang ZHU Jing-chun |
| Department of Neurology,People′s Hospital of Shangli County in Jiangxi Province,Shangli 337009,China |
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Abstract Objective To investigate the clinical effect of Butylphthalide Soft Capsules plus Edaravone in the treatment of cerebral infarction.Methods A total of 162 patients with cerebral infarction who were admitted to our hospital from December 2015 to July 2016 were selected as subjects.They were divided into control group (n=81)and observation group (n=81)according to the random comprehensive balance method.The control group was treated with Edaravone,while in the observation group,Butylphthalide Soft Capsules was added on the basis of the control group.The efficacy of drug use in two groups was compared.Results There was no significant difference between two groups before treatment in indicators (P>0.05).The limb function scores (Fugl-Meyer),daily living ability scores (Barthel index),and montreal cognitive assessment(MOCA)scores in two groups after treatment were higher than those before treatment,NIH stroke scale(NIHSS)scores after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).Fugl-Meyer scores,Barthel index and MOCA scores after treatment in the observation group([92.6±0.9],[82.0±1.4],[23.0±0.6]points)were higher than those in the control group([84.6±0.6],[72.9±2.0],[20.2±1.0]points),NIHSSscores after treatment in the observation group ([11.1±0.9]points)were lower than those in the control group([20.4±1.2]points),and the differences were statistically significant(P<0.05).The total effective rate of the treatment in the observation group was 95.06%,which was significantly higher than that in the control group accounting for 81.48%,and the difference was statistically significant(P<0.05).There was no significant difference in scores of life quality between two groups before treatment(P>0.05).Scores of life quality after treatment in two groups were higher than those before treatment,and the differences were statistically significant(P<0.05).Scores of life quality after treatment in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion For patients with cerebral infarction,on the basis of Edaravone treatment,combination of Butylphthalide Soft Capsules can obtain a remarkable effect by improving patients′neurological,cognitive,and motor function as well as the quality of life,and enhance patients′activity of daily living,which is worthy of further exploration in the clinic.
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