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| Effect of compound bismuth and magnesium granules-containing quadruple therapy in the treatment of Kirgiz patients with chronic gastritis |
| Ayixianmu·Maimaiti |
| Department of Gastroenterology,People′s Hospital of Kzilsu Kirgiz Autonomous Prefecture,Xinjiang Uygur Autonomous Region,Artux 845350,China |
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Abstract Objective To observe the clinical effect of compound bismuth and magnesium granules-containing quadruple therapy in the treatment of Kirgiz patients with chronic gastritis.Methods 160 cases of Kirgiz patients with chronic gastritis admitted to the People′s Hospital of Kzilsu Kirgiz Autonomous Prefecture from December 2015 to November 2016 were chosen and randomly divided into treatment group and control group,with 80 cases in each group.The patients in the treatment group was given compound Bismuth and Magnesium Granules+Omeprazole+Amoxicillin+Clarithromycin for 14 days;the patients in the control group was given Colloidal Bismuth Pectin+Omeprazole+Amoxicillin+ Clarithromycin for 14 days;and the patients were added the Bismuth preparation for another 14 days in both groups.Hp eradication,gastrointestinal symptoms improvement and adverse drug reaction were compared between 2 groups.Results The rate of Hp eradication in the treatment group was 91.2%,which was slightly higher than that in the control group for 81.2%,and there was no statisticant difference(P＞0.05).The upper abdominal pain symptoms improvement rate was 100.0%in the treatment group,which was higher than that in the control group for 92.5%,with statisticant difference(P< 0.05).The ADR rate in the treatment group was 5.0%,lower than that in the control group for 18.8%,with statisticant difference(P<0.01).Conclusion Compound bismuth and magnesium granules-containing quadruple therapy in the clinical treatment on Kirgiz chronic gastritis has a significant effect,it′s remission of upper abdominal pain symptoms has better effects than colloidal bismuth pectin-containing quadruple therapy,what′s more,it decrease the ADR rate.So,it is worthy of clinical promotion between minority areas.
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| [1] |
刘文忠.＂幽门螺杆菌胃炎京都全球共识＂解读[J].胃肠病学，2015，20（8）：449-455.
|
| [2] |
米日古丽·艾力.克州维、汉、柯幽门螺旋杆菌感染状况调查分析[J].中国当代医药，2013，20（10）：162-163.
|
| [3] |
刘文忠，谢勇，成虹，等.第四次全国幽门螺杆菌感染处理共识报告[J].现代消化及介入诊断，2012，17（6）：359-363. [4]雪来提·艾孜木.胃铋镁四联疗法根除维吾尔族患者幽门螺杆菌的效果[J].中国医药导报，2015，12（34）：130-133.
|
| [5] |
Sgouras DN，Trang TT，Yamaoka Y.Pathogenesis of Helicobacter pylori Infection[J].Helicobacter，2015，20（Suppl 1）：8-16.
|
| [6] |
Sugano K，Tack J，Kuipers EJ，et al.Kyoto global consensus report on Helicobacter pylori gastritis[J].Gut，2015，64（9）：1353-1367.
|
| [7] |
刘爱茹，杜奕奇.我国幽门螺杆菌感染现状和治疗策略的改变[J].世界华人消化杂志，2016，24（32）：4396-4403.
|
| [8] |
张万岱，胡伏莲，萧树东，等.中国自然人群幽门螺杆菌感染的流行病学调查[J].现代消化及介入诊疗，2010，15（5）：265-270.
|
| [9] |
Li Q，Wang NN，Hu FL，et al.Study of compound bismuth and magnesium granules on clearance of helicobacter pylori infection in KM mice[J].Int J Clin Exp Med，2016，9（7）：12888-12895.
|
| [10] |
牟方宏，胡伏莲，魏红，等.胃铋镁颗粒对阿司匹林所致大鼠胃黏膜损伤的预防作用机制[J].中华医学杂志，2016，96（6）：464-467.
|
| [11] |
王佳林，宋洁，张慧，等.胃铋镁四联疗法治疗幽门螺杆菌阳性胃溃疡的临床效果研究[J].中国当代医药，2015，22（30）：92-94.
|
| [12] |
乔巍，邸军，汪小莞，等.胃铋镁中药组分对胃癌细胞周期的调节和裸鼠体内肿瘤抑制的实验研究[J].中国生化药物杂志，2016，36（6）：25-29.
|
| [13] |
乔巍，邸军，汪小莞，等.胃铋镁对胃癌细胞凋亡的诱导作用及机制研究[J].中国生化药物杂志，2016，36（7）：15-18.
|
| [14] |
张明，邓毅.甘草及其有效成分的药效学研究进展[J].西部中医药，2015，8（4）：156-159.
|
| [15] |
李聚仓，王德才.芦荟药理作用研究进展[J].泰山医学院学报，2011，32（2）：158-160.
|
| [16] |
付起凤，张艳丽，许树军，等.小茴香化学成分及药理作用的研究进展[J].中医药信息，2008，25（5）：24-26.
|
| [17] |
王睿，费洪新，李晓明，等.石菖蒲的化学成分及药理作用研究进展[J].中华中医药学刊，2013，31（7）：1606-1610.
|
|
|
|
