|
|
|
| Clinical effect observation of Tamsulosin combined with Pyridostigmine Bromide treating benign prostatic hyperplasia complicated with urinary retention |
| XIA Yu-guo1 CHEN Qiu1▲ MEI Xue-feng1 ZENG Wen-tong1 TIAN Ying1 ZHAO Juan1 ZENG Zheng-guang2 XIONG Guo-bing3YIN Jing4 |
1.Department of Urology,School of Clinical Medicine (Affiliated Hospital)of Chengdu University of Traditional Chinese Medicine,Sichuan Province,Chengdu 610072,China;
2.Department of Andrology,Chengdu Research Institute of Urology in Sichuan Province,Chengdu 610072,China;
3.Department of Urology,Sichuan Provincial People′s Hospital,Chengdu 610041,China;
4.Department of Andrology,Sichuan Integrative Traditional Chinese and Western Medicine Hospital, Chengdu 610041,China |
|
|
|
|
Abstract Objective To evaluate clinical efficacy of Tamsulosin combined with Pyridostigmine Bromide treating benign prostatic hyperplasia (BPH)complicated with urinary retention.Methods Totally 60 cases of clinically diagnosed BPH with urinary retention from January 2013 to December 2016 were selected and were randomly assigned to group A(n=30) receiving 0.2 mg of Tamsulosin once a day and group B(n=30)receiving 0.2 mg of Tamsulosin once a day plus 30 mg of Pyridostigmine Bromide,3 times a day for 6 weeks,and patients of two groups were indwelled catheter for one week.Before and after the treatment,IPSS,QOL,OABSS,Qmaxand RV were recorded and evaluated.IPSS,QOL,OABSS,Qmaxand RV before and after the treatment and treatment effect between two groups were compared.Results After 6 weeks medication,the assessable cases were 52 cases including 25 cases in group A and 27 cases in group B.Score of IPSS,QOL and Qmax,RV were improved significantly in both groups(P<0.01).Besides,OABSS score was also statistical difference in group A (P<0.05)and group B (P<0.01)before and after treatment.However,IPSS,Qmaxand RV in group B were significantly improved than those in the group A (P<0.05).There was no significant difference in QOL,OABSS score between two groups(P＞0.05).Conclusion Combination therapy with Tamsulosin and Pyridostigmine Bromide is more effective in the treatment of BPH with urinary retention,and it does not significantly increase OAB symptoms,having good clinical application value．
|
|
|
|
|
|
| [1] |
那彦群，叶章群，孙颖浩，等.中国泌尿外科疾病诊断治疗指南[M].北京：人民卫生出版社，2014：245.
|
| [2] |
Nazir J，Heemstra L，van Engen A，et al.Cost-effectiveness of a fixed-dose combination of solifenacin and oral controlled adsorption system formulation of tamsulosin in men with lower urinary tract symptoms associated with benign prostatic hyperplasia[J].BMC Urol，2015，15（1）：41.
|
| [3] |
许克新，王焕瑞.良性前列腺增生/良性前列腺梗阻手术治疗指征的思考——CUA指南对手术治疗指征的推荐恰当吗?[J].现代泌尿外科杂志，2016，（2）：84-86.
|
| [4] |
Mobley D1，Feibus A，Baum N.Benign prostatic hyperplasia and urinary symptoms：evaluation and treatment[J].Postgrad Med，2015，127（3）：301-307.
|
| [5] |
吴小云，向紫兵，徐辉.短期大剂量爱普列特联合坦络新治疗前列腺增生症并尿潴留的效果观察[J].中国当代医药，2015，22（2）：115-117，120.
|
| [6] |
罗凌坚，陈薇，傅恩君.坦索罗辛治疗前列腺增生的效果和安全性分析[J].中国当代医药，2016，23（33）：59-61.
|
| [7] |
安琪，刘德忠，陈一然，等.盐酸坦索罗辛治疗前列腺增生症的系统回顾及更新荟萃分析（英文）[J].中国性科学，2015，24（10）：35-46.
|
| [8] |
李青，李明川，姜永光，等.大剂量坦索罗辛治疗良性前列腺增生引起下尿路症状的前瞻性研究[J].中华泌尿外科杂志，2012，33（2）：117-119.
|
| [9] |
吴宗倍，戴永雄.良性前列腺增生患者合并尿潴留的临床治疗效果分析[J].中外医学研究，2016，14（18）：25-26.
|
| [10] |
Kang M，Kim M，Choo MS，et al.Association of high bladder neck elevation with urodynamic bladder outlet obstruction in patients with lower urinary tract symptoms and benign prostatic hyperplasia[J].Urology，2014，84（6）：1461-1466.
|
| [11] |
张豪杰，盛璐，陈然，等.经尿道钬激光前列腺剜除术与经尿道等离子前列腺剜除术治疗前列腺增生的疗效比较[J].中国临床医学，2016，23（5）：636-639.
|
| [12] |
宋春生，赵家有，郭军，等.癃闭舒胶囊联合甲磺酸多沙唑嗪片治疗良性前列腺增生症的临床研究[J].中国中西医结合杂志，2016，36（12）：1465-1469.
|
| [13] |
Gounden S，Lee B，Mellick R，et al.Ocular myasthenia gravis in a person with tetraplegia presenting challenges in diagnosis and management[J].Spinal Cord Ser Cases，2016，2：15037.
|
| [14] |
韩雨，曹延炜，于芹超，等.不同α受体阻滞剂联合M受体阻滞剂治疗伴有下尿路症状的前列腺增生的疗效比较[J].现代泌尿外科杂志，2014，19（5）：311-314.
|
| [15] |
高建华，高秀蓉，许小红.溴吡斯的明剂型研究进展[J].中国药房，2016，27（4）：545-547.
|
|
|
|
