血清脂蛋白a、胱抑素C和尿酸的联合检测在高血压并发脑梗死患者中的诊断价值

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Abstract Objective To investigate the effectiveness of combination of detection of serum lipoprotein a[Lp（a）],cystatin C (Cys-C)and uric acid (UA)in the diagnosis of hypertension patients complicated with cerebral infarction.Methods Altogether 64 patients with hypertension complicated with cerebral infarction who were treated in our hospital from April 2014 to October 2015 were selected as observation group;while,72 patients with hypertension who were treated in the hospital at the same period were selected as control group.Lp（a）,Cys-C and UA of the two groups were measured by using latex-enhanced immunoturbidimetric assay and recombinant uric acid oxidation;and the expression levels of Lp（a）,Cys-C and UA were compared between the two groups;the value of combination of detection of Lp（a）,Cys-C and UA in the diagnosis of hypertension patients complicated with cerebral infarction was evaluated.Results Lp（a）, Cys-C and UA of observation group were (379.64±60.28)mg/L,(1.03±0.24)mg/L and (515.60±64.42)μmol/L,respectively,significantly higher than control group[(302.35±47.91)mg/L,(0.86±0.07)mg/L and(427.83±47.65)μmol/L],with statistically significant difference(P<0.05).AUC,sensitivity and specificity of combination of detection of Lp（a）,Cys-C and UA were 0.923,86.72%and 97.24%,higher than those of single Cys-C(0.615,70.32%,84.77%),combination of Cys-C and Lp（a）(0.843,76.84%,88.09%)or UA(0.778,73.21%,87.35%).Conclusion High expression of Lp（a）,Cys-C and UA is seen in patients with hypertension complicated with cerebral infarction.Combination of detection of Lp（a）,Cys-C and UA can effectively improve the accurate rate in diagnosis of hypertension patients complicated with cerebral infarction,which has high clinical significance on the prevention and treatment and improved prognosis in patients with hypertension complicated with cerebral infarction.

Key words： Hypertension Cerebral infarction Lp（a） Cys-C UA

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	LYU Yan-hai
	DING You-hui
	ZENG Guo-zhi

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LYU Yan-hai,DING You-hui,ZENG Guo-zhi. Effectiveness of combination of detection of serum lipoprotein a，cystatin C and uric acid in the diagnosis of hypertension patients complicated with cerebral infarction[J]. 中国当代医药, 2017, 24(9): 128-130.

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http://dangdaiyiyao.com/EN/ OR http://dangdaiyiyao.com/EN/Y2017/V24/I9/128

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