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Quick Search     Adv Search 2017 Vol. 24, No. 9 Published: 2017-03-28   4 Effect of siRNA silencing FOXF2 on invitro metastasis of human cervical carcinoma SiHa cells LIU Li-min;SHI Wen-juan;HE Fang;WU Xue-mei Objective To explore the effect of siRNA silencing FOXF2 on invitro metastasis of human cervical carcinoma SiHa cells and its mechanism.Methods The expression of FOXF2 mRNA and protein in SiHa-siRNA-FOXF2 cells and negative control cells were detected by RT-PCR and Western blot respectively.The migration and invasion ability of cells were detected by wound-healing assay and Transwell assay before and after siRNA-FOXF2 transfection.CCK8 was used to detect the proliferation of cells before and after siRNA-FOXF2 transfection.Results The expression of FOXF2 mRNA and protein in siRNA-FOXF2 transfected group was significantly decreased after FOXF2 knockout in SiHa cells by RT-PCR and WB detection;the invasion and migration were enhanced by wound-healing assay and transwell assay.After transfection of siRNA-FOXF2 into cervical cancer SiHa cell lines,the capability of cell proliferation was significantly enhanced(P<0.01).Conclusion siRNA-FOXF2 can promote the invitro metastasis and proliferation of SiHa cells,and promote the development of cervical cancer. 2017 Vol. 24 (9): 4-07 [Abstract] ( 173 ) HTML (51 KB)  PDF  (0 KB)  ( 36 ) 8 The influence of p38MAPK signal pathway regulateing expression of IL-6,HIF-1α and VEGF on the chronic rhinosinusitis FAN Jun;ZHAO Chang-min;LIU Zhao-fang;HU Wen-ting;PANG Ming-jie Objective To observe the difference of the degree of expression of p38 mitogen-activated protein kinase (p38 MAPK)in chronic rhinosinusitis(CRS)without nasal polyps(CRSsNP),CRS with nasal polyps (CRSwNP)and normal uncinate process,and the expression of interleukin-6 (IL-6),hypoxia-inducible factor 1 alpha (HIF-1α)and vascular endothelial growth factors(VEGF)in different types of CRS.And explore the possible mechanism of p38MAPK signaling pathway in CRS.Methods Patients with nasal endoscopic surgery in department of otolaryngology of Qingdao Municipal Hospital were selected from July 2015 to July 2016 in Qingdao municipal hospital otolaryngology.32 cases of patients with CRSsNP sinus tissue,30 cases of CRSwNP patients with nasal polyps and 24 cases of with normal uncinate mucosa were selected for the study.The protein expression of p38 MAPK in three groups was detected by Western blotting.And the mRNA expression levels of IL-6,HIF-1α and VEGF in three groups were detected by reverse transcriptase-polymerase chain reaction (RT-PCR). Results The expression of p38MAPK in CRSsNP and CRSwNP was higher than that in normal mucosa,but there was no sig nificant difference between the twogroups(P=0.143).The expression of IL-6 in CRSsNP and CRSwNP was higher than that in normal mucosa,but there was no significant difference between two groups (P=0.082).The expression of HIF-1α and VEGF in CRSwNP was significantly higher than that in normal tissues (P<0.05).While there was no significant difference in the expression of VEGF in CRSsNP and normal tissues(P=0.075).Conclusion p38 MAPK in CRSsNP and CRSwNP shows a different correlation with inflammatory factor IL-6,and the advantage of the expression of IL-6 in CRSsNP and CRSwNP is different,and the expression of IL-6 in CRSsNP is more significant and more closely related.HIF-1a and VEGF are also highly expressed in CRSwNP tissues,which may be related to the production of polyps. 2017 Vol. 24 (9): 8-11转22 [Abstract] ( 176 ) HTML (49 KB)  PDF  (0 KB)  ( 34 ) 12 Experimental study of estrogen antagonist combined with celecoxib in the treatment of rabbit with knee joint traumatic myositis ossificans HAN Feng;LU Cheng-hua;YI Li;JIANG Hong Objective To investigate preventive effect of estrogen antagonist Tamoxifen combined with Celecoxib in the rabbit with knee joint traumatic myositis ossificans.Methods 30 rabbits were randomly divided into group A,B and C, traumatic myositis ossificans model of knee joint were make with knee joint fixed after strong passive stretch and violent massage,and rabits in group A were given the normal saline B were treated with Tamoxifen and Celecoxib and the group C were treated with Tamoxifen and Celecoxib,rabits in the group,all rabits were treated for 9 weeks.The swelling degree of knee joint were compared among three groups at 1,5,9 weeks after making model,degree of myositis ossificans were compared among three groups at 5,9 weeks after making model.Results Circumference of knee joint at 1 week after making model than was larger than before making model among three groups (group A:t=7.14,P=0.000;group B:t= 5.29,P=0.000;group C:t=4.86,P=0.001),and the group A was larger than that of the group C (t=3.96,P=0.002)and group B(t=3.57,P=0.003),and the group C was less than that of the group B(t=2.48,P=0.007);circumference of knee joint 5 week after making model was less than 1 week after making model among three groups(group A:t=3.26,P=0.005;group B:t= 2.94,P=0.004;group C:t=2.58,P=0.004),circumference of knee joint in group A was larger than that in the group B (t= 5.19,P=0.000)and group C(t=6.10,P=0.000),and the group B was larger than that in group C(t=2.84,P=0.003);9 week after making model,circumferences of knee joint of group A and group B were larger than those at 5 weeks after making model(group A:t=1.96,P=0.010;group B:t=1.84,P=0.013),and the group C was less than that at 5 weeks after making model(t=2.29,P=0.008),circumference of knee joint of the group A was larger than that in the group C(t=3.82,P=0.001) and group B(t=3.14,P=0.002),and group C was less than that in the group B(t=4.29,P=0.000).Degree of myositis ossificans at 5,and 9 week after making model was different among three groups(5 weeks:H=7.29,P=0.001,9 weeks:H=17.16, P=0.000),and degree of myositis ossificans in group B and group C was lower than that in the group A at different time point(group B,5 weeks:U=4.26,P=0.004,9 weeks:U=8.46,P=0.000;group C,5 weeks:U=5.14,P=0.002,9 weeks:U=9.17,P=0.000),and group C was lower than that in the group B(5 weeks:U=4.26,P=0.004,9 weeks:U=4.89,P=0.003).Conclusion Estrogen antagonist Amoxifen combined with Celecoxib can effectivly control the progress of myositis ossificans,and improve effect of prevention. 2017 Vol. 24 (9): 12-14 [Abstract] ( 151 ) HTML (38 KB)  PDF  (0 KB)  ( 38 ) 15 The research progress of preventive efficacy of calcium intake for osteoporotic fracture GAO Chun-lin;JIANG Hong;TANG Jia-guang;HOU Shu-xun Calcium and Vitamin D have widely been recommended for older individuals as a basic therapy to prevent osteoporosis and subsequent fractures,but the effect is not very ideal and research conclusion is a lack of consistency. Some studies support the preventive effect of calcium intake for osteoporosis and fractures,but others may not.And it is not yet clear which benefits more,Calcium with or without vitamin D,from dietary or supplementations,with low or high dose.This review analyzes the high grade evidence,such as cohort studies,randomized controlled studies and Meta analysis from recently published literature,to analyse the efficacy of calcium intake,and present some suggestion for the public to make suitable calcium regime. 2017 Vol. 24 (9): 15-17 [Abstract] ( 162 ) HTML (37 KB)  PDF  (0 KB)  ( 40 ) 18 The function and mechanism of TNIP1 in human autoimmune disease GU Huan;WANG Wen-xue;LI Xiao-lan;LI Mei-zhang TNFAIP-interacting protein 1 (TNIP1)also called A20-binding inhibitor of NF-κB ctivation(ABIN1),and TNIP1 can combine and inhibit transmembrane receptors,such as TNF-αR,EGFR and TOLL sample receptor,and it can combine and inhibit nuclear receptor,such as PPAR and RAR.Current studies mainly focus on function and molecular pathways of TNIP1 on inflammation and autoimmune diseases,such as psoriasis vulgaris,rheumatoid arthritis and systemic lupus erythematosus.This view summarized recent studies following the function and mechanism of TNIP1 in human autoimmune diseases. 2017 Vol. 24 (9): 18-22 [Abstract] ( 164 ) HTML (55 KB)  PDF  (0 KB)  ( 40 ) 23 The related application research of hypersensitive C-reactive protein in cerebral ischemic stroke CHEN Hong;LI Qin Inflammation reaction takes part in occurrence and development of cerebral ischemic stroke.As one marker of acute inflammation reaction,hypersensitive C-reactive protein plays an important role in condition and prognosis evaluation of acute cerebral ischemic stroke patients.In acute stage of cerebral ischemic stroke,the level of hypersensitive C-reactive protein increases significantly,whichis closely related to risk factors of acute cerebral infarction,and it has a positive correlation between the severity of condition.Compared with the traditional cardiovascular disease risk factors, hypersensitive C-reactive protein in cerebrovascular disease has better predictive value.By means of intervening atherosclerosis formation and lowering hypersensitive C-reactive protein serum concentration may develop new study direction for prevention and treatment in cerebralischemic stroke. 2017 Vol. 24 (9): 23-26 [Abstract] ( 154 ) HTML (51 KB)  PDF  (0 KB)  ( 36 ) 27 Effects of Cetirizine Hydrochloride reduction therapy combined with Compound Glycyrrhizin on serum IgE and IL-6 levels in patients with chronic urticaria XU Guan-hui;HUANG Xiu-mei;CHEN Wei-zhong Objective To investigate the effect of Cetirizine Hydrochloride reduction therapy combined with Compound Glycyrrhizin on serum IgE and IL-6 levels in patients with chronic urticaria.Methods A total of 100 patients with chronic urticaria admitted to Nanhai District the Seventh People′s Hospital of Foshan City from September 2015 to December 2016 were selected as study object and divided into combined group and single group according to the random number table method,50 cases in each group,30 healthy subjects were selected as control group.Patients in the combined group were treated with Cetirizine Hydrochloride reduction therapy combined with Compound Glycyrrhizin,and patients in the single group were treated with Cetirizine Hydrochloride reduction therapy,patients of two groups were treated continuously for 6 weeks.Curative effect between the combined group and the single group,changes of serum IgE and IL-6 levels before and after treatment among three groups were compared.Results The total effective rate of the combined group was 98.0%,which was significantly higher than that of the single group (86.0%),and the difference was statistically significant(P<0.05).The level of IgE before treatment in the combined group and the single group was significantly higher than that in the control group(P<0.05);after treatment,the levels of IgE in the combined group and the single group was significantly lower,but which was still significantly higher than that in the control group,the level of IgE in the combined group was significantly better than that of the single group(P<0.05);compared with the control group, the levels of IL-6 before and after treatment had no significant different in the combined group and the single group (P>0.05).Conclusion Cetirizine Hydrochloride reduction therapy combined with Compound Glycyrrhizin in the treatment of chronic urticaria can significantly improve the curative effect and the serum IgE level,but there is no significant effect on serum IL-6 level,it is suggested that the level of IL-6 may not be associated with chronic urticaria. 2017 Vol. 24 (9): 27-29 [Abstract] ( 155 ) HTML (39 KB)  PDF  (0 KB)  ( 31 ) 30 Evaluation of recent curative effect,traumatic degree and complication of complete mesocolic excision in treating colon cancer SHI Yi-jun;SONG Yao-ming;ZENG Huai-zhen Objective To study the recent curative effect,traumatic degree and complication of complete mesocolic excision(CME)in treating colon cancer.Methods 30 cases of colon cancer patients received CME in our hospital from January 2012 to December 2016 were selected as CME group,30 cases of colon cancer patients who received traditional radical surgery were selected as control group.Then perioperative condition,number of lymph node dissection,postoperative complications were observed between two groups,before surgery and the very day after the operation,serum were collected and the content of inflammatory mediators in before and 1,3,5,7 d after operation were measured between two group.Results The operation time,intraoperative blood loss,postoperative drainage,postoperative exhaust time,time in bed,wound infection,anastomotic leakage,urinary retention and intestinal obstruction between two groups were compared, and the difference was not statistically significant(P>0.05);total number of lymph node dissection and number of lymph node dissection of phase B and phase C in the CME group was significantly more than that in the control group(P<0.05), number of lymph node dissection of phase A compared with the control group,the difference was not statistically significant(P>0.05).Before operation,there wasnostatisticallysignificantdifferenceinserumCRPcontentbetweentwogroups(P> 0.05);1,3,5,7 d after operation,serum CRP content of two groups were significantly higher than that before operation,and the difference was statistically significant(P<0.05);1,3,5,7 d after operation,there was no statistically significant difference in serum CRP content between two groups(P>0.05).There was no significant difference in the incidence of complications between two groups(P<0.05).Conclusion CME in the treatment of colon cancer can improve the efficiency of lymph node dissection,avoid the lesion extrusion caused by surgery,and does not increase the surgical trauma and postoperative complications. 2017 Vol. 24 (9): 30-32转52 [Abstract] ( 155 ) HTML (43 KB)  PDF  (0 KB)  ( 42 ) 33 Application effect of respiratory humidification treatment apparatus in weaning patients with ICU mechanical ventilation ZHANG Peng;WEI Peng Objective To observe the application effect of respiratory humidification treatment apparatus in weaning patients after mechanical ventilation.Methods From January 2014 to March 2015,46 patients given conventional double nasal mask dual channel oxygen inhalation after ICU mechanical ventilation were selected as control group,32 patients using AIRVO2 type respiratory humidification treatment apparatus from March 2015 to November 2016 were selected as treatment group after ICU mechanical ventilation.Sputum viscosity 6,12,24,48,72 h after weaning,the incidence of postoperative pulmonary infection,the blood gas index 6,12,24,48,72 h after weaning,secondary mechanical ventilation rate and bleeding rate of airway were compared between two groups.Results In the treatment group from weaning 6 h, patients withⅠ degree of sputum viscosity was significantly more than that in the control group,the patients withⅡdegree of sputum viscosity was less than that in the control group,nobody withⅢ degree of sputum viscosity;the patients in the control group hadⅢdegree of sputum viscosity from weaning 24 h,and with the increase of weaning time, the number of cases was gradually increased.At the same time point humidification effect in the treatment group was obviously superior to that in the control group,and the difference was statistically significant(P<0.05).72 h after weaning,the incidence of pulmonary infection in the treatment group was 3.13%,in the control group of 9.38%;1 week after weaning,the incidence of pulmonary infection in the treatment group was 9.38%,lower than that in the control group of 25.00%,and the difference was statistically significant(P<0.05).6,12,24,48,72 h after weaning,SpO2,PaCO2,PaO2in the treatment group was better than that in the control group,and the difference was statistically significant(P<0.05).1 week after weaning,nobody in the treatment group appeard secondary mechanical ventilation,3 patients in the control group with mechanical ventilation,mechanical ventilation rate in the control group was 9.38%,and the difference was statisti-cally significant(P<0.05).Bleeding rate of airway after weaning in the treatment group was 6.25%,in the control group of 71.88%,there was statistically significant difference(P<0.05).Conclusion The use of respiratory humidification treatment apparatus after mechanical ventilation is better than the current conventional dual route oxygen inhalation,can reduce the incidence of adverse events,and it is worth promoting in clinic. 2017 Vol. 24 (9): 33-36 [Abstract] ( 174 ) HTML (46 KB)  PDF  (0 KB)  ( 31 ) 37 The clinical value of procalcitonin monitoring antibacterial therapy for critically ill patients in ICU ZHENG Wei;LU Wen Objective To investigate the guidance value of procalcitonin (PCT)in the detection of antibacterial agents usage for critically ill infected patients in ICU.Methods 88 cases of critically ill patients in ICU admitted to our hospital from January to December 2016 were selected as study object and divided into routine group and PCT group according to the order of admission with 44 patients respectively in each group,patients in the routine group were treated with antibiotics,and patients in the PCT group were treated with antibiotic by the guidance of PCT content.Each index level before and after treatment,treatment and prognosis in two groups were observed.Results There was no difference in the levels of WBC,CRP and PCT before treatment between two groups(P＞0.05);after treatment,there was still no difference in WBC,CRP and PCT levels between two groups(P＞0.05).The antibiotic use time,ICU hospitalization time and costs of the PCT group was less than that of the routine group(P<0.05).The survival rate and mortality rate of the PCT group was 95.45%and 4.55%respectively,which was significantly higher than 86.36%and 13.64%in the routine group (P＜0.05).Conclusion PCT can play a good role in guiding the treatment of ICU infection in critically ill patients,can significantly reduce the amount of the antibiotics and time,improve the survival rate,which is worthy of clinical promotion and application. 2017 Vol. 24 (9): 37-39 [Abstract] ( 153 ) HTML (39 KB)  PDF  (0 KB)  ( 29 ) 40 Analysis of early respirator instead of hyperbaric oxygen therapy in patients with acute severe carbon monoxide poisoning XIAO Shi-hui Objective To investigate the clinical effect of early respirator instead of hyperbaric oxygen therapy in patients with acute severe carbon monoxide poisoning.Methods 50 patients with acute severe carbon monoxide poisoning who were treated in our hospital from September 2014 to December 2016 were selected as study object and divided into control group and observation group according to the method of odd and even random grouping,25 cases in each group. Patients in the control group were treated with conventional therapy,patients in the observation group were given the replacement therapy of hyperbaric oxygen by early ventilator.The death probability,consciousness recovery time,hospital stay,the incidence of delayed encephalopathy and sequelae between two groups were compared.Results There was no significant difference in death probability between two groups(P>0.05).The consciousnes recovery time and hospitalization time in the observation group was shorter than that in the control group,and the incidence of delayed encephalopathy and the incidence of sequelae was significantly lower than that of the control group (P<0.05).Conclusion On patients with acute severe carbon monoxide poisoning,the effect of early respirator instead of hyperbaric oxygen therapy is significant,which is worth popularizing in clinic. 2017 Vol. 24 (9): 40-42 [Abstract] ( 164 ) HTML (37 KB)  PDF  (0 KB)  ( 31 ) 43 Clinical study of continuous intracranial pressure and cerebral perfusion pressure monitoring in patients with severe craniocerebral injury LIN Li-chao;YANG Jian-xiong;YE Zhi-qi;HUANG Jian-bin;ZHANG Jian-wei Objective To investigate the clinical effect of continuous intracranial pressure (ICP)and cerebral perfusion pressure (CPP)monitoring in patients with severe craniocerebral injury,and to provide guidance for clinical practice. Methods 80 patients with severe craniocerebral injury admited to hospital within 72 h after injury were selected as study object by random envelope extraction in our hospital from October 2015 to December 2016,they were randomly divided into control group and experimental group,40 cases in each group.Patients in the control group were not given monitoring,patients in the experimental group were given continuous ICP and CPP monitoring,in which 16 cases were admitted within 24 h after injury,24 cases were admitted within 24-72 h after injury,and patients in the experimental group were divided into group A (CPP≥9.33 kPa)and group B (CPP<9.33 kPa)according to CPP level of the admission,the clinical effects of ICP and CPP monitoring were compared.Results The good recovery rate of patients in the experimental group was 62.50%,significantly higher than that in the control group (40.00%),severe disability rate (5.00%)was significantly lower than that in the control group(20.00%),the mortality rate(7.50%)was significantly lower than that in the control group(25.00%),the clinical effect of the experimental group was better than that of the control group, and the difference was statistically significant(P<0.05).Within 24 h after injury,MABP,PaO2in group A was significantly higher than that in group B (P<0.05),there was no obvious difference in other indexes(P>0.05);within 24-72 h after injury,ICP in group A was significantly lower than that in group B(P<0.05),there was no obvious difference in other indexes(P>0.05).Conclusion The implementation of continuous ICP and CPP monitoring is helpful to improve the prognosis of patients with severe craniocerebral injury,at the same time reasonable intervention measures should be implemented combined with the actual situation of patients. 2017 Vol. 24 (9): 43-45 [Abstract] ( 176 ) HTML (40 KB)  PDF  (0 KB)  ( 35 ) 46 Clinical characteristics analysis of 67 cases pulmonary tuberculosis complicated with lung cancer REN Li-juan;LIU Ya-li Objective To analyze the clinical characteristics of pulmonary tuberculosis patients complicated with lung cancer,in order to provide reference for early diagnosis of pulmonary tuberculosis complicated with lung cancer.Methods 67 cases of pulmonary tuberculosis patients complicated with lung cancer in Inner Mongolia Autonomy No.4 Hospital from January 2011 to May 2016 were selected as observation group,60 patients with tuberculosis admitted in the same period was selected as control group.The clinical characteristics,pulmonary CT imaging findings,tumor markers of two groups were retrospectively analyzed.Results The occurrence of irritating dry cough,progressive dyspnea,voice hoarse,fatigue and night sweats,chest pain clinical manifestations had no significant difference between two groups(P> 0.05);the occurrence of haemoptysis in the control group was significantly higher than that in the observation group(P＜0.05).The incidence of bilateral upper lobe lesions showed by lung CT in the control group was significantly higher than that in the observation group (P＜0.05).The expression of CEA,NSE,CYFRA21-1 of the observation group was significantly higher than that of the control group(P<0.05);the expression of CA125 of the control group was obviously higher than that of the observation group (P<0.05).Conclusion There is no significant difference in clinical manifestation between pulmonary tuberculosis patients complicated with lung cancer and pure tuberculosis patients.Fully grasping the pulmonary CT imaging findings and tumor markers of pulmonary tuberculosis patients complicated with lung cancer is conducive to improve early diagnosis and treatment. 2017 Vol. 24 (9): 46-48 [Abstract] ( 150 ) HTML (37 KB)  PDF  (0 KB)  ( 35 ) 49 Application effect of nerve mobilization on the lumbar disc herniation after collagenase chemonucleolysis LING Chang-quan;CHE Ge-fang;LI Hai-lan Objective To investigate the effect of nerve mobilization on the lumbar disc herniation after collagenase chemonucleolysis,in order to improve the curative effect.Methods From February 2015 to January 2017,60 cases of lumbar disc herniation with collagenase chemonucleolysis were selected as the research object and divided into control group and observation group according to the random number table method,30 cases in each group.Patients in the control group received conventional treatment methods after collagenase chemonucleolysis,patients in the observation group received nerve mobilization treatment,the effects,blood related indexes before and after treatment,changes of visual analogue score(VAS),Japan Association for Department of Orthopedics lumbar disease assessment form(JOA)score,sciatic nerve angle and lumbar nerve root angle before and after treatment were compared between two groups.Results The effective of the observation group was significantly betterer than that of the control group,and the difference was statistically significant(P<0.01).The level of IL-1,TNF-α,TXB2 after treatment in the observation group was significantly lower than that before treatment,and the difference was statistically significant(P<0.05);there was no statistically significant difference in the level of IL-1,TNF-α,TXB2 before and after treatment in the control group(P>0.05);IL-1,TNF-α,TXB2 after treatment in the observation group was decreased significantly than that in the control group,and the difference was statistically significant(P<0.05).VAS score after treatment in two groups was decreased significantly than that before treatment,JOA score,sciatic nerve angle,lumbar nerve root angle recovery after treatment was significantly increased than that before treatment,and the difference was statistically significant(P<0.05);the above indexes in the observation group was improved more significantly than that in the control group,and the difference was statistically significant(P< 0.05).Conclusion Nerve mobilization can improve the clinical symptoms of lumbar disc herniation after collagenase chemonucleolysis,and improve the curative effect. 2017 Vol. 24 (9): 49-52 [Abstract] ( 157 ) HTML (42 KB)  PDF  (0 KB)  ( 35 ) 53 Comparison of clinical effect of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion in the treatment of lumbar spondylolisthesis CHEN Run-jiang Objective To compare the clinical effects of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion in the treatment of lumbar spondylolisthesis.Methods 186 cases of lumbar spondylolisthesis treated in our hospital from January 2013 to December 2015 were selected as the research object and divided into control group (n=90)and observation group (n=96)according to the different treatment methods.The control group received posterior lumbar interbody fusion,and the observation group received transforaminal lumbar interbody fusion.The operation time, intraoperative blood loss,clinical efficacy,bone graft fusion rate and complications between two groups were compared. Results The operative time and intraoperative blood loss of the observation group was significantly less than that of the control group[(129.85±19.97)min vs.(168.46±18.92)min;(252.59±30.18)ml vs.(346.63±38.66)ml,P<0.01].The clinical symptoms improved rate of the observation group was significantly higher than that of the control group [(91.56± 7.69)%vs.(83.78±5.62)%,P<0.01].There was no significant difference in the fusion rate of bone graft(91.11%vs. 93.75%)and the complication rate(12.22%vs.7.29%)between the control group and the observation group(P＞0.05). Conclusion The posterior lumbar interbody fusion and transforaminal lumbar interbody fusion are effective treatment method for lumbar spondylolisthesis,and the operation time,intraoperative blood loss and clinical symptom improvement rate of the later are better than those of the former. 2017 Vol. 24 (9): 53-55 [Abstract] ( 156 ) HTML (36 KB)  PDF  (0 KB)  ( 34 ) 56 The therapeutic effect of interlocking intramedullary nailing via suprapatellar approach in the treatment of tibial fracture FU Sheng-pei Objective To analyze the therapeutic effect of interlocking intramedullary nailing via suprapatellar approach in the treatment of tibial fracture.Methods 98 patients with tibial fracture who were treated in our hospital from December 2013 to June 2015 were chosen and randomly divided into control group and observation group.The control group was treated with traditional interlocking intramedullary nailing via subpatellar approach,the observation group was treated with interlocking intramedullary nailing via suprapatellar approach.Operation time,intraoperative blood loss,hospital stay,fracture healing time,therapeutic effect,HSS scores and Lysholm scores 9 months after operation were compared between two groups.Results There was no significant difference in operation time,intraoperative blood loss,hospital stay, fracture healing time between two groups（P>0.05).The excellent and good rate and degree of knee pain in the observation group was significantly better than that in the control group (P<0.05).The HSS scores and Lysholm scores 9 months after operation in the observation group was significantly better than that in the control group,and the difference was statistically significant (P<0.01).Conclusion Interlocking intramedullary nailing via suprapatellar approach is an effective treatment for tibial fracture,which has better therapeutic effect and less knee pain risks,joint function recover is well, which deserves a further application in clinical treatment. 2017 Vol. 24 (9): 56-58 [Abstract] ( 156 ) HTML (38 KB)  PDF  (0 KB)  ( 43 ) 59 Clinical effects of suture anchor tenodesis in repairing acute closed distal achilles tendon injuries ZHU Yu-hui;LYU You;LIANG Xian-dan;DU Wei;WANG Hong-jia Objective To explore the effect of suture anchors in the treatment of acute closed distal acholles tendon injuries.Methods Clinical date of 25 cases treated with suture anchor tenodesis in our hospital from January 2012 to March 2015 were retrospectively analyzed.The operation was performed,with the suture anchors to reconstruct the achilles tendon insertion,and the Krachow technique was used to suture the achilles tendon.The situation of the wound healing,heel pain,and achilles tendon re-rupture were observed and analyzed during the follow-up.According to passive range of motion of bilateral ankle joint,the American orthopaediac foot and ankle society (AOFAS)score was wsed to assesse the function of ankle joint 18 months after operation.Results All patients were followed up for 16-36 months, the wound healed well,without complication such as infection,skin necrosis.There was no significant difference in mean passive plantar flexion between injured ankles and contralateral ankles 18 months after operation [(42.20±3.33)°vs. (41.00±4.63)°,P>0.05],whereas dorsiflexion range was less than the contralateral side[(15.68±4.10)°vs.(21.12±3.01)°,P< 0.05].AOFAS rating 80-100 points,the average was (91.5±4.6)points.26 cases of excellent,4 cases of good.Conclusion The short-term effect of sutre anchers repairing the acute closed distal achilles tendon injuries is good. 2017 Vol. 24 (9): 59-61 [Abstract] ( 143 ) HTML (36 KB)  PDF  (0 KB)  ( 37 ) 62 Analysis of effect of proximal anti-rotary intramedullary nail in the treatment of elderly patient with femoral intertrochanteric fracture CHENG Wei-feng;WANG Xiao-shan;LIAO Bang-qiang Objective To explore the clinical effect of proximal anti-rotary intramedullary nail in the treatment of elderly patient with femoral intertrochanteric fracture.Methods 87 elderly patients with femoral intertrochanteric fracture treated in our hospital from January 2015 to April 2016 were selected and divided into the observation group(47 cases) and the control group(40 cases)according to different operation methods.The observation group was treated with proximal anti-rotary intramedullary nail,the control group was treated with dynamic hip screw.The clinical effect and complications in the two groups were compared.Results The Harris score in the observation group was higher than that in the control group, the hospitalization time in the observation group was shorter than that in the control group,with significant difference(P＜0.05).The excellent and good rate of the observation group was higher than that of the control group,with significant difference(P＜0.05)The incidence rate of complications in the observation group was 2.1%,which was lower than that in the control group(15.0%),with significant difference(P＜0.05).Conclusion The application of proximal anti-rotary intramedullary nail in the treatment of elderly patient with femoral intertrochanteric fracture is more effective,with higher safety. 2017 Vol. 24 (9): 62-64 [Abstract] ( 134 ) HTML (42 KB)  PDF  (0 KB)  ( 40 ) 65 Comparison of the application effects of intracavity COOK balloon and IUD after hysteroscopic adhesions separation operation LI Hong-shu Objective To compare the application effects of intracavity COOK balloon and IUD after hysteroscopic adhesions separation operation.Methods From March 2014 to March 2014,72 patients afer hysteroscopy adhesion separation operation in our hospital were selected and divided into experimental group and control group according to their wishes,with 36 cases in each group.COOK balloon was adopted in the experimental group and IUD was adopted in the control group.The preventing adhesion effect,menstrual recovery,complications and satisfaction of patient in the two groups were compared.Results The effect rate of preventing adhesion and menstruation recovery of the experimental group were significantly higher than those of the control group,the differences were statistically significant(P<0.05).The incidence of intrauterine infection,postoperative bleeding,uterine perforation and contents hernia of the experimental group were lower than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference between the satisfaction of two groups(P>0.05).Conclusion COOK balloon can effectively prevent intrauterine adhesions again,significantly alleviate the symptoms,rapidly return the normal menstruation,has fewer complications and high security,it is worthy to promoting. 2017 Vol. 24 (9): 65-67 [Abstract] ( 154 ) HTML (38 KB)  PDF  (0 KB)  ( 30 ) 68 Effect of potassium Sodium Dehydroandroan drographolide Succinate combined with interferon inhalation in treatment of children with herpangina JIANG Xia Objective To probe into the clinical effects of potassium Sodium Dehydroandroan drographolide Succinate combined with interferon inhalation in treatment of children with herpangina.Methods 78 cases of children with herpangina and who accepted treatments in our hospital from May 2014 to March 2016 were selected as the research object,and were randomly divided into observation group(37 cases)and control group(39 cases)by the random digit table grouping method.Patients of the two groups were treated with conventional therapy,on the basis of conventional treatmen,the control group were treated with Ribavirin while in the observation group,on the basis of the treatment in the control group,they were treated with potassium Sodium Dehydroandroan drographolide Succinate combined with interferon inhalation.Then,the clinical effects,symptom disappearance time,rate of adverse reaction and so on of two groups were observed.Results The total effective rate of the observation group was 94.87%,which was significantly higher than that in the control group (76.92%),the difference was statistically significant(P<0.05);the salivation disappeared time, herpes disappear time,pyretolysis time,healing time in the observation group after treatment was significantly shorter than the control group respectively,the difference was statistically significant(P<0.05);the incidence of adverse reactions in the observation group after treatment was 7.69%,while in the control group was 28.21%,the difference between the two groups was statistically significant(P<0.05).Conclusion The effect of potassium Sodium Dehydroandroan drographolide Succinate combined with interferon inhalation in treatment of children with herpangina is satisfactory,which can shorten the recovery the time of symptoms and signs,promote the rehabilitation of the disease,but also with high safety,thus it is worthy to be promoted in the clinical. 2017 Vol. 24 (9): 68-70 [Abstract] ( 156 ) HTML (40 KB)  PDF  (0 KB)  ( 44 ) 71 The clinical research of Methylprednisolone combined with Tropisetron for prevention of postoperative nausea and vomiting in laparoscopic operation FANG Jian-qin;LU You-ming;YE Wei-biao;ZHENG Jian-yu;HE Jian-fang Objective To explore the effect of Methylprednisolone combined with Tropisetron for preventing postoperative nausea and vomiting(PONV)in patients with laparoscopic operation.Methods A total of 180 patients in our hospital from September 2014 to September 2016 received general anesthesia in laparoscopic surgery were retrospectively analyzed.By different processing methods before induction of anesthesia were divided into three groups,60 cases in each group.dirp A(methylprednisolone,40 mg),group B(dexamethasone,8 mg),and group C(saline,2 ml),they were given intravenouse dirp all before induction of anesthesia.At the end of operations,all the patients would be Tropisetron(5 mg)by injection.The incidence of PONV in three groups of 0,6 h and 24 h,and 24 h dirp postoperative incidence of adverse reactions were compared.Results In group A,group B and group C,postoperative 0 h the incidence of PONV respectively were 6.67%,20.00%,36.67%,postoperative 6 h the incidence of PONV respectively were 13.33%,31.67%,53.33%,postoperative 24 h the incidence of PONV respectively were 8.33%,21.67%,38.33%.there were significant difference between the three groups(P<0.05).In group A,group B and group C postoperative 24 h adverse reactions incidence respectively were 10.00%,18.33.00%,40.00%.While group A was compared with group B did not significant difference (P>0.05),group A and B were compared with group C,with significant difference(P<0.05).Conclusion It appeares to be effective of methylprednisolone combined with tropisetron in preventing PONV,which is worth further promotion in the clinical practice. 2017 Vol. 24 (9): 71-74 [Abstract] ( 155 ) HTML (45 KB)  PDF  (0 KB)  ( 40 ) 75 Pediatric neurosurgery operation management LYU Wei;XU Ling;SUN Shu-ying Objective To investigate the anesthesia of pediatric neurosurgery.Methods Anesthesia methods used in the management of 69 cases of pediatric neurosurgery from January 2013 to June 2015 were retrospectively studied.To visit before anesthesia and fasting,anesthesia induction,airway management,intraoperative monitoring,maintain anesthesia, intraoperative fluid and electrolyte management method,the prognosis of children were observed.Results 1 case after cardiac arrest in the successful rescue,prognosis was good;1 case of postoperative death,the procedures of other cases were successfully carried out.Conclusion The risk of pediatric neurosurgery anesthesia is big,Pediatric neurosurgery anesthesia risk big,the anesthesia from preoperative assessment,intraoperative airway,circulation,brain protection,temperature control and disease itself various aspects accurate judgment,timely treatment,to reduce the incidence of perioperative complications and mortality is important. 2017 Vol. 24 (9): 75-77转81 [Abstract] ( 181 ) HTML (41 KB)  PDF  (0 KB)  ( 30 ) 78 Research of application of induction of anesthesia with Sevoflurane and Ketamine anesthesia induction for children with systemic YIN Jun;WU Shi-min Objective To explore the application effects of induction of anesthesia with Sevoflurane and Ketamine anesthesia induction for children with systemic.Methods 82 cases of children with indirect inguinal hernia and who underwent the systemic general anesthesia operation in our hospital from January 2014 to January 2016 were collected,and they were randomly divided by the computer.In the control group of 41 children were underewent induction of anesthesia of Ketamine,while the observation group of 41 cases were underwent the induction of anesthesia with Sevoflurane. Then,the change level of heart rate(HR),mean arterial pressure(MAP),oxygen saturation(SpO2)of two groups were monitored,the anesthetic induction time,crying time,operation time and postoperative recovery time were compared between the two groups,and the occurrence of restlessness of two groups was statistically analyzed.Results There was no significant difference in SpO2level between the two groups before and after operation (P>0.05);the levels of HR and MAP for T1,T2,T3,T4in the observation group were lower than those in the control group(P<0.05);the operation time of the two groups were not obvious,but the anesthesia induction time,crying time and postoperative recovery time in the observation group were (154.92±10.08),(65.24±6.01)s,(28.31±3.29)min,which were shorter than those in control group (226.45± 16.54),(98.30±8.56)s and(62.18±5.73)min(P<0.05);the incidence of restlessness during recovery period in the observation group was 4.88%,which was lower than that in the control group of 17.07%(P<0.05).Conclusion The induction of anesthesia with sevoflurane in pediatric with systemic general anesthesia which it has the characteristics of rapid onset and rapid postoperative recovery.At the same time,it has little effect on respiratory cycle. 2017 Vol. 24 (9): 78-81 [Abstract] ( 144 ) HTML (42 KB)  PDF  (0 KB)  ( 35 ) 82 Application of the retreat needle core method in MSCT guided percutaneous transthoracic needle biopsy in small nodules(15 mm≤diameter≤30 mm) operation of lung hilar region CUI Hua-zi;CHEN Ai-lin;ZHANG Shou-lin Objective To explore value of the retreat needle core method in MSCT guided percutaneous transthoracic needle biopsy in small nodules(15 mm≤diameter≤30 mm)operation of lung hilar region.Methods 43 lung hilar nodules(15 mm≤diameter≤30 mm)patients from January 2010 to May 2016 in our hospital were selected as study objects.All of the patients were not satisfied with pathological results by 1-2 bronchoscopy.All patients were divided into group A (16 cases)and group B (27 cases).Group A was used multiple puncture to get samples and group B was used retreat needle core puncture.Two groups of patients were treated with self-made surface positioning grid.MSCT enhanced scanning MPR image simulation puncture was used to find a safe biopsy path;BARD semi-automatic biopsy gun and 18 G×200 mm biopsy needle were used to collect two specimens and conduct pathological examination.The operation time,the success rate of puncture,diagnostic positive rate and the incidence rate of complication in the two groups were statistically analyzed.Results The average operation time,complication rate,the success rate of puncture and diagnostic positive rate in group A were respectively (58.80±5.63)min,50.00%,93.75%and 87.75%,which were respectively (33.42±5.17)min,18.51%,100.00%and 96.29%in group B.There was significant difference in the operation time and the incidence rate of complication between the two methods(P＜0.05).Conclusion The retreat needle core method in MSCT guided percutaneous transthoracic needle biopsy in small nodules(15 mm≤diameter≤30 mm)operation of lung hilar region can get the tissue specimens for pathological examination and is relatively safe.Compared with multiple puncture method,the average operation time is shortened and the complication rate reduces,patients can obtain significant clinical benefit by using this puncture technology. 2017 Vol. 24 (9): 82-85 [Abstract] ( 146 ) HTML (49 KB)  PDF  (0 KB)  ( 37 ) 86 Clinical influence factor analysis of the positive rate of transrectal ultrasound-guided prostate biopsy MA Wen-bin;JIANG Hong-hong;GUO Shun-hua Objective To investigate the clinical influence factors of the positive rate of transrectal ultrasound-guided prostate biopsy.Methods Altogether 116 cases of patients who underwent transrectal ultrasound-guided prostate biopsy in our hospital from January 2015 to December 2016 were involved as the object of this experiment.The clinical data of 116 patients were analyzed retrospectively so as to explore the clinical influence factors of the positive rate of transrectal ultrasound-guided prostate biopsy.Results Of the 116 patients,47 patients were identified as prostate cancer and the positive rate was 40.52%,and the positive rate was 57.58%in 2016,which was slightly higher than that in 2015(32.73%). The positive rate of prostate cancers who aged 47-54,55-59,60-69 and 70-79 years old,above 80 years old was 28.57%, 33.33%,39.58%,50.00%and 50.00%;with the increase of age,the positive rate of prostate cancers increased gradually. The positive rate of prostate cancers whose concentration of prostate specific antigen(PSA)ranged from 4-＜10,10-＜20, 20-＜50,50-＜100 to≥100 g/L was 33.33%,31.82%,35.71%,50.00%and 100.00%,respectively.With the increase of PSA concentration,the positive rate of prostate cancers increased gradually.The detection rate of prostate cancers with the prostate volume ranging from＜20,20-＜50,50-＜80 to 80-100 ml was 31.25%,57.58%,38.00%and 23.53%,with significant difference between multiple groups(P＜0.05).According to the multivariate Logistics regression analysis,it was found that the influencing factors of the detection rate of transrectal ultrasound-guided prostate cancers mainly included age, PSA concentration and prostate volume.Conclusion Patients′age,PSA concentration and prostate volume may affect the positive rate of transrectal ultrasound-guided prostate biopsy,therefore,it is recommended to exclude related interference factors when transrectal prostate biopsy is performed. 2017 Vol. 24 (9): 86-88 [Abstract] ( 126 ) HTML (37 KB)  PDF  (0 KB)  ( 35 ) 89 Manifestation and value of multi-slice spiral CT in primary small intestinal lymphoma and small intestine adenocarcinoma TANG Hong-qu;LIU Jin;WU Su;CHEN Xiao-chun Objective To investigate the value of multi-slice spiral CT in the diagnosis of primary intestinal lymphoma and primary intestinal adenocarcinoma.Methods From January 2007 to December 2016,20 patients with primary intestinal adenoearcinoma and 21 patients with primary intestinal lymphoma were selected in our hospital.These 41 disgnosed patients received spiral CT examination.Tumor location and CT features of two tumors were compared.Results In the location of primary intestinal lymphoma,2 cases were in duodenum,4 cases were in jejunum,15 cases were in ileum. In the location of primary intestinal adenocarcinoma,15 cases were in duodenum,3 cases were in jejunum,2 cases were in ileum.It was statistically significant between the two groups(P＜0.05).There was no statistical significance in the CT value of the topical mass between these two primary intestinal tumor patients(P＜0.05).The CT value of arterial phase and venous phase were(46.0±7.6),(67.9±6.5)HU in intestinal lymphoma,which were significantly higher than those of intestinal adenoeareinoma[(103.9±9.1),(103.9±9.1)HU]respectively in contrast enhanced spiral CT,both of the differences were statistically significant(P＜0.05).Conclusion The multi-slice spiral CT features are different between the diagnosis of primary intestinal lymphoma and adenoearcinoma,the diagnostic method is worthy of wide clinical application. 2017 Vol. 24 (9): 89-91 [Abstract] ( 139 ) HTML (36 KB)  PDF  (0 KB)  ( 42 ) 92 Value analysis of BI-RADS ultrasound combined with mammography in the diagnosis of breast carcinoma in situ JIANG Gui-qiong;LIANG Wei-xiang Objective To explore the value of BI-RADS ultrasound combined with mammography in the diagnosis of breast carcinoma in situ.Methods From October 2013 to September 2016,78 female patients with breast cancer in situ confirmed by biopsy in People′s Hospital of Qingxin District of Qingyuan City and the Third Hospital Affiliated to Guangzhou Medical University were proved by pathology were retrospectively analyzed.All patients were examined by BI-RADS ultrasonography and mammography before biopsy,and compared with the pathological biopsy results,the detection rate,misdiagnosis rate and sensitivity in the diagnosis of breast cancer by using BI-RADS (ultrasound examination),mammography alone(X-ray examination)and the combination of both were compared.Results The detection rate of combined examination(94.94%)was higher than that of BI-RADS ultrasonography(87.17%)and mammography (76.92%),with significant difference (P＜0.05).The detection rate of BI-RADS ultrasonography was higher than that of mammography,with significant difference(P＜0.05).The total sensitivity of BI-RADS was 87.17%,which was higher than that of mammography(76.92%),with significant difference(P＜0.05).Among them,the diagnostic sensitivity of the grade 4 in BI-RADS was significantly higher than that of mammography,with significant difference(P＜0.05).But there was no significant difference in the diagnosis sensitivity of grade 5 andⅤdiagnosis between the two groups(P＞0.05).Conclusion BIRADS ultrasound combined with mammography has higher detection rat and higher sensitivity in diagnosis of breast carcinoma in situ,which is worth to promoting. 2017 Vol. 24 (9): 92-94 [Abstract] ( 146 ) HTML (37 KB)  PDF  (0 KB)  ( 32 ) 95 Assessment of the dorsalis pedis artery diseases of diabetic retinopathy patients by ultrasonography ZHANG Na Objective To investigate the clinical value of color Doppler flow imaging (CDFI)in assessing the dorsalis pedis artery (DPA)diseases of diabetic retinopathy (DR)patients and to discuss the relationship between DPA and retinopathy diseases.Methods A total of 78 cases of patients with type 2 diabetes mellitus (T2DM)were selected,who were given the medical treatment in our hospital from May 2015 to August 2016.Based on funduscopic examination,the patients were divided into the no diabetic retinopathy(NDR)group(n=42)and the DR group(n=36),all of which were compared with the normal control(NC)group formed by 33 cases.The diameter(D),intima-media thickness(IMT)and peak systolic velocity(PSV)of the DPA could be measured and calculated using CDFI.Results The D values of the control group,the NDR group and the DR group were(2.21±0.23),(2.03±0.31),(1.62±0.21)mm respectively,the IMT values were (0.24±0.05),(0.32±0.04),(0.41±0.06)mm respectively,the PSV values were (42.89±5.27),(38.91±7.38),(26.56±6.84)cm/s.Compared with the NC group,there were no significant differences in the values of D and PSV of the NDR group(P>0.05),the value of IMT revealed a significant increase(P＜0.05).Compared with the NC group and the NDR group respectively,the values of D and PSV of the DR group were markedly decreased and the IMT was significant increased,the differences were statistically significant(P＜0.05).Conclusion The CDFI can measure the change of structure and hemodynamics of DPA in DR patients,which has certain clinical application value.The change of structure and hemodynamics of DPA is more serious in DR patients. 2017 Vol. 24 (9): 95-97 [Abstract] ( 128 ) HTML (33 KB)  PDF  (0 KB)  ( 33 ) 98 The value of MRI in the diagnosis of occult fracture of knee joint and its classification study HAN Fang;LIU Tian-wen Objective To investigate the clinical value of MRI in the diagnosis of occult fracture of knee joint,and to analyze the MRI classification of occult fracture of knee joint.Methods From January 2013 to December 2016,130 cases of suspected knee occult traumatic fracture patients in our hospital were selected as the research object,all patients underwent spiral CT and MRI examination,surgical diagnosis results was set as the diagnostic reference,the diagnostic sensitivity,specificity and accuracy on occult traumatic fracture of the knee joint were compared between spiral CT and MRI,and the occult traumatic fracture of the knee joint MRI type were analyzed.Results The diagnostic sensitivity,specificity and accuracy of MRI of occult traumatic fracture of the knee joint were 94.23%,96.15%and 94.61%,which was higher than that of spiral CT(83.65%,76.92%,82.31%),with significant difference(P＜0.05).The diagnostic results of MRI diagnosis and surgery results had good agreement,and the spiral CT diagnosis and surgery results consistency only had moderate.In knee occult intraosseous fracture of MRI,there were T1WI low signal and T2WI mixed signal,occult osteochondral fracture MRI showed low T1WI signal and high T2WI signal,recessive cortical fracture MRI showed low signal and high T2WI signal T1WI.Conclusion The diagnostic accuracy of MRI in occult traumatic fracture of the knee joint is high,which can diagnosis knee joint of various types of occult traumatic fracture,can be used as a supplementary means of spiral CT in the diagnosis of occult traumatic fracture of the knee joint,reduce missed diagnosis and misdiagnosis. 2017 Vol. 24 (9): 98-100 [Abstract] ( 160 ) HTML (33 KB)  PDF  (0 KB)  ( 39 ) 101 A randomited study comparing combined Relinqing and Azithromycin for the treatment of cervical chlamydia infection in 128 patients WU Tao;LAI Ting Objective To observe the effect of Relinqing Capsules combined with Azithromycin Capsules treatment of clinical efficacy of cervical Chlamydial infection.Methods 128 cases with cervical Chlamydia infection of hospital of gynecological outpatient from October 2014 to September 2016,and in line with the damp heat and blood stasis type of patients.The patients were randomly divided into observation group(62 cases)and control group(66 cases),the observation group was used Relinqing Capsules combined with Azithromycin Capsules for treatment,the control group was used for Azithromycin Capsules.Symptoms,gynecological examination,Chlamydia detection as the main criteria to determine the efficacy of the treatment of patients with symptoms of traditional Chinese medicine according to the efficacy index. Results Before treatment,there was no significant difference between the two groups in TCM symptom score (P＞0.05). After treatment,the observation group was significantly better than that of control group(P<0.05).The effective rate of observation group was 87.1%,while the control group was 65.2%,with siginificant difference(P<0.05).There were no serious adverse reactions in the two groups.Conclusion In the clinical treatment of cervical chlamydia infection in patients with Relinqing Capsules combined with Azithromycin for treatment,clinical treatment effect is significantly better than using a single Azithromycin treatment effect;and through the application of TCM syndrome score,confirmed that Relinqing Capsules combined with Azithromycin Capsules therapy not only improve symptoms,but also improve the quality of life of patients,treatment play a significant advantage. 2017 Vol. 24 (9): 101-103转106 [Abstract] ( 146 ) HTML (40 KB)  PDF  (0 KB)  ( 48 ) 104 Effect of compound bismuth and magnesium granules-containing quadruple therapy in the treatment of Kirgiz patients with chronic gastritis Ayixianmu·Maimaiti Objective To observe the clinical effect of compound bismuth and magnesium granules-containing quadruple therapy in the treatment of Kirgiz patients with chronic gastritis.Methods 160 cases of Kirgiz patients with chronic gastritis admitted to the People′s Hospital of Kzilsu Kirgiz Autonomous Prefecture from December 2015 to November 2016 were chosen and randomly divided into treatment group and control group,with 80 cases in each group.The patients in the treatment group was given compound Bismuth and Magnesium Granules+Omeprazole+Amoxicillin+Clarithromycin for 14 days;the patients in the control group was given Colloidal Bismuth Pectin+Omeprazole+Amoxicillin+ Clarithromycin for 14 days;and the patients were added the Bismuth preparation for another 14 days in both groups.Hp eradication,gastrointestinal symptoms improvement and adverse drug reaction were compared between 2 groups.Results The rate of Hp eradication in the treatment group was 91.2%,which was slightly higher than that in the control group for 81.2%,and there was no statisticant difference(P＞0.05).The upper abdominal pain symptoms improvement rate was 100.0%in the treatment group,which was higher than that in the control group for 92.5%,with statisticant difference(P< 0.05).The ADR rate in the treatment group was 5.0%,lower than that in the control group for 18.8%,with statisticant difference(P<0.01).Conclusion Compound bismuth and magnesium granules-containing quadruple therapy in the clinical treatment on Kirgiz chronic gastritis has a significant effect,it′s remission of upper abdominal pain symptoms has better effects than colloidal bismuth pectin-containing quadruple therapy,what′s more,it decrease the ADR rate.So,it is worthy of clinical promotion between minority areas. 2017 Vol. 24 (9): 104-106 [Abstract] ( 132 ) HTML (36 KB)  PDF  (0 KB)  ( 10 ) 107 The curative effect of Montelukast in treatment of suffocative bronchitis with respiratory syncytial virus ZHANG Ying-hui;SUN Xiao-li;FENG Guo-xian Objective To observe the therapeutic effects of Montelukast in the treatment of suffocative bronchitis with respiratory syncytial virus(RSV).Methods From October 2014 to October 2016,126 children with suffocative bronchitis with RSV were randomly divided into control(63 cases)and treatment group(63 cases).Infants in control group were treated with conventional therapy,and the experimental group was treated by Montelukast Sodium Chewable Tablets combined with conventional therapy.The efficacy of treatments,pulmonary function tests,recurrence rate,incidence rate of adverse reaction,hospitalization day and total cost were evaluated.Results The total effective rate of experimental group was obviously higher than that of control group(P<0.05).The pulmonary function was obviously improved(P<0.05).The rate of recurrence and incidence rate of adverse reaction in experimental group were significantly lower than control group(P< 0.05).Hospitalization day and total cost of experimental group were reduced compared with control group (P<0.05). Conclusion Montelukast combined withconventional therapy is a high-efficiency and cost-effective therapy in treatment of suffocative bronchitis with RSV. 2017 Vol. 24 (9): 107-109 [Abstract] ( 138 ) HTML (40 KB)  PDF  (0 KB)  ( 34 ) 110 Clinical effect of Probucol combined with Aspirin treating carotid plaques CHEN Ying Objective To investigate the clinical effect of Probucol combined with Aspirin treating carotid plaques. Methods 112 patients with atherosclerosis treated by our hospital from January 2013 to June 2015 were selected as study objects.The patients were divided into two groups according to the random number table method,and there were 56 cases in each group.The control group received Aspirin for oral treatment(two months).On this basis,the observation group was treated with oral administration of Probucol(two months).The level of blood lipid,plaque and adverse events were observed before and after treatment.Results The level of blood lipid,plaque and adverse events were observed before and after treatment.Results After treatment,the total cholesterol [(4.03±0.46)μmol/L],low density lipoprotein [(2.12±0.41)mmol/L],triglyceride[(1.01±0.39)mmol/L],high density lipoprotein[(3.89±0.76)mmol/L],plaque area[(0.61± 0.22)cm2],carotid intima-media thickness[(0.45±0.11)mm]in the observation group were better than the control group [total cholesterol(4.67±0.70)μmol/L,low density lipoprotein(3.05±0.56)mmol/L,triglyceride(2.97±0.58)mmol/L,high density lipoprotein(1.79±0.87)mmol/L,plaque area(0.93±0.30)cm2,carotid artery intima thickness(0.87±0.19)mm)(P＜0.05)].There were no serious adverse events in the two groups,the difference was not significant(P＞0.05).Conclusion Treatment effect of Aspirin combined with Probucol for carotid plaque dissolution is better,and it can effectively regulate blood lipid level,improve plaque,and high safety. 2017 Vol. 24 (9): 110-112 [Abstract] ( 148 ) HTML (37 KB)  PDF  (0 KB)  ( 39 ) 113 Clinical effect of Nimodipine treating cerebral vasospasm caused by spontaneous subarachnoid hemorrhage FANG Ming Objective To investigate the clinical effect of Nimodipine treating cerebral vasospasm caused by spontaneous subarachnoid hemorrhage.Methods Sixty-eight patients with cerebral vasospasm caused by spontaneous subarachnoid hemorrhage treated by our hosopital from January 2016 to January 2017 were selected and randomly divided into control group(n=34)and observation group(n=34).The patients in the control group were treated with conventional therapy.The observation group was treated with Nimodipine on the basis of conventional therapy.The time of cerebrospinal fluid returning to normal,headache duration time,hematoma volume,hospitalization time,middle cerebral artery velocity,inflammatory factor level,GCS score and resuscitation rate were compared between the two groups.Results The time of cerebrospinal fluid returning to normal,headache duration time,hospital stay were shorter than those of control group and hematoma volume of cerebrospinal fluid in observation group was less than that in the control group(P<0.05). The the improvement of middle cerebral artery velocity,and level of inflammatory factor were larger than those of the control group and the rate of rebleeding in observation group was lower than that of control group(P<0.05).Conclusion Nimodipine has a good effect on the treatment of cerebral vasospasm caused by spontaneous subarachnoid hemorrhage, and it is suitable for clinicalpromotion and application. 2017 Vol. 24 (9): 113-115 [Abstract] ( 155 ) HTML (37 KB)  PDF  (0 KB)  ( 31 ) 116 Clinical effect observation of Tamsulosin combined with Pyridostigmine Bromide treating benign prostatic hyperplasia complicated with urinary retention XIA Yu-guo;CHEN Qiu;MEI Xue-feng;ZENG Wen-tong;TIAN Ying;ZHAO Juan;ZENG Zheng-guang;XIONG Guo-bing;YIN Jing Objective To evaluate clinical efficacy of Tamsulosin combined with Pyridostigmine Bromide treating benign prostatic hyperplasia (BPH)complicated with urinary retention.Methods Totally 60 cases of clinically diagnosed BPH with urinary retention from January 2013 to December 2016 were selected and were randomly assigned to group A(n=30) receiving 0.2 mg of Tamsulosin once a day and group B(n=30)receiving 0.2 mg of Tamsulosin once a day plus 30 mg of Pyridostigmine Bromide,3 times a day for 6 weeks,and patients of two groups were indwelled catheter for one week.Before and after the treatment,IPSS,QOL,OABSS,Qmaxand RV were recorded and evaluated.IPSS,QOL,OABSS,Qmaxand RV before and after the treatment and treatment effect between two groups were compared.Results After 6 weeks medication,the assessable cases were 52 cases including 25 cases in group A and 27 cases in group B.Score of IPSS,QOL and Qmax,RV were improved significantly in both groups(P<0.01).Besides,OABSS score was also statistical difference in group A (P<0.05)and group B (P<0.01)before and after treatment.However,IPSS,Qmaxand RV in group B were significantly improved than those in the group A (P<0.05).There was no significant difference in QOL,OABSS score between two groups(P＞0.05).Conclusion Combination therapy with Tamsulosin and Pyridostigmine Bromide is more effective in the treatment of BPH with urinary retention,and it does not significantly increase OAB symptoms,having good clinical application value． 2017 Vol. 24 (9): 116-118 [Abstract] ( 158 ) HTML (37 KB)  PDF  (0 KB)  ( 36 ) 119 Clinical observation on Modified Shentong Zhuyu Decoction combined with Traditional Chinese medicine oriented medication for treating lumbar disc herniation JIE Mu-fu;OU Guan-zhou;ZHU Zui-cheng;XUAN Zhu-neng;QIN Hai-rong Objective To analyze the clinical effects of Modified Shentong Zhuyu Decoction combined with Traditional Chinese medicine oriented medication for treating lumbar disc herniation (LDH).Methods 98 LDH patients admitted into Enping branch of Jiangmen Wuyi Traditional Chinese Medicine Hospital from May 2016 to January 2017 were selected and divided into the treatment group (n=58)and the control group (n=40)according to the different treatment methods.The control group was given conventional treatment,the treatment group was given Modified Shentong Zhuyu Decoction combined with Traditional Chinese medicine oriented medication.The clinical efficacy,clinical symptoms before and after treatment(backache relief situation and lumbar mobility)of the two groups were compared.Results The curative total effective rate of the treatment group was 94.83%,which was significantly higher than 75.00%of the control group,with significant difference(P＜0.05).The JOA score after treatment was(23.98±2.14)points and lumbar flexion degree was(17.03±1.86)mm in the treatment group,which were higher than(20.41±2.33)points,(11.26±2.01)mm in the control group,and the VAS score of the treatment group was(2.43±0.87)points,which was lower than(3.68±1.06)points of the control group,with significant difference(P＜0.05).Conclusion Modified Shentong Zhuyu Decoction combined with Traditional Chinese medicine oriented medication for treating LDH has significant clinical effects,it can effectively relieve clinical symptoms and improve prognostic status,which is worthy of promotion in clinical application. 2017 Vol. 24 (9): 119-121 [Abstract] ( 147 ) HTML (38 KB)  PDF  (0 KB)  ( 29 ) 122 A case of intractable hiccup after stroke treated by Acupuncture WANG Jia-yue WANG Ge-sheng Hiccup,western medicine called"diaphragmatic spasm",when sustained attack＞72 h,the conventional treatment method is ineffective,it is called intractable hiccup.The basic pathogenesis of the disease is that the stomach fails to descend,qi activities in diaphragm is inhibited,and stomach qi rise adversely to disturb the diaphragm.The principle of treatment is relaxing chest and diaphragm,directing qi downward and check hiccups.In clinical treatment of a patient with intractable hiccups after stroke,the author practiced acupuncture on RN 17(dàn zhōng)and RN 12(zhōng wǎn)to regulate qi movement and direct the stomach qi downward,which turned out to be very effective. 2017 Vol. 24 (9): 122-124 [Abstract] ( 149 ) HTML (33 KB)  PDF  (0 KB)  ( 37 ) 125 Analysis of the feasibility of application of acupuncture assisted with massage in the adjuvant treatment of cervical spondylosis of vertebral artery type LIANG Nan;TANG Shu-ping;LIU Xian-tong Objective To explore the clinical effect of acupuncture assisted with massage in the adjuvant treatment of cervical spondylosis of vertebral artery type.Methods Altogether 98 patients with cervical spondylosis of vertebral artery type who were treated in our hospital from January 2014 to December 2015 were selected and divided into the control group and the study group according to the random number table method,49 cases in each group.The control group was treated with massage therapy,the study group was given acupuncture combined with massage treatment.The therapeutic effects and the changes of hemodynamics before and after treatment in the two groups were compared.Results The total effective rate of the study group was 93.87%,which was higher than that in the control group (75.51%), with significant difference(P＜0.05).The indexes of TMFV,PSV,PI,RI after treatment in the two groups were significantly improved compared with before treatment,with significant difference(P＜0.05).The indexes of TMFV and PSV after treatment in the study group was higher than that in the control group,the indexes of PI and RI after treatment in the study group was lower than that in the control group,with significant difference(P＜0.05).Conclusion Combination of application of acupuncture and massage therapy in the adjuvant treatment of patients with cervical spondylosis of vertebral artery type can significantly improve vertebral arterial blood flow status,which can achieve better clinical treatment effect,it is worthy of clinical promotion and application. 2017 Vol. 24 (9): 125-127 [Abstract] ( 130 ) HTML (34 KB)  PDF  (0 KB)  ( 33 ) 128 Effectiveness of combination of detection of serum lipoprotein a，cystatin C and uric acid in the diagnosis of hypertension patients complicated with cerebral infarction LYU Yan-hai;DING You-hui;ZENG Guo-zhi Objective To investigate the effectiveness of combination of detection of serum lipoprotein a[Lp（a）],cystatin C (Cys-C)and uric acid (UA)in the diagnosis of hypertension patients complicated with cerebral infarction.Methods Altogether 64 patients with hypertension complicated with cerebral infarction who were treated in our hospital from April 2014 to October 2015 were selected as observation group;while,72 patients with hypertension who were treated in the hospital at the same period were selected as control group.Lp（a）,Cys-C and UA of the two groups were measured by using latex-enhanced immunoturbidimetric assay and recombinant uric acid oxidation;and the expression levels of Lp（a）,Cys-C and UA were compared between the two groups;the value of combination of detection of Lp（a）,Cys-C and UA in the diagnosis of hypertension patients complicated with cerebral infarction was evaluated.Results Lp（a）, Cys-C and UA of observation group were (379.64±60.28)mg/L,(1.03±0.24)mg/L and (515.60±64.42)μmol/L,respectively,significantly higher than control group[(302.35±47.91)mg/L,(0.86±0.07)mg/L and(427.83±47.65)μmol/L],with statistically significant difference(P<0.05).AUC,sensitivity and specificity of combination of detection of Lp（a）,Cys-C and UA were 0.923,86.72%and 97.24%,higher than those of single Cys-C(0.615,70.32%,84.77%),combination of Cys-C and Lp（a）(0.843,76.84%,88.09%)or UA(0.778,73.21%,87.35%).Conclusion High expression of Lp（a）,Cys-C and UA is seen in patients with hypertension complicated with cerebral infarction.Combination of detection of Lp（a）,Cys-C and UA can effectively improve the accurate rate in diagnosis of hypertension patients complicated with cerebral infarction,which has high clinical significance on the prevention and treatment and improved prognosis in patients with hypertension complicated with cerebral infarction. 2017 Vol. 24 (9): 128-130 [Abstract] ( 144 ) HTML (36 KB)  PDF  (0 KB)  ( 31 ) 131 Distribution and drug sensitivity analysis of bacterial infection in hospitalized patients with mental disorders LU Xi-jian;LU Shen-yan;LU Dan-yu Objective To understand the characteristics of bacterial infection in hospitalized patients with mental disorders,and to provide references for rational use of antibiotics and prevention of nosocomial infection.Methods The results of bacterial culture were analyzed retrospectively of various types of inspection specimens of inpatients with mental disease complicated with bacterial infection of the Fifth People′s Hospital of Nanning City from July 2013 to June 2016.Statistics released by the WHO for drug resistance analysis software version WHONET 5.6,the detection rate of pathogenic bacteria,the composition of pathogens,the distribution and drug resistance of the strains,and the age distribution of the infected people were statistically analyzed.Results Among 2382 clinical specimens,the sputum,throat swabs,blood,urine samples were the mainl types.The conventional sterile specimen accounted for 30.6%.A total of 349 strains of bacteria were isolated,the total positive rate was 14.7%,and the positive rate was the highest in the secretions and urine samples.There were 222 strains(63.6%)from respiratory specimens,and 62 (17.8%)samples were obtained from urinary tract specimens.The pathogens were Klebsiella pneumoniae,Staphylococcus aureus,Mlicrococcus scarlatinae, Escherichia coli,Streptococcus pneumoniae,Pseudomonas aeruginosa in the top 6.Staphylococcus aureus detection rate of MRSA was 20.05%,there was a rising trend,no Vancomycin,Linezolid resistant strains.The resistance rate of Streptococcus pyogenes to Erythromycin was 74.5%,Penicillin resistance was not found.Klebsiella pneumoniae producing ESBLs accounted for 6.3%,Escherichia coli producing ESBLs accounted for 21.2%.Patients with pathogenic bacteria,patients whoagedmorethan59yearsaccounted for 57.9%.Conclusion The hospital psychiatric inpatients complicated with bacterial infection pathogenic bacteria distribution and drug sensitivity results has its own characteristics:the infection of respiratory tract infection and urinary tract in elderly patients with mental disease complicated with bacterial infection more,fewer cases of multi drug resistant bacteria infection,but has gradually rising trend. 2017 Vol. 24 (9): 131-134转140 [Abstract] ( 134 ) HTML (51 KB)  PDF  (0 KB)  ( 46 ) 135 Comparative study of ELISA and GIGA method in the detecting of the HBV serum markers HE Ying-ai;YAO Ye-lin Objective To explore the GIGA method detect hepatitis B virus serum accuracy of the results of the five makers.Methods 357 patients joined the"maternal and infant screening"in the Obstetrics Clinic of our hospital from March 1st,2016 to March 31,2016 were selected,the serum specimen was tested by ELISA method and GIGA method at the same time,the consistency of test results of the two methods were analyzed.Results In 357 cases of serum specimens,286 cases of GIGA method were completely accorded with ELISA method five items,the total consistent rate was 80.11%.But 71 samples were not completely consistent.36 cases of HBsAg positive results of specimens with ELISA method,one patient was not been detected with GIGA method.Conclusion The accuracy of five serum marker of hepatitis B virus GIGA method is slightly lower than ELISA method,but GIGA method is simple,fast and easy observation, and GIGA method of HBsAg detection results are basically identical with ELISA method,it is suitable for rapid screening before emergency surgery and blood donation. 2017 Vol. 24 (9): 135-137转153 [Abstract] ( 149 ) HTML (40 KB)  PDF  (0 KB)  ( 33 ) 138 Study and discuss on the effect of hemolysis on biochemical test results LIU Jin-hua;JIAN Qing-jia;FU Chuan-dong;QIU Hui-qiang;HUANG Jian-lin;ZHAO Shuang-yu Objective To discuss the influence of blood specimen hemolysis on the results of chemical biochemical tests.Methods The blood samples from 100 cases of normal volunteers carried out physical examination in outpatient of our hospital from September to December 2015 for the research object.12 tested indexes of biochemical index blood samples such as alanine aminotransferase(ALT)and aspartate aminotransferase(AST),values of total bilirubin(TBil),direct bilirubin(DBil),total protein(TP),albumin(ALB),creatine kinase(CK),K+,calcium(Ca2+),glucose(GLU),urea nitrogen (BUN),uric acid (UA)were detected before and after hemolysis by the Hitachi Model 7600-010 automatic biochemical analyzer and the levels difference of each indexe was analyzed.Results Levels of AST,ALT,Tbil,Dbil,TP,ALB,CK,K+,Glu, BUN before and after the hemolysis had statistically significant differences(P<0.05);the value of UA,Ca2+had no statistical difference before and after the hemolysis (P>0.05).Conclusion The hemolysis has a great influence on on the clinical and biochemical test,the effect of clinical laboratory tests,in order to reduce or avoid hemolysis phenomenon, clinical staff should be strict in the operating of samples collecting,transport,separate and detecting,and keep higher quality control before test,that can make the results more accurate and reliable. 2017 Vol. 24 (9): 138-140 [Abstract] ( 128 ) HTML (33 KB)  PDF  (0 KB)  ( 39 ) 141 Application study of magnetic hospital concept in quality nursing of outpatient LIU Ai-hua;ZHAO Ya-ting;JI Qiu-lan;CHEN Wen;RAO Wei-hong Objective To study the application effect of magnetic hospital concept in quality nursing of outpatient. Methods 120 nurses from the Fourth Affiliated Hospital of Nanchang University were selected from January 2015 to August 2016.120 nurses were randomly divided into two groups according to the random number method.Each group had 60 nurses.The traditional management model was applied in the control group,and the magnetic hospital management concept was applied in the observation group.The nurses′professional accomplishment was checked and evaluated,theory knowledge,operational skills,clinical ability of nurses were checked,and qualified rate of mastery of the patients′diseases and effective degree of health education for nurses and the patients′satisfaction degree for nursing work were checked,and satisfaction score to the nurses was conducted after one and a half years.Results P rofessional accomplishment score,and score of theory knowledge,operational skills,clinical ability in the observation group was higher than that of the control group respectively,and the difference was statistically significant(P<0.05).The qualified rate of mastery of the patients′diseases in the observation group and satisfaction degree for nursing work were higher than those of the control group (P<0.01).The difference was not statistically significant for effective degree of health education for nurses between two groups (P>0.05).Exception for the balance of work and family,welfare treatment,the rest of the indicators(relations with colleagues,by the praise and recognition,and social or professional exchange opportunities, job control and decision-making,scheduling system,career development opportunities,the overall job satisfaction)in the observation group were better than those of the control group (P<0.05).Conclusion The magnetic hospital concept has good application effect in quality nursing of outpatient,and it can improve the nursing level of nurses,improve the relationship between nurses and patients,and improve the job satisfaction degree of the nurses,and it is worthy of promotion and application in the hospitals. 2017 Vol. 24 (9): 141-143转169 [Abstract] ( 140 ) HTML (44 KB)  PDF  (0 KB)  ( 36 ) 144 Application of"5S"in hospital human resource management thinking and exploration HAO Su-juan;MA Xiu-hua;WANG Ya-juan In order to optimize the human resource,improve the quality of the workforce,"5S"management method is used to People′s Hospital of Daxing District to analyze of present situation of human resource of hospital,and make out corresponding optimal measures,and realize that various personal work by post and examining.Through using the"5S" management method to hackle human resources in our hospital,then the work can be accomplished successful and the talent of everyone can be developed fully,so that we find the best match between people and work. 2017 Vol. 24 (9): 144-146 [Abstract] ( 133 ) HTML (42 KB)  PDF  (0 KB)  ( 38 ) 147 Application effect of hierarchical nursing concept in clinical nursing management ZHAO Yong-hong Objective To observe the application effect of hierarchical nursing concept in clinical nursing management. Methods Hierarchical nursing concept was conducted in clinical nursing management in our hospital,and 80 patients during hospitalization (from January to December 2016)after the concept conducted were selected as the observation group,while another 80 patients during hospitalization (from January to December 2015)before the concept conducted were selected as the control group.The routine clinical nursing management was conducted in the control group in hospital,while hierarchical nursing concept applied in clinical nursing management was conducted in the observation group in hospital.Clinical nursing satisfaction degree in patients in the two groups were observed,and incidence rate of adverse events of nursing safety and medical dispute during hospitalization in the two groups were monitored.Results Clinical nursing satisfaction degree (95.00%)in the observation group was significantly higher than that in the control group(83.75%),and the difference was statistical between two groups(P<0.05).The incidence rate of adverse events of nursing safety in the observation group (1.25%)was significantly lower than that of the control group (8.75%),and the difference was statistical between two groups (P<0.05).Medical dispute did not occur in the observation group,while 1 case(1.25%)occurred in the control group during hospitalization,and there was no statistical difference(P>0.05).Conclusion Application effect of hierarchical nursing concept applied in clinical nursing management is good,and it can effectively improve patients′satisfaction degree,improve the quality of clinical nursing,reduce nursing risk,and it has a higher application value. 2017 Vol. 24 (9): 147-149 [Abstract] ( 123 ) HTML (40 KB)  PDF  (0 KB)  ( 41 ) 150 Details management for nursing workers in operating room is an important link of high quality nursing service JIANG Ying;XIE Chun-hua Objective To explore the value of details management for nursing workers in operating room for improving the core competitiveness of hospitals.Methods March to October 2015,details management was conducted for 11 nursing workers in operating room of the Second Affiliated Hospital of Nanhua University.Before and after details management,checking results of professional knowledge and skills,work quality,satisfaction degree for nursing workers were observed.Results After details management conducted,theory examination score,practice operation assessment result,the overall result were obviously improved compared with before details management conducted,and the difference was statistically significant(P<0.05).Conclusion The implementation of details management in the operation room for nursing workers is conducive to improve the nursing quality and it plays an active role for high quality nursing service in the operation room. 2017 Vol. 24 (9): 150-153 [Abstract] ( 146 ) HTML (46 KB)  PDF  (0 KB)  ( 37 ) 154 Effect of cleaning and disinfection process improvement in promotion of disinfection results of digestive endoscope and infection prevention and control ZHANG Ting Objective To explore the positive effect of the improving endoscopic cleaning and disinfection process on the disinfection result and nosocomial infection prevention and control.Methods Altogether 520 cleaned and disinfected endoscopes and 220 patients diagnosed and treated with digestive endoscopy from October to December 2015 were selected as control group.According to the Technical Operation Specification for Endoscopic Cleaning and Disinfection, comprehensive improvement of the cleaning and disinfection process of endoscopes and accessories was performed from January to May 2016,and then 500 cleaned and disinfected endoscopesand 210 cases of patients diagnosed and treated with digestive endoscopy from June to August 2016 were selected as observation group,and the endoscopic disinfection qualification rate,nosocomial infection qualification rate and patients′satisfaction rate between two groups were compared.Results The disinfection qualification rate of control group were 74.23%and 77.12%,and it was lower than those of observation group (97.60%and 98.60%),with statistically significant difference (P<0.05).The nosocomial infection rate of control group was 1.36%,while observation group had no nosocomial infectioncases;the infection rate was effectively reduced,with statistically significant difference(P<0.05).Patients′satisfaction rate of observation group was 99.05%, and it was significantly higher than of control group(73.18%)(P<0.05).Conclusion Improvement of endoscopic cleaning and disinfection process not only can effectively kill bacteria and increase the disinfection qualification rate,but also can actively prevent nosocomial cross infections and protect patients′health and safety,which is helpful to win the patients′satisfaction,promote harmonious and stable doctor-patient relationship and is worthy of clinical promotion. 2017 Vol. 24 (9): 154-156 [Abstract] ( 150 ) HTML (39 KB)  PDF  (0 KB)  ( 37 ) 157 Epidemiological analysis of hand-foot-mouth disease in Ningde district in Fujian province from 2012 to 2015 LIN Hou-xiong;WANG De-zhi Objective To investigate the epidemiological characteristics of hand-foot-mouth disease in Ningde area, Fujian province from 2012 to 2015.Methods The information system of China CDC was applied.The epidemiological data were used to statistically analyze the monitoring data and pathogenicity results of hand-foot-mouth disease in Ningde area,Fujian province from 2012 to 2015.Real-time fluorescence quantitative polymerase chain reaction was used to test EV71 virus,coxsackievirus A16,and other enteroviruses.Results The incidence of hand-foot-mouth disease in Ningde area of Fujian Province was analyzed.From 2012 to 2015,the number of incidence was in a reducing trend. The number of severe cases and the number of deaths were significantly reduced in 2013.Severe disease rates,mortality rate,and mortality rate of severe diseases were fluctuating.The laboratory diagnosis composition ratio of severe patients was higher than that in the normal patient(P<0.05).The laboratory diagnosis composition ratio of deceased patients was higher than that in the normal patients and severe patients(P<0.05).The composition ratio of EV71 virus in severe patients and deceased patients was higher than that of coxsackievirus A16 and other enteroviruses (P<0.05).The number of patients in rural area was higher,and the incidence rate of severe diseases,mortality rate and mortality of severe diseases were higher in rural areas than in urban areas(P<0.05).Conclusion The number of hand-foot-mouth disease in Ningde area of Fujian province is in a decreasing trend from 2012 to 2015,and incidence rate of severe diseases and mortality rate,although fluctuating,still remain in a low level. 2017 Vol. 24 (9): 157-159 [Abstract] ( 120 ) HTML (39 KB)  PDF  (0 KB)  ( 35 ) 160 Effect of application of flipped classroom teaching mode in the teaching of nursing specialty in colleges and universities DONG Ming;XU Wei-wei;WEI Jia;SUN Li-xin Objective To explore the best teaching methods for nursing specialty.Methods 85 cases nursing students of our school from March to July 2016 were divided into observation group and control group,the control group was taught by using traditional LBL (lecture-based learning)teaching method;while,the observation group was educated by using flipped classroom teaching mode.The teaching effectiveness of two groups were compared from 3 aspects,including students′learning experience,evaluation of teachers′teaching ability and the final grade in Internal Medicine Nursing. Results According to the student survey results,the students′learning experience,evaluation of teachers′teaching ability and the final grade in observation group were better than those of control group,with statistically significant differences between two groups(P<0.05).Conclusion The flipped classroom teaching mode integrates the learning content inside and outside the classroom together to improve the teaching effectiveness. 2017 Vol. 24 (9): 160-162 [Abstract] ( 159 ) HTML (44 KB)  PDF  (0 KB)  ( 38 ) 163 Effect of application of clinical case analysis in the cultivation of critical thinking ability for less-experienced midwives HE Qing-feng;YUAN Yue-hua;ZHANG Chun-yan Objective To explore the effect of clinical case analysis in the cultivation of critical thinking ability for lessexperienced midwives,and to provide a reference for the future training model so as to promote the individual management of duration of labor.Methods Altogether 15 newly-recruited midwives(newly-recruited midwife group)who worked in delivery room in our hospital from June 2012 to June 2016 and 34 internship midwives(intern midwife group)were involved as the observation samples.Each clinical case related to the two groups during their work was analyzed and commented, respectively.CTDI-CV(Chinese version of the Critical Thinking Disposition Inventory)was used to perform comparative analysis of two groups after newly-recruited midwife group gained 6 months work experience.Results Before the trial of clinical case analysis,the CTDI-CV score of intern midwife group was(247.11±31.86)points,and the newly-recruited midwife group was(250.41±28.24)points,without significant difference(P>0.05);after 6 months trial of clinical case analysis, the CTDI-CV score of intern midwife group was(308.94±36.33)points,the newly-recruited midwife group was(324.34± 34.18)points;the CTDI-CV score of both groups were highly improved in comparison with that before training,with significant difference(P<0.05);the newly-recruited midwife group was achieved significantly better scores in truth discovery,analytical skills,systematic ability,thinking self-confidence and curiosity were improved than those of intern midwife group after training;and with the prolongation of training time,the difference between the two groups was more obvious, with statistical significance(P<0.05).Conclusion The clinical case analysis can significantly improve the critical thinking ability for less-experienced midwives,which is an ideal model of in-service training for midwives.And with the prolongation of training time,stronger critical thinking ability is gained by less-experienced midwives. 2017 Vol. 24 (9): 163-165 [Abstract] ( 144 ) HTML (38 KB)  PDF  (0 KB)  ( 35 ) 166 Intervention effect of health education path on platelet distribution width in patients with type 2 diabetes CHEN Xiao-hong;YANG Zhuo-qun;MAI Pei-shan Objective To explore the effect of health education path on platelet distribution width in patients with type 2 diabetes.Methods 100 patients with the type 2 diabetes in our hospital from March 2013 to May 2015 were randomly divided into the experiment group and the control group,with 50 cases in each group.Patients in the control group were treated with routine medicine and general health education,while patients in the experimental group were treated with conventional medicine and one by one diabetes health education pathway.1,3,6 months after health education,the levels of diabetic knowledge,FBG and platelet distribution width and 3,6 months after health education,the level of glycated hemoglobin of patients between two groups were compared.Results 1,3,6 months after health education,the levels of diabetic knowledge of patient in the observation group was higher than that in the control group;3,6 months after health education,the levels of FBG,platelet distribution width and glycated hemoglobin of patients in the observation group were lower than that in the control group.ALL the difference were statistically significant(P<0.05).Conclusion The implementation of health education pathway in the type 2 diabetes can reduce the platelet distribution width,thereby reducing the incidence of cardiovascular and cerebrovascular complications,worthy of clinical application and popularization. 2017 Vol. 24 (9): 166-169 [Abstract] ( 147 ) HTML (44 KB)  PDF  (0 KB)  ( 38 ) 170 Application effect of high-quality nursing concept in patients received radical resection of lung cancer SONG Li-xia;YI Yun-lan;WANG Xiao-yan;JIANG Hong-yi;ZHONG Lan-feng Objective To explore the application effect of high quality nursing concept in patients received radical resection of lung cancer.Methods 90 patients received radical resection of lung cancer from September 2014 to June 2016 in our hospital were selected and randomly divided into the control group(n=45)and the observation group(n=45). Patients in the control group were treated with routine nursing mode,while patients in the observation group were treated with high-quality care.The incidence of postoperative complications and nursing satisfaction of patients between two groups were compared.Results The incidence of postoperative complications in the observation group(8.88%)was lower than that in the control group(26.66%),and the difference was statistically significant(χ2=4.8649,P=0.0274).The nursing satisfaction of patients in the observation group(95.55%)was higher than that in the control group(80.00%),and the difference was statistically significant(χ2=5.0748,P=0.0242).Conclusion The patients with radical resection for lung cancer can effectively reduce the incidence of postoperative complications and improve nursing satisfaction.Nursing work is fully affirmed and has clinical value. 2017 Vol. 24 (9): 170-172 [Abstract] ( 122 ) HTML (35 KB)  PDF  (0 KB)  ( 33 ) 173 Application of FTS-CNP nursing model in perioperative period of patients with benign thyroid tumor KE Dan-chun;YE Xiao-hui;HUANG Su-hua;XIAO Yong;YANG Zhong-xin Objective To explore the application of FTS-CNP nursing model in perioperative period of patients with benign thyroid tumor.Methods 160 cases of patients with benign thyroid tumor in our hospital from August 2014 to January 2016 were selected and divided into the observation group and the control group,with 80 cases in each group according to the envelope method.Patients in the observation group were treated with FTS-CNP nursing mode while patients in the control group were treated with traditional nursing methods.The levels of perioperative stress indexes,postoperative recovery indicators,health knowledge awareness,patient satisfaction with nurses and the level of pain were compared between the two groups.Results 1 day after operation,the levels of MAP,HR and IR of patients in the control group were higher than those before operation and than those in the observation group;the time of first eating,firse activity out of bed and hospitalization in the observation group were shorter than that in the control group;the incidence of complications was lower than that in the control group;the levels of health knowledge awareness,patient satisfaction with nurses were higher than those in the control group,the level of pain was lower than that in the control group,and the differences were all statistically significant(P<0.05).Conclusion Perioperative nursing mode by FTS-CNP for patients with enign thyroid tumor could reduce the painness of patients,reduce the incidence of complications,reduce the average hospitalization time,and improve patient satisfaction with nursing work. 2017 Vol. 24 (9): 173-176 [Abstract] ( 154 ) HTML (48 KB)  PDF  (0 KB)  ( 28 ) 177 Application of primary prevention education in prevention of stroke in patients with cardiovascular disease LI Wen-jing;ZHUANG Yi-hao;TANG Ti;CHEN Hai-bo Objective To explore the application of primary prevention education in prevention of stroke in patients with cardiovascular disease.Methods 200 cases patients with cardiovascular disease in Meilin Village Community Health Center from September 2013 to May 2014 were selected as the subjects,the risk of stroke,the issuance of health education manual,the implementation of health education intervention and a series of interventions were evaluated to prevent the occurrence of stroke.Results There were significant difference in the distribution of risk of stroke before and after intervention(P<0.05).The awareness rate of prevention knowledge was significantly improved (P<0.05).Conclusion Stroke screening and health education intervention for patients with cardiovascular disease can strengthen the knowledge of stroke prevention and achieve the purpose of preventing stroke. 2017 Vol. 24 (9): 177-179 [Abstract] ( 148 ) HTML (37 KB)  PDF  (0 KB)  ( 36 ) 180 The effect of comprehensive nursing intervention on immune function of patients with advanced liver cancer WANG Bo-jun;LIU Zheng-rong Objective To explore the effect of comprehensive nursing intervention on the immune function of patients with advanced liver cancer.Methods 96 patients with advanced liver cancer in our hospital from March 2014 to March 2016 were randomly divided into observation group and control group according to the random principle,48 cases in each group.The control group was treated routine nursing method,the observation group was treated nursing intervention, the immune function and quality of life were compared between the two groups,and the nursing satisfaction of the two groups were recorded.Results Compared with before intervention,the two groups after the intervention of peripheral blood lymphocyte subsets and factor in type Th1 cells and the levels were increased,there were significant differences (P<0.05);the observation group after the intervention of peripheral blood lymphocyte subsets was significantly higher than that of control group,the serum levels of Th1 type cytokine content was significantly higher than that of control group,with significant difference(P<0.05);compared with the control group,the role of body dimensions QLQ-30 score and total score in observation group were significantly improved,the differences were significant(P<0.05).Conclusion the comprehensive nursing intervention for patients with advanced liver cancer can effectively improve the immune function of patients,it is worthy of clinical application. 2017 Vol. 24 (9): 180-182转185 [Abstract] ( 134 ) HTML (43 KB)  PDF  (0 KB)  ( 37 ) 183 Influence of early nursing intervention on perinatal complications of pregnant women with gestational diabetes mellitus HU Yan Objective To observe and study the influence of early nursing intervention on perinatal complications in pregnant women with gestational diabetes mellitus.Methods 100 cases of gestational diabetes treated in our hospital from June 2015 to Angust 2016 were selected as the research object,they were divided into control group and study group by means of random classification,50 cases in each group,the control group was given routine nursing intervention,the study group was given early nursing intervenion on the base of control group,the nursing outcomes of two groups were compared.Results The rate of complications of hypertension during pregnancy,polyhydramnios,cesarean section,premature birth,postpartum hemorrhage and childbed disease in study group were significantly lower than those in control group,the differences were significant(P<0.05),the maternal neonatal complications in study group was significantly better than that in control group,the difference was significant(P<0.05).Conclusion Early nursing care can effectively reduce the incidence of perinatal complications of gestational diabetes mellitus,improve maternal postpartum physical condition,and has a significant clinical effect,which is worthy of promotion and application. 2017 Vol. 24 (9): 183-185 [Abstract] ( 155 ) HTML (38 KB)  PDF  (0 KB)  ( 37 ) 188 Application of evidence-based nursing in rehabilitation of schizophrenic patients CHEN Ze-qun;JIANG Jian-mao;WEI Chang-shu;CAO Yun-zhen Objective To investigate the effect of evidence-based nursing in the rehabilitation of patients with schizophrenia.Methods 112 cases of schizophrenia patients from December 2014 to December 2015 in Civil Affairs Bureau of Guangzhou city mental hospital,the patients were randomly divided into control group and observation group, 56 cases in each group,the control group was given routine nursing,the observation group was received evidence-based nursing,with positive and negative symptom scale (PANSS)and social function the defect scale (SDSS-1)score were used.Results The patients of two groups before nursing,PANSS positive symptoms score,PANSS score of negative symptoms and general psychopathology score had no significant differences(P>0.05);the patients of observation group with PANSS positive symptom score after nursing was(20.4±1.7)points,and PANSS negative symptom score was(10.2± 1.5)points,significantly better than those of control group of(22.7±3.4),(13.2±2.5)points(P<0.05).The nursing of two groups before the occupation ability,social ability,family function and life ability score had no significant difference(P> 0.05);patients in the observation group after the nursing occupation ability was (0.2±0.1),social skills was (0.2±0.1), family function was(0.8±0.1),ability of daily life was(0.8±0.2)points,and the scores were significantly better than those ofcontrol group (P<0.05).Conclusion The application of evidence-based nursing in the rehabilitation nursing of patients with schizophrenia is significant,it is worthy of clinical promotion. 2017 Vol. 24 (9): 188-188转191 [Abstract] ( 157 ) HTML (37 KB)  PDF  (0 KB)  ( 32 ) 189 Effect of psychological nursing care on stress response of patients with gastrointestinal bleeding under endoscope DENG Zhi-he;ZHANG Er-hua Objective To investigate the effect of psychological nursing care on stress response of patients with gastrointestinal bleeding under endoscope.Methods 360 cases of patients with gastrointestinal bleeding treated in our hospital from August 2015 to August 2016 were selected as the research objects and were randomly divided into observation group and control group,180 cases in each group.Patients in the control group were given routine nursing,while patients in the observation group were given psychological nursing care based on the treatment in the control group.The psychology and the response to physiological stress response of patients were compared in two groups.Results There was no significant difference in heart rate and mean arterial pressure between the two groups before treatment(P＞0.05).Compared the mean arterial pressure and heart rate in and after the treatment in the observation group with those in the control group,the difference was significant(P<0.01).There were no significant differences in mental state scores of the patients in two groups before treatment(P>0.05).The scores of self rating depression scale (SDS)and self rating anxiety scale (SAS)in the observation group were lower than those of the control group and the differences were statistically significant(P<0.01).Conclusion Application of psychological nursing in the treatment of gastrointestinal bleeding under endoscope can reduce the degree of psychological and physiological stress response,improve the therapeutic effect.This method has a positive effect on promoting the rehabilitation of the disease,which is worth promoting. 2017 Vol. 24 (9): 189-191 [Abstract] ( 141 ) HTML (36 KB)  PDF  (0 KB)  ( 31 ) 192 Application effect of comprehensive nursing in patients with chronic obstructive pulmonary disease complicated withⅡ-respiratory failure LI Xiu-ying;SHI Zhen-dong;LIU Zhe Objective To explore the application effect of comprehensive nursing in patients with chronic obstructive pulmonary disease(COPD)complicated withⅡ-respiratory failure(Ⅱ-RF).Methods 102 patients with COPD complicated withⅡ-RF from January 2013 to January 2016 in our hospital were divided into control group and observation group according to different nursing methods,51 cases in each group.Both groups patients were treated infection control,expectorant,antispasmodic,correct acid-base balance,nutrition,using BiPAP ventilator and other conventional treatment,the control group was given routine nursing,the observation group was given comprehensive nursing.Nursing satisfaction score,average hospitalization time and half year relapse rate were compared between the two groups.Results The nursing satisfaction score in observation group was(98.2±1.5)points,that was(82.6±3.9)points in control group,and the difference was statistical significance(P<0.05).The average hospitalization time in observation group was(28.56±2.92)days, that was(36.39±6.89)days in control group,and the difference was statistical significance(P<0.05).The 6 months relapse rate in observation group was 13.7%,was significantly lower than that in control group of 27.5%,and the difference was statistical significance(P<0.05).Conclusion Comprehensive nursing can improve the nursing satisfaction of the COPD complicated withⅡ-RF patients satisfaction degree of nursing,which promotes the recovery of disease and reduces the recurrence rate significantly. 2017 Vol. 24 (9): 192-194转197 [Abstract] ( 149 ) HTML (42 KB)  PDF  (0 KB)  ( 29 ) 195 Study of pediatric critical disease nursing scoring as intervention guidance on pediatric nursing ZHU Yan Objective To explore the pediatric critical disease nursing scoring as intervention guidance on pediatric nursing.Methods A total of 90 children in critical conditions treated in our hospital from May 2014 to May 2016 were selected as the observation objects.Using the digital table,they were evenly divided into observation group and control group in random,45 cases in each group.In the control group,regular nursing for critical conditions was used,while in the observation group,on the basis of the regular nursing,critical disease nursing scoring as intervention was provided. After 2-week care,the occurrence of complications and family care satisfaction were compared between the two groups. Results After nursing,the number of cases with the critical condition nursing score less than 70 points,70 to 80 points and over 80 points was 20,17 and 8 cases respectively in the observation group.The incidence of complications in patients whose scores less than 70 points was 55.00%after nursing,which much higher than those whose scores between 70 to 80 points(29.41%)and over 80 points(12.50%).In the observation group,family care satisfaction was 97.78%,much higher than that in the control group accounting for 82.22% (P<0.05).Conclusion In pediatric nursing under critical conditions,application of critical disease nursing scoring as intervention can get known the disease conditions in children patients and provide effective basis for nursing in a remarkable nursing effect. 2017 Vol. 24 (9): 195-197 [Abstract] ( 116 ) HTML (34 KB)  PDF  (0 KB)  ( 38 )

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